Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	3',5'-cyclic-AMP phosphodiesterase activity	PDE4A PDE4B PDE4C PDE4D	1.01e-05	22	126	4	GO:0004115
GeneOntologyMolecularFunction	3',5'-cyclic-GMP phosphodiesterase activity	PDE4A PDE4B PDE4C PDE4D	1.46e-05	24	126	4	GO:0047555
GeneOntologyMolecularFunction	3',5'-cyclic-nucleotide phosphodiesterase activity	PDE4A PDE4B PDE4C PDE4D	1.73e-05	25	126	4	GO:0004114
GeneOntologyMolecularFunction	cAMP binding	PDE4A PDE4B PDE4D CNGA4	1.73e-05	25	126	4	GO:0030552
GeneOntologyMolecularFunction	cyclic-nucleotide phosphodiesterase activity	PDE4A PDE4B PDE4C PDE4D	2.37e-05	27	126	4	GO:0004112
GeneOntologyMolecularFunction	nucleoside-triphosphatase regulator activity	DOCK3 IQGAP2 TBC1D5 ARHGAP35 RGL1 DENND10 ARHGEF7 PLEKHG3 SGSM2 AGAP7P AGAP4 AGAP6	8.92e-05	507	126	12	GO:0060589
GeneOntologyMolecularFunction	GTPase regulator activity	DOCK3 IQGAP2 TBC1D5 ARHGAP35 RGL1 DENND10 ARHGEF7 PLEKHG3 SGSM2 AGAP7P AGAP4 AGAP6	8.92e-05	507	126	12	GO:0030695
GeneOntologyMolecularFunction	cyclic nucleotide binding	PDE4A PDE4B PDE4D CNGA4	1.05e-04	39	126	4	GO:0030551
GeneOntologyMolecularFunction	GTPase activator activity	DOCK3 IQGAP2 TBC1D5 ARHGAP35 SGSM2 AGAP7P AGAP4 AGAP6	3.98e-04	279	126	8	GO:0005096
GeneOntologyMolecularFunction	GTPase binding	DOCK3 IQGAP2 SPTBN1 EXOC8 DENND10 ARHGEF7 PLEKHG3 SGSM2 SORL1	4.71e-04	360	126	9	GO:0051020
GeneOntologyMolecularFunction	small GTPase binding	DOCK3 IQGAP2 EXOC8 DENND10 ARHGEF7 PLEKHG3 SGSM2 SORL1	9.95e-04	321	126	8	GO:0031267
GeneOntologyBiologicalProcess	cAMP catabolic process	PDE4A PDE4B PDE4C PDE4D	1.53e-07	9	124	4	GO:0006198
GeneOntologyBiologicalProcess	cAMP metabolic process	CACNB4 PDE4A PDE4B PDE4C PDE4D	3.49e-07	25	124	5	GO:0046058
GeneOntologyBiologicalProcess	cyclic nucleotide catabolic process	PDE4A PDE4B PDE4C PDE4D	1.19e-06	14	124	4	GO:0009214
GeneOntologyBiologicalProcess	cyclic purine nucleotide metabolic process	CACNB4 PDE4A PDE4B PDE4C PDE4D	6.52e-06	44	124	5	GO:0052652
GeneOntologyBiologicalProcess	cyclic nucleotide metabolic process	CACNB4 PDE4A PDE4B PDE4C PDE4D	7.30e-06	45	124	5	GO:0009187
GeneOntologyBiologicalProcess	regulation of GTPase activity	PLXNA3 IQGAP2 TBC1D5 ARHGEF7 SGSM2 AGAP7P MLST8 AGAP4 AGAP6 PLXNA2	3.55e-05	335	124	10	GO:0043087
GeneOntologyBiologicalProcess	negative regulation of relaxation of cardiac muscle	PDE4B PDE4D	3.59e-05	2	124	2	GO:1901898
GeneOntologyCellularComponent	voltage-gated calcium channel complex	CACNB4 PDE4B CATSPERE PDE4D RYR1	7.95e-06	46	125	5	GO:0005891
GeneOntologyCellularComponent	cell leading edge	SPEF1 PDE4A IQGAP2 SPTBN1 SLC1A2 ITGB5 EXOC8 FAP IGF2BP1 PTPRK ARHGEF7 EXOC4	4.69e-05	500	125	12	GO:0031252
GeneOntologyCellularComponent	calcium channel complex	CACNB4 PDE4B CATSPERE PDE4D RYR1	7.66e-05	73	125	5	GO:0034704
GeneOntologyCellularComponent	Ndc80 complex	SPC25 NDC80	2.11e-04	4	125	2	GO:0031262
GeneOntologyCellularComponent	Schaffer collateral - CA1 synapse	PDE4A APBA2 SYNJ1 SYN2 EXOC4 EPHA7	3.42e-04	155	125	6	GO:0098685
GeneOntologyCellularComponent	perinuclear region of cytoplasm	PDE4A PDE4B PDE4C PDE4D CALR ABCC5 RYR1 EXOC8 EPG5 IGF2BP1 SYNJ1 UBR5 EIF2AK3 DYNC1I1 SORL1	4.65e-04	934	125	15	GO:0048471
Domain	PDEase	PDE4A PDE4B PDE4C PDE4D	6.03e-06	19	121	4	IPR023088
Domain	PDEase_I	PDE4A PDE4B PDE4C PDE4D	9.21e-06	21	121	4	PF00233
Domain	PDEASE_I	PDE4A PDE4B PDE4C PDE4D	9.21e-06	21	121	4	PS00126
Domain	PDEase_CS	PDE4A PDE4B PDE4C PDE4D	9.21e-06	21	121	4	IPR023174
Domain	-	PDE4A PDE4B PDE4C PDE4D	1.12e-05	22	121	4	1.10.1300.10
Domain	PDEase_catalytic_dom	PDE4A PDE4B PDE4C PDE4D	1.35e-05	23	121	4	IPR002073
Domain	HD/PDEase_dom	PDE4A PDE4B PDE4C PDE4D	1.61e-05	24	121	4	IPR003607
Domain	HDc	PDE4A PDE4B PDE4C PDE4D	1.61e-05	24	121	4	SM00471
Domain	CH-domain	SPEF1 IQGAP2 SPTBN1 ARHGEF7 NAV2	1.26e-04	75	121	5	IPR001715
Domain	PH_dom-like	LDLRAP1 SPTBN1 APBA2 EXOC8 ARHGEF7 PLEKHG3 AGAP7P AGAP4 AGAP6 ANKS1A	4.56e-04	426	121	10	IPR011993
Domain	PID	LDLRAP1 APBA2 ANKS1A	7.72e-04	28	121	3	PF00640
Domain	CH	IQGAP2 SPTBN1 ARHGEF7 NAV2	8.37e-04	65	121	4	SM00033
Domain	ArfGap	AGAP7P AGAP4 AGAP6	8.57e-04	29	121	3	SM00105
Domain	ARFGAP	AGAP7P AGAP4 AGAP6	8.57e-04	29	121	3	PS50115
Domain	ArfGap	AGAP7P AGAP4 AGAP6	8.57e-04	29	121	3	PF01412
Domain	ArfGAP	AGAP7P AGAP4 AGAP6	8.57e-04	29	121	3	IPR001164
Domain	-	LDLRAP1 SPTBN1 APBA2 EXOC8 ARHGEF7 PLEKHG3 AGAP4 AGAP6 ANKS1A	1.01e-03	391	121	9	2.30.29.30
Domain	CH	IQGAP2 SPTBN1 ARHGEF7 NAV2	1.11e-03	70	121	4	PF00307
Domain	Calx_beta	FRAS1 FREM3	1.14e-03	8	121	2	SM00237
Domain	PID	LDLRAP1 APBA2 ANKS1A	1.15e-03	32	121	3	PS01179
Domain	-	IQGAP2 SPTBN1 ARHGEF7 NAV2	1.17e-03	71	121	4	1.10.418.10
Domain	CH	IQGAP2 SPTBN1 ARHGEF7 NAV2	1.29e-03	73	121	4	PS50021
Domain	Calx_beta	FRAS1 FREM3	1.45e-03	9	121	2	IPR003644
Domain	Plexin_cytopl	PLXNA3 PLXNA2	1.45e-03	9	121	2	PF08337
Domain	Plexin_cytoplasmic_RasGAP_dom	PLXNA3 PLXNA2	1.45e-03	9	121	2	IPR013548
Domain	Plexin	PLXNA3 PLXNA2	1.45e-03	9	121	2	IPR031148
Domain	Calx-beta	FRAS1 FREM3	1.45e-03	9	121	2	PF03160
Pathway	WP_SILDENAFIL_TREATMENT	PDE4A PDE4B PDE4C PDE4D GUCY1B2	2.91e-07	23	90	5	M46455
Pathway	REACTOME_DARPP_32_EVENTS	PDE4A PDE4B PDE4C PDE4D	2.67e-06	16	90	4	MM14699
Pathway	REACTOME_DARPP_32_EVENTS	PDE4A PDE4B PDE4C PDE4D	1.50e-05	24	90	4	M751
Pathway	WP_PHOSPHODIESTERASES_IN_NEURONAL_FUNCTION	PDE4A PDE4B PDE4C PDE4D GUCY1B2	2.56e-05	55	90	5	M39763
Pathway	WP_PURINE_METABOLISM	PDE4A PDE4B PDE4C PDE4D IMPDH2 POLE GUCY1B2	1.10e-04	171	90	7	MM15909
