Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	IL6Ra-bind	IL13RA2 IL31RA	6.23e-04	11	64	2	PF09240
Domain	TypeI_recpt_CBD	IL13RA2 IL31RA	6.23e-04	11	64	2	IPR015321
Domain	-	IL13RA2 IL31RA LINGO1 NFATC2 SPEG LAG3 IL27RA PTK7	1.85e-03	663	64	8	2.60.40.10
Domain	Ig-like_fold	IL13RA2 IL31RA LINGO1 NFATC2 SPEG LAG3 IL27RA PTK7	2.74e-03	706	64	8	IPR013783
Domain	SH3_2	SHANK1 ARHGEF7 ARHGEF6	3.21e-03	86	64	3	IPR011511
Domain	SH3_2	SHANK1 ARHGEF7 ARHGEF6	3.21e-03	86	64	3	PF07653
Domain	Homeobox_CS	VENTX ISX DLX4 IRX2	3.80e-03	186	64	4	IPR017970
Domain	FN3	IL13RA2 IL31RA SPEG IL27RA	4.83e-03	199	64	4	PS50853
Domain	FN3_dom	IL13RA2 IL31RA SPEG IL27RA	5.73e-03	209	64	4	IPR003961
Domain	SH3	SHANK1 SH3RF1 ARHGEF7 ARHGEF6	6.43e-03	216	64	4	SM00326
Domain	SH3	SHANK1 SH3RF1 ARHGEF7 ARHGEF6	6.43e-03	216	64	4	PS50002
Domain	SH3_domain	SHANK1 SH3RF1 ARHGEF7 ARHGEF6	6.86e-03	220	64	4	IPR001452
Domain	GDS_CDC24_CS	ARHGEF7 ARHGEF6	7.89e-03	39	64	2	IPR001331
Domain	Homeobox	VENTX ISX DLX4 IRX2	8.48e-03	234	64	4	PF00046
Domain	HOMEOBOX_1	VENTX ISX DLX4 IRX2	8.73e-03	236	64	4	PS00027
Domain	HOX	VENTX ISX DLX4 IRX2	8.86e-03	237	64	4	SM00389
Domain	HOMEOBOX_2	VENTX ISX DLX4 IRX2	9.12e-03	239	64	4	PS50071
Domain	Homeobox_dom	VENTX ISX DLX4 IRX2	9.12e-03	239	64	4	IPR001356
Pathway	KEGG_MEDICUS_REFERENCE_IL6_FAMILY_TO_JAK_STAT_SIGNALING_PATHWAY	JAK2 IL13RA2 IL31RA IL27RA	2.93e-06	27	53	4	M47906
Pubmed	Mutations in a new gene encoding a protein of the hair bundle cause non-syndromic deafness at the DFNB16 locus.	STRC STRCP1	3.99e-06	2	70	2	11687802
Pubmed	Dual-vector gene therapy restores cochlear amplification and auditory sensitivity in a mouse model of DFNB16 hearing loss.	STRC STRCP1	3.99e-06	2	70	2	34910522
Pubmed	Small molecule inhibition of deubiquitinating enzyme JOSD1 as a novel targeted therapy for leukemias with mutant JAK2.	JAK2 JOSD1	3.99e-06	2	70	2	34326465
Pubmed	Transformation of hematopoietic cells and activation of JAK2-V617F by IL-27R, a component of a heterodimeric type I cytokine receptor.	JAK2 IL27RA	3.99e-06	2	70	2	18003935
Pubmed	Cochlear outer hair cell horizontal top connectors mediate mature stereocilia bundle mechanics.	STRC STRCP1	1.20e-05	3	70	2	30801007
Pubmed	Effects of interleukin-31 on MUC5AC gene expression in nasal allergic inflammation.	IL31RA MUC5AC	1.20e-05	3	70	2	23392388
Pubmed	Identification of preferred protein interactions by phage-display of the human Src homology-3 proteome.	SH3RF1 ARHGEF7 ARHGEF6	1.74e-05	25	70	3	16374509
Pubmed	Stereocilin-deficient mice reveal the origin of cochlear waveform distortions.	STRC STRCP1	2.39e-05	4	70	2	18849963
