Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionserine-type endopeptidase activity

PRSS47P TMPRSS13 PRSS38 PRSS27 HPN PRSS50 PRSS42P C1R CORIN TMPRSS5 TMPRSS7 PRSS48 F7

5.88e-151905713GO:0004252
GeneOntologyMolecularFunctionserine-type peptidase activity

PRSS47P TMPRSS13 PRSS38 PRSS27 HPN PRSS50 PRSS42P C1R CORIN TMPRSS5 TMPRSS7 PRSS48 F7

1.79e-142075713GO:0008236
GeneOntologyMolecularFunctionserine hydrolase activity

PRSS47P TMPRSS13 PRSS38 PRSS27 HPN PRSS50 PRSS42P C1R CORIN TMPRSS5 TMPRSS7 PRSS48 F7

2.44e-142125713GO:0017171
GeneOntologyMolecularFunctionendopeptidase activity

PRSS47P TMPRSS13 ADAMTS9 PRSS38 PRSS27 HPN PRSS50 PRSS42P C1R CORIN TMPRSS5 TMPRSS7 PRSS48 F7

1.24e-114305714GO:0004175
GeneOntologyMolecularFunctionG protein-coupled photoreceptor activity

OPN1MW2 OPN1MW3 OPN3 OPN1LW OPN1MW

4.65e-1015575GO:0008020
GeneOntologyMolecularFunctionphotoreceptor activity

OPN1MW2 OPN1MW3 OPN3 OPN1LW OPN1MW

9.55e-1017575GO:0009881
GeneOntologyMolecularFunctionpeptidase activity

PRSS47P TMPRSS13 ADAMTS9 PRSS38 PRSS27 HPN PRSS50 PRSS42P C1R CORIN TMPRSS5 TMPRSS7 PRSS48 F7

2.98e-096545714GO:0008233
GeneOntologyBiologicalProcessdetection of external stimulus

OPN1MW2 OPN1MW3 SEMA5B OPN3 HPN OPN1LW STRC OPN1MW STRCP1

7.61e-10173559GO:0009581
GeneOntologyBiologicalProcessdetection of abiotic stimulus

OPN1MW2 OPN1MW3 SEMA5B OPN3 HPN OPN1LW STRC OPN1MW STRCP1

8.43e-10175559GO:0009582
GeneOntologyBiologicalProcessdetection of visible light

OPN1MW2 OPN1MW3 SEMA5B OPN3 OPN1LW OPN1MW

8.87e-0957556GO:0009584
GeneOntologyBiologicalProcessdetection of light stimulus

OPN1MW2 OPN1MW3 SEMA5B OPN3 OPN1LW OPN1MW

5.56e-0877556GO:0009583
GeneOntologyBiologicalProcessphototransduction

OPN1MW2 OPN1MW3 OPN3 OPN1LW OPN1MW

2.91e-0753555GO:0007602
GeneOntologyBiologicalProcesscellular response to light stimulus

OPN1MW2 OPN1MW3 OPN3 OPN1LW OPN1MW

2.49e-05130555GO:0071482
GeneOntologyBiologicalProcessdetection of mechanical stimulus involved in sensory perception of sound

HPN STRC STRCP1

3.06e-0523553GO:0050910
GeneOntologyBiologicalProcessvisual perception

OPN1MW2 OPN1MW3 SEMA5B OPN1LW CDH23 OPN1MW

3.31e-05230556GO:0007601
GeneOntologyBiologicalProcesssensory perception of light stimulus

OPN1MW2 OPN1MW3 SEMA5B OPN1LW CDH23 OPN1MW

3.56e-05233556GO:0050953
GeneOntologyBiologicalProcessauditory receptor cell stereocilium organization

CDH23 STRC STRCP1

4.47e-0526553GO:0060088
GeneOntologyBiologicalProcessauditory receptor cell morphogenesis

CDH23 STRC STRCP1

7.65e-0531553GO:0002093
GeneOntologyBiologicalProcessdetection of stimulus

OPN1MW2 OPN1MW3 SEMA5B OPN3 HPN OPN1LW STRC OPN1MW STRCP1

1.13e-04722559GO:0051606
GeneOntologyBiologicalProcessregulation of cytokinesis

OPN1MW2 OPN1LW OPN1MW BIRC6

1.41e-0499554GO:0032465
GeneOntologyBiologicalProcessauditory receptor cell development

CDH23 STRC STRCP1

1.65e-0440553GO:0060117
GeneOntologyBiologicalProcesscellular response to radiation

OPN1MW2 OPN1MW3 OPN3 OPN1LW OPN1MW

1.66e-04194555GO:0071478
GeneOntologyBiologicalProcessprotein maturation

FUT10 RNF123 LMAN2L HPN C1R CORIN AASDHPPT F7

2.21e-04619558GO:0051604
GeneOntologyBiologicalProcessinner ear receptor cell stereocilium organization

CDH23 STRC STRCP1

3.82e-0453553GO:0060122
GeneOntologyBiologicalProcessinner ear morphogenesis

HPN CDH23 STRC STRCP1

3.89e-04129554GO:0042472
GeneOntologyBiologicalProcesspositive regulation of cytokinesis

OPN1MW2 OPN1LW OPN1MW

4.27e-0455553GO:0032467
GeneOntologyBiologicalProcessdetection of mechanical stimulus involved in sensory perception

HPN STRC STRCP1

4.74e-0457553GO:0050974
GeneOntologyBiologicalProcessresponse to light stimulus

OPN1MW2 OPN1MW3 SEMA5B OPN3 OPN1LW OPN1MW

5.23e-04382556GO:0009416
GeneOntologyBiologicalProcessregulation of excretion

CORIN PTGER3

5.34e-0413552GO:0044062
GeneOntologyBiologicalProcessphosphate ion transmembrane transport

SLC37A1 SLC20A2

7.17e-0415552GO:0035435
GeneOntologyBiologicalProcessear morphogenesis

HPN CDH23 STRC STRCP1

7.58e-04154554GO:0042471
GeneOntologyBiologicalProcessinner ear auditory receptor cell differentiation

