Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	RWD	UBE2Q2 RWDD1	1.55e-04	11	32	2	SM00591
Domain	RWD	UBE2Q2 RWDD1	1.55e-04	11	32	2	PF05773
Domain	RWD-domain	UBE2Q2 RWDD1	1.86e-04	12	32	2	IPR006575
Domain	-	UBE2Q2 RWDD1	3.44e-03	51	32	2	3.10.110.10
Domain	UBQ-conjugating_enzyme/RWD	UBE2Q2 RWDD1	3.71e-03	53	32	2	IPR016135
Domain	NA-bd_OB-fold	CCAR1 SUPT6H	8.88e-03	83	32	2	IPR012340
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	ROBO1 OS9 CC2D1A NCL PDE3B HAX1 PEAK1 IPO4 LAS1L P4HB NBR1 SUPT6H PCM1 NCBP3 RWDD1	7.75e-13	1487	32	15	33957083
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	CCAR1 NCL POLR1A IPO4 LAS1L SUGP2 P4HB SUPT6H PCM1 XAB2 TUT7	8.48e-12	653	32	11	22586326
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	TAOK2 CCAR1 CC2D1A NCL HAX1 LAS1L SUGP2 P4HB PCM1 XAB2 TUT7 NCBP3	1.46e-09	1371	32	12	36244648
Pubmed	LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells.	STRN4 NCL AMER1 HAX1 LAS1L ANKRD40 SUPT6H PCM1	8.86e-08	639	32	8	23443559
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	NCL POLR1A LAS1L SUGP2 P4HB SUPT6H PCM1 XAB2 NCBP3	2.45e-07	1024	32	9	24711643
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	CCAR1 NCL HAX1 PEAK1 POLR1A IPO4 SBNO1 P4HB NBR1 SUPT6H	3.65e-07	1425	32	10	30948266
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	ROBO1 CC2D1A NCL AMER1 PEAK1 IPO4 SUGP2 PCM1	3.92e-07	777	32	8	35844135
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	CCAR1 NCL LAS1L SUGP2 P4HB SUPT6H TUT7 NCBP3	5.21e-07	807	32	8	22681889
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	TAOK2 STRN4 CCAR1 OS9 POLR1A IPO4 LAS1L P4HB SUPT6H XAB2	5.74e-07	1497	32	10	31527615
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	TAOK2 STRN4 PLPPR3 NCL HAX1 PEAK1 SUGP2 P4HB PCM1	5.97e-07	1139	32	9	36417873
Pubmed	CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.	CCAR1 NCL LAS1L SUGP2 SUPT6H XAB2 NCBP3	1.07e-06	605	32	7	28977666
Pubmed	USP45 and Spindly are part of the same complex implicated in cell migration.	STRN4 CCAR1 P4HB PCM1 TUT7	2.34e-06	235	32	5	30258100
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	CCAR1 NCL IPO4 LAS1L SUGP2 P4HB SUPT6H XAB2	2.38e-06	989	32	8	36424410
Pubmed	Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.	CCAR1 OS9 SUGP2 SBNO1 P4HB PCM1 TUT7	4.60e-06	754	32	7	33060197
Pubmed	Histone chaperone Spt6 is required for class switch recombination but not somatic hypermutation.	NCL SUPT6H	4.92e-06	4	32	2	21518874
Pubmed	The MYO6 interactome reveals adaptor complexes coordinating early endosome and cytoskeletal dynamics.	STRN4 ANKRD40 P4HB PCM1	5.29e-06	125	32	4	29467281
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	CCAR1 OS9 PDE3B AMER1 POLR1A SUGP2 NBR1 SUPT6H PCM1	5.41e-06	1489	32	9	28611215
Pubmed	KSHV episome tethering sites on host chromosomes and regulation of latency-lytic switch by CHD4.	NCL SUGP2 SBNO1 XAB2	6.18e-06	130	32	4	35545047
Pubmed	Defining the membrane proteome of NK cells.	CC2D1A NCL PDE3B IPO4 LAS1L NBR1 PCM1 XAB2	8.10e-06	1168	32	8	19946888
Pubmed	Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.	CCAR1 NCL HAX1 POLR1A LAS1L SUGP2 XAB2	9.81e-06	847	32	7	35850772