Pubmed	PAK kinases are directly coupled to the PIX family of nucleotide exchange factors.	ARHGEF7 ARHGEF6	2.39e-05	4	70	2	9659915
Pubmed	Novel regulatory mechanisms for the Dbl family guanine nucleotide exchange factor Cool-2/alpha-Pix.	ARHGEF7 ARHGEF6	2.39e-05	4	70	2	15306850
Pubmed	A tyrosine-phosphorylated protein that binds to an important regulatory region on the cool family of p21-activated kinase-binding proteins.	ARHGEF7 ARHGEF6	2.39e-05	4	70	2	10428811
Pubmed	The Cool-2/alpha-Pix protein mediates a Cdc42-Rac signaling cascade.	ARHGEF7 ARHGEF6	2.39e-05	4	70	2	15649357
Pubmed	Expanding functions of GIT Arf GTPase-activating proteins, PIX Rho guanine nucleotide exchange factors and GIT-PIX complexes.	ARHGEF7 ARHGEF6	2.39e-05	4	70	2	27182061
Pubmed	Interaction of alphaPIX (ARHGEF6) with beta-parvin (PARVB) suggests an involvement of alphaPIX in integrin-mediated signaling.	ARHGEF7 ARHGEF6	2.39e-05	4	70	2	12499396
Pubmed	The Cbl proteins are binding partners for the Cool/Pix family of p21-activated kinase-binding proteins.	ARHGEF7 ARHGEF6	2.39e-05	4	70	2	12935897
Pubmed	The Shank family of postsynaptic density proteins interacts with and promotes synaptic accumulation of the beta PIX guanine nucleotide exchange factor for Rac1 and Cdc42.	SHANK1 ARHGEF7	2.39e-05	4	70	2	12626503
Pubmed	Paxillin-dependent paxillin kinase linker and p21-activated kinase localization to focal adhesions involves a multistep activation pathway.	ARHGEF7 ARHGEF6	3.98e-05	5	70	2	12006652
Pubmed	An unusually powerful mode of low-frequency sound interference due to defective hair bundles of the auditory outer hair cells.	STRC STRCP1	3.98e-05	5	70	2	24920589
Pubmed	The p21-activated kinase PAK is negatively regulated by POPX1 and POPX2, a pair of serine/threonine phosphatases of the PP2C family.	ARHGEF7 ARHGEF6	3.98e-05	5	70	2	11864573
Pubmed	The X-linked lymphoproliferative disease gene product SAP associates with PAK-interacting exchange factor and participates in T cell activation.	ARHGEF7 ARHGEF6	8.33e-05	7	70	2	16983070
Pubmed	The GIT family of ADP-ribosylation factor GTPase-activating proteins. Functional diversity of GIT2 through alternative splicing.	ARHGEF7 ARHGEF6	8.33e-05	7	70	2	10896954
Pubmed	N-α-acetyltransferase 10 protein suppresses cancer cell metastasis by binding PIX proteins and inhibiting Cdc42/Rac1 activity.	ARHGEF7 ARHGEF6	8.33e-05	7	70	2	21295525
Pubmed	Affixin activates Rac1 via betaPIX in C2C12 myoblast.	ARHGEF7 ARHGEF6	1.11e-04	8	70	2	18325335
Pubmed	Stereocilin connects outer hair cell stereocilia to one another and to the tectorial membrane.	STRC STRCP1	1.11e-04	8	70	2	21165971
