Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcessregulation of Wnt signaling pathway involved in heart development

LRP6 ALPK2

2.62e-0521062GO:0003307
GeneOntologyBiologicalProcessnegative regulation of Wnt signaling pathway involved in heart development

LRP6 ALPK2

2.62e-0521062GO:0003308
DomainRBD

RAF1 ARAF BRAF

3.22e-0661033PF02196
DomainRBD

RAF1 ARAF BRAF

5.61e-0671033SM00455
DomainRBD_dom

RAF1 ARAF BRAF

5.61e-0671033IPR003116
DomainRBD

RAF1 ARAF BRAF

5.61e-0671033PS50898
DomainWD40_repeat_dom

WDR36 COPB2 EML2 SPAG9 MAPK8IP3 WDR47 FZR1 EML1 WDR1 WDR49

5.69e-0629710310IPR017986
Domain-

WDR36 COPB2 EML2 SPAG9 MAPK8IP3 WDR47 FZR1 EML1 WDR1 WDR49

1.54e-05333103102.130.10.10
DomainWD40/YVTN_repeat-like_dom

WDR36 COPB2 EML2 SPAG9 MAPK8IP3 WDR47 FZR1 EML1 WDR1 WDR49

1.62e-0533510310IPR015943
DomainNatA_aux_su

NAA15 NAA16

3.01e-0521032IPR021183
DomainJIP_LZII

SPAG9 MAPK8IP3

3.01e-0521032IPR032486
DomainNARP1

NAA15 NAA16

3.01e-0521032PF12569
DomainJIP_LZII

SPAG9 MAPK8IP3

3.01e-0521032PF16471
DomainN2O_reductase_N

FZR1 EML1 WDR1

7.06e-05151033IPR011045
DomainWD40

WDR36 COPB2 EML2 WDR47 FZR1 EML1 WDR1 WDR49

9.37e-052591038PF00400
DomainWD40

WDR36 COPB2 EML2 WDR47 FZR1 EML1 WDR1 WDR49

1.19e-042681038SM00320
DomainWD40_repeat

WDR36 COPB2 EML2 WDR47 FZR1 EML1 WDR1 WDR49

1.31e-042721038IPR001680
DomainWD_REPEATS_1

WDR36 COPB2 EML2 WDR47 FZR1 EML1 WDR1 WDR49

1.53e-042781038PS00678
DomainWD_REPEATS_2

WDR36 COPB2 EML2 WDR47 FZR1 EML1 WDR1 WDR49

1.57e-042791038PS50082
DomainWD_REPEATS_REGION

WDR36 COPB2 EML2 WDR47 FZR1 EML1 WDR1 WDR49

1.57e-042791038PS50294
DomainKRAB

ZNF140 ZNF184 ZNF233 ZNF285 ZNF416 ZNF773 ZNF606 ZNF160 ZNF304

1.63e-043581039PS50805
DomainKRAB

ZNF140 ZNF184 ZNF233 ZNF285 ZNF416 ZNF773 ZNF606 ZNF160 ZNF304

1.63e-043581039PF01352
DomainApc4_WD40_dom

WDR36 WDR47 FZR1

1.73e-04201033IPR024977
DomainANAPC4_WD40

WDR36 WDR47 FZR1

1.73e-04201033PF12894
DomainJNK/Rab-associated_protein-1_N

SPAG9 MAPK8IP3

1.79e-0441032IPR019143
DomainJnk-SapK_ap_N

SPAG9 MAPK8IP3

1.79e-0441032PF09744
DomainDAG/PE-bd

RAF1 ARAF BRAF

2.02e-04211033IPR020454
DomainKRAB

ZNF140 ZNF184 ZNF233 ZNF285 ZNF416 ZNF773 ZNF606 ZNF160 ZNF304

2.04e-043691039SM00349
DomainQuinoprotein_ADH-like_supfam

WDR36 EML2 EML1 WDR1

2.08e-04531034IPR011047
DomainKRAB

ZNF140 ZNF184 ZNF233 ZNF285 ZNF416 ZNF773 ZNF606 ZNF160 ZNF304

2.08e-043701039IPR001909
DomainRH2

SPAG9 MAPK8IP3

2.98e-0451032PS51777
DomainRH1

SPAG9 MAPK8IP3

2.98e-0451032PS51776
DomainTPR-like_helical_dom

NAA15 COPB2 RMDN3 KDM6A ZMYND12 CFAP46 NAA16

3.08e-042331037IPR011990
Domain-

ZNF131 ZNF140 ZNF184 ZNF233 ZNF285 PRDM4 ZNF416 ZNF773 ZNF841 ZNF606 ZNF160 ZNF304

3.60e-04679103123.30.160.60
Domainzf-C2H2

ZNF131 ZNF140 ZNF184 ZNF233 ZNF285 PRDM4 ZNF416 ZNF773 ZNF841 ZNF606 ZNF160 ZNF304

4.32e-0469310312PF00096
DomainZnf_C2H2/integrase_DNA-bd

ZNF131 ZNF140 ZNF184 ZNF233 ZNF285 PRDM4 ZNF416 ZNF773 ZNF841 ZNF606 ZNF160 ZNF304

4.37e-0469410312IPR013087
DomainAlpha_kinase

TRPM7 ALPK2

4.45e-0461032PF02816
DomainMHCK_EF2_kinase

TRPM7 ALPK2

4.45e-0461032IPR004166
DomainHELP

EML2 EML1

4.45e-0461032PF03451
DomainALPHA_KINASE

TRPM7 ALPK2

4.45e-0461032PS51158
DomainAlpha_kinase

TRPM7 ALPK2

4.45e-0461032SM00811
DomainHELP

EML2 EML1

4.45e-0461032IPR005108
DomainPkinase_Tyr

RAF1 ERBB4 MATK ARAF BRAF

7.41e-041291035PF07714
DomainSer-Thr/Tyr_kinase_cat_dom

RAF1 ERBB4 MATK ARAF BRAF

1.00e-031381035IPR001245
Domain-

NAA15 RMDN3 KDM6A ZMYND12 CFAP46 NAA16

1.01e-0320710361.25.40.10
DomainZINC_FINGER_C2H2_2

ZNF131 ZNF140 ZNF184 ZNF233 ZNF285 PRDM4 ZNF416 ZNF773 ZNF841 ZNF606 ZNF160 ZNF304

1.15e-0377510312PS50157
DomainZINC_FINGER_C2H2_1

ZNF131 ZNF140 ZNF184 ZNF233 ZNF285 PRDM4 ZNF416 ZNF773 ZNF841 ZNF606 ZNF160 ZNF304

1.17e-0377710312PS00028
DomainZnf_C2H2-like

ZNF131 ZNF140 ZNF184 ZNF233 ZNF285 PRDM4 ZNF416 ZNF773 ZNF841 ZNF606 ZNF160 ZNF304

1.44e-0379610312IPR015880
DomainZnf_C2H2

ZNF131 ZNF140 ZNF184 ZNF233 ZNF285 PRDM4 ZNF416 ZNF773 ZNF841 ZNF606 ZNF160 ZNF304

1.59e-0380510312IPR007087
DomainZnF_C2H2

ZNF131 ZNF140 ZNF184 ZNF233 ZNF285 PRDM4 ZNF416 ZNF773 ZNF841 ZNF606 ZNF160 ZNF304

1.64e-0380810312SM00355
Domainzf-C2H2_6

ZNF140 ZNF184 ZNF416 ZNF773 ZNF841 ZNF606 ZNF160

1.78e-033141037PF13912
DomainWD40_repeat_CS

WDR36 WDR47 FZR1 WDR1 WDR49

2.15e-031641035IPR019775
DomainTPR_REGION

NAA15 KDM6A ZMYND12 CFAP46 NAA16

2.21e-031651035PS50293
DomainTPR

NAA15 KDM6A ZMYND12 CFAP46 NAA16

2.21e-031651035PS50005
Domain-

MRC1 HGFAC

2.26e-031310322.10.10.10
DomainFN_type2_col-bd

MRC1 HGFAC

2.62e-03141032IPR000562
DomainFN2_2

MRC1 HGFAC

2.62e-03141032PS51092
DomainATPase_dyneun-rel_AAA

MDN1 DNAH11

2.62e-03141032IPR011704
DomainFN2_1

MRC1 HGFAC

2.62e-03141032PS00023
Domainfn2

MRC1 HGFAC

2.62e-03141032PF00040
DomainFN2

MRC1 HGFAC

2.62e-03141032SM00059
DomainAAA_5

MDN1 DNAH11

2.62e-03141032PF07728
DomainKinase-like_dom

RAF1 ERBB4 TRPM7 MATK ACVR1B ARAF BRAF NEK11 ALPK2

3.06e-035421039IPR011009
DomainC1_1

RAF1 ARAF BRAF

3.84e-03571033PF00130
DomainAcyl_Trfase/lysoPLipase

PLA2G4D PNPLA6

3.88e-03171032IPR016035
DomainZF_DAG_PE_1

RAF1 ARAF BRAF

5.32e-03641033PS00479
DomainZF_DAG_PE_2

RAF1 ARAF BRAF

5.32e-03641033PS50081
PathwayREACTOME_SIGNALING_BY_MRAS_COMPLEX_MUTANTS

RAF1 ARAF BRAF

1.08e-058833M38999
PathwayKEGG_MEDICUS_REFERENCE_REGULATION_OF_GF_RTK_RAS_ERK_SIGNALING_MRAS_SHOC2_PP1_HOLOPHOSPHATASE

RAF1 ARAF BRAF

1.08e-058833M47933
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_KRAS_NRAS_TO_ERK_SIGNALING_PATHWAY

RAF1 ARAF BRAF

2.29e-0510833M47374
PathwayKEGG_MEDICUS_VARIANT_HRAS_OVEREXPRESSION_TO_ERK_SIGNALING_PATHWAY

RAF1 ARAF BRAF

2.29e-0510833M47420
PathwayKEGG_MEDICUS_REFERENCE_RAC_CDC42_PAK_ERK_SIGNALING_PATHWAY

RAF1 ARAF BRAF

2.29e-0510833M47735
PathwayKEGG_MEDICUS_VARIANT_RET_FUSION_KINASE_TO_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF BRAF

