Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionintracellularly cAMP-activated cation channel activity

HCN4 HCN1 HCN3 HCN2

1.37e-07101034GO:0005222
GeneOntologyMolecularFunctionintracellularly cyclic nucleotide-activated monoatomic cation channel activity

HCN4 HCN1 HCN3 HCN2

4.61e-07131034GO:0005221
GeneOntologyMolecularFunctioncyclic nucleotide-activated monoatomic ion channel activity

HCN4 HCN1 HCN3 HCN2

4.61e-07131034GO:0043855
GeneOntologyMolecularFunctionintracellularly ligand-gated monoatomic ion channel activity

HCN4 HCN1 HCN3 HCN2 RYR1

7.01e-07331035GO:0005217
GeneOntologyMolecularFunctiondisaccharide binding

LGALS9C LGALS9B LGALS9

4.60e-0671033GO:0048030
GeneOntologyMolecularFunctioncAMP binding

HCN4 HCN1 HCN3 HCN2

7.77e-06251034GO:0030552
GeneOntologyMolecularFunctionvoltage-gated sodium channel activity

HCN4 HCN1 HCN3 HCN2

9.15e-06261034GO:0005248
GeneOntologyMolecularFunctiongalactoside binding

LGALS9C LGALS9B LGALS9

1.09e-0591033GO:0016936
GeneOntologyMolecularFunction5-diphosphoinositol pentakisphosphate 1-kinase activity

PPIP5K1 PPIP5K2

2.64e-0521032GO:0033857
GeneOntologyMolecularFunctioncyclic nucleotide binding

HCN4 HCN1 HCN3 HCN2

4.78e-05391034GO:0030551
GeneOntologyMolecularFunctionoligosaccharide binding

LGALS9C LGALS9B LGALS9

1.43e-04201033GO:0070492
GeneOntologyMolecularFunctionsodium channel activity

HCN4 HCN1 HCN3 HCN2

1.49e-04521034GO:0005272
GeneOntologyMolecularFunctioninositol hexakisphosphate 3-kinase activity

PPIP5K1 PPIP5K2

1.57e-0441032GO:0052724
GeneOntologyMolecularFunctioninositol hexakisphosphate 1-kinase activity

PPIP5K1 PPIP5K2

1.57e-0441032GO:0052723
GeneOntologyMolecularFunctionpancreatic polypeptide receptor activity

NPY4R2 NPY4R

1.57e-0441032GO:0001602
GeneOntologyMolecularFunctiondiphosphoinositol pentakisphosphate kinase activity

PPIP5K1 PPIP5K2

2.61e-0451032GO:0000829
GeneOntologyMolecularFunctioninositol hexakisphosphate kinase activity

PPIP5K1 PPIP5K2

2.61e-0451032GO:0000828
GeneOntologyMolecularFunctioninositol-1,3,4,5,6-pentakisphosphate kinase activity

PPIP5K1 PPIP5K2

2.61e-0451032GO:0000827
GeneOntologyMolecularFunctioninositol hexakisphosphate 5-kinase activity

PPIP5K1 PPIP5K2

2.61e-0451032GO:0000832
GeneOntologyMolecularFunctionchannel activity

HCN4 NOX5 HCN1 HCN3 SLC26A9 AQP7P3 HCN2 RYR1 TRPV2 ATP5F1B

3.83e-0452510310GO:0015267
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

HCN4 NOX5 HCN1 HCN3 SLC26A9 AQP7P3 HCN2 RYR1 TRPV2 ATP5F1B

3.89e-0452610310GO:0022803
GeneOntologyMolecularFunctionmonoatomic cation channel activity

HCN4 NOX5 HCN1 HCN3 HCN2 RYR1 TRPV2 ATP5F1B

4.03e-043431038GO:0005261
GeneOntologyMolecularFunctionmonoatomic ion channel activity

HCN4 NOX5 HCN1 HCN3 SLC26A9 HCN2 RYR1 TRPV2 ATP5F1B

6.16e-044591039GO:0005216
GeneOntologyMolecularFunctionprotein serine/threonine kinase activator activity

LGALS9C LGALS9B ALS2 LGALS9

7.11e-04781034GO:0043539
GeneOntologyMolecularFunctionligand-gated monoatomic cation channel activity

HCN4 HCN1 HCN3 HCN2 RYR1

7.96e-041401035GO:0099094
GeneOntologyMolecularFunctionvoltage-gated monoatomic cation channel activity

HCN4 HCN1 HCN3 HCN2 RYR1

1.15e-031521035GO:0022843
GeneOntologyMolecularFunctionexonuclease activity

DCPS WRN CNOT6L CNOT1

1.32e-03921034GO:0004527
GeneOntologyMolecularFunctionU3 snoRNA binding

BMS1 TSR1

1.41e-03111032GO:0034511
GeneOntologyMolecularFunctioninositol phosphate kinase activity

PPIP5K1 PPIP5K2

1.41e-03111032GO:0180030
GeneOntologyMolecularFunctionneuropeptide Y receptor activity

NPY4R2 NPY4R

1.41e-03111032GO:0004983
GeneOntologyMolecularFunctionRNA polymerase II-specific DNA-binding transcription factor binding

HIF1A PTPRT SIRT1 IFRD1 PRKCB CNOT1 EPAS1 DNMT3A

1.43e-034171038GO:0061629
GeneOntologyMolecularFunctionRNA exonuclease activity

DCPS CNOT6L CNOT1

1.62e-03451033GO:0004532
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

HCN4 NOX5 HCN1 HCN3 SLC26A9 AQP7P3 HCN2 RYR1 SLC18A2 TRPV2 ATP5F1B

1.83e-0375810311GO:0015318
GeneOntologyMolecularFunctionvoltage-gated potassium channel activity

HCN4 HCN1 HCN3 HCN2

1.93e-031021034GO:0005249
GeneOntologyMolecularFunctionsodium ion transmembrane transporter activity

HCN4 HCN1 HCN3 HCN2 SLC18A2

1.93e-031711035GO:0015081
GeneOntologyMolecularFunctionpoly(A)-specific ribonuclease activity

CNOT6L CNOT1

1.98e-03131032GO:0004535
GeneOntologyMolecularFunctionpeptidyl-prolyl cis-trans isomerase activity

PPIL3 PIN4 NKTR

2.19e-03501033GO:0003755
GeneOntologyMolecularFunctionvoltage-gated monoatomic ion channel activity

HCN4 HCN1 HCN3 HCN2 RYR1

2.54e-031821035GO:0005244
GeneOntologyMolecularFunctioncis-trans isomerase activity

PPIL3 PIN4 NKTR

2.59e-03531033GO:0016859
GeneOntologyMolecularFunctionvoltage-gated channel activity

HCN4 HCN1 HCN3 HCN2 RYR1

2.66e-031841035GO:0022832
GeneOntologyMolecularFunctionDNA-binding transcription factor binding

HIF1A PTPRT SIRT1 IFRD1 PRKCB CNOT1 HCFC1 EPAS1 DNMT3A

3.16e-035821039GO:0140297
GeneOntologyMolecularFunctionisomerase activity

WRN PPIL3 PIN4 NKTR TMX3

3.19e-031921035GO:0016853
GeneOntologyMolecularFunctionligand-gated monoatomic ion channel activity

HCN4 HCN1 HCN3 HCN2 RYR1

3.26e-031931035GO:0015276
GeneOntologyMolecularFunctionligand-gated channel activity

HCN4 HCN1 HCN3 HCN2 RYR1

3.56e-031971035GO:0022834
GeneOntologyMolecularFunction3'-5' exonuclease activity

WRN CNOT6L CNOT1

3.86e-03611033GO:0008408
GeneOntologyMolecularFunctionpotassium channel activity

HCN4 HCN1 HCN3 HCN2

4.37e-031281034GO:0005267
GeneOntologyMolecularFunctionamide binding

NPR2 FOLH1 ITGAM FASN NPY4R NKTR

4.56e-032991036GO:0033218
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

HCN4 NOX5 HCN1 HCN3 HCN2 RYR1 SLC18A2 TRPV2 ATP5F1B

5.12e-036271039GO:0022890
GeneOntologyMolecularFunctioncarbohydrate binding

LGALS9C LGALS9B LGALS14 P4HA3 GFPT1 LGALS9

5.42e-033101036GO:0030246
GeneOntologyMolecularFunctiontranscription factor binding

HIF1A PTPRT SIRT1 IFRD1 NFATC4 PRKCB CNOT1 HCFC1 EPAS1 DNMT3A

5.51e-0375310310GO:0008134
GeneOntologyBiologicalProcessnegative regulation of natural killer cell degranulation

LGALS9C LGALS9B LGALS9

4.28e-074993GO:0043322
GeneOntologyBiologicalProcesscellular response to cGMP

NPR2 HCN4 HCN2

3.70e-067993GO:0071321
GeneOntologyBiologicalProcessregulation of natural killer cell degranulation

LGALS9C LGALS9B LGALS9

5.90e-068993GO:0043321
GeneOntologyBiologicalProcessresponse to cGMP

NPR2 HCN4 HCN2

8.82e-069993GO:0070305
GeneOntologyBiologicalProcesscellular response to organic cyclic compound

NPR2 HCN4 HCN1 HCN3 HCN2 SIRT1 RYR1 GNA14 NFATC4 GNA15 CNOT1 DNMT3A

3.29e-056059912GO:0071407
GeneOntologyBiologicalProcessnegative regulation of CD4-positive, alpha-beta T cell proliferation

LGALS9C LGALS9B LGALS9

4.68e-0515993GO:2000562
GeneOntologyBiologicalProcessnegative regulation of natural killer cell activation

LGALS9C LGALS9B LGALS9

4.68e-0515993GO:0032815
GeneOntologyBiologicalProcessresponse to organophosphorus

NPR2 HCN4 HCN1 HCN3 HCN2 RYR1

6.34e-05142996GO:0046683
GeneOntologyBiologicalProcessnegative regulation of exocytosis

LGALS9C LGALS9B ATP9A LGALS9

6.40e-0545994GO:0045920
GeneOntologyBiologicalProcessnegative regulation of leukocyte degranulation

LGALS9C LGALS9B LGALS9

6.95e-0517993GO:0043301
GeneOntologyBiologicalProcesspositive regulation of oxidoreductase activity

LGALS9C HIF1A LGALS9B LGALS9

6.98e-0546994GO:0051353
GeneOntologyBiologicalProcessnatural killer cell degranulation