Pathway	REACTOME_VXPX_CARGO_TARGETING_TO_CILIUM	EXOC8 CNGA4 EXOC4	2.65e-04	20	90	3	MM15208
Pathway	REACTOME_VXPX_CARGO_TARGETING_TO_CILIUM	EXOC8 CNGA4 EXOC4	3.08e-04	21	90	3	M27479
Pubmed	Molecular cloning and transient expression in COS7 cells of a novel human PDE4B cAMP-specific phosphodiesterase, HSPDE4B3.	PDE4A PDE4B PDE4C PDE4D	1.70e-10	4	127	4	9371714
Pubmed	Ibudilast (AV411), and its AV1013 analog, reduce HIV-1 replication and neuronal death induced by HIV-1 and morphine.	PDE4A PDE4B PDE4C PDE4D	1.70e-10	4	127	4	24732776
Pubmed	Assessment of PDE4 Inhibitor-Induced Hypothermia as a Correlate of Nausea in Mice.	PDE4A PDE4B PDE4C PDE4D	1.70e-10	4	127	4	34943270
Pubmed	PAN-selective inhibition of cAMP-phosphodiesterase 4 (PDE4) induces gastroparesis in mice.	PDE4A PDE4B PDE4C PDE4D	1.70e-10	4	127	4	32738081
Pubmed	A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs.	PDE4A PDE4B PDE4C PDE4D	1.70e-10	4	127	4	8413254
Pubmed	Role of phosphodiesterases in the shaping of sub-plasma-membrane cAMP oscillations and pulsatile insulin secretion.	PDE4A PDE4B PDE4C PDE4D	1.70e-10	4	127	4	22946044
Pubmed	Inhibition of cAMP-phosphodiesterase 4 (PDE4) potentiates the anesthetic effects of Isoflurane in mice.	PDE4A PDE4B PDE4C PDE4D	1.70e-10	4	127	4	33609559
Pubmed	The cAMP-phosphodiesterase 4 (PDE4) controls β-adrenoceptor- and CFTR-dependent saliva secretion in mice.	PDE4A PDE4B PDE4C PDE4D	8.45e-10	5	127	4	33944911
Pubmed	Interaction between LIS1 and PDE4, and its role in cytoplasmic dynein function.	PDE4A PDE4B PDE4D DYNC1I1	8.45e-10	5	127	4	21652625
Pubmed	A mouse homolog of dunce, a gene important for learning and memory in Drosophila, is preferentially expressed in olfactory receptor neurons.	PDE4A PDE4B PDE4C PDE4D	8.45e-10	5	127	4	8586960
Pubmed	Distinct roles of PDE4 and PDE10A in the regulation of cAMP/PKA signaling in the striatum.	PDE4A PDE4B PDE4C PDE4D	2.53e-09	6	127	4	18923023
Pubmed	Nonredundant function of phosphodiesterases 4D and 4B in neutrophil recruitment to the site of inflammation.	PDE4A PDE4B PDE4D	4.76e-08	3	127	3	15585880
Pubmed	Cyclic AMP phosphodiesterases are localized in regions of the mouse brain associated with reinforcement, movement, and affect.	PDE4A PDE4B PDE4D	4.76e-08	3	127	3	10213096
Pubmed	The upstream conserved regions (UCRs) mediate homo- and hetero-oligomerization of type 4 cyclic nucleotide phosphodiesterases (PDE4s).	PDE4A PDE4B PDE4D	4.76e-08	3	127	3	24555506
Pubmed	Critical role of PDE4D in beta2-adrenoceptor-dependent cAMP signaling in mouse embryonic fibroblasts.	PDE4A PDE4B PDE4D	4.76e-08	3	127	3	18508768
Pubmed	Differential expression and function of phosphodiesterase 4 (PDE4) subtypes in human primary CD4+ T cells: predominant role of PDE4D.	PDE4A PDE4B PDE4D	4.76e-08	3	127	3	17404263
Pubmed	Specific role of phosphodiesterase 4B in lipopolysaccharide-induced signaling in mouse macrophages.	PDE4A PDE4B PDE4D	4.76e-08	3	127	3	16034090
Pubmed	Chromosome localizations of genes for five cAMP-specific phosphodiesterases in man and mouse.	PDE4A PDE4B PDE4C PDE4D	1.18e-07	13	127	4	8009369
Pubmed	Phosphodiesterase 4B in the cardiac L-type Ca²⁺ channel complex regulates Ca²⁺ current and protects against ventricular arrhythmias in mice.	PDE4A PDE4B PDE4D	1.90e-07	4	127	3	21670503
Pubmed	Phosphodiesterase 4D is required for beta2 adrenoceptor subtype-specific signaling in cardiac myocytes.	PDE4A PDE4B PDE4D	1.90e-07	4	127	3	15644445
Pubmed	Inhibition of PDE3B augments PDE4 inhibitor-induced apoptosis in a subset of patients with chronic lymphocytic leukemia.	PDE4A PDE4B PDE4D	1.90e-07	4	127	3	11839681
Pubmed	Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome.	PDE4B IQGAP2 SPTBN1 SLC1A2 UBA1 SYNJ1 UBR5 ARHGEF7 ANKS1A	3.89e-07	251	127	9	27507650
Pubmed	Phosphodiesterase 4B negatively regulates endotoxin-activated interleukin-1 receptor antagonist responses in macrophages.	PDE4A PDE4B PDE4D	4.73e-07	5	127	3	28383060
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	CACNB4 PDE4A SFPQ PDE4B IMPDH2 IQGAP2 TBC1D5 SPTBN1 SLC1A2 ZNF462 UBA1 SYNJ1 UBR5 ARHGEF7 PIP4K2C ANKS1A	4.89e-07	963	127	16	28671696
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	PDE4D IQGAP2 SPTBN1 SYNJ1 UBR5 AGAP7P AGAP4 AGAP6 DYNC1I1	9.96e-07	281	127	9	28706196
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	LRRC8E SFPQ IMPDH2 CALR TBC1D5 SPTBN1 INTS8 ITGB5 EXOC8 B4GALT1 ZNF462 CCNT1 LMAN2L NDC80 PTPRK GOLIM4 EXOC4	1.93e-06	1203	127	17	29180619
Pubmed	Overview of PDEs and their regulation.	PDE4A PDE4B PDE4C PDE4D	2.02e-06	25	127	4	17307970
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	LRRC8E DOCK3 PLXNA3 FRAS1 PDE4A POLE ARHGAP35 ITGB5 C2CD2 RYR1 LMAN2L SYNJ1 SGSM2 NAV2 ULK4 SCARA3	2.91e-06	1105	127	16	35748872
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	KIF26B TBC1D5 SPTBN1 SIK1 DNAH7 FSIP2 SYNJ1 PLEKHG3 CLK3 OTUD7A NAV2 HELZ EXOC4 ANKS1A	3.42e-06	861	127	14	36931259
Pubmed	GGAPs, a new family of bifunctional GTP-binding and GTPase-activating proteins.	AGAP7P AGAP4 AGAP6	3.93e-06	9	127	3	12640130
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	DOCK3 LDLRAP1 SPTBN1 APBA2 ADNP2 ABCC5 INTS8 ZNF365 SYNJ1 PTPRK SBNO1 HECTD2 SGSM2 MLST8 DYNC1I1 EXOC4 BRWD1	4.63e-06	1285	127	17	35914814
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	FRAS1 IMPDH2 ATR POLE TBC1D5 DHX38 EXOC8 ARHGEF7 HELZ CMTR2 EXOC4 SORL1	5.00e-06	650	127	12	38777146
Pubmed	AGAP1/AP-3-dependent endocytic recycling of M5 muscarinic receptors promotes dopamine release.	AGAP7P AGAP4 AGAP6	5.60e-06	10	127	3	20664521