Pubmed	A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.	STRN4 HAX1 IPO4 LAS1L SUPT6H XAB2	1.08e-05	560	32	6	35241646
Pubmed	MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis.	NCL LAS1L SUGP2 SBNO1 XAB2	1.39e-05	339	32	5	30415952
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	TAOK2 LAS1L SBNO1 XAB2 NCBP3	1.43e-05	341	32	5	32971831
Pubmed	A protein-RNA interaction atlas of the ribosome biogenesis factor AATF.	CCAR1 NCL NBR1 NCBP3	1.47e-05	162	32	4	31363146
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	CCAR1 ROBO1 OS9 NCL P4HB NBR1 PCM1 XAB2	1.73e-05	1297	32	8	33545068
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	CCAR1 NCL LAS1L SUGP2 PCM1 XAB2 NCBP3	2.11e-05	954	32	7	36373674
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	CCAR1 IPO4 LAS1L SUGP2 P4HB SUPT6H	2.25e-05	638	32	6	33239621
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	CCAR1 NCL POLR1A IPO4 LAS1L SUGP2 P4HB TUT7	2.35e-05	1353	32	8	29467282
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	OS9 CC2D1A NCL HAX1 IPO4 P4HB PCM1	2.41e-05	974	32	7	28675297
Pubmed	Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.	IPO4 SBNO1 SUPT6H XAB2 NCBP3 RWDD1	2.56e-05	653	32	6	33742100
Pubmed	Delineating the HMGB1 and HMGB2 interactome in prostate and ovary epithelial cells and its relationship with cancer.	CCAR1 NCL SUPT6H NCBP3	2.64e-05	188	32	4	29721183
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	CCAR1 NCL POLR1A SUGP2 SBNO1 SUPT6H XAB2	3.12e-05	1014	32	7	32416067
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	CC2D1A NCL HAX1 SBNO1 P4HB NBR1 SUPT6H XAB2	3.23e-05	1415	32	8	28515276
Pubmed	Interactomes of Glycogen Synthase Kinase-3 Isoforms.	ROBO1 PEAK1 NBR1 PCM1	3.99e-05	209	32	4	36779422
Pubmed	Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15.	NCL LAS1L SUGP2 P4HB XAB2 NCBP3	4.21e-05	714	32	6	28302793
Pubmed	The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1.	STRN4 CCAR1 SUGP2 SUPT6H	4.22e-05	212	32	4	33853758
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	CCAR1 CC2D1A POLR1A LAS1L SUGP2 XAB2	4.55e-05	724	32	6	36232890
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	CCAR1 NCL HAX1 SUGP2 P4HB SUPT6H XAB2	4.71e-05	1082	32	7	38697112
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	NCL POLR1A LAS1L SUPT6H TUT7	4.81e-05	440	32	5	34244565
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	ROBO1 OS9 POLR1A NBR1 PCM1 TUT7	4.88e-05	733	32	6	34672954
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	NCL POLR1A LAS1L SUGP2 TUT7 NCBP3	5.91e-05	759	32	6	35915203
Pubmed	New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.	NCL HAX1 SUGP2 PCM1 NCBP3	6.06e-05	462	32	5	31138677
Pubmed	High-sensitivity profiling of SARS-CoV-2 noncoding region-host protein interactome reveals the potential regulatory role of negative-sense viral RNA.	NCL SUGP2 P4HB XAB2 TUT7	6.51e-05	469	32	5	37314180
Pubmed	Human Antiviral Protein IFIX Suppresses Viral Gene Expression during Herpes Simplex Virus 1 (HSV-1) Infection and Is Counteracted by Virus-induced Proteasomal Degradation.	LAS1L SUGP2 SUPT6H XAB2	8.12e-05	251	32	4	28077445
