Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	spliceosomal complex	DDX23 CACTIN SRRM2 ZRSR2	2.42e-04	215	30	4	GO:0005681
GeneOntologyCellularComponent	catalytic step 2 spliceosome	DDX23 CACTIN SRRM2	3.59e-04	97	30	3	GO:0071013
Domain	Myb_DNA-binding	MIDEAS TERF2	1.25e-03	35	28	2	PF00249
Domain	RNA_helicase_DEAD_Q_motif	DDX23 DDX50	1.40e-03	37	28	2	IPR014014
Domain	Q_MOTIF	DDX23 DDX50	1.40e-03	37	28	2	PS51195
Domain	MYB_LIKE	MIDEAS TERF2	1.47e-03	38	28	2	PS50090
Domain	SANT	MIDEAS TERF2	2.54e-03	50	28	2	SM00717
Domain	SANT/Myb	MIDEAS TERF2	2.74e-03	52	28	2	IPR001005
Domain	DEAD	DDX23 DDX50	5.33e-03	73	28	2	PF00270
Domain	DEAD/DEAH_box_helicase_dom	DDX23 DDX50	5.33e-03	73	28	2	IPR011545
Domain	Helicase_C	DDX23 DDX50	1.12e-02	107	28	2	PF00271
Domain	HELICc	DDX23 DDX50	1.12e-02	107	28	2	SM00490
Domain	Helicase_C	DDX23 DDX50	1.14e-02	108	28	2	IPR001650
Domain	HELICASE_CTER	DDX23 DDX50	1.16e-02	109	28	2	PS51194
Domain	HELICASE_ATP_BIND_1	DDX23 DDX50	1.16e-02	109	28	2	PS51192
Domain	DEXDc	DDX23 DDX50	1.16e-02	109	28	2	SM00487
Domain	Helicase_ATP-bd	DDX23 DDX50	1.18e-02	110	28	2	IPR014001
Pathway	REACTOME_MRNA_SPLICING	DDX23 CACTIN SRRM2 ZRSR2	1.05e-04	201	18	4	MM15411
Pathway	REACTOME_MRNA_SPLICING	DDX23 CACTIN SRRM2 ZRSR2	1.29e-04	212	18	4	M14033
Pathway	REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA	DDX23 CACTIN SRRM2 ZRSR2	3.59e-04	277	18	4	MM15414
Pathway	REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA	DDX23 CACTIN SRRM2 ZRSR2	3.90e-04	283	18	4	M13087
Pathway	WP_SARSCOV2_MITOCHONDRIAL_CHRONIC_OXIDATIVE_STRESS_AND_ENDOTHELIAL_DYSFUNCTION	TOMM70 TERF2	5.30e-04	27	18	2	M45548
Pubmed	The histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain.	SCAF1 DIMT1 LSM14B DDX50 TERF2 FXR2 ZNF574	6.95e-08	417	31	7	36537216
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	FBRSL1 SCAF1 CACTIN DIMT1 SRRM2 FXR2 ADCY6 ZNF574 ZNF646	3.72e-07	1116	31	9	31753913
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	FBRSL1 DDX23 CACTIN DIMT1 LSM14B DDX50 SRRM2 FXR2	3.99e-07	807	31	8	22681889
Pubmed	Human cactin interacts with DHX8 and SRRM2 to assure efficient pre-mRNA splicing and sister chromatid cohesion.	CACTIN SRRM2	2.31e-06	3	31	2	28062851
Pubmed	R2TP/Prefoldin-like component RUVBL1/RUVBL2 directly interacts with ZNHIT2 to regulate assembly of U5 small nuclear ribonucleoprotein.	DDX23 SCAF1 CACTIN DDX50 SRRM2	6.53e-06	300	31	5	28561026
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	DDX23 SCAF1 CACTIN DDX50 SRRM2 MIDEAS TERF2 RFWD3	1.32e-05	1294	31	8	30804502
Pubmed	SR protein kinases promote splicing of nonconsensus introns.	SCAF1 DDX50 SRRM2 FXR2 PNMA8B	1.59e-05	361	31	5	26167880