CDH23 STRC STRCP1

7.62e-0467553GO:0042491
GeneOntologyBiologicalProcessinner ear receptor cell development

CDH23 STRC STRCP1

9.78e-0473553GO:0060119
GeneOntologyCellularComponentnon-motile cilium

OPN1MW2 OPN1MW3 OPN3 OPN1LW CDH23 STRC OPN1MW STRCP1

5.00e-08196568GO:0097730
GeneOntologyCellularComponentphotoreceptor disc membrane

OPN1MW2 OPN1MW3 OPN1LW OPN1MW

6.61e-0726564GO:0097381
GeneOntologyCellularComponentkinocilium

CDH23 STRC STRCP1

6.49e-0614563GO:0060091
GeneOntologyCellularComponent9+2 non-motile cilium

CDH23 STRC STRCP1

6.49e-0614563GO:0097732
GeneOntologyCellularComponentphotoreceptor outer segment

OPN1MW2 OPN1MW3 OPN3 OPN1LW OPN1MW

1.19e-05111565GO:0001750
GeneOntologyCellularComponentstereocilium tip

CDH23 STRC STRCP1

2.70e-0522563GO:0032426
GeneOntologyCellularComponentcluster of actin-based cell projections

MYO1C SLC20A2 CDH23 STRC PTGER3 STRCP1

2.87e-05223566GO:0098862
GeneOntologyCellularComponentstereocilium

MYO1C CDH23 STRC STRCP1

3.51e-0569564GO:0032420
GeneOntologyCellularComponentphotoreceptor cell cilium

OPN1MW2 OPN1MW3 OPN3 OPN1LW OPN1MW

3.52e-05139565GO:0097733
GeneOntologyCellularComponent9+0 non-motile cilium

OPN1MW2 OPN1MW3 OPN3 OPN1LW OPN1MW

5.56e-05153565GO:0097731
GeneOntologyCellularComponentstereocilium bundle

MYO1C CDH23 STRC STRCP1

5.98e-0579564GO:0032421
GeneOntologyCellularComponentactin-based cell projection

MYO1C PTPRH APBB1 CDH23 STRC STRCP1

9.74e-05278566GO:0098858
GeneOntologyCellularComponentcilium

OPN1MW2 OPN1MW3 PTCHD3 OPN3 OPN1LW CDH23 STRC OPN1MW STRCP1

5.90e-04898569GO:0005929
HumanPhenoBlue cone monochromacy

OPN1LW OPN1MW

6.01e-062132HP:0007939
HumanPhenoCone monochromacy

OPN1LW OPN1MW

6.01e-062132HP:0011517
HumanPhenoReduced OCT-measured foveal thickness

OPN1LW OPN1MW

1.80e-053132HP:0030619
HumanPhenoAbnormal OCT-measured foveal thickness

OPN1LW OPN1MW

3.60e-054132HP:0030617
HumanPhenoAbnormal foveal morphology on macular OCT

OPN1LW OPN1MW

1.67e-048132HP:0030613
HumanPhenoPendular nystagmus

OPN1LW OPN1MW DNMBP

1.73e-0445133HP:0012043
HumanPhenoEccentric visual fixation

OPN1LW OPN1MW

2.67e-0410132HP:0025549
HumanPhenoRed-green dyschromatopsia

OPN1LW OPN1MW

3.26e-0411132HP:0000642
HumanPhenoAnomalous trichromacy

OPN1LW OPN1MW

3.26e-0411132HP:0011519
HumanPhenoMonochromacy

OPN1LW OPN1MW

3.26e-0411132HP:0007803
MousePhenoabnormal hair cell physiology

MYO1C HPN CDH23 STRC STRCP1

2.26e-0749395MP:0003879
MousePhenoabnormal cochlear outer hair cell physiology

HPN CDH23 STRC STRCP1

1.01e-0628394MP:0004434
MousePhenoabnormal sensory neuron physiology

MYO1C HPN CDH23 STRC STRCP1

1.58e-0672395MP:0010055
MousePhenoabnormal somatic nervous system physiology

MYO1C HPN CDH23 STRC STRCP1

3.21e-0683395MP:0005423
MousePhenoabnormal cochlear hair cell physiology

HPN CDH23 STRC STRCP1

4.40e-0640394MP:0004432
MousePhenoabnormal electroretinogram waveform feature

OPN1MW2 OPN1MW3 OPN1LW CDH23 IRF3

1.07e-05106395MP:0012029
MousePhenodecreased b-wave amplitude

OPN1MW2 OPN1MW3 OPN1LW IRF3

7.74e-0582394MP:0012144
MousePhenoabnormal b-wave shape

OPN1MW2 OPN1MW3 OPN1LW IRF3

8.90e-0585394MP:0012035
MousePhenoabnormal b-wave amplitude

OPN1MW2 OPN1MW3 OPN1LW IRF3

8.90e-0585394MP:0012031
MousePhenoabsent distortion product otoacoustic emissions