Pubmed	Isoform-specific GSK3A activity is negatively correlated with human sperm motility.	SUGP2 SBNO1 NBR1	8.40e-05	92	32	3	30824926
Pubmed	Wnt regulation: exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex.	STRN4 CCAR1 NCL AMER1 HAX1 P4HB	8.41e-05	809	32	6	32129710
Pubmed	A Compendium of RNA-Binding Proteins that Regulate MicroRNA Biogenesis.	CCAR1 SUGP2 XAB2 TUT7	8.51e-05	254	32	4	28431233
Pubmed	The WTX Tumor Suppressor Interacts with the Transcriptional Corepressor TRIM28.	AMER1 SUGP2	8.55e-05	15	32	2	25882849
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	CC2D1A NCL IPO4 LAS1L PCM1	9.05e-05	503	32	5	16964243
Pubmed	RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.	PDE3B PEAK1 P4HB NBR1	9.73e-05	263	32	4	34702444
Pubmed	Inhibition of USP1 reverses the chemotherapy resistance through destabilization of MAX in the relapsed/refractory B-cell lymphoma.	OS9 SUPT6H	1.11e-04	17	32	2	36352191
Pubmed	KCTD9 inhibits the Wnt/β-catenin pathway by decreasing the level of β-catenin in colorectal cancer.	NCL IPO4 P4HB	1.21e-04	104	32	3	36055981
Pubmed	RNF168 and USP10 regulate topoisomerase IIα function via opposing effects on its ubiquitylation.	NCL PCM1	1.24e-04	18	32	2	27558965
Pubmed	Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.	NCL HAX1 LAS1L	1.24e-04	105	32	3	22505724
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	STRN4 CC2D1A PEAK1 SUGP2 PCM1	1.36e-04	549	32	5	38280479
Pubmed	ESYT1 tethers the ER to mitochondria and is required for mitochondrial lipid and calcium homeostasis.	TAOK2 PDE3B HAX1 P4HB	1.59e-04	299	32	4	37931956
Pubmed	R2TP/Prefoldin-like component RUVBL1/RUVBL2 directly interacts with ZNHIT2 to regulate assembly of U5 small nuclear ribonucleoprotein.	POLR1A SUGP2 PCM1 XAB2	1.61e-04	300	32	4	28561026
Pubmed	Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.	STRN4 HAX1 PEAK1 LAS1L P4HB	1.66e-04	573	32	5	28330616
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	TAOK2 PDE3B POLR1A IPO4 NBR1 TUT7	1.93e-04	942	32	6	31073040
Pubmed	Quantitative interactome proteomics identifies a proteostasis network for GABAA receptors.	HAX1 P4HB PCM1	2.08e-04	125	32	3	36030824
Pubmed	Proximity labeling reveals dynamic changes in the SQSTM1 protein network.	CC2D1A AMER1 HAX1 NBR1	2.11e-04	322	32	4	39098523
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	TAOK2 STRN4 CCAR1 NCL IPO4 PCM1	2.17e-04	963	32	6	28671696
Pubmed	The necdin interactome: evaluating the effects of amino acid substitutions and cell stress using proximity-dependent biotinylation (BioID) and mass spectrometry.	STRN4 CC2D1A NCL PCM1	2.32e-04	330	32	4	32529326
Pubmed	Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.	NCL LAS1L P4HB XAB2	2.37e-04	332	32	4	32786267
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	STRN4 NCL HAX1 PEAK1 SUGP2 P4HB PCM1	2.68e-04	1431	32	7	37142655
Pubmed	The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted antiviral signaling and host translation.	CCAR1 OS9 CC2D1A PEAK1 P4HB PCM1	2.76e-04	1007	32	6	34597346