Pubmed	Gene-deficient mouse model established by CRISPR/Cas9 system reveals 15 reproductive organ-enriched genes dispensable for male fertility.	C3orf22 NT5C1B	1.78e-04	10	70	2	38835510
Pubmed	Clarin-2 is essential for hearing by maintaining stereocilia integrity and function.	STRC STRCP1	2.17e-04	11	70	2	31448880
Pubmed	Otogelin, otogelin-like, and stereocilin form links connecting outer hair cell stereocilia to each other and the tectorial membrane.	STRC STRCP1	2.17e-04	11	70	2	31776257
Pubmed	Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability.	NCAPD3 SZT2 JOSD1 CHD4	2.26e-04	147	70	4	29576527
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	JAK2 RHBDF1 SH3RF1 SZT2 KIF26A MTHFD1L SPEG POLG JOSD1	3.65e-04	1105	70	9	35748872
Pubmed	Distal airways are protected from goblet cell metaplasia by diminished expression of IL-13 signalling components.	IL13RA2 MUC5AC	4.12e-04	15	70	2	25772331
Pubmed	Identification of Novel Nuclear Factor of Activated T Cell (NFAT)-associated Proteins in T Cells.	NFATC2 MTHFD1L POLG CHD4	4.67e-04	178	70	4	27637333
Pubmed	Mammalian Otolin: a multimeric glycoprotein specific to the inner ear that interacts with otoconial matrix protein Otoconin-90 and Cerebellin-1.	STRC STRCP1	5.33e-04	17	70	2	20856818
Pubmed	Dynamic and coordinated expression profile of dbl-family guanine nucleotide exchange factors in the developing mouse brain.	ARHGEF7 ARHGEF6	5.98e-04	18	70	2	12799088
Pubmed	The nuclear import of the small GTPase Rac1 is mediated by the direct interaction with karyopherin alpha2.	ARHGEF7 ARHGEF6	5.98e-04	18	70	2	19961560
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	NCAPD3 SZT2 KIF26A ARHGEF7 DOLK JOSD1	6.93e-04	529	70	6	14621295
Pubmed	Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls.	JAK2 IL13RA2 MUC5AC IL27RA	7.79e-04	204	70	4	20503287
Pubmed	Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes.	JAK2 IL13RA2 MUC5AC IL27RA	7.93e-04	205	70	4	19258923
Pubmed	Polymorphisms in innate immunity genes and risk of childhood leukemia.	CD93 ATG9B IRAK2 CD46	8.07e-04	206	70	4	20438785
Pubmed	Risk of meningioma and common variation in genes related to innate immunity.	CD93 ATG9B IRAK2 CD46	8.22e-04	207	70	4	20406964
Pubmed	Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.	JAK2 IL13RA2 MUC5AC IL27RA	8.22e-04	207	70	4	17703412
Pubmed	Common variation in genes related to innate immunity and risk of adult glioma.	CD93 ATG9B IRAK2 CD46	8.37e-04	208	70	4	19423540
Pubmed	Biological pathway-based genome-wide association analysis identified the vasoactive intestinal peptide (VIP) pathway important for obesity.	VIPR2 NFATC2	9.83e-04	23	70	2	20379146