LGALS9C LGALS9B LGALS9

8.31e-0518993GO:0043320
GeneOntologyBiologicalProcessnegative regulation of alpha-beta T cell proliferation

LGALS9C LGALS9B LGALS9

9.83e-0519993GO:0046642
GeneOntologyBiologicalProcesspositive regulation of defense response to bacterium

LGALS9C LGALS9B LGALS9

9.83e-0519993GO:1900426
GeneOntologyBiologicalProcessregulation of T cell chemotaxis

LGALS9C LGALS9B LGALS9

1.15e-0420993GO:0010819
GeneOntologyBiologicalProcesscellular response to cAMP

HCN4 HCN1 HCN3 HCN2

1.22e-0453994GO:0071320
GeneOntologyBiologicalProcessregulation of natural killer cell differentiation

LGALS9C LGALS9B LGALS9

1.34e-0421993GO:0032823
GeneOntologyBiologicalProcessresponse to organic cyclic compound

NPR2 HCN4 HCN1 HCN3 HCN2 ITGAM SIRT1 RYR1 GNA14 NFATC4 PRKCB GNA15 CNOT1 SDK1 DNMT3A

1.38e-0410489915GO:0014070
GeneOntologyBiologicalProcessresponse to purine-containing compound

NPR2 HCN4 HCN1 HCN3 HCN2 RYR1

1.50e-04166996GO:0014074
GeneOntologyBiologicalProcessleukocyte degranulation

LGALS9C LGALS9B ITGAM LGALS9 SLC18A2

1.73e-04108995GO:0043299
GeneOntologyBiologicalProcessregulation of membrane depolarization

HCN4 HCN1 HCN3 HCN2

2.11e-0461994GO:0003254
GeneOntologyBiologicalProcessregulation of leukocyte degranulation

LGALS9C LGALS9B ITGAM LGALS9

2.39e-0463994GO:0043300
GeneOntologyBiologicalProcessregulation of defense response to bacterium

LGALS9C LGALS9B LGALS9

2.57e-0426993GO:1900424
GeneOntologyBiologicalProcessnuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

DCPS IGF2BP1 CNOT6L CNOT1

2.70e-0465994GO:0000288
GeneOntologyBiologicalProcessregulation of CD4-positive, alpha-beta T cell proliferation

LGALS9C LGALS9B LGALS9

3.22e-0428993GO:2000561
GeneOntologyBiologicalProcessmicroglia development

ITGAM TSPAN2

3.38e-046992GO:0014005
GeneOntologyBiologicalProcesspositive regulation of cytoplasmic mRNA processing body assembly

CNOT6L CNOT1

3.38e-046992GO:0010606
GeneOntologyBiologicalProcessnegative regulation of reactive oxygen species biosynthetic process

HIF1A SIRT1 SLC18A2

3.58e-0429993GO:1903427
GeneOntologyBiologicalProcessCD4-positive, alpha-beta T cell proliferation

LGALS9C LGALS9B LGALS9

3.96e-0430993GO:0035739
GeneOntologyBiologicalProcessaction potential

NPR2 HCN4 HCN1 HCN2 GNA14 GNA15

4.20e-04201996GO:0001508
GeneOntologyBiologicalProcessregulation of lymphocyte chemotaxis

LGALS9C LGALS9B LGALS9

4.37e-0431993GO:1901623
GeneOntologyBiologicalProcesspositive regulation of regulatory T cell differentiation

LGALS9C LGALS9B LGALS9

4.37e-0431993GO:0045591
GeneOntologyBiologicalProcessmyoblast fate commitment

IFRD1 EPAS1

4.71e-047992GO:0048625
GeneOntologyBiologicalProcessnegative regulation of regulated secretory pathway

LGALS9C LGALS9B LGALS9

4.81e-0432993GO:1903306
GeneOntologyBiologicalProcessT cell chemotaxis

LGALS9C LGALS9B LGALS9

5.27e-0433993GO:0010818
GeneOntologyBiologicalProcessnegative regulation of secretion by cell

LGALS9C LGALS9B ATP9A SIRT1 LGALS9 NEO1

5.84e-04214996GO:1903531
GeneOntologyBiologicalProcessregulation of cytoplasmic mRNA processing body assembly

CNOT6L CNOT1

6.27e-048992GO:0010603
GeneOntologyBiologicalProcessregulation of Rac protein signal transduction

RASGRF1 ALS2 TNS3

6.28e-0435993GO:0035020
GeneOntologyCellularComponentHCN channel complex

HCN4 HCN1 HCN3 HCN2

5.34e-1041024GO:0098855
GeneOntologyCellularComponentdistal axon

RASGRF1 HCN4 HCN1 HCN3 ALS2 SIRT1 IGF2BP1 NEO1 SLC18A2 TRPV2 PRKCB

9.09e-0643510211GO:0150034
GeneOntologyCellularComponentaxon

HIF1A RASGRF1 HCN4 HCN1 KIF1B HCN3 ALS2 HCN2 SIRT1 IGF2BP1 NEO1 SLC18A2 TRPV2 PRKCB HCFC1

2.70e-0589110215GO:0030424
MousePhenoenhanced humoral immune response

LGALS9C LGALS9B LGALS9 MGAT5B

2.85e-0617854MP:0020155
MousePhenoincreased T-helper 1 cell number

LGALS9C LGALS9B LGALS9 NUP210

4.60e-0619854MP:0008086
MousePhenoabnormal T-helper 1 cell number

LGALS9C LGALS9B LGALS9 NUP210

1.23e-0524854MP:0008085
MousePhenopulmonary artery hypoplasia

TBC1D32 DNAH5 EPAS1

3.46e-0511853MP:0010460
DomainIon_trans_N

HCN4 HCN1 HCN3 HCN2

8.38e-1041024IPR013621
DomainIon_trans_N

HCN4 HCN1 HCN3 HCN2

8.38e-1041024PF08412
DomainK_chnl_volt-dep_EAG/ELK/ERG

HCN4 HCN1 HCN3 HCN2

8.05e-07141024IPR003938
DomainGalectin_CRD

LGALS9C LGALS9B LGALS14 LGALS9

1.09e-06151024IPR001079
DomainGal-bind_lectin

LGALS9C LGALS9B LGALS14 LGALS9

1.09e-06151024PF00337
DomainGal-bind_lectin

LGALS9C LGALS9B LGALS14 LGALS9

1.09e-06151024SM00908
DomainGALECTIN

LGALS9C LGALS9B LGALS14 LGALS9

1.09e-06151024PS51304
DomainGLECT

LGALS9C LGALS9B LGALS14 LGALS9

1.09e-06151024SM00276
Domain-

LGALS9C LGALS9B LGALS14 ADGRV1 LGALS9 EGFLAM

1.34e-059510262.60.120.200
DomainConA-like_dom

LGALS9C LGALS9B LGALS14 ADGRV1 PTPRT RYR1 LGALS9 EGFLAM

2.68e-052191028IPR013320
DomainCNMP_BINDING_1

HCN4 HCN1 HCN3 HCN2

2.68e-05321024PS00888
DomainCNMP_BINDING_2

HCN4 HCN1 HCN3 HCN2

2.68e-05321024PS00889
DomainAARP2CN

BMS1 TSR1

2.95e-0521022SM00785
DomainHIF-1a_CTAD

HIF1A EPAS1

2.95e-0521022PF08778
DomainG_Bms1/Tsr1_dom

BMS1 TSR1

2.95e-0521022IPR030387
DomainAARP2CN

BMS1 TSR1

2.95e-0521022IPR012948
DomainAARP2CN

BMS1 TSR1

2.95e-0521022PF08142
DomainHIF-1_TAD_C

HIF1A EPAS1

2.95e-0521022IPR014887
DomainBMS1_TSR1_C

BMS1 TSR1

2.95e-0521022IPR007034
DomainRIBIOP_C

BMS1 TSR1

2.95e-0521022PF04950
DomainNPY4_rcpt

NPY4R2 NPY4R

2.95e-0521022IPR001933
DomainDUF663

BMS1 TSR1

2.95e-0521022SM01362
DomainG_BMS1

BMS1 TSR1

2.95e-0521022PS51714
DomaincNMP

HCN4 HCN1 HCN3 HCN2

3.43e-05341024SM00100
DomaincNMP_binding

HCN4 HCN1 HCN3 HCN2

3.43e-05341024PF00027
DomainIon_trans_dom

HCN4 HCN1 HCN3 HCN2 RYR1 TRPV2

3.79e-051141026IPR005821
DomainIon_trans

HCN4 HCN1 HCN3 HCN2 RYR1 TRPV2

3.79e-051141026PF00520
DomaincNMP-bd_dom

HCN4 HCN1 HCN3 HCN2

3.85e-05351024IPR000595
DomainCNMP_BINDING_3

HCN4 HCN1 HCN3 HCN2

3.85e-05351024PS50042
DomaincNMP-bd-like

HCN4 HCN1 HCN3 HCN2

5.37e-05381024IPR018490
DomaincNMP-bd_CS

HCN4 HCN1 HCN2

8.41e-05161023IPR018488
DomainHIF_alpha_subunit

HIF1A EPAS1

8.83e-0531022IPR021537
DomainHIF-1

HIF1A EPAS1

8.83e-0531022PF11413
DomainFN3

IL12RB2 IL22RA1 PTPRT NEO1 EGFLAM SDK1 HCFC1

1.10e-041991027PS50853
Domain-

HCN4 HCN1 HCN3 HCN2

1.36e-044810242.60.120.10
DomainFN3_dom

IL12RB2 IL22RA1 PTPRT NEO1 EGFLAM SDK1 HCFC1

1.49e-042091027IPR003961
DomainRmlC-like_jellyroll

HCN4 HCN1 HCN3 HCN2

1.72e-04511024IPR014710
DomainGprotein_alpha_Q

GNA14 GNA15

1.76e-0441022IPR000654
DomainAcid_Pase_AS

PPIP5K1 PPIP5K2

4.37e-0461022IPR033379
DomainFN3

IL12RB2 PTPRT NEO1 EGFLAM SDK1 HCFC1

5.34e-041851026SM00060
DomainHIS_ACID_PHOSPHAT_2

PPIP5K1 PPIP5K2

6.09e-0471022PS00778
DomainHIS_ACID_PHOSPHAT_1

PPIP5K1 PPIP5K2

6.09e-0471022PS00616
DomainHis_Pase_clade-2

PPIP5K1 PPIP5K2

8.09e-0481022IPR000560
DomainHis_Phos_2

PPIP5K1 PPIP5K2

8.09e-0481022PF00328
DomainNPY_rcpt

NPY4R2 NPY4R

1.04e-0391022IPR000611
Domainfn3

IL12RB2 PTPRT NEO1 EGFLAM SDK1

1.95e-031621025PF00041
DomainGproteinA_insert

GNA14 GNA15

3.37e-03161022IPR011025
Domain-

GNA14 GNA15

3.37e-031610221.10.400.10
DomainG-alpha

GNA14 GNA15

3.37e-03161022PF00503
DomainG_alpha

GNA14 GNA15

3.37e-03161022SM00275
DomainGprotein_alpha_su

GNA14 GNA15

3.81e-03171022IPR001019
DomainCyclophilin-type_PPIase_CS

PPIL3 NKTR

4.75e-03191022IPR020892
Domain-

PPIP5K1 PPIP5K2

5.26e-032010223.40.50.1240
DomainHis_PPase_superfam

PPIP5K1 PPIP5K2

5.26e-03201022IPR029033
Pubmed

Functional expression of the human HCN3 channel.