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	OS9 HAX1 IPO4 LAS1L PCM1 NCBP3 RWDD1	2.78e-04	1440	32	7	30833792
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	STRN4 NCL ARMC9 IPO4 SBNO1 ANKRD40 P4HB	2.96e-04	1455	32	7	22863883
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	CCAR1 NCL PDE3B XAB2 TUT7	2.98e-04	650	32	5	38777146
Pubmed	Compartmentalization of the SUMO/RNF4 pathway by SLX4 drives DNA repair.	NCL SUGP2 SBNO1 XAB2	3.13e-04	357	32	4	37059091
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	CC2D1A AMER1 HAX1 LAS1L TAF13 RWDD1	3.25e-04	1038	32	6	26673895
Pubmed	HIV-1 Vpr induces cell cycle arrest and enhances viral gene expression by depleting CCDC137.	NCL SUGP2 XAB2	3.42e-04	148	32	3	32538781
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	STRN4 NCL PDE3B HAX1 LAS1L NBR1 TUT7	3.51e-04	1496	32	7	32877691
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	AMER1 PEAK1 ANKRD40 P4HB UBE2Q2 TUT7	4.09e-04	1084	32	6	11544199
Pubmed	Systematic and quantitative assessment of the ubiquitin-modified proteome.	NCL HAX1 LAS1L	4.14e-04	158	32	3	21906983
Pubmed	ATG5 is required for B cell polarization and presentation of particulate antigens.	CCAR1 NCL POLR1A PCM1 TUT7	4.21e-04	701	32	5	30196744
Pubmed	p62/SQSTM1 Fuels Melanoma Progression by Opposing mRNA Decay of a Selective Set of Pro-metastatic Factors.	TAOK2 ROBO1 NBR1	4.22e-04	159	32	3	30581152
Pubmed	Autophagosomal Content Profiling Reveals an LC3C-Dependent Piecemeal Mitophagy Pathway.	NBR1 PCM1	4.25e-04	33	32	2	29149599
Pubmed	KAP1 facilitates reinstatement of heterochromatin after DNA replication.	CCAR1 HAX1 POLR1A IPO4 SUGP2	4.29e-04	704	32	5	29955894
Pubmed	A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.	NCL HAX1 LAS1L	4.46e-04	162	32	3	21890473
Pubmed	A Chemical Proteomics Approach to Reveal Direct Protein-Protein Interactions in Living Cells.	NCL P4HB	4.79e-04	35	32	2	29104064
Pubmed	The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin.	NCL POLR1A IPO4 LAS1L	4.80e-04	400	32	4	35013556
Pubmed	Disease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation.	LAS1L SUGP2	5.07e-04	36	32	2	35379950
Pubmed	Exploring an Alternative Cysteine-Reactive Chemistry to Enable Proteome-Wide PPI Analysis by Cross-Linking Mass Spectrometry.	STRN4 NCL IPO4 TUT7	5.32e-04	411	32	4	36652389
Pubmed	CRISPR activation screen identifies BCL-2 proteins and B3GNT2 as drivers of cancer resistance to T cell-mediated cytotoxicity.	OS9 NCL IPO4 P4HB	5.67e-04	418	32	4	35338135
Pubmed	Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level.	NCL HAX1 LAS1L	6.05e-04	180	32	3	21139048
Pubmed	Analysis of the Histone H3.1 Interactome: A Suitable Chaperone for the Right Event.	CCAR1 IPO4 SUPT6H	6.25e-04	182	32	3	26527279
Pubmed	Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics.	OS9 IPO4 P4HB	6.35e-04	183	32	3	23956138
Pubmed	URI Regulates KAP1 Phosphorylation and Transcriptional Repression via PP2A Phosphatase in Prostate Cancer Cells.	POLR1A SUPT6H	6.90e-04	42	32	2	27780869
Pubmed	Dynamic protein-protein interaction wiring of the human spliceosome.	CCAR1 XAB2 NCBP3	7.87e-04	197	32	3	22365833
