Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	testosterone 6-beta-hydroxylase activity	CYP3A7 CYP3A4	1.10e-04	5	67	2	GO:0050649
GeneOntologyMolecularFunction	RNA polymerase III type 3 promoter sequence-specific DNA binding	MTOR SNAPC4	1.65e-04	6	67	2	GO:0001006
GeneOntologyMolecularFunction	RNA polymerase III cis-regulatory region sequence-specific DNA binding	MTOR SNAPC4	2.30e-04	7	67	2	GO:0000992
GeneOntologyMolecularFunction	RNA polymerase III transcription regulatory region sequence-specific DNA binding	MTOR SNAPC4	3.07e-04	8	67	2	GO:0001016
GeneOntologyMolecularFunction	histone H3K4 monomethyltransferase activity	KMT2D SETD1B	3.07e-04	8	67	2	GO:0140945
GeneOntologyMolecularFunction	estrogen 2-hydroxylase activity	CYP3A7 CYP3A4	3.07e-04	8	67	2	GO:0101021
GeneOntologyMolecularFunction	histone H3K4 trimethyltransferase activity	KMT2D SETD1B	4.91e-04	10	67	2	GO:0140999
GeneOntologyMolecularFunction	estrogen 16-alpha-hydroxylase activity	CYP3A7 CYP3A4	5.98e-04	11	67	2	GO:0101020
GeneOntologyMolecularFunction	retinoic acid 4-hydroxylase activity	CYP3A7 CYP3A4	9.83e-04	14	67	2	GO:0008401
GeneOntologyBiologicalProcess	iodide transmembrane transport	SLC5A5 MTOR	2.93e-05	3	65	2	GO:1904200
GeneOntologyBiologicalProcess	transcription by RNA polymerase III	MTOR NAB2 BAZ1B SNAPC4	4.65e-05	63	65	4	GO:0006383
GeneOntologyBiologicalProcess	transcription initiation-coupled chromatin remodeling	PHF2 NIBAN2 SGF29 MEN1	5.26e-05	65	65	4	GO:0045815
GeneOntologyBiologicalProcess	demethylation	PHF2 CYP3A7 CYP3A4	5.77e-05	24	65	3	GO:0070988
GeneOntologyBiologicalProcess	positive regulation of gene expression, epigenetic	PHF2 NIBAN2 SGF29 MEN1	6.29e-05	68	65	4	GO:0141137
GeneOntologyBiologicalProcess	chromatin remodeling	PHF2 KMT2D SETD1B NFE2 BAZ1B CHD3 NIBAN2 CABIN1 SGF29 MEN1	1.01e-04	741	65	10	GO:0006338
GeneOntologyBiologicalProcess	regulation of transcription by RNA polymerase III	MTOR NAB2 BAZ1B	1.39e-04	32	65	3	GO:0006359
GeneOntologyBiologicalProcess	regulation of dendritic spine development	SHANK1 CUX2 MTOR ASAP1	1.95e-04	91	65	4	GO:0060998
GeneOntologyBiologicalProcess	regulation of nervous system process	SHANK1 CUX2 NETO1 ZFHX2 TNFRSF1B	2.27e-04	175	65	5	GO:0031644
Domain	Cyt_P450_E_grp-II	CYP3A7 CYP3A4	1.22e-04	5	66	2	IPR002402
Domain	PHD	PHF2 KMT2D BAZ1B CHD3	1.43e-04	75	66	4	PF00628
Domain	Znf_PHD-finger	PHF2 KMT2D BAZ1B CHD3	1.75e-04	79	66	4	IPR019787
Domain	Cyt_P450_E_CYP3A	CYP3A7 CYP3A4	1.83e-04	6	66	2	IPR008072
Domain	PHD	PHF2 KMT2D BAZ1B CHD3	2.77e-04	89	66	4	SM00249
Domain	Znf_PHD	PHF2 KMT2D BAZ1B CHD3	3.02e-04	91	66	4	IPR001965
Domain	ZF_PHD_2	PHF2 KMT2D BAZ1B CHD3	3.56e-04	95	66	4	PS50016
Domain	ZF_PHD_1	PHF2 KMT2D BAZ1B CHD3	3.70e-04	96	66	4	PS01359
Domain	-	TCF7 KMT2D CHD3	9.70e-04	55	66	3	1.10.30.10
Domain	Post-SET_dom	KMT2D SETD1B	1.43e-03	16	66	2	IPR003616
Domain	PostSET	KMT2D SETD1B	1.43e-03	16	66	2	SM00508
Domain	POST_SET	KMT2D SETD1B	1.43e-03	16	66	2	PS50868
Domain	HMG_box_dom	TCF7 KMT2D CHD3	1.57e-03	65	66	3	IPR009071
Domain	Zinc_finger_PHD-type_CS	PHF2 BAZ1B CHD3	1.57e-03	65	66	3	IPR019786
Domain	Znf_FYVE_PHD	PHF2 KMT2D BAZ1B CHD3	1.82e-03	147	66	4	IPR011011
Domain	-	CUX2 POU5F2	4.08e-03	27	66	2	1.10.260.40
Domain	Lambda_DNA-bd_dom	CUX2 POU5F2	4.70e-03	29	66	2	IPR010982
Pathway	REACTOME_FORMATION_OF_WDR5_CONTAINING_HISTONE_MODIFYING_COMPLEXES	KMT2D SETD1B SGF29 MEN1	7.37e-06	38	47	4	MM17073
Pathway	REACTOME_FORMATION_OF_WDR5_CONTAINING_HISTONE_MODIFYING_COMPLEXES	KMT2D SETD1B SGF29 MEN1	1.11e-05	42	47	4	M48018
Pathway	REACTOME_FORMATION_OF_THE_BETA_CATENIN_TCF_TRANSACTIVATING_COMPLEX	TCF7 KMT2D MEN1	8.56e-05	26	47	3	MM14793
Pathway	REACTOME_EPIGENETIC_REGULATION_OF_GENE_EXPRESSION	KMT2D SETD1B BAZ1B SGF29 MEN1	8.60e-05	136	47	5	MM14848
Pathway	REACTOME_GENE_EXPRESSION_TRANSCRIPTION	TCF7 KMT2D SETD1B NRBF2 MTOR BAZ1B CHD3 SNAPC4 SGF29 AFF4 CDK4 MEN1	9.60e-05	1022	47	12	MM15436
Pathway	REACTOME_EPIGENETIC_REGULATION_OF_GENE_EXPRESSION	KMT2D SETD1B BAZ1B CHD3 SGF29 MEN1	1.86e-04	254	47	6	M27131
Pathway	REACTOME_CHROMATIN_MODIFYING_ENZYMES	PHF2 KMT2D SETD1B CHD3 SGF29 CDK4	2.70e-04	272	47	6	M29619
Pathway	REACTOME_CHROMATIN_MODIFYING_ENZYMES	PHF2 KMT2D SETD1B CHD3 CDK4	2.80e-04	175	47	5	MM14941
Pathway	REACTOME_DEACTIVATION_OF_THE_BETA_CATENIN_TRANSACTIVATING_COMPLEX	TCF7 KMT2D MEN1	3.64e-04	42	47	3	M27272
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	PALD1 KMT2D SETD1B WIZ MTOR WDR70 ANKRD11 TBC1D25 MICAL3 EDC4 SNAPC4 CABIN1 PRAG1 ZDHHC8 AGRN AHDC1 AHNAK2	2.29e-11	1105	67	17	35748872
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	PALD1 CRACD WIZ NRBF2 ZNF280C WDR70 BAZ1B CHD3 NIBAN2 EDC4 RRBP1 PRRC2A AFF4 AHNAK2	2.41e-09	934	67	14	33916271
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	PHF2 WIZ ZNF280C WDR70 BAZ1B CHD3 SNAPC4 CABIN1 AFF4 MEN1	2.51e-07	608	67	10	36089195
Pubmed	The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1.	PHF2 KMT2D SETD1B ANKRD11 BAZ1B CHD3	6.11e-07	157	67	6	30186101
Pubmed	Activator-mediated recruitment of the MLL2 methyltransferase complex to the beta-globin locus.	KMT2D NFE2 MEN1	1.48e-06	12	67	3	17707229
Pubmed	Quantitative dissection and stoichiometry determination of the human SET1/MLL histone methyltransferase complexes.	KMT2D SETD1B RRBP1 SGF29 MEN1	3.51e-06	119	67	5	23508102
Pubmed	The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.	FLNB ANKRD11 BAZ1B CHD3 PRRC2A AHDC1 AHNAK2	3.61e-06	332	67	7	37433992
Pubmed	Digging Deeper into CYP3A Testosterone Metabolism: Kinetic, Regioselectivity, and Stereoselectivity Differences between CYP3A4/5 and CYP3A7.	CYP3A7 CYP3A4	3.66e-06	2	67	2	28986474
Pubmed	Differential regulation of CYP3A4 and CYP3A7 by dimethylsulfoxide in primary human hepatocytes.	CYP3A7 CYP3A4	3.66e-06	2	67	2	15379787
Pubmed	Dynamics of Cytosine Methylation in the Proximal Promoters of CYP3A4 and CYP3A7 in Pediatric and Prenatal Livers.	CYP3A7 CYP3A4	3.66e-06	2	67	2	26772622
Pubmed	Role of Chromatin Structural Changes in Regulating Human CYP3A Ontogeny.	CYP3A7 CYP3A4	3.66e-06	2	67	2	26921389
Pubmed	Molecular mechanisms of polymorphic CYP3A7 expression in adult human liver and intestine.	CYP3A7 CYP3A4	3.66e-06	2	67	2	11940601
Pubmed	Knockout of ASAP1 induces autophagy in papillary thyroid carcinoma by inhibiting the mTOR signaling pathway.	MTOR ASAP1	3.66e-06	2	67	2	32307199
Pubmed	Circumvent hesitancy between CDK4/6 and mTOR inhibitors in second-line treatment of HR+, erb2- metastatic breast cancer.	MTOR CDK4	3.66e-06	2	67	2	28685610
Pubmed	Expression of CYP3A4 and CYP3A7 in Human Foetal Tissues and its Correlation with Nuclear Receptors.	CYP3A7 CYP3A4	3.66e-06	2	67	2	25689036
Pubmed	Immunohistochemical markers of CYP3A4 and CYP3A7: a new tool towards personalized pharmacotherapy of hepatocellular carcinoma.	CYP3A7 CYP3A4	3.66e-06	2	67	2	27349315
Pubmed	Developmental regulation of CYP3A4 and CYP3A7 in Chinese Han population.	CYP3A7 CYP3A4	3.66e-06	2	67	2	27727071
Pubmed	Expression and cyclic variability of CYP3A4 and CYP3A7 isoforms in human endometrium and cervix during the menstrual cycle.	CYP3A7 CYP3A4	3.66e-06	2	67	2	12485945
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	KMT2D WIZ BAZ1B CHD3 EDC4 AFF4 MEN1	4.30e-06	341	67	7	32971831