Pubmed	TRIM65 regulates microRNA activity by ubiquitination of TNRC6.	DIMT1 LSM14B DDX50 FXR2 ZNF574	1.66e-05	364	31	5	24778252
Pubmed	WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage.	DDX23 DDX50 MIDEAS TERF2 FXR2	2.43e-05	394	31	5	27248496
Pubmed	RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.	DDX23 DIMT1 LSM14B DDX50 SRRM2 FXR2	3.46e-05	713	31	6	29802200
Pubmed	Characterizing ZC3H18, a Multi-domain Protein at the Interface of RNA Production and Destruction Decisions.	DDX23 DIMT1 LSM14B DDX50 SRRM2 FXR2	3.97e-05	731	31	6	29298432
Pubmed	Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.	DDX23 CACTIN SRRM2	5.03e-05	80	31	3	11991638
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	SCAF1 CACTIN SORBS2 SRRM2 TERF2 ADCY6	5.46e-05	774	31	6	15302935
Pubmed	TRF2-mediated telomere protection is dispensable in pluripotent stem cells.	TERF2 RFWD3	6.95e-05	14	31	2	33239785
Pubmed	Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	ZFYVE26 SRRM2 ZNF646	1.10e-04	104	31	3	9205841
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	DDX23 SCAF1 CACTIN DIMT1 DDX50 SRRM2 FXR2	1.31e-04	1318	31	7	30463901
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	DDX23 SCAF1 CACTIN LSM14B MIDEAS FXR2 ZNF574	1.67e-04	1371	31	7	36244648
Pubmed	TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1.	DDX23 CACTIN DIMT1 DDX50 SRRM2 FXR2	1.67e-04	949	31	6	36574265
Pubmed	WWP2 ubiquitylates RNA polymerase II for DNA-PK-dependent transcription arrest and repair at DNA breaks.	LSM14B DDX50 SRRM2 MIDEAS FXR2	1.98e-04	615	31	5	31048545
Pubmed	ZBTB2 protein is a new partner of the Nucleosome Remodeling and Deacetylase (NuRD) complex.	SCAF1 DIMT1 DDX50 FXR2	2.05e-04	330	31	4	33301849
Pubmed	Microarray expression profiling of tissues from mice with uniparental duplications of chromosomes 7 and 11 to identify imprinted genes.	IGF2-AS ZRSR2	2.10e-04	24	31	2	11668390
Pubmed	PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry.	DDX23 MIDEAS TERF2 RFWD3	2.29e-04	340	31	4	24332808
Pubmed	Human Regulatory Protein Ki-1/57 Is a Target of SUMOylation and Affects PML Nuclear Body Formation.	SCAF1 DIMT1 FXR2	2.32e-04	134	31	3	28695742
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	FBRSL1 TOMM70 ADCY6 RFWD3 ZNF574	2.55e-04	650	31	5	38777146
Pubmed	SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.	DDX23 DDX50 SRRM2 MIDEAS FXR2	2.64e-04	655	31	5	35819319
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	SCAF1 TOMM70 DIMT1 LSM14B DDX50 TERF2 ZNF574	2.86e-04	1497	31	7	31527615
Pubmed	Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage.	DDX23 TERF2 FXR2	3.17e-04	149	31	3	25184681