Pubmed	Defining the Na+/H+ exchanger NHE1 interactome in triple-negative breast cancer cells.	NCL P4HB	8.28e-04	46	32	2	27751915
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	NCL IPO4 TUT7	8.46e-04	202	32	3	33005030
Pubmed	C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.	NCL HAX1 POLR1A IPO4 LAS1L P4HB	8.91e-04	1257	32	6	37317656
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	NCL IPO4 LAS1L P4HB XAB2 TUT7	8.91e-04	1257	32	6	36526897
Interaction	SIRT7 interactions	CCAR1 NCL POLR1A IPO4 LAS1L SUGP2 P4HB SUPT6H PCM1 XAB2 TUT7	6.95e-09	744	31	11	int:SIRT7
Interaction	OBSL1 interactions	NCL HAX1 POLR1A LAS1L SUGP2 SUPT6H PCM1 XAB2 TUT7 NCBP3	5.77e-07	902	31	10	int:OBSL1
Interaction	ATG16L1 interactions	STRN4 CCAR1 ROBO1 CC2D1A NCL POLR1A IPO4 NBR1 PCM1 TUT7	5.64e-06	1161	31	10	int:ATG16L1
Interaction	SYNGAP1 interactions	TAOK2 CCAR1 NCL HAX1 PEAK1 SUGP2	6.36e-06	307	31	6	int:SYNGAP1
Interaction	POLR1G interactions	NCL POLR1A IPO4 LAS1L SBNO1 SUPT6H NCBP3	7.53e-06	489	31	7	int:POLR1G
Interaction	CPSF6 interactions	TAOK2 CCAR1 SUGP2 P4HB SUPT6H XAB2 NCBP3	1.21e-05	526	31	7	int:CPSF6
Interaction	EGLN3 interactions	TAOK2 ROBO1 OS9 PDE3B AMER1 HAX1 PEAK1 IPO4 LAS1L PCM1	1.49e-05	1296	31	10	int:EGLN3
Interaction	RBM39 interactions	TAOK2 CCAR1 NCL CLUAP1 LAS1L SUGP2 P4HB XAB2 NCBP3	1.83e-05	1042	31	9	int:RBM39
Interaction	BIRC3 interactions	CCAR1 NCL HAX1 PEAK1 POLR1A IPO4 P4HB NBR1 SUPT6H UBE2Q2	1.92e-05	1334	31	10	int:BIRC3
Interaction	DUSP16 interactions	AMER1 HAX1 LAS1L NBR1 PCM1	2.85e-05	237	31	5	int:DUSP16
Interaction	MIRLET7G interactions	CCAR1 SUGP2 XAB2 TUT7	3.01e-05	117	31	4	int:MIRLET7G
Interaction	RNF2 interactions	NCL POLR1A IPO4 LAS1L SUGP2 P4HB XAB2 NCBP3	3.68e-05	866	31	8	int:RNF2
Interaction	GSK3A interactions	ROBO1 PEAK1 SUGP2 SBNO1 NBR1 PCM1	6.51e-05	464	31	6	int:GSK3A
Interaction	DNAJC25 interactions	OS9 NCL PDE3B HAX1 P4HB	6.75e-05	284	31	5	int:DNAJC25
Interaction	CEP250 interactions	AMER1 HAX1 LAS1L SUPT6H PCM1	7.10e-05	287	31	5	int:CEP250
Interaction	DDX23 interactions	NCL LAS1L NBR1 SUPT6H PCM1 XAB2	7.85e-05	480	31	6	int:DDX23
Interaction	GABRA1 interactions	OS9 HAX1 P4HB PCM1	8.35e-05	152	31	4	int:GABRA1
Interaction	SENP3 interactions	IPO4 LAS1L SUGP2 XAB2 NCBP3	8.88e-05	301	31	5	int:SENP3
Interaction	SLC66A1LP interactions	ANKRD40 NBR1	1.02e-04	10	31	2	int:SLC66A1LP
Interaction	STIP1 interactions	CCAR1 HAX1 IPO4 LAS1L SUGP2 P4HB NBR1 SUPT6H	1.06e-04	1006	31	8	int:STIP1
Interaction	SPDL1 interactions	STRN4 CCAR1 P4HB PCM1 TUT7	1.10e-04	315	31	5	int:SPDL1
Interaction	CHD3 interactions	CCAR1 NCL LAS1L SUGP2 SBNO1 SUPT6H NCBP3	1.23e-04	757	31	7	int:CHD3
Interaction	GOLGA1 interactions	STRN4 PEAK1 NBR1 PCM1	1.71e-04	183	31	4	int:GOLGA1
Interaction	CCDC65 interactions	NCL PCM1	2.06e-04	14	31	2	int:CCDC65
Interaction	DNAJC1 interactions	CC2D1A NCL PDE3B P4HB RWDD1	2.08e-04	361	31	5	int:DNAJC1
Interaction	AATF interactions	CCAR1 NCL POLR1A NBR1 NCBP3	2.51e-04	376	31	5	int:AATF
Interaction	GSK3B interactions	ROBO1 NCL HAX1 PEAK1 P4HB NBR1 PCM1	2.85e-04	868	31	7	int:GSK3B