Pubmed	AGAP1, a novel binding partner of nitric oxide-sensitive guanylyl cyclase.	AGAP7P AGAP4 AGAP6	7.68e-06	11	127	3	15381706
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	PLXNA3 FRAS1 ATR CALR SPC25 ITGB5 B4GALT1 IGSF10 FAP UBA1 LMAN2L PTPRK GOLIM4 SCARA3 EIF2AK3 SORL1	8.29e-06	1201	127	16	35696571
Pubmed	SNX27-driven membrane localisation of OTULIN antagonises linear ubiquitination and NF-κB signalling activation.	TBC1D5 DHX38 HDAC8 HEATR5A SYNJ1 ARHGEF7 PIP4K2C EXOC4 ANKS1A	1.10e-05	378	127	9	34315543
Pubmed	A human MAP kinase interactome.	SFPQ KIF26B SPTBN1 ADNP2 SLC1A2 RGL1 ARHGEF7 NAV2 HELZ CPLANE1	1.26e-05	486	127	10	20936779
Pubmed	Phosphodiesterase 4B is essential for T(H)2-cell function and development of airway hyperresponsiveness in allergic asthma.	PDE4A PDE4B	1.32e-05	2	127	2	21047676
Pubmed	Effects of PDE4 gene polymorphisms on efficacy and adverse drug events of ritodrine therapy in preterm labor patients: a prospective observational study.	PDE4B PDE4D	1.32e-05	2	127	2	31324945
Pubmed	Overexpression of phosphodiesterase-4 subtypes involved in surgery-induced neuroinflammation and cognitive dysfunction in mice.	PDE4B PDE4D	1.32e-05	2	127	2	28235598
Pubmed	Attenuation of inhibitory prostaglandin E2 signaling in human lung fibroblasts is mediated by phosphodiesterase 4.	PDE4A PDE4C	1.32e-05	2	127	2	23043089
Pubmed	Crystal structures of the catalytic domain of phosphodiesterase 4B complexed with AMP, 8-Br-AMP, and rolipram.	PDE4B PDE4D	1.32e-05	2	127	2	15003452
Pubmed	PDE4D plays a critical role in the control of airway smooth muscle contraction.	PDE4B PDE4D	1.32e-05	2	127	2	14519662
Pubmed	Anxiogenic-like behavioral phenotype of mice deficient in phosphodiesterase 4B (PDE4B).	PDE4B PDE4D	1.32e-05	2	127	2	17700644
Pubmed	PGE(1) stimulation of HEK293 cells generates multiple contiguous domains with different [cAMP]: role of compartmentalized phosphodiesterases.	PDE4B PDE4D	1.32e-05	2	127	2	17088426
Pubmed	PDE4D and PDE4B function in distinct subcellular compartments in mouse embryonic fibroblasts.	PDE4B PDE4D	1.32e-05	2	127	2	21288894
Pubmed	Diazepam and rolipram differentially inhibit cyclic AMP-specific phosphodiesterases PDE4A1 and PDE4B3 in the mouse.	PDE4A PDE4B	1.32e-05	2	127	2	11267656
Pubmed	Stimulation of p70S6 kinase via a growth hormone-controlled phosphatidylinositol 3-kinase pathway leads to the activation of a PDE4A cyclic AMP-specific phosphodiesterase in 3T3-F442A preadipocytes.	PDE4A PDE4D	1.32e-05	2	127	2	9520403
Pubmed	Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitors.	PDE4B PDE4C	1.32e-05	2	127	2	17727341
Pubmed	Atropine augments cardiac contractility by inhibiting cAMP-specific phosphodiesterase type 4.	PDE4B PDE4D	1.32e-05	2	127	2	29123207
Pubmed	Nuclear transit of human zipcode-binding protein IMP1.	IGF2BP1 IGF2BP3	1.32e-05	2	127	2	12921532
Pubmed	The involvement of a conserved family of RNA binding proteins in embryonic development and carcinogenesis.	IGF2BP1 IGF2BP3	1.32e-05	2	127	2	11992722
Pubmed	RNA-binding IMPs promote cell adhesion and invadopodia formation.	IGF2BP1 IGF2BP3	1.32e-05	2	127	2	16541107
Pubmed	The Endosome Localized Arf-GAP AGAP1 Modulates Dendritic Spine Morphology Downstream of the Neurodevelopmental Disorder Factor Dysbindin.	AGAP7P AGAP4 AGAP6	1.32e-05	13	127	3	27713690
Pubmed	GTP-binding protein-like domain of AGAP1 is protein binding site that allosterically regulates ArfGAP protein catalytic activity.	AGAP7P AGAP4 AGAP6	1.68e-05	14	127	3	22453919
Pubmed	Inhibition of type 5 phosphodiesterase counteracts β2-adrenergic signalling in beating cardiomyocytes.	PDE4A PDE4B PDE4D	1.68e-05	14	127	3	25852085
Pubmed	HectD1 controls hematopoietic stem cell regeneration by coordinating ribosome assembly and protein synthesis.	SFPQ IMPDH2 IGF2BP1 IGF2BP3 EXOC4	1.74e-05	87	127	5	33711283
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	SFPQ PDE4D CALR DHX38 SPC25 B4GALT1 IGF2BP1 IGF2BP3 UBA1 NDC80 CSK UBR5 CDC16 MYBL1 EXOC4	2.18e-05	1155	127	15	20360068
Pubmed	Proteomic analysis of SARS-CoV-2 particles unveils a key role of G3BP proteins in viral assembly.	SFPQ IMPDH2 SPTBN1 IGF2BP1 IGF2BP3	2.41e-05	93	127	5	38245532
Pubmed	Unpackaging the genetics of mammalian fertility: strategies to identify the "reproductive genome".	MYBL1 BRWD1 TDRD12	2.57e-05	16	127	3	29878059
Pubmed	Alteration of Neuronal Excitability and Short-Term Synaptic Plasticity in the Prefrontal Cortex of a Mouse Model of Mental Illness.	PDE4A PDE4B PDE4D	2.57e-05	16	127	3	28283561
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	SFPQ IMPDH2 TBC1D5 DHX38 ARHGAP35 CCNT1 IGF2BP1 IGF2BP3 UBA1 SYNJ1 HELZ DHX29 ANKS1A	3.95e-05	934	127	13	33916271
Pubmed	IGF2BP1, IGF2BP2 and IGF2BP3 genotype, haplotype and genetic model studies in metabolic syndrome traits and diabetes.	IGF2BP1 IGF2BP3	3.96e-05	3	127	2	20627640
Pubmed	Expression of the RNA-binding protein VICKZ in normal hematopoietic tissues and neoplasms.	IGF2BP1 IGF2BP3	3.96e-05	3	127	2	17296566
Pubmed	Identification of plexin family molecules in mice.	PLXNA3 PLXNA2	3.96e-05	3	127	2	8806646
Pubmed	SH3BP1, an exocyst-associated RhoGAP, inactivates Rac1 at the front to drive cell motility.	EXOC8 EXOC4	3.96e-05	3	127	2	21658605
Pubmed	Leukocyte phosphodiesterase expression after lipopolysaccharide and during sepsis and its relationship with HLA-DR expression.	PDE4A PDE4B	3.96e-05	3	127	2	28356347
Pubmed	Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation.	IGF2BP1 IGF2BP3	3.96e-05	3	127	2	29476152