3.14e-0511833M47370
PathwayKEGG_MEDICUS_VARIANT_TRK_FUSION_KINASE_TO_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF BRAF

3.14e-0511833M47371
PathwayKEGG_MEDICUS_VARIANT_EML4_ALK_FUSION_KINASE_TO_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF BRAF

4.17e-0512833M47369
PathwayKEGG_MEDICUS_PATHOGEN_HBV_LHBS_TO_PKC_ERK_SIGNALING_PATHWAY

RAF1 ARAF BRAF

4.17e-0512833M47597
PathwayKEGG_MEDICUS_ENV_FACTOR_METALS_TO_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF BRAF

4.17e-0512833M47815
PathwayKEGG_MEDICUS_PATHOGEN_HCV_CORE_TO_ERK_SIGNALING_PATHWAY

RAF1 ARAF BRAF

5.39e-0513833M47589
PathwayKEGG_MEDICUS_VARIANT_BCR_ABL_FUSION_KINASE_TO_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF BRAF

6.84e-0514833M47364
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_KIT_TO_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF BRAF

6.84e-0514833M47365
PathwayKEGG_MEDICUS_VARIANT_DUPLICATION_OR_MUTATION_ACTIVATED_FLT3_TO_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF BRAF

6.84e-0514833M47366
PathwayKEGG_MEDICUS_VARIANT_AMPLIFIED_PDGFR_TO_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF BRAF

6.84e-0514833M47378
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_EGFR_TO_PLCG_ERK_SIGNALING_PATHWAY

RAF1 ARAF BRAF

6.84e-0514833M47383
PathwayKEGG_MEDICUS_VARIANT_EML4_ALK_FUSION_KINASE_TO_PLCG_ERK_SIGNALING_PATHWAY

RAF1 ARAF BRAF

6.84e-0514833M47384
PathwayKEGG_MEDICUS_VARIANT_MET_OVEREXPRESSION_TO_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF BRAF

6.84e-0514833M47488
PathwayREACTOME_MAP2K_AND_MAPK_ACTIVATION

RAF1 VWF ARAF BRAF

7.85e-0539834MM15272
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_MET_TO_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF BRAF

8.51e-0515833M47367
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_EGFR_TO_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF BRAF

8.51e-0515833M47375
PathwayKEGG_MEDICUS_REFERENCE_EGF_EGFR_PLCG_ERK_SIGNALING_PATHWAY

RAF1 ARAF BRAF

8.51e-0515833M47382
PathwayKEGG_MEDICUS_VARIANT_AMPLIFIED_FGFR_TO_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF BRAF

8.51e-0515833M47380
PathwayKEGG_MEDICUS_REFERENCE_CA2_PYK2_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF BRAF

8.51e-0515833M47592
PathwayKEGG_MEDICUS_PATHOGEN_HBV_HBX_TO_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF BRAF

8.51e-0515833M47593
PathwayKEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_FGF17_TO_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF BRAF

8.51e-0515833M47640
PathwayKEGG_MEDICUS_VARIANT_IGF2_OVEREXPRESSION_TO_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF BRAF

8.51e-0515833M47485
PathwayKEGG_MEDICUS_REFERENCE_HGF_MET_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF BRAF

8.51e-0515833M47473
PathwayKEGG_MEDICUS_REFERENCE_FLT3LG_FLT3_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF BRAF

8.51e-0515833M47474
PathwayKEGG_MEDICUS_REFERENCE_TGFA_EGFR_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF BRAF

8.51e-0515833M47480
PathwayKEGG_MEDICUS_VARIANT_EGF_OVEREXPRESSION_TO_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF BRAF

8.51e-0515833M47495
PathwayKEGG_MEDICUS_REFERENCE_EREG_EGFR_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF BRAF

8.51e-0515833M47496
PathwayKEGG_MEDICUS_REFERENCE_AREG_EGFR_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF BRAF

8.51e-0515833M47497
PathwayKEGG_MEDICUS_REFERENCE_KITLG_KIT_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF BRAF

8.51e-0515833M47472
PathwayKEGG_MEDICUS_PATHOGEN_HCMV_GB_TO_PDGFR_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF BRAF

8.51e-0515833M47535
PathwayKEGG_MEDICUS_PATHOGEN_HPV_E5_TO_EGFR_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF BRAF

8.51e-0515833M47531
PathwayREACTOME_MAP2K_AND_MAPK_ACTIVATION

RAF1 VWF ARAF BRAF

8.69e-0540834M27557
PathwayKEGG_MEDICUS_REFERENCE_EGF_EGFR_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF BRAF

1.04e-0416833M47363
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_FGFR3_TO_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF BRAF

1.04e-0416833M47373
PathwayKEGG_MEDICUS_REFERENCE_EGF_ERBB2_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF BRAF

1.04e-0416833M47381
PathwayKEGG_MEDICUS_REFERENCE_P4_PR_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF BRAF

1.04e-0416833M47804
PathwayKEGG_MEDICUS_ENV_FACTOR_E2_TO_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF BRAF

1.04e-0416833M47801
PathwayKEGG_MEDICUS_REFERENCE_IGF_IGF1R_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF BRAF

1.04e-0416833M47483
PathwayKEGG_MEDICUS_REFERENCE_AGE_RAGE_SIGNALING_PATHWAY

RAF1 ARAF BRAF

1.04e-0416833M47682
PathwayREACTOME_NEGATIVE_REGULATION_OF_MAPK_PATHWAY

RAF1 DUSP5 ARAF BRAF

1.05e-0442834MM15274
PathwayREACTOME_NEGATIVE_REGULATION_OF_MAPK_PATHWAY

RAF1 DUSP5 ARAF BRAF

1.16e-0443834M27560
PathwayKEGG_MEDICUS_REFERENCE_PDGF_PDGFR_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF BRAF

1.26e-0417833M47376
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_AGE_RAGE_SIGNALING_PATHWAY

RAF1 ARAF BRAF

1.26e-0417833M47684
PathwayREACTOME_SIGNALING_BY_MODERATE_KINASE_ACTIVITY_BRAF_MUTANTS

RAF1 VWF ARAF BRAF

1.39e-0445834M27623
PathwayWP_INHIBITION_OF_EXOSOME_BIOGENESIS_AND_SECRETION_BY_MANUMYCIN_A_IN_CRPC_CELLS

RAF1 ARAF BRAF

1.51e-0418833M39737
PathwayKEGG_MEDICUS_REFERENCE_CXCL12_CXCR4_PKC_ERK_SIGNALING_PATHAWAY

RAF1 ARAF BRAF

1.78e-0419833M47596
PathwayKEGG_MEDICUS_ENV_FACTOR_NNK_NNN_TO_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF BRAF

1.78e-0419833M47793
PathwayKEGG_MEDICUS_REFERENCE_GF_RTK_RAS_ERK_SIGNALING_PATHWAY

RAF1 ERBB4 ARAF BRAF NGF

2.06e-0492835M47927
PathwayKEGG_MEDICUS_REFERENCE_ACH_CHRN_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF BRAF

2.42e-0421833M47792
PathwayKEGG_MEDICUS_REFERENCE_E2_ER_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF BRAF

3.20e-0423833M47799
PathwayREACTOME_SIGNALLING_TO_P38_VIA_RIT_AND_RIN

BRAF NGF

3.39e-045832M17181
PathwayWP_MAPK_SIGNALING_PATHWAY

RAF1 DUSP5 ACVR1B MAPK8IP3 BRAF NGF

3.57e-04160836MM15990
PathwayWP_NOVEL_JUNDMP1_PATHWAY

RAF1 ARAF BRAF

4.12e-0425833MM15984
PathwayWP_PILOCYTIC_ASTROCYTOMA

RAF1 BRAF

5.06e-046832M39584
PathwayREACTOME_NEGATIVE_FEEDBACK_REGULATION_OF_MAPK_PATHWAY

RAF1 BRAF

5.06e-046832M27559
PathwayREACTOME_NEGATIVE_FEEDBACK_REGULATION_OF_MAPK_PATHWAY

RAF1 BRAF

5.06e-046832MM15273
PathwayREACTOME_P75NTR_NEGATIVELY_REGULATES_CELL_CYCLE_VIA_SC1

PRDM4 NGF

5.06e-046832M27072
PathwayREACTOME_SIGNALING_BY_BRAF_AND_RAF1_FUSIONS

RAF1 VWF ARAF BRAF

5.76e-0465834M38994
PathwayWP_MAPK_CASCADE

RAF1 ARAF BRAF

5.80e-0428833MM15976
PathwayWP_MELANOMA

RAF1 ERBB4 ARAF BRAF

6.83e-0468834M39811
PathwayREACTOME_ARMS_MEDIATED_ACTIVATION

BRAF NGF

7.06e-047832M621
PathwayKEGG_RENAL_CELL_CARCINOMA

CUL2 RAF1 ARAF BRAF

7.62e-0470834M13266
PathwayWP_MAPK_CASCADE

RAF1 ARAF BRAF

9.45e-0433833M39594
PathwayREACTOME_RAF_ACTIVATION

RAF1 ARAF BRAF

1.03e-0334833M27556
PathwayREACTOME_RAF_ACTIVATION

RAF1 ARAF BRAF

1.12e-0335833MM15271
PathwayKEGG_MEDICUS_REFERENCE_FGF_FGFR_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF BRAF

1.12e-0335833M47379
PathwayREACTOME_ONCOGENIC_MAPK_SIGNALING

RAF1 VWF ARAF BRAF

1.38e-0382834M27626
PathwayKEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION

RAF1 ARAF FZR1 BRAF

1.57e-0385834M3578
PathwayWP_BLADDER_CANCER

RAF1 ARAF BRAF

1.66e-0340833M39523
PathwayKEGG_ERBB_SIGNALING_PATHWAY

RAF1 ERBB4 ARAF BRAF

1.72e-0387834M12467
PathwayKEGG_BLADDER_CANCER

RAF1 ARAF BRAF

1.91e-0342833M19096
PathwayWP_ERBB_SIGNALING

RAF1 ERBB4 ARAF BRAF

2.11e-0392834M39715
PathwayREACTOME_GP1B_IX_V_ACTIVATION_SIGNALLING

RAF1 VWF

2.18e-0312832MM15093
PathwayREACTOME_GP1B_IX_V_ACTIVATION_SIGNALLING

RAF1 VWF

2.18e-0312832M27352
PathwayBIOCARTA_CDK5_PATHWAY

RAF1 NGF

2.56e-0313832M89
PathwayREACTOME_MAPK_FAMILY_SIGNALING_CASCADES

USP17L7 RAF1 ERBB4 VWF DUSP5 ARAF BRAF

2.67e-03318837MM15278
PathwayREACTOME_PROLONGED_ERK_ACTIVATION_EVENTS

BRAF NGF

2.98e-0314832M622
PathwayREACTOME_PROLONGED_ERK_ACTIVATION_EVENTS

BRAF NGF

2.98e-0314832MM14667
PathwayBIOCARTA_CDK5_PATHWAY

RAF1 NGF

2.98e-0314832MM1457
PathwayPID_TCR_RAS_PATHWAY

RAF1 BRAF

2.98e-0314832M134
PathwayWP_MAPK_SIGNALING

RAF1 PLA2G4D ARAF MAPK8IP3 BRAF NGF

3.27e-03246836M39597
Pubmed

AMPK Promotes SPOP-Mediated NANOG Degradation to Regulate Prostate Cancer Cell Stemness.

RAF1 ARAF KLHL22 BRAF

1.01e-089106430595535
Pubmed

RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth.

RAF1 ARAF BRAF

2.75e-083106320130576
Pubmed

Mutation analysis of the BRAF, ARAF and RAF-1 genes in human colorectal adenocarcinomas.

RAF1 ARAF BRAF

2.75e-083106314688025
Pubmed

Expression of raf family proto-oncogenes in normal mouse tissues.

RAF1 ARAF BRAF

2.75e-08310631690378
Pubmed

Endothelial apoptosis in Braf-deficient mice.

RAF1 ARAF BRAF

2.75e-08310639207797
Pubmed

Effects of Raf dimerization and its inhibition on normal and disease-associated Raf signaling.

RAF1 ARAF BRAF

2.75e-083106323352452
Pubmed

Overlapping and specific functions of Braf and Craf-1 proto-oncogenes during mouse embryogenesis.

RAF1 ARAF BRAF

2.75e-083106310704835
Pubmed

ARAF acts as a scaffold to stabilize BRAF:CRAF heterodimers.

RAF1 ARAF BRAF

2.75e-083106322926515
Pubmed

Activation of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase by G protein and tyrosine kinase oncoproteins.

RAF1 ARAF BRAF

1.10e-07410638394352
Pubmed

Selective activation of MEK1 but not MEK2 by A-Raf from epidermal growth factor-stimulated Hela cells.

RAF1 ARAF BRAF

1.10e-07410638621729
Pubmed

Aberrant expression of COT is related to recurrence of papillary thyroid cancer.

RAF1 ARAF BRAF

1.10e-074106325674762
Pubmed

B-Raf protein isoforms interact with and phosphorylate Mek-1 on serine residues 218 and 222.

RAF1 ARAF BRAF

1.10e-07410637731720
Pubmed

Functional characterization of a PROTAC directed against BRAF mutant V600E.

RAF1 ARAF BRAF

1.10e-074106332778845
Pubmed

Disruption of CRAF-mediated MEK activation is required for effective MEK inhibition in KRAS mutant tumors.

RAF1 ARAF BRAF

2.74e-075106324746704
Pubmed

Germline gain-of-function mutations in RAF1 cause Noonan syndrome.

RAF1 ARAF BRAF

2.74e-075106317603482
Pubmed

In vivo functions of mitogen-activated protein kinases: conclusions from knock-in and knock-out mice.

RAF1 ARAF BRAF

2.74e-075106317219248
Pubmed

Morphogenesis of the telencephalic commissure requires scaffold protein JNK-interacting protein 3 (JIP3).

SPAG9 MAPK8IP3 NRP1 STXBP1

3.80e-0720106412897243
Pubmed

Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1.

RAF1 ARAF BRAF

5.47e-07610638157000
Pubmed

Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.

CUL2 RAF1 ERBB4 MATK ACVR1B ARAF KLHL22 BRAF NEK11

2.19e-06372106922939624
Pubmed

Identification of novel in vivo phosphorylation sites of the human proapoptotic protein BAD: pore-forming activity of BAD is regulated by phosphorylation.

RAF1 ARAF BRAF

2.28e-069106319667065
Pubmed

A-raf and B-raf are dispensable for normal endochondral bone development, and parathyroid hormone-related peptide suppresses extracellular signal-regulated kinase activation in hypertrophic chondrocytes.

RAF1 ARAF BRAF

2.28e-069106317967876
Pubmed

Essential role of B-Raf in ERK activation during extraembryonic development.

RAF1 ARAF BRAF

3.25e-0610106316432225
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

CUL2 RAF1 NAA15 SSR4 ARAF NRP1 SMG8 IBTK RHPN2 NISCH DNA2

4.99e-066501061138777146
Pubmed

Targets of Raf in tumorigenesis.

RAF1 BRAF

9.20e-062106220047953
Pubmed

Mammalian Ras interacts directly with the serine/threonine kinase Raf.

RAF1 ARAF

9.20e-06210628334704
Pubmed

Elimination of B-RAF in oncogenic C-RAF-expressing alveolar epithelial type II cells reduces MAPK signal intensity and lung tumor growth.

RAF1 BRAF

9.20e-062106225096573
Pubmed

Increased BRAF heterodimerization is the common pathogenic mechanism for noonan syndrome-associated RAF1 mutants.

RAF1 BRAF

9.20e-062106222826437
Pubmed

In melanoma, RAS mutations are accompanied by switching signaling from BRAF to CRAF and disrupted cyclic AMP signaling.

RAF1 BRAF

9.20e-062106217018604
Pubmed

A-Raf and C-Raf differentially regulate mechanobiological response of osteoblasts to guide mechanical stress-induced differentiation.

RAF1 ARAF

9.20e-062106227240957
Pubmed

Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF.

RAF1 BRAF

9.20e-062106215035987
Pubmed

Overlapping roles of JIP3 and JIP4 in promoting axonal transport of lysosomes in human iPSC-derived neurons.

SPAG9 MAPK8IP3

9.20e-062106233788575
Pubmed

B-Raf and Raf-1 are regulated by distinct autoregulatory mechanisms.

RAF1 BRAF

9.20e-062106215710605
Pubmed

BRAF splice variants in rheumatoid arthritis synovial fibroblasts activate MAPK through CRAF.

RAF1 BRAF

9.20e-062106223517740
Pubmed

Truncated RAF kinases drive resistance to MET inhibition in MET-addicted cancer cells.

RAF1 BRAF

9.20e-062106225473895
Pubmed

Raf kinases in cancer-roles and therapeutic opportunities.

RAF1 BRAF

9.20e-062106221577205
Pubmed

Essential, non-redundant roles of B-Raf and Raf-1 in Ras-driven skin tumorigenesis.

RAF1 BRAF

9.20e-062106222733131
Pubmed

CRAF inhibition induces apoptosis in melanoma cells with non-V600E BRAF mutations.

RAF1 BRAF

9.20e-062106218794803
Pubmed

Sequence and expression patterns of a human EMAP-related protein-2 (HuEMAP-2).

EML2 EML1

9.20e-062106210521658
Pubmed

Structural characterization of the RH1-LZI tandem of JIP3/4 highlights RH1 domains as a cytoskeletal motor-binding motif.

SPAG9 MAPK8IP3

9.20e-062106231690808
Pubmed

Anaphase-Promoting Complex Adaptor FZR1/CDH1 Blocks BRAF Signaling Both by Targeting BRAF for Proteolytic Degradation and by Disrupting BRAF Dimerization.

FZR1 BRAF

9.20e-062106228373167
Pubmed

B-Raf and C-Raf are required for melanocyte stem cell self-maintenance.

RAF1 BRAF

9.20e-062106223022482
Pubmed

Identification of frequent BRAF copy number gain and alterations of RAF genes in Chinese prostate cancer.

RAF1 BRAF

9.20e-062106222833462
Pubmed

Rafs constitute a nodal point in the regulation of embryonic endothelial progenitor cell growth and differentiation.

RAF1 BRAF

9.20e-062106218205709
Pubmed

The role of mannosylated enzyme and the mannose receptor in enzyme replacement therapy.

MRC1 LIPA

9.20e-062106216380916
Pubmed

Histone 3 lysine-27 demethylase KDM6A coordinates with KMT2B to play an oncogenic role in NSCLC by regulating H3K4me3.

KMT2B KDM6A

9.20e-062106232879445
Pubmed

Epidermal RAF prevents allergic skin disease.

RAF1 BRAF

9.20e-062106227431613
Pubmed

RAF inhibitors activate the MAPK pathway by relieving inhibitory autophosphorylation.

RAF1 BRAF

9.20e-062106223680146
Pubmed

ERK MAP kinase signaling in post-mortem brain of suicide subjects: differential regulation of upstream Raf kinases Raf-1 and B-Raf.

RAF1 BRAF

9.20e-062106216172610
Pubmed

BRAF inactivation drives aneuploidy by deregulating CRAF.

RAF1 BRAF

9.20e-062106220978199
Pubmed

Active Ras induces heterodimerization of cRaf and BRaf.

RAF1 BRAF

9.20e-062106211325826
Pubmed

RAF inhibitors that evade paradoxical MAPK pathway activation.