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	PHF2 FLNB NETO1 WDR70 ANKRD11 ZFHX2 CILK1 MICAL3 CHD3 RRBP1 AHDC1 NBR1 AFF4	4.52e-06	1489	67	13	28611215
Pubmed	A High-Density Map for Navigating the Human Polycomb Complexome.	KMT2D SETD1B WIZ ZNF280C CHD3 SGF29 AHDC1 MEN1	4.97e-06	495	67	8	27705803
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	NAPSA PHF2 KMT2D WIZ ANKRD11 BAZ1B CHD3 RRBP1 CABIN1 SGF29 AHDC1 MEN1	6.04e-06	1294	67	12	30804502
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	PHF2 PRAM1 KMT2D WIZ NAB2 RPUSD2 CHD3 EDC4 SGF29 PRRC2A AHDC1	7.85e-06	1103	67	11	34189442
Pubmed	Structural basis for activity regulation of MLL family methyltransferases.	KMT2D SETD1B MEN1	1.03e-05	22	67	3	26886794
Pubmed	The P450 oxidoreductase genotype is associated with CYP3A activity in vivo as measured by the midazolam phenotyping test.	CYP3A7 CYP3A4	1.10e-05	3	67	2	19801957
Pubmed	Metabolic pathways of inhaled glucocorticoids by the CYP3A enzymes.	CYP3A7 CYP3A4	1.10e-05	3	67	2	23143891
Pubmed	Development of template systems for ligand interactions of CYP3A5 and CYP3A7 and their distinctions from CYP3A4 template.	CYP3A7 CYP3A4	1.10e-05	3	67	2	33866277
Pubmed	Intestinal cell kinase (ICK) promotes activation of mTOR complex 1 (mTORC1) through phosphorylation of Raptor Thr-908.	MTOR CILK1	1.10e-05	3	67	2	22356909
Pubmed	Cytochrome P450 3A gene variation, steroid hormone serum levels and prostate cancer--The Rotterdam Study.	CYP3A7 CYP3A4	1.10e-05	3	67	2	20621111
Pubmed	Combined CDK4/6 and Pan-mTOR Inhibition Is Synergistic Against Intrahepatic Cholangiocarcinoma.	MTOR CDK4	1.10e-05	3	67	2	30084835
Pubmed	Contribution of three CYP3A isoforms to metabolism of R- and S-warfarin.	CYP3A7 CYP3A4	1.10e-05	3	67	2	20615193
Pubmed	Effects of hypoxia-inducible factor-1α chemical stabilizer, CoCl(2) and hypoxia on gene expression of CYP3As in human fetal liver cells.	CYP3A7 CYP3A4	1.10e-05	3	67	2	22277676
Pubmed	Combination of CDK4/6 and mTOR Inhibitors Suppressed Doxorubicin-resistant Osteosarcoma in a Patient-derived Orthotopic Xenograft Mouse Model: A Translatable Strategy for Recalcitrant Disease.	MTOR CDK4	1.10e-05	3	67	2	34230123
Pubmed	Comparison of steroid hormone hydroxylation mediated by cytochrome P450 3A subfamilies.	CYP3A7 CYP3A4	1.10e-05	3	67	2	32001245
Pubmed	MEN1 tumorigenesis in the pituitary and pancreatic islet requires Cdk4 but not Cdk2.	CDK4 MEN1	1.10e-05	3	67	2	24531709
Pubmed	AFF4 regulates osteogenic potential of human periodontal ligament stem cells via mTOR-ULK1-autophagy axis.	MTOR AFF4	1.10e-05	3	67	2	37731335
Pubmed	CYP3A Polymorphism and Chronic Mercury Intoxication.	CYP3A7 CYP3A4	1.10e-05	3	67	2	32146629
Pubmed	Cell cycle plasticity driven by MTOR signaling: integral resistance to CDK4/6 inhibition in patient-derived models of pancreatic cancer.	MTOR CDK4	1.10e-05	3	67	2	30696953
Pubmed	The mutational landscape of cutaneous T cell lymphoma and Sézary syndrome.	KMT2D CHD3	1.10e-05	3	67	2	26551667
Pubmed	PML-RARα enhances constitutive autophagic activity through inhibiting the Akt/mTOR pathway.	PRAM1 MTOR	1.10e-05	3	67	2	21673516
Pubmed	Distinct pathways affected by menin versus MLL1/MLL2 in MLL-rearranged acute myeloid leukemia.	KMT2D MEN1	1.10e-05	3	67	2	30315824
Pubmed	Differences in CYP3A41G genotype distribution and haplotypes of CYP3A4, CYP3A5 and CYP3A7 in 3 Chinese populations.	CYP3A7 CYP3A4	1.10e-05	3	67	2	17582393
Pubmed	Cytochrome P450 3As gene expression and testosterone 6 beta-hydroxylase activity in human fetal membranes and placenta at full term.	CYP3A7 CYP3A4	1.10e-05	3	67	2	20118548
Pubmed	CYP3A7, CYP3A4, and CYP3A5 genetic polymorphisms in recipients rather than donors influence tacrolimus concentrations in the early stages after liver transplantation.	CYP3A7 CYP3A4	1.10e-05	3	67	2	34688813
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	KMT2D WIZ CHD3 SGF29 AHDC1 AFF4	1.33e-05	268	67	6	33640491
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	PHF2 PRAM1 WIZ ZNF280C ANKRD11 BAZ1B CHD3 RRBP1 PRRC2A AFF4	1.39e-05	954	67	10	36373674
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	SHANK1 WIZ SYT3 NETO1 MTOR EDC4 CABIN1 AGRN PRRC2A AFF4	1.50e-05	963	67	10	28671696
Pubmed	Human transcription factor protein interaction networks.	PHF2 TCF7 KMT2D WIZ BAZ1B CHD3 GIGYF1 USP54 EDC4 CABIN1 SGF29 PRRC2A	1.63e-05	1429	67	12	35140242
Pubmed	Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.	WIZ ZNF280C WDR70 BAZ1B CHD3 AFF4	1.81e-05	283	67	6	30585729
Pubmed	Identification of the SOX2 Interactome by BioID Reveals EP300 as a Mediator of SOX2-dependent Squamous Differentiation and Lung Squamous Cell Carcinoma Growth.	KMT2D WIZ CHD3 CDK4	2.06e-05	83	67	4	28794006
Pubmed	Histopathology of melanosis coli and determination of its associated genes by comparative analysis of expression microarrays.	CYP3A7 CYP3A4	2.19e-05	4	67	2	26238215
Pubmed	Allele and genotype frequencies of CYP3A4, CYP3A5, CYP3A7, and GSTP1 gene polymorphisms among mainland Tibetan, Mongolian, Uyghur, and Han Chinese populations.	CYP3A7 CYP3A4	2.19e-05	4	67	2	34689350
Pubmed	CYP3A7, CYP3A5, CYP3A4, and ABCB1 genetic polymorphisms, cyclosporine concentration, and dose requirement in transplant recipients.	CYP3A7 CYP3A4	2.19e-05	4	67	2	18978522
Pubmed	NAB2 represses transcription by interacting with the CHD4 subunit of the nucleosome remodeling and deacetylase (NuRD) complex.	NAB2 CHD3	2.19e-05	4	67	2	16574654
Pubmed	A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.	TDRD7 GIGYF1 USP54 AGRN PRRC2A AHDC1 NBR1 ARID5A	2.19e-05	608	67	8	16713569
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	PHF2 CRACD WIZ ANKRD11 BAZ1B EDC4 SGF29 AGRN PRRC2A AHDC1 AFF4 MEN1	2.58e-05	1497	67	12	31527615
Pubmed	Interactome mapping of the phosphatidylinositol 3-kinase-mammalian target of rapamycin pathway identifies deformed epidermal autoregulatory factor-1 as a new glycogen synthase kinase-3 interactor.	NRBF2 MTOR NAB2 NBR1	3.09e-05	92	67	4	20368287
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	PHF2 KMT2D WIZ ZNF280C DUSP8 MICAL3 NIBAN2 PRRC2A NBR1 ASAP1	3.11e-05	1049	67	10	27880917
Pubmed	Cytochrome P450 isoforms are differently up-regulated in aflatoxin B₁-exposed human lymphocytes and monocytes.	CYP3A7 CYP3A4	3.64e-05	5	67	2	24168324
Pubmed	Human cytochrome P450 3A7 has a distinct high catalytic activity for the 16alpha-hydroxylation of estrone but not 17beta-estradiol.	CYP3A7 CYP3A4	3.64e-05	5	67	2	14559847
Pubmed	Genomic organization of the human CYP3A locus: identification of a new, inducible CYP3A gene.	CYP3A7 CYP3A4	3.64e-05	5	67	2	11266076
Pubmed	MLL2, Not MLL1, Plays a Major Role in Sustaining MLL-Rearranged Acute Myeloid Leukemia.	KMT2D MEN1	3.64e-05	5	67	2	28609655
Pubmed	p38 MAPK signaling regulates recruitment of Ash2L-containing methyltransferase complexes to specific genes during differentiation.	KMT2D MEN1	3.64e-05	5	67	2	18026121
Pubmed	Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites.	CYP3A7 CYP3A4	3.64e-05	5	67	2	11093772
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	CRACD KMT2D WIZ WDR70 RRBP1 CABIN1 SGF29 NBR1 MEN1	3.82e-05	857	67	9	25609649
Pubmed	A genome- and phenome-wide association study to identify genetic variants influencing platelet count and volume and their pleiotropic effects.	SETD1B NRBF2 NFE2	3.92e-05	34	67	3	24026423