Interaction	TPTE2 interactions	STRN4 IPO4 PCM1	2.89e-04	84	31	3	int:TPTE2
Interaction	C9orf78 interactions	STRN4 HAX1 IPO4 LAS1L SUPT6H XAB2	3.16e-04	620	31	6	int:C9orf78
Interaction	CEP104 interactions	CC2D1A P4HB PCM1	3.42e-04	89	31	3	int:CEP104
Interaction	CDK8 interactions	LAS1L SUGP2 SBNO1 XAB2	3.57e-04	222	31	4	int:CDK8
Interaction	PURG interactions	NCL SUGP2 XAB2 TUT7	3.63e-04	223	31	4	int:PURG
Interaction	ERCC6 interactions	NCL POLR1A SUPT6H XAB2	3.69e-04	224	31	4	int:ERCC6
Interaction	MAPRE3 interactions	TAOK2 ZNF526 HAX1 TUT7	4.08e-04	230	31	4	int:MAPRE3
Interaction	BMI1 interactions	NCL LAS1L SUGP2 P4HB SUPT6H NCBP3	4.37e-04	659	31	6	int:BMI1
Interaction	RNF43 interactions	PDE3B PEAK1 SUGP2 P4HB NBR1	4.50e-04	427	31	5	int:RNF43
Interaction	MIR106B interactions	CCAR1 SUGP2 XAB2	4.54e-04	98	31	3	int:MIR106B
Interaction	CHD4 interactions	CCAR1 NCL LAS1L SUGP2 SUPT6H XAB2 NCBP3	4.56e-04	938	31	7	int:CHD4
Interaction	SRP19 interactions	NCL LAS1L SUPT6H NCBP3	5.10e-04	244	31	4	int:SRP19
Interaction	RPL31 interactions	CC2D1A NCL LAS1L SUPT6H TUT7 NCBP3	5.17e-04	680	31	6	int:RPL31
Interaction	TTC8 interactions	CLUAP1 PCM1	5.19e-04	22	31	2	int:TTC8
Interaction	HSP90AB1 interactions	CCAR1 CC2D1A CLUAP1 HAX1 PEAK1 P4HB NBR1	5.24e-04	960	31	7	int:HSP90AB1
Interaction	SYNE3 interactions	TAOK2 CC2D1A PDE3B P4HB NBR1	5.37e-04	444	31	5	int:SYNE3
Interaction	ZNF330 interactions	NCL IPO4 LAS1L SUPT6H NCBP3	5.48e-04	446	31	5	int:ZNF330
Interaction	MIRLET7E interactions	SUGP2 XAB2 TUT7	5.71e-04	106	31	3	int:MIRLET7E
Interaction	NDN interactions	STRN4 CCAR1 CC2D1A NCL PCM1	5.89e-04	453	31	5	int:NDN
Interaction	SMC5 interactions	CCAR1 NCL LAS1L SUGP2 PCM1 XAB2 NCBP3	6.69e-04	1000	31	7	int:SMC5
Interaction	IGF1R interactions	TAOK2 OS9 HAX1 PEAK1 P4HB	6.75e-04	467	31	5	int:IGF1R
Interaction	CDC42 interactions	TAOK2 ROBO1 NCL PDE3B PEAK1 IPO4 SBNO1 PCM1	6.83e-04	1323	31	8	int:CDC42
Interaction	SRPK2 interactions	CCAR1 NCL AMER1 LAS1L SUPT6H NCBP3	6.83e-04	717	31	6	int:SRPK2
Interaction	CSNK2A2 interactions	STRN4 NCL CLUAP1 POLR1A LAS1L P4HB	6.88e-04	718	31	6	int:CSNK2A2
Interaction	MIRLET7I interactions	SUGP2 XAB2 TUT7	7.06e-04	114	31	3	int:MIRLET7I
Interaction	RECQL5 interactions	NCL POLR1A SUPT6H	7.06e-04	114	31	3	int:RECQL5
Interaction	HAP1 interactions	CC2D1A NBR1 PCM1	7.24e-04	115	31	3	int:HAP1
Interaction	TYSND1 interactions	ANKRD40 NBR1	7.27e-04	26	31	2	int:TYSND1
Interaction	PLPPR3 interactions	STRN4 PLPPR3	7.27e-04	26	31	2	int:PLPPR3
Interaction	NXF1 interactions	STRN4 NCL CLUAP1 POLR1A IPO4 ANKRD40 SUPT6H NCBP3	7.62e-04	1345	31	8	int:NXF1
Interaction	SNRPA interactions	CCAR1 NBR1 SUPT6H XAB2 NCBP3	7.79e-04	482	31	5	int:SNRPA
Interaction	H3C8 interactions	IPO4 SUPT6H	7.85e-04	27	31	2	int:H3C8
Interaction	DUSP23 interactions	HAX1 IPO4 P4HB	8.00e-04	119	31	3	int:DUSP23
Interaction	PCOLCE2 interactions	STRN4 OS9	8.44e-04	28	31	2	int:PCOLCE2
Interaction	WRAP73 interactions	CCAR1 HAX1 PCM1	8.80e-04	123	31	3	int:WRAP73
Interaction	CBX6 interactions	NCL LAS1L SUGP2 TUT7	8.88e-04	283	31	4	int:CBX6
Interaction	ARHGAP39 interactions	TAOK2 PEAK1 P4HB	9.01e-04	124	31	3	int:ARHGAP39
