Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionscaffold protein binding

NLGN3 PLCG2 RYR2 CHUK

1.44e-0493574GO:0097110
MousePhenoskin inflammation

RAG1 SH3BP2 FADS2 PLCG2 CHUK

1.87e-05105445MP:0004947
DomainGrip

RGPD8 RGPD5

4.77e-0411562SM00755
DomainGRIP

RGPD8 RGPD5

4.77e-0411562PF01465
DomainRan_BP1

RGPD8 RGPD5

5.72e-0412562PF00638
DomainGRIP_dom

RGPD8 RGPD5

5.72e-0412562IPR000237
DomainGRIP

RGPD8 RGPD5

5.72e-0412562PS50913
DomainRANBD1

RGPD8 RGPD5

5.72e-0412562PS50196
DomainRanBD

RGPD8 RGPD5

6.74e-0413562SM00160
DomainRan_bind_dom

RGPD8 RGPD5

6.74e-0413562IPR000156
DomainSema

SEMA6D PLXND1

3.88e-0331562SM00630
DomainSemap_dom

SEMA6D PLXND1

3.88e-0331562IPR001627
DomainSema

SEMA6D PLXND1

3.88e-0331562PF01403
DomainSEMA

SEMA6D PLXND1

3.88e-0331562PS51004
DomainPSI

SEMA6D PLXND1

4.13e-0332562PF01437
DomainPlexin_repeat

SEMA6D PLXND1

4.13e-0332562IPR002165
DomainPSI

SEMA6D PLXND1

7.71e-0344562IPR016201
DomainPSI

SEMA6D PLXND1

8.40e-0346562SM00423
DomainPH_dom-like

RGPD8 SH3BP2 PLCG2 FAM43A RGPD5

8.87e-03426565IPR011993
PathwayWP_2Q13_COPY_NUMBER_VARIATION_SYNDROME

POLR1A RGPD8 PLCG2 IL1R1

3.24e-0563414M45526
Pubmed

Airway uric acid is a sensor of inhaled protease allergens and initiates type 2 immune responses in respiratory mucosa.

RAG1 IL1R1 F2RL1

5.24e-071058324663677
Pubmed

Role of murine intestinal interleukin-1 receptor 1-expressing lymphoid tissue inducer-like cells in Salmonella infection.

RAG1 IL1R1

2.73e-06258223750260
Pubmed

Liver-directed lentiviral gene therapy corrects hemophilia A mice and achieves normal-range factor VIII activity in non-human primates.

RAG1 F8

2.73e-06258235508619
Pubmed

IKKα is required for the homeostasis of regulatory T cells and for the expansion of both regulatory and effector CD4 T cells.

RAG1 CHUK

2.73e-06258225376833
Pubmed

Hepatic energy state is regulated by glucagon receptor signaling in mice.

GCGR PCK1

2.73e-06258219662685
Pubmed

Autoimmunity and inflammation due to a gain-of-function mutation in phospholipase C gamma 2 that specifically increases external Ca2+ entry.

RAG1 PLCG2

2.73e-06258215845450
Pubmed

Protein Palmitoylation by ZDHHC13 Protects Skin against Microbial-Driven Dermatitis.

RAG1 IL1R1 CHUK

4.18e-061958328017833
Pubmed

Autism-linked NLGN3 is a key regulator of gonadotropin-releasing hormone deficiency.

NLGN3 PLXND1

8.19e-06358236810932
Pubmed

Acylglycerol Kinase Maintains Metabolic State and Immune Responses of CD8+ T Cells.

RAG1 AGK

8.19e-06358231204281
Pubmed

SH3BP2 mutations potentiate osteoclastogenesis via PLCγ.

SH3BP2 PLCG2

8.19e-06358220872577
Pubmed

SENP7 senses oxidative stress to sustain metabolic fitness and antitumor functions of CD8+ T cells.