Pubmed	RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.	CHD3 USP54 EDC4 RRBP1 PRRC2A	4.53e-05	202	67	5	24639526
Pubmed	Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	PALD1 CRACD ZDHHC8 ASAP1	4.82e-05	103	67	4	10574462
Pubmed	Vector-capping: a simple method for preparing a high-quality full-length cDNA library.	FLNB AGRN	5.46e-05	6	67	2	16106752
Pubmed	MLL associates specifically with a subset of transcriptionally active target genes.	KMT2D MEN1	5.46e-05	6	67	2	16199523
Pubmed	N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.	FLNB ZNF280C MICAL3 RRBP1 PRRC2A AHNAK2	6.92e-05	360	67	6	33111431
Pubmed	The deubiquitinase USP11 is a versatile and conserved regulator of autophagy.	NRBF2 MTOR	7.63e-05	7	67	2	34600886
Pubmed	The human cytochrome P450 3A locus. Gene evolution by capture of downstream exons.	CYP3A7 CYP3A4	7.63e-05	7	67	2	11137287
Pubmed	Association between ABCC2 polymorphism and lopinavir accumulation in peripheral blood mononuclear cells of HIV-infected patients.	CYP3A7 CYP3A4	7.63e-05	7	67	2	19842932
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	SHANK1 CRACD FLNB SYT3 MICAL3 CHD3 USP54 EDC4 RRBP1 PRRC2A ASAP1	8.50e-05	1431	67	11	37142655
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	PALD1 CRACD FLNB CLGN MTOR MICAL3 EDC4 CABIN1 PRRC2A CDK4 AHNAK2	8.99e-05	1440	67	11	30833792
Pubmed	An improved smaller biotin ligase for BioID proximity labeling.	TDRD7 NETO1 CCDC168 AHNAK2	9.61e-05	123	67	4	26912792
Pubmed	mTORC1 Inactivation Promotes Colitis-Induced Colorectal Cancer but Protects from APC Loss-Dependent Tumorigenesis.	MTOR CDK4	1.02e-04	8	67	2	29275959
Pubmed	MEKK4 signaling regulates filamin expression and neuronal migration.	FLNB MAP3K4	1.02e-04	8	67	2	17145501
Pubmed	A phenotype-genotype approach to predicting CYP450 and P-glycoprotein drug interactions with the mixed inhibitor/inducer tipranavir/ritonavir.	CYP3A7 CYP3A4	1.02e-04	8	67	2	20147896
Pubmed	Skirting the pitfalls: a clear-cut nomenclature for H3K4 methyltransferases.	KMT2D SETD1B	1.02e-04	8	67	2	23130995
Pubmed	The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases.	KMT2D SETD1B	1.02e-04	8	67	2	22266653
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	KMT2D BAZ1B MICAL3 CHD3 NIBAN2 SNAPC4 RRBP1 PRRC2A	1.19e-04	774	67	8	15302935
Pubmed	Epigenetic-focused CRISPR/Cas9 screen identifies (absent, small, or homeotic)2-like protein (ASH2L) as a regulator of glioblastoma cell survival.	KMT2D SETD1B MEN1	1.26e-04	50	67	3	37974198
Pubmed	Menin is required in cranial neural crest for palatogenesis and perinatal viability.	CDK4 MEN1	1.30e-04	9	67	2	17927973
Pubmed	Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases.	KMT2D SETD1B	1.30e-04	9	67	2	22665483
Pubmed	The SUMO-specific isopeptidase SENP3 regulates MLL1/MLL2 methyltransferase complexes and controls osteogenic differentiation.	KMT2D MEN1	1.30e-04	9	67	2	24930734
Pubmed	ISG15 modification of filamin B negatively regulates the type I interferon-induced JNK signalling pathway.	FLNB MAP3K4	1.30e-04	9	67	2	19270716
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	PALD1 CRACD SETD1B MICAL3 ASAP1 MAP3K4	1.35e-04	407	67	6	12693553
Pubmed	The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch.	FLNB CHD3 RRBP1 NBR1 AHNAK2	1.38e-04	256	67	5	33397691
Pubmed	RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.	GIGYF1 USP54 ZDHHC8 NBR1 AHNAK2	1.57e-04	263	67	5	34702444
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	PHF2 CUX2 TCF7 WIZ ZNF280C BAZ1B CHD3 SNAPC4	1.60e-04	808	67	8	20412781
Pubmed	Characterization of the oxidative metabolites of 17beta-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoforms.	CYP3A7 CYP3A4	1.63e-04	10	67	2	12865317
Pubmed	In vivo role of different domains and of phosphorylation in the transcription factor Nkx2-1.	SLC5A5 NAPSA	1.63e-04	10	67	2	21345181
Pubmed	Mutant HTT (huntingtin) impairs mitophagy in a cellular model of Huntington disease.	MTOR NBR1	1.99e-04	11	67	2	32093570
Pubmed	Human CpG binding protein interacts with MLL1, MLL2 and hSet1 and regulates Hox gene expression.	KMT2D MEN1	1.99e-04	11	67	2	18082152
Pubmed	Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.	FLNB WIZ BAZ1B CHD3 NIBAN2 PRRC2A AHDC1 MEN1	2.20e-04	847	67	8	35850772
Pubmed	Mapping a dynamic innate immunity protein interaction network regulating type I interferon production.	PALD1 CLGN EDC4 PRRC2A CDK4	2.20e-04	283	67	5	21903422
Pubmed	De novo genic mutations among a Chinese autism spectrum disorder cohort.	SHANK1 PHF2	2.38e-04	12	67	2	27824329
Pubmed	Targeted Disruption of the Interaction between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase Complexes.	KMT2D SETD1B	2.38e-04	12	67	2	27563068
Interaction	TOP3B interactions	PALD1 KMT2D SETD1B WIZ MTOR WDR70 ANKRD11 TBC1D25 MICAL3 EDC4 SNAPC4 CABIN1 PRAG1 ZDHHC8 AGRN PRRC2A AHDC1 AHNAK2	9.20e-07	1470	67	18	int:TOP3B
Interaction	H3-3A interactions	PHF2 KMT2D SETD1B WIZ ZNF280C WDR70 BAZ1B CHD3 NIBAN2 SNAPC4 CABIN1 AFF4 MEN1	9.25e-07	749	67	13	int:H3-3A
Interaction	ATN1 interactions	SETD1B GIGYF1 USP54 SGF29 AGRN PRRC2A MEN1	2.88e-06	187	67	7	int:ATN1
Interaction	NAA40 interactions	PALD1 CRACD WIZ NRBF2 ZNF280C WDR70 BAZ1B CHD3 NIBAN2 EDC4 RRBP1 PRRC2A AFF4 AHNAK2	3.23e-06	978	67	14	int:NAA40
Interaction	NUP43 interactions	TDRD7 PHF2 KMT2D SETD1B NETO1 ZNF280C ANKRD11 CHD3 CCDC168 AHDC1 AHNAK2	6.20e-06	625	67	11	int:NUP43
Cytoband	Ensembl 112 genes in cytogenetic band chr7q22	CYP3A7 CYP3A4 GIGYF1 NYAP1	3.05e-04	219	67	4	chr7q22
GeneFamily	PHD finger proteins	PHF2 KMT2D BAZ1B CHD3	6.11e-05	90	43	4	88
GeneFamily	Cytochrome P450 family 3	CYP3A7 CYP3A4	1.53e-04	8	43	2	1002
GeneFamily	Zinc fingers C2H2-type\|Lysine methyltransferases\|PR/SET domain family	KMT2D SETD1B	2.95e-03	34	43	2	487
GeneFamily	Tudor domain containing	TDRD7 SGF29	3.49e-03	37	43	2	780
Coexpression	GINESTIER_BREAST_CANCER_ZNF217_AMPLIFIED_DN	KMT2D MTOR BAZ1B GIGYF1 SNAPC4 AGRN PRRC2A CAPN15	2.37e-06	338	67	8	M17094
Coexpression	GSE5099_UNSTIM_VS_MCSF_TREATED_MONOCYTE_DAY7_DN	KMT2D CHD3 EDC4 GPR108 CAPN15 MEN1	1.24e-05	200	67	6	M6585
ToppCell	3'_v3-blood-Lymphocytic_NK-NK_CD56bright_CD16-\|blood / Manually curated celltypes from each tissue	FLNB TCF7 ANKRD11 MICAL3 RRBP1 AHDC1	4.92e-07	195	67	6	1470f562ebcfe7da367964ecfd6c7f43bcdb4a73
ToppCell	BAL-Severe-Myeloid-cDC-cDC-cDC_4\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	NAPSA PALD1 PRAM1 NFE2 CLEC12A	5.48e-06	168	67	5	d60f7cd8269f373827f49c7785002cb38e4570a9
ToppCell	BAL-Severe-Myeloid-cDC-cDC-cDC_4\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	NAPSA PALD1 PRAM1 NFE2 CLEC12A	5.64e-06	169	67	5	ccd98f9005aa0a88bd49f153be4e7200cc3dd0ac
ToppCell	droplet-Pancreas-PANCREAS-30m-Hematologic-leukocyte\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NAPSA TCF7 NFE2 TNFRSF1B CLEC12A	6.14e-06	172	67	5	480f409405d1d35804629e81fc6ec5873a085983
ToppCell	droplet-Pancreas-PANCREAS-30m-Hematologic\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NAPSA TCF7 NFE2 TNFRSF1B CLEC12A	6.14e-06	172	67	5	17938d191e28f88cccf180dc1aaf453a255fc031
ToppCell	ILEUM-inflamed-(3)_pDC\|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	PALD1 FLNB CUX2 ANKRD11 RRBP1	6.87e-06	176	67	5	b9f847dd55703e413f3cd815eef5724fffaf13b3
