Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionmicrofilament motor activity

MYH2 MYH4 MYH7 MYH8 MYO15A

4.75e-06381315GO:0000146
GeneOntologyMolecularFunctioncytoskeletal motor activity

DNHD1 MYH2 MYH4 MYH7 MYH8 KIF23 MYO15A

1.28e-051181317GO:0003774
GeneOntologyMolecularFunctionbone sialoprotein binding

ANXA2 ANXA2P2

4.27e-0521312GO:0044730
GeneOntologyMolecularFunctionATP-dependent activity

DDX47 DNHD1 MYH2 MYH4 ABCC4 MYH7 MYH8 KIF23 ATP6V0A1 MACF1 SLFN11 MYO15A SLC27A3 HSP90AB3P

5.22e-0561413114GO:0140657
GeneOntologyMolecularFunctionbeta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3- sialyltransferase

ST3GAL1 ST3GAL2

1.28e-0431312GO:0047288
GeneOntologyMolecularFunctionphospholipase A2 inhibitor activity

ANXA2 ANXA2P2

4.22e-0451312GO:0019834
GeneOntologyMolecularFunctiontRNA (cytidine-5-)-methyltransferase activity

NSUN2 TRDMT1

4.22e-0451312GO:0016428
GeneOntologyMolecularFunctionNAD+-protein-cysteine ADP-ribosyltransferase activity

TIPARP PARP12

6.30e-0461312GO:0140803
GeneOntologyMolecularFunctionglycosyltransferase activity

B3GALNT1 FUT10 ST3GAL1 ST3GAL2 GTDC1 TIPARP POFUT1 PARP12

6.36e-042881318GO:0016757
GeneOntologyMolecularFunctionactin filament binding

MYH2 MYH4 MYH7 MYH8 TULP1 MACF1 MYO15A

7.58e-042271317GO:0051015
GeneOntologyMolecularFunctionbeta-galactoside (CMP) alpha-2,3-sialyltransferase activity

ST3GAL1 ST3GAL2

8.78e-0471312GO:0003836
GeneOntologyBiologicalProcessmuscle filament sliding

MYH2 MYH4 MYH7 MYH8

1.83e-06151284GO:0030049
GeneOntologyBiologicalProcessactin-myosin filament sliding

MYH2 MYH4 MYH7 MYH8

4.05e-06181284GO:0033275
GeneOntologyBiologicalProcesspositive regulation of low-density lipoprotein particle receptor binding

ANXA2 ANXA2P2

3.82e-0521282GO:1905597
GeneOntologyBiologicalProcesspositive regulation of receptor-mediated endocytosis involved in cholesterol transport

ANXA2 ANXA2P2

1.14e-0431282GO:1905602
GeneOntologyBiologicalProcessnegative regulation of low-density lipoprotein particle receptor catabolic process

ANXA2 ANXA2P2

1.14e-0431282GO:0032804
GeneOntologyBiologicalProcesstRNA decay

NSUN2 SLFN11 TRDMT1

1.78e-04181283GO:0016078
GeneOntologyBiologicalProcesspositive regulation of low-density lipoprotein particle clearance

ANXA2 ANXA2P2

2.27e-0441282GO:1905581
GeneOntologyBiologicalProcessnegative regulation of receptor catabolic process

ANXA2 ANXA2P2

2.27e-0441282GO:2000645
GeneOntologyBiologicalProcesstRNA stabilization

NSUN2 TRDMT1

2.27e-0441282GO:0036416
GeneOntologyBiologicalProcessnegative regulation of tRNA metabolic process

NSUN2 TRDMT1

2.27e-0441282GO:1903327
GeneOntologyBiologicalProcessnegative regulation of tRNA catabolic process

NSUN2 TRDMT1

2.27e-0441282GO:1902371
GeneOntologyBiologicalProcesspositive regulation of intracellular cholesterol transport

ANXA2 ANXA2P2

2.27e-0441282GO:0032385
GeneOntologyBiologicalProcesspositive regulation of intracellular sterol transport

ANXA2 ANXA2P2

2.27e-0441282GO:0032382
GeneOntologyBiologicalProcessprotein sialylation

ST3GAL1 ST3GAL2

2.27e-0441282GO:1990743
GeneOntologyBiologicalProcesspositive regulation of plasma membrane repair

ANXA2 ANXA2P2

3.77e-0451282GO:1905686
GeneOntologyBiologicalProcessregulation of low-density lipoprotein particle receptor binding

ANXA2 ANXA2P2

3.77e-0451282GO:1905595
GeneOntologyBiologicalProcessregulation of tRNA stability

NSUN2 TRDMT1

3.77e-0451282GO:0036415
GeneOntologyBiologicalProcessregulation of tRNA catabolic process

NSUN2 TRDMT1

3.77e-0451282GO:1902370
GeneOntologyBiologicalProcessdermatan sulfate biosynthetic process

UST DSEL

3.77e-0451282GO:0030208
GeneOntologyBiologicalProcesspositive regulation of intracellular lipid transport

ANXA2 ANXA2P2

3.77e-0451282GO:0032379
GeneOntologyBiologicalProcessglycoprotein biosynthetic process

B3GALNT1 FUT10 SRD5A3 ST3GAL1 ST3GAL2 UST LIPC POFUT1 DSEL

3.94e-043571289GO:0009101
GeneOntologyCellularComponentmuscle myosin complex

MYH2 MYH4 MYH7 MYH8

2.45e-06161304GO:0005859
GeneOntologyCellularComponentmyosin filament

MYH2 MYH4 MYH7 MYH8

1.63e-05251304GO:0032982
GeneOntologyCellularComponentmyosin II complex

MYH2 MYH4 MYH7 MYH8

2.60e-05281304GO:0016460
GeneOntologyCellularComponentmyosin complex

MYH2 MYH4 MYH7 MYH8 MYO15A

3.29e-05591305GO:0016459
GeneOntologyCellularComponentAnxA2-p11 complex

ANXA2 ANXA2P2

1.15e-0431302GO:1990665
GeneOntologyCellularComponentPCSK9-AnxA2 complex

ANXA2 ANXA2P2

1.15e-0431302GO:1990667
GeneOntologyCellularComponentmyelin sheath adaxonal region