RAG1 SENP7

8.19e-06358235143421
Pubmed

Maximal adjuvant activity of nasally delivered IL-1α requires adjuvant-responsive CD11c(+) cells and does not correlate with adjuvant-induced in vivo cytokine production.

RAG1 IL1R1

8.19e-06358222345651
Pubmed

Remodelling of the gut microbiota by hyperactive NLRP3 induces regulatory T cells to maintain homeostasis.

RAG1 IL1R1

1.64e-05458229196621
Pubmed

IkappaB kinase alpha kinase activity is required for self-renewal of ErbB2/Her2-transformed mammary tumor-initiating cells.

RAG1 CHUK

1.64e-05458217890319
Pubmed

IL-4 together with IL-1β induces antitumor Th9 cell differentiation in the absence of TGF-β signaling.

RAG1 IL1R1

1.64e-05458230914642
Pubmed

Increased myeloid cell responses to M-CSF and RANKL cause bone loss and inflammation in SH3BP2 "cherubism" mice.

RAG1 SH3BP2

1.64e-05458217218256
Pubmed

Identification of a novel Ran binding protein 2 related gene (RANBP2L1) and detection of a gene cluster on human chromosome 2q11-q12.

RGPD8 RGPD5

1.64e-0545829480752
Pubmed

Interleukin-1beta mediates the extra-intestinal thrombosis associated with experimental colitis.

RAG1 IL1R1

1.64e-05458220971730
Pubmed

Differentiation of inflammatory dendritic cells is mediated by NF-κB1-dependent GM-CSF production in CD4 T cells.

RAG1 IL1R1

1.64e-05458221421852
Pubmed

Antigen-driven T cell-macrophage interactions mediate the interface between innate and adaptive immunity in histidyl-tRNA synthetase-induced myositis.

RAG1 IL1R1

2.72e-05558237809058
Pubmed

Endogenous renal adiponectin drives gluconeogenesis through enhancing pyruvate and fatty acid utilization.

GCGR PCK1

2.72e-05558237848446
Pubmed

GM-CSF primes cardiac inflammation in a mouse model of Kawasaki disease.

RAG1 IL1R1

2.72e-05558227595596
Pubmed

Nlrp3-dependent IL-1β inhibits CD103+ dendritic cell differentiation in the gut.

RAG1 IL1R1

2.72e-05558229515025
Pubmed

Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity.

RAG1 IL1R1

2.72e-05558219501000
Pubmed

NLRP1 acts as a negative regulator of Th17 cell programming in mice and humans with autoimmune diabetes.

RAG1 IL1R1

2.72e-05558234038731
Pubmed

Roles of the C-terminal tyrosine residues of LAT in GPVI-induced platelet activation: insights into the mechanism of PLC gamma 2 activation.

RAG1 PLCG2

2.72e-05558217579183
Pubmed

Gain-of-function Pyrin mutations induce NLRP3 protein-independent interleukin-1β activation and severe autoinflammation in mice.

RAG1 IL1R1

2.72e-05558221600797
Pubmed

IL-17 mediates immunopathology in the absence of IL-10 following Leishmania major infection.

RAG1 IL1R1

2.72e-05558223555256
Pubmed

Peripheral Lymphoid Volume Expansion and Maintenance Are Controlled by Gut Microbiota via RALDH+ Dendritic Cells.

RAG1 IL1R1

4.08e-05658226885858
Pubmed

A lymphotoxin-driven pathway to hepatocellular carcinoma.

RAG1 CHUK

4.08e-05658219800575
Pubmed

Persistence of Systemic Murine Norovirus Is Maintained by Inflammatory Recruitment of Susceptible Myeloid Cells.

RAG1 IL1R1

4.08e-05658230392829
Pubmed

Coagulation factor V mediates inhibition of tissue factor signaling by activated protein C in mice.

F2RL1 F8

4.08e-05658226341257
Pubmed

Cutting edge: IL-17-secreting innate lymphoid cells are essential for host defense against fungal infection.