Pubmed	Expression of IGF-II mRNA-binding proteins (IMPs) in gonads and testicular cancer.	IGF2BP1 IGF2BP3	3.96e-05	3	127	2	16049158
Pubmed	A family of insulin-like growth factor II mRNA-binding proteins represses translation in late development.	IGF2BP1 IGF2BP3	3.96e-05	3	127	2	9891060
Pubmed	Differential expression of plexin-A subfamily members in the mouse nervous system.	PLXNA3 PLXNA2	3.96e-05	3	127	2	11241833
Pubmed	Interaction analysis of miR-1275/IGF2BP1/IGF2BP3 with the susceptibility to hepatocellular carcinoma.	IGF2BP1 IGF2BP3	3.96e-05	3	127	2	32134323
Pubmed	VICKZ proteins: a multi-talented family of regulatory RNA-binding proteins.	IGF2BP1 IGF2BP3	3.96e-05	3	127	2	15601260
Pubmed	Initiation of stress granule assembly by rapid clustering of IGF2BP proteins upon osmotic shock.	IGF2BP1 IGF2BP3	3.96e-05	3	127	2	32668274
Pubmed	Pivotal role of cyclic nucleoside phosphodiesterase 4 in Tat-mediated CD4+ T cell hyperactivation and HIV type 1 replication.	PDE4A PDE4B	3.96e-05	3	127	2	11114167
Pubmed	ZBP1 recognition of beta-actin zipcode induces RNA looping.	IGF2BP1 IGF2BP3	3.96e-05	3	127	2	20080952
Pubmed	Salt-Inducible Kinase 1 Terminates cAMP Signaling by an Evolutionarily Conserved Negative-Feedback Loop in β-Cells.	PDE4D SIK1	3.96e-05	3	127	2	25918234
Pubmed	Expression of Fraser syndrome genes in normal and polycystic murine kidneys.	FRAS1 FREM3	3.96e-05	3	127	2	21993971
Pubmed	Proteomic analysis of in vivo phosphorylated synaptic proteins.	CACNB4 SPTBN1 ARHGEF7 PLXNA2	4.32e-05	53	127	4	15572359
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	LDLRAP1 SFPQ ATR POLE SPTBN1 INTS8 NDC80 CSK CDC16 EXOC4	5.79e-05	582	127	10	20467437
Pubmed	Progesterone induced Warburg effect in HEK293 cells is associated with post-translational modifications and proteasomal degradation of progesterone receptor membrane component 1.	ATR UBA1 PTPRK UBR5	6.18e-05	58	127	4	31067491
Pubmed	A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.	PMPCB TBC1D5 ABCC5 INTS8 C2CD2 FEM1B EVA1B LMAN2L UBR5 ARHGEF7 EPHA7	6.94e-05	719	127	11	35337019
Pubmed	Oncogenic functions of protein kinase D2 and D3 in regulating multiple cancer-related pathways in breast cancer.	FREM3 UBR5 ARHGEF7 AGAP4 AGAP6	6.96e-05	116	127	5	30652415
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	DOCK3 CACNB4 SFPQ SPTBN1 APBA2 ARHGAP35 SLC1A2 UBA1 SYNJ1 ARHGEF7 CDC16 SYN2 HELZ DHX29	7.51e-05	1139	127	14	36417873
Pubmed	Segmental and restricted localization pattern of Fras1 in the developing meningeal basement membrane in mouse.	FRAS1 FREM3	7.90e-05	4	127	2	24101214
Pubmed	The RNA Binding Protein IMP2 Preserves Glioblastoma Stem Cells by Preventing let-7 Target Gene Silencing.	IGF2BP1 IGF2BP3	7.90e-05	4	127	2	27184842
Pubmed	Architecture of the human ndc80-hec1 complex, a critical constituent of the outer kinetochore.	SPC25 NDC80	7.90e-05	4	127	2	15961401
Pubmed	A genome-wide association study for age-related hearing impairment in the Saami.	IQGAP2 PTPRK	7.90e-05	4	127	2	20068591
Pubmed	Phosphoinositide 3-kinase γ protects against catecholamine-induced ventricular arrhythmia through protein kinase A-mediated regulation of distinct phosphodiesterases.	PDE4A PDE4B	7.90e-05	4	127	2	23008439
Pubmed	Myelin proteolipid protein forms a complex with integrins and may participate in integrin receptor signaling in oligodendrocytes.	CALR ITGB5	7.90e-05	4	127	2	12196561
Pubmed	H19 RNA binds four molecules of insulin-like growth factor II mRNA-binding protein.	IGF2BP1 IGF2BP3	7.90e-05	4	127	2	10875929
Pubmed	Chromosome assignment of four plexin A genes (Plxna1, Plxna2, Plxna3, Plxna4) in mouse, rat, Syrian hamster and Chinese hamster.	PLXNA3 PLXNA2	7.90e-05	4	127	2	11306810
Pubmed	Identification of two novel components of the human NDC80 kinetochore complex.	SPC25 NDC80	7.90e-05	4	127	2	14699129
Pubmed	PlexinA polymorphisms mediate the developmental trajectory of human corpus callosum microstructure.	PLXNA3 PLXNA2	7.90e-05	4	127	2	25518740
Pubmed	mTOR phosphorylates IMP2 to promote IGF2 mRNA translation by internal ribosomal entry.	IGF2BP1 IGF2BP3	7.90e-05	4	127	2	21576258
Pubmed	Semaphorin-plexin signalling genes associated with human breast tumourigenesis.	PLXNA3 PLXNA2	7.90e-05	4	127	2	21925246
Pubmed	Differential regulation of the insulin-like growth factor II mRNA-binding protein genes by architectural transcription factor HMGA2.	IGF2BP1 IGF2BP3	7.90e-05	4	127	2	15225648
Pubmed	Remodeling of ryanodine receptor complex causes "leaky" channels: a molecular mechanism for decreased exercise capacity.	PDE4D RYR1	7.90e-05	4	127	2	18268335
Pubmed	Differential localization profile of Fras1/Frem proteins in epithelial basement membranes of newborn and adult mice.	FRAS1 FREM3	7.90e-05	4	127	2	18563433
Pubmed	miR-1275: A single microRNA that targets the three IGF2-mRNA-binding proteins hindering tumor growth in hepatocellular carcinoma.	IGF2BP1 IGF2BP3	7.90e-05	4	127	2	26160756
GeneFamily	Phosphodiesterases	PDE4A PDE4B PDE4C PDE4D	3.90e-06	24	82	4	681
GeneFamily	Protein tyrosine phosphatases, receptor type	PTPRT PTPRK PTPRQ	1.13e-04	21	82	3	813
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	SPTBN1 ARHGEF7 PLEKHG3 AGAP7P AGAP4 AGAP6	3.47e-04	206	82	6	682
GeneFamily	ArfGAPs	AGAP7P AGAP4 AGAP6	4.45e-04	33	82	3	395
GeneFamily	Exocyst complex	EXOC8 EXOC4	7.17e-04	9	82	2	1055
GeneFamily	Plexins	PLXNA3 PLXNA2	7.17e-04	9	82	2	683
GeneFamily	Fibronectin type III domain containing	PTPRT PTPRK PTPRQ EPHA7 SORL1	8.04e-04	160	82	5	555