ANXA2 ANXA2P2

7.90e-0471302GO:0035749
DomainDHR-1_domain

DOCK11 DOCK9 DOCK5 DOCK6

6.28e-07111264IPR027007
DomainDHR_2

DOCK11 DOCK9 DOCK5 DOCK6

6.28e-07111264PS51651
DomainDHR_1

DOCK11 DOCK9 DOCK5 DOCK6

6.28e-07111264PS51650
DomainDHR-2

DOCK11 DOCK9 DOCK5 DOCK6

6.28e-07111264PF06920
DomainDOCK

DOCK11 DOCK9 DOCK5 DOCK6

6.28e-07111264IPR026791
DomainDOCK_C

DOCK11 DOCK9 DOCK5 DOCK6

6.28e-07111264IPR010703
DomainDOCK-C2

DOCK11 DOCK9 DOCK5 DOCK6

6.28e-07111264PF14429
DomainDHR-2

DOCK11 DOCK9 DOCK5 DOCK6

6.28e-07111264IPR027357
DomainMyosin_N

MYH2 MYH4 MYH7 MYH8

2.54e-06151264PF02736
DomainMyosin_N

MYH2 MYH4 MYH7 MYH8

2.54e-06151264IPR004009
DomainMyosin_head_motor_dom

MYH2 MYH4 MYH7 MYH8 MYO15A

5.42e-06381265IPR001609
DomainMYOSIN_MOTOR

MYH2 MYH4 MYH7 MYH8 MYO15A

5.42e-06381265PS51456
DomainMyosin_head

MYH2 MYH4 MYH7 MYH8 MYO15A

5.42e-06381265PF00063
DomainMYSc

MYH2 MYH4 MYH7 MYH8 MYO15A

5.42e-06381265SM00242
DomainMyosin_tail_1

MYH2 MYH4 MYH7 MYH8

5.62e-06181264PF01576
DomainMyosin_tail

MYH2 MYH4 MYH7 MYH8

5.62e-06181264IPR002928
DomainDUF3398

DOCK11 DOCK9 DOCK6

5.91e-0661263PF11878
DomainDOCK_C/D_N

DOCK11 DOCK9 DOCK6

5.91e-0661263IPR021816
DomainMyosin-like_IQ_dom

MYH2 MYH4 MYH7 MYH8

7.08e-06191264IPR027401
Domain-

MYH2 MYH4 MYH7 MYH8

7.08e-061912644.10.270.10
Domain-

MOSPD2 CFAP221 HYDIN

1.64e-05812632.60.40.360
DomainPapD-like

MOSPD2 CFAP221 HYDIN

2.44e-0591263IPR008962
DomainCadherin_tail

PCDHGA5 PCDHA11 PCDHA5 PCDHA4

1.10e-04371264PF15974
DomainCadherin_CBD

PCDHGA5 PCDHA11 PCDHA5 PCDHA4

1.10e-04371264IPR031904
Domain-

PAPOLB PAPOLA

1.35e-04312623.30.70.590
DomainRB_A

RBL1 RBL2

1.35e-0431262IPR002720
DomainDUF3452

RBL1 RBL2

1.35e-0431262PF11934
DomainRB_B

RBL1 RBL2

1.35e-0431262IPR002719
DomainAnion_exchange_CS

SLC4A3 SLC4A2

1.35e-0431262IPR018241
DomainCBF

NOC3L CEBPZ

1.35e-0431262PF03914
DomainRB_C

RBL1 RBL2

1.35e-0431262IPR015030
DomainRB_fam

RBL1 RBL2

1.35e-0431262IPR028309
DomainCCAAT-binding_factor

NOC3L CEBPZ

1.35e-0431262IPR005612
DomainNuclTrfase_I_C

PAPOLB PAPOLA

1.35e-0431262IPR011068
DomainRB_N

RBL1 RBL2

1.35e-0431262IPR024599
DomainPAP_central

PAPOLB PAPOLA

1.35e-0431262PF04928
DomainPAP_RNA-bind

PAPOLB PAPOLA

1.35e-0431262PF04926
DomainPolA_pol_cen_dom

PAPOLB PAPOLA

1.35e-0431262IPR007012
DomainPolA_pol_RNA-bd_dom

PAPOLB PAPOLA

1.35e-0431262IPR007010
DomainRB_A

RBL1 RBL2

1.35e-0431262PF01858
DomainRB_B

RBL1 RBL2

1.35e-0431262PF01857
DomainPolyA_polymerase

PAPOLB PAPOLA

1.35e-0431262IPR014492
DomainDUF3452

RBL1 RBL2

1.35e-0431262SM01367
DomainRb_C

RBL1 RBL2

1.35e-0431262SM01369
DomainRB_A

RBL1 RBL2

1.35e-0431262SM01368
DomainIQ

MYH2 MYH4 MYH7 MYH8 MYO15A

2.19e-04811265SM00015
DomainIQ_motif_EF-hand-BS

MYH2 MYH4 MYH7 MYH8 MYO15A

3.59e-04901265IPR000048
DomainIQ

MYH2 MYH4 MYH7 MYH8 MYO15A

4.17e-04931265PS50096
DomainAnion_exchange

SLC4A3 SLC4A2

4.46e-0451262IPR001717
DomainARM-type_fold

DOCK11 DOCK9 NOC3L ITPR2 DOCK5 NCAPG AP2B1 PIK3C2B CEBPZ

4.92e-043391269IPR016024
DomainANION_EXCHANGER_2

SLC4A3 SLC4A2

9.27e-0471262PS00220
DomainANION_EXCHANGER_1

SLC4A3 SLC4A2

9.27e-0471262PS00219
DomainCadherin_2

PCDHGA5 PCDHA11 PCDHA5 PCDHA4

9.73e-04651264PF08266
DomainCadherin_N

PCDHGA5 PCDHA11 PCDHA5 PCDHA4

9.73e-04651264IPR013164
DomainNeurexophilin

NXPE1 NXPH2

1.23e-0381262PF06312
DomainNXPH/NXPE

NXPE1 NXPH2

1.23e-0381262IPR026845
DomainIQ

MYH2 MYH4 MYH8 MYO15A

1.35e-03711264PF00612
Domain-

SLC4A3 SLC4A2

1.58e-03912623.40.1100.10
DomainBand3_cytoplasmic_dom

SLC4A3 SLC4A2

1.58e-0391262IPR013769
DomainBand_3_cyto

SLC4A3 SLC4A2

1.58e-0391262PF07565
DomainP-loop_NTPase

DDX47 DNHD1 MYH2 MYH4 ABCC4 MYH7 MYH8 KIF23 UST ARHGAP5 SLFN11 DSEL MYO15A HYDIN

1.75e-0384812614IPR027417
DomainPTrfase/Anion_transptr

SLC4A3 SLC4A2

1.96e-03101262IPR016152
DomainHCO3_transpt_euk

SLC4A3 SLC4A2

1.96e-03101262IPR003020
DomainHCO3_cotransp

SLC4A3 SLC4A2

1.96e-03101262PF00955
DomainHCO3_transpt_C

SLC4A3 SLC4A2

1.96e-03101262IPR011531
DomainNTP_transf_2

PAPOLB PAPOLA

2.39e-03111262PF01909
DomainPolymerase_NTP_transf_dom

PAPOLB PAPOLA

2.39e-03111262IPR002934
DomainWWE

TIPARP PARP12

2.85e-03121262PF02825
DomainWWE-dom

TIPARP PARP12

2.85e-03121262IPR004170
DomainWWE

TIPARP PARP12

2.85e-03121262PS50918
DomainSH3_domain

MIA3 FNBP1L DOCK5 MACF1 MYO15A ZNF582

3.81e-032201266IPR001452
DomainSialyl_trans

ST3GAL1 ST3GAL2

4.48e-03151262IPR012163
DomainOAR

ALX4 ALX1

4.48e-03151262PF03826
DomainOAR

ALX4 ALX1

5.09e-03161262PS50803
DomainOAR_dom

ALX4 ALX1

5.09e-03161262IPR003654
DomainPoly(ADP-ribose)pol_cat_dom

TIPARP PARP12

5.75e-03171262IPR012317
DomainPARP_CATALYTIC

TIPARP PARP12

5.75e-03171262PS51059
DomainPARP

TIPARP PARP12

5.75e-03171262PF00644
Domain-

TIPARP PARP12

5.75e-031712623.90.228.10
DomainCadherin_CS

PCDHGA5 PCDHA11 PCDHA5 PCDHA4

6.37e-031091264IPR020894
Pubmed

Myosin heavy chain isoforms of the murine masseter muscle during pre- and post-natal development.

MYH2 MYH4 MYH7 MYH8

9.58e-105131412919077
Pubmed

Distinct myogenic programs of embryonic and fetal mouse muscle cells: expression of the perinatal myosin heavy chain isoform in vitro.

MYH2 MYH4 MYH7 MYH8

2.87e-09613141728586
Pubmed

Spatial and temporal changes in myosin heavy chain gene expression in skeletal muscle development.

MYH2 MYH4 MYH7 MYH8

2.87e-096131410588881
Pubmed

A fast Myosin super enhancer dictates muscle fiber phenotype through competitive interactions with Myosin genes.

MYH2 MYH4 MYH7 MYH8

6.67e-097131435210422
Pubmed

Diversity in transcriptional start site selection and alternative splicing affects the 5'-UTR of mouse striated muscle myosin transcripts.

MYH2 MYH4 MYH7 MYH8

6.67e-097131416819597
Pubmed

Contractile protein gene expression in primary myotubes of embryonic mouse hindlimb muscles.

MYH2 MYH4 MYH7 MYH8

1.34e-071313148404542
Pubmed

Defective excitation-contraction coupling is partially responsible for impaired contractility in hindlimb muscles of Stac3 knockout mice.

MYH2 MYH4 MYH7 MYH8

1.87e-0714131427184118
Pubmed

Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity.

DOCK11 DOCK9 DOCK5 DOCK6

1.87e-0714131412432077
Pubmed

Slow and fast fiber isoform gene expression is systematically altered in skeletal muscle of the Sox6 mutant, p100H.

MYH2 MYH4 MYH7 MYH8

4.40e-0717131416124007
Pubmed

Developmental pattern of mouse skeletal myosin heavy chain gene transcripts in vivo and in vitro.

MYH2 MYH4 MYH8

5.19e-07513133829126
Pubmed

Sequential accumulation of mRNAs encoding different myosin heavy chain isoforms during skeletal muscle development in vivo detected with a recombinant plasmid identified as coding for an adult fast myosin heavy chain from mouse skeletal muscle.

MYH2 MYH4 MYH8

5.19e-07513136196357
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

B3GALNT1 ABCC4 MIA3 ATP6V0A1 MOSPD2 RTN3 ST3GAL1 ST3GAL2 HACD2 UST TXNDC11 SLC4A2 SACM1L ITPR2 MET POFUT1 DSEL SLC27A3

6.40e-0712011311835696571
Pubmed

Organization of human and mouse skeletal myosin heavy chain gene clusters is highly conserved.