CDH23 STRC STRCP1

1.99e-0441393MP:0004737
MousePhenoabnormal ear physiology

RNF123 MYO1C SLC20A2 HPN CDH23 STRC DNMBP STRCP1

5.03e-04684398MP:0003878
DomainPeptidase_S1A

TMPRSS13 PRSS38 PRSS27 HPN PRSS50 PRSS42P C1R CORIN TMPRSS5 TMPRSS7 PRSS48 F7

2.23e-161135212IPR001314
DomainTRYPSIN_DOM

TMPRSS13 PRSS38 PRSS27 HPN PRSS50 PRSS42P C1R CORIN TMPRSS5 TMPRSS7 PRSS48 F7

2.77e-161155212PS50240
DomainTryp_SPc

TMPRSS13 PRSS38 PRSS27 HPN PRSS50 PRSS42P C1R CORIN TMPRSS5 TMPRSS7 PRSS48 F7

3.43e-161175212SM00020
DomainTrypsin

TMPRSS13 PRSS38 PRSS27 HPN PRSS50 PRSS42P C1R CORIN TMPRSS5 TMPRSS7 PRSS48 F7

5.19e-161215212PF00089
DomainTrypsin_dom

TMPRSS13 PRSS38 PRSS27 HPN PRSS50 PRSS42P C1R CORIN TMPRSS5 TMPRSS7 PRSS48 F7

5.19e-161215212IPR001254
DomainPeptidase_S1_PA

TMPRSS13 PRSS38 PRSS27 HPN PRSS50 PRSS42P C1R CORIN TMPRSS5 TMPRSS7 PRSS48 F7

6.35e-161235212IPR009003
DomainTRYPSIN_HIS

TMPRSS13 PRSS38 PRSS27 HPN PRSS42P C1R CORIN TMPRSS5 TMPRSS7 PRSS48 F7

4.15e-151035211IPR018114
DomainTRYPSIN_SER

TMPRSS13 PRSS38 PRSS27 HPN PRSS42P C1R CORIN TMPRSS5 TMPRSS7 PRSS48 F7

5.75e-151065211PS00135
DomainTRYPSIN_HIS

TMPRSS13 PRSS38 PRSS27 HPN PRSS42P C1R CORIN TMPRSS5 TMPRSS7 PRSS48 F7

6.40e-151075211PS00134
DomainTRYPSIN_SER

TMPRSS13 PRSS38 PRSS27 HPN C1R CORIN TMPRSS5 TMPRSS7 PRSS48 F7

5.41e-14905210IPR033116
DomainSRCR_1

TMPRSS13 HPN CORIN TMPRSS5 CD163

8.64e-0926525PS00420
DomainSRCR_2

TMPRSS13 HPN CORIN TMPRSS5 CD163

8.64e-0926525PS50287
DomainSRCR-like_dom

TMPRSS13 HPN CORIN TMPRSS5 CD163

8.64e-0926525IPR017448
DomainSRCR

TMPRSS13 HPN CORIN TMPRSS5 CD163

1.06e-0827525IPR001190
DomainOPSIN

OPN1MW3 OPN3 OPN1LW OPN1MW

1.11e-0810524PS00238
DomainOpsin

OPN1MW3 OPN3 OPN1LW OPN1MW

1.74e-0811524IPR001760
DomainOpsin_red/grn

OPN1MW3 OPN1LW OPN1MW

2.04e-083523IPR000378
DomainSR

TMPRSS13 HPN CORIN CD163

6.47e-0725524SM00202
Domain-

TMPRSS13 HPN TMPRSS5 CD163

6.47e-07255243.10.250.10
DomainSRCR_2

TMPRSS13 CORIN TMPRSS5

7.07e-077523PF15494
DomainRetinal_BS

OPN1MW3 OPN3

2.11e-048522IPR027430
Domain-

TMPRSS13 CORIN TMPRSS7

2.84e-04465234.10.400.10
DomainLDLRA_1

TMPRSS13 CORIN TMPRSS7

3.22e-0448523PS01209
DomainLDLRA_2

TMPRSS13 CORIN TMPRSS7

3.43e-0449523PS50068
DomainLDrepeatLR_classA_rpt

TMPRSS13 CORIN TMPRSS7

3.43e-0449523IPR002172
DomainLDLa

TMPRSS13 CORIN TMPRSS7

3.43e-0449523SM00192
DomainGDS_CDC24_CS

ALS2 DNMBP

5.27e-0339522IPR001331
DomainLDLR_class-A_CS

CORIN TMPRSS7

5.54e-0340522IPR023415
DomainLdl_recept_a

CORIN TMPRSS7

6.97e-0345522PF00057
DomainCUB

C1R TMPRSS7

8.22e-0349522PF00431
DomainCUB

C1R TMPRSS7

8.55e-0350522SM00042
Domain-

C1R TMPRSS7

9.22e-03525222.60.120.290
DomainSushi

SUSD3 C1R

9.22e-0352522PF00084
DomainCUB

C1R TMPRSS7

9.57e-0353522PS01180
DomainCCP

SUSD3 C1R

9.92e-0354522SM00032
DomainSUSHI

SUSD3 C1R

1.06e-0256522PS50923
DomainSushi_SCR_CCP_dom

SUSD3 C1R

1.10e-0257522IPR000436
DomainCUB_dom

C1R TMPRSS7

1.10e-0257522IPR000859
PathwayREACTOME_OPSINS

OPN1MW2 OPN1MW3 OPN3 OPN1LW

1.04e-0810394MM15063
PathwayREACTOME_THE_RETINOID_CYCLE_IN_CONES_DAYLIGHT_VISION

OPN1MW2 OPN1MW3 OPN1LW

1.09e-068393MM14880
PathwayREACTOME_OPSINS

OPN3 OPN1LW OPN1MW

1.63e-069393M6285
PathwayWP_GPCRS_CLASS_A_RHODOPSINLIKE

OPN1MW2 OPN1MW3 OPN3 OPN1LW PTGER3

1.52e-04186395MM15994
PathwayREACTOME_THE_RETINOID_CYCLE_IN_CONES_DAYLIGHT_VISION

OPN1LW OPN1MW

1.55e-047392M27157
PathwayREACTOME_SENSORY_PROCESSING_OF_SOUND_BY_OUTER_HAIR_CELLS_OF_THE_COCHLEA

MYO1C CDH23 STRC

4.65e-0455393M41823
PathwayREACTOME_RETINOID_CYCLE_DISEASE_EVENTS

OPN1LW OPN1MW

5.71e-0413392M29612
PathwayREACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS

SEMA5B ADAMTS9 MUC6

8.66e-0468393M27303
Pubmed

Human L- and M-opsins restore M-cone function in a mouse model for human blue cone monochromacy.

OPN1MW2 OPN1MW3 OPN1LW OPN1MW

6.96e-12458429386880
Pubmed

Molecular genetics of human color vision: the genes encoding blue, green, and red pigments.