GeneFamily	Ankyrin repeat domain containing	ANKRD62 FEM1B AGAP7P AGAP4 AGAP6 ANKS1A	8.10e-04	242	82	6	403
GeneFamily	DEAH-box helicases	DHX38 DHX29	2.34e-03	16	82	2	500
GeneFamily	X-linked mental retardation\|Rho GTPase activating proteins\|BAR-PH domain containing	AGAP4 AGAP6	2.64e-03	17	82	2	1291
GeneFamily	Calcium voltage-gated channel subunits\|Membrane associated guanylate kinases	CACNB4 CARD14	6.15e-03	26	82	2	904
Coexpression	MANNO_MIDBRAIN_NEUROTYPES_HGABA	DOCK3 PLXNA3 CACNB4 PDE4C PDE4D CPEB3 APBA2 ABCC5 FHOD3 ARHGAP35 SLC1A2 PTPRT ZNF462 FSIP2 SYNJ1 PTPRK SYN2 BRWD1	5.90e-06	1106	126	18	M39071
ToppCell	COPD-Stromal-Myofibroblast\|Stromal / Disease state, Lineage and Cell class	FRAS1 PDE4D KIF26B FAT3 FAP MOXD1 SRGN NAV2 ULK4 PLXNA2	1.99e-10	192	126	10	62904f94dfce430456f05066522cbf9bd29f4d7e
ToppCell	metastatic_Brain-T/NK_cells-Exhausted_Tfh\|T/NK_cells / Location, Cell class and cell subclass	PDE4B POLE EXOC8 PTPRK OTUD7A AGAP4 AGAP6	7.66e-07	178	126	7	9a3581a0158dfa5a1cc942f8c532afb5e38b272a
ToppCell	TCGA-Endometrium-Primary_Tumor-Endometrial_Adenocarcinoma-Endometrioid-1\|TCGA-Endometrium / Sample_Type by Project: Shred V9	FRAS1 PDE4D KIF26B ADNP2 NAV2 DYNC1I1 EPHA7	1.32e-06	193	126	7	c2673d86f7d7b849788036032a93a6d136a70040
ToppCell	IPF-Multiplet-Multiplet\|IPF / Disease state, Lineage and Cell class	PDE4D SPTBN1 DNAH7 PTPRT PTPRK NAV2 VWA3B	1.41e-06	195	126	7	fce0c29574bb7aab181b9c00feb42681e285d1f2
ToppCell	IPF-Multiplet\|IPF / Disease state, Lineage and Cell class	PDE4D SPTBN1 DNAH7 PTPRT PTPRK NAV2 VWA3B	1.41e-06	195	126	7	eacc0449ae6f3ad8002268cd061467684c6fb9a7
ToppCell	(1)_T_cells-(1)_T_CD4_naive\|(1)_T_cells / Spleen cell shreds - cell class (v1) and cell subclass (v1)	LDLRAP1 IMPDH2 SPTBN1 APBA2 ARMH1 ATP8B2 SORL1	1.41e-06	195	126	7	d3fa551bc6f5ee5890af1040415e61ecd5d46201
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-3.5_mon-Proliferating-Cycling_Progenitors\|3.5_mon / Sample Type, Dataset, Time_group, and Cell type.	IQGAP2 SPC25 ITGB5 MOXD1 NDC80 SCARA3 MYBL1	1.46e-06	196	126	7	5905f0e3061a6b98b7a33d64c782c3dda2cd51ef
ToppCell	LPS_IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	FRAS1 HEATR5A FREM3 ZNF365 PLEKHG3 PTPRQ NAV2	1.56e-06	198	126	7	b598ab958e31f1e98bd06dc0097b58ac3a3f90a3
ToppCell	367C-Myeloid-Macrophage-SPP1+_Macrophage_2\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	SIK1 ZNF462 CCNT1 MAP3K15 SCARA3 EIF2AK3	3.48e-06	144	126	6	38ff324366ad5be626e3657c1e33277fc36ddd4c
ToppCell	5'-Adult-Appendix-Hematopoietic-B_cells-Cycling_B_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	IGF2BP1 IGF2BP3 UBR5 PTPRQ MYBL1 SORL1	5.51e-06	156	126	6	203ef22eb76bd2b829b027c30af0557080f4006c
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FRAS1 CACNB4 PDE4D KIF26B FHOD3 ZNF365	8.72e-06	169	126	6	0332f539a2f7d6dcd081a5d2f567290721f5a329
ToppCell	PND28-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_G2M\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PLXNA3 SPC25 NDC80 NAV2 VWA3B MYBL1	1.03e-05	174	126	6	72df66319f6efbd88ecf439013d97409fbf3cb52
ToppCell	PND28-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PLXNA3 SPC25 NDC80 NAV2 VWA3B MYBL1	1.03e-05	174	126	6	c6087fd0e036ec7f40f0f8f17d1f6ce13ddb5235
ToppCell	RSV-Healthy-0\|RSV / Virus stimulation, Condition and Cluster	PDE4A CALR B4GALT1 CSK CPLANE1 MYBL1	1.25e-05	180	126	6	974044056e2f7e909cb11c6f6ca89e58bf95f7e5
ToppCell	RSV-Healthy-0\|Healthy / Virus stimulation, Condition and Cluster	PDE4A CALR B4GALT1 CSK CPLANE1 MYBL1	1.25e-05	180	126	6	703a1d0f9536af94d56757eb01221878d7b7fe61
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FRAS1 CACNB4 PDE4D KIF26B FHOD3 ZNF365	1.25e-05	180	126	6	788d5fbf688365b5d92d3aa19b9f8e9448f8be5a
ToppCell	Adult-Immune-interstitial_macrophage_(C1Q_positive)-D175\|Adult / Lineage, Cell type, age group and donor	PDE4B RYR1 EXOC8 RGL1 SRGN CD33	1.46e-05	185	126	6	ab5704b96f1d368911308797d10c7c52766ab134
ToppCell	wk_15-18-Epithelial-Distal_epithelial_progenitor-epi-tip_intermediate\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	FRAS1 CACNB4 ZNF607 POLE SGSM2 PLXNA2	1.46e-05	185	126	6	636505a3d96f75d951ab42bcf8af6ae07abc732d
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PDE4D KIF26B FHOD3 ZNF462 PTPRK EPHA7	1.50e-05	186	126	6	b87acc80b7baa41681e4ed11d5537b9fbf5832f5
ToppCell	renal_cortex_nuclei-Adult_normal_reference\|renal_cortex_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group	FRAS1 PDE4D AOX1 ARHGEF7 SRGN PLXNA2	1.65e-05	189	126	6	a48df46274d51e84ffb40264646de7346104efb9
ToppCell	Children_(3_yrs)-Immune-interstitial_macrophage_(C1Q_positive)\|Children_(3_yrs) / Lineage, Cell type, age group and donor	PDE4B IQGAP2 ABCC5 RYR1 RGL1 ANKS1A	1.70e-05	190	126	6	f573fef3762a30c38cf8fa7f45df0ffbb49dc873
ToppCell	(5)_Fibroblasts-(5)_Fibroblast-C_(Myofibroblast)\|(5)_Fibroblasts / Lung cell shreds - cell class (v4) and cell subclass (v4)	FRAS1 FAT3 SPTBN1 MOXD1 SRGN SORL1	1.70e-05	190	126	6	71e112dfb8c3190fe0286b45a046ea789eb6a8db
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PDE4D KIF26B FHOD3 ZNF462 PTPRK EPHA7	1.75e-05	191	126	6	1cb02007adb344f17ef73d58890f91298c7cf5a1
ToppCell	renal_cortex_nuclei\|World / Celltypes from Cells and Nuclei per compartment and clinical group	FRAS1 PDE4D TBC1D5 FHOD3 PTPRK EXOC4	1.80e-05	192	126	6	e8cc4d08fcfceeab75a02558817e4ccd7dbafe3a
ToppCell	Control-CD8+_T_naive\|Control / Disease condition and Cell class	LDLRAP1 IMPDH2 SPTBN1 APBA2 ARMH1 PTPRK	1.85e-05	193	126	6	627d345baf1940218c61907305705298e473dbab