MYH2 MYH4 MYH8

1.04e-066131310077619
Pubmed

ANKK1 is found in myogenic precursors and muscle fibers subtypes with glycolytic metabolism.

MYH2 MYH4 MYH7

1.81e-067131329758057
Pubmed

Neuromuscular junction immaturity and muscle atrophy are hallmarks of the ColQ-deficient mouse, a model of congenital myasthenic syndrome with acetylcholinesterase deficiency.

MYH2 MYH4 MYH7

2.88e-068131326993635
Pubmed

Genes for skeletal muscle myosin heavy chains are clustered and are not located on the same mouse chromosome as a cardiac myosin heavy chain gene.

MYH4 MYH7 MYH8

2.88e-06813133864153
Pubmed

GASP-2 overexpressing mice exhibit a hypermuscular phenotype with contrasting molecular effects compared to GASP-1 transgenics.

MYH2 MYH4 MYH7

4.31e-069131331960486
Pubmed

Molecular mechanisms governing Pcdh-gamma gene expression: evidence for a multiple promoter and cis-alternative splicing model.

PCDHA11 PCDHA5 PCDHA4

4.31e-069131312154121
Pubmed

The expression of myosin genes in developing skeletal muscle in the mouse embryo.

MYH4 MYH7 MYH8

6.15e-061013132211821
Pubmed

Myosin heavy chain-embryonic regulates skeletal muscle differentiation during mammalian development.

MYH2 MYH4 MYH7 MYH8

7.23e-0633131432094117
Pubmed

CAP2 deficiency delays myofibril actin cytoskeleton differentiation and disturbs skeletal muscle architecture and function.

MYH2 MYH4 MYH7

8.43e-0611131330962377
Pubmed

Deletion of the protein kinase A/protein kinase G target SMTNL1 promotes an exercise-adapted phenotype in vascular smooth muscle.

MYH2 MYH4 MYH7

8.43e-0611131318310078
Pubmed

Diversity revealed by a novel family of cadherins expressed in neurons at a synaptic complex.

PCDHA11 PCDHA5 PCDHA4

8.43e-061113139655502
Pubmed

Modulation of contractile protein gene expression in fetal murine crural muscles: emergence of muscle diversity.

MYH2 MYH4 MYH8

8.43e-061113138136524
Pubmed

Calcineurin is necessary for the maintenance but not embryonic development of slow muscle fibers.

MYH2 MYH4 MYH7

8.43e-0611131316024798
Pubmed

Ephrin-A3 promotes and maintains slow muscle fiber identity during postnatal development and reinnervation.

MYH2 MYH4 MYH7

8.43e-0611131326644518
Pubmed

The histone code reader Spin1 controls skeletal muscle development.

MYH2 MYH4 MYH7

8.43e-0611131329168801
Pubmed

Proteins of the CNR family are multiple receptors for Reelin.

PCDHA11 PCDHA5 PCDHA4

1.12e-0512131310612399
Pubmed

LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.

EXOC6 MIA3 ATP6V0A1 NOC3L RTN3 HACD2 NSUN2 SLC4A2 SACM1L YIF1A NCAPG CEBPZ POFUT1 SLC27A3

1.35e-059421311431073040
Pubmed

Regulation of spermatogenesis by testis-specific, cytoplasmic poly(A) polymerase TPAP.

PAPOLB PAPOLA

1.41e-052131212471261
Pubmed

Length-dependent effects on cardiac contractile dynamics are different in cardiac muscle containing α- or β-myosin heavy chain.

MYH4 MYH7

1.41e-052131223111184
Pubmed

Vascular endothelial growth factor upregulates expression of annexin A2 in vitro and in a mouse model of ischemic retinopathy.

ANXA2 ANXA2P2

1.41e-052131219536308
Pubmed

Annexin A2 modulates radiation-sensitive transcriptional programming and cell fate.

ANXA2 ANXA2P2

1.41e-052131223148505
Pubmed

Early expression of p107 is associated with 3T3-L1 adipocyte differentiation.

RBL1 RBL2

1.41e-052131212242027
Pubmed

ANXA2 (annexin A2) is crucial to ATG7-mediated autophagy, leading to tumor aggressiveness in triple-negative breast cancer cells.

ANXA2 ANXA2P2

1.41e-052131238290972
Pubmed

The cDNA sequence for the protein-tyrosine kinase substrate p36 (calpactin I heavy chain) reveals a multidomain protein with internal repeats.

ANXA2 ANXA2P2

1.41e-05213123013423
Pubmed

Activation of Annexin A2 signaling at the blood-brain barrier in a mouse model of multiple sclerosis.

ANXA2 ANXA2P2

1.41e-052131235064931
Pubmed

Complex Roles of Annexin A2 in Host Blood-Brain Barrier Invasion by Cryptococcus neoformans.

ANXA2 ANXA2P2

1.41e-052131228130864
Pubmed

RNA cytosine methylation by Dnmt2 and NSun2 promotes tRNA stability and protein synthesis.

NSUN2 TRDMT1

1.41e-052131222885326
Pubmed

Shared role of the pRB-related p130 and p107 proteins in limb development.

RBL1 RBL2

1.41e-05213128682294
Pubmed

Vascular ligation response is independent of p107: stressing the role of the related p130.

RBL1 RBL2

1.41e-052131212860570
Pubmed

Localization of annexin II in the paranodal regions and Schmidt-Lanterman incisures in the peripheral nervous system.

ANXA2 ANXA2P2

1.41e-052131217549680
Pubmed

Thrombin-activatable procarboxypeptidase B regulates activated complement C5a in vivo.

CPB2 C5

1.41e-052131217105819
Pubmed

Annexin A2 promotes proliferative vitreoretinopathy in response to a macrophage inflammatory signal in mice.

ANXA2 ANXA2P2

1.41e-052131239384746
Pubmed

Annexin A2 mediates up-regulation of NF-κB, β-catenin, and stem cell in response to progastrin in mice and HEK-293 cells.

ANXA2 ANXA2P2

1.41e-052131220826156
Pubmed

Prohibitin/annexin 2 interaction regulates fatty acid transport in adipose tissue.

ANXA2 ANXA2P2

1.41e-052131227468426
Pubmed

Homocysteine inhibits neoangiogenesis in mice through blockade of annexin A2-dependent fibrinolysis.

ANXA2 ANXA2P2

1.41e-052131219841537
Pubmed

In vivo expression of HGF/NK1 and GLP-1 From dsAAV vectors enhances pancreatic ß-cell proliferation and improves pathology in the db/db mouse model of diabetes.

LEPR MET

1.41e-052131220841608
Pubmed

Annexin A2 Modulates ROS and Impacts Inflammatory Response via IL-17 Signaling in Polymicrobial Sepsis Mice.

ANXA2 ANXA2P2

1.41e-052131227389701
Pubmed

Annexin II expressed by osteoblasts and endothelial cells regulates stem cell adhesion, homing, and engraftment following transplantation.

ANXA2 ANXA2P2

1.41e-052131217360942
Pubmed

Annexin A2 regulates phagocytosis of photoreceptor outer segments in the mouse retina.

ANXA2 ANXA2P2

1.41e-052131219587120
Pubmed

Loss of the mammalian DREAM complex deregulates chondrocyte proliferation.

RBL1 RBL2

1.41e-052131224710275
Pubmed

Annexin A2 at the interface between F-actin and membranes enriched in phosphatidylinositol 4,5,-bisphosphate.

ANXA2 ANXA2P2

1.41e-052131219022301
Pubmed

Primary and compensatory roles for RB family members at cell cycle gene promoters that are deacetylated and downregulated in doxorubicin-induced senescence of breast cancer cells.

RBL1 RBL2

1.41e-052131216537896
Pubmed

Multi-Omics Profiling Identifies Microglial Annexin A2 as a Key Mediator of NF-κB Pro-inflammatory Signaling in Ischemic Reperfusion Injury.

ANXA2 ANXA2P2

1.41e-052131238253182
Pubmed

Effects of bone fracture and surgery on plasma myosin heavy chain fragments of skeletal muscle.

MYH2 MYH7

1.41e-052131210579056
Pubmed

Expression of the retinoblastoma-related p107 and Rb2/p130 genes in human placenta: an immunohistochemical study.