OPN1MW2 OPN1MW3 OPN1LW OPN1MW

3.48e-1155842937147
Pubmed

Genetic and physical mapping of a gene encoding a methyl CpG binding protein, Mecp2, to the mouse X chromosome.

OPN1MW2 CDR1 OPN1MW3 OPN1LW

2.43e-1075848001979
Pubmed

Molecular determinants of human red/green color discrimination.

OPN1MW2 OPN1LW OPN1MW

4.40e-0935838185948
Pubmed

X-linked cone dystrophy caused by mutation of the red and green cone opsins.

OPN1MW2 OPN1LW OPN1MW

4.40e-09358320579627
Pubmed

Expression of red/green-cone opsin mutants K82E, P187S, M273K result in unique pathobiological perturbations to cone structure and function.

OPN1MW2 OPN1MW3 OPN1LW

4.40e-09358338410159
Pubmed

Chloride-dependent spectral tuning mechanism of L-group cone visual pigments.

OPN1MW2 OPN1MW3 OPN1LW

4.40e-09358323350963
Pubmed

Distinct contributions of rod, cone, and melanopsin photoreceptors to encoding irradiance.

OPN1MW2 OPN1MW3 OPN1LW

4.40e-09358320471354
Pubmed

Multiple hypothalamic cell populations encoding distinct visual information.

OPN1MW2 OPN1MW3 OPN1LW

4.40e-09358321224225
Pubmed

Gene-based Therapy in a Mouse Model of Blue Cone Monochromacy.

OPN1MW2 OPN1MW3 OPN1LW

4.40e-09358328751656
Pubmed

Circadian Regulation of the Rod Contribution to Mesopic Vision in Mice.

OPN1MW2 OPN1MW3 OPN1LW

4.40e-09358336216501
Pubmed

Rescue of M-cone Function in Aged Opn1mw-/- Mice, a Model for Late-Stage Blue Cone Monochromacy.

OPN1MW2 OPN1MW3 OPN1LW

4.40e-09358331469404
Pubmed

The molecular genetics and evolution of red and green color vision in vertebrates.

OPN1MW2 OPN1MW3 OPN1LW

4.40e-09358311545071
Pubmed

Mechanisms of spectral tuning in the mouse green cone pigment.

OPN1MW2 OPN1MW3 OPN1LW

4.40e-0935839238068
Pubmed

Emergence of novel color vision in mice engineered to express a human cone photopigment.

OPN1MW2 OPN1MW3 OPN1LW

4.40e-09358317379811
Pubmed

Spectral tuning of a circadian photopigment in a subterranean 'blind' mammal (Spalax ehrenbergi).

OPN1MW2 OPN1MW3 OPN1LW

4.40e-09358310567724
Pubmed

Extensive cone-dependent spectral opponency within a discrete zone of the lateral geniculate nucleus supporting mouse color vision.

OPN1MW2 OPN1MW3 OPN1LW

4.40e-09358334111401
Pubmed

Co-expression of murine opsins facilitates identifying the site of cone adaptation.

OPN1MW2 OPN1MW3 OPN1LW

4.40e-09358312511072
Pubmed

The Pem homeobox gene is X-linked and exclusively expressed in extraembryonic tissues during early murine development.

OPN1MW2 OPN1MW3 OPN1LW

4.40e-0935837958444
Pubmed

Genetically engineered mice with an additional class of cone photoreceptors: implications for the evolution of color vision.

OPN1MW2 OPN1MW3 OPN1LW

4.40e-09358314500905
Pubmed

Melanopsin-driven increases in maintained activity enhance thalamic visual response reliability across a simulated dawn.

OPN1MW2 OPN1MW3 OPN1LW

1.76e-08458326438865
Pubmed

Light/dark translocation of alphatransducin in mouse photoreceptor cells expressing G90D mutant opsin.

OPN1MW2 OPN1MW3 OPN1LW

1.76e-08458317249565
Pubmed

Structural and functional rescue of cones carrying the most common cone opsin C203R missense mutation.

OPN1MW2 OPN1MW3 OPN1LW

1.76e-08458338060327
Pubmed

Contribution of M-opsin-based color vision to refractive development in mice.

OPN1MW2 OPN1MW3 OPN1LW

1.76e-08458334126082
Pubmed

Physiological features of the S- and M-cone photoreceptors of wild-type mice from single-cell recordings.

OPN1MW2 OPN1MW3 OPN1LW

1.76e-08458316567464
Pubmed

Visual responses in the dorsal lateral geniculate nucleus at early stages of retinal degeneration in rd1 PDE6β mice.

OPN1MW2 OPN1MW3 OPN1LW

1.76e-08458331461375
Pubmed

S-opsin knockout mice with the endogenous M-opsin gene replaced by an L-opsin variant.

OPN1MW2 OPN1MW3 OPN1LW

1.76e-08458324801621
Pubmed

Murine and bovine blue cone pigment genes: cloning and characterization of two new members of the S family of visual pigments.

OPN1MW2 OPN1MW3 OPN1LW

1.76e-0845838088841
Pubmed

Modulation of Fast Narrowband Oscillations in the Mouse Retina and dLGN According to Background Light Intensity.

OPN1MW2 OPN1MW3 OPN1LW

1.76e-08458328103478
Pubmed

Melanopsin Contributions to the Representation of Images in the Early Visual System.

OPN1MW2 OPN1MW3 OPN1LW

1.76e-08458328528909
Pubmed

Molecular biology of the visual pigments.

OPN1MW2 OPN1LW OPN1MW

1.76e-0845833303660
Pubmed

Cones Support Alignment to an Inconsistent World by Suppressing Mouse Circadian Responses to the Blue Colors Associated with Twilight.

OPN1MW2 OPN1MW3 OPN1LW

1.76e-08458331846668
Pubmed

Melanopsin-driven light adaptation in mouse vision.

OPN1MW2 OPN1MW3 OPN1LW

1.76e-08458325308073
Pubmed

Noncoding Mutations in a Thyroid Hormone Receptor Gene That Impair Cone Photoreceptor Function.