Pubmed	New genetic associations detected in a host response study to hepatitis B vaccine.	CD93 IL13RA2 IL31RA NFATC2 LAG3 CD46 LY75	1.34e-03	824	70	7	20237496
Pubmed	Distinct transcriptomic changes in E14.5 mouse skeletal muscle lacking RYR1 or Cav1.1 converge at E18.5.	TRPM3 IRX2	1.57e-03	29	70	2	29543863
Pubmed	The insulin receptor substrate of 53 kDa (IRSp53) limits hippocampal synaptic plasticity.	SHANK1 ARHGEF7	1.57e-03	29	70	2	19208628
Pubmed	Risk of non-Hodgkin lymphoma in association with germline variation in complement genes.	CD93 CD46	1.79e-03	31	70	2	19344414
Pubmed	Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones.	PLB1 CUBN	1.79e-03	31	70	2	15583024
Pubmed	DNA-binding specificities of human transcription factors.	VENTX IRX2	1.79e-03	31	70	2	23332764
Pubmed	High-throughput mapping of a dynamic signaling network in mammalian cells.	ARHGEF7 ARFGAP3 IRAK2 ARHGEF6	1.90e-03	260	70	4	15761153
Cytoband	15q15.3	SERINC4 STRC STRCP1	7.62e-06	25	70	3	15q15.3
Cytoband	Ensembl 112 genes in cytogenetic band chr15q15	SERINC4 STRC STRCP1	1.50e-03	147	70	3	chr15q15
Cytoband	Ensembl 112 genes in cytogenetic band chr7q36	VIPR2 ATG9B KRBA1	1.88e-03	159	70	3	chr7q36
GeneFamily	CD molecules\|I-set domain containing\|Immunoglobulin like domain containing\|Interleukin receptors\|TIR domain containing	IL13RA2 IL31RA IL27RA	2.38e-04	42	52	3	602
CoexpressionAtlas	DevelopingKidney_e15.5_Cap mesenchyme_emap-27738_k-means-cluster#3_top-relative-expression-ranked_1000	ZWILCH SZT2 DTNA MTHFD1L POLR1B LY75	2.10e-05	181	66	6	gudmap_developingKidney_e15.5_Cap mesenchyme_1000_k3
Disease	autosomal recessive nonsyndromic deafness 16 (implicated_via_orthology)	STRC STRCP1	5.23e-06	2	68	2	DOID:0110471 (implicated_via_orthology)
Disease	Pregnancy Complications	JAK2 HSD11B2	1.57e-05	3	68	2	C0032962
Disease	platelet crit	JAK2 KRBA1 KIF26A NUP210L JOSD1 POLR1B NIBAN2 CUBN LY75	3.26e-04	952	68	9	EFO_0007985
Disease	sphingomyelin 14:0 measurement	TRPM3 IRX2	6.96e-04	17	68	2	EFO_0010390
Disease	cardiomyopathy (is_implicated_in)	DTNA POLG	8.72e-04	19	68	2	DOID:0050700 (is_implicated_in)
Disease	ankylosing spondylitis (is_implicated_in)	JAK2 KDM5A	8.72e-04	19	68	2	DOID:7147 (is_implicated_in)
Disease	Hypermetropia, Myopia	VIPR2 ANTXR2 MTHFD1L CUBN	9.64e-04	189	68	4	HP_0000540, HP_0000545
Disease	colon adenocarcinoma (is_implicated_in)	JAK2 CHD4	1.64e-03	26	68	2	DOID:234 (is_implicated_in)
Disease	Nephrotic Syndrome	TNS2 HSD11B2	1.77e-03	27	68	2	C0027726

Protein segments in the cluster

Peptide	Gene	Start	Entry
CSRPWPPKPKNAITI	NT5C1B	296	Q96P26
IKPWSLSCLRPAPPL	ARHGEF6	586	Q15052
DLWLDSCVVPPLSPP	ARFGAP3	131	Q9NP61
AINLCPLPKPWKLSF	ALDOB	286	P05062