HCN4 HCN1 HCN3 HCN2

7.25e-114103416043489
Pubmed

Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to eag and cyclic nucleotide-gated channels.

HCN4 HCN1 HCN3 HCN2

7.25e-11410349405696
Pubmed

Role of subunit heteromerization and N-linked glycosylation in the formation of functional hyperpolarization-activated cyclic nucleotide-gated channels.

HCN4 HCN1 HCN3 HCN2

7.25e-114103412928435
Pubmed

Hyperpolarization-activated and cyclic nucleotide-gated channels are differentially expressed in juxtaglomerular cells in the olfactory bulb of mice.

HCN4 HCN1 HCN3 HCN2

7.25e-114103420140458
Pubmed

Investigation of hyperpolarization-activated cyclic nucleotide-gated channels in interstitial cells of Cajal of human bladder.

HCN4 HCN1 HCN3 HCN2

7.25e-114103422748890
Pubmed

Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain.

HCN4 HCN1 HCN3 HCN2

7.25e-11410349630217
Pubmed

Genetic analysis of hyperpolarization-activated cyclic nucleotide-gated cation channels in sudden unexpected death in epilepsy cases.

HCN4 HCN1 HCN3 HCN2

7.25e-114103421615589
Pubmed

Regulation of HCN channel surface expression by a novel C-terminal protein-protein interaction.

HCN4 HCN1 HCN3 HCN2

3.62e-105103415564593
Pubmed

Developmental HCN channelopathy results in decreased neural progenitor proliferation and microcephaly in mice.

HCN4 HCN1 HCN3 HCN2

3.62e-105103434429357
Pubmed

The glucose transporter 2 regulates CD8+ T cell function via environment sensing.

LGALS9C HIF1A LGALS9B LGALS9

3.62e-105103437884694
Pubmed

BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.

MPDU1 WRN BMS1 LGALS9 RABL6 FARSA IGF2BP1 FASN TSR1 DNAJC11 HPF1 PRKCB NKTR PPIP5K2 PCCB RPL3 HCFC1 PHIP RPL9 ATP5F1B

1.67e-0913181032030463901
Pubmed

Non-CpG methylation by DNMT3B facilitates REST binding and gene silencing in developing mouse hearts.

HCN4 HCN3 HCN2 DNMT3A

2.52e-097103427956497
Pubmed

Transcription profiling of HCN-channel isotypes throughout mouse cardiac development.

HCN4 HCN1 HCN3 HCN2

2.52e-097103419421833
Pubmed

Cyclic-Nucleotide- and HCN-Channel-Mediated Phototransduction in Intrinsically Photosensitive Retinal Ganglion Cells.

HCN4 HCN1 HCN2 GNA14 GNA15

4.05e-0921103530270038
Pubmed

Crosstalk between histone modification and DNA methylation orchestrates the epigenetic regulation of the costimulatory factors, Tim‑3 and galectin‑9, in cervical cancer.

LGALS9C LGALS9B LGALS9 DNMT3A

5.03e-098103431661141
Pubmed

International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels.

HCN4 HCN1 HCN3 HCN2

1.50e-0810103416382102
Pubmed

AMPK, a Regulator of Metabolism and Autophagy, Is Activated by Lysosomal Damage via a Novel Galectin-Directed Ubiquitin Signal Transduction System.

LGALS9C LGALS9B MPDU1 LGALS9 FARSA IGF2BP1 FASN PCCB RPL3 CNOT1 RPL9 ATP5F1B

2.24e-084841031231995728
Pubmed

Galectin-9 is a high affinity IgE-binding lectin with anti-allergic effect by blocking IgE-antigen complex formation.

LGALS9C LGALS9B LGALS9

2.52e-083103319776007
Pubmed

Galectin-9 regulates follicular helper T cells to inhibit humoral autoimmunity-induced pulmonary fibrosis.

LGALS9C LGALS9B LGALS9

2.52e-083103333316546
Pubmed

Identification and characterization of galectin-9, a novel beta-galactoside-binding mammalian lectin.

LGALS9C LGALS9B LGALS9

2.52e-08310339038233
Pubmed

Ventricular HCN channels decrease the repolarization reserve in the hypertrophic heart.

HCN4 HCN1 HCN2

2.52e-083103322652004
Pubmed

Protective effect of Galectin-9 in murine model of lung emphysema: Involvement of neutrophil migration and MMP-9 production.

LGALS9C LGALS9B LGALS9

2.52e-083103328704475
Pubmed

Galectin-9 protein is up-regulated in astrocytes by tumor necrosis factor and promotes encephalitogenic T-cell apoptosis.

LGALS9C LGALS9B LGALS9

2.52e-083103323836896
Pubmed

Cytoplasmic cAMP-sensing domain of hyperpolarization-activated cation (HCN) channels uses two structurally distinct mechanisms to regulate voltage gating.

HCN4 HCN1 HCN2

2.52e-083103321187420
Pubmed

Sequence and mapping of galectin-5, a beta-galactoside-binding lectin, found in rat erythrocytes.

LGALS9C LGALS9B LGALS9

2.52e-08310337890611
Pubmed

Galectin-9 suppresses Th17 cell development in an IL-2-dependent but Tim-3-independent manner.

LGALS9C LGALS9B LGALS9

2.52e-083103322341088
Pubmed

Galectin-9 Is a Novel Regulator of Epithelial Restitution.

LGALS9C LGALS9B LGALS9

2.52e-083103332380082
Pubmed

Galectin-9-mediated protection from allo-specific T cells as a mechanism of immune privilege of corneal allografts.

LGALS9C LGALS9B LGALS9

2.52e-083103323667648
Pubmed

Novel insights into the distribution of cardiac HCN channels: an expression study in the mouse heart.

HCN4 HCN1 HCN2

2.52e-083103321945247
Pubmed

Regulatory T Cell-Mediated Suppression of Inflammation Induced by DR3 Signaling Is Dependent on Galectin-9.

LGALS9C LGALS9B LGALS9

2.52e-083103328877989
Pubmed

Galectin-9 ameliorates immune complex-induced arthritis by regulating Fc gamma R expression on macrophages.

LGALS9C LGALS9B LGALS9

2.52e-083103319800850
Pubmed

Tetramerization dynamics of C-terminal domain underlies isoform-specific cAMP gating in hyperpolarization-activated cyclic nucleotide-gated channels.

HCN4 HCN1 HCN2

2.52e-083103322006928
Pubmed

The effect of Toxoplasma gondii infection on galectin-9 expression in decidual macrophages contributing to dysfunction of decidual NK cells during pregnancy.

LGALS9C LGALS9B LGALS9

2.52e-083103338987795
Pubmed

Oncogenic miR-93-5p/Gal-9 axis drives CD8 (+) T-cell inactivation and is a therapeutic target for hepatocellular carcinoma immunotherapy.

LGALS9C LGALS9B LGALS9

2.52e-083103337105392
Pubmed

Differential roles of Sirt1 in HIF-1α and HIF-2α mediated hypoxic responses.

HIF1A SIRT1 EPAS1

2.52e-083103324423936
Pubmed

Galectin-9/Tim-3 pathway mediates dopaminergic neurodegeneration in MPTP-induced mouse model of Parkinson's disease.

LGALS9C LGALS9B LGALS9

2.52e-083103336479526
Pubmed

Profiling Lgals9 splice variant expression at the fetal-maternal interface: implications in normal and pathological human pregnancy.

LGALS9C LGALS9B LGALS9

2.52e-083103323242525
Pubmed

Galectin-9 in allergic airway inflammation and hyper-responsiveness in mice.

LGALS9C LGALS9B LGALS9

2.52e-083103319851072
Pubmed

The Role of Galectin-9 as Mediator of Atopic Dermatitis: Effect on Keratinocytes.

LGALS9C LGALS9B LGALS9

2.52e-083103333923930
Pubmed

Intracellular Galectin-9 Enhances Proximal TCR Signaling and Potentiates Autoimmune Diseases.

LGALS9C LGALS9B LGALS9

2.52e-083103331969388
Pubmed

Obesity-induced galectin-9 is a therapeutic target in B-cell acute lymphoblastic leukemia.

LGALS9C LGALS9B LGALS9

2.52e-083103335241678
Pubmed

Possible regulatory role of galectin-9 on Ascaris suum-induced eosinophilic lung inflammation in mice.

LGALS9C LGALS9B LGALS9

2.52e-083103322627368
Pubmed

Galectin-9 is required for endometrial regenerative cells to induce long-term cardiac allograft survival in mice.

LGALS9C LGALS9B LGALS9

2.52e-083103333153471
Pubmed

T cell immunoglobulin and mucin protein-3 (Tim-3)/Galectin-9 interaction regulates influenza A virus-specific humoral and CD8 T-cell responses.

LGALS9C LGALS9B LGALS9

2.52e-083103322052881
Pubmed

Galectin-9 supports primary T cell transendothelial migration in a glycan and integrin dependent manner.

LGALS9C LGALS9B LGALS9

2.52e-083103335643073
Pubmed

Galectin-9 functionally impairs natural killer cells in humans and mice.

LGALS9C LGALS9B LGALS9

2.52e-083103323408620
Pubmed

Galectin-9 Is Critical for Mucosal Adaptive Immunity through the T Helper 17-IgA Axis.