RAF1 BRAF

9.20e-062106226466569
Pubmed

Griffipavixanthone, a dimeric xanthone extracted from edible plants, inhibits tumor metastasis and proliferation via downregulation of the RAF pathway in esophageal cancer.

RAF1 BRAF

9.20e-062106226646323
Pubmed

A-Raf and Raf-1 work together to influence transient ERK phosphorylation and Gl/S cell cycle progression.

RAF1 ARAF

9.20e-062106215856007
Pubmed

Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization.

RAF1 BRAF

9.20e-062106216364920
Pubmed

Super-resolution imaging reveals the nanoscale organization of metabotropic glutamate receptors at presynaptic active zones.

GRM4 STXBP1

9.20e-062106232494600
Pubmed

K27-linked ubiquitination of BRAF by ITCH engages cytokine response to maintain MEK-ERK signaling.

RAF1 ARAF BRAF

9.77e-0614106331015455
Pubmed

Raf Kinases Are Essential for Phosphate Induction of ERK1/2 Phosphorylation in Hypertrophic Chondrocytes and Normal Endochondral Bone Development.

RAF1 ARAF BRAF

9.77e-0614106328073913
Pubmed

KIF5B gene sequence variation and response of cardiac stroke volume to regular exercise.

CUL2 NRP1 SVIL

1.22e-0515106318984674
Pubmed

The Ras branch of small GTPases: Ras family members don't fall far from the tree.

RAF1 BRAF NGF

1.22e-0515106310712923
Pubmed

Signal transduction by the neurotrophin receptors.

RAF1 BRAF NGF

2.17e-051810639069267
Pubmed

Cross-talk between EphA2 and BRaf/CRaf is a key determinant of response to Dasatinib.

RAF1 BRAF

2.76e-053106224486585
Pubmed

The strength of interaction at the Raf cysteine-rich domain is a critical determinant of response of Raf to Ras family small GTPases.

RAF1 BRAF

2.76e-053106210454553
Pubmed

Distinct requirement for an intact dimer interface in wild-type, V600E and kinase-dead B-Raf signalling.

RAF1 BRAF

2.76e-053106222510884
Pubmed

B- and C-RAF display essential differences in their binding to Ras: the isotype-specific N terminus of B-RAF facilitates Ras binding.

RAF1 BRAF

2.76e-053106217635919
Pubmed

The scaffold protein JIP3 functions as a downstream effector of the small GTPase ARF6 to regulate neurite morphogenesis of cortical neurons.

SPAG9 MAPK8IP3

2.76e-053106220493856
Pubmed

Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF.

RAF1 BRAF

2.76e-053106220141835
Pubmed

ERK and PDE4 cooperate to induce RAF isoform switching in melanoma.

RAF1 BRAF

2.76e-053106221478863
Pubmed

JSAP1/JIP3 and JLP regulate kinesin-1-dependent axonal transport to prevent neuronal degeneration.

SPAG9 MAPK8IP3

2.76e-053106225571974
Pubmed

RAF1/BRAF dimerization integrates the signal from RAS to ERK and ROKα.

RAF1 BRAF

2.76e-053106228270557
Pubmed

Nilotinib and MEK inhibitors induce synthetic lethality through paradoxical activation of RAF in drug-resistant chronic myeloid leukemia.

RAF1 BRAF

2.76e-053106222169110
Pubmed

Differential regulation of SC1/PRDM4 and PRMT5 mediated protein arginine methylation by the nerve growth factor and the epidermal growth factor in PC12 cells.

PRDM4 NGF

2.76e-053106223831350
Pubmed

Dual-specificity phosphatase 5 controls the localized inhibition, propagation, and transforming potential of ERK signaling.

RAF1 DUSP5

2.76e-053106228053233
Pubmed

A scaffold protein in the c-Jun NH2-terminal kinase signaling pathways suppresses the extracellular signal-regulated kinase signaling pathways.

RAF1 MAPK8IP3

2.76e-053106211044439
Pubmed

CRAF gene fusions in pediatric low-grade gliomas define a distinct drug response based on dimerization profiles.

RAF1 BRAF

2.76e-053106228806393
Pubmed

Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers.

RAF1 BRAF

2.76e-053106223934108
Pubmed

Sorafenib inhibits non-small cell lung cancer cell growth by targeting B-RAF in KRAS wild-type cells and C-RAF in KRAS mutant cells.

RAF1 BRAF

2.76e-053106219638574
Pubmed

Molecular and clinical analysis of RAF1 in Noonan syndrome and related disorders: dephosphorylation of serine 259 as the essential mechanism for mutant activation.

RAF1 ARAF

2.76e-053106220052757
Pubmed

The histone chaperone Spt6 coordinates histone H3K27 demethylation and myogenesis.

SUPT6H KDM6A

2.76e-053106223503590
Pubmed

ERK and beyond: insights from B-Raf and Raf-1 conditional knockouts.

RAF1 BRAF

2.76e-053106216861903
Pubmed

C-Raf is required for the initiation of lung cancer by K-Ras(G12D).

RAF1 BRAF

2.76e-053106222043453
Pubmed

A YWHAZ Variant Associated With Cardiofaciocutaneous Syndrome Activates the RAF-ERK Pathway.

RAF1 BRAF

2.76e-053106231024343
Pubmed

Structure of the BRAF-MEK complex reveals a kinase activity independent role for BRAF in MAPK signaling.

RAF1 BRAF

2.76e-053106225155755
Pubmed

JSAP1 and JLP are required for ARF6 localization to the midbody in cytokinesis.

SPAG9 MAPK8IP3

2.76e-053106225130574
Pubmed

Modulation of kinase activity and oncogenic properties by alternative splicing reveals a novel regulatory mechanism for B-Raf.

RAF1 BRAF

2.76e-05310629733801
Pubmed

Diacylglycerol kinase eta augments C-Raf activity and B-Raf/C-Raf heterodimerization.

RAF1 BRAF

2.76e-053106219710016
Pubmed

Critical role of JSAP1 and JLP in axonal transport in the cerebellar Purkinje cells of mice.

SPAG9 MAPK8IP3

2.76e-053106226320416
Pubmed

Large-scale mapping of human protein-protein interactions by mass spectrometry.

CUL2 RAF1 RAB17 COPB2 NIPSNAP2 EML2 SPAG9 SSR4 ECHS1 ARAF RMDN3 IBTK BRAF RHPN2

3.63e-0512841061417353931
Pubmed

B-RAF kinase drives developmental axon growth and promotes axon regeneration in the injured mature CNS.

RAF1 BRAF NGF

4.06e-0522106324733831
Pubmed

A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.

CUL2 MRC1 UNC5B DUSP5 NRP1 LIPA SVIL CFAP46

4.18e-05415106816385451
Pubmed

Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis.

RAF1 ARAF BRAF

4.66e-0523106312620389
Pubmed

Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.

TRPC4AP KMT2B DUSP5 STXBP1 EML1 KDM6A

5.17e-05214106622199357
Pubmed

The APC/C E3 Ligase Complex Activator FZR1 Restricts BRAF Oncogenic Function.

FZR1 BRAF

5.50e-054106228174173
Pubmed

Identification of interaction between MEK2 and A-Raf-1.

RAF1 ARAF

5.50e-054106211909642
Pubmed

A novel group of spindle cell tumors defined by S100 and CD34 co-expression shows recurrent fusions involving RAF1, BRAF, and NTRK1/2 genes.

RAF1 BRAF

5.50e-054106230276917
Pubmed

Liver sinusoidal endothelial cells depend on mannose receptor-mediated recruitment of lysosomal enzymes for normal degradation capacity.

MRC1 CTSD

5.50e-054106219026003
Pubmed

The tumor suppressor DiRas3 forms a complex with H-Ras and C-RAF proteins and regulates localization, dimerization, and kinase activity of C-RAF.

RAF1 BRAF

5.50e-054106222605333
Pubmed

Mixed-lineage kinase 3 regulates B-Raf through maintenance of the B-Raf/Raf-1 complex and inhibition by the NF2 tumor suppressor protein.

RAF1 BRAF

5.50e-054106216537381
Pubmed

Noonan Syndrome with Multiple Lentigines

RAF1 BRAF

5.50e-054106220301557
Pubmed

Conserved linkage of neurotrophin-3 and von Willebrand factor on mouse chromosome 6.

RAF1 VWF

5.50e-05410628318738
Pubmed

Rheb inhibits C-raf activity and B-raf/C-raf heterodimerization.