RBL1 RBL2

1.41e-052131211642725
Pubmed

Annexin A2 is a novel cellular redox regulatory protein involved in tumorigenesis.

ANXA2 ANXA2P2

1.41e-052131222185818
Pubmed

Loss of gene function as a consequence of human papillomavirus DNA integration.

CASZ1 LIPC

1.41e-052131222262398
Pubmed

A competitive hexapeptide inhibitor of annexin A2 prevents hypoxia-induced angiogenic events.

ANXA2 ANXA2P2

1.41e-052131221486955
Pubmed

FGF signaling targets the pRb-related p107 and p130 proteins to induce chondrocyte growth arrest.

RBL1 RBL2

1.41e-052131212177046
Pubmed

Lipid raft endocytosis and exosomal transport facilitate extracellular trafficking of annexin A2.

ANXA2 ANXA2P2

1.41e-052131221737841
Pubmed

The E7 proteins of low- and high-risk human papillomaviruses share the ability to target the pRB family member p130 for degradation.

RBL1 RBL2

1.41e-052131216381817
Pubmed

Human cytomegalovirus-encoded viral cyclin-dependent kinase (v-CDK) UL97 phosphorylates and inactivates the retinoblastoma protein-related p107 and p130 proteins.

RBL1 RBL2

1.41e-052131228289097
Pubmed

Regulation of the low-dose radiation paracrine-specific anchorage-independent growth response by annexin A2.

ANXA2 ANXA2P2

1.41e-052131219580511
Pubmed

Human intestinal anion exchanger isoforms: expression, distribution, and membrane localization.

SLC4A3 SLC4A2

1.41e-052131211248201
Pubmed

Expression of p107 and p130 during human adipose-derived stem cell adipogenesis.

RBL1 RBL2

1.41e-052131218086563
Pubmed

Five skeletal myosin heavy chain genes are organized as a multigene complex in the human genome.

MYH4 MYH8

1.41e-05213128518795
Pubmed

Selenomethionine promotes ANXA2 phosphorylation for proliferation and protein synthesis of myoblasts and skeletal muscle growth.

ANXA2 ANXA2P2

1.41e-052131236739096
Pubmed

Methionine-induced hyperhomocysteinemia reverts fibrinolytic pathway activation in a murine model of acute promyelocytic leukemia.

ANXA2 ANXA2P2

1.41e-052131222517898
Pubmed

Anxa2 gene silencing attenuates obesity-induced insulin resistance by suppressing the NF-κB signaling pathway.

ANXA2 ANXA2P2

1.41e-052131230462534
Pubmed

Distinct roles for p107 and p130 in Rb-independent cellular senescence.

RBL1 RBL2

1.41e-052131218418057
Pubmed

Differential expression and functionally co-operative roles for the retinoblastoma family of proteins in epidermal differentiation.

RBL1 RBL2

1.41e-05213129747874
Pubmed

Inhibition of the membrane repair protein annexin-A2 prevents tumor invasion and metastasis.

ANXA2 ANXA2P2

1.41e-052131238092984
Pubmed

Tyrosine 23 phosphorylation-dependent cell-surface localization of annexin A2 is required for invasion and metastases of pancreatic cancer.

ANXA2 ANXA2P2

1.41e-052131221572519
Pubmed

Hypoxia-inducible factor-1 drives annexin A2 system-mediated perivascular fibrin clearance in oxygen-induced retinopathy in mice.

ANXA2 ANXA2P2

1.41e-052131221788340
Pubmed

The Membrane Phospholipid Binding Protein Annexin A2 Promotes Phagocytosis and Nonlytic Exocytosis of Cryptococcus neoformans and Impacts Survival in Fungal Infection.

ANXA2 ANXA2P2

1.41e-052131227371724
Pubmed

Overlapping and unique substrate specificities of ST3GAL1 and 2 during hematopoietic and megakaryocytic differentiation.

ST3GAL1 ST3GAL2

1.41e-052131235507766
Pubmed

Annexin A2 Deficiency Exacerbates Neuroinflammation and Long-Term Neurological Deficits after Traumatic Brain Injury in Mice.

ANXA2 ANXA2P2

1.41e-052131231817350
Pubmed

ANNEXIN A2 FACILITATES NEOVASCULARIZATION TO PROTECT AGAINST MYOCARDIAL INFARCTION INJURY VIA INTERACTING WITH MACROPHAGE YAP AND ENDOTHELIAL INTEGRIN Β3.

ANXA2 ANXA2P2

1.41e-052131237832154
Pubmed

Cell-surface translocation of annexin A2 contributes to bleomycin-induced pulmonary fibrosis by mediating inflammatory response in mice.

ANXA2 ANXA2P2

1.41e-052131230902828
Pubmed

Cell surface translocation of annexin A2 facilitates glutamate-induced extracellular proteolysis.

ANXA2 ANXA2P2

1.41e-052131224742684
Pubmed

Annexin A2 depletion exacerbates the intracerebral microhemorrhage induced by acute rickettsia and Ebola virus infections.

ANXA2 ANXA2P2

1.41e-052131232687500
Pubmed

Temporal spatial expression and function of non-muscle myosin II isoforms IIA and IIB in scar remodeling.

MYH2 MYH4

1.41e-052131221102503
Pubmed

Annexin A2 binds to endosomes following organelle destabilization by particulate wear debris.

ANXA2 ANXA2P2

1.41e-052131222453828
Pubmed

p130 is dispensable in peripheral T lymphocytes: evidence for functional compensation by p107 and pRB.

RBL1 RBL2

1.41e-05213129418868
Pubmed

Agents that bind annexin A2 suppress ocular neovascularization.

ANXA2 ANXA2P2

1.41e-052131220607799
Pubmed

A new role for host annexin A2 in establishing bacterial adhesion to vascular endothelial cells: lines of evidence from atomic force microscopy and an in vivo study.

ANXA2 ANXA2P2

1.41e-052131231253864
Pubmed

Dedicator of Cytokinesis 5 Regulates Keratinocyte Function and Promotes Diabetic Wound Healing.

LEPR DOCK5

1.41e-052131233627322
Pubmed

Annexin A2 is involved in antiphospholipid antibody-mediated pathogenic effects in vitro and in vivo.

ANXA2 ANXA2P2

1.41e-052131219628708
Pubmed

Annexin A2 binds to the localization signal in the 3' untranslated region of c-myc mRNA.

ANXA2 ANXA2P2

1.41e-052131215654879
Pubmed

cDNA cloning and tissue distribution of mRNAs for two proteins that are related to the band 3 Cl-/HCO3- exchanger.

SLC4A3 SLC4A2

1.41e-05213122294114
Pubmed

Anti-dsDNA antibodies bind to mesangial annexin II in lupus nephritis.

ANXA2 ANXA2P2

1.41e-052131220847146
Pubmed

Temporal regulation of the Mediator complex during muscle proliferation, differentiation, regeneration, aging, and disease.

MYH2 MYH4 MYH8 MED23

1.43e-0539131438690566
Pubmed

Myopathy associated LDB3 mutation causes Z-disc disassembly and protein aggregation through PKCα and TSC2-mTOR downregulation.

MYH2 MYH4 MYH7

1.84e-0514131333742095
Pubmed

Loss of Prox1 in striated muscle causes slow to fast skeletal muscle fiber conversion and dilated cardiomyopathy.

MYH2 MYH4 MYH7

1.84e-0514131324938781
Pubmed

Calcium-binding protein 7 expressed in muscle negatively regulates age-related degeneration of neuromuscular junctions in mice.

MYH2 MYH4 MYH7

1.84e-0514131338327785
Pubmed

skNAC, a Smyd1-interacting transcription factor, is involved in cardiac development and skeletal muscle growth and regeneration.

MYH2 MYH4 MYH7

1.84e-0514131321071677
Pubmed

Monoallelic yet combinatorial expression of variable exons of the protocadherin-alpha gene cluster in single neurons.

PCDHA11 PCDHA5 PCDHA4

2.30e-0515131315640798
Pubmed

Six homeoproteins and a Iinc-RNA at the fast MYH locus lock fast myofiber terminal phenotype.