RAG1 IL1R1

4.08e-05658223255360
Pubmed

Mechanisms promoting translocations in editing and switching peripheral B cells.

RAG1 SH3BP2

4.08e-05658219587764
Pubmed

A role for nuclear factor kappa B/rel transcription factors in the regulation of the recombinase activator genes.

RAG1 CHUK

4.08e-05658215845455
Pubmed

Critical regulation of early Th17 cell differentiation by interleukin-1 signaling.

RAG1 IL1R1

4.08e-05658219362022
Pubmed

Interleukin-1beta induction of NFkappaB is partially regulated by H2O2-mediated activation of NFkappaB-inducing kinase.

IL1R1 CHUK

5.71e-05758216286467
Pubmed

Complex genomic rearrangements lead to novel primate gene function.

RGPD8 RGPD5

5.71e-05758215710750
Pubmed

Enhanced TLR-MYD88 signaling stimulates autoinflammation in SH3BP2 cherubism mice and defines the etiology of cherubism.

SH3BP2 IL1R1

5.71e-05758225220465
Pubmed

IL-10 engages macrophages to shift Th17 cytokine dependency and pathogenicity during T-cell-mediated colitis.

RAG1 IL1R1

7.60e-05858225607885
Pubmed

Microbiota regulate innate immune signaling and protective immunity against cancer.

RAG1 IL1R1

7.60e-05858233894128
Pubmed

Diet Diurnally Regulates Small Intestinal Microbiome-Epithelial-Immune Homeostasis and Enteritis.

RAG1 PER1

7.60e-05858232888430
Pubmed

IKKα-deficient lung adenocarcinomas generate an immunosuppressive microenvironment by overproducing Treg-inducing cytokines.

RAG1 CHUK

7.60e-05858235121655
Pubmed

Regulation of NK cell-mediated cytotoxicity by the adaptor protein 3BP2.

SH3BP2 PLCG2

7.60e-05858211390470
Pubmed

MyD88 Adaptor-Dependent Microbial Sensing by Regulatory T Cells Promotes Mucosal Tolerance and Enforces Commensalism.

RAG1 IL1R1

7.60e-05858226231118
Pubmed

Microbiota-dependent crosstalk between macrophages and ILC3 promotes intestinal homeostasis.

RAG1 IL1R1

9.77e-05958224625929
Pubmed

IL-33 induces IL-13-dependent cutaneous fibrosis.

RAG1 IL1R1

9.77e-05958220042577
Pubmed

MyD88 is critically involved in immune tolerance breakdown at environmental interfaces of Foxp3-deficient mice.

RAG1 IL1R1

9.77e-05958222466646
Pubmed

Daily Rhythms of TNFα Expression and Food Intake Regulate Synchrony of Plasmodium Stages with the Host Circadian Cycle.

RAG1 IL1R1

1.22e-041058229805094
Pubmed

An integrated approach identifies the molecular underpinnings of murine anterior visceral endoderm migration.

CER1 SEMA6D

1.22e-041058238843837
Pubmed

Critical requirement for BCR, BAFF, and BAFFR in memory B cell survival.

RAG1 CHUK

1.22e-041058233119032
Pubmed

The adaptor protein FADD protects epidermal keratinocytes from necroptosis in vivo and prevents skin inflammation.

RAG1 IL1R1

1.22e-041058222000287
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

CYLC1 NDUFA12 RGPD8 NUP98 IL1R1 F2RL1 PCK1 RYR2 CHUK RGPD5

1.24e-041442581035575683
Pubmed

Nox2 and Rac1 regulate H2O2-dependent recruitment of TRAF6 to endosomal interleukin-1 receptor complexes.

IL1R1 CHUK

1.49e-041158216354686
Pubmed

Ectoderm-targeted overexpression of the glucocorticoid receptor induces hypohidrotic ectodermal dysplasia.

GCGR CHUK

1.49e-041158215746257
Pubmed

The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival.