RAF1 BRAF

5.50e-054106216803888
CytobandEnsembl 112 genes in cytogenetic band chr19q13

KMT2B EML2 IRF3 ZNF233 ZNF285 ZNF416 ZNF773 RHPN2 ZNF841 ZNF606 ZNF160 ZNF304

2.08e-05119210612chr19q13
GeneFamilyMitogen-activated protein kinase kinase kinases|RAF family

RAF1 ARAF BRAF

8.29e-0758031157
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF717 ZNF131 ZNF140 ZNF184 ZNF233 ZNF285 PRDM4 ZNF416 ZNF773 ZNF841 ZNF606 ZNF160 ZNF304

1.48e-05718801328
GeneFamilyWD repeat domain containing

WDR36 COPB2 EML2 WDR47 FZR1 EML1 WDR1 WDR49

2.06e-05262808362
GeneFamilyMitogen-activated protein kinase kinase kinases|RAF family

RAF1 ARAF BRAF

1.58e-0424803654
GeneFamilyN(alpha)-acetyltransferase subunits|GCN5 related N-acetyltransferases

NAA15 NAA16

1.24e-0312802660
GeneFamilyLipases|Arylacetamide deacetylase family

DAGLB LIPA

4.22e-0322802464
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NRP1 LRRIQ1 ATP13A3 NEK11 ALPK2 DNAH11

3.72e-061751056284fdc7a9d303636a637041846850d19d114861a
ToppCelldroplet-Heart-nan-3m|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRPM7 ZNF184 CEP350 IBTK ZBED6 KDM6A

3.84e-061761056749b47eac5436fa34e0d243ffbc6f1897f4e431e
ToppCellNS-moderate-d_16-33-Epithelial-Ciliated|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

ERBB4 LRRIQ1 WDR49 NEK11 CFAP46 DNAH11

5.12e-0618510565e689c2fb36ce3ac2adc8d15f67107f21cf68868
ToppCelldroplet-Lung-30m-Hematologic-myeloid-alveolar_macrophage-alveolar_macrophage|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MRC1 SLC9A4 LIPA ATP13A3 CTSD DNAH11

5.78e-06189105698f517af255ef234eefc3ed7e6c1d63331ab8af0
ToppCellPND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

VWF UNC5B NRP1 RHPN2 ATP13A3 CALCRL

5.78e-0618910569da012fdfa9a8d488cab710a463a1d70e89f990c
ToppCelldroplet-Lung-30m-Hematologic-myeloid-alveolar_macrophage|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MRC1 SLC9A4 LIPA ATP13A3 CTSD DNAH11

5.78e-061891056f7e9b6e6a4de297b660a5b6c9a62f860c147185e
ToppCellCOPD-Myeloid-Macrophage_Alveolar|Myeloid / Disease state, Lineage and Cell class

MRC1 NRP1 RMDN3 PNPLA6 SVIL WDR49

5.96e-0619010569fc763d65470ba8858b973689c4d4358faab7dd3
ToppCellPND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

VWF UNC5B NRP1 RHPN2 ATP13A3 CALCRL

6.14e-0619110563307dbccadb09c62b0e1c0235ec89bb294d748c3
ToppCell367C-Myeloid-Macrophage|367C / Donor, Lineage, Cell class and subclass (all cells)

MRC1 FOLR2 RMDN3 LIPA PNPLA6 CTSD

6.92e-06195105677cd831a5da5ab1751499db541f318faf925e527
ToppCellLAM-Myeloid-Macrophage|Myeloid / Condition, Lineage and Cell class

MRC1 RMDN3 LIPA PNPLA6 SVIL CTSD

7.33e-061971056355fe286609df2ded973952f1856bbc5f437cfd0
ToppCell10x3'2.3-week_12-13-Myeloid_macrophage-stroma-stromal_macrophage|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

MRC1 FOLR2 NRP1 LIPA ATP13A3 CTSD

7.55e-0619810569a89083280d4253f282300cdf1e61746d1f32407
ToppCellBronchial-10x5prime-Immune_Myeloid-Macrophage_alveolar-Macro_alveolar|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

MRC1 RMDN3 LIPA PNPLA6 SVIL CTSD

7.99e-062001056c439d4c62732ad660a60bc6577a4a6ca0f32a5b7
ToppCellSevere_COVID-19-Myeloid-MoAM4|Severe_COVID-19 / Disease group,lineage and cell class （2021.01.30）

MRC1 FOLR2 NRP1 LIPA PNPLA6 CTSD

7.99e-06200105630448a41ca64d6f0fedaff0b7a6670dd33cdf2c5
ToppCellBAL-Severe-Myeloid-MoAM-MoAM4-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

MRC1 FOLR2 NRP1 LIPA PNPLA6 CTSD

7.99e-0620010564f481d87e30195365900acb5d50641a9e7b2f462
ToppCellBAL-Severe-Myeloid-MoAM-MoAM4-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

MRC1 FOLR2 NRP1 LIPA PNPLA6 CTSD

7.99e-0620010565490393c5f54748f912676e19b58bd1320415a06
ToppCellCOVID-19-Myeloid-MoAM2,_CCL18|COVID-19 / Condition, Lineage and Cell class

MRC1 FOLR2 NRP1 LIPA PNPLA6 CTSD

7.99e-062001056b0a50622d00335843efad86bc56a1e910019984b
ToppCellBAL-Severe-Myeloid-MoAM-MoAM4|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

MRC1 FOLR2 NRP1 LIPA PNPLA6 CTSD

7.99e-062001056cf720d3973e79ffd4c6e763a7284799ced22a274
ToppCellBAL-Severe-Myeloid-MoAM-MoAM4|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

MRC1 FOLR2 NRP1 LIPA PNPLA6 CTSD

7.99e-062001056df821ac12953e44fcfedbbefb35a4976e406ccd6
ToppCell343B-Myeloid-Macrophage-SPP1+_Macrophage_4|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

MRC1 MATK ERVW-1 STXBP1 CTSD

1.71e-051351055c4d3c9eba2a85ac40fea5ecfcc2b442a472323d0
ToppCellmetastatic_Lymph_Node-Myeloid_cells-Alveolar_Mac|Myeloid_cells / Location, Cell class and cell subclass

MRC1 CCDC168 RMDN3 PNPLA6 WDR49

2.11e-051411055399380de5ea09e22fd128e3e55fffeffc4874c15
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Lmo1_Fam159b|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ERBB4 FREM1 NRP1 SVIL CALCRL

2.67e-0514810559205b26e0d042b342cc643cda0f4f3f8bb392d00
ToppCellE15.5-Mesenchymal-developing_mesenchymal_cell-mesenchymal_immature_unknown_1|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

VWF WDR47 GYG1 CALCRL ALPK2

3.23e-051541055e65e4636646164610f33f7bbac0d879a3ea55986
ToppCellEpithelial-Epithelial-B_(AT1-AT2-progenitors)|Epithelial / shred on cell class and cell subclass (v4)

ERBB4 UNC5B OTOP2 NRP1 MDN1

3.23e-051541055770712806e26f73456fb77a81aa4ef8ec78a21ea
ToppCellLPS-IL1RA+antiTNF-Epithelial_airway-Ciliated_cells|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SLC9A4 LRRIQ1 WDR49 CFAP46 DNAH11

3.33e-0515510555f1e2195a6b831e1b636f5cc3a282ca423721822
ToppCellmetastatic_Lymph_Node-Myeloid_cells-Alveolar_Mac|metastatic_Lymph_Node / Location, Cell class and cell subclass

MRC1 RMDN3 LIPA PNPLA6 CTSD

3.33e-05155105503fd443740272dcb547e39deaf7ae89b8307f241
ToppCellLPS-IL1RA+antiTNF-Epithelial_airway-Ciliated_cells-Ciliated|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SLC9A4 LRRIQ1 WDR49 CFAP46 DNAH11

3.33e-0515510550944429459f642a1bcc56edc1ec28aaecde3e2dc
ToppCell10x3'2.3-week_14-16-Myeloid_macrophage-stroma-erythroid_macrophage|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

MRC1 FOLR2 ERVW-1 NRP1 LIPA

4.23e-051631055240d9f0ea45e8b2c7173e7674fd740555810f9e7
ToppCellsaliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_B-B_cell-B_c01-TCL1A|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

LRRIQ1 WDR49 NEK11 CFAP46 DNAH11

4.88e-0516810559a8709d34865cfa668d8f3335dc34fc86fc32482
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LRRIQ1 WDR49 NEK11 CFAP46 DNAH11

5.02e-05169105514aadc2d1bf66eb47dac33b4d61ddb3c942caa4f
ToppCellE15.5-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_artery|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

VWF UNC5B NRP1 RHPN2 CALCRL

5.61e-051731055b0ff9808e38cb64a734ced498cd0546728746cd5
ToppCellE16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

VWF UNC5B NRP1 ATP13A3 CALCRL

6.09e-05176105577516048aefbe1f48e825052756df0c310c1c486
ToppCellE16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

VWF UNC5B NRP1 ATP13A3 CALCRL

6.09e-05176105596779273b94345250cf53ba671203345b43d9e00
ToppCellE18.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

VWF UNC5B NRP1 RHPN2 CALCRL

6.09e-05176105527e6b3ae41068d6cfdda3d46da7df2a27567140e
ToppCellE18.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

VWF UNC5B NRP1 RHPN2 CALCRL

6.09e-051761055d6a5470af9592f34a741265f2ea9651c05c3add3
ToppCellmetastatic_Lymph_Node-Myeloid_cells-Activated_DCs|metastatic_Lymph_Node / Location, Cell class and cell subclass

DUSP5 GCGR CEP350 CALCRL ALPK2

6.26e-051771055370aee11a6dc2c6f4366a13c3171f37bc5b32d65
ToppCell3'-Child09-12-SmallIntestine-Mesenchymal-Pericytes-Contractile_pericyte_(PLN+)|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ERBB4 NGF CAP2 ZMYND12 TLCD5

6.26e-051771055d731400997afea379f47ae8aa0f82802962b0861
ToppCell3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.3.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MRC1 NRP1 PNPLA6 SVIL CTSD

6.43e-0517810550b398656f26c4061b11ccf98908d0e2e1367585a
ToppCell10x3'2.3-week_14-16-Myeloid_macrophage-stroma-monocytoid_macrophage|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

MRC1 FOLR2 LIPA CTSD MASP2

6.43e-051781055e44b0aa82890ae84fc4d1343f1c65ae2fda69a11
ToppCellBAL-Mild-Myeloid-cDC-cDC-cDC_10|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

DUSP5 CALCRL CHST7 ALPK2 TLCD5

6.77e-05180105532d871738a24071b70084a7e80148a516110c78b
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c07-TYROBP|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

MATK ZNF184 ARAF PNPLA6 CTSD

6.77e-051801055557453b74d4a9cc95ed1c7b9a9a58e45eb02ed6a
ToppCellBAL-Mild-Myeloid-cDC-cDC-cDC_10|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

DUSP5 CALCRL CHST7 ALPK2 TLCD5

6.77e-051801055067ca8a15228c7f3b3bc7aecbc9b1611ca05e176
ToppCelldroplet-Lung-LUNG-30m-Myeloid-alveolar_macrophage|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MRC1 SLC9A4 LIPA ATP13A3 CTSD

6.95e-0518110558fcdab61fad2efd324d2b27c58f5a594f1dc15de
ToppCellCOVID-19-Heart-CM_3|Heart / Disease (COVID-19 only), tissue and cell type