MYH2 MYH4 MYH7

2.30e-0515131324852826
Cytoband1p36.22

PEX14 CASZ1 VPS13D

1.64e-043713131p36.22
Cytoband5q31

PCDHGA5 PCDHA11 PCDHA5 PCDHA4

3.43e-0411513145q31
GeneFamilyMyosin heavy chains

MYH2 MYH4 MYH7 MYH8

6.86e-07158841098
GeneFamilyClustered protocadherins

PCDHGA5 PCDHA11 PCDHA5 PCDHA4

2.66e-046488420
GeneFamilyFucosyltransferases|Blood group antigens

FUT10 POFUT1

1.76e-0313882434
CoexpressionAtlasMyeloid Cells, DC.103+11b-.PolyIC.Lu, CD45 MHCII CD11c CD103 CD11b, Lung, avg-3

TTC39B ATP6V0A1 MOSPD2 ANXA2 FNBP1L TIPARP DOCK5 MET ARHGAP5 TRIB1 PARP12

1.72e-0538412511GSM605820_500
CoexpressionAtlasMyeloid Cells, DC.103+11b-.Lv, CD45+ CD11c+ MHC-II+ CD11b low CD103+, Liver, avg-2

KIF23 MOSPD2 FNBP1L UST CDC14A TIPARP DOCK5 MET ARHGAP5 NCAPG TRIB1

3.08e-0540912511GSM538234_500
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TTC39B ABCC4 ST3GAL1 UST CASZ1 ITPR2 NXPH2

8.22e-0717313170bc2aacae60c6d3276b0949eb0748b4ac1f56e54
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TTC39B ABCC4 ST3GAL1 UST CASZ1 ITPR2 NXPH2

9.23e-071761317c2c4306476989bc2fb30dab00250ef7915842f13
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ABCC4 ARSJ FNBP1L UST CASZ1 ITPR2 NXPH2

1.43e-061881317e751cff2ac8fbc1487766c1871fcc5d1005286b0
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2-Exc_L6_FEZF2_KRT17|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ARSJ FNBP1L UST CDC14A ITPR2 GABRA5

1.20e-051721316adc09c4d1b63fe84150516beb692db1e7f7ac980
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ABCC4 ST3GAL1 UST CASZ1 ITPR2 NXPH2

1.33e-0517513161d8da48236549c01381f777ce5b2937f9f86acc2
ToppCell3'-Adult-Appendix-Epithelial-mature_enterocytic|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NOC3L KIAA1586 SACM1L FRMD4A C5 DOCK6

1.37e-05176131630adf8f1638c6244586f8101c2590bb964dfae00
ToppCell3'-Adult-Appendix-Epithelial-mature_enterocytic-Colonocyte|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NOC3L KIAA1586 SACM1L FRMD4A C5 DOCK6

1.37e-05176131623fa02d4c39e0b8faa1658116d50b6233a952ccc
ToppCelldroplet-Heart-nan-3m-Endothelial-coronary_vascular_endothelial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EXOC6 MOSPD2 FNBP1L ITPR2 ARHGAP5 PIK3C2B

1.61e-05181131692d44892bb15771f0ab5fe61879b204b0acbd9b3
ToppCell343B-Lymphocytic-CD4_T-cell-CD4+_Effector_T_cell-2|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)

PEX14 ST3GAL2 HACD2 SLC4A2 USP38 NSMAF

1.76e-0518413162c2125b8030af83f7a6d59a7102d4de8e0ac1988
ToppCellPosterior_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1-Calb1-Excitatory_Neuron.Sc17a7.Calb1-Otof_(Layer_2/3)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

MOXD2P ARSJ C12orf56 TEX29

1.80e-05531314a41f66edf468f824494a922c3addf429a9125b7f
ToppCelldroplet-Liver-LIVER_HEP-30m-Endothelial-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FUT10 DENND2D TUBGCP6 UNC5A PIK3C2B DOCK6

1.82e-051851316bdd2e6cb20294b39a9d856004bf57ba69cf877e2
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ABCC4 ARSJ UST CASZ1 ITPR2 NXPH2

1.88e-051861316a6ef5d5944af5689b5f27bef89cd05645eedbe50
ToppCelldroplet-Heart-nan-3m-Endothelial|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MOSPD2 FNBP1L ITPR2 ARHGAP5 PIK3C2B DOCK6

1.88e-0518613160ae5fbe9f210cb25092394267e1d3d6ed05627b8
ToppCellNasal_Brush-Immune-Neutrophils|Immune / Tissue, Lineage and Cell class of Lung Cells from 10X

TRPM7 RBL2 GDAP2 KIAA1586 CASZ1 CFAP221

1.88e-051861316f5aa91dbef29f7efa2b9a728c6539d7541340cd4
ToppCellCOPD-Endothelial-VE_Arterial|Endothelial / Disease state, Lineage and Cell class

EXOC6 ABCC4 LEPR TIPARP ITPR2 MET

2.18e-051911316ef16ad1c1cd2c0c0377957398c98775b62a81754
ToppCellControl-Epithelial-ATII|Epithelial / Disease state, Lineage and Cell class

ABCC4 ATP6V0A1 DOCK9 UST MACF1 TRIB1

2.38e-051941316a01de094f7bfd099bcbb2f94224690a2efb887b4
ToppCelldroplet-Lung-18m-Hematologic-myeloid-non-classical_monocyte-nonclassical_monocyte_l14|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

NOC3L DENND2D ALX4 MED23 TRIB1

2.40e-051161315f2bf9599040f43b5ea8724841d7b71c0a859c016
ToppCellLPS_only-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS_only / Treatment groups by lineage, cell group, cell type

ABCC4 ARSJ ST3GAL1 MET C5 DSEL

2.59e-0519713161a1bee8da6e04b65935c40373eaee4d6c046d9a1
ToppCellkidney_cells-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

EXOC6 ANXA2 DOCK9 GLYATL2 LEPR PIK3C2B

2.74e-051991316a3ec743b978ba8fdf1677b4971b5731f50ddd30f
ToppCellLPS_only-Epithelial_alveolar-AT_1-2_Progenitor-Progenitor_AT1-AT2|LPS_only / Treatment groups by lineage, cell group, cell type

ARSJ ANXA2 ST3GAL1 MET C5 DSEL

2.74e-0519913160447f8f53389fe7c6ddc04a97d86e74122ea16f4
DrugThioguanosine [85-31-4]; Down 200; 12.6uM; MCF7; HT_HG-U133A

RBL1 NOC3L PEX14 ST3GAL2 VPS13D NCAPG PIK3C2B TRAPPC10 TMEM63A

1.41e-0619012992619_DN
DrugPrednisolone [50-24-8]; Up 200; 11uM; MCF7; HT_HG-U133A

ATP6V0A1 DOCK9 PEX14 LEPR MET POFUT1 PARP12 TRDMT1 TMEM63A

2.06e-0619912995526_UP
Drugformycin triphosphate

MYH2 MYH4 MYH7 MYH8 MYO15A

1.03e-05511295CID000122274
DrugIproniazide phosphate [305-33-9]; Down 200; 14.4uM; MCF7; HT_HG-U133A

DOCK9 CDC14A LEPR DOCK5 MET PAPOLA POFUT1 DOCK6

1.64e-0519612982288_DN
DrugCloperastine hydrochloride [14984-68-0]; Down 200; 11uM; MCF7; HT_HG-U133A

ATP6V0A1 VPS13D LDB1 PAPOLA DOCK6 SMAD4 TRDMT1 TMEM63A

1.83e-0519912983608_DN
DrugMefenamic acid [61-68-7]; Up 200; 16.6uM; MCF7; HT_HG-U133A

ATP6V0A1 GTDC1 UST CDC14A DOCK5 MET PAPOLA POFUT1

1.83e-0519912981699_UP
DrugNystatine [1400-61-9]; Down 200; 4.4uM; MCF7; HT_HG-U133A

B3GALNT1 DOCK9 ST3GAL2 PIK3C2B POFUT1 MED23 SMAD4 TMEM63A

1.89e-0520012984807_DN
DrugPentetic acid [67-43-6]; Down 200; 10.2uM; MCF7; HT_HG-U133A

GPR85 PCDHA5 LEPR MET FRMD4A POFUT1 C5 TMEM63A

1.89e-0520012985264_DN
Drugpurealin

MYH2 MYH4 MYH7 MYH8 MYO15A

1.95e-05581295CID006419303
Diseaseautosomal dominant hyaline body myopathy (implicated_via_orthology)

MYH2 MYH4 MYH7 MYH8

6.12e-08101244DOID:0111269 (implicated_via_orthology)
Diseasedistal arthrogryposis type 2B3 (implicated_via_orthology)

MYH2 MYH4 MYH7 MYH8

6.12e-08101244DOID:0111602 (implicated_via_orthology)
Diseasedistal arthrogryposis type 1 (implicated_via_orthology)

MYH2 MYH4 MYH7 MYH8

6.12e-08101244DOID:0111596 (implicated_via_orthology)
Diseasedilated cardiomyopathy 1S (implicated_via_orthology)