RAG1 PLCG2

1.49e-041158215728238
Pubmed

IL-1β suppresses innate IL-25 and IL-33 production and maintains helminth chronicity.

RAG1 IL1R1

1.49e-041158223935505
Pubmed

A conserved dendritic-cell regulatory program limits antitumour immunity.

RAG1 IL1R1

1.78e-041258232269339
Pubmed

The Nlrp3 Inflammasome Suppresses Colorectal Cancer Metastatic Growth in the Liver by Promoting Natural Killer Cell Tumoricidal Activity.

RAG1 IL1R1

1.78e-041258226384545
Pubmed

TLR9-independent CD8+ T cell responses in hepatic AAV gene transfer through IL-1R1-MyD88 signaling.

IL1R1 F8

1.78e-041258238053332
Pubmed

TNF-alpha-dependent loss of IKKbeta-deficient myeloid progenitors triggers a cytokine loop culminating in granulocytosis.

RAG1 IL1R1

2.11e-041358221464320
Pubmed

Reciprocal regulation of Wnt and Gpr177/mouse Wntless is required for embryonic axis formation.

CER1 WLS

2.11e-041358219841259
Pubmed

The Intermucosal Connection between the Mouth and Gut in Commensal Pathobiont-Driven Colitis.

RAG1 IL1R1

2.11e-041358232758418
Pubmed

Inflammasomes Coordinate Pyroptosis and Natural Killer Cell Cytotoxicity to Clear Infection by a Ubiquitous Environmental Bacterium.

RAG1 IL1R1

2.11e-041358226572063
Pubmed

Ankyrin-G induces nucleoporin Nup358 to associate with the axon initial segment of neurons.

RGPD8 NUP98

2.11e-041358231427429
Pubmed

Mast cell-dependent anorexia and hypothermia induced by mucosal activation of Toll-like receptor 7.

RAG1 IL1R1

2.11e-041358218480244
Pubmed

Lymphatic vessels interact dynamically with the hair follicle stem cell niche during skin regeneration in vivo.

PLXND1 WLS

2.46e-041458231475747
Pubmed

Club Cell TRPV4 Serves as a Damage Sensor Driving Lung Allergic Inflammation.

RAG1 F2RL1

2.83e-041558232130954
Pubmed

Germline genomic variants associated with childhood acute lymphoblastic leukemia.

ST6GALNAC3 RYR2

2.83e-041558219684603
Pubmed

Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity.

RAG1 IL1R1

3.66e-041758222297845
Pubmed

T-bet is a key modulator of IL-23-driven pathogenic CD4(+) T cell responses in the intestine.

RAG1 IL1R1

3.66e-041758227193261
Pubmed

Target gene analysis by microarrays and chromatin immunoprecipitation identifies HEY proteins as highly redundant bHLH repressors.

SEMA6D PLXND1

3.66e-041758222615585
Pubmed

A novel miR1983-TLR7-IFNβ circuit licenses NK cells to kill glioma cells, and is under the control of galectin-1.

RAG1 IL1R1

4.59e-041958234249474
Pubmed

Spontaneous atopic dermatitis in mice with a defective skin barrier is independent of ILC2 and mediated by IL-1β.

RAG1 IL1R1

4.59e-041958230937919
Pubmed

Porcn-dependent Wnt signaling is not required prior to mouse gastrulation.

CER1 WLS

5.09e-042058223760955
Pubmed

Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut.

RAG1 IL1R1 CHUK

5.46e-049558320568250
Pubmed

Use of expression data and the CGEMS genome-wide breast cancer association study to identify genes that may modify risk in BRCA1/2 mutation carriers.

PER1 PLCG2

6.18e-042258218095154
Pubmed

KLF13 is a genetic modifier of the Holt-Oram syndrome gene TBX5.

SEMA6D PLXND1

6.76e-042358228164238
Pubmed

A forward genetic screen reveals roles for Nfkbid, Zeb1, and Ruvbl2 in humoral immunity.