ToppCell	Adult-Immune-interstitial_macrophage_(C1Q_positive)\|Adult / Lineage, Cell type, age group and donor	IQGAP2 ABCC5 RYR1 RGL1 SRGN CD33	1.85e-05	193	126	6	31c0978ba78c9516d498aec0798902e57555e557
ToppCell	Control-NK_CD56bright\|Control / Disease condition and Cell class	KIF26B SPTBN1 B4GALT1 EVA1B SRGN GOLIM4	1.85e-05	193	126	6	8b1e7a226a6057e1097c1525984127b54e823876
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	PDE4D FAT3 SPTBN1 FAP HECTD2 DYNC1I1	1.91e-05	194	126	6	b1bb0f846d2865efdd9bc8842b16b9d069785882
ToppCell	10x5'-lymph-node_spleen-Lymphocytic_NK-NK_CD56bright_CD16-\|lymph-node_spleen / Manually curated celltypes from each tissue	PDE4A IQGAP2 SRGN GOLIM4 HELZ MYBL1	1.91e-05	194	126	6	8a596f25f6bfa5baaa2f52d80ad92f2925713398
ToppCell	10x5'-bone_marrow-Lymphocytic_NK-NK_CD56bright_CD16-\|bone_marrow / Manually curated celltypes from each tissue	PDE4A PDE4B APBA2 SRGN GOLIM4 MYBL1	1.91e-05	194	126	6	5c58a2d1dd3c8ff77ce44d473239685e6b020909
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	PDE4D FAT3 SPTBN1 FAP HECTD2 DYNC1I1	1.96e-05	195	126	6	0e55fa5b3cbeb7baee3d4ac272a3bf80381ec937
ToppCell	367C-Fibroblasts-Fibroblast-C_(Myofibroblast)-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	FRAS1 FAT3 SPTBN1 MOXD1 SRGN SORL1	2.02e-05	196	126	6	6730743cf088c419ccc2d28765769fc09d3ba6a7
ToppCell	367C-Fibroblasts-Fibroblast-C_(Myofibroblast)\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	FRAS1 FAT3 SPTBN1 MOXD1 SRGN SORL1	2.02e-05	196	126	6	21dab89f3699037138a9c7a0e4dc98739a9fad9c
ToppCell	Bronchial-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_airway_ASM\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DOCK3 FAT3 FHOD3 MOXD1 SCARA3 EPHA7	2.02e-05	196	126	6	9830fb3da7a60f65ad463e9054bb77c06b025e4d
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature3_(17)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	PDE4D FAT3 SPTBN1 IGSF10 HECTD2 DYNC1I1	2.08e-05	197	126	6	31a1852911bda38543916585fda34255fd62a134
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature1_(0)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	FRAS1 FAT3 SPTBN1 IGSF10 HECTD2 DYNC1I1	2.08e-05	197	126	6	0034bae02ee7fcfea520d453ca3c842ab6963b12
ToppCell	COVID-19-lung-Fibroblast\|lung / Disease (COVID-19 only), tissue and cell type	FRAS1 KIF26B AOX1 FAP MOXD1 NAV2	2.14e-05	198	126	6	df3de77216f5c5d6141ec44d01c56b942f611838
ToppCell	Fetal_29-31_weeks\|World / Lineage, Cell type, age group and donor	FRAS1 KIF26B FAT3 IGF2BP1 MOXD1 IGF2BP3	2.20e-05	199	126	6	5b9d355795dd03a22f0961dfd143425c367a4654
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	DOCK3 VSTM2B SLC1A2 PTPRT ZNF462 AKR1E2	2.20e-05	199	126	6	333056c2abe9724efeab542c0365fcfe4eff8f18
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW10-Neuronal-Intermediate\|GW10 / Sample Type, Dataset, Time_group, and Cell type.	LRRC8E DNAH7 PTPRQ MAP3K15 SCARA3 CARD14	2.20e-05	199	126	6	cf592d93612023a13de21e0fb8c6b13714f9af71
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	DOCK3 VSTM2B SLC1A2 PTPRT ZNF462 AKR1E2	2.20e-05	199	126	6	19a97e27a4758e794ce7246d295e112b47931a48
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	DOCK3 VSTM2B SLC1A2 PTPRT ZNF462 AKR1E2	2.20e-05	199	126	6	e60ecbb8fa7bcd3e2ce7d78f6efb2cfd1fd77698
ToppCell	wk_15-18-Mesenchymal-Fibroblast-Alveolar_fibro\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	FAT3 SPTBN1 IGSF10 MOXD1 HECTD2 DYNC1I1	2.20e-05	199	126	6	6bce8e65859a35cfea1c210f9c9765952d492ed2
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW08-Neuronal-Intermediate\|GW08 / Sample Type, Dataset, Time_group, and Cell type.	LDLRAP1 EXOC8 VWA3B ZBTB3 CMTR2 EIF2AK3	2.26e-05	200	126	6	401d50fa394fa863fa7836344110ae5c7af3250a
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Oligoastrocytoma-9\|TCGA-Brain / Sample_Type by Project: Shred V9	HEATR5A FREM3 DNAH7 RYR1 CARD14	3.98e-05	134	126	5	2647453f44b0e0a8f27ef9bba750e99eb40efc8b
ToppCell	367C-Myeloid-Macrophage-SPP1+_Macrophage_2\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	SIK1 CCNT1 MAP3K15 SCARA3 EIF2AK3	5.60e-05	144	126	5	3ba7f8bd6d1c551048403c94693d63e60f7cbbb7
ToppCell	IIH-CD8-proli_CD4\|IIH / Condition, Cell_class and T cell subcluster	ZNF607 INTS8 PM20D2 DHX29 TDRD12	5.98e-05	146	126	5	7fa6e35def3f7cffbee1e1c2f10b523bab678e14
ToppCell	343B-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0\|343B / Donor, Lineage, Cell class and subclass (all cells)	IQGAP2 PLEKHG3 AGAP4 MYBL1 SORL1	7.02e-05	151	126	5	78475027bba9e3026e42493fec8ea630972353bb
ToppCell	facs-Brain_Non-Myeloid-Hippocampus_-18m-Macroglial-astrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AOX1 ARMH1 SLC1A2 RYR1 SCARA3	7.70e-05	154	126	5	5ed64bbf603290e6dc34f81d145982690b89dd0d
ToppCell	10x5'-Liver-Lymphocytic_T_CD4-Tfh\|Liver / Manually curated celltypes from each tissue	CACNB4 POLE FHOD3 EPG5 AGAP4	8.19e-05	156	126	5	85bc34ff507f9a66c6e3ba7a3ffd5416d0073ccf
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_ILC\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	PDE4C IQGAP2 APBA2 SRGN SORL1	8.44e-05	157	126	5	170197b76620df31495f1247f365da382b2d8045
ToppCell	Children_(3_yrs)-Epithelial-basal_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	FRAS1 CACNB4 FHOD3 PLXNA2 EPHA7	8.44e-05	157	126	5	6ee2692f705bdd93ba523dffaf2f0cd921b47e28
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_ILC-NK_cell\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	PDE4C IQGAP2 APBA2 SRGN SORL1	8.44e-05	157	126	5	c21520301cc0d5d4b1cc4b8ec735f9adb698e768