MYH2 MYH4 MYH7 MYH8

6.12e-08101244DOID:0110454 (implicated_via_orthology)
Diseasecongenital myopathy 6 (implicated_via_orthology)

MYH2 MYH4 MYH7 MYH8

6.12e-08101244DOID:0080719 (implicated_via_orthology)
Diseaseinclusion body myositis (implicated_via_orthology)

MYH2 MYH4 MYH7 MYH8

6.12e-08101244DOID:3429 (implicated_via_orthology)
Diseasedistal arthrogryposis type 2A (implicated_via_orthology)

MYH2 MYH4 MYH7 MYH8

6.12e-08101244DOID:0111605 (implicated_via_orthology)
Diseasefamilial hypertrophic cardiomyopathy (implicated_via_orthology)

MYH2 MYH4 MYH7 MYH8

6.12e-08101244DOID:0080326 (implicated_via_orthology)
Diseasedistal myopathy (implicated_via_orthology)

MYH2 MYH4 MYH7 MYH8

1.43e-07121244DOID:11720 (implicated_via_orthology)
Diseasemyotonia congenita (implicated_via_orthology)

MYH2 MYH4 MYH7 MYH8

1.43e-07121244DOID:2106 (implicated_via_orthology)
Diseaserestrictive cardiomyopathy (implicated_via_orthology)

MYH2 MYH4 MYH7 MYH8

2.06e-07131244DOID:397 (implicated_via_orthology)
Diseasedistal arthrogryposis (implicated_via_orthology)

MYH2 MYH4 MYH7 MYH8

3.91e-07151244DOID:0050646 (implicated_via_orthology)
Diseasehigh density lipoprotein particle size measurement

TTC39B TULP1 LIPC NUDT3 DOCK6 TRIB1 BANK1

7.96e-061701247EFO_0008592
Diseasephospholipids in large HDL measurement

TTC39B LIPC DOCK6 TRIB1 BANK1

1.44e-05731245EFO_0022190
Diseasetotal lipids in large HDL

TTC39B LIPC DOCK6 TRIB1 BANK1

1.54e-05741245EFO_0022189
Diseasefree cholesterol in large HDL measurement

TTC39B LIPC DOCK6 TRIB1 BANK1

2.12e-05791245EFO_0022157
Diseasecholesterol in large HDL measurement

TTC39B LIPC DOCK6 TRIB1 BANK1

2.26e-05801245EFO_0021900
Diseaselipoprotein measurement, phospholipid measurement

TTC39B LEPR LIPC DOCK6 TRIB1

3.03e-05851245EFO_0004639, EFO_0004732
Diseaselipid measurement, lipoprotein measurement

TTC39B LEPR LIPC DOCK6 TRIB1

3.99e-05901245EFO_0004529, EFO_0004732
Diseasephospholipids:total lipids ratio, high density lipoprotein cholesterol measurement

TTC39B TULP1 LIPC NUDT3 MACF1 DOCK6 TRIB1 BANK1

4.86e-053071248EFO_0004612, EFO_0020946
Diseasemyopathy (implicated_via_orthology)

MYH2 MYH4 MYH7 MYH8

5.01e-05481244DOID:423 (implicated_via_orthology)
Diseasecholesteryl ester measurement, high density lipoprotein cholesterol measurement

TTC39B FNBP1L LEPR TULP1 LIPC NUDT3 DOCK6 TRIB1

5.44e-053121248EFO_0004612, EFO_0010351
Diseasetotal cholesterol measurement, high density lipoprotein cholesterol measurement

TTC39B FNBP1L LEPR TULP1 LIPC NUDT3 DOCK6 TRIB1

5.82e-053151248EFO_0004574, EFO_0004612
Diseasecholesteryl esters to total lipids in IDL percentage

LIPC MACF1 TRIB1 BANK1

5.89e-05501244EFO_0022247
Diseaselipoprotein measurement

TTC39B LEPR LIPC DOCK6 TRIB1

8.34e-051051245EFO_0004732
Diseasefree cholesterol to total lipids in very large HDL percentage

TTC39B LIPC DOCK6 TRIB1

8.58e-05551244EFO_0022288
Diseasecholesterol to total lipids in IDL percentage

LIPC MACF1 TRIB1 BANK1

1.21e-04601244EFO_0022233
Diseasesleep duration, high density lipoprotein cholesterol measurement

TTC39B LIPC MACF1 DOCK6 TRIB1

1.63e-041211245EFO_0004612, EFO_0005271
Diseasehyperinsulinism (implicated_via_orthology)

LEPR LIPC

1.74e-0451242DOID:2018 (implicated_via_orthology)
DiseaseFrontonasal dysplasia

ALX4 ALX1

1.74e-0451242C1876203
Diseasetotal lipids in very large HDL measurement

TTC39B LIPC TRIB1 BANK1

1.75e-04661244EFO_0022312
Diseasephospholipids in very large HDL measurement

TTC39B LIPC TRIB1 BANK1

1.75e-04661244EFO_0022298
Diseasecholesterol in very large HDL measurement

TTC39B LIPC TRIB1 BANK1

2.08e-04691244EFO_0022229
Diseaseesterified cholesterol measurement

TTC39B LEPR LIPC DOCK6 TRIB1

2.12e-041281245EFO_0008589
Diseasecholine measurement

TTC39B LEPR LIPC DOCK6 TRIB1

2.27e-041301245EFO_0010116
Diseasecardiomyopathy (implicated_via_orthology)

MYH2 MYH4 MYH7 MYH8

2.32e-04711244DOID:0050700 (implicated_via_orthology)
Diseasevery low density lipoprotein cholesterol measurement, phospholipids:total lipids ratio

TTC39B LEPR LIPC MACF1 DOCK6 TRIB1 BANK1

2.38e-042911247EFO_0008317, EFO_0020946
Disease1,5 anhydroglucitol measurement

PCDHA11 PCDHA5 PCDHA4

2.44e-04291243EFO_0008009
Diseasefree cholesterol:total lipids ratio, high density lipoprotein cholesterol measurement

TTC39B FNBP1L TULP1 LIPC DOCK6 TRIB1 BANK1

3.04e-043031247EFO_0004612, EFO_0020945
Diseasephospholipid measurement

TTC39B LEPR LIPC DOCK6 TRIB1

3.20e-041401245EFO_0004639
Diseasedilated cardiomyopathy (implicated_via_orthology)

MYH2 MYH4 MYH7 MYH8

3.67e-04801244DOID:12930 (implicated_via_orthology)
Diseasephospholipids:total lipids ratio

TTC39B LIPC MACF1 DOCK6 TRIB1 BANK1

4.07e-042271246EFO_0020946
Diseasefree cholesterol in small HDL measurement

LIPC DOCK6 TRIB1

4.30e-04351243EFO_0022270
Diseaselow density lipoprotein cholesterol measurement, phospholipids:total lipids ratio

EXOC6 TTC39B LIPC DOCK6 TRIB1

4.81e-041531245EFO_0004611, EFO_0020946
Diseaselow density lipoprotein cholesterol measurement, cholesteryl esters:total lipids ratio

EXOC6 TTC39B LIPC DOCK6 TRIB1

4.81e-041531245EFO_0004611, EFO_0020944
DiseaseNEPHRONOPHTHISIS 2

TTC21B NXPH2

4.82e-0481242C1865872
DiseaseCognition Disorders

ABCC4 MET SMAD4

5.49e-04381243C0009241
Diseasecholesteryl ester measurement

EXOC6 TTC39B LIPC DOCK6 TRIB1 BANK1

7.81e-042571246EFO_0010351
Disease1-stearoyl-GPE (18:0) measurement

LIPC TRIB1

9.40e-04111242EFO_0800227
Diseasecholesteryl esters:total lipids ratio, intermediate density lipoprotein measurement

LIPC MACF1 TRIB1 BANK1

9.53e-041031244EFO_0008595, EFO_0020944
Diseaseatrial fibrillation

MYH7 UST CASZ1 ITPR2 NUDT3 BANK1 SMAD4

1.00e-033711247EFO_0000275
Diseasetotal lipids in lipoprotein particles measurement

LIPC DOCK6 TRIB1

1.09e-03481243EFO_0022309
DiseaseHMG CoA reductase inhibitor use measurement

MIA3 LIPC HERC3 DOCK6 TRIB1

1.24e-031891245EFO_0009932
Diseaserenal cell carcinoma (biomarker_via_orthology)