Pubmed	A protein-RNA interaction atlas of the ribosome biogenesis factor AATF.	DDX50 SRRM2 FXR2	4.05e-04	162	31	3	31363146
Pubmed	Matrix-screening reveals a vast potential for direct protein-protein interactions among RNA binding proteins.	DDX23 DIMT1 DDX50 ZRSR2 FXR2	4.16e-04	723	31	5	34133714
Pubmed	Rewiring of RSK-PDZ Interactome by Linear Motif Phosphorylation.	PDZD7 GRID2IP	4.24e-04	34	31	2	30726710
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	TOMM70 SORBS2 SRRM2 ADCY6	4.53e-04	407	31	4	12693553
Pubmed	ZBTB10 binds the telomeric variant repeat TTGGGG and interacts with TRF2.	TERF2 FXR2	5.30e-04	38	31	2	30629181
Pubmed	Novel gene function revealed by mouse mutagenesis screens for models of age-related disease.	ZFYVE26 PDZD7	7.11e-04	44	31	2	27534441
Pubmed	The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1.	SRRM2 TERF2 FXR2	7.16e-04	197	31	3	20811636
Pubmed	The CRL4DCAF6 E3 ligase ubiquitinates CtBP1/2 to induce apoptotic signalling and promote intervertebral disc degeneration.	SRRM2 ADCY6 RFWD3	7.37e-04	199	31	3	36688959
Pubmed	Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.	DIMT1 DOT1L DDX50 SRRM2 FXR2	8.50e-04	847	31	5	35850772
Pubmed	Poly(ADP-ribosyl)ation of BRD7 by PARP1 confers resistance to DNA-damaging chemotherapeutic agents.	DDX50 SRRM2 TERF2 FXR2	8.79e-04	486	31	4	30940648
Interaction	DDX50 interactions	DDX23 CACTIN DOT1L DDX50 SRRM2 FXR2 ZNF574	1.02e-07	257	31	7	int:DDX50
Interaction	SRSF6 interactions	DDX23 SCAF1 CACTIN DOT1L DDX50 SRRM2 TERF2 ZNF574	6.78e-07	503	31	8	int:SRSF6
Interaction	SRPK2 interactions	DDX23 SCAF1 CACTIN DOT1L DDX50 SRRM2 ZRSR2 FXR2 PNMA8B	8.67e-07	717	31	9	int:SRPK2
Interaction	FBL interactions	CACTIN DIMT1 DOT1L LSM14B DDX50 SRRM2 TERF2 FXR2	4.04e-06	639	31	8	int:FBL
Interaction	SRSF4 interactions	DDX23 SCAF1 DOT1L SRRM2 ZNF574 ZNF646	5.57e-06	300	31	6	int:SRSF4
Interaction	SRSF5 interactions	SCAF1 DOT1L DDX50 SRRM2 ZRSR2 ZNF574 ZNF646	6.14e-06	474	31	7	int:SRSF5
Interaction	ORC1 interactions	DIMT1 DOT1L TERF2 RFWD3	8.91e-06	86	31	4	int:ORC1
Interaction	KAT6A interactions	SCAF1 DIMT1 LSM14B DDX50 TERF2 FXR2 ZNF574	9.90e-06	510	31	7	int:KAT6A
Interaction	SNRNP70 interactions	DDX23 SCAF1 CACTIN DIMT1 LSM14B DDX50 SRRM2 TERF2 FXR2	1.16e-05	984	31	9	int:SNRNP70
Interaction	DDX54 interactions	DDX23 CACTIN DOT1L LSM14B DDX50 FXR2	1.62e-05	362	31	6	int:DDX54
Interaction	MYCN interactions	DDX23 BMP1 SCAF1 DIMT1 DOT1L LSM14B DDX50 SRRM2 MIDEAS FXR2	2.46e-05	1373	31	10	int:MYCN
Interaction	XAGE1A interactions	SRRM2 TERF2 ZNF574	3.38e-05	41	31	3	int:XAGE1A
Interaction	PAXBP1 interactions	DDX23 CACTIN DOT1L TERF2	3.43e-05	121	31	4	int:PAXBP1