ToppCell	ILEUM-inflamed-(3)_MNP-(3)_pDC\|(3)_MNP / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	PALD1 FLNB CUX2 ANKRD11 RRBP1	8.75e-06	185	67	5	308a98f111895071d8772bc010554471cc12fab2
ToppCell	Multiple_Sclerosis-Myeloid-pDC\|Multiple_Sclerosis / Disease, Lineage and Cell Type	NAPSA PALD1 CUX2 PANX2 RRBP1	8.98e-06	186	67	5	330a4f669adea91ff9f2dff2de2210f5e3401e19
ToppCell	healthy_donor-Lymphocytic-Dendritic\|healthy_donor / Disease condition, Lineage, Cell class and subclass	PALD1 FLNB CUX2 RRBP1 AHNAK2	8.98e-06	186	67	5	916f2aeea4989ba7a29e071e348a51010f010223
ToppCell	healthy_donor-Lymphocytic-Dendritic-pDC\|healthy_donor / Disease condition, Lineage, Cell class and subclass	PALD1 FLNB CUX2 RRBP1 AHNAK2	8.98e-06	186	67	5	45f66619e45d590c7365a51782d4ac46b7d31fde
ToppCell	5'-Adult-SmallIntestine-Hematopoietic-Myeloid-Monocytes\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PRAM1 CUX2 PANX2 TNFRSF1B CLEC12A	9.70e-06	189	67	5	984b5f21e84dd8273d8437ac2a5a9de4e9484b9a
ToppCell	droplet-Lung-nan-3m-Myeloid-Classical_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NAPSA NFE2 TNFRSF1B CLEC12A	6.96e-05	146	67	4	ed932d43e9efd064ee4b49ddef529f3d041be765
ToppCell	droplet-Lung-nan-3m-Myeloid-classical_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NAPSA NFE2 TNFRSF1B CLEC12A	6.96e-05	146	67	4	0d74962779055c774312d59fc3b1365163741c3a
ToppCell	facs-Lung-Endomucin-24m-Myeloid-classical_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NAPSA NFE2 NYAP1 CLEC12A	8.34e-05	153	67	4	9c3220604b7fa4d91577b6c46960960f49644ca1
ToppCell	facs-Lung-Endomucin-24m-Myeloid-Classical_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NAPSA NFE2 NYAP1 CLEC12A	8.34e-05	153	67	4	ba624782693b0daa642e50881dbf5f0663fea82d
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-high_Fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	COL4A1 RINL ASAP1 MAP3K4	8.77e-05	155	67	4	82e602f31981c6b48abff2a04b2ab5d26d4462a2
ToppCell	TCGA-Breast-Primary_Tumor-Breast_Carcinoma-Infiltrating_Lobular_Carcinoma\|TCGA-Breast / Sample_Type by Project: Shred V9	PALD1 PRAM1 GIGYF1 PRAG1	8.77e-05	155	67	4	a4f2fffa8d0de760c556c3f8f1c91804eedbfa68
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-high_Fibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	COL4A1 RINL ASAP1 MAP3K4	8.77e-05	155	67	4	979c1d53b435a82c57d16707eed8ba7346326866
ToppCell	PND07-28-samps-Myeloid-Granulocyte-neutrophil__Lgals3-negative\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	NAPSA NFE2 TNFRSF1B CLEC12A	8.99e-05	156	67	4	166f7b1220eaf8e1149dde260dd85a094855c54f
ToppCell	PND07-28-samps-Myeloid-Granulocyte\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	NAPSA NFE2 TNFRSF1B CLEC12A	8.99e-05	156	67	4	5e1c5a7c9293b886920739cf766521df7f69726c
ToppCell	facs-Lung-EPCAM-3m-Myeloid-classical_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NAPSA NFE2 TNFRSF1B CLEC12A	9.45e-05	158	67	4	ef5feb48161c339c7b71c576bdda61479d29dfac
ToppCell	facs-Lung-EPCAM-3m-Myeloid-Classical_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NAPSA NFE2 TNFRSF1B CLEC12A	9.45e-05	158	67	4	c6e64b9b3342e37d54baadae8fb7dfb5d246e4cf
ToppCell	facs-Lung-Endomucin-24m-Myeloid\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NAPSA NFE2 TNFRSF1B CLEC12A	9.68e-05	159	67	4	886cbaef39a3517514a3896b6b960d01a3af043d
ToppCell	COVID_non-vent-Lymphocytic-Dendritic-pDC\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	PALD1 FLNB CUX2 AHNAK2	9.92e-05	160	67	4	61f4cb4eb4313d8318aadbb99595a6cb7fd919f7
ToppCell	COVID_non-vent-Lymphocytic-Dendritic\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	PALD1 FLNB CUX2 AHNAK2	9.92e-05	160	67	4	34b4f710cfcb6ec370b8b074f3cbfe272f392cec
ToppCell	facs-MAT-Fat-18m-Myeloid-myeloid_cell\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRAM1 NFE2 TNFRSF1B CLEC12A	9.92e-05	160	67	4	bd5fa7959bfe81011b8d798535b73ea1eee008b3
ToppCell	E18.5-Immune-Immune_Myeloid-Monocytic-Macrophage-iMON-iMON_prolif\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NFE2 TNFRSF1B RINL CLEC12A	9.92e-05	160	67	4	741e3b3f4ec5c77752da54746451f332435226e3
ToppCell	Control-B_intermediate-10\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	NETO1 CHD3 TNFRSF1B PRAG1	1.04e-04	162	67	4	aa80452b972bb8ad3670ffaba4ce26fadb33b185
ToppCell	facs-Thymus-Thymus_Flowthrough-18m\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TCF7 CHD3 GIGYF1 RINL	1.04e-04	162	67	4	7e6d20704d77b28512690f882f9ddbbd9c5c3228
ToppCell	facs-Thymus-Thymus_Flowthrough\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TCF7 CHD3 GIGYF1 RINL	1.04e-04	162	67	4	2c193f766f2cefe67682f34325d1de6aed778f49
ToppCell	ILEUM-non-inflamed-(3)_pDC\|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	FLNB CUX2 CLGN MEN1	1.07e-04	163	67	4	bc5411702badab39143905aa51676b4bbfad2041
ToppCell	droplet-Lung-3m-Hematologic-myeloid-non-classical_monocyte\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NAPSA NFE2 TNFRSF1B CLEC12A	1.07e-04	163	67	4	f6c8db5963ee1f8e0c2996f1aeecd58c00e9b099
ToppCell	10x5'-GI_large-bowel-Lymphocytic_T_CD4-Tfh\|GI_large-bowel / Manually curated celltypes from each tissue	TCF7 SETD1B AHDC1 ARID5A	1.07e-04	163	67	4	4104d3b9748b39cb0744c9be76db21bdda566a0d
ToppCell	droplet-Lung-3m-Hematologic-myeloid-non-classical_monocyte-nonclassical_monocyte_l4\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NAPSA NFE2 TNFRSF1B CLEC12A	1.09e-04	164	67	4	ea2897942ad72fba900c7ab354d6a9e203bf0e4a
ToppCell	facs-Lung-3m-Hematologic-myeloid\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NAPSA NFE2 TNFRSF1B CLEC12A	1.14e-04	166	67	4	7bf7c2854cf7d85b3ae07256bbe86ae9184d6b57
ToppCell	droplet-Lung-3m-Hematologic-myeloid-classical_monocyte-classical_monocyte_l2-17-52\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NFE2 ZFHX2 NYAP1 CLEC12A	1.14e-04	166	67	4	de319c960b0cd90b294f677d1ea1b013a2ce2d53
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-Mono-Mono_hypoxia-A\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	FLNB DUSP8 NIBAN2 TNFRSF1B	1.14e-04	166	67	4	ce570b768988e30898cf0387c2aa99989631f13f
ToppCell	10x5'-Liver-Myeloid_Dendritic-pDC\|Liver / Manually curated celltypes from each tissue	SHANK1 NAPSA FLNB CUX2	1.14e-04	166	67	4	24dfa9f3e0842f9ab8350bf6a52ae0d10f2a0c44
ToppCell	facs-Lung-3m-Hematologic-myeloid-classical_monocyte-classical_monocyte_l2\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NAPSA NFE2 TNFRSF1B CLEC12A	1.20e-04	168	67	4	ba9ddd403ee6d6af2fe56dffbd419764bfb703e4
ToppCell	facs-Lung-3m-Hematologic-myeloid-classical_monocyte\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NAPSA NFE2 TNFRSF1B CLEC12A	1.20e-04	168	67	4	af4c35c0d3f030cef8397c35fa498a71112bb16b
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Monocytic\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PALD1 PRAM1 TNFRSF1B CLEC12A	1.22e-04	169	67	4	b2fdf9f842dc7c181bc951a8a6932c916ed835ef
ToppCell	facs-Lung-EPCAM-24m-Myeloid-classical_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NAPSA NFE2 TNFRSF1B CLEC12A	1.22e-04	169	67	4	c934cf5b6decf6eee78243ee15c2a2c71e14cf71
ToppCell	facs-Lung-nan-3m-Myeloid-Classical_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NAPSA NFE2 TNFRSF1B CLEC12A	1.22e-04	169	67	4	05b138511039f1255a5f647040b1b9bdf222bd52