ANXA2 ANXA2P2

1.54e-03141242DOID:4450 (biomarker_via_orthology)
Diseasetriglycerides in very large HDL measurement

TTC39B LIPC TRIB1

1.62e-03551243EFO_0022324
Diseaseglycoprotein measurement

EXOC6 LEPR TRIB1 HYDIN

1.63e-031191244EFO_0004555
Diseasetriglycerides in very large VLDL measurement

EXOC6 LIPC TRIB1

1.71e-03561243EFO_0022325
Diseasecholesterol:total lipids ratio, intermediate density lipoprotein measurement

LIPC MACF1 TRIB1 BANK1

1.73e-031211244EFO_0008595, EFO_0020943
Diseaselow density lipoprotein triglyceride measurement

LIPC TRIB1

1.77e-03151242EFO_0009946
Diseaseanemia (implicated_via_orthology)

SLC4A3 SLC4A2

1.77e-03151242DOID:2355 (implicated_via_orthology)
Diseasetotal lipids in medium HDL measurement

TTC39B LIPC DOCK6

1.89e-03581243EFO_0022310
Diseasefree cholesterol in medium HDL measurement

TTC39B LIPC DOCK6

1.89e-03581243EFO_0022267
Diseasecholesterol in medium HDL measurement

TTC39B LIPC DOCK6

1.98e-03591243EFO_0021903
Diseasephospholipids in VLDL measurement

EXOC6 LIPC TRIB1

1.98e-03591243EFO_0022301
Diseaseapolipoprotein B measurement

EXOC6 TTC39B CASZ1 LIPC NCAPG DOCK6 TRIB1 HYDIN NSMAF

1.99e-036631249EFO_0004615
Diseasepancreatic ductal carcinoma (is_marker_for)

ANXA2 MET SMAD4

2.18e-03611243DOID:3587 (is_marker_for)
Diseasefree cholesterol in VLDL measurement

EXOC6 LIPC TRIB1

2.18e-03611243EFO_0022276
Diseasefree cholesterol in HDL measurement

TTC39B LIPC DOCK6

2.18e-03611243EFO_0022264
Diseasephospholipids in HDL measurement

TTC39B LIPC DOCK6

2.18e-03611243EFO_0022293
Diseasefree cholesterol measurement, high density lipoprotein cholesterol measurement

TTC39B LEPR LIPC NUDT3 DOCK6 TRIB1

2.20e-033151246EFO_0004612, EFO_0008591
DiseaseAntibody Deficiency Syndrome

LEPR C5

2.29e-03171242C0003257
DiseaseLipidemias

LEPR LIPC

2.29e-03171242C1706412
DiseaseHyperlipidemia

LEPR LIPC

2.29e-03171242C0020473
Diseasefree cholesterol in very large HDL measurement

TTC39B LIPC TRIB1

2.29e-03621243EFO_0022273
Diseasepolyunsaturated fatty acid measurement

TTC39B LIPC DOCK6 TRIB1

2.31e-031311244EFO_0010733
Diseasetriglycerides to total lipids in IDL percentage

LIPC TRIB1 BANK1

2.39e-03631243EFO_0022329
Diseasetotal lipids in HDL measurement

TTC39B LIPC DOCK6

2.39e-03631243EFO_0022307
Diseasefatty acid measurement

EXOC6 TTC39B FNBP1L LIPC MACF1 DOCK6 TRIB1

2.51e-034361247EFO_0005110
Diseasevery low density lipoprotein cholesterol measurement, cholesterol:total lipids ratio

TTC39B MYH2 LIPC MACF1 TRIB1

2.51e-032221245EFO_0008317, EFO_0020943
Diseaseneutrophil count, basophil count

PCDHA11 PCDHA5 PCDHA4 LEPR TRIB1

2.61e-032241245EFO_0004833, EFO_0005090
Diseaselipid measurement, high density lipoprotein cholesterol measurement

TTC39B LEPR LIPC NUDT3 DOCK6 TRIB1

2.77e-033301246EFO_0004529, EFO_0004612
Diseasetotal lipids in large VLDL

EXOC6 LIPC TRIB1

2.85e-03671243EFO_0022175
Diseasephospholipids:total lipids ratio, intermediate density lipoprotein measurement

LIPC MACF1 BANK1

2.85e-03671243EFO_0008595, EFO_0020946
Diseasehydrocephalus (implicated_via_orthology)

DPCD HYDIN

2.86e-03191242DOID:10908 (implicated_via_orthology)
DiseaseDeaf Mutism

CDC14A SMAD4

3.17e-03201242C4082305
DiseaseDeafness, Acquired

CDC14A SMAD4

3.17e-03201242C0751068
DiseaseHearing Loss, Extreme

CDC14A SMAD4

3.17e-03201242C0086395
DiseaseComplete Hearing Loss

CDC14A SMAD4

3.17e-03201242C0581883
DiseaseBilateral Deafness

CDC14A SMAD4

3.17e-03201242C3665473
DiseasePrelingual Deafness

CDC14A SMAD4

3.17e-03201242C0011052
Diseasecholesterol:total lipids ratio, low density lipoprotein cholesterol measurement

TTC39B LIPC MACF1 TRIB1

3.25e-031441244EFO_0004611, EFO_0020943
Diseasecholesteryl esters to total lipids in very small VLDL percentage

LIPC TRIB1 BANK1

3.36e-03711243EFO_0022259
Diseasevery low density lipoprotein cholesterol measurement, free cholesterol:total lipids ratio

TTC39B MYH2 LIPC MACF1 TRIB1

3.45e-032391245EFO_0008317, EFO_0020945
Diseasesaturated fatty acids to total fatty acids percentage

LIPC TRIB1

3.49e-03211242EFO_0022305
Diseasefree cholesterol to total lipids in chylomicrons and extremely large VLDL percentage

LIPC TRIB1

3.49e-03211242EFO_0022277
Diseasetriglycerides to total lipids in small HDL percentage

LIPC TRIB1 BANK1

3.50e-03721243EFO_0022336
Diseasetriglycerides:total lipids ratio, low density lipoprotein cholesterol measurement

TTC39B LIPC MACF1 TRIB1

3.75e-031501244EFO_0004611, EFO_0020947
Diseasefree cholesterol to total lipids in large LDL percentage

MACF1 TRIB1 BANK1

3.78e-03741243EFO_0022280
Diseaseintellectual disability (implicated_via_orthology)

RBL1 RBL2 NSUN2

3.92e-03751243DOID:1059 (implicated_via_orthology)
DiseaseImmunologic Deficiency Syndromes