Interaction	LIN28A interactions	SCAF1 CACTIN DIMT1 DOT1L DDX50 ZNF574	3.79e-05	421	31	6	int:LIN28A
Interaction	SRSF7 interactions	DDX23 SCAF1 DOT1L DDX50 SRRM2 ZNF574	4.00e-05	425	31	6	int:SRSF7
Interaction	ZC3H18 interactions	DDX23 DIMT1 DOT1L LSM14B DDX50 SRRM2 TERF2 FXR2	4.02e-05	877	31	8	int:ZC3H18
Interaction	SNRNP40 interactions	DDX23 SCAF1 CACTIN DOT1L DDX50 SRRM2 MIDEAS	4.14e-05	637	31	7	int:SNRNP40
Interaction	DHX8 interactions	DDX23 SCAF1 CACTIN DOT1L SRRM2	7.70e-05	292	31	5	int:DHX8
Interaction	KCNRG interactions	KCNA4 FXR2	8.19e-05	9	31	2	int:KCNRG
Interaction	NKAPD1 interactions	DDX23 SCAF1 CACTIN SRRM2	1.04e-04	161	31	4	int:NKAPD1
Interaction	INO80B interactions	SCAF1 CACTIN DOT1L DDX50	1.20e-04	167	31	4	int:INO80B
Interaction	PRPF6 interactions	DDX23 DOT1L SRRM2 ZRSR2 FXR2	1.49e-04	336	31	5	int:PRPF6
Interaction	GATA3 interactions	FBRSL1 TOMM70 DOT1L MIDEAS	1.86e-04	187	31	4	int:GATA3
Interaction	SRSF1 interactions	SCAF1 DOT1L DDX50 SRRM2 ZRSR2 ZNF574	2.01e-04	570	31	6	int:SRSF1
Interaction	CIT interactions	DDX23 SCAF1 CACTIN SORBS2 DIMT1 DDX50 SRRM2 FXR2 ZNF574	2.38e-04	1450	31	9	int:CIT
Interaction	LYAR interactions	DDX23 DOT1L SRRM2 TERF2 RFWD3	2.42e-04	373	31	5	int:LYAR
Interaction	TLE3 interactions	FBRSL1 CACTIN DOT1L SRRM2 MIDEAS	2.51e-04	376	31	5	int:TLE3
Interaction	AATF interactions	DDX23 DOT1L DDX50 SRRM2 FXR2	2.51e-04	376	31	5	int:AATF
Interaction	SRSF11 interactions	DDX23 DOT1L SRRM2 TERF2	2.54e-04	203	31	4	int:SRSF11
Interaction	H2BC13 interactions	SCAF1 TOMM70 DOT1L SRRM2	2.89e-04	210	31	4	int:H2BC13
Interaction	OBSL1 interactions	DDX23 SCAF1 KCNA4 DDX50 SRRM2 MIDEAS FXR2	3.60e-04	902	31	7	int:OBSL1
Interaction	OASL interactions	SCAF1 DDX50 ZNF574 ZNF646	3.63e-04	223	31	4	int:OASL
Interaction	FXR2 interactions	DOT1L LSM14B DDX50 TERF2 FXR2	4.64e-04	430	31	5	int:FXR2
Interaction	U2AF1 interactions	DDX23 DOT1L SRRM2 ZRSR2	4.72e-04	239	31	4	int:U2AF1
Interaction	LUC7L interactions	DOT1L LSM14B DDX50 SRRM2	4.95e-04	242	31	4	int:LUC7L
Interaction	ERH interactions	DDX23 DOT1L TERF2 ZNF574	5.18e-04	245	31	4	int:ERH
Interaction	DHX40 interactions	DDX23 SCAF1 CACTIN TERF2	5.51e-04	249	31	4	int:DHX40
Interaction	RNF113A interactions	DDX23 DDX50 SRRM2 MIDEAS TERF2 FXR2	5.67e-04	692	31	6	int:RNF113A
Interaction	MUS81 interactions	DDX23 DOT1L TERF2	6.20e-04	109	31	3	int:MUS81
Interaction	RRP8 interactions	SCAF1 DOT1L DDX50 FXR2	6.38e-04	259	31	4	int:RRP8
Interaction	SRRM2 interactions	DDX23 DOT1L DDX50 SRRM2 TERF2	6.43e-04	462	31	5	int:SRRM2
Interaction	REXO4 interactions	DDX23 DOT1L ZNF574 ZNF646	6.57e-04	261	31	4	int:REXO4