PWSIPFTLKPELLAP	GSDMC	441	Q9BYG8
PLLPSRLPKWSEGPC	CD93	151	Q9NPY3
WPLCCKVVIKDPPPP	ANTXR2	341	P58335
LEPPKTPKPWSLSCL	ARHGEF7	641	Q14155
TPKPWSLSCLRPAPP	ARHGEF7	646	Q14155
WLCQRLLPPPAALAV	HSD11B2	46	P80365
WRLHCLKLQPLSPVP	MTHFD1L	346	Q6UB35
APSPPPLCNLWELKL	C3orf22	91	Q8N5N4
PCSPPLPSLWDLPKA	DLX4	196	Q92988
VNLWPPRCLPALLVS	CDHR4	331	A6H8M9
KLEPIPEWPPLASCG	DCAF16	106	Q9NXF7
PPGCTPPALLDISWL	POLM	91	Q9NP87
LKWSIPLGPIPARCF	IL13RA2	256	Q14627
VLCILPPPHPKWGSI	ISX	226	Q2M1V0
IPWVPPECIENPKNL	JAK2	716	O60674
ILKCPTQFPLILWHP	NIBAN2	151	Q96TA1
CSIPVTASLPPLEWP	NFATC2	386	Q13469
CLKEIPVPVLRPAWP	KRBA1	506	A5PL33
WDPPVPKCLKVLPPS	CD46	276	P15529
SLPIWLIPRPCTQKG	DOLK	416	Q9UPQ8
LNWKPAPEIRCPIPA	IRAK2	91	O43187
PNKLTHLCWPTVPNP	IL31RA	546	Q8NI17
LLWPQCPLTFLLSAP	OR51J1	171	Q9H342
LLLQAQLPPKPPAWA	POLG	156	P54098
PLLLWKAPGPCVQVS	IL27RA	251	Q6UWB1
PLAEGWALPTKPRCL	PDZD3	316	Q86UT5
CSAAWKPPQLLIPPL	KCNH4	801	Q9UQ05
SPWVPCLPGKVIQIP	LMLN2	571	A0A1B0GTW7
SVKCPSPVLNTPWIP	LY75	1236	O60449
LWPPPAPPCLLRAAS	KIF26A	346	Q9ULI4
PSPLLACWQPILLLV	LINGO1	16	Q96FE5
NLPSSLCWGPLKLPL	JOSD1	121	Q15040
FLQPLWVAPVKPLQP	LAG3	11	P18627
WTLTCRPKLCPLPPA	MUC5AC	5306	P98088
TCPRLPACWLPPILT	KLLN	141	B2CW77
FCLIPPLPDVPKGDW	KDM5A	321	P29375
PPPASKPKLWSLAEI	IRX2	321	Q9BZI1
CALVWTPTLPAVPLP	MRGPRG	126	Q86SM5
WRLCGPSKPTLPLVI	CUBN	2646	O60494
LANKGLLPARCPLPW	ATG9B	371	Q674R7
DPPPQCLVWLPLLHR	DTNA	216	Q9Y4J8
WLLAKLGVQSPLPPV	ATRIP	661	Q8WXE1
LNPPLPEIPNGEWLC	CHD4	476	Q14839
PPASPCPALAFWKRV	MENT	301	Q9BUN1
QPCPLPQHNKWLIPV	NUP210L	776	Q5VU65
LIQLCQSKEWGPLPP	SZT2	956	Q5T011
KPPWLKLDIPSAVPL	RHBDF1	16	Q96CC6
PCAALVLPQTWLLLP	PRSS47P	351	A8MTI9
KEWDPNLPSLCLPNP	SCYL2	216	Q6P3W7
PPQLLFLILLSCPWI	SEZ6L2	11	Q6UXD5
LWPETLKNSPFPCNP	PLB1	36	Q6P1J6
IPGQPIPTTWPDCLL	STRC	1121	Q7RTU9
IPTTWPDCLLPLLPL	STRC	1126	Q7RTU9
WSPPVRGIPQLPCAK	SH3RF1	126	Q7Z6J0
PLPTASSLPRKLLPW	SHANK1	1826	Q9Y566
CLSLPDKPPPQPQQW	NCAPD3	1456	P42695
PAPLKNLRWKPPLVQ	CNK3/IPCEF1	301	G9CGD6
PAPLKNLRWKPPLVQ	CNKSR3	301	Q6P9H4
INLPVTALPPLWVRC	ZWILCH	126	Q9H900
QLLPAPAPEPSCLWL	SPEG	81	Q15772
LCWLPLLAGLLPPVP	SMOC2	6	Q9H3U7
IIQLPPCKTGAWIVP	TRPM3	1101	Q9HCF6
APTKALPCLPPWEGV	SPOCD1	856	Q6ZMY3
LGLLLAPLCWPPTQK	SERINC4	481	A6NH21
APLCWPPTQKPQPLI	SERINC4	486	A6NH21
CLPIPVWGLQLLLPL	TEX101	226	Q9BY14
VLPAPVPGCSLWPEK	nan	186	A8MX80
LQPPVLPSDLPSWSC	SLC35G6	241	P0C7Q6
PPALLTCWLLAPVNS	VIPR2	6	P41587
VLPAPVPGCSLWPEK	nan	156	A8MV72
VLPAPVPGCSLWPEK	nan	186	Q8N9G6
VLPAPVPGCSLWPEK	nan	186	A8MUI8
VLPAPVPGCSLWPEK	nan	186	A8MUA0
PIPTTWPDCLLPLLP	STRCP1	1126	A6NGW2
LLSPLLEKPPPSWSA	POLR1B	1076	Q9H9Y6
VTCLPPKGLPEPSVW	PTK7	341	Q13308
LALKVATPPPSAQPW	TNS2	1176	Q63HR2
LPAPVPDCSLWPEKA	nan	186	A6NL46
QLLCPWAPLSGPQAL	VENTX	181	O95231
ICLLLPESPWRNPTP	nan	61	Q96M85