LGALS9C LGALS9B LGALS9

2.52e-083103329458010
Pubmed

Cooperative Interactions of Oligosaccharide and Peptide Moieties of a Glycopeptide Derived from IgE with Galectin-9.

LGALS9C LGALS9B LGALS9

2.52e-083103326582205
Pubmed

Developmental regulation, expression, and apoptotic potential of galectin-9, a beta-galactoside binding lectin.

LGALS9C LGALS9B LGALS9

2.52e-08310339153289
Pubmed

HCN channels in the mammalian cochlea: Expression pattern, subcellular location, and age-dependent changes.

HCN4 HCN1 HCN2

2.52e-083103333181864
Pubmed

Galectin-9 expands unique macrophages exhibiting plasmacytoid dendritic cell-like phenotypes that activate NK cells in tumor-bearing mice.

LGALS9C LGALS9B LGALS9

2.52e-083103318974023
Pubmed

Cell surface galectin-9 expressing Th cells regulate Th17 and Foxp3+ Treg development by galectin-9 secretion.

LGALS9C LGALS9B LGALS9

2.52e-083103323144904
Pubmed

Impaired Gal-9 Dysregulates the PBMC-Induced Th1/Th2 Imbalance in Abortion-Prone Matings.

LGALS9C LGALS9B LGALS9

2.52e-083103329651447
Pubmed

The N- and C-terminal carbohydrate recognition domains of galectin-9 contribute differently to its multiple functions in innate immunity and adaptive immunity.

LGALS9C LGALS9B LGALS9

2.52e-083103321146220
Pubmed

Regulation of M1‑type and M2‑type macrophage polarization in RAW264.7 cells by Galectin‑9.

LGALS9C LGALS9B LGALS9

2.52e-083103328990062
Pubmed

Galectin-9 suppresses tumor metastasis by blocking adhesion to endothelium and extracellular matrices.

LGALS9C LGALS9B LGALS9

2.52e-083103318579572
Pubmed

Crystal structure of the galectin-9 N-terminal carbohydrate recognition domain from Mus musculus reveals the basic mechanism of carbohydrate recognition.

LGALS9C LGALS9B LGALS9

2.52e-083103316990264
Pubmed

Structural analysis of the human galectin-9 N-terminal carbohydrate recognition domain reveals unexpected properties that differ from the mouse orthologue.

LGALS9C LGALS9B LGALS9

2.52e-083103318005988
Pubmed

Galectin-9 ameliorates clinical severity of MRL/lpr lupus-prone mice by inducing plasma cell apoptosis independently of Tim-3.

LGALS9C LGALS9B LGALS9

2.52e-083103323585851
Pubmed

Galectin-9 ameliorates anti-GBM glomerulonephritis by inhibiting Th1 and Th17 immune responses in mice.

LGALS9C LGALS9B LGALS9

2.52e-083103324477688
Pubmed

A unique role for galectin-9 in angiogenesis and inflammatory arthritis.

LGALS9C LGALS9B LGALS9

2.52e-083103329433546
Pubmed

Alarmin function of galectin-9 in murine respiratory tularemia.

LGALS9C LGALS9B LGALS9

2.52e-083103325898318
Pubmed

Amelioration of bleomycin-induced pulmonary fibrosis via TGF-β-induced Smad and non-Smad signaling pathways in galectin-9-deficient mice and fibroblast cells.

LGALS9C LGALS9B LGALS9

2.52e-083103331937306
Pubmed

Intestinal epithelial cells express galectin-9 in patients with food allergy that plays a critical role in sustaining allergic status in mouse intestine.

LGALS9C LGALS9B LGALS9

2.52e-083103321426359
Pubmed

Galectin-9 suppresses the generation of Th17, promotes the induction of regulatory T cells, and regulates experimental autoimmune arthritis.

LGALS9C LGALS9B LGALS9

2.52e-083103318282810
Pubmed

Galectin-9 is a suppressor of T and B cells and predicts the immune modulatory potential of mesenchymal stromal cell preparations.

LGALS9C LGALS9B LGALS9

2.52e-083103324083426
Pubmed

Galectin-9 in synergy with NF-κB inhibition restores immune regulatory capability in dendritic cells of subjects with food allergy.

LGALS9C LGALS9B LGALS9

2.52e-083103337279535
Pubmed

The protective function of galectin-9 in liver ischemia and reperfusion injury in mice.

LGALS9C LGALS9B LGALS9

2.52e-083103325931247
Pubmed

Galectin-9 protects mice from the Shwartzman reaction by attracting prostaglandin E2-producing polymorphonuclear leukocytes.

LGALS9C LGALS9B LGALS9

2.52e-083103317560833
Pubmed

A family of hyperpolarization-activated mammalian cation channels.

HCN1 HCN3 HCN2

2.52e-08310339634236
Pubmed

Pacsin 2 is required for the maintenance of a normal cardiac function in the developing mouse heart.

HCN4 HCN1 HCN3 HCN2

7.10e-0814103429107716
Pubmed

SARS-Cov-2 spike induces intestinal barrier dysfunction through the interaction between CEACAM5 and Galectin-9.

LGALS9C LGALS9B LGALS9

1.01e-074103338686388
Pubmed

Contrasting acute graft-versus-host disease effects of Tim-3/galectin-9 pathway blockade dependent upon the presence of donor regulatory T cells.

LGALS9C LGALS9B LGALS9

1.01e-074103322677125
Pubmed

Role of Tim-3/galectin-9 inhibitory interaction in viral-induced immunopathology: shifting the balance toward regulators.

LGALS9C LGALS9B LGALS9

1.01e-074103319234217
Pubmed

Tim-3/Galectin-9 signaling pathway is involved in the cytokine changes in mice with alveolar echinococcosis.

LGALS9C LGALS9B LGALS9

1.01e-074103335715604
Pubmed

Galectin-9 increases Tim-3+ dendritic cells and CD8+ T cells and enhances antitumor immunity via galectin-9-Tim-3 interactions.

LGALS9C LGALS9B LGALS9

1.01e-074103319017954
Pubmed

Galectin-9: A novel promoter of atherosclerosis progression.

LGALS9C LGALS9B LGALS9

1.01e-074103336459823
Pubmed

Galectin-9 inhibits TLR7-mediated autoimmunity in murine lupus models.

LGALS9C LGALS9B LGALS9

1.01e-074103329611821
Pubmed

Lgals9 deficiency ameliorates obesity by modulating redox state of PRDX2.

LGALS9C LGALS9B LGALS9

1.01e-074103333727589
Pubmed

The Galectin-9/Tim-3 pathway is involved in the regulation of NK cell function at the maternal-fetal interface in early pregnancy.

LGALS9C LGALS9B LGALS9

1.01e-074103325578313
Pubmed

[Expression and significance of galectin-3 and galectin-9 in mice nasal mucosa with allergic rhinitis].

LGALS9C LGALS9B LGALS9

1.01e-074103318826117
Pubmed

The expression of Galectin-9 correlates with mTOR and AMPK in murine colony-forming erythroid progenitors.

LGALS9C LGALS9B LGALS9

1.01e-074103338853593
Pubmed

[Expression of Galectin-9 and Tim-3 in lungs of mice with asthma].

LGALS9C LGALS9B LGALS9

1.01e-074103321575348
Pubmed

Activation of Tim-3-Galectin-9 pathway improves survival of fully allogeneic skin grafts.

LGALS9C LGALS9B LGALS9

1.01e-074103318346632
Pubmed

Attenuation of Th1 response through galectin-9 and T-cell Ig mucin 3 interaction inhibits autoimmune diabetes in NOD mice.

LGALS9C LGALS9B LGALS9

1.01e-074103319670381
Pubmed

Recipient T cell TIM-3 and hepatocyte galectin-9 signalling protects mouse liver transplants against ischemia-reperfusion injury.

LGALS9C LGALS9B LGALS9

1.01e-074103325450716
Pubmed

The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity.

LGALS9C LGALS9B LGALS9

1.01e-074103316286920
Pubmed

Galectin-9 regulates the threshold of B cell activation and autoimmunity.

LGALS9C LGALS9B LGALS9

1.01e-074103334369876
Pubmed

Targeting the CD146/Galectin-9 axis protects the integrity of the blood-brain barrier in experimental cerebral malaria.

LGALS9C LGALS9B LGALS9

1.01e-074103333203936
Pubmed

Increased expression of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in reactive astrocytes following ischemia.

HCN1 HCN3 HCN2

1.01e-074103325042871
Pubmed

Autism-associated SHANK3 haploinsufficiency causes Ih channelopathy in human neurons.

HCN1 HCN3 HCN2

1.01e-074103326966193
Pubmed

Galectin-9 Targets NLRP3 for Autophagic Degradation to Limit Inflammation.

LGALS9C LGALS9B LGALS9

1.01e-074103333963043
Pubmed

Newly characterized decidual Tim-3+ Treg cells are abundant during early pregnancy and driven by IL-27 coordinately with Gal-9 from trophoblasts.

LGALS9C LGALS9B LGALS9

1.01e-074103333107565
Pubmed

Lipopolysaccharide mediates time-dependent macrophage M1/M2 polarization through the Tim-3/Galectin-9 signalling pathway.

LGALS9C LGALS9B LGALS9

1.01e-074103330763585
Pubmed

Tim-3-Galectin-9 pathway involves the suppression induced by CD4+CD25+ regulatory T cells.

LGALS9C LGALS9B LGALS9

1.01e-074103319362679
Pubmed

Intestinal Lamina Propria CD4+ T Cells Promote Bactericidal Activity of Macrophages via Galectin-9 and Tim-3 Interaction during Salmonella enterica Serovar Typhimurium Infection.

LGALS9C LGALS9B LGALS9

1.01e-074103329844236
Pubmed

Galectin-9/TIM-3 interaction regulates virus-specific primary and memory CD8 T cell response.

LGALS9C LGALS9B LGALS9

1.01e-074103320463811
Pubmed

Lumenal Galectin-9-Lamp2 interaction regulates lysosome and autophagy to prevent pathogenesis in the intestine and pancreas.

LGALS9C LGALS9B LGALS9

1.01e-074103332855403
Pubmed

Galectin-3 mediates oligomerization of secreted hensin using its carbohydrate-recognition domain.

LGALS9C LGALS9B LGALS9

1.01e-074103323657851
Pubmed

The Tim-3/galectin-9 pathway involves in the homeostasis of hepatic Tregs in a mouse model of concanavalin A-induced hepatitis.