Interaction	IFI16 interactions	DDX23 DOT1L DDX50 SRRM2 FXR2 ZNF574	6.68e-04	714	31	6	int:IFI16
Interaction	RSBN1L interactions	DDX23 SRRM2 TERF2	7.06e-04	114	31	3	int:RSBN1L
Interaction	RPS16 interactions	DDX23 DIMT1 DOT1L DDX50 FXR2 ZNF574	7.19e-04	724	31	6	int:RPS16
Interaction	TBXT interactions	FBRSL1 DOT1L MIDEAS	7.43e-04	116	31	3	int:TBXT
Interaction	SRPK1 interactions	DDX23 DIMT1 DOT1L SRRM2 ZRSR2	7.43e-04	477	31	5	int:SRPK1
Interaction	BCAS2 interactions	DDX23 CACTIN DOT1L SRRM2	7.46e-04	270	31	4	int:BCAS2
Interaction	DDX23 interactions	DDX23 SCAF1 CACTIN DDX50 SRRM2	7.64e-04	480	31	5	int:DDX23
Interaction	MEN1 interactions	DDX23 DIMT1 DOT1L DDX50 SRRM2 MIDEAS FXR2	7.92e-04	1029	31	7	int:MEN1
Interaction	KIF23 interactions	DDX23 TOMM70 DIMT1 DOT1L DDX50 SRRM2 FXR2	8.01e-04	1031	31	7	int:KIF23
Interaction	RPL10A interactions	DIMT1 DOT1L DDX50 ZRSR2 ZNF574	8.39e-04	490	31	5	int:RPL10A
Interaction	TTC14 interactions	DDX23 SRRM2	8.44e-04	28	31	2	int:TTC14
Interaction	H2AC4 interactions	DDX23 DDX50 MIDEAS TERF2 FXR2	9.69e-04	506	31	5	int:H2AC4
Interaction	PRPF3 interactions	DDX23 CACTIN DOT1L SRRM2	9.85e-04	291	31	4	int:PRPF3
Interaction	SPATS2L interactions	DOT1L ZRSR2 ZNF574	9.88e-04	128	31	3	int:SPATS2L
Interaction	MARF1 interactions	LSM14B TERF2 FXR2	9.88e-04	128	31	3	int:MARF1
Interaction	NR2C2 interactions	DDX23 SCAF1 CACTIN DIMT1 DOT1L DDX50 SRRM2 FXR2	1.00e-03	1403	31	8	int:NR2C2
Interaction	SF3B2 interactions	DOT1L SRRM2 TERF2 ZRSR2 FXR2	1.07e-03	517	31	5	int:SF3B2
Interaction	CCNK interactions	DDX23 DOT1L ZNF574	1.08e-03	132	31	3	int:CCNK
Interaction	SRSF3 interactions	SCAF1 CACTIN DOT1L SRRM2 ZNF574	1.11e-03	522	31	5	int:SRSF3
Interaction	PNN interactions	DDX23 SCAF1 DOT1L SRRM2	1.13e-03	302	31	4	int:PNN
Interaction	CPSF6 interactions	DDX23 DDX50 SRRM2 TERF2 FXR2	1.15e-03	526	31	5	int:CPSF6
Interaction	RBM5 interactions	DDX23 DOT1L ZRSR2	1.15e-03	135	31	3	int:RBM5
Interaction	SAP18 interactions	DDX23 SCAF1 DOT1L SRRM2	1.17e-03	305	31	4	int:SAP18
Interaction	BMP4 interactions	DIMT1 SRRM2 FXR2	1.18e-03	136	31	3	int:BMP4
Interaction	RNGTT interactions	SCAF1 SRRM2 ZNF574	1.20e-03	137	31	3	int:RNGTT
GeneFamily	DEAD-box helicases	DDX23 DDX50	9.75e-04	42	20	2	499
GeneFamily	GATA zinc finger domain containing\|Myb/SANT domain containing	MIDEAS TERF2	1.55e-03	53	20	2	532
GeneFamily	PDZ domain containing	PDZD7 GRID2IP	1.21e-02	152	20	2	1220
Coexpression	GINESTIER_BREAST_CANCER_ZNF217_AMPLIFIED_DN	FBRSL1 SCAF1 CACTIN LTB4R DOT1L LSM14B SRRM2 FXR2 ZNF646	1.92e-10	338	32	9	M17094
Coexpression	HOUNKPE_HOUSEKEEPING_GENES	DDX23 SCAF1 TOMM70 CACTIN DIMT1 LSM14B ZRSR2 FXR2	4.82e-05	1129	32	8	M42508