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_ILC-NK_cell-NK_c01-FCGR3A\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	PDE4C IQGAP2 APBA2 SRGN SORL1	8.69e-05	158	126	5	7274f020c0ecf216da4b6689c62bc5f49c29b6f3
ToppCell	facs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DOCK3 FRAS1 POLE FAT3 PTPRQ	9.78e-05	162	126	5	bf886e22ff2a20353499004b53f25fb9e6574896
ToppCell	368C-Fibroblasts-Fibroblast-E\|368C / Donor, Lineage, Cell class and subclass (all cells)	CACNB4 SPC25 ITGB5 ATP8B2 GOLIM4	9.78e-05	162	126	5	e17632778a57c71d6005d3abca3a0443a92040e7
ToppCell	368C-Fibroblasts-Fibroblast-E-\|368C / Donor, Lineage, Cell class and subclass (all cells)	CACNB4 SPC25 ITGB5 ATP8B2 GOLIM4	9.78e-05	162	126	5	ac4a80fd72c9311ea2b3e574c6284bbce4f2756c
ToppCell	Ciliated_cells-B-Donor_03\|World / lung cells shred on cell class, cell subclass, sample id	MGAT4D DYNLT2B SPEF1 DNAH7 PTPRT	1.04e-04	164	126	5	fd30c55d0d75ef8b9396435d836187168095152b
ToppCell	Ciliated_cells-A-Donor_05\|World / lung cells shred on cell class, cell subclass, sample id	SPEF1 FHOD3 DNAH7 PTPRT VWA3B	1.07e-04	165	126	5	0ebdbbdb151fb797335013d5838af1c7bbc45b06
ToppCell	wk_08-11-Mesenchymal-Fibroblast-Alveolar_fibro\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	FAT3 RGL1 MOXD1 ZACN HECTD2	1.10e-04	166	126	5	65dafed953b01a9830b54309af75c7a561e88336
ToppCell	droplet-Limb_Muscle-nan-3m-Myeloid-chondrocyte-like\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FHOD3 ZNF462 HECTD2 CD33 EPHA7	1.10e-04	166	126	5	35db3022c33d6f8bb6587d9eec89a7cccb70271a
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Degenerative_Proximal_Tubule_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ZNF365 PTPRT RYR1 IGF2BP3 TDRD12	1.13e-04	167	126	5	3edb0570e583bb527165bcd8a4c25a042054043b
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c04-ANXA2\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	PDE4D IQGAP2 EPG5 ZNF462 MYBL1	1.19e-04	169	126	5	01a24a8817628125bd004b2be68ffa62c7111f6e
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_3\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	KIF26B FSIP2 PLEKHG3 SCARA3 EPHA7	1.23e-04	170	126	5	5d5f208682be21ed58320f5fc083a7898f8712da
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Granulocytic\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PDE4A IQGAP2 RYR1 SRGN CD33	1.30e-04	172	126	5	3a37569a5902f3c65ff8d3912421309a8c82ee9b
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Granulocytic-Mast_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PDE4A IQGAP2 RYR1 SRGN CD33	1.30e-04	172	126	5	cc9d9dae290f11f8c348c78228af4e49469dc93b
ToppCell	PND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_G2M\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SPC25 C2CD2 MOXD1 CCM2L NDC80	1.37e-04	174	126	5	6c36d607c48267a75ab4da6fb2fe3f931d1b3b52
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FAT3 PTPRT ZNF462 SCARA3 EPHA7	1.44e-04	176	126	5	327a3e81b724252e36d786de92a3ffd721ea6d7b
ToppCell	PND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_G2M\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	POLE SPC25 ITGB5 NDC80 HECTD2	1.48e-04	177	126	5	3e149bff1f1b393a7abe98984e37981c8296f95d
ToppCell	severe-Myeloid-Neutrophils_1\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	CACNB4 PDE4B GUCY1B2 SRGN SORL1	1.48e-04	177	126	5	d1ad35ee3d2a84b1d01126d0a38464ab858c00d0
ToppCell	Children_(3_yrs)-Epithelial-basal_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	FRAS1 FHOD3 SCARA3 PLXNA2 EPHA7	1.52e-04	178	126	5	fba2e38c05cbf031e0c6d47b1602575fea734a57
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_3\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FAT3 ANKRD62 FREM3 MOXD1 PTPRK	1.52e-04	178	126	5	ccea3c8908d72f5fecd151a133048c8e9758304c
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c08-IL2RB\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	POLE APBA2 MAP3K15 MYBL1 SORL1	1.56e-04	179	126	5	db76edd368eeca05a2a5d407c3eb2f535ade0ce3
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FRAS1 CACNB4 PDE4D FHOD3 MAP3K15	1.56e-04	179	126	5	666072c0e8448dbaec1683d18368ec2502453f90
ToppCell	facs-Lung-EPCAM-3m-Myeloid-Dendritic_Cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATR SPC25 SLC1A2 SYN2 EIF2AK3	1.60e-04	180	126	5	710526abedc8e0f9ba19ad69220df4c9468ada8f
ToppCell	Ciliated_cells-A-Donor_07\|World / lung cells shred on cell class, cell subclass, sample id	DYNLT2B SPEF1 DNAH7 PTPRT VWA3B	1.60e-04	180	126	5	d9be152773fe9f2160edad9246fa03c03afeafd6
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c06-NR4A2\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	LDLRAP1 APBA2 SRGN MYBL1 SORL1	1.60e-04	180	126	5	f3d35b2ea78afef37a84232adf5e6e26712b618d
ToppCell	LPS-IL1RA-Endothelial-Endothelial-Alv_Cap\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FRAS1 PDE4B SPTBN1 EVA1B SRGN	1.60e-04	180	126	5	544fb373a3346186ec60afe2cfcf141bb04a1eed
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	IQGAP2 ZNF365 SRGN MYBL1 SORL1	1.60e-04	180	126	5	d9dae9db8e17f6990032ee6cfa8393fae4768ca5
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FRAS1 PDE4D IQGAP2 FHOD3 MAP3K15	1.64e-04	181	126	5	aa233b652921848af2257cc3687a7a09c3acfb67
ToppCell	wk_08-11-Epithelial-Proximal_epithelial-Ciliated\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	SPEF1 CATSPERE PTPRT VWA3B CNGA4	1.64e-04	181	126	5	8eed9d46d924b16f6dd1a025ff612244b02b4391