Interaction	FUS interactions	CCAR1 NCL NBR1 SUPT6H PCM1 XAB2	9.07e-04	757	31	6	int:FUS
Interaction	IQGAP2 interactions	CLUAP1 HAX1 POLR1A	9.22e-04	125	31	3	int:IQGAP2
Cytoband	2q37.1	NCL ARMC9	1.01e-03	67	32	2	2q37.1
Cytoband	Ensembl 112 genes in cytogenetic band chr19p13	PLPPR3 CC2D1A SUGP2 XAB2	2.20e-03	797	32	4	chr19p13
Cytoband	Ensembl 112 genes in cytogenetic band chr15q24	PEAK1 UBE2Q2	3.30e-03	122	32	2	chr15q24
Cytoband	19q13.2	STRN4 ZNF526	5.86e-03	164	32	2	19q13.2
Coexpression	HOUNKPE_HOUSEKEEPING_GENES	TAOK2 STRN4 OS9 NCL HAX1 ANKRD40 P4HB SUPT6H	4.82e-05	1129	32	8	M42508
Coexpression	HOUNKPE_HOUSEKEEPING_GENES	TAOK2 STRN4 OS9 NCL HAX1 ANKRD40 P4HB SUPT6H	5.77e-05	1158	32	8	MM1338
Coexpression	GSE29618_PRE_VS_DAY7_POST_TIV_FLU_VACCINE_MONOCYTE_DN	TAOK2 STRN4 SUGP2 SUPT6H	9.81e-05	199	32	4	M4997
Coexpression	GSE5589_LPS_VS_LPS_AND_IL10_STIM_IL6_KO_MACROPHAGE_180MIN_DN	IPO4 ANKRD40 UBE2Q2 RWDD1	1.00e-04	200	32	4	M6624
Coexpression	GSE2770_UNTREATED_VS_IL12_TREATED_ACT_CD4_TCELL_48H_DN	CCAR1 LAS1L SBNO1 PCM1	1.00e-04	200	32	4	M6045
Coexpression	GSE20715_WT_VS_TLR4_KO_6H_OZONE_LUNG_DN	OS9 CLUAP1 LAS1L XAB2	1.00e-04	200	32	4	M4352
Drug	Quinidine hydrochloride monohydrate [6151-40-2]; Down 200; 10.6uM; MCF7; HT_HG-U133A	CC2D1A SUGP2 ANKRD40 SUPT6H PCM1 XAB2	2.84e-07	196	32	6	6267_DN
Drug	Triflupromazine hydrochloride [1098-60-8]; Down 200; 10.2uM; HL60; HT_HG-U133A	CC2D1A PDE3B ANKRD40 SUPT6H PCM1	7.68e-06	197	32	5	1855_DN
Drug	Azathioprine [446-86-6]; Down 200; 14.4uM; PC3; HG-U133A	TAOK2 OS9 CC2D1A SUPT6H PCM1	8.06e-06	199	32	5	1945_DN
Drug	Carcinine [56897-53-1]; Down 200; 22uM; MCF7; HT_HG-U133A	PDE3B SUGP2 TAF13 PCM1	1.49e-04	193	32	4	3242_DN
Drug	Quercetine dihydrate [6151-25-3]; Down 200; 11.8uM; MCF7; HT_HG-U133A	PDE3B TAF13 ANKRD40 PCM1	1.49e-04	193	32	4	4846_DN
Drug	Melatonin [73-31-4]; Down 200; 17.2uM; MCF7; HT_HG-U133A	TAOK2 CC2D1A PDE3B PCM1	1.49e-04	193	32	4	3293_DN
Drug	Mefenamic acid [61-68-7]; Down 200; 16.6uM; MCF7; HT_HG-U133A	PDE3B SUGP2 ANKRD40 SUPT6H	1.52e-04	194	32	4	1699_DN
Drug	Hesperetin [520-33-2]; Down 200; 13.2uM; PC3; HG-U133A	STRN4 CC2D1A PCM1 NCBP3	1.52e-04	194	32	4	1947_DN
Drug	PNU-0230031 [267429-39-0]; Down 200; 1uM; PC3; HT_HG-U133A	TAOK2 SUGP2 SUPT6H XAB2	1.52e-04	194	32	4	4291_DN
Drug	Megestrol acetate [595-33-5]; Up 200; 10.4uM; HL60; HT_HG-U133A	TAOK2 FAM174B PLPPR3 ARMC9	1.55e-04	195	32	4	3091_UP
Drug	Azathymine, 6 [932-53-6]; Down 200; 31.4uM; MCF7; HT_HG-U133A	TAOK2 PDE3B SUGP2 PCM1	1.55e-04	195	32	4	4106_DN
Drug	Ofloxacin [82419-36-1]; Down 200; 11uM; HL60; HT_HG-U133A	CC2D1A PDE3B SUPT6H PCM1	1.55e-04	195	32	4	2340_DN
Drug	Cephapirin sodium salt [24356-60-3]; Down 200; 9uM; PC3; HT_HG-U133A	SUGP2 SUPT6H PCM1 NCBP3	1.59e-04	196	32	4	7142_DN
Drug	0179445-0000 [211246-22-9]; Down 200; 1uM; PC3; HT_HG-U133A	STRN4 FAM174B SUGP2 XAB2	1.59e-04	196	32	4	4292_DN
Drug	Isoxsuprine hydrochloride [579-56-6]; Up 200; 11.8uM; PC3; HG-U133A	FAM174B PDE3B SBNO1 XAB2	1.59e-04	196	32	4	1904_UP
Drug	Clindamycin hydrochloride [21462-39-5]; Down 200; 8.6uM; PC3; HT_HG-U133A	CC2D1A SUGP2 SUPT6H XAB2	1.62e-04	197	32	4	5815_DN