Coexpression	HOUNKPE_HOUSEKEEPING_GENES	DDX23 SCAF1 TOMM70 CACTIN DIMT1 LSM14B ZRSR2 FXR2	5.77e-05	1158	32	8	MM1338
Coexpression	GSE19401_PAM2CSK4_VS_RETINOIC_ACID_STIM_FOLLICULAR_DC_DN	CACTIN DOT1L SRRM2 ZRSR2	9.25e-05	196	32	4	M7672
Coexpression	GSE7852_TREG_VS_TCONV_FAT_UP	LTB4R KCNA4 DOT1L LAPTM4B	1.00e-04	200	32	4	M5733
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BMP1 SCAF1 GRID2IP TERF2	7.14e-06	174	32	4	f1fe1f4216748a9562dd03bd48c70b23c7ff4d1d
Drug	Trimetazidine dihydrochloride [13171-25-0]; Up 200; 11.8uM; MCF7; HT_HG-U133A	BMP1 C10orf95 CACTIN FXR2 ZNF646	6.69e-06	198	31	5	5479_UP
Drug	Tridihexethyl chloride; Up 200; 11.4uM; MCF7; HT_HG-U133A	BMP1 CACTIN SRRM2 FXR2	1.34e-04	194	31	4	3526_UP
Drug	Phenazopyridine hydrochloride [136-40-3]; Up 200; 16uM; MCF7; HT_HG-U133A	BMP1 ZFYVE26 ZRSR2 ADCY6	1.37e-04	195	31	4	6234_UP
Drug	Protriptyline hydrochloride [1225-55-4]; Down 200; 13.4uM; PC3; HT_HG-U133A	BMP1 CACTIN SRRM2 FXR2	1.37e-04	195	31	4	6338_DN
Drug	Clidinium bromide [3485-62-9]; Down 200; 9.2uM; MCF7; HT_HG-U133A	BMP1 CACTIN ZFYVE26 FXR2	1.37e-04	195	31	4	3476_DN
Drug	Hesperetin [520-33-2]; Down 200; 13.2uM; MCF7; HT_HG-U133A	CACTIN LSM14B FXR2 ZNF574	1.40e-04	196	31	4	1531_DN
Drug	Florfenicol [73231-34-2]; Down 200; 11.2uM; MCF7; HT_HG-U133A	C10orf95 CACTIN DIMT1 LSM14B	1.40e-04	196	31	4	6460_DN
Drug	Oxamniquine [21738-42-1]; Down 200; 14.4uM; HL60; HT_HG-U133A	ZFYVE26 PDZD7 LTB4R DIMT1	1.40e-04	196	31	4	2924_DN
Drug	Desipramine hydrochloride [58-28-6]; Down 200; 13.2uM; MCF7; HT_HG-U133A	LSM14B SRRM2 FXR2 ZNF574	1.42e-04	197	31	4	3212_DN
Drug	Piperidolate hydrochloride [129-77-1]; Up 200; 11.2uM; MCF7; HT_HG-U133A	BMP1 C10orf95 PDZD7 DIMT1	1.42e-04	197	31	4	6772_UP
Drug	Flurandrenolide [1524-88-5]; Down 200; 9.2uM; MCF7; HT_HG-U133A	BMP1 C10orf95 DIMT1 ADCY6	1.42e-04	197	31	4	4702_DN
Drug	Chlorzoxazone [95-25-0]; Down 200; 23.6uM; MCF7; HT_HG-U133A	BMP1 CACTIN DIMT1 FXR2	1.42e-04	197	31	4	2263_DN
Drug	Chlorpromazine hydrochloride [69-09-0]; Down 200; 11.2uM; MCF7; HT_HG-U133A	CACTIN DIMT1 LSM14B SRRM2	1.42e-04	197	31	4	5493_DN
Drug	Amprolium hydrochloride [137-88-2]; Down 200; 12.6uM; MCF7; HT_HG-U133A	BMP1 CACTIN FXR2 ADCY6	1.45e-04	198	31	4	4825_DN
Drug	Eserine sulfate, physostigmine sulfate [64-47-1]; Up 200; 6.2uM; MCF7; HT_HG-U133A	BMP1 C10orf95 LSM14B ZNF646	1.45e-04	198	31	4	2768_UP
Drug	Tetracycline hydrochloride [64-75-5]; Down 200; 8.4uM; PC3; HT_HG-U133A	BMP1 TOMM70 FXR2 ZNF574	1.45e-04	198	31	4	2080_DN
Drug	Paromomycin sulfate [1263-89-4]; Down 200; 5.6uM; PC3; HT_HG-U133A	LTB4R DIMT1 LSM14B FXR2	1.45e-04	198	31	4	4595_DN