ToppCell	facs-Lung-nan-3m-Myeloid-classical_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NAPSA NFE2 TNFRSF1B CLEC12A	1.22e-04	169	67	4	bf0a97f53d6e3f9ffeaeae0402b010c49a6cccb7
ToppCell	droplet-Lung-21m-Hematologic-myeloid-non-classical_monocyte-nonclassical_monocyte_l4\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NAPSA NFE2 TNFRSF1B CLEC12A	1.22e-04	169	67	4	b059304543876f514d5c7214f1f0a2da00f10a67
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Monocytic-Monocyte-derived_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PALD1 PRAM1 TNFRSF1B CLEC12A	1.22e-04	169	67	4	2322f03a115c662f808ebfc892192b7d38d48181
ToppCell	droplet-Lung-21m-Hematologic-myeloid-non-classical_monocyte\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NAPSA NFE2 TNFRSF1B CLEC12A	1.22e-04	169	67	4	945f737984c4de70a4e9c214053b005358053dd5
ToppCell	tumor_Lymph_Node_/_Brain-B_lymphocytes-Plasma_cells\|B_lymphocytes / Location, Cell class and cell subclass	NAPSA NFE2 NIBAN2 USP54	1.22e-04	169	67	4	150c08c7b1dc0f46173a7b8f6a3fc70d82906c0d
ToppCell	facs-Lung-EPCAM-24m-Myeloid-Classical_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NAPSA NFE2 TNFRSF1B CLEC12A	1.22e-04	169	67	4	7503373fd9020c923e7eb96c7695f34054438e9e
ToppCell	facs-Lung-24m-Hematologic-myeloid-classical_monocyte-classical_monocyte_l2\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NAPSA NFE2 TNFRSF1B CLEC12A	1.22e-04	169	67	4	907e4c7d0df6dd46664d69834251aebca8e1dd1e
ToppCell	3'-Distal_airway-Immune_Myeloid-Myeloid_monocytic-classical_monocyte-Classical_monocytes-Classical_monocytes_L.1.2.0.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PRAM1 NFE2 TNFRSF1B CLEC12A	1.25e-04	170	67	4	3e52d40b0c36ab5b627a2dad025248901af8a320
ToppCell	droplet-Lung-1m-Hematologic-myeloid-intermediate_monocyte-intermediate_monocyte_l4\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NAPSA NFE2 TNFRSF1B CLEC12A	1.25e-04	170	67	4	4d28dc9eb572f43809619f923978cd7494853d43
ToppCell	droplet-Lung-1m-Hematologic-myeloid-intermediate_monocyte\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NAPSA NFE2 TNFRSF1B CLEC12A	1.28e-04	171	67	4	ed5886d6aa87b2d73469d39dc217227bd4d4c918
ToppCell	droplet-Lung-18m-Hematologic-myeloid\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NAPSA NFE2 TNFRSF1B CLEC12A	1.28e-04	171	67	4	33869b9fab2c94cb33f1cc659073fcf2bb30c22d
ToppCell	droplet-Lung-21m-Hematologic-myeloid\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NAPSA NFE2 TNFRSF1B CLEC12A	1.28e-04	171	67	4	22ad6de44e1d3f72a3d78d46fd26a5743a4f84a5
ToppCell	mild_COVID-19-pDC\|World / disease group, cell group and cell class (v2)	PALD1 FLNB CUX2 NYAP1	1.31e-04	172	67	4	dab2f1a05c7df58d9387b13271b3f1f1583f9ac3
ToppCell	MS-CD8-proli_CD4\|MS / Condition, Cell_class and T cell subcluster	FLNB MICAL3 USP54 CABIN1	1.31e-04	172	67	4	0b6dd257110b3f17fa71ab18a165b091a9d5ae9a
ToppCell	droplet-Lung-21m-Hematologic-myeloid-classical_monocyte\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NAPSA NFE2 TNFRSF1B CLEC12A	1.31e-04	172	67	4	a53c906539557594ef10368bc29aec4af063fd37
ToppCell	facs-Lung-24m-Hematologic-myeloid-classical_monocyte\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NAPSA NFE2 TNFRSF1B CLEC12A	1.31e-04	172	67	4	f557ec1b4d08b42559da02dd1f2387283c6380a2
ToppCell	droplet-Lung-LUNG-1m-Myeloid-classical_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NAPSA NFE2 TNFRSF1B CLEC12A	1.31e-04	172	67	4	07bf95ffe77347b4f3159cb88adeaddc1b4796b7
ToppCell	10x5'-lymph-node_spleen-Hematopoietic_progenitors-Cycling_pre-Myeloid-2\|lymph-node_spleen / Manually curated celltypes from each tissue	PRAM1 NFE2 NIBAN2 CLEC12A	1.34e-04	173	67	4	783b8fa08b9d8f597f251793eae164151662f1f9
ToppCell	droplet-Lung-21m-Hematologic-myeloid-classical_monocyte-classical_monocyte_l2\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NAPSA NFE2 TNFRSF1B CLEC12A	1.34e-04	173	67	4	9acad7ec70f713fe3db6cef7bbe3b183bf16ae67
ToppCell	CTRL-Lymphoid-pDC\|Lymphoid / Disease state, Lineage and Cell class	PALD1 FLNB CUX2 RRBP1	1.37e-04	174	67	4	ff4315e9fad198cc323fc987deb8652da137cf98
ToppCell	nucseq-Immune-Immune_Myeloid-Myeloid_Dendritic-pDC\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	PALD1 CUX2 ANKRD11 RRBP1	1.40e-04	175	67	4	37c2d4e0b6e9a3171931797ce9a54f3347288e57
ToppCell	facs-BAT-Fat-18m-Lymphocytic-T_cell\|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TCF7 CHD3 RINL ARID5A	1.40e-04	175	67	4	bf1ef77d5fed2135ac83a4f7e445ab59d1538696
ToppCell	facs-Limb_Muscle-Muscle_forelimb_and_hindlimb-18m\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NAPSA NFE2 GIGYF1 CLEC12A	1.40e-04	175	67	4	b4ff5a74ad22addbdd848dde9ba93d63a0611543
ToppCell	facs-Limb_Muscle-Muscle_forelimb_and_hindlimb\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NAPSA NFE2 GIGYF1 CLEC12A	1.40e-04	175	67	4	27a8c6e398638ccdee90c44e2ca6f59acc206cbc
ToppCell	droplet-Fat-Mat-18m-Hematologic-monocyte\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TDRD7 NFE2 CHD3 RINL	1.43e-04	176	67	4	867936a20f73f638055c19c8d88834aa2cc657cf
ToppCell	droplet-Spleen-nan-24m-Hematologic-proerythroblast\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NFE2 NIBAN2 TNFRSF1B CLEC12A	1.46e-04	177	67	4	5f20a1a875d6f85ec07b097e6afdb07c2f8f88ff
ToppCell	Severe-B_intermediate-10\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	NETO1 CHD3 TNFRSF1B PRAG1	1.49e-04	178	67	4	b7374a97c51239782bed658381a02cb1b3d9bf66
ToppCell	droplet-Liver-Npc-18m-Lymphocytic-macrophage/monocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NAPSA PHF2 NFE2 RINL	1.49e-04	178	67	4	09d2687e0d79f12e90af35fc1c0453d249cf2d19
ToppCell	facs-Diaphragm-Limb_Muscle-18m\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NAPSA NFE2 RINL CLEC12A	1.49e-04	178	67	4	40bd605b801d9ae76cffc8f62836092fc2b06812
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid-Dendritic-plasmacytoid_dendritic_cell\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	NAPSA PALD1 FLNB CUX2	1.53e-04	179	67	4	124da6f882968dc0d05f3edd8f3b4d61617cc214
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid-Dendritic-plasmacytoid_dendritic_cell-DC_c4-LILRA4\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	NAPSA PALD1 FLNB CUX2	1.53e-04	179	67	4	edc5ef693dc4e7ea70717b77fb908fc784dce3a2
ToppCell	facs-Thymus-Thymus_Flowthrough-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TCF7 CHD3 GIGYF1 RINL	1.56e-04	180	67	4	de87503d9caac3ebc80ab8090c1a9ee5a925b2a0
ToppCell	facs-Spleen-nan-18m-Lymphocytic-CD4-positive,_alpha-beta_T_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TCF7 CHD3 TNFRSF1B RINL	1.63e-04	182	67	4	fbe5bdd642b86010dbef0a567b25c69c7335688f
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Immune-Myeloid\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PALD1 PRAM1 TNFRSF1B CLEC12A	1.66e-04	183	67	4	a97f052950429245c3231464271e1ba539863bba
ToppCell	PCW_05-06-Hematologic_ErythroMegGranulo-Hem_Granulocytic-im_neutrophils_(9)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	PRAM1 NFE2 TNFRSF1B CLEC12A	1.66e-04	183	67	4	aed12b743334f3813db0c70d4fe7df90e0673f54
ToppCell	5'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating-Lymphatic_EC_differentiating_L.2.5.1.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	COL4A1 PALD1 NYAP1 ASAP1	1.66e-04	183	67	4	4d16bfbadf2cd13008c35e23dd2b5b4ecf92ee11