OPN1MW2 OPN1MW3 OPN1LW

4.39e-08558336631163
Pubmed

Using Silent Substitution to Track the Mesopic Transition From Rod- to Cone-Based Vision in Mice.

OPN1MW2 OPN1MW3 OPN1LW

4.39e-08558326818794
Pubmed

A common integration locus in type B retrovirus-induced thymic lymphomas.

OPN1MW2 OPN1MW3 OPN1LW

4.39e-0855831333116
Pubmed

Melanopsin-based brightness discrimination in mice and humans.

OPN1MW2 OPN1MW3 OPN1LW

4.39e-08558322633808
Pubmed

The murine cone photoreceptor: a single cone type expresses both S and M opsins with retinal spatial patterning.

OPN1MW2 OPN1MW3 OPN1LW

4.39e-08558311055434
Pubmed

A distinct contribution of short-wavelength-sensitive cones to light-evoked activity in the mouse pretectal olivary nucleus.

OPN1MW2 OPN1MW3 OPN1LW

4.39e-08558322090509
Pubmed

Comparative sequence analysis of the MECP2-locus in human and mouse reveals new transcribed regions.

OPN1MW2 OPN1MW3 OPN1LW

4.39e-08558310723722
Pubmed

Enhancer/promoter activities of the long/middle wavelength-sensitive opsins of vertebrates mediated by thyroid hormone receptor β2 and COUP-TFII.

OPN1MW2 OPN1MW3 OPN1LW

4.39e-08558324058409
Pubmed

Variations in photoreceptor throughput to mouse visual cortex and the unique effects on tuning.

OPN1MW2 OPN1MW3 OPN1LW

4.39e-08558334099749
Pubmed

Peripherin-2 differentially interacts with cone opsins in outer segments of cone photoreceptors.

OPN1MW2 OPN1MW3 OPN1LW

4.39e-08558327033727
Pubmed

An unusually powerful mode of low-frequency sound interference due to defective hair bundles of the auditory outer hair cells.

CDH23 STRC STRCP1

4.39e-08558324920589
Pubmed

Functional comparison of rod and cone Gα(t) on the regulation of light sensitivity.

OPN1MW2 OPN1MW3 OPN1LW

8.77e-08658323288843
Pubmed

Reduced levels of dystrophin associated proteins in the brains of mice deficient for Dp71.

OPN1MW2 OPN1MW3 OPN1LW

8.77e-0865838872469
Pubmed

A thyroid hormone receptor that is required for the development of green cone photoreceptors.

OPN1MW2 OPN1MW3 OPN1LW

8.77e-08658311138006
Pubmed

Impaired cytokine signaling in mice lacking the IL-1 receptor-associated kinase.

OPN1MW2 OPN1MW3 OPN1LW

8.77e-08658310395695
Pubmed

Transient expression of thyroid hormone nuclear receptor TRbeta2 sets S opsin patterning during cone photoreceptor genesis.

OPN1MW2 OPN1MW3 OPN1LW

8.77e-08658317436273
Pubmed

Telomere-related markers for the pseudoautosomal region of the mouse genome.

OPN1MW2 OPN1MW3 OPN1LW

8.77e-0865831549575
Pubmed

Characterization of cDNAs encoding the murine interleukin 2 receptor (IL-2R) gamma chain: chromosomal mapping and tissue specificity of IL-2R gamma chain expression.

OPN1MW2 OPN1MW3 OPN1LW

1.53e-0775838378320
Pubmed

Retarded developmental expression and patterning of retinal cone opsins in hypothyroid mice.

OPN1MW2 OPN1MW3 OPN1LW

1.53e-07758318974269
Pubmed

Rod Photoreceptor Activation Alone Defines the Release of Dopamine in the Retina.

OPN1MW2 OPN1MW3 OPN1LW

1.53e-07758330799247
Pubmed

Activation of the blue opsin gene in cone photoreceptor development by retinoid-related orphan receptor beta.

OPN1MW2 OPN1MW3 OPN1LW

1.53e-07758316574740
Pubmed

Rods progressively escape saturation to drive visual responses in daylight conditions.

OPN1MW2 OPN1MW3 OPN1LW

1.53e-07758329180667
Pubmed

NeuroD1 regulates expression of thyroid hormone receptor 2 and cone opsins in the developing mouse retina.

OPN1MW2 OPN1MW3 OPN1LW

1.53e-07758318199774
Pubmed

Mapping of the murine tbl1 gene reveals a new rearrangement between mouse and human X Chromosomes.

OPN1MW2 OPN1MW3 OPN1LW

1.53e-0775839880679
Pubmed

Cloning and distribution of myosin 3B in the mouse retina: differential distribution in cone outer segments.

OPN1MW2 OPN1MW3 OPN1LW

1.53e-07758319332056
Pubmed

X-chromosome gene order in different Mus species crosses.

OPN1MW2 OPN1MW3 OPN1LW

2.45e-0785833416629
Pubmed

The retinitis pigmentosa GTPase regulator (RPGR)- interacting protein: subserving RPGR function and participating in disk morphogenesis.

OPN1MW2 OPN1MW3 OPN1LW

2.45e-07858312651948
Pubmed

Transcriptional profiling of murine retinas undergoing semi-synchronous cone photoreceptor differentiation.

OPN1MW2 OPN1MW3 OPN1LW

2.45e-07858331163126
Pubmed

Type 3 deiodinase, a thyroid-hormone-inactivating enzyme, controls survival and maturation of cone photoreceptors.

OPN1MW2 OPN1MW3 OPN1LW

2.45e-07858320203194
Pubmed

Tubby is required for trafficking G protein-coupled receptors to neuronal cilia.

OPN1MW2 OPN1MW3 OPN1LW

2.45e-07858323351594
Pubmed

Localization of the mdx mutation within the mouse dystrophin gene.

OPN1MW2 OPN1MW3 OPN1LW

2.45e-0785832903046
Pubmed

A retinitis pigmentosa GTPase regulator (RPGR)-deficient mouse model for X-linked retinitis pigmentosa (RP3).