LGALS9C LGALS9B LGALS9

1.01e-074103324333756
InteractionHCN4 interactions

HCN4 HCN1 HCN3 HCN2

7.64e-0891024int:HCN4
InteractionLGALS9 interactions

LGALS9C LGALS9B MPDU1 LGALS9 FARSA IGF2BP1 FASN PCCB RPL3 CNOT1 RPL9 ATP5F1B DNMT3A

8.44e-0658810213int:LGALS9
InteractionHCN3 interactions

HCN4 HCN1 HCN3

2.02e-05111023int:HCN3
InteractionNR2C2 interactions

MPDU1 WRN BMS1 LGALS9 RABL6 FARSA IGF2BP1 FASN TSR1 DNAJC11 HPF1 PRKCB NKTR PPIP5K2 PCCB RPL3 HCFC1 PHIP RPL9 ATP5F1B

2.11e-05140310220int:NR2C2
InteractionHCN2 interactions

HCN4 HCN1 HCN2

3.47e-05131023int:HCN2
GeneFamilyCyclic nucleotide gated channels

HCN4 HCN1 HCN3 HCN2

6.60e-0810784250
GeneFamilyGalectins

LGALS9C LGALS9B LGALS14 LGALS9

4.22e-0715784629
GeneFamilyFibronectin type III domain containing

IL12RB2 PTPRT NEO1 EGFLAM SDK1

6.40e-04160785555
GeneFamilyCCR4-NOT transcription complex

CNOT6L CNOT1

9.85e-04117821023
GeneFamilyCyclophilin peptidylprolyl isomerases

PPIL3 NKTR

3.00e-0319782909
ToppCellTracheal-NucSeq-Epithelial-Epi_airway_secretory|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

LGALS9B CAPN13 KSR1 GNA14 DNAH5 SDK1 EPAS1 SLC27A2

1.88e-081961038b07db4a53ab9be9aad6fae5e45f9547db829d096
ToppCellTracheal-NucSeq-Epithelial-Epi_airway_secretory-Secretory_Goblet|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

LGALS9B CAPN13 KSR1 GNA14 DNAH5 SDK1 EPAS1 SLC27A2

1.88e-081961038c366f980cc04abfe1c0c14746c11810c812a42c0
ToppCellT_cells-Tph_and_Tfh|T_cells / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues

HIF1A LGALS9B ATP9A LGALS9 GNA15 TNS3 SLC27A2

1.80e-07176103756c055488e34605d32562571a2fee621b47c9441
ToppCellCF|World / Disease state, Lineage and Cell class

AMPD3 HIF1A CPD IFRD1 SYNE2 PRKCB ZNF292

2.71e-071871037eec4d4e4a658e3a61c05745167a1a5e3d39bb43e
ToppCellHSPCs-Ery_prog.|HSPCs / Lineage and Cell class

ICAM2 WRN LGALS9 IFRD1 GNA14 GNA15 RPL3

2.91e-07189103737d2c45debed1564a40a1085b8b310c50923b9e7
ToppCellTracheal-NucSeq-Epithelial-Epi_airway_basal-Suprabasal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

PTPRT CAPN13 KSR1 GNA15 SDK1 EPAS1 SLC27A2

3.99e-07198103719d8ff3a4f911b13ecc34844202925475ad4d2ab
ToppCellLPS-antiTNF-Hematopoietic_Mast-Mast_cells-Mast-cells|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TSPAN2 GNA14 SLC18A2 TRPV2 PRKCB SLC27A2

1.07e-061441036013223bb2f31eb5bebdbd0908b797d28b96c6f7b
ToppCellAdult-Immune-mast_cell-D122|Adult / Lineage, Cell type, age group and donor

SPTB ALS2 HCN2 SLC18A2 PZP SLC27A2

1.65e-0615510367c9de0591d1bf756b8e268b278bbe10bd5415dcd
ToppCelldroplet-Marrow-nan-3m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IL12RB2 ITGAM SLC25A2 SYNE2 PRKCB MGAT5B

3.32e-061751036cf53a15bfb37b6019e7052ffdf594a9ac040900e
ToppCellCOVID-19-Heart-EC_2|Heart / Disease (COVID-19 only), tissue and cell type

COBLL1 ICAM2 TSPAN2 CNOT6L SYNE2 EPAS1

4.87e-06187103640ffc06a3e3251d9b12da390210d3e045af7537a
ToppCellLPS-IL1RA-Endothelial-Endothelial-Activated_Alv_Cap|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

HYAL1 COBLL1 ICAM2 EGFLAM CTH EPAS1

5.83e-061931036a3636c35ed25aabe2f1aba016c9fe125327bbfaf
ToppCellIPF-Multiplet-Multiplet|World / Disease state, Lineage and Cell class

PTPRT CAPN13 GNA14 SYNE2 DNAH5 SDK1

6.19e-06195103621dbdc803c6947024dc2416e9e21c2ef0af9bc31
ToppCellTracheal-NucSeq-Epithelial-Epi_airway_basal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

COL4A6 PTPRT CAPN13 RPL3 SDK1 EPAS1

6.75e-0619810365374b0e98d669f36a0571d3c006c7bd5e3c8e87f
ToppCellTracheal-NucSeq-Epithelial-Epi_airway_basal-Basal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

COL4A6 PTPRT CAPN13 RPL3 SDK1 EPAS1

6.95e-06199103694a7867e800df352731796de8c24cba133c29622
ToppCellTracheal-NucSeq-Immune_Lymphocytic-T-T_CD3|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

RASGRF1 GRK7 ICAM2 HCN2 PRKCB PZP

6.95e-0619910364be4527f351b701438a8bcb738229a06dbf8bc96
ToppCellTracheal-NucSeq-Immune_Lymphocytic-T-T_CD3-NKT|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

RASGRF1 GRK7 ICAM2 HCN2 PRKCB PZP

6.95e-061991036d3dc52e1f0040763888f951a7c047db4a329a653
ToppCellHealthy/Control|World / Disease group and Cell class

CNOT6L SYNE2 NKTR RPL3 RPL9 ZNF292

6.95e-0619910362623c42b3e79e401a485879b52e8bbcbc581544d
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW10|organoid_Tanaka_cellReport / Sample Type, Dataset, Time_group, and Cell type.

COL4A6 IGF2BP1 NFATC4 SYNE2 HCFC1 PHIP

7.15e-0620010367c495030e6566b81d97b5516d1972e335ce5ed8c
ToppCellTracheal-NucSeq-Immune_Lymphocytic-T-T_CD8-MAIT|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

IL12RB2 ICAM2 IGF2BP1 CNOT6L PRKCB

2.51e-051491035f4bee5fdaaa4a1917e403de90e5a62353006df24
ToppCellControl-Myeloid-Monocytes,_Macrophages-Mast-cells|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

GNA14 TRPV2 PRKCB GNA15 SLC27A2

3.43e-05159103581782e9e370558d61af5e0c760ac9759d69fb725
ToppCellnormal_Pleural_Fluid-B_lymphocytes-Undetermined|normal_Pleural_Fluid / Location, Cell class and cell subclass

COBLL1 PRKCB RPL3 RPL9 ZNF292

3.53e-0516010355744cd30709f38e84f7ec8893dc19d7a288b465a
ToppCellAdult-Immune-mast_cell|Adult / Lineage, Cell type, age group and donor

SPTB HCN2 SLC18A2 PZP SLC27A2

3.64e-05161103544f5c0256b3ce264a6c7b62740f32dcd45ee052d
ToppCellCOVID-19-kidney-Technical/muscle_(Imm)|kidney / Disease (COVID-19 only), tissue and cell type

HCN1 PTPRT RYR1 PRKCB EGFLAM

3.86e-05163103519c28ce16a588a7f4a035c32726f6ccd67702b5b
ToppCellPND03-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP2-CAP2_prolif|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

HYAL1 ICAM2 ALS2 LGALS9 EPAS1

4.46e-051681035c7021748003e5949f7caf7b3291c5bad294948c1
ToppCell367C-Epithelial_cells-Epithelial-B_(AT2)|367C / Donor, Lineage, Cell class and subclass (all cells)

RASGRF1 COBLL1 SLC26A9 ADGRV1 FASN

4.46e-051681035e20e1936573fdde78426d7a4eb45c458d5c4dbb4
ToppCell367C-Epithelial_cells-Epithelial-B_(AT2)-|367C / Donor, Lineage, Cell class and subclass (all cells)

RASGRF1 COBLL1 SLC26A9 ADGRV1 FASN

4.46e-05168103516b517e3159ad6e6d25fd48f7d5f46e77b2b318d
ToppCellControl-Mast_cells|Control / group, cell type (main and fine annotations)

SPTB ALS2 SLC18A2 PRKCB PZP

4.58e-051691035fdb9abca1d0f4fdc32dd8ac6231651ef34aa5afb
ToppCell10x5'v1-week_12-13-Myeloid_neutrophil-granulo-eo/baso/mast-eosinophil|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

ALS2 GNA14 SLC18A2 GNA15 SLC27A2

4.58e-051691035f68195510b91e287fe1507455ca067ece77a3897
ToppCellControl-Mast_cells-Mast_cells|Control / group, cell type (main and fine annotations)

SPTB ALS2 SLC18A2 PRKCB PZP

4.71e-051701035c80f6d29096c372da95a8407f402349ff1bb7018
ToppCellCF-Myeloid-Neutrophil|Myeloid / Disease state, Lineage and Cell class

CPD IFRD1 SYNE2 PRKCB ZNF292

5.41e-0517510358020c3a34f77e68e8149f87481fb1dddd2ac675e
ToppCellFetal_29-31_weeks-Epithelial-club_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ADGRV1 CAPN13 GNA14 DNAH5 SDK1

5.56e-0517610353bbac5c2397535631fce8fa98f6ddb4fe0260351
ToppCellLPS-antiTNF-Endothelial-Endothelial-Alv_Cap|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

HYAL1 ICAM2 EGFLAM CTH EPAS1

6.18e-05180103530cf3c7ee29694eaccb89bf8053a82037d5c9f1d
ToppCell367C-Epithelial_cells-Epithelial-A_(AT2)|367C / Donor, Lineage, Cell class and subclass (all cells)

RASGRF1 COBLL1 SLC26A9 ADGRV1 FASN

6.86e-0518410350ba243cbf69b4fe6ae100a7f0314317bec38026c
ToppCellPCW_10-12-Endothelial-Endothelial_mature-endo_arterial_(9)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