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Myeloid-Dendritic-plasmacytoid_dendritic_cell-DC_c4-LILRA4\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	NAPSA PALD1 FLNB CUX2	1.66e-04	183	67	4	3b123571e10c132227aff65648b4b3c6acb4bd00
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Myeloid-Dendritic-plasmacytoid_dendritic_cell\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	NAPSA PALD1 FLNB CUX2	1.66e-04	183	67	4	df6fd0927b6e4cf9a1583969a68096e4bccfbace
ToppCell	Mild/Remission-B_intermediate-10\|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)	NETO1 CHD3 TNFRSF1B PRAG1	1.66e-04	183	67	4	278064c9f0582463b83bf156d34e77f60187613b
ToppCell	AT1-AT2_cells-Donor_02\|World / lung cells shred on cell class, cell subclass, sample id	COL4A1 FLNB DUSP8 USP54	1.66e-04	183	67	4	6821dca076318115d360ff426eb1218cfe104063
ToppCell	10x5'-bone_marrow-Myeloid_Dendritic-pDC\|bone_marrow / Manually curated celltypes from each tissue	NAPSA PALD1 FLNB CUX2	1.70e-04	184	67	4	2817d530863e85dfdcd143b7a3dc5fc58a9cd98b
ToppCell	3'-Child04-06-SmallIntestine-Hematopoietic-Myeloid-Monocytes\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PRAM1 NFE2 TNFRSF1B CLEC12A	1.73e-04	185	67	4	00a991e63e9ac6de3f48a96e3be6073f90cbb442
ToppCell	facs-Marrow\|facs / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NAPSA PRAM1 NFE2 CLEC12A	1.73e-04	185	67	4	e40f0a0439834c3025d6c7832977be4e37a94c44
ToppCell	normal-na-Myeloid-plasmacytoid_dendritic_cell-male\|normal / PBMC cell types (v2) per disease, treatment status, and sex	PALD1 CUX2 PANX2 RRBP1	1.73e-04	185	67	4	3091870a5bf8ecb963e560b47c8502bae367416c
ToppCell	CF-Lymphoid-pDC\|Lymphoid / Disease state, Lineage and Cell class	PALD1 FLNB CUX2 RRBP1	1.81e-04	187	67	4	adc79e5804ab98006dbdf1d76ef0d8f85cc5cb0f
ToppCell	3'_v3-lymph-node_spleen-Myeloid_Dendritic-pDC\|lymph-node_spleen / Manually curated celltypes from each tissue	PALD1 FLNB CUX2 RRBP1	1.88e-04	189	67	4	6c2ace61a7d62bcf7e76b73e2da8b722d03e713b
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-Mono-Mono_naive-B\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	PRAM1 NFE2 TNFRSF1B CLEC12A	1.88e-04	189	67	4	55aba1ebc012006a5db3ff9c92589cb3d9f7c68a
ToppCell	Control-Other\|Control / Disease, Lineage and Cell Type	NAPSA FLNB PANX2 RRBP1	1.92e-04	190	67	4	3be5497909b48bf05c623586880f225bb101b430
ToppCell	PCW_05-06-Hematologic_ErythroMegGranulo-Hem_Granulocytic\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	PRAM1 NFE2 TNFRSF1B CLEC12A	1.92e-04	190	67	4	8e254fc77dd1d2d2a4ce0700af3c37829ca089bf
ToppCell	Control-Other-RBC\|Control / Disease, Lineage and Cell Type	NAPSA FLNB PANX2 RRBP1	1.92e-04	190	67	4	35b254564d01c839c63f9af159a46d368852cf15
ToppCell	myeloid-pDC\|World / Lineage and Cell class	PALD1 FLNB CUX2 RRBP1	1.92e-04	190	67	4	88c42779ce2f817d28e672d83f3f1158581edf73
ToppCell	PND10\|World / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	COL4A1 ANKRD11 RRBP1 AFF4	1.92e-04	190	67	4	d67e2814047c8df2ae4b7bc8be9539f5df6ecef2
ToppCell	3'_v3-bone_marrow-Myeloid_Dendritic-pDC\|bone_marrow / Manually curated celltypes from each tissue	PALD1 FLNB CUX2 RRBP1	1.92e-04	190	67	4	dde0e34f6a06cdbbb65c86472360c09f0279a572
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Myeloid_monocytic-classical_monocyte-Classical_monocytes-Classical_monocytes_L.1.2.0.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PRAM1 NFE2 TNFRSF1B CLEC12A	1.96e-04	191	67	4	5d6ef70cc15ec5e983a953e547e40f9c06e355fb
ToppCell	RA-09._Endothelium_I\|World / Chamber and Cluster_Paper	FLNB NETO1 PRAG1 ASAP1	1.96e-04	191	67	4	c8a0c2af119bc34a8f694a7d30642f28002c84b9
ToppCell	10x_3'_v3-bone_marrow_(10x_3'_v3)\|10x_3'_v3 / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	CRACD PRAM1 NFE2 CLEC12A	2.00e-04	192	67	4	072281344d58e85c9a290750b488d0c101f75d54
ToppCell	Nasal_Brush-Immune-Neutrophils\|Nasal_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X	PRAM1 NFE2 TNFRSF1B CLEC12A	2.00e-04	192	67	4	20a7f7beb01df1c4f915ec2f9b5a9dbcab157187
Drug	Indapamide [26807-65-8]; Down 200; 10.6uM; PC3; HT_HG-U133A	WIZ CYP3A4 NAB2 CABIN1 AGRN AHDC1 AFF4	1.65e-06	194	67	7	4335_DN
Drug	Neostigmine bromide [114-80-7]; Down 200; 13.2uM; MCF7; HT_HG-U133A	SETD1B CYP3A4 CHD3 RRBP1 CABIN1 PRRC2A AFF4	1.89e-06	198	67	7	5335_DN
Drug	Minocycline hydrochloride [13614-98-7]; Down 200; 8uM; MCF7; HT_HG-U133A	SETD1B MTOR NAB2 BAZ1B RPUSD2 CILK1 CABIN1	1.96e-06	199	67	7	7436_DN
Drug	Imatinib Mesylate	CYP3A7 CYP3A4 MTOR NAB2 TNFRSF1B CDK4	3.71e-06	141	67	6	ctd:D000068877
Drug	pirifibrate	CYP3A4 NETO1	8.53e-06	2	67	2	CID000068720
Drug	bromide	SLC5A5 SHANK1 CYP3A7 CUX2 SYT3 CYP3A4 CDK4	1.35e-05	267	67	7	CID000000259
Drug	AC1O745K	SLC5A5 CYP3A4 MTOR CDK4	1.42e-05	50	67	4	CID006518178
Drug	Ethisterone [434-03-7]; Down 200; 12.8uM; PC3; HT_HG-U133A	SLC5A5 WIZ NAB2 AGRN ARID5A CAPN15	2.04e-05	190	67	6	4340_DN
Drug	(+) -Levobunolol hydrochloride [47141-41-3]; Down 200; 12.2uM; MCF7; HT_HG-U133A	CLGN CYP3A4 NAB2 MICAL3 SNAPC4 CAPN15	2.36e-05	195	67	6	4980_DN
Drug	Pentylenetetrazole [54-95-5]; Down 200; 29uM; MCF7; HT_HG-U133A	CYP3A4 DUSP8 CHD3 SNAPC4 CABIN1 AHNAK2	2.36e-05	195	67	6	2255_DN
Drug	Hesperidin [520-26-3]; Down 200; 6.6uM; MCF7; HT_HG-U133A	PHF2 TCF7 NAB2 EDC4 SNAPC4 RRBP1	2.36e-05	195	67	6	5313_DN
Drug	Cotinine (-) [486-56-6]; Down 200; 22.6uM; MCF7; HT_HG-U133A	SETD1B DUSP8 BAZ1B CHD3 RRBP1 AGRN	2.43e-05	196	67	6	1511_DN
Drug	Naltrexone hydrochloride dihydrate [16676-29-2]; Up 200; 9.6uM; MCF7; HT_HG-U133A	SLC5A5 COL4A1 BAZ1B CILK1 CABIN1 AHDC1	2.50e-05	197	67	6	6241_UP
Drug	0316684-0000 [391209-55-5]; Up 200; 10uM; MCF7; HT_HG-U133A	WIZ DUSP8 SNAPC4 CABIN1 AGRN AHDC1	2.50e-05	197	67	6	7052_UP
Drug	17-hydroxypregnenolone sulfate	CYP3A7 CYP3A4	2.55e-05	3	67	2	CID000152971
Drug	Biotin [58-85-5]; Down 200; 16.4uM; MCF7; HT_HG-U133A	TCF7 CLGN WIZ NAB2 BAZ1B CAPN15	2.57e-05	198	67	6	3289_DN
Drug	(S)-(-)-Atenolol [93379-54-5]; Down 200; 15uM; MCF7; HT_HG-U133A	CYP3A4 NAB2 BAZ1B CABIN1 AHDC1 CAPN15	2.57e-05	198	67	6	5325_DN
Drug	THIP Hydrochloride; Down 200; 22.6uM; MCF7; HT_HG-U133A	WIZ CYP3A4 NAB2 RRBP1 AHDC1 CAPN15	2.65e-05	199	67	6	6511_DN
Drug	Ungerine nitrate; Down 200; 10.2uM; MCF7; HT_HG-U133A	TCF7 DUSP8 CHD3 CABIN1 PRRC2A AHDC1	2.65e-05	199	67	6	7173_DN
Drug	Tetracaone hydrochloride [136-47-0]; Down 200; 13.2uM; MCF7; HT_HG-U133A	CYP3A4 MTOR NAB2 BAZ1B RPUSD2 RRBP1	2.65e-05	199	67	6	7473_DN
Drug	Proadifen hydrochloride [62-68-0]; Down 200; 10.2uM; MCF7; HT_HG-U133A	PHF2 WIZ SNAPC4 RRBP1 CABIN1 CAPN15	2.72e-05	200	67	6	7165_DN
Drug	Saquinavir mesylate [149845-06-7]; Up 200; 5.2uM; MCF7; HT_HG-U133A	COL4A1 WIZ BAZ1B CHD3 RRBP1 CABIN1	2.72e-05	200	67	6	6246_UP
Drug	tetraarsenic tetrasulfide	PRAM1 MTOR TNFRSF1B CDK4	2.95e-05	60	67	4	ctd:C534735
Drug	cyclophorine	COL4A1 CYP3A7 CYP3A4 NETO1 MTOR CILK1 TNFRSF1B CABIN1	3.49e-05	426	67	8	CID000002909
Drug	azidopine	CYP3A4 CILK1 CABIN1	7.57e-05	28	67	3	CID000656406
Drug	SR-12813	CYP3A7 CYP3A4 NETO1	8.43e-05	29	67	3	CID000446313
Drug	1,2-DAA	TNFRSF1B AGRN	8.48e-05	5	67	2	CID000015652
Drug	AC1O745W	CYP3A4 MTOR CABIN1	1.14e-04	32	67	3	CID006518184