RAG1 PLCG2

6.76e-042358222761313
Pubmed

Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

NLGN3 ZFAT SEMA6D

6.91e-0410358310819331
Pubmed

Tarp regulates early Chlamydia-induced host cell survival through interactions with the human adaptor protein SHC1.

SH3BP2 PLCG2

7.37e-042458220624904
Pubmed

Lhx1 functions together with Otx2, Foxa2, and Ldb1 to govern anterior mesendoderm, node, and midline development.

CER1 SEMA6D

8.00e-042558226494787
Pubmed

O-GlcNAcylation of SPOP promotes carcinogenesis in hepatocellular carcinoma.

NDUFA12 NUP98 AGK LAP3

8.65e-0425458436604567
Pubmed

Regulation of hierarchical clustering and activation of innate immune cells by dendritic cells.

RAG1 IL1R1

8.66e-042658219006696
Pubmed

TIMMDC1/C3orf1 functions as a membrane-embedded mitochondrial complex I assembly factor through association with the MCIA complex.

NDUFA12 LAP3 PCK1

8.82e-0411258324344204
Pubmed

Regulator of sex-limitation (Rsl) encodes a pair of KRAB zinc-finger genes that control sexually dimorphic liver gene expression.

ZNF208 ZNF736

1.08e-032958214563677
Pubmed

Med12 is essential for early mouse development and for canonical Wnt and Wnt/PCP signaling.

CER1 NLGN3

1.15e-033058220630950
Pubmed

An improved smaller biotin ligase for BioID proximity labeling.

YEATS2 NUP98 RYR2

1.16e-0312358326912792
Pubmed

Role of human leukocyte antigen, killer-cell immunoglobulin-like receptors, and cytokine gene polymorphisms in leptospirosis.

KIR2DL4 IL1R1

1.57e-033558219683555
CoexpressionGSE24634_IL4_VS_CTRL_TREATED_NAIVE_CD4_TCELL_DAY5_UP

METTL1 FADS2 PLCG2 PLXND1 WLS IL1R1

4.81e-06200576M4633
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25|PBMC_fresh-frozen / Compartment, severity and other cell annotations on 10x 3' data (130k)

NUP98 PER1 RELL1 PLCG2 RGPD5

4.99e-061915851ecd9849d14d5ebf3daf610e83fb50820cafd3ed
ToppCellbackground-Endothelial_cells|World / Sample and Cell Type and Tumor Cluster (all cells)

ST6GALNAC3 PLXND1 F8 PCK1 FAM43A

5.52e-06195585c7d60dabfc7cb310e002cab10003dadfcc34fe33
DiseaseCognitive impairment

RYR2 DMXL1

1.79e-0411542HP_0100543
DiseasePolyarthritis, Juvenile, Rheumatoid Factor Positive

AOPEP PER1 FAXDC2

1.80e-03131543C4704862
DiseasePolyarthritis, Juvenile, Rheumatoid Factor Negative