COBLL1 ICAM2 TSPAN2 LGALS9 EGFLAM

6.86e-051841035a809b0fa52df8a159f60f87eefcef61220af5e34
ToppCell367C-Epithelial_cells-Epithelial-A_(AT2)-|367C / Donor, Lineage, Cell class and subclass (all cells)

RASGRF1 COBLL1 SLC26A9 ADGRV1 FASN

6.86e-0518410352a8338e94937686a148b5433515700ca0f674058
ToppCellfacs-Large_Intestine-Distal-3m-Epithelial|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HIF1A CPD CAPN13 GNA14 PDP1

7.04e-051851035fd1911b57927c03470f9387962ca9581e5643fb3
ToppCellfacs-Large_Intestine-Distal-3m|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HIF1A CPD CAPN13 GNA14 PDP1

7.04e-0518510357a18d525de6f874924bfc61b9666b307da86421a
ToppCellLPS-IL1RA+antiTNF-Endothelial-Endothelial-Alv_Cap|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

HYAL1 ICAM2 EGFLAM CTH EPAS1

7.59e-05188103573f6ec915934154f435a376cb274b058ff7c5f35
ToppCell3'-GW_trimst-1-SmallIntestine-Hematopoietic-Myeloid-CLC+_Mast_cell|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ITGAM LGALS9 SLC18A2 PRKCB GNA15

7.59e-051881035ab95a97db1a84bf3e53a4616a83ee81a6ce5ec12
ToppCellHSPCs-Ery/Mk_prog.|World / Lineage and Cell class

IFRD1 GNA14 SLC18A2 GNA15 RPL3

7.59e-0518810355390089213cd6ee90dcdfd3c3f5b6765376cccf2
ToppCellCOPD-Multiplet-Multiplet|World / Disease state, Lineage and Cell class

IL12RB2 CNOT6L GNA14 SYNE2 DNAH5

7.59e-051881035186fe1ea328c942910190a4240262c0d8642ea3b
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c07-TYROBP|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

LGALS9C LGALS9B TSPAN2 SYNE2 HPF1

7.78e-051891035bed43041e6f8ba19787150a6aaa492f2656135d9
ToppCellPCW_07-8.5-Epithelial-Epithelial_alveolar-distal-epi_SFTPC^high_distal_(9)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

COBLL1 ADGRV1 IL22RA1 NUP210 SLC27A2

7.78e-0518910355d9da836ce4308b8458bb3be3871a0aca734b6cd
ToppCellCOVID-19-T_cells-NK_cells|COVID-19 / group, cell type (main and fine annotations)

IL12RB2 CNOT6L SYNE2 PRKCB PZP

7.78e-051891035b699152dfbb8cd8ed724e1e5a51838f29b681b62
ToppCellCD8+_Memory_T_cell-CV-7|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster

IL12RB2 NKTR TMX3 SLC27A2 ZNF292

8.18e-0519110359454f642c3621370fa23640b631301346b300950
ToppCellCOVID-19-lung-CD8+_T_cells|COVID-19 / Disease (COVID-19 only), tissue and cell type

IL12RB2 CNOT6L NUP210 PRKCB PZP

8.18e-051911035543f8ae07cc2e6950c888115a5ca9445e3c0f618
ToppCellCOVID-19-T_cells|COVID-19 / group, cell type (main and fine annotations)

IL12RB2 CNOT6L SYNE2 NUP210 PRKCB

8.18e-0519110357f64add931b64b8d35836fa6bee9ebab593844d3
ToppCellhuman_hepatoblastoma-Tumor_cells|World / Sample and Cell Type and Tumor Cluster (all cells)

WRN NKTR SDK1 PHIP ZNF292

8.38e-051921035916fbec1c7ab7969bda711886ac88e877e30c280
ToppCellLPS-antiTNF-Endothelial-Endothelial-Activated_Alv_Cap|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

HYAL1 ICAM2 EGFLAM CTH EPAS1

8.38e-051921035c618ede75dce3988c87a5b8f98d8e94e1dd66efd
ToppCellEpithelial-alveolar_epithelial_cell_type_2|World / Lineage, Cell type, age group and donor

RASGRF1 COBLL1 SLC26A9 ADGRV1 FASN

8.38e-05192103558c3737be7acce39fd2b91d70d6d7b2bbaa4f710
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d02_child|PBMC_fresh-frozen / Compartment, severity and other cell annotations on 10x 3' data (130k)

HIF1A COBLL1 WRN HSF2 RPL9

8.38e-051921035aee6522d25e012231cdb905ce047295cb64d6e82
ToppCelldroplet-Limb_Muscle-nan-18m-Mesenchymal-smooth_muscle_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COBLL1 GNA14 TRPV2 EGFLAM EPAS1

8.38e-05192103588472b99970ba0decbf87164fc241a1c77b3b389
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

COBLL1 SLC26A9 ADGRV1 FASN DNAH5

8.38e-051921035cc9911e182a289779a2612bc213daae5607689e7
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2-D122|Adult / Lineage, Cell type, age group and donor

RASGRF1 COBLL1 ADGRV1 FASN DNAH5

8.38e-05192103506013a07e3a873b1d1c0451643c528593ac32a9c
ToppCellCOVID-19-kidney-Myeloid|COVID-19 / Disease (COVID-19 only), tissue and cell type

AMPD3 HIF1A CPD ITGAM PRKCB

8.38e-0519210350b9d22a222f1201e375f8e55cace9ef939febae4
ToppCellnucseq-Epithelial-Epithelial_Alveolar-AT2-AT2|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

RASGRF1 COBLL1 SLC26A9 ADGRV1 FASN

8.59e-051931035fd4d3c0d7caf8a2fff5b3d901fc28d19a8163cdf
ToppCelltumor_Lymph_Node_/_Brain-T/NK_cells-CD4+_Th|T/NK_cells / Location, Cell class and cell subclass

WRN CNOT6L GNA15 RPL3 RPL9

8.59e-0519310357fcd6139ac3e1384a1017b6b8152e3431e056f6a
ToppCelldroplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KIF1B GFPT1 IVD PRKCB NKTR

8.59e-051931035471e65f02937bc18d7c5facdacdf1df58cf0f839
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2|Adult / Lineage, Cell type, age group and donor

RASGRF1 COBLL1 SLC26A9 ADGRV1 FASN

8.59e-051931035738f4f0a9ddde2432b429ab46838e353b1790589
ToppCelldroplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KIF1B GFPT1 IVD PRKCB NKTR

8.59e-051931035fe451b3295d77b2bd1ac25cf29310c85835a45fe
ToppCellCOVID-19-lung-CD8+_T_cells|lung / Disease (COVID-19 only), tissue and cell type

IL12RB2 CNOT6L NUP210 PRKCB PZP

8.59e-051931035780e23e2705fc5c1b70e37568b79731ced5038bd
ToppCellhuman_hepatoblastoma|World / Sample and Cell Type and Tumor Cluster (all cells)

WRN NKTR SDK1 PHIP ZNF292

8.59e-051931035e6a688bc834f845ff64dae1be64f073eec5091a1
ToppCellnucseq-Epithelial-Epithelial_Alveolar-AT2|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

RASGRF1 COBLL1 SLC26A9 ADGRV1 FASN

8.59e-051931035f3cc7cfdbc164a4ed42f87647111522b7d393bcb
ToppCellCF-Lymphoid|CF / Disease state, Lineage and Cell class

COBLL1 WRN IVD CNOT6L NUP210

8.59e-05193103511de07d13a7da223990b56fa89ba7fc1c3dd0122
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD4|GI_small-bowel / Manually curated celltypes from each tissue

ICAM2 NEO1 SYNE2 GNA15 EPAS1

8.80e-0519410354547b57669be5d4f0de55175802ee04372288a6a
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

IL12RB2 ITGAM RYR1 PRKCB GNA15

8.80e-0519410351dce6d4b6ac41f80677e3e4c335a4f383bd76f85
ToppCell3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.2.4|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

COBLL1 SLC26A9 GFPT1 FASN RPL9

8.80e-05194103554975e663ed4414b99b3c9a1aa6335613946470f
ToppCelldroplet-Limb_Muscle-MUSCLE-1m-Mesenchymal-smooth_muscle_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COBLL1 GNA14 TRPV2 EGFLAM EPAS1

8.80e-051941035b8a130ffae68ffe550bf335460a1ec1035cf8d8d
ToppCellCOVID-19-lung-CD4+_T_cells_metabolically_active|lung / Disease (COVID-19 only), tissue and cell type

IL12RB2 CNOT6L SYNE2 NUP210 PRKCB

8.80e-0519410352a144a1c2d537c8a59aa419206ddd96c23f0aeab
ToppCellIPF-Multiplet-Multiplet|IPF / Disease state, Lineage and Cell class

PTPRT GNA14 SYNE2 DNAH5 SDK1

9.01e-051951035fce0c29574bb7aab181b9c00feb42681e285d1f2
ToppCellAT2_cells-Donor_08|World / lung cells shred on cell class, cell subclass, sample id

COBLL1 GFPT1 FASN RPL3 EPAS1

9.01e-05195103533f60762f00cd6f4757d8a8d5227141558ac823e
ToppCellIPF-Multiplet|IPF / Disease state, Lineage and Cell class

PTPRT GNA14 SYNE2 DNAH5 SDK1

9.01e-051951035eacc0449ae6f3ad8002268cd061467684c6fb9a7
ToppCellmetastatic_Lymph_Node-T/NK_cells-Cytotoxic_CD8+_T|T/NK_cells / Location, Cell class and cell subclass

TSPAN2 TRPV2 PRKCB PZP RPL3

9.01e-051951035bff726515ea9ce82c223e6c805000afe2e9b7206
ToppCellfacs-Lung-18m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_aerocyte_endothelial_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

AMPD3 HYAL1 ICAM2 EGFLAM TNS3

9.01e-0519510357e0ef92059ff34e368d2324815f49b50e3ca7332
ToppCell3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.3.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

RASGRF1 COBLL1 SLC26A9 ADGRV1 FASN

9.23e-0519610357e5addaa844e66f8160e05858c341866a80aed23
ToppCellCOPD-Multiplet-Multiplet|COPD / Disease state, Lineage and Cell class

ATP9A GNA14 SYNE2 DNAH5 SDK1

9.23e-051961035af4cdc61830685a888a1209826c23bcf54a43084
ToppCellhealthy_donor-Lymphocytic-T_cell-Gamma_Delta_T_cell|healthy_donor / Disease condition, Lineage, Cell class and subclass