PDE10A SVIL ATP13A3 ALPK2 CAP2

7.14e-051821055287fcc3897ae08841f6f85ae6c9cef16f75b1dd1
ToppCelldroplet-Lung-LUNG-30m-Myeloid-Alveolar_Macrophage|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MRC1 SLC9A4 LIPA ATP13A3 CTSD

7.14e-051821055be48ce85991bceeff938ba080e6bf9cc62176b05
ToppCelldroplet-Lung-18m-Hematologic-myeloid-alveolar_macrophage|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MRC1 SLC9A4 LIPA ATP13A3 CTSD

7.51e-0518410558fa30789c9d583188667cf375d2218e392dd40bc
ToppCellCOPD-Myeloid-Macrophage_Alveolar|World / Disease state, Lineage and Cell class

MRC1 NRP1 PNPLA6 SVIL WDR49

7.51e-0518410557fd0b227c3750ffb80e41e92c60fcce46656be14
ToppCelldroplet-Lung-18m-Hematologic-myeloid-alveolar_macrophage-alveolar_macrophage|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MRC1 SLC9A4 LIPA ATP13A3 CTSD

7.71e-0518510554bee178ede12f56ba5f5bec44a03dc2a62c50137
ToppCellNS-critical-d_16-33-Epithelial-Ciliated|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

LRRIQ1 WDR49 NEK11 CFAP46 DNAH11

7.91e-05186105576033438426d8f9c72cd6691a7baf92104c9f03d
ToppCellNS-moderate-d_07-13-Epithelial-Ciliated|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

LRRIQ1 WDR49 NEK11 CFAP46 DNAH11

7.91e-05186105585787ff207f109ec7e3c0f729ba9bda739c2fdc9
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8|GI_small-bowel / Manually curated celltypes from each tissue

TRPM7 BRAF ZBED6 ATP13A3 KDM6A

8.32e-051881055ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCellnormal_Lymph_Node-Myeloid_cells-mo-Mac|normal_Lymph_Node / Location, Cell class and cell subclass

MRC1 FOLR2 NRP1 LIPA CTSD

8.32e-051881055e83de94a9b47a6a90e98face887eae031a322af6
ToppCell3'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophage_CCL3+-Alveolar_macrophage_CCL3+_L.1.0.2.4|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MRC1 NRP1 RMDN3 PNPLA6 CTSD

8.53e-051891055a59025e82fabd9d60e2438dee85b2644478cc7c8
ToppCelldroplet-Lung-1m-Hematologic-myeloid-alveolar_macrophage-alveolar_macrophage|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MRC1 SLC9A4 LIPA ATP13A3 CTSD

8.53e-051891055b2542b6fcf7bc10d29158d42b03182a939ff135a
ToppCellE16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

VWF UNC5B NRP1 ATP13A3 CALCRL

8.53e-051891055feedac2751ed770f80bc56fec31662b5b3826f58
ToppCell368C-Myeloid-Macrophage|368C / Donor, Lineage, Cell class and subclass (all cells)

MRC1 RMDN3 LIPA PNPLA6 CTSD

8.53e-051891055e62355be0d136e2b7c739848022292e9c6af7392
ToppCellLPS-IL1RA+antiTNF-Endothelial-Endothelial-Artery|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

VWF UNC5B PDE10A ATP13A3 CALCRL

8.53e-051891055c45734970036e6d28d5e3fe7c9458fae38a3f624
ToppCellCOPD-Epithelial-Ciliated|Epithelial / Disease state, Lineage and Cell class

LRRIQ1 WDR49 NEK11 CFAP46 DNAH11

8.53e-0518910553e77883db34722b9ce0a03ea74caefc92dc7feff
ToppCellRV-15._Ventricular_Cardiomyocyte_III|RV / Chamber and Cluster_Paper

ERBB4 MAPK8IP3 SVIL ALPK2 CAP2

8.74e-05190105593c3188dfeb0b2f9889f8ae9b9c1f2f34129c99b
ToppCellCOPD-Myeloid-Macrophage_Alveolar|COPD / Disease state, Lineage and Cell class

MRC1 NRP1 RMDN3 PNPLA6 SVIL

8.74e-051901055006e31606d637033bc81333816ee332773d36b08
ToppCellNasal_Brush-Epithelial-Ciliated_2|Nasal_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X

LRRIQ1 WDR49 NEK11 CFAP46 DNAH11

8.74e-0519010559ce7df056bfb24d70db4c3c4a2c57d89115de877
ToppCellNasal_Brush-Epithelial-Ciliated_2|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X

LRRIQ1 WDR49 NEK11 CFAP46 DNAH11

8.74e-051901055833481ace2800354712e2ce709d5cdfd0aed3d42
ToppCell21-Trachea-Endothelial|Trachea / Age, Tissue, Lineage and Cell class

MRC1 VWF NRP1 CALCRL CHST7

8.74e-051901055bce09634acbc2cfd53666328e8aed8bf8835f845
ToppCelldroplet-Lung-1m-Hematologic-myeloid-alveolar_macrophage|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MRC1 SLC9A4 LIPA ATP13A3 CTSD

8.74e-051901055da58227565ad6a690828dd8554dd3670222f8582
ToppCell356C-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

MRC1 FOLR2 NRP1 LIPA CTSD

8.74e-051901055d541e076137cf7334bdb0ed69db2f9a27c668c65
ToppCellfacs-GAT-Fat-3m|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MRC1 TRPC4AP NISCH SVIL LRP6

8.74e-0519010551d92be1b41cff59e834a9d28868f554bd1f3e471
ToppCell21-Trachea-Endothelial-Endothelial|Trachea / Age, Tissue, Lineage and Cell class

MRC1 VWF NRP1 CALCRL CHST7

8.74e-05190105508437396a98ca9526f69c3a74bbf2929f3c68b8e
ToppCellnucseq-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

LRRIQ1 WDR49 NEK11 CFAP46 DNAH11

8.96e-051911055e417bf491f8b8d7838a61f7f4f6b1740ba97aa3f
ToppCellnucseq-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

LRRIQ1 WDR49 NEK11 CFAP46 DNAH11

8.96e-0519110559d31c8424d35bdc0c27188b68bfd0f731af3600b
ToppCellEndothelial-C|World / shred on cell class and cell subclass (v4)

VWF UNC5B NRP1 ATP13A3 CALCRL

8.96e-051911055bf203931f973098b79ec681d1dd0854419819e98
ToppCellnucseq-Epithelial-Epithelial_Airway|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

LRRIQ1 WDR49 NEK11 CFAP46 DNAH11

8.96e-0519110551c528f72c9ef3ef3a850b05e4a9715190832270c
ToppCellLV-04._Ventricular_Cardiomyocyte_I|LV / Chamber and Cluster_Paper

ERBB4 TRPM7 SVIL ALPK2 CAP2

9.18e-051921055ad19e2c1d36a0566c9b12ced10db78f4781c8ea6
ToppCellSevere-Myeloid-Macrophages-FABP4+|Severe / Condition, Lineage, Cell class and cell subclass

MRC1 NRP1 RMDN3 LIPA CTSD

9.18e-05192105530aad927ad40d8abaf9d0539bf8cb9d88d16f24d
ToppCellControl-Epithelial-Ciliated|Epithelial / Disease state, Lineage and Cell class

LRRIQ1 WDR49 NEK11 CFAP46 DNAH11

9.41e-0519310550e37d454f3735edd936ee9a5f5f516ac3aad400e
ToppCellCOVID-19-Heart-CM_+_EC_+_Pericyte|Heart / Disease (COVID-19 only), tissue and cell type

ERBB4 SVIL ATP13A3 ALPK2 CAP2

9.41e-051931055dd5378a1ef8eb0eda9a3aae62f3c2f3a1402bda0
ToppCellAdult-Endothelial-capillary_endothelial_cell_(Cap1)|Adult / Lineage, Cell type, age group and donor

VWF UNC5B PDE10A EML1 CALCRL

9.41e-05193105539c6c96a2a100b1b290a779d36cc6bc17245720b
ToppCellIPF-Epithelial-Ciliated|Epithelial / Disease state, Lineage and Cell class

LRRIQ1 WDR49 NEK11 CFAP46 DNAH11

9.41e-051931055ad58f5080e0ba65c845056ea6b79037b636e9c64
ToppCellIPF-Myeloid-Macrophage_Alveolar|World / Disease state, Lineage and Cell class

MRC1 RMDN3 LIPA PNPLA6 SVIL

9.41e-05193105503a43b6d235fd47488a6a61efc311a34b232c0f4
ToppCellmyeloid-macrophage|World / Lineage and Cell class

MRC1 FOLR2 NRP1 LIPA CTSD

9.41e-051931055b13e694123b87ed8ad1786feb996398ddd84e94b
ToppCell367C-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)|367C / Donor, Lineage, Cell class and subclass (all cells)

MRC1 FOLR2 NRP1 NISCH CTSD

9.64e-051941055e3688f4252aae5f849f025d7f453ff4c0c14590b
ToppCell3'-Child04-06-SmallIntestine-Hematopoietic-Myeloid-LYVE1+_Macrophage|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MRC1 FOLR2 NRP1 LIPA CTSD

9.64e-051941055ad72be9f6871b334e1f477d868c15e7792fadea5
ToppCellNS-critical-d_07-13-Epithelial-Ciliated|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

LRRIQ1 WDR49 NEK11 CFAP46 DNAH11

9.64e-0519410551ae8a10e508e672e6677f0e3c986ac30d05adeb3
ToppCellnormal_Lung|World / Location, Cell class and cell subclass

MRC1 RMDN3 PNPLA6 SVIL CTSD

9.64e-051941055affae83d7f982d18117f5b95705f09809f304b0b
ToppCell3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MRC1 RMDN3 LIPA PNPLA6 CTSD