OPN1MW2 OPN1MW3 OPN1LW

2.45e-07858310725384
Pubmed

Retinoid X receptor (gamma) is necessary to establish the S-opsin gradient in cone photoreceptors of the developing mouse retina.

OPN1MW2 OPN1MW3 OPN1LW

2.45e-07858316043864
Pubmed

Stereocilin connects outer hair cell stereocilia to one another and to the tectorial membrane.

CDH23 STRC STRCP1

2.45e-07858321165971
Pubmed

Nr2e3 functional domain ablation by CRISPR-Cas9D10A identifies a new isoform and generates retinitis pigmentosa and enhanced S-cone syndrome models.

OPN1MW2 OPN1MW3 OPN1LW

2.45e-07858333007388
Pubmed

Genetic mapping on the mouse X chromosome of human cDNA clones for the fragile X and Hunter syndromes.

OPN1MW2 OPN1MW3 OPN1LW

2.45e-0785831572654
Pubmed

Linkage of amelogenin (Amel) to the distal portion of the mouse X chromosome.

OPN1MW2 OPN1MW3 OPN1LW

2.45e-0785831675194
Pubmed

Two transcription factors can direct three photoreceptor outcomes from rod precursor cells in mouse retinal development.

OPN1MW2 OPN1MW3 OPN1LW

2.45e-07858321813673
Pubmed

Retinal dystrophy resulting from ablation of RXR alpha in the mouse retinal pigment epithelium.

OPN1MW2 OPN1MW3 OPN1LW

3.67e-07958314742273
Pubmed

A visual circuit uses complementary mechanisms to support transient and sustained pupil constriction.

OPN1MW2 OPN1MW3 OPN1LW

3.67e-07958327669145
Pubmed

Close linkage of the murine locus bare patches to the X-linked visual pigment gene: implications for mapping human X-linked dominant chondrodysplasia punctata.

OPN1MW2 OPN1MW3 OPN1LW

3.67e-0795831973136
Pubmed

Feedback induction of a photoreceptor-specific isoform of retinoid-related orphan nuclear receptor β by the rod transcription factor NRL.

OPN1MW2 OPN1MW3 OPN1LW

3.67e-07958325296752
Pubmed

Comparative mapping of the actin-binding protein 280 genes in human and mouse.

OPN1MW2 OPN1MW3 OPN1LW

3.67e-0795838088838
Pubmed

Distinct functions of photoreceptor cell-specific nuclear receptor, thyroid hormone receptor beta2 and CRX in one photoreceptor development.

OPN1MW2 OPN1MW3 OPN1LW

3.67e-07958312407160
Pubmed

ZBED4, a cone and Müller cell protein in human retina, has a different cellular expression in mouse.

OPN1MW2 OPN1MW3 OPN1LW

3.67e-07958321850176
Pubmed

Top2b is involved in the formation of outer segment and synapse during late-stage photoreceptor differentiation by controlling key genes of photoreceptor transcriptional regulatory network.

OPN1MW2 OPN1MW3 OPN1LW

3.67e-07958328370415
Pubmed

IFT20 is required for opsin trafficking and photoreceptor outer segment development.

OPN1MW2 OPN1MW3 OPN1LW

3.67e-07958321307337
Pubmed

Multilocus molecular mapping of the mouse X chromosome.

OPN1MW2 OPN1MW3 OPN1LW

3.67e-0795832906327
Pubmed

Vax2 regulates retinoic acid distribution and cone opsin expression in the vertebrate eye.

OPN1MW2 OPN1MW3 OPN1LW

5.24e-071058321148184
Pubmed

Fam151b, the mouse homologue of C.elegans menorin gene, is essential for retinal function.

OPN1MW2 OPN1MW3 OPN1LW

5.24e-071058331949211
Pubmed

Comparative mapping on the mouse and human X chromosomes of a human cDNA clone encoding the vasopressin renal-type receptor (AVP2R).

OPN1MW2 OPN1MW3 OPN1LW

5.24e-07105838449515
Pubmed

Mapping of ornithine aminotransferase gene sequences to mouse chromosomes 7, X, and 3.

OPN1MW2 OPN1MW3 OPN1LW

5.24e-07105831349842
Pubmed

The nanophthalmos protein TMEM98 inhibits MYRF self-cleavage and is required for eye size specification.

OPN1MW2 OPN1MW3 OPN1LW

5.24e-071058332236127
Pubmed

Physical mapping of the loci Gabra3, DXPas8, CamL1, and Rsvp in a region of the mouse X chromosome homologous to human Xq28.

OPN1MW2 OPN1MW3 OPN1LW

5.24e-07105831684949
Pubmed

Mapping of the phosphorylase kinase alpha subunit gene on the mouse X chromosome.

OPN1MW2 OPN1MW3 OPN1LW

5.24e-07105831973380
Pubmed

Cyclophilin-related protein RanBP2 acts as chaperone for red/green opsin.

OPN1MW2 OPN1LW OPN1MW

5.24e-07105838857542
Pubmed

Linkage of a gene for neural cell adhesion molecule, L1 (CamL1) to the Rsvp region of the mouse X chromosome.

OPN1MW2 OPN1MW3 OPN1LW

5.24e-07105831964443
Pubmed

Otogelin, otogelin-like, and stereocilin form links connecting outer hair cell stereocilia to each other and the tectorial membrane.

CDH23 STRC STRCP1

7.19e-071158331776257
Pubmed

Mannose supplements induce embryonic lethality and blindness in phosphomannose isomerase hypomorphic mice.

OPN1MW2 OPN1MW3 OPN1LW

7.19e-071158324421398
Pubmed

Physical linkage of the A-raf-1, properdin, synapsin I, and TIMP genes on the human and mouse X chromosomes.

OPN1MW2 OPN1MW3 OPN1LW

7.19e-07115831572636
Pubmed

Mapping of the glycine receptor alpha 2-subunit gene and the GABAA alpha 3-subunit gene on the mouse X chromosome.