LEPR C5

4.18e-03231242C0021051

Protein segments in the cluster

PeptideGeneStartEntry
DFKVRDYPLYHLIKA

TTC21B

556

Q7Z4L5
LTSIFKHEIPYYEFQ

BANK1

311

Q8NDB2
ELEKVFQKTHYPDVY

ALX1

146

Q15699
KVFQKTHYPDVYARE

ALX4

231

Q9H161
EKLQQYYIFIPSKFK

DDX47

236

Q9H0S4
IYETFYKLVKIFQEH

SLC4A2

836

P04920
YKLYKVFTEHPLLPF

SLC4A3

841

P48751
IKVFFVKYNDPIYVK

AP2B1

321

P63010
PSKYDLENVKYLHLF

CASZ1

336

Q86V15
AYFPYFKKHNVTAVV

CDC14A

211

Q9UNH5
YIFKELQKYLPSHAV

AASDH

496

Q4L235
SVPHLQKVFDRYKSY

ANXA2

221

P07355
KKIHFLYLNVAPSRY

DNHD1

291

Q96M86
SVPHLQKVFDRYKSY

ANXA2P2

221

A6NMY6
KPFKVICIYIAFYSV

NXPH2

226

O95156
RHDVPYLFQKYVKES

RIMKLA

181

Q8IXN7
PFKLEKSVDNYYHLL

PCDHGA5

391

Q9Y5G8
IIYNLFHKTVPEFKY

TIPARP

476

Q7Z3E1
HYLYFIVLVKVKDPT

ITPR2

2591

Q14571
RDYHIFYQILSNKKP

MYH7

281

P12883
KLFEHYYQELKIVPE

NSUN2

46

Q08J23
IFDVPLYHFYKVIEV

RBL2

556

Q08999
RAHVSPLFKAKYFYI

PAXIP1

966

Q6ZW49
PSFFQKYKHYIVLLA

PAPOLB

366

Q9NRJ5
KYKRNLKAVYFVHPT

GDAP2

416

Q9NXN4
HVPFKLVSTFKNYYS

PCDHA11

391

Q9Y5I1
KHLVKDFNPYITCYI

PCGF5

6

Q86SE9
ILHKYPTVDVLRFKY

H1-8

81

Q8IZA3
ESVIKNYKRYFPVIF

MAGEA9

136

P43362
ATELYYVLKHPKEAF

LDB1

136

Q86U70
LPEFTIKHYAGKVTY

MYO15A

1696

Q9UKN7
VKKHSQFIGYPITLY

HSP90AB3P

181

Q58FF7
NLKVKHVEYDTFYIP

HERC3

601

Q15034
TKPIFLYIAYQAVHS

ARSJ

256

Q5FYB0
GVKFPPDIYYKIFTH

MFI

76

Q8NCR3
LEVYKATYHFIFAQK

KIAA1109

481

Q2LD37
KTHISYQEYPFKVFP

B3GALNT1

221

O75752
YYVKDIPATLKFFHS

HNMT

146

P50135
YHIFYQITSNKKPDL

MYH8

286

P13535
KIFIDKIYSIYHQPN

KIAA1586

441

Q9HCI6
IKVLQYHKPVQASYF

NUDT3

126

O95989
YHIFYQITSNKKPEL

MYH2

286

Q9UKX2
YYELKVVDKFHIPQE

PDE6A

526

P16499
LPIVKTEFQLLYVYH

MED23

1236

Q9ULK4
AVVYITYHNKRKIFL

KCT2

211

Q8NC54
QSPFKVYHYQFKIQF

LIPC

346

P11150
SVKKYYIHDHFIPIE

LEPR

791

P48357
FHLKRKIGYFVIQTY

GABRA5

251

P31644
KYYSHFLFKVVTKLV

TUBGCP6

1781

Q96RT7
HVPFKLVSTFKNYYS

PCDHA5

391

Q9Y5H7
YFVYLPAKLEKGIHF

TMEM63A

651

O94886
PHIYIQVKEFIYASL

EXOC6

486

Q8TAG9
PVELKALYNQYIHFK

MACF1

346

Q9UPN3
VTHYSFASFIYLKPK

OR10H4

251

Q8NGA5
EKIFHPNKGYIYVVK

PIK3C2B

1376

O00750
FVIFEKHQVYPEYVI

PARP12

661

Q9H0J9
LFEAPNFFQKYKHYI

PAPOLA

361

P51003
ETAKQVYFKRNYPHI

ABCC4

1286

O15439
FPYVALSKTYNVDKH

ALPP

96

P05187
VPKRYFSHFYIISVL

SRD5A3

71

Q9H8P0
SHVPFKLVSTFKNYY

PCDHA4

391

Q9UN74
FRHFKLYKYVFTPQV

CFAP119

206

A1A4V9
FQYDYHDKVKPRKIF

FRMD4A

241

Q9P2Q2
PYLKQHLVKTYFVIN

ADCY2

451

Q08462
YSIIIPFKNVFYHMV

HYDIN

5036

Q4G0P3
AHIQVTYVKPYFDDK

DOCK11

1831

Q5JSL3
YEKAFFTEKYLQEHP

DOCK5

1566

Q9H7D0
VVYHNKSPEFYEEFK

DOCK6

606

Q96HP0
SKYAYIQVTHVIPFF

DOCK9

1861

Q9BZ29
HKHFYVVIPQIYKQL

FNBP1L

201

Q5T0N5
KIHIGSSFEKYPLYV

CPB2

146

Q96IY4
YKLFHKPVITLFNYT

FUT10

156

Q6P4F1
YFRNYFPVKLVKTHD

DGAT2L6

81

Q6ZPD8
YFEVKEYVLPHFSVS

C5

216

P01031
YYKKFSIPDLDRHQL

DPCD

136

Q9BVM2
HSLYYSIEKPLKFFQ

HACD2

71

Q6Y1H2
TLLEFYLKTVFKNYH

IL24

111

Q13007
LVLKERALHKAPYYF

GPR173

46

Q9NS66
QVYFIKEHNVVAPYK

NSMAF

111

Q92636
VKDKTLHRAPYYFLL

GPR85

46

P60893
FYVKDPFYISLHLEI

CRIPAK

431

Q8N1N5
TYKFNFSKLIVVNYP

ETV3L

116

Q6ZN32
ILYFHENQLIYPVKK

GTDC1

86

Q4AE62
YEQLKLHITPEKFYV

SACM1L

6

Q9NTJ5
FFHNLDIDFKYIPYK

DSEL

601

Q8IZU8
QIPVDEVFFHRYYKK

CEBPZ

806

Q03701
QFFVKIVGHYASYIK

DENND2D

381

Q9H6A0
IYYFPKVVKTLKFFD

NXPE1

361

Q8N323
VPYRDSKLTHLFKNY

KIF23

386

Q02241
DPLKFYTHLYKTLFK

NOC3L

576

Q8WTT2
TNLHVSYQKYFKLEP

POFUT1

81

Q9H488
SYQKYFKLEPLQAYH

POFUT1

86

Q9H488
YKFEPKLVYHNETTV

MOXD2P

226

A6NHM9
LYKIKRYQPFSVHKS

CFAP221

581

Q4G0U5
LYKIQFHNVKPEYLD

NIPSNAP1

71

Q9BPW8
ILSKYFDLIYVHNPV

MET

826

P08581
FKVYYPKYLSKIVIF

MOSPD2

171

Q8NHP6
PIVYEKYKTQIDHYV

RTN3

991

O95197
EVYKYNFPHTQLLAK

TRDMT1

41

O14717
YFPKDLIQVVHEYTK

MIA3

96

Q5JRA6
IKEHYFKPYISKLFD

RBL1

266

P28749
YPKHKYEVLFLLGLF

SEC11B

146

P0C7V7
VHKIYPSAYIKVFDL

SMAD4

426

Q13485
QDKILIYHPAFIKYV

ST3GAL1

241

Q11201
KEKVQIYNPAFFKYI

ST3GAL2

251

Q16842
KHFQEYVKRTIPEYV

SLFN11

221

Q7Z7L1
YHIFYQILSNKKPEL

MYH4

286

Q9Y623
KFHPVNYDVFRYVIT

ARHGAP5

1376

Q13017
FGFHQLYKKYLLPLI

PEX14

121

O75381
FLPKYQKVHFKEPYS

CCDC15

631

Q0P6D6
KTVFHEEFIHYLKYV

NCAPG

41

Q9BPX3
FYFIVNKLHEYLPES

C12orf56

376

Q8IXR9
KKYVFQLTHDVYKPF

CNKSR1

466

Q969H4
PTVFVKEKHYLTAFY

PROKR1

311

Q8TCW9
YPSYFLHLDTEKKVF

TULP1

321

O00294
RFLPHYFKGVLSIYK

UST

296

Q9Y2C2
FYEPIVKKHYDNILN

TTC30B

481

Q8N4P2
YVAKKLGLLVFPYTH

YIF1A

101

O95070
KLLKYDHYLVPFTLF

TTC39B

616

Q5VTQ0
VFPIKHYQDKIRPYI

TRIB1

121

Q96RU8
YKHIFPFSLIRYDVT

SLC27A3

451

Q5K4L6
YITLFIEKLPKHRDY

STAMBP

66

O95630
YKYPFEQVVASFLRK

PRELID2

11

Q8N945
YVEVFFPQFKIEKNY

SERPINB7

271

O75635
FPKDTAYVLLYKKQH

USP38

936

Q8NB14
SKLLVSYQEIPFYHI

UNC5A

666

Q6ZN44
KYYVSKIVIHPKYQD

PRSS48

96

Q7RTY5
SRYDTKELFPKQHVY

ZNF582

81

Q96NG8
KCRKQKHFFYFPVIY

TXNDC11

171

Q6PKC3
KKLTYDYKISQHFPR

ZSWIM2

481

Q8NEG5
LFNHIYFKKPLNIYF

ATP6V0A1

556

Q93050
FYEPIVKKHYDNILN

TTC30A

481

Q86WT1
YKKAVPIYIHVFSAL

TEX29

51

Q8N6K0
ISLKPYTYEFKVENF

TRAPPC10

1041

P48553
SKKLPITRKFYAFYH

TRPM7

836

Q96QT4
ITRKFYAFYHAPIVK

TRPM7

841

Q96QT4
IYNPQAIKKVADFFY

VPS13D

636

Q5THJ4
EKYLSQKEIPFYFHV

GLYATL2

246

Q8WU03
SPYTEIHLKKYQIFS

NMI

236

Q13287