9.64e-051941055412c2b8eb522da6c84f8b00d32d6f0bee555251f
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LRRIQ1 WDR49 NEK11 CFAP46 DNAH11

9.64e-0519410554a2c127c90d1fefe604fcb9e796577d21b489dd6
ToppCell390C-Myeloid-Macrophage|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

MRC1 FOLR2 NRP1 RMDN3 LIPA

9.87e-051951055ba494be431916d43c1d480f65bed674c0722c710
ToppCell3'-Pediatric_IBD-SmallIntestine-Hematopoietic-Myeloid-LYVE1+_Macrophage|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MRC1 FOLR2 NRP1 LIPA CTSD

9.87e-051951055c16479a10f5ca2e89aea1742dbc5cc4dc9f3ea88
ToppCellLAM-Myeloid-Macrophage|LAM / Condition, Lineage and Cell class

MRC1 RMDN3 LIPA PNPLA6 CTSD

9.87e-05195105585abe51e47b567e6edcadfbe8cf02c2f2f0bb133
ToppCellwk_20-22-Endothelial-Blood_vessel_endothelial-GRIA2+_arterial_endo|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

VWF UNC5B LRP6 ATP13A3 CALCRL

9.87e-051951055a432d69b0172211ee4d53675936a1dc9ce1ae1f0
ToppCellmoderate-Epithelial-Ciliated|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

LRRIQ1 WDR49 NEK11 CFAP46 DNAH11

9.87e-0519510553486eae5fdb062a75a907b896c9d7b396d2aa195
ToppCellmoderate-Epithelial-Ciliated|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

LRRIQ1 WDR49 NEK11 CFAP46 DNAH11

9.87e-051951055e80f5cdf0b18066b3e6c2f5452e58f101c67932c
ToppCell356C-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)|356C / Donor, Lineage, Cell class and subclass (all cells)

MRC1 FOLR2 NRP1 LIPA CTSD

9.87e-0519510559231e929657542b78a6480d44402866511129c7f
ToppCell3'_v3-Lung|World / Manually curated celltypes from each tissue

MRC1 UNC5B LIPA PNPLA6 CTSD

1.01e-041961055a04f8384b734ce67ec402e64bd891a6274f04744
ToppCellBAL-Control-cDC_10|Control / Compartment, Disease Groups and Clusters

DUSP5 CALCRL CHST7 DNAH11 TLCD5

1.01e-041961055c32b7b7e6a4781c19c30c6e32d5563f82355deb0
ToppCell3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.4.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MRC1 RMDN3 LIPA PNPLA6 CTSD

1.01e-041961055eb7d6bbfb766cdeaf5fe0f0bb66a5f491fd5ef26
ToppCellcritical-Epithelial-Ciliated|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

LRRIQ1 WDR49 NEK11 CFAP46 DNAH11

1.01e-04196105527b855c6e1ae44f16db998cf0e81bd686b9cee7e
ToppCell10x3'2.3-week_17-19-Myeloid_macrophage-stroma-stromal_macrophage|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

MRC1 FOLR2 NRP1 LIPA CTSD

1.01e-04196105588517bb92be2f05c1e1ad94af22ac10d8c5c13c7
ToppCellNS-control-d_0-4-Epithelial-Ciliated|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

LRRIQ1 WDR49 NEK11 CFAP46 DNAH11

1.01e-041961055d46ab80554dd3c1cc81e1938ea2acfd5e85c6d2a
ToppCell3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MRC1 RMDN3 LIPA PNPLA6 CTSD

1.01e-0419610552793ad692d49b3ee78a5cd2d8e0220bf5188a686
ToppCellIPF-Epithelial|IPF / Disease state, Lineage and Cell class

ERBB4 LRRIQ1 RHPN2 CFAP46 DNAH11

1.01e-04196105587d9881cfec461a5d89b688a83749b618c519485
ToppCell3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MRC1 RMDN3 LIPA PNPLA6 CTSD

1.01e-041961055aae79eafe5bc2c7de16958994a2fe97439d7bea1
Drugalpha-Santonin [481-06-1]; Down 200; 16.2uM; MCF7; HT_HG-U133A

SRD5A3 UNC5B EML2 ACVR1B KLHL22 PDE12 LRP6 MASP2 ZNF304

3.47e-0719810594353_DN
DrugCephapirin sodium salt [24356-60-3]; Down 200; 9uM; MCF7; HT_HG-U133A

ACTR8 ACVR1B FZR1 OVGP1 PDE12 LRP6 RPRD2 NEK11

3.85e-0619810586790_DN
DrugThr-Leu

RAF1 ARAF BRAF

2.03e-05121053CID004420322
DrugSulfamethoxazole [723-46-6]; Down 200; 15.8uM; MCF7; HT_HG-U133A

EML2 MAPK8IP3 KLHL22 CEP350 FZR1 OVGP1 PDE12

3.19e-0519310574690_DN
DrugAcenocoumarol [152-72-7]; Down 200; 11.4uM; MCF7; HT_HG-U133A

ACTR8 TRPC4AP KMT2B PDE12 SUPT6H SOCS5 SVIL

3.19e-0519310577232_DN
DrugAdenosine 5'-monophosphate monohydrate [18422-05-4]; Down 200; 11uM; MCF7; HT_HG-U133A

SPAG9 KLHL22 FZR1 PDE12 SVIL LRP6 ATP13A3

3.40e-0519510573237_DN
DrugCefotaxime sodium salt [64485-93-4]; Down 200; 8.4uM; PC3; HT_HG-U133A

TRPC4AP MAPK8IP3 FZR1 BRAF SUPT6H NGF ATP13A3

3.63e-0519710572072_DN
DrugStreptozotocin [18883-66-4]; Down 200; 15uM; MCF7; HT_HG-U133A

UNC5B MATK EML2 ACVR1B PNPLA6 SVIL LRP6

3.75e-0519810577193_DN
DrugTodralazine hydrochloride [3778-76-5]; Down 200; 14.8uM; MCF7; HT_HG-U133A

CUL2 ZNF140 DUSP5 MAPK8IP3 SUPT6H LRP6 NEK11

3.75e-0519810571677_DN
DrugAzaperone [1649-18-9]; Up 200; 12.2uM; MCF7; HT_HG-U133A

ACVR1B PDE10A KLHL22 FZR1 ZNF606 KDM6A ZNF304

3.87e-0519910577231_UP
DrugMeropenem [96036-03-2]; Down 200; 10.4uM; PC3; HT_HG-U133A

SPAG9 CEP350 PDE12 SUPT6H SVIL CTSD KDM6A

3.87e-0519910575824_DN
DrugRemoxipride Hydrochloride [73220-03-8]; Down 200; 9.8uM; MCF7; HT_HG-U133A

SRD5A3 EML2 ACVR1B MAPK8IP3 PDE12 SOCS5 EML1

3.87e-0519910575443_DN
DiseaseAdenocarcinoma of large intestine

ERBB4 MATK ARAF BRAF NEK11

1.75e-0596985C1319315
DiseaseNoonan syndrome with multiple lentigines

RAF1 BRAF

3.27e-053982cv:C0175704
Diseasecongenital heart disease (implicated_via_orthology)

USP17L7 NAA15 KMT2B NAA16

8.38e-0569984DOID:1682 (implicated_via_orthology)
Diseasecardiomyopathy (implicated_via_orthology)

RAF1 ERBB4 ARAF BRAF

9.37e-0571984DOID:0050700 (implicated_via_orthology)
DiseaseLeopard Syndrome 1

RAF1 BRAF

1.62e-046982C4551484
DiseasePilomyxoid astrocytoma

RAF1 BRAF

2.27e-047982C1519086
DiseaseCutaneous Melanoma

RAF1 ERBB4 BRAF

3.46e-0441983C0151779
DiseaseNoonan syndrome

RAF1 BRAF

3.87e-049982cv:C0028326
Diseasehigh grade glioma (implicated_via_orthology)

RAF1 ARAF BRAF

4.26e-0444983DOID:3070 (implicated_via_orthology)
DiseaseNoonan Syndrome 1

RAF1 BRAF

5.89e-0411982C4551602
DiseaseTurner Syndrome, Male

RAF1 BRAF

5.89e-0411982C0041409
DiseaseFemale Pseudo-Turner Syndrome

RAF1 BRAF

5.89e-0411982C1527404
Diseasecoronary artery disease

DAGLB HGFAC ERBB4 TRPC4AP TRPM7 MAPK8IP3 NRP1 LIPA ZBED6 RPRD2 EML1 TLCD5

6.00e-0411949812EFO_0001645
Diseaseneuroimaging measurement

MRC1 KMT2B EML2 MAPK8IP3 NRP1 LRRIQ1 RHPN2 EML1 CALCRL WDR1 DNAH11

8.46e-0410699811EFO_0004346
DiseasePneumoconiosis

OVGP1 CA1

9.68e-0414982C0032273
DiseaseBagassosis

OVGP1 CA1

9.68e-0414982C0004681
Diseaseneuronal ceroid lipofuscinosis (implicated_via_orthology)

ATP13A3 CTSD

9.68e-0414982DOID:14503 (implicated_via_orthology)
DiseaseRASopathy

RAF1 BRAF

1.11e-0315982cv:C5555857
Diseaset-tau:beta-amyloid 1-42 ratio measurement

UNC5B OVGP1 BRAF

1.40e-0366983EFO_0007708
Diseasevenous thromboembolism, fibrinogen measurement

HGFAC VWF ZNF160

1.46e-0367983EFO_0004286, EFO_0004623
DiseaseNoonan-Like Syndrome With Loose Anagen Hair

RAF1 BRAF

1.80e-0319982C3501846
DiseaseNoonan syndrome-like disorder with loose anagen hair

RAF1 BRAF

1.80e-0319982C1843181
DiseaseCardio-facio-cutaneous syndrome

RAF1 BRAF

1.80e-0319982C1275081
DiseaseCostello syndrome (disorder)

RAF1 BRAF

1.80e-0319982C0587248
Diseaseprostate cancer (is_marker_for)