Drug	Chlorpropamide [94-20-2]; Down 200; 14.4uM; PC3; HT_HG-U133A	FAM174B SUGP2 SUPT6H PCM1	1.62e-04	197	32	4	6291_DN
Drug	Nicardipine hydrochloride [54527-84-3]; Down 200; 7.8uM; PC3; HT_HG-U133A	SUGP2 ANKRD40 SUPT6H PCM1	1.65e-04	198	32	4	6297_DN
Drug	Benzydamine hydrochloride [132-69-4]; Down 200; 11.6uM; MCF7; HT_HG-U133A	CC2D1A SUGP2 SUPT6H PCM1	1.65e-04	198	32	4	7169_DN
Drug	Furaltadone hydrochloride [3759-92-0]; Down 200; 11uM; MCF7; HT_HG-U133A	FAM174B OS9 CC2D1A SUGP2	1.65e-04	198	32	4	3413_DN
Drug	Metformin hydrochloride [1115-70-4]; Up 200; 24.2uM; PC3; HT_HG-U133A	FAM174B SUPT6H XAB2 NCBP3	1.65e-04	198	32	4	5068_UP
Drug	Hydrochlorothiazide [58-93-5]; Up 200; 13.4uM; PC3; HG-U133A	TAOK2 SBNO1 ANKRD40 PCM1	1.65e-04	198	32	4	1906_UP
Drug	Neostigmine bromide [114-80-7]; Down 200; 13.2uM; MCF7; HT_HG-U133A	TAOK2 FAM174B CC2D1A XAB2	1.65e-04	198	32	4	5335_DN
Drug	Dihydroergotamine tartrate [5989-77-5]; Down 200; 3uM; MCF7; HT_HG-U133A	PDE3B ANKRD40 PCM1 XAB2	1.68e-04	199	32	4	6840_DN
Drug	Ungerine nitrate; Down 200; 10.2uM; MCF7; HT_HG-U133A	TAOK2 STRN4 ANKRD40 SUPT6H	1.68e-04	199	32	4	7173_DN
Drug	Doxycycline hydrochloride [10592-13-9]; Down 200; 8.4uM; PC3; HT_HG-U133A	FAM174B ROBO1 SUGP2 SUPT6H	1.68e-04	199	32	4	5838_DN
Drug	Piperacetazine [3819-00-9]; Down 200; 9.8uM; MCF7; HT_HG-U133A	TAOK2 STRN4 SUGP2 XAB2	1.68e-04	199	32	4	7191_DN
Drug	Pseudopelletierine hydrochloride [6164-62-1]; Down 200; 21uM; PC3; HT_HG-U133A	FAM174B SUGP2 SUPT6H NCBP3	1.71e-04	200	32	4	5828_DN
Drug	AC1NSSBO	TAOK2 ARMC9	1.72e-04	14	32	2	CID005369103
Disease	facial emotion recognition measurement	ROBO1 POLR1A	6.63e-04	35	32	2	EFO_0008329
Disease	bipolar disorder	TAOK2 PDE3B HAX1 POLR1A	3.37e-03	577	32	4	MONDO_0004985
Disease	Vertigo	ARMC9 PEAK1	9.96e-03	139	32	2	HP_0002321
Disease	Intellectual Disability	ZNF526 ARMC9 LAS1L	1.24e-02	447	32	3	C3714756

Protein segments in the cluster

Peptide	Gene	Start	Entry
DPMEAEEAEDEEDDR	CCAR1	871	Q8IX12
EEAEDEEDDRDEEEM	CCAR1	876	Q8IX12
VEMAPLNEEDDEDED	FAM174B	136	Q3ZCQ3
EMALPDDDDEEEEEE	AMER1	371	Q5JTC6
KIMGVEEEDDDDDDD	ANKRD40	91	Q6AI12
GMTRDEDDDEEEEEE	HAX1	26	O00165
EDEDDEEDHDIMEAD	ARMC9	586	Q7Z3E5
DENEDEEMEEFEEGP	PCM1	1801	Q15154
DDEDGEELDTEDEEM	PDE3B	1026	Q13370
EDPDDPEKDEDDMEE	PEAK1	1406	Q9H792
EEEEEEEEEDQDMDA	NCBP3	351	Q53F19
DDEDDEEEDRMEVGP	LAS1L	596	Q9Y4W2
DDDLEDLEEAEEPDM	P4HB	481	P07237
DLEEAEEPDMEEDDD	P4HB	486	P07237
EDEDEDEDEIEPAAM	NCL	161	P19338
MRDPDEDEEEGTDED	CC2D1A	81	Q6P1N0
DEPEEEDEEEMGHAE	SBNO1	226	A3KN83
DDESDGEEEEELMDE	IPO4	636	Q8TEX9
LGEDEDEDEMDLEPN	XAB2	821	Q9HCS7
EEEEREGEENDDEDM	POLR1A	1431	O95602
AEEEAVMEEEEDEED	NBR1	696	Q14596
EEEEEEEGPEAREMA	TAOK2	386	Q9UL54
MADEEEDPTFEEENE	TAF13	1	Q15543
DPERQREMEEEEDED	OS9	406	Q13438
EIDMEDDDDEDDDLE	CLUAP1	371	Q96AJ1
MAPPEEEEEDDEESD	SUPT6H	166	Q7KZ85
EEEEEEMAEDIEDLD	UBE2Q2	141	Q8WVN8
AEPMAEEEEEEEDEE	PLPPR3	436	Q6T4P5
MPEEEDEDDEDGGEE	SUGP2	891	Q8IX01
DMDTDAPEEEEDEAD	ROBO1	1321	Q9Y6N7
DEEDDEEMEDEEAMA	ZNF526	241	Q8TF50
PEMEDEDEEDDSEDA	STRN4	301	Q9NRL3
QEMDDLELEDDEDDP	RWDD1	216	Q9H446
MIPSDEEEEDDEEEE	TUT7	841	Q5VYS8