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A	PHF2 SETD1B RRBP1 MAP3K4 CAPN15	1.19e-04	163	67	5	7453_DN
Drug	Alfentanil	CYP3A7 CYP3A4	1.27e-04	6	67	2	ctd:D015760
Drug	squalestatin	CYP3A4 NETO1 CDK4	1.37e-04	34	67	3	CID006438355
Drug	NSC717865	CYP3A7 CYP3A4 MTOR TNFRSF1B CABIN1 AGRN CDK4	1.40e-04	387	67	7	CID000005372
Drug	thiazolidinedione	SLC5A5 CYP3A4 NETO1 NFE2 MTOR CDK4	1.55e-04	274	67	6	CID000005437
Drug	triphenyltetrazolium chloride	CYP3A4 BAZ1B CABIN1 MEN1	1.58e-04	92	67	4	CID000009283
Drug	Bortezomib	TCF7 SETD1B CYP3A4 NAB2 CILK1 PANX2 AGRN AFF4 ASAP1 CAPN15	1.60e-04	838	67	10	ctd:D000069286
Drug	NSC648766	CYP3A7 CYP3A4 MTOR TNFRSF1B	1.64e-04	93	67	4	CID000003199
Drug	3-(2-(dimethylamino)isopropoxy)-1-hydroxybenzo(b)naphtho(2,3-d)furan-6,11-dione	MTOR CDK4	1.77e-04	7	67	2	ctd:C560905
Drug	covellite	SLC5A5 CUX2	1.77e-04	7	67	2	CID000014831
Drug	AC1L1KIN	CYP3A7 CYP3A4 NETO1 TNFRSF1B	2.17e-04	100	67	4	CID000005516
Drug	chlorpyrifos	CYP3A7 CYP3A4 NETO1 CILK1	2.26e-04	101	67	4	CID000002730
Drug	genistein; Down 200; 10uM; HL60; HT_HG-U133A	FLNB TCF7 WIZ NFE2 SNAPC4	2.32e-04	188	67	5	1176_DN
Drug	3-hydroxycarbamazepine	CYP3A7 CYP3A4	2.36e-04	8	67	2	CID000135290
Drug	retinoic acid; Down 200; 1uM; HL60; HT_HG-U133A	MICAL3 SNAPC4 RRBP1 MYO15A AGRN	2.38e-04	189	67	5	6170_DN
Drug	retinoic acid; Down 200; 1uM; MCF7; HT_HG-U133A	TCF7 NAB2 BAZ1B SNAPC4 CABIN1	2.38e-04	189	67	5	5208_DN
Drug	colcemid; Up 200; 11.7uM; MCF7; HT_HG-U133A_EA	PHF2 DUSP8 AGRN PRRC2A CAPN15	2.44e-04	190	67	5	1103_UP
Drug	C75; Down 200; 10uM; PC3; HT_HG-U133A	PHF2 WIZ CYP3A4 ZFHX2 CABIN1	2.50e-04	191	67	5	6399_DN
Drug	Danazol [17230-88-5]; Down 200; 11.8uM; HL60; HG-U133A	NFE2 RPUSD2 SNAPC4 CABIN1 SGF29	2.50e-04	191	67	5	2038_DN
Drug	Rapamycin; Down 200; 0.1uM; MCF7; HT_HG-U133A	TCF7 WIZ DUSP8 BAZ1B RRBP1	2.50e-04	191	67	5	5567_DN
Drug	PHA-00851261E [724719-49-7]; Down 200; 10uM; PC3; HT_HG-U133A	PHF2 SNAPC4 CABIN1 AGRN AHDC1	2.56e-04	192	67	5	4330_DN
Drug	Cefalonium [5575-21-3]; Down 200; 8.8uM; PC3; HT_HG-U133A	WIZ MYO15A CABIN1 AGRN CAPN15	2.62e-04	193	67	5	4245_DN
Drug	5155877; Down 200; 10uM; MCF7; HT_HG-U133A	TCF7 CYP3A4 RPUSD2 SNAPC4 AGRN	2.62e-04	193	67	5	6574_DN
Drug	Isoquinoline, 6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydro, hydrochloride; Down 200; 16.4uM; MCF7; HT_HG-U133A	FLNB CILK1 SNAPC4 CABIN1 PRRC2A	2.68e-04	194	67	5	2824_DN
Drug	Dirithromycin [62013-04-1]; Down 200; 4.8uM; HL60; HG-U133A	PHF2 FLNB CABIN1 SGF29 CAPN15	2.68e-04	194	67	5	1712_DN
Drug	Benzethonium chloride [121-54-0]; Down 200; 9uM; MCF7; HT_HG-U133A	WIZ CYP3A4 SNAPC4 CABIN1 CAPN15	2.68e-04	194	67	5	6070_DN
Drug	Mefenamic acid [61-68-7]; Down 200; 16.6uM; MCF7; HT_HG-U133A	CILK1 CHD3 RRBP1 AHDC1 CAPN15	2.68e-04	194	67	5	1699_DN
Drug	radicicol, diheterospora chlamydosporia; Down 200; 0.1uM; MCF7; HT_HG-U133A	RPUSD2 SNAPC4 RRBP1 AHDC1 CAPN15	2.68e-04	194	67	5	5216_DN
Drug	Mecamylamine hydrochloride [826-39-1]; Down 200; 19.6uM; MCF7; HT_HG-U133A	TCF7 BAZ1B MICAL3 CABIN1 CAPN15	2.75e-04	195	67	5	3525_DN
Drug	Bumetanide [28395-03-1]; Down 200; 11uM; HL60; HT_HG-U133A	TCF7 CYP3A4 PRRC2A AHDC1 CAPN15	2.75e-04	195	67	5	2409_DN
Drug	Podophyllotoxin [518-28-5]; Down 200; 9.6uM; MCF7; HT_HG-U133A	TCF7 WIZ NAB2 BAZ1B PRRC2A	2.75e-04	195	67	5	7198_DN
Drug	Betulinic acid [472-15-1]; Up 200; 8.8uM; HL60; HT_HG-U133A	CYP3A4 NAB2 CILK1 EDC4 CAPN15	2.75e-04	195	67	5	1345_UP
Drug	haloperidol; Down 200; 10uM; HL60; HT_HG-U133A	FLNB WIZ SNAPC4 CABIN1 ARID5A	2.75e-04	195	67	5	1144_DN
Drug	quercetin dihydrate; Up 200; 1uM; MCF7; HG-U133A	WIZ RPUSD2 RRBP1 CABIN1 AGRN	2.81e-04	196	67	5	283_UP
Drug	haloperidol; Down 200; 10uM; MCF7; HT_HG-U133A	SLC5A5 WIZ CYP3A4 ZFHX2 CABIN1	2.81e-04	196	67	5	5604_DN
Drug	Epiandrosterone [481-29-8]; Down 200; 13.8uM; MCF7; HT_HG-U133A	SETD1B WIZ CYP3A4 CHD3 RRBP1	2.81e-04	196	67	5	3306_DN
Drug	Pyrimethamine [58-14-0]; Down 200; 16uM; MCF7; HT_HG-U133A	WIZ CYP3A4 SNAPC4 CABIN1 CAPN15	2.81e-04	196	67	5	4779_DN
Drug	Ivermectin [70288-86-7]; Down 200; 4.6uM; PC3; HT_HG-U133A	RPUSD2 EDC4 SNAPC4 RRBP1 PRRC2A	2.81e-04	196	67	5	2051_DN
Drug	Domperidone maleate; Down 200; 7.4uM; HL60; HT_HG-U133A	TCF7 DUSP8 CHD3 EDC4 CAPN15	2.81e-04	196	67	5	1301_DN
Drug	0173570-0000 [211245-44-2]; Down 200; 1uM; PC3; HT_HG-U133A	RPUSD2 MICAL3 SGF29 AHDC1 CAPN15	2.81e-04	196	67	5	7391_DN
Drug	Chenodiol [474-25-9]; Up 200; 10.2uM; PC3; HT_HG-U133A	DUSP8 BAZ1B SNAPC4 RRBP1 AFF4	2.81e-04	196	67	5	7310_UP
Drug	Zardaverine [101975-10-4]; Down 200; 15uM; MCF7; HT_HG-U133A	NAB2 RRBP1 SGF29 AHDC1 CAPN15	2.81e-04	196	67	5	4793_DN
Drug	Adamantamine fumarate [80789-67-9]; Up 200; 9.6uM; HL60; HT_HG-U133A	WIZ BAZ1B ZFHX2 CHD3 CAPN15	2.81e-04	196	67	5	1344_UP
Drug	Ethamsylate [2624-44-4]; Down 200; 15.2uM; MCF7; HT_HG-U133A	WIZ EDC4 RRBP1 CABIN1 AHDC1	2.88e-04	197	67	5	7335_DN
Drug	N-Acetyl-DL-homocysteine Thiolactone [1195-16-0]; Down 200; 25.2uM; MCF7; HT_HG-U133A	WIZ CYP3A4 SNAPC4 RRBP1 AHNAK2	2.88e-04	197	67	5	3930_DN
Drug	Folic acid [59-30-3]; Down 200; 9uM; MCF7; HT_HG-U133A	FLNB BAZ1B SNAPC4 ASAP1 CAPN15	2.88e-04	197	67	5	7201_DN
Drug	Naringenine [480-41-1]; Down 200; 14.6uM; HL60; HT_HG-U133A	FLNB WIZ NFE2 BAZ1B PRRC2A	2.88e-04	197	67	5	1342_DN
Drug	CP-645525-01 [287190-82-3]; Down 200; 10uM; MCF7; HT_HG-U133A	WIZ MTOR SNAPC4 RRBP1 AHNAK2	2.88e-04	197	67	5	7522_DN
Drug	Ticarcillin sodium [4697-14-7]; Down 200; 9.4uM; MCF7; HT_HG-U133A	WIZ CHD3 RRBP1 CABIN1 CAPN15	2.88e-04	197	67	5	7185_DN
Drug	Mephenesin [59-47-2]; Down 200; 22uM; PC3; HT_HG-U133A	WIZ BAZ1B SNAPC4 SGF29 CAPN15	2.88e-04	197	67	5	7374_DN
Drug	17-DMAG; Down 200; 0.1uM; HL60; HT_HG-U133A	FLNB NFE2 EDC4 SNAPC4 CAPN15	2.88e-04	197	67	5	1154_DN
Drug	Ketoconazole [65277-42-1]; Down 200; 7.6uM; MCF7; HT_HG-U133A	TCF7 DUSP8 BAZ1B SNAPC4 RRBP1	2.88e-04	197	67	5	5685_DN
Drug	Triamterene [396-01-0]; Down 200; 15.8uM; MCF7; HT_HG-U133A	FLNB BAZ1B RRBP1 AGRN CAPN15	2.88e-04	197	67	5	1697_DN
Drug	Gallamine triethiodide [65-29-2]; Down 200; 4.4uM; PC3; HT_HG-U133A	MTOR DUSP8 CHD3 SGF29 PRRC2A	2.88e-04	197	67	5	2059_DN
Drug	Cloxacillin sodium salt [642-78-4]; Down 200; 8.8uM; MCF7; HT_HG-U133A	CYP3A4 BAZ1B RPUSD2 RRBP1 AFF4	2.88e-04	197	67	5	7483_DN
Drug	Doxycycline hydrochloride [10592-13-9]; Down 200; 8.4uM; MCF7; HT_HG-U133A	TCF7 NAB2 DUSP8 RRBP1 PRRC2A	2.88e-04	197	67	5	7195_DN
Drug	Pyridoxine hydrochloride [58-56-0]; Down 200; 19.4uM; MCF7; HT_HG-U133A	TCF7 DUSP8 SNAPC4 RRBP1 CAPN15	2.88e-04	197	67	5	7171_DN
Drug	Azaperone [1649-18-9]; Down 200; 12.2uM; MCF7; HT_HG-U133A	MTOR NAB2 MICAL3 CHD3 CAPN15	2.88e-04	197	67	5	7231_DN
Drug	S(-)-terguride hydrogen maleate [37686-85-4]; Down 200; 8.8uM; MCF7; HT_HG-U133A	TDRD7 CYP3A4 BAZ1B MICAL3 RRBP1	2.95e-04	198	67	5	6473_DN
Drug	Leflunomide [75706-12-6]; Down 200; 14.8uM; MCF7; HT_HG-U133A	NAB2 MICAL3 SNAPC4 AHDC1 CAPN15	2.95e-04	198	67	5	7238_DN
Drug	Tomatidine [77-59-8]; Up 200; 9.6uM; HL60; HG-U133A	NAB2 DUSP8 ZFHX2 SNAPC4 AGRN	2.95e-04	198	67	5	1754_UP
Drug	Iopamidol [60166-93-0]; Down 200; 5.2uM; MCF7; HT_HG-U133A	TCF7 NAB2 BAZ1B CHD3 PRRC2A	2.95e-04	198	67	5	7189_DN
Drug	Guanethidine sulfate [60-02-6]; Down 200; 13.4uM; PC3; HT_HG-U133A	CYP3A4 NAB2 ZFHX2 CABIN1 CAPN15	2.95e-04	198	67	5	5731_DN
Drug	Metanephrine hydrochloride DL [881-95-8]; Down 200; 17.2uM; MCF7; HT_HG-U133A	TCF7 NAB2 DUSP8 SNAPC4 CABIN1	2.95e-04	198	67	5	5334_DN