OPN1MW2 OPN1MW3 OPN1LW

9.58e-07125831679744
Pubmed

The spatial patterning of mouse cone opsin expression is regulated by bone morphogenetic protein signaling through downstream effector COUP-TF nuclear receptors.

OPN1MW2 OPN1MW3 OPN1LW

9.58e-071258319812316
Pubmed

MAP4K4 is involved in the neuronal development of retinal photoreceptors.

OPN1MW2 OPN1MW3 OPN1LW

9.58e-071258337290629
Pubmed

Genetic and physical mapping of the biglycan gene on the mouse X chromosome.

OPN1MW2 OPN1MW3 OPN1LW

9.58e-07125838093671
Pubmed

The construction of human somatic cell hybrids containing portions of the mouse X chromosome and their use to generate DNA probes via interspersed repetitive sequence polymerase chain reaction.

OPN1MW2 OPN1MW3 OPN1LW

9.58e-07125831916827
Pubmed

Chromosomal localization of GABAA receptor subunit genes: relationship to human genetic disease.

OPN1MW2 OPN1MW3 OPN1LW

9.58e-07125832561974
Pubmed

G protein-coupled receptors participate in cytokinesis.

OPN1MW2 OPN1LW OPN1MW

1.24e-061358322888021
InteractionTMPRSS6 interactions

HPN CORIN TMPRSS7 F7

8.85e-0910534int:TMPRSS6
InteractionCORIN interactions

CORIN TMPRSS7 F7

3.72e-0612533int:CORIN
InteractionHABP2 interactions

CORIN TMPRSS7 F7

1.36e-0518533int:HABP2
InteractionF7 interactions

HPN CORIN F7

3.34e-0524533int:F7
CytobandEnsembl 112 genes in cytogenetic band chrXq28

OPN1MW2 OPN1MW3 OPN1LW OPN1MW

1.57e-04213584chrXq28
Cytoband15q15.3

STRC STRCP1

4.62e-042558215q15.3
Cytoband9q22.31

PRSS47P SUSD3

5.40e-04275829q22.31
CytobandEnsembl 112 genes in cytogenetic band chr3p21

RNF123 PARP3 PRSS50 PRSS42P

6.97e-04316584chr3p21
Cytoband15q24.1

TMEM202 ISLR2

8.57e-043458215q24.1
CytobandXq28

OPN1MW2 OPN1LW OPN1MW

1.46e-03176583Xq28
Cytoband1p36.13

PADI4 SLC66A1

2.31e-03565821p36.13
Cytoband3p21.31

PRSS50 PRSS42P

7.17e-031005823p21.31
GeneFamilyProteases, serine

PRSS47P TMPRSS13 PRSS38 PRSS27 HPN PRSS50 PRSS42P CORIN TMPRSS5 TMPRSS7 PRSS48

4.44e-18634611738
GeneFamilyOpsin receptors

OPN1MW2 OPN1MW3 OPN3 OPN1LW OPN1MW

3.89e-1111465215
ToppCell367C-Lymphocytic-NK_cells-NK_cell_B1|367C / Donor, Lineage, Cell class and subclass (all cells)

RNF123 LMAN2L ACSS1 IRF3 AASDHPPT SLC66A1

5.97e-08161576f470b662566131dfe69a2fd01186ac8491196396
ToppCell367C-Lymphocytic-NK_cells-NK_cell_B1|NK_cells / Donor, Lineage, Cell class and subclass (all cells)

RNF123 LMAN2L IRF3 AASDHPPT SLC66A1

4.46e-061905752434b8ad2976eab7d9147012c28454ab29670709
ToppCell367C-Lymphocytic-NK_cells-NK_cell_B1|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

RNF123 LMAN2L ACSS1 AASDHPPT SLC66A1

4.58e-0619157539ef8e1d7cc3ebb11717e8a55501515e3b72b177
Drugbenzamidine

TMPRSS13 PRSS27 HPN CORIN AASDHPPT F7

1.46e-06147556CID000002332
DrugPhpc-1,2

OPN1LW OPN1MW

5.70e-055552CID000173570
Drug14-fluororetinal

OPN1LW OPN1MW

5.70e-055552CID006438634
Drug10,20-methanoretinal

OPN1LW OPN1MW

5.70e-055552CID006438558
Drugtrans-retinoyl chloromethane

OPN1LW OPN1MW

5.70e-055552CID006439860
Drug9,11-dcfr

OPN1LW OPN1MW

5.70e-055552CID006443659
DrugAC1Q5QHD

CDR1 CPAMD8

5.70e-055552CID000133943
DrugCoagulation factor VIIa

HPN F7

8.54e-056552DB00036
Drug3-hydroxyretinal

OPN1LW OPN1MW

8.54e-056552CID000151436
Drug7,8-Dhr

OPN1LW OPN1MW

8.54e-056552CID006443426
DrugAC1NTD7Z

OPN1LW OPN1MW

8.54e-056552CID005378594
Drug5,6-epoxy-3-dehydroretinal

OPN1LW OPN1MW

8.54e-056552CID006449988
Diseaseblue cone monochromacy (implicated_via_orthology)

OPN1MW2 OPN1MW3 OPN1LW OPN1MW

9.27e-124534DOID:0050679 (implicated_via_orthology)
DiseaseBORNHOLM EYE DISEASE

OPN1LW OPN1MW

3.17e-062532C3159311
DiseaseAchromatopsia incomplete, X-linked

OPN1LW OPN1MW

3.17e-062532C2931753
Diseaseautosomal recessive nonsyndromic deafness 16 (implicated_via_orthology)

STRC STRCP1

3.17e-062532DOID:0110471 (implicated_via_orthology)
DiseaseCone monochromatism

OPN1LW OPN1MW

3.17e-062532C0339537
DiseaseBLUE CONE MONOCHROMACY

OPN1LW OPN1MW

3.17e-062532303700
DiseaseRed-green dyschromatopsia

OPN1LW OPN1MW

3.17e-062532cv:C0155016
DiseaseCone monochromatism

OPN1LW OPN1MW

3.17e-062532cv:C0339537
Diseaseblue cone monochromacy (is_implicated_in)