IL12RB2 NEO1 SYNE2 RPL3 RPL9

9.23e-0519610356eabbac1625f715531bae562a28da27664572600
ToppCell(05)_Secretory|World / shred by cell type by condition

CPD LGALS9 CAPN13 FASN EPAS1

9.23e-0519610358032c25b51ef96aeba28cc52686a2bd45213453d
ToppCellCOPD-Multiplet|COPD / Disease state, Lineage and Cell class

ATP9A GNA14 SYNE2 DNAH5 SDK1

9.23e-0519610356d02d494196e3f857d53eea46d9419690d43beca
ToppCellCOVID-19-Epithelial-Club,_Basal_cells|Epithelial / Condition, Lineage and Cell class

LGALS9B RYR1 CAPN13 EPAS1 DNMT3A

9.46e-05197103578ed2810e5a765327e7a6da0ca5d4854bf7a0b6f
ToppCellmild-low-quality_cells|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

TBC1D32 SYNE2 NKTR PZP ZNF292

9.46e-051971035e4331969bd911d1ebb5453f40a7057297b5389b4
ToppCellCOVID-19-kidney-Macrophages|COVID-19 / Disease (COVID-19 only), tissue and cell type

AMPD3 ITGAM PRKCB GNA15 TNS3

9.46e-0519710353912301018d0863144dcfac8d1fa8adc081748d7
ToppCellParenchymal-NucSeq-Epithelial-Epi_airway_secretory-Secretory_Goblet|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

LGALS9C LGALS9B CAPN13 SDK1 SLC27A2

9.69e-051981035af07a970afaa435c6433bb5c1cbff4c67af350c7
ToppCell10x3'2.3-week_17-19-Myeloid_neutrophil-granulo-neutrophil-myelocyte|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

AMPD3 KIF1B ITGAM TSPAN2 SYNE2

9.69e-0519810353bc05b8d97a7219af40db7a11aa271f02e74fca5
ToppCellParenchymal-NucSeq-Epithelial-Epi_alveolar-AT2|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

RASGRF1 COBLL1 SLC26A9 ADGRV1 FASN

9.69e-0519810352e2a4e1756bba6f4fbe529559a97d2993c890b4b
ToppCellParenchymal-NucSeq-Epithelial-Epi_airway_secretory-Secretory_Club|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ADGRV1 CAPN13 GNA14 SYNE2 DNAH5

9.69e-0519810351408e02e053ad3406229bfe8189da03be6366e81
ToppCellSigmoid-(1)_T_cell-(14)_Tcm|Sigmoid / shred on region, Cell_type, and subtype

LGALS9C NPR2 LGALS9B RFWD3 PRKCB

9.92e-051991035ec454fa22fb7f50a947bdf4c4bb6f0ba13f62b4c
ToppCell10x5'v1-week_14-16-Myeloid_neutrophil-granulo|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

HIF1A ITGAM TSPAN2 IFRD1 SYNE2

9.92e-0519910355919933c4b842b98fc98685dc8c72c8dd32c6ea3
ToppCellSigmoid-T_cell-Tcm|T_cell / Region, Cell class and subclass

LGALS9C NPR2 LGALS9B RFWD3 PRKCB

9.92e-051991035acdf95f4d58df47690f4ae254245bc618f9ac07e
ToppCellMild/Remission-B_intermediate-0|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)

RASGRF1 COBLL1 PRKCB RPL9 TNS3

9.92e-051991035592111591f0f6816fc56620cb555eb48dabf0758
ToppCell10x_3'_v3-bone_marrow_(10x_3'_v3)-myeloid-myeloid_granulocytic|bone_marrow_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

HIF1A KIF1B ITGAM TSPAN2 IFRD1

9.92e-051991035b7af2b4fe6866cc8c78cf0f78390aab1b1b389ba
ToppCellNS-control-d_0-4-Epithelial-Secretory|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

COBLL1 CPD CAPN13 NKTR EPAS1

9.92e-05199103532bdfff40fd442b88489c8b0f79af3927a51a03c
ToppCelldistal-1-Endothelial-Artery|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

HYAL1 ICAM2 TSPAN2 GNA14 EPAS1

9.92e-051991035fd71d08f6de790a29c880d50d2ed0881952d7791
ToppCellSigmoid-T_cell-Tcm|Sigmoid / Region, Cell class and subclass

LGALS9C NPR2 LGALS9B RFWD3 PRKCB

9.92e-051991035f7c729eaa3c8fd5a05cb6f79cac9b8f199c8092b
ToppCellcontrol-Epithelial-Secretory|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

COBLL1 CPD CAPN13 NKTR EPAS1

9.92e-0519910353d01f90ffd271ca00129192787e4921bdca7e01e
ToppCellcontrol-Epithelial-Secretory|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

COBLL1 CPD CAPN13 NKTR EPAS1

9.92e-051991035262e5b8a52c8ddb0b47048c786e8bdb7158e1b9a
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW10|fetalBrain_Zhong_nature / Sample Type, Dataset, Time_group, and Cell type.

COL4A6 IGF2BP1 NFATC4 SYNE2 HCFC1

9.92e-0519910358e72efcd421639ac36ed036ee13f13de070d361f
ToppCell10x5'v1-week_14-16-Myeloid_neutrophil-granulo-neutrophil|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

HIF1A ITGAM TSPAN2 IFRD1 SYNE2

9.92e-051991035caf2e050b21e7a16ce4e51b3f135debd06810231
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW16-Neuronal-Intermediate|GW16 / Sample Type, Dataset, Time_group, and Cell type.

COL4A6 RASGRF1 SPTB FASN PRKCB

1.02e-042001035a3fcd901cb281920f1bafdfd676399a6dc37355e
ToppCellhealthy_donor|World / Disease condition, Lineage, Cell class and subclass

CNOT6L SYNE2 NKTR RPL3 RPL9

1.02e-042001035afd4d5609adaa470e3d880f8be4a4d55e162b3d6
Drugcyanide

HIF1A HCN4 NOX5 HCN1 HCN3 HCN2 RYR1 PRKCB CTH EPAS1

2.17e-0725410210CID000000768
DrugHCNs

HCN4 HCN1 HCN3 HCN2

1.74e-06201024CID006857665
DrugRapamycin; Down 200; 0.1uM; MCF7; HT_HG-U133A

RABL6 FARSA IFRD1 TSR1 PDP1 NKTR PPIP5K2 CNOT1

2.76e-0619510286927_DN
DrugR59949

HIF1A NOX5 P4HA3 MAPK12 PRKCB

1.57e-05701025CID000657356
Drugnonivamide

NOX5 RYR1 CTH

1.86e-05121023CID000002998
Drugcycloheterophyllin

NOX5 PRKCB

1.99e-0521022CID005316250
DrugNitric Oxide

IL12RB2 HIF1A NOX5 CPD SIRT1 CTH RPL3 EPAS1 ATP5F1B

2.05e-053361029ctd:D009569
Drugivabradine

HCN4 NOX5 HCN1 HCN2

2.77e-05391024CID000132999
DrugRiboflavine [83-88-5]; Down 200; 10.6uM; HL60; HG-U133A

MPDU1 WRN CPD TSR1 PIN4 DNAJC11 ZNF292

2.91e-0519610271767_DN
Diseaseamino acid metabolic disorder (is_implicated_in)

IVD CTH PCCB

5.57e-0611973DOID:9252 (is_implicated_in)
Diseasemeningitis (biomarker_via_orthology)

HCN1 HCN2

1.07e-052972DOID:9471 (biomarker_via_orthology)
Diseasesick sinus syndrome (implicated_via_orthology)

HCN4 HCN1

3.20e-053972DOID:13884 (implicated_via_orthology)
Diseasecutaneous melanoma, hair color

AMPD3 ADGRV1 SYNE2 DNMT3A

5.29e-0562974EFO_0000389, EFO_0003924
Diseasewaist circumference

PTPRT TBC1D32 IGF2BP1 FASN SYNE2 DNAH5 PHIP EPAS1

8.74e-05429978EFO_0004342
Diseasegalectin-9 measurement

LGALS9 KSR1

1.06e-045972EFO_0021863
Diseasepulmonary hypertension (biomarker_via_orthology)

HIF1A HYAL1 RYR1 EPAS1

1.43e-0480974DOID:6432 (biomarker_via_orthology)
DiseaseGeneralized Epilepsy with Febrile Seizures Plus

HCN1 ADGRV1

3.79e-049972C3502809
Diseasetriglycerides in large LDL measurement

COBLL1 SYNE2 PCCB

3.86e-0443973EFO_0022319
Diseasemiddle cerebral artery infarction (implicated_via_orthology)

HIF1A SIRT1 DNMT3A

4.42e-0445973DOID:3525 (implicated_via_orthology)
DiseaseColorectal Carcinoma

COL4A6 FOLH1 WRN PTPRT ZNF432 PRKCB PZP PHIP ZNF292

5.15e-04702979C0009402
Diseasebronchopulmonary dysplasia (biomarker_via_orthology)

HIF1A EPAS1

6.91e-0412972DOID:11650 (biomarker_via_orthology)
Diseasecollagen disease (implicated_via_orthology)

COL4A6 TLR5

6.91e-0412972DOID:854 (implicated_via_orthology)
Diseaseanxiety disorder, stress-related disorder

PTPRT SDK1

6.91e-0412972EFO_0006788, EFO_0010098
Diseasetriglycerides in LDL measurement

COBLL1 SYNE2 PCCB

8.41e-0456973EFO_0022320
Diseasepre-eclampsia (is_marker_for)

HIF1A ITGAM EPAS1

9.32e-0458973DOID:10591 (is_marker_for)
Diseaseprimary biliary cirrhosis

IL12RB2 PRKCB RPL3 DNMT3A

9.89e-04133974EFO_1001486
DiseaseHSV2 virologic severity measurement

KIF1B MGAT5B

1.09e-0315972EFO_0009010
DiseaseP wave duration

HCN1 EPAS1

1.09e-0315972EFO_0005094
DiseaseProfound Mental Retardation

RABL6 FASN PHIP DNMT3A

1.16e-03139974C0020796
DiseaseMental Retardation, Psychosocial

RABL6 FASN PHIP DNMT3A

1.16e-03139974C0025363
DiseaseMental deficiency

RABL6 FASN PHIP DNMT3A

1.16e-03139974C0917816
Diseasetype 2 diabetes mellitus (biomarker_via_orthology)