AOPEP PER1 FAXDC2

1.80e-03131543C4552091
DiseaseJuvenile arthritis

AOPEP PER1 FAXDC2

1.80e-03131543C3495559
DiseaseJuvenile psoriatic arthritis

AOPEP PER1 FAXDC2

1.80e-03131543C3714758
DiseaseAutoinflammatory disorder

SH3BP2 PLCG2

1.88e-0335542C3860213

Protein segments in the cluster

PeptideGeneStartEntry
KIKAAHFFSTLKEWP

AGK

231

Q53H12
FKIIHISKKHRTWFF

SH3BP2

96

P78314
RHRWCELIVKHKFTK

AOPEP

746

Q8N6M6
HWSFRFPNILKEIKH

ANGEL2

196

Q5VTE6
KKFWHHFMFRKTPAS

CER1

131

O95813
FKSKHHLALSVKRLW

DMXL1

2581

Q9Y485
WNKFLLEHHKRSIPK

DCUN1D1

196

Q96GG9
PHIKFSEWKFKLFRV

RAG1

21

P15918
KRHKVWYKKFFHHLL

PGBD4

446

Q96DM1
AKLPKIFHVNWFRKD

PCK1

506

P35558
KWLKQLFHRLPHETS

RGPD5

456

Q99666
KWLKQLFHRLPHETS

RGPD8

456

O14715
KPLTARKFIWTNHKF

NDUFA12

101

Q9UI09
AFLKEFVTHPKWAHL

LAP3

466

P28838
SVYRKPKWNHLVHKF

FADS2

186

O95864
VPAKWIHEAKAVRAH

NUP98

1611

P52948
FLHHLQPFTWHEKIK

CHUK

221

O15111
HFLVHWFKKLSQKRF

HECTD2

266

Q5U5R9
FLKHWDHLTQVKKPV

ECHS1

116

P30084
HPWSRKVAFVLGRHK

PER1

446

O15534
PQFSTAKREKWIKHH

PLXND1

1176

Q9Y4D7
YWAFPSKALHARKHK

MND1

71

Q9BWT6
KPAHKWIRHSFRKIL

CYLC1

71

P35663
PWHHKVQHRFVFKRC

GCGR

86

P47871
RSVAKKHPKTWVHYI

F8

391

P00451
LHFGEKWFHKKVEKR

PLCG2

526

P16885
ILPFFLLHRWCSKKK

KIR2DL4

256

Q99706
ALWVFLFRTKKKHPA

F2RL1

96

P55085
YRATKVAFWKHLVPH

NLGN3

616

Q9NZ94
PTFYKKIHKKHHEWT

FAXDC2

196

Q96IV6
LFTSRKEHWIHFAPK

DNAH3

411

Q8TD57
HIKRHYHKKFWKLGA

GALNT3

11

Q14435
KVFAWVYRHELKHKA

FAM43A

151

Q8N2R8
HLPKRFSWFHSEFLK

KHDC3L

26

Q587J8
RLKQFHFHWGKKHDV

CA7

91

P43166
TVHLRKKHQFKWPSG

HINFP

361

Q9BQA5
VEHPQRSKKAVWHKL

RYR2

3576

Q92736
ASRIHQHKEKLWFVP

IL1R1

71

P14778
KKIWVPDVFFVHSKR

GABRR2

131

P28476
KPFDLRSKMGKWFHH

POTEC

16

B2RU33
KIATFTHPVFFWLKH

TAS2R60

121

P59551
HLEKWFPRHVIKTKR

SENP7

1016

Q9BQF6
DPKKALHHFRAIKKW

POLR1A

1061

O95602
LHHFRAIKKWQSKHP

POLR1A

1066

O95602
YKKKHLNVWPERHFK

TMC3

896

Q7Z5M5
RQKWPVKHIAVFHRL

MOCS2

111

O96007
GHRFITEKKVFAKWA

ST6GALNAC3

276

Q8NDV1
FAKWAKKHRIIFTHP

ST6GALNAC3

286

Q8NDV1
VWKKPFRFHPEHFLD

CYP2D7

426

A0A087X1C5
LQRHIWAHEGVKPFK

ZFAT

896

Q9P243
RHKRWHFIKPTNKSR

RELL1

196

Q8IUW5
KIWEHRSHHPSSKKI

TEX50

146

A0A1B0GTY4
AFSWLSVFSKHKKIH

ZNF208

1261

O43345
VDARKNHHKTKWFVP

WLS

51

Q5T9L3
IKYDSKWIKEPHFLH

SEMA6D

211

Q8NFY4
FPDPHFKRTKHKWRI

METTL1

161

Q9UBP6
SINHFVKKVWFFLHP

YEATS2

246

Q9ULM3
LTRHHWRIHSKEKPF

ZNF337

671

Q9Y3M9
AFKWFSALSKHKRIH

ZNF736

321

B4DX44
THKIWERFRPYKKHH

ELFN2

766

Q5R3F8