OPN1LW OPN1MW

3.17e-062532DOID:0050679 (is_implicated_in)
Diseasetyrosine-protein phosphatase non-receptor type 4 measurement

ACSS1 C1R

1.13e-049532EFO_0802172
Diseaseadseverin measurement

C1R DNMBP

1.41e-0410532EFO_0801358
Diseasebrain cortex volume measurement

SEMA5B LINC00574

2.44e-0413532EFO_0010287
DiseaseCone-Rod Dystrophy 2

OPN1LW OPN1MW

1.25e-0329532C3489532
Diseaseasthma (implicated_via_orthology)

PTGER3 F7

1.81e-0335532DOID:2841 (implicated_via_orthology)
Diseaseasparagine measurement

CPAMD8 PTGER3

2.48e-0341532EFO_0009766
Diseaseselective IgA deficiency disease

CPAMD8 CDH23

3.11e-0346532EFO_1001929
Diseasefolic acid measurement

TMPRSS13 PRSS38

3.11e-0346532EFO_0005111

Protein segments in the cluster

PeptideGeneStartEntry
RCTLVDTWWQTETGG

ACSS1

436

Q9NUB1
GVRWAFSCGTWLPSR

AASDHPPT

16

Q9NRN7
CGGERWWGQFLSNVL

BIRC6

2086

Q9NR09
SISREIWAWGTGCQL

ALS2

166

Q96Q42
IWAWGTGCQLGLITT

ALS2

171

Q96Q42
DGIPTAGWLQGRSCW

DNMBP

96

Q6XZF7
TGGLRWEVHCWPSGT

CCDC142

36

Q17RM4
GWTVRRGVQSLWGSL

APBB1

686

O00213
DRWVATGIVSWGIGC

C1R

666

P00736
VAWLLVLISGCWGQV

CDH23

11

Q9H251
IGWKTWIFSGRCGLT

CDR1

201

P51861
GCGLVWLQAWAASTR

ISLR2

186

Q6UXK2
CGITGLWSLAIISWE

OPN1LW

136

P04000
CGITGLWSLAIISWE

OPN1MW3

136

P0DN78
CGITGLWSLAIISWE

OPN1MW2

136

P0DN77
TCWNRWGRVGEVGQS

PARP3

96

Q9Y6F1
ICLWSWRQTWGGRGS

LRWD1

521

Q9UFC0
WRQTWGGRGSQSTVA

LRWD1

526

Q9UFC0
RAVKDQRTWTWGPCG

PADI4

131

Q9UM07
RGVLLWGWRSSVDNC

MUC6

646

Q6W4X9
SLWFLLGWIGGDSCN

SLC66A1

71

Q6ZP29
VQWPGTWCFISTGRG

PTGER3

201

P43115
GPLGSWQQWRRCLSA

LMAN2L

6

Q9H0V9
SWLQIGIVSWGRGCS

PRSS38

256

A1L453
SLWALGNIGSSNWGL

RICTOR

926

Q6R327
TPRWRLCGIVSWGTG

HPN

366

P05981
CGITGLWSLAIISWE

OPN1MW

136

P04001
SCLRNGWVWDTVGCV

OPN3

101

Q9H1Y3
LGSLIAGYWVSTCWG

SLC37A1

206

P57057
WRVGNWGSCSVSCGV

ADAMTS9

1681

Q9P2N4
WWSPLTGETGRLGQC

FUT10

86

Q6P4F1
RTFWISWRGGLIQVG

CPAMD8

1036

Q8IZJ3
TAGAVRWWTCRGGHT

CPNE7

176

Q9UBL6
RWWTCRGGHTQGWQI

CPNE7

181

Q9UBL6
ADAGVSLVSGRWCAW

LINC00574

31

Q9H8X3
GRQWLVGSCEITNWL

CRYBG2

1496

Q8N1P7
GRWTLFGLTSWGSVC

CORIN

996

Q9Y5Q5
RVEIWHGGSWGTVCD

CD163

941

Q86VB7
GVGICTGLWVWGRRV

SLC20A2

541

Q08357
GLLSRTFQWLGWQVG

PTCHD3

121

Q3KNS1
SCLGGGLALWRAGQW

IRF3

266

Q14653
GLLTCTWKGSIAEWS

SUSD3

71

Q96L08
WYLTGIVSWGQGCAT

F7

416

P08709
AWVLVGLASWGLDCR

PRSS47P

286

A8MTI9
GLSRWAVLWLGACGV

TAP1

61

Q03518
GWGWGNTQSLSGECR

RUSC1-AS1

66

Q66K80
WPWLAGQCRISRGGN

STRC

551

Q7RTU9
WGVLSTLGQIDGWST

STRC

1551

Q7RTU9
NRWYLAGVTSWGTGC

TMPRSS13

521

Q9BYE2
GQRVRSGEKCWVTGW

TMPRSS7

721

Q7RTY8
WLQAGVISWGEGCAR

PRSS27

241

Q9BQR3
TNWILVRLWRGCGFG

RNF123

966

Q5XPI4
GWKICREGNGVSVSW

STARD5

26

Q9NSY2
TWRLVGVVSWGRGCA

TMPRSS5

416

Q9H3S3
GRTRCWVTGWGKTPE

PRSS42P

196

Q7Z5A4
LRCGWTVGGWLLSLV

SEMA5B

26

Q9P283
VWIQTGVVSWGLECG

PRSS48

231

Q7RTY5
WPWLAGQCRISRGGN

STRCP1

551

A6NGW2
TGLGWLFSSWILNRG

TMEM202

131

A6NGA9
TWYLVGLVSWGAGCQ

PRSS50

321

Q9UI38
WGNLVLLGLCSWTGA

PTPRH

11

Q9HD43
AICIQSWWRGTLGRR

MYO1C

761

O00159