HIF1A ITGAM EPAS1 ATP5F1B

1.43e-03147974DOID:9352 (biomarker_via_orthology)
Diseasefree androgen index

COBLL1 MPDU1 PPIP5K2 PCCB PHIP EPAS1

1.49e-03374976EFO_0007005
DiseaseDisorder of organic acid metabolism

IVD PCCB

1.58e-0318972cv:C1263739
Diseasecerebral infarction (is_marker_for)

HIF1A ITGAM

1.76e-0319972DOID:3526 (is_marker_for)
Diseasepolycystic kidney disease (biomarker_via_orthology)

HIF1A EPAS1

1.76e-0319972DOID:0080322 (biomarker_via_orthology)
DiseaseParoxysmal atrial fibrillation

HCN4 SIRT1 SYNE2 HSF2

1.78e-03156974C0235480
Diseasefamilial atrial fibrillation

HCN4 SIRT1 SYNE2 HSF2

1.78e-03156974C3468561
DiseasePersistent atrial fibrillation

HCN4 SIRT1 SYNE2 HSF2

1.78e-03156974C2585653
DiseaseAtrial Fibrillation

HCN4 SIRT1 SYNE2 HSF2

1.95e-03160974C0004238
Diseasetemporal lobe epilepsy (is_marker_for)

RASGRF1 HCN1

1.96e-0320972DOID:3328 (is_marker_for)
Diseaseanxiety disorder (implicated_via_orthology)

HCN1 SLC18A2

2.37e-0322972DOID:2030 (implicated_via_orthology)
Diseaseleptin measurement

NOX5 COBLL1 SPTB

2.44e-0381973EFO_0005000
Diseasetriacylglycerol 54:8 measurement

PTPRT PRKCB

2.59e-0323972EFO_0010426
DiseaseHereditary Paraganglioma-Pheochromocytoma Syndrome

KIF1B EPAS1

2.59e-0323972C1708353
Diseaseankylosing spondylitis, psoriasis, ulcerative colitis, Crohn's disease, sclerosing cholangitis

KSR1 FASN PRKCB RPL3 DNMT3A

2.94e-03295975EFO_0000384, EFO_0000676, EFO_0000729, EFO_0003898, EFO_0004268
Diseasetotal brain volume change measurement, age at assessment

COBLL1 EGFLAM

3.05e-0325972EFO_0008007, EFO_0021504
Diseasetestosterone measurement

AMPD3 COBLL1 MPDU1 IVD FASN PIN4 SYNE2 PCCB PHIP EPAS1 TNS3

3.12e-0312759711EFO_0004908

Protein segments in the cluster

PeptideGeneStartEntry
QVVSGQYRMLAKHGG

EPAS1

301

Q99814
GQSMRVGYTLVKHSQ

COL4A6

1461

Q14031
VGGMKEIALHTNRQY

EGFLAM

966

Q63HQ2
RHQGKIMYVGDVRSV

DNMT3A

676

Q9Y6K1
VKYLRQHIGNTLGSM

TBC1D32

56

Q96NH3
YLQHGEQGIMFTTLK

ALS2

1631

Q96Q42
KQMFGPQVLTTRHYV

GPS2

151

Q13227
ILKGIYHQSMSQIYG

ADGRV1

6031

Q8WXG9
TGMVTFYIKGTLQHA

CTH

311

P32929
KILMVQSFSHQYAGI

CAPN13

111

Q6MZZ7
RRYHGVTGLVVMDKN

NPR2

371

P20594
EGNVGYVQMRLKKHR

BMS1

916

Q14692
HQGQEAILQRYRMKG

DCPS

246

Q96C86
SFFLQMQKRVSGHYV

COBLL1

866

Q53SF7
IMELINNVAKAHGGY

ATP5F1B

216

P06576
LVHMQGGILFVYDNK

AMPD3

221

Q01432
QMFHQYSFRGKDLIV

RAVER2

121

Q9HCJ3
FHYLIMAKGVIVRSG

PZP

491

P20742
FAKGVQYNMKIVIRG

RABL6

36

Q3YEC7
QYIPMHGKQIRGLAF

RFWD3

491

Q6PCD5
QTIIIGDNKTQYHMG

HPF1

116

Q9NWY4
IQFHQLMGYVVVGLS

NOX5

311

Q96PH1
VYMLNVKGLARGVFQ

P4HA3

146

Q7Z4N8
QYNFAMNVLGRVKGR

NUP210

1236

Q8TEM1
GVIKGTNVMVTHYFL

HCFC1

1816

P51610
KVLYQFRGVLHQVMV

DNAJC11

526

Q9NVH1
HQFQRMGKLISLFYT

OR10AG1

256

Q8NH19
GTYSLRAGHMKQVNV

NPY4R

251

P50391
VNKYMGLTQFELTGH

HIF1A

116

Q16665
IVKIIGHFYASQMAQ

IGF2BP1

536

Q9NZI8
GNRIIMGKNHVFRFN

KIF1B

621

O60333
KVMVNGSLFVQYFHR

LGALS9C

111

Q6DKI2
VIIRVYHGMNTGYAI

AQP7P3

211

A6NL99
KVMVNGSLFVQYFHR

LGALS9B

111

Q3B8N2
KVMVNGILFVQYFHR

LGALS9

111

O00182
KYHLTVAQVRGGMVF

FOLH1

571

Q04609
IMVGIFSTHYFQQKV

IL12RB2

636

Q99665
FLGILNKYMEIHGTV

MGAT5B

481

Q3V5L5
VKTKFGYHIIMVEGR

PIN4

116

Q9Y237
RQIAQEIIKGMGYLH

KSR1

711

Q8IVT5
GDLMYHIQQVGRFKE

PRKCB

426

P05771
MIFKRLHLGTVAYGL

ATP9A

401

O75110
STFIKQMRIIHGAGY

GNA15

56

P30679
VREGSVGRKMYFIQH

HCN3

456

Q9P1Z3
VGRKMYFIQHGLLSV

HCN3

461

Q9P1Z3
ANILGHENKGVYVLM

IVD

266

P26440
VREAFGQKIGHFQLM

IVD

311

P26440
YKVTLGQMHGLLTER

PDP1

451

Q9P0J1
GTIGKKMYFIQHGVV

HCN4

626

Q9Y3Q4
QHITQMKRGQGYGFK

PTPRT

876

O14522
YAKNIIVGFARMNGR

PCCB

336

P05166
KMYFIQHGVAGVITK

HCN1

511

O60741
IQFMKQVHQGVRGFV

CPD

786

O75976
TFKEVLGSGMQYHLQ

IFRD1

376

O00458
VNRTYQMHLGGKQRE

IL22RA1

171

Q8N6P7
VLEGTGKSQMYVQHR

HYAL1

251

Q12794
LKFHIYNVGTRGLDM

GRK7

276

Q8WTQ7
RYMAQGKHIGKVVVQ

FASN

1841

P49327
YTHYRFRMKQVNIVG

SDK1

1141

Q7Z5N4
RMIHSTNGLYNQFIK

RYR1

401

P21817
TIGKKMYFIQHGVVS

HCN2

576

Q9UL51
MYFIQHGVVSVLTKG

HCN2

581

Q9UL51
RYVSMGQGQEVHARK

DNAH5

4071

Q8TE73
NMYGFRKVVHIDSGI

HSF2

66

Q03933
FIKQMRIIHGSGYSD

GNA14

51

O95837
MIKYGINNIRELVGH

FARSA

466

Q9Y285
ILKYKTQFEGMNHRV

SYNE2

1301

Q8WXH0
KYHMQIVGEIQRGFP

SLC26A9

306

Q7LBE3
ELYHQKSVLIMGRGY

GFPT1

551

Q06210
FYQVHRITGKMVATA

NFATC4

481

Q14934
GSTFHRVVKNFMIQG

NKTR

61

P30414
FLGYKAGMTHIVREV

RPL3

46

P39023
FMNYARKVGAVGRVN

SLC27A2

371

O14975
ATVYIFRVMAQNKHG

NEO1

506

Q92859
RIGPYTFVQQHLMIG

SIRT1

181

Q96EB6
MGINKADIRQVIHYG

WRN

826

Q14191
FIFGQHLRQQRMGTY

ICAM2

246

P13598
YQHIGLVAMFRQNTG

ITGAM

426

P11215
KGRIGVVISSYMHFT

TNS3

111

Q68CZ2
IMFLHQIFYQGLKAR

RASGRF1

296

Q13972
ICFLVMHYRGQTVKG

MPDU1

116

O75352
MHYRGQTVKGVAFLA

MPDU1

121

O75352
RIQVLSMYGKQAGFI

SLC25A2

236

Q9BXI2
IFYSKTHMNVLGVLG

CNOT6L

491

Q96LI5
FSAFVGQMHQQGILK

CNOT1

1876

A5YKK6
MQKRHRVFFVYVGGE

TMX3

146

Q96JJ7
NRLLHIVGYGDFQMK

TSR1

286

Q2NL82
KIRSYFNMIEGQGHG

PHIP

501

Q8WWQ0
HVQNMIKGVTLGFRY

RPL9

76

P32969
IFHRNIKGFMVQTGD

PPIL3

41

Q9H2H8
RIFQAITGLIQHYMK

ZNF292

2181

O60281
GFQHTGIYSVMIQKV

TRPV2

516

Q9Y5S1
GTYSLRAGHMKQVNV

NPY4R2

251

P0DQD5
MIVTGQYGRLFAVVH

MRPL21

86

Q7Z2W9
IFQEAHGMVARKQFG

SPTB

696

P11277
HRVGFQYQGIMQKHT

YLPM1

396

P49750
KVMVNGQRIYNFAHR

LGALS14

101

Q8TCE9
CGKGFTMKRYLIVHQ

ZNF432

546

O94892
QFRYQVMSGPHETLK

ZNF18

46

P17022
IGKGVAIRHVQTMYE

TSPAN2

111

O60636
QLKTVLEMYGHFSGI

PPIP5K2

461

O43314
LEMYGHFSGINRKVQ

PPIP5K2

466

O43314
SQYQLMKHQSIRGFV

TLR5

796

O60602
YLIGTNIFGILAHKM

SLC18A2

341

Q05940
VLEMYGHFSGINRKV

PPIP5K1

476

Q6PFW1
GFRHGNVVAFIIEKM

TEX13B

11

Q9BXU2
LGRMGKHEQALFIYV

VPS39

696

Q96JC1
QMLKGLRYIHAAGII

MAPK12

136

P53778