Drug	Moxalactam disodium salt [64953-12-4]; Down 200; 7uM; MCF7; HT_HG-U133A	SLC5A5 BAZ1B CABIN1 AFF4 CAPN15	2.95e-04	198	67	5	5609_DN
Drug	Benzydamine hydrochloride [132-69-4]; Down 200; 11.6uM; MCF7; HT_HG-U133A	TCF7 WIZ DUSP8 CHD3 SNAPC4	2.95e-04	198	67	5	7169_DN
Drug	Hydroquinine hydrobromide hydrate [304695-81-6]; Down 200; 9.4uM; MCF7; HT_HG-U133A	CYP3A4 CHD3 CABIN1 AGRN AHDC1	2.95e-04	198	67	5	2767_DN
Drug	Pyrazinamide [ 98-96-4]; Down 200; 32.4uM; MCF7; HT_HG-U133A	TCF7 CYP3A4 MTOR NAB2 RRBP1	2.95e-04	198	67	5	4962_DN
Drug	Propantheline bromide [50-34-0]; Down 200; 9uM; HL60; HT_HG-U133A	FLNB CLGN WIZ NAB2 CAPN15	2.95e-04	198	67	5	3013_DN
Drug	Ranitidine hydrochloride [66357-59-3]; Down 200; 11.4uM; MCF7; HT_HG-U133A	NAB2 BAZ1B MICAL3 CABIN1 AHNAK2	2.95e-04	198	67	5	2251_DN
Drug	sulfaphenazole	FLNB CYP3A7 CYP3A4	2.96e-04	44	67	3	CID000005335
Drug	Fusidic acid sodium salt [751-94-0]; Down 200; 7.4uM; MCF7; HT_HG-U133A	TCF7 SETD1B BAZ1B CILK1 AFF4	3.02e-04	199	67	5	5353_DN
Disease	tacrolimus measurement	CYP3A7 CYP3A4	2.95e-05	4	66	2	EFO_0008458
Disease	estrone conjugate measurement	CYP3A7 CYP3A4	2.95e-05	4	66	2	EFO_0007971
Disease	Sezary Syndrome	KMT2D CHD3 TNFRSF1B	3.01e-05	27	66	3	C0036920
Disease	tauro-beta-muricholate measurement	CYP3A7 CYP3A4	4.91e-05	5	66	2	EFO_0800213
Disease	glyco-beta-muricholate measurement	CYP3A7 CYP3A4	4.91e-05	5	66	2	EFO_0800569
Disease	dehydroisoandrosterone sulfate DHEA-S measurement	CYP3A7 CYP3A4	7.35e-05	6	66	2	EFO_0021119
Disease	androstenediol (3beta,17beta) monosulfate (1) measurement	CYP3A7 CYP3A4	7.35e-05	6	66	2	EFO_0800294
Disease	Congenital cataract	TDRD7 COL4A1	7.35e-05	6	66	2	C0009691
Disease	X-24574 measurement	CYP3A7 CYP3A4	1.03e-04	7	66	2	EFO_0800897
Disease	androstenediol (3beta,17beta) disulfate (1) measurement	CYP3A7 CYP3A4	1.76e-04	9	66	2	EFO_0800278
Disease	4-androsten-3alpha,17alpha-diol monosulfate (3) measurement	CYP3A7 CYP3A4	2.19e-04	10	66	2	EFO_0022090
Disease	5alpha-androstan-3beta,17alpha-diol disulfate measurement	CYP3A7 CYP3A4	2.19e-04	10	66	2	EFO_0800289
Disease	DNA repair protein RAD51 homolog 4 measurement	CYP3A7 CYP3A4	2.68e-04	11	66	2	EFO_0801531
Disease	androstenediol (3beta,17beta) monosulfate (2) measurement	CYP3A7 CYP3A4	2.68e-04	11	66	2	EFO_0800295
Disease	5alpha-androstan-3beta,17beta-diol monosulfate (2) measurement	CYP3A7 CYP3A4	3.21e-04	12	66	2	EFO_0800291
Disease	colon carcinoma (is_marker_for)	KMT2D TNFRSF1B	3.78e-04	13	66	2	DOID:1520 (is_marker_for)
Disease	androstenediol (3alpha, 17alpha) monosulfate (3) measurement	CYP3A7 CYP3A4	3.78e-04	13	66	2	EFO_0800293
Disease	5alpha-pregnan-3beta,20beta-diol monosulfate (1) measurement	CYP3A7 CYP3A4	3.78e-04	13	66	2	EFO_0800284
Disease	X-21470 measurement	CYP3A7 CYP3A4	4.41e-04	14	66	2	EFO_0800817
Disease	5alpha-androstan-3alpha,17alpha-diol monosulfate measurement	CYP3A7 CYP3A4	4.41e-04	14	66	2	EFO_0800283
Disease	16a-hydroxy DHEA 3-sulfate measurement	CYP3A7 CYP3A4	5.08e-04	15	66	2	EFO_0800301
Disease	X-21410 measurement	CYP3A7 CYP3A4	5.79e-04	16	66	2	EFO_0800813
Disease	andro steroid monosulfate C19H28O6S (1) measurement	CYP3A7 CYP3A4	5.79e-04	16	66	2	EFO_0800305
Disease	Malignant neoplasm of breast	SLC5A5 FLNB KMT2D SYT3 CYP3A4 MTOR USP54 PANX2 PRRC2A	6.23e-04	1074	66	9	C0006142
Disease	superior frontal gyrus volume measurement	PALD1 SYT3	7.37e-04	18	66	2	EFO_0010329
Disease	5alpha-androstan-3alpha,17beta-diol monosulfate (1) measurement	CYP3A7 CYP3A4	7.37e-04	18	66	2	EFO_0800288
Disease	metabolonic lactone sulfate measurement	CYP3A7 CYP3A4	8.22e-04	19	66	2	EFO_0800659
Disease	etiocholanolone glucuronide measurement	CYP3A7 CYP3A4	8.22e-04	19	66	2	EFO_0800362
Disease	androsterone glucuronide measurement	CYP3A7 CYP3A4	9.12e-04	20	66	2	EFO_0800317
Disease	X-24947 measurement	CYP3A7 CYP3A4	1.11e-03	22	66	2	EFO_0800910
Disease	5alpha-androstan-3beta,17beta-diol disulfate measurement	CYP3A7 CYP3A4	1.11e-03	22	66	2	EFO_0021115
Disease	Hereditary Paraganglioma-Pheochromocytoma Syndrome	KMT2D MEN1	1.21e-03	23	66	2	C1708353
Disease	serum non-albumin protein measurement	COL4A1 CUX2 TCF7 SGF29 PRRC2A	1.29e-03	361	66	5	EFO_0004568
Disease	C-reactive protein measurement	CYP3A7 CUX2 CYP3A4 BAZ1B MICAL3 CCDC168 SNAPC4 PRAG1 AFF4	1.41e-03	1206	66	9	EFO_0004458
Disease	epiandrosterone sulfate measurement	CYP3A7 CYP3A4	1.43e-03	25	66	2	EFO_0021120
Disease	FEV/FEC ratio	COL4A1 PHF2 NRBF2 NETO1 ANKRD11 MICAL3 RRBP1 MYO15A ASAP1	1.59e-03	1228	66	9	EFO_0004713
Disease	lung small cell carcinoma (is_implicated_in)	KMT2D MTOR	1.79e-03	28	66	2	DOID:5409 (is_implicated_in)
Disease	urinary metabolite measurement	CYP3A7 CYP3A4 CABIN1 SGF29	2.23e-03	245	66	4	EFO_0005116

Protein segments in the cluster

Peptide	Gene	Start	Entry
LLGPPGKEGLSVKEP	ARID5A	371	Q03989
DIPAKKPPGLDPPFK	ANKRD11	1636	Q6UB99
PGPPDPGEAPKLCKL	DUSP8	411	Q13202
GRKPFPLVKPLPGEE	BAZ1B	6	Q9UIG0
VPPGEPLEIKGAKKP	ALDH1L2	276	Q3SY69
LGGLPELPVGPALPK	AGRN	2016	O00468
PKNLLLGPGKPKEPA	AHDC1	551	Q5TGY3
PGNDGLPKVAPGPLL	CUX2	1336	O14529
AKEKDLLPSPAGPVP	AFF4	806	Q9UHB7
LPGPKGEPGKIVPLP	COL4A1	631	P02462
PDPDFKDLGALKPLP	NETO1	156	Q8TDF5
LPGLLPAPADKLTPK	EDC4	681	Q6P2E9
LLPGKAVDLGPPKPS	NIBAN2	701	Q96TA1
LKAHLSEPPPGKEGP	PALD1	581	Q9ULE6
EPPPPKKPALDKGLG	MEN1	496	O00255
VLPKPPAILGEPKGS	CAPN15	86	O75808
PKRLGLPKPEGEPLS	MICAL3	1386	Q7RTP6
AFLPLKKGPKEPIPE	GIGYF1	311	O75420
LAPIRAPEPLPKGGE	MYO15A	1091	Q9UKN7
KSPLELGEKLSPLPG	NAB2	161	Q15742
GLFKKLGIPGPTPLP	CYP3A4	31	P08684
LPPDPSKVKAHGPGL	FLNB	1036	O75369
PKLPPPEDISGILKE	POU5F2	111	Q8N7G0
VEPPGDKTLKPGPGA	ODF3	206	Q96PU9
GKAKDIPIPNLPPLD	NRBF2	251	Q96F24
EGLPQPKKPPLADGS	CABIN1	1701	Q9Y6J0
KAPPPGLPAETIKDL	CDK4	106	P11802
EKDKPLPPLLARVGG	CHD3	1391	Q12873
PPPAGVRELGKGPEK	CRACD	761	Q6ZU35
LAPKPQIGDLPPKPG	ASAP1	946	Q9ULH1
QIGDLPPKPGELPPK	ASAP1	951	Q9ULH1
ENDIKVLGGPKIPPP	CCDC168	1546	Q8NDH2
GLFKKLGIPGPTPLP	CYP3A7	31	P24462
GLAPAPIKDAPLPEK	PANX2	556	Q96RD6
LLDIGLPAGPPKPQE	NFE2	126	Q16621
PAGPPLGAGEPKTEK	NYAP1	476	Q6ZVC0
LKLKDPDPDPNPGVI	MTOR	781	P42345
GHKPPIPERLSPEGK	MAP3K4	1561	Q9Y6R4
GDAKVELSPGPPKPA	RPUSD2	61	Q8IZ73
PALPLPLPGGEEKAK	SYT3	251	Q9BQG1
PILVPKKDGLGLAVP	PHF2	126	O75151
KDPGKSLPPVPPMGL	TBC1D25	591	Q3MII6
PLPHDSPLIEKPGLG	NBR1	591	Q14596
PGLLPEAPSKPGLPK	GPR108	141	Q9NPR9
ALSKKPPQPELGGLP	PRAM1	316	Q96QH2
KEPLKEKLIPGPLSP	PRRC2A	1206	P48634
GDKEAPPPVLLTPKA	PRRC2A	1336	P48634
PLPPAEPLAKEKPGT	SETD1B	436	Q9UPS6
LAKKLPPPPGSPLGH	WIZ	1136	O95785
LDTEKVPLSPLPGPK	TDRD7	311	Q8NHU6
LLSLPPDKPFGAKPL	SHANK1	2081	Q9Y566
VKLPEGPLPEGASLK	AHNAK2	741	Q8IVF2
EKPQKGILEKAGPPP	CILK1	301	Q9UPZ9
GSLLEDVVPPIKPPK	CLGN	251	O14967
IPEIGKFGEKAPPAP	CLEC12A	21	Q5QGZ9
GPGLPKKDEDPGPAL	RINL	331	Q6ZS11
PLAGPGLRPDKPLEA	ZFHX2	646	Q9C0A1
EKGPTLLKHPPAPAE	RRBP1	1091	Q9P2E9
PEELPTGNKKPPGFL	SLC5A5	591	Q92911
KPGDKPPPLCGAIPA	SGF29	136	Q96ES7
LDPLKSHKPEPPVAG	WDR70	556	Q9NW82
APGKLPLPKQEDAPV	PRAG1	116	Q86YV5
PDKLPEPLEDGLKAP	TCF7	96	P36402
LDEKPLDLGPPLPPK	ZDHHC8	306	Q9ULC8
LDLGPPLPPKIEAGT	ZDHHC8	311	Q9ULC8
GPEKGALDLEKPPLP	SNAPC4	1246	Q5SXM2
KPPLPQPGPEKGALD	SNAPC4	1256	Q5SXM2
EKPLPLGVPDAGMKP	TNFRSF1B	446	P20333
IKPKELEGLPPGAKV	ZNF280C	496	Q8ND82
GGDQPDKKPPRTLPL	USP54	536	Q70EL1
PKEPGPLQCEAKPLG	KMT2D	406	O14686
RGLAVPDGPLGLPPK	KIAA1522	451	Q9P206
AELPKLGAPSPGDKP	NAPSA	51	O96009