RAF1 ERBB4 KMT2B KDM6A

1.85e-03156984DOID:10283 (is_marker_for)
Diseaseprostate adenocarcinoma (is_implicated_in)

RAF1 BRAF

2.00e-0320982DOID:2526 (is_implicated_in)
Diseasevenous thromboembolism, plasminogen activator inhibitor 1 measurement

VWF ZNF160

2.20e-0321982EFO_0004286, EFO_0004792
Diseasebrain connectivity measurement

ERBB4 NRP1 LRRIQ1 RPRD2 EML1 CALCRL

2.21e-03400986EFO_0005210
DiseaseColorectal Carcinoma

TRPM7 OTOP2 EML2 OVGP1 BRAF RHPN2 KDM6A WDR49

2.37e-03702988C0009402
DiseaseLEOPARD Syndrome

RAF1 BRAF

2.42e-0322982C0175704
DiseaseOvarian Serous Adenocarcinoma

RAF1 TRPM7

2.64e-0323982C1335177
Diseasevenous thromboembolism, tissue plasminogen activator measurement

VWF ZNF160

2.64e-0323982EFO_0004286, EFO_0004791
Diseaseneuroimaging measurement, brain volume measurement

MRC1 ZNF184 RHPN2 EML1 CALCRL

2.69e-03286985EFO_0004346, EFO_0006930
DiseaseNoonan Syndrome

RAF1 BRAF

2.87e-0324982C0028326
Diseasehepatocellular carcinoma (is_implicated_in)

ERBB4 KMT2B SPAG9 KDM6A

3.16e-03181984DOID:684 (is_implicated_in)
Diseaseaspartate aminotransferase measurement

MRC1 HGFAC TRPM7 LIPA NGF CALCRL HEPHL1 CTSD ALPK2

3.16e-03904989EFO_0004736
DiseaseS-6-hydroxywarfarin to S-warfarin ratio measurement

SPAG9 WDR1 DNA2

3.18e-0388983EFO_0803332

Protein segments in the cluster

PeptideGeneStartEntry
CIHYRKFTHQSDVWS

ERBB4

891

Q15303
AIVTQWCEGSSLYHH

BRAF

526

P15056
HWVYQKTSGCLLVTD

ALPK2

2066

Q86TB3
KINWHYADSLTQCSH

ATP13A3

786

Q9H7F0
CSGNKWTNTSHHPEY

ACTR8

151

Q9H981
KWSCSQVFEGHTHYV

COPB2

131

P35606
TQLWLVSDYHEHGSL

ACVR1B

276

P36896
SAEYKVIGSWTDHLH

GRM4

486

Q14833
TYLCAKAWHHTVSVD

CFAP46

546

Q8IYW2
HTICLIWSHSKFYNT

DNAH11

366

Q96DT5
TQWCEGSSLYKHLHV

RAF1

421

P04049
IWDTAGQEKYHSVCH

RAB17

71

Q9H0T7
HEDKHYPCTLVGTWN

NIPSNAP2

101

O75323
LYVHSSVAQWRKCLH

SPAG9

981

O60271
DVSLHFVLWGCLHVY

PNPLA6

546

Q8IY17
DIYIQLTGEKHHSWS

MDN1

501

Q9NU22
CENKSWYRVKHHTSG

MATK

81

P42679
YVHSAVANWKKCLHS

MAPK8IP3

981

Q9UPT6
GIDSKHWNSYCTTTH

NGF

191

P01138
HRSIFYGHIDCVWSL

IBTK

91

Q9P2D0
YGHIDCVWSLLKHGV

IBTK

96

Q9P2D0
WHCESNRSHTTIAKY

KDM6A

1021

O15550
QAYIKEHHTTGLTWS

CAP2

196

P40123
CYSSKFLKHWDHLTQ

ECHS1

111

P30084
LKWLSYCQTHTVTHS

OR51D1

176

Q8NGF3
LYRHWGKEAFCLSHQ

PDE10A

206

Q9Y233
SSKRICVANTHLYWH

PDE12

446

Q6L8Q7
DVKSHVCWHVYGLLQ

NAA16

76

Q6N069
SGYCHILITEQKGTW

FREM1

2061

Q5H8C1
WKLYGDQCHHNLSLL

GCGR

36

P47871
HQGYDTKSDIWSLAC

NEK11

206

Q8NG66
DWSTHSILACNKYTG

LRP6

241

O75581
LLLESQWHHYSGEAS

KMT2B

2376

Q9UMN6
GSAHRKWCATTHNYD

HGFAC

126

Q04756
DLKSHVCWHVYGLLQ

NAA15

76

Q9BXJ9
ISHLYWNCGLESLKN

LRRIQ1

956

Q96JM4
SHHLQTVLFWTCEKY

MAB21L3

281

Q8N8X9
TYFLWVSAKDCVHVH

OTOP2

151

Q7RTS6
HSYHPSEKCEWLIQA

NRP1

46

O14786
IWSSAHQYKCHVILG

SRD5A3

211

Q9H8P0
AWSKHANELVSTHGY

FZR1

406

Q9UM11
ITQWCEGSSLYHHLH

ARAF

381

P10398
GVTLTKLHCWSLTQY

GYG1

81

P46976
KETHCYDPGSNTWHT

KLHL22

461

Q53GT1
CSAAHYSAKWSHEAE

DAGLB

611

Q8NCG7
SAELHVAHWNSAKYS

CA1

116

P00915
ACWIHHKYNSDKSST

CTSD

116

P07339
QHFSGRKLTWLHYLC

CUL2

546

Q13617
PIKSHQHCYSWSDES

CEP350

2021

Q5VT06
ALCEGLWSHSYKVSN

FOLR2

181

P14207
CLTWVYHSHIDAPKD

HEPHL1

181

Q6MZM0
MSWQTLCHLGLHYTE

MBOAT4

91

Q96T53
YSHWILDDSLLHAAG

MBOAT4

256

Q96T53
HTGWKIHYTSTAQPC

MASP2

286

O00187
SQFLTCGHDKHATLW

EML1

556

O00423
KCSGHSSFITHLDWA

EML2

501

O95834
SHWDHDYSCTHSKGK

CCDC168

6956

Q8NDH2
QHLKQTHLEYFSLWC

DNA2

431

P51530
YICSGSLIHHQWVLT

PRSS46P

66

E5RG02
SWCIENKKHHSTIVY

RPRD2

46

Q5VT52
SEACATHLHYKWIPV

DUSP5

216

Q16690
NCWISSDTHLLYIIH

CALCRL

281

Q16602
NHIWKIYHNGVLEFC

PRDM4

461

Q9UKN5
AHKLVCYFTNWAHSR

OVGP1

21

Q12889
LHQDYCSHKDFSTWA

PLA2G4D

611

Q86XP0
LGHCHTYWAVSEELL

IRF3

286

Q14653
ALSYLHSHSCHIKTW

MROH5

1241

Q6ZUA9
WHEAETYCKLHNSLI

MRC1

1116

P22897
LHEDCYKFWSNGHQL

SMG8

551

Q8ND04
HFLLGRWCYQVSHLS

RMDN3

366

Q96TC7
ATLCMHANTHYWTGK

ERVW-1

76

Q9UQF0
WQQHYLHKDKDSTCL

TRPC4AP

736

Q8TEL6
AWKVHTQIDYIHCLV

SOCS5

356

O75159
LIYLWHGCKAQAHTK

SVIL

1921

O95425
LKAGIEDVCGHWSHY

SLC9A4

501

Q6AI14
NVFYGHHAKIVCLAW

WDR1

526

O75083
STTAVSARYGHWHKN

STXBP1

511

P61764
WASLACVKAHHYAAL

RHPN2

341

Q8IUC4
KQHIYVHATWRTGSS

CHST7

101

Q9NS84
HLTVTWKVSDGIYQH

SUPT6H

1366

Q7KZ85
RNKHHKGSIYCVAWS

WDR47

656

O94967
ISFCHLNKHRSYEWS

TLCD5

21

Q6ZRR5
SHWRIHTGEKPYKCN

ZNF160

386

Q9HCG1
AYAHVCAQHGKVVTW

VWF

1106

P04275
YQVSWSLDHKSAHAG

SSR4

86

P51571
VKIWDFNGYCHHTLN

WDR49

216

Q8IV35
QVTDGSHEWTVKHRY

NISCH

36

Q9Y2I1
AVIALSRTCDYKHHW

PLPP5

196

Q8NEB5
WEHGHVLCASVNYLR

PROKR2

121

Q8NFJ6
WASLACVKAHHYTAL

RHPN2P1

256

A8MT19
HIWSGSQKALHCTFT

UNC5B

781

Q8IZJ1
YCGVVHQKADWDSIH

ZMYND12

36

Q9H0C1
CGKFYSHKSSLINHW

ZNF773

336

Q6PK81
IHQWTHTGEKPYECN

ZNF717

496

Q9BY31
RHWSIHTGEKPYKCN

ZNF841

666

Q6ZN19
KWLLEHCYSVHHSLG

ZBED6

656

P86452
EAFHVGISHYKWSQC

ZNF416

206

Q9BWM5
ECGKVFTWHASLIQH

ZNF140

361

P52738
ECRKGFIWNSYLHVH

ZNF233

596

A6NK53
WRSQIKYLHCHGVSD

USP17L7

201

P0C7H9
CGKFFSQSSHLIEHW

ZNF304

396

Q9HCX3
SAWKQHLNCYHLEEG

ZNF131

301

P52739
KGLSYLSQEVLHCWQ

ZNF285

61

Q96NJ3
CTWSEHDILKSGHLY

TRPM7

1631

Q96QT4
SYWSSLAQHLKIHTG

ZNF184

456

Q99676
ECGKSFSWSSHLIAH

ZNF606

516

Q8WXB4
SHVDHLGIYLWSNIS

WDR36

681

Q8NI36
QSAFLKWLGTHVCTH

LIPA

236

P38571