Drug	Tranexamic acid [1197-18-8]; Down 200; 25.4uM; PC3; HT_HG-U133A	CACTIN SRRM2 ADCY6 ZNF574	1.45e-04	198	31	4	2085_DN
Drug	(S)-propranolol hydrochloride [4199-10-4]; Down 200; 13.6uM; MCF7; HT_HG-U133A	C10orf95 LTB4R DIMT1 LSM14B	1.45e-04	198	31	4	5444_DN
Drug	L(-)-vesamicol hydrochloride [112709-59-8]; Up 200; 13.6uM; MCF7; HT_HG-U133A	BMP1 C10orf95 CACTIN ZNF646	1.48e-04	199	31	4	5475_UP
Drug	Moxisylyte hydrochoride [964-52-3]; Down 200; 12.6uM; MCF7; HT_HG-U133A	BMP1 CACTIN FXR2 ADCY6	1.51e-04	200	31	4	1682_DN
Drug	Dubinidine [22964-77-8]; Down 200; 14.6uM; PC3; HT_HG-U133A	BMP1 CACTIN LSM14B ADCY6	1.51e-04	200	31	4	5774_DN
Drug	Felbinac [5728-52-9]; Up 200; 18.8uM; MCF7; HT_HG-U133A	C10orf95 CACTIN LTB4R ZNF646	1.51e-04	200	31	4	3398_UP
Disease	Myoinositol measurement	FBRSL1 LAPTM4B	7.00e-05	12	31	2	EFO_0021652
Disease	cardiovascular disease	FBRSL1 DDX23 SCAF1 TERF2	1.28e-03	457	31	4	EFO_0000319
Disease	non-high density lipoprotein cholesterol measurement	FBRSL1 KCNA4 MIDEAS ZNF574	6.33e-03	713	31	4	EFO_0005689
Disease	Myopia	FBRSL1 KCNA4 RFWD3	7.56e-03	385	31	3	HP_0000545

Protein segments in the cluster

Peptide	Gene	Start	Entry
RSRSRLRRRSRSRGG	PRPF4B	476	Q13523
SRAQRDRGRRREAAR	FBRSL1	11	Q9HCM7
ERNGQKRSRRRGTRA	ADCY6	21	O43306
QDSRRRGRRKRASAG	DOT1L	1081	Q8TEK3
RWRGRSRSRRAATSR	BMP1	111	P13497
TRRRVSASRRARAGG	RFWD3	151	Q6PCD5
RPQRRNRSRRRRNRG	FXR2	581	P51116
NRSRRRRNRGNRTDG	FXR2	586	P51116
NRRPQRRRSGNRRTR	LSM14B	216	Q9BX40
RRRSGNRRTRNRSRG	LSM14B	221	Q9BX40
IRGRAQSRSRSRSRS	PDZD7	766	Q9H5P4
RSRQQRRGGLQARRS	LAPTM4B	61	Q86VI4
RRSCGNTRRCRSRRS	GOLGA6L2	706	Q8N9W4
DRRRGGSRSRSRSRS	DDX23	51	Q9BUQ8
RRLQARRFRRSRRTG	LTB4R	206	Q15722
RSGAQRRRGSARRGA	IGF2-AS	56	Q6U949
ARRAQGAQRLRRSRS	GRID2IP	221	A4D2P6
RQGSRSGSRQDGRRR	DDX50	706	Q9BQ39
DGRRRSGNRNRSRSG	DDX50	716	Q9BQ39
LRGGVIQSTRRRRRA	MIDEAS	446	Q6PJG2
RSRSRSAGRRGRRRQ	CACTIN	6	Q8WUQ7
GRRRQSQSGSRSRSR	CACTIN	16	Q8WUQ7
RTRARGRARRRESYQ	PIWIL3	6	Q7Z3Z3
SGAIGRRRGRQEQRR	DIMT1	6	Q9UNQ2
GWSRSRNTQRRGRSR	SRRM2	541	Q9UQ35
RNTQRRGRSRSARRG	SRRM2	546	Q9UQ35
RGRSRSARRGRSHSR	SRRM2	551	Q9UQ35
NPRRGRRGRRNRTRR	PNMA8B	156	Q9ULN7
RRGRRNRTRRNRLTQ	PNMA8B	161	Q9ULN7
RSNGRSRIRHRSARN	SORBS2	431	O94875
AGRRPNRASGRRRRS	C10orf95	51	Q9H7T3
RSRSTDRRRGGSRRS	SCAF1	586	Q9H7N4
RDRRGRRARRNNSGE	ZNF574	286	Q6ZN55
NRRRRAGRSRRTAVR	ZNF646	1351	O15015
RQQRRREARGRGDAS	TOMM70	61	O94826
NYKSSQARRGRRGRR	TMEM271	241	A0A286YF58
ASRARRGRRGRRGRR	TMEM271	276	A0A286YF58
LRRGRRTRRSQADGR	ZFYVE26	766	Q68DK2
NRDRSRDRSRGRGSR	ZRSR2	426	Q15696
RDRSRGRGSRSRSRS	ZRSR2	431	Q15696
GRGSRSRSRSRSRRS	ZRSR2	436	Q15696
QSSSRSRSRGRRRSG	ZRSR2	456	Q15696
SRSRGRRRSGNRDRT	ZRSR2	461	Q15696
AAGRRASRSSGRARR	TERF2	56	Q15554
PQSSRGSRRRRRQRS	KCNA4	76	P22459