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	FRAS1 FAT3 IGSF10 FAP MOXD1	1.64e-04	181	126	5	9ede19228ba5c0668a9c06c915510b95585216ef
ToppCell	RA-17._Lymphocyte\|RA / Chamber and Cluster_Paper	IQGAP2 APBA2 SRGN MYBL1 SORL1	1.69e-04	182	126	5	257a7847917b6ea1d60608183d90300bfd028758
ToppCell	E18.5-samps-Endothelial-Mature_fetal_endothelial-endothelial_cells_A\|E18.5-samps / Age Group, Lineage, Cell class and subclass	PDE4B POLE SPC25 CCM2L NDC80	1.69e-04	182	126	5	ea4f6c8f600ffe9f8e0609637b3371a5ac48ca03
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Myeloid-Dendritic\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	ITGB5 RYR1 RGL1 CD33 GOLIM4	1.69e-04	182	126	5	9a68d3bd1cc9139de9e9e711c249d47ade826bb1
ToppCell	368C-Epithelial_cells-Epithelial-F_(Ciliated)-\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	DYNLT2B SPEF1 CATSPERE DNAH7 VWA3B	1.69e-04	182	126	5	975f6275777fc578eba528e50f69891c66ec44ad
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Myeloid-Dendritic-conventional_dendritic_cell\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	ITGB5 RYR1 RGL1 CD33 GOLIM4	1.69e-04	182	126	5	d57d18732aa6fb7b2d430601568f9ba525ac6e3c
ToppCell	368C-Epithelial_cells-Epithelial-F_(Ciliated)\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	DYNLT2B SPEF1 CATSPERE DNAH7 VWA3B	1.69e-04	182	126	5	f8c28fa76751062c4cfba0db8af1b377f947f739
ToppCell	10x3'2.3-week_17-19-Mesenchymal_osteo-stroma-early_osteoblast\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	LRRC8E FAT3 ITGB5 SCARA3 DYNC1I1	1.73e-04	183	126	5	27a57cd8ea924420e182f3d72f5b29b00dea8fa0
ToppCell	TCGA-Liver-Primary_Tumor-Hepatocellular_Carcinoma-Hepatocellular_Carcinoma-5\|TCGA-Liver / Sample_Type by Project: Shred V9	SFPQ SPC25 INTS8 IGF2BP3 NDC80	1.73e-04	183	126	5	f604a8b62c7088fad8365dbf8d910fc980bd3ba8
ToppCell	Striatum-Macroglia-POLYDENDROCYTE-P5\|Striatum / BrainAtlas - Mouse McCarroll V32	SFPQ POLE SPC25 GUCY1B2 NDC80	1.73e-04	183	126	5	f20b0d71f857ac35868fd80531050ad8b6091716
ToppCell	RA-17._Lymphocyte\|World / Chamber and Cluster_Paper	IQGAP2 APBA2 SRGN MYBL1 SORL1	1.73e-04	183	126	5	6397f684a50346fc42cccb5afbe10350f4b2d9b0
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FRAS1 CACNB4 FHOD3 MAP3K15 SORL1	1.73e-04	183	126	5	2e831a4d99c6f983793df71c0994124c943c6da9
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRAS1 KIF26B FAT3 PTPRQ EPHA7	1.77e-04	184	126	5	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRAS1 KIF26B FAT3 PTPRQ EPHA7	1.77e-04	184	126	5	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRAS1 KIF26B FAT3 PTPRQ EPHA7	1.77e-04	184	126	5	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	(3)_Mast_cells\|World / Oesophagus cell shreds on cell class (v1) and cell subclass (v1)	PDE4A IQGAP2 ARMH1 SRGN CD33	1.77e-04	184	126	5	dbfad62b925d835632b39a88ab95bd9af9cb7bee
ToppCell	(3)_Mast_cell\|World / Oesophagus cell shreds on cell class (v1) and cell subclass (v1)	PDE4A IQGAP2 ARMH1 SRGN CD33	1.77e-04	184	126	5	482907d3669597e25c8ff3e9a802a31415a0d654
ToppCell	Children_(3_yrs)-Immune-interstitial_macrophage_(C1Q_positive)-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	IQGAP2 ABCC5 RYR1 RGL1 NAV2	1.82e-04	185	126	5	8207f9eff113eed429e961748c6b17d672a13b33
ToppCell	PCW_07-8.5-Neuronal-Neuronal_SCP\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	FRAS1 PDE4B FHOD3 VSTM2B SYN2	1.82e-04	185	126	5	56c7a0dbf141728ac76b8c90af197719942ca67c
Drug	Piclamilast	PDE4A PDE4B PDE4C PDE4D	8.66e-10	4	125	4	DB01791
Drug	Ibudilast	PDE4A PDE4B PDE4C PDE4D	4.31e-09	5	125	4	DB05266
Drug	1,7-naphthyridine	PDE4A PDE4B PDE4C PDE4D	4.31e-09	5	125	4	CID000009209
Drug	Ketotifen	PDE4A PDE4B PDE4C PDE4D	2.99e-08	7	125	4	DB00920
Drug	Iloprost	PDE4A PDE4B PDE4C PDE4D	2.99e-08	7	125	4	DB01088
Drug	Dyphylline	PDE4A PDE4B PDE4C PDE4D	5.96e-08	8	125	4	DB00651
Drug	trequinsin	PDE4A PDE4B PDE4C PDE4D	1.07e-07	9	125	4	ctd:C035964
Drug	L-826,141	PDE4A PDE4B PDE4C PDE4D	1.07e-07	9	125	4	ctd:C459562
Drug	4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid	PDE4A PDE4B PDE4D	1.62e-07	3	125	3	DB08299
Drug	NVP ABE171	PDE4A PDE4B PDE4C PDE4D	1.77e-07	10	125	4	ctd:C451724
Drug	zaprinast	PDE4A PDE4B PDE4C PDE4D CALR ABCC5 RYR1 CARD14	1.13e-06	141	125	8	CID000005722
Drug	Roflumilast	PDE4A PDE4B PDE4C PDE4D	1.50e-06	16	125	4	ctd:C424423
Drug	D-22888	PDE4A PDE4B PDE4D	1.60e-06	5	125	3	CID000197714
Drug	Cilomilast	PDE4A PDE4B PDE4C PDE4D	2.50e-06	18	125	4	ctd:C433247
Drug	AA-2379	PDE4A PDE4B PDE4C PDE4D	4.82e-06	21	125	4	CID000128390
Drug	HWA 153	PDE4A PDE4B PDE4C PDE4D	5.87e-06	22	125	4	CID000162797
Drug	griseolic acid	PDE4A PDE4B PDE4C PDE4D	7.07e-06	23	125	4	CID000127607
Drug	atherosperminine	PDE4A PDE4B PDE4C PDE4D	7.07e-06	23	125	4	CID000096918
Drug	KF18280	PDE4A PDE4B PDE4D	8.87e-06	8	125	3	CID003071941
Drug	desethyl KBT-3022	PDE4A PDE4B PDE4C PDE4D	1.18e-05	26	125	4	CID000127736
Drug	T-440	PDE4A PDE4B PDE4C PDE4D	1.18e-05	26	125	4	CID000177965
Drug	Ro 15-2041	PDE4A PDE4B PDE4C PDE4D	1.18e-05	26	125	4	CID000132434
Drug	Clenbuterol hydrochloride [21898-19-1]; Up 200; 12.8uM; MCF7; HT_HG-U133A	PDE4A CPEB3 APBA2 RYR1 EVA1B SYN2 PLXNA2 CARD14	1.25e-05	195	125	8	5631_UP
Drug	imidazole-4-carboxamide	PDE4A PDE4B PDE4C PDE4D	2.76e-05	32	125	4	CID000152917
Drug	V11294 Analogue 5f	PDE4B PDE4D	2.99e-05	2	125	2	CID011214587
Drug	V11294 Analogue 5t	PDE4B PDE4D	2.99e-05	2	125	2	CID011226695
Drug	V11294 Analogue 5e	PDE4B PDE4D	2.99e-05	2	125	2	CID011443441
Drug	V11294 Analogue 5n	PDE4B PDE4D	2.99e-05	2	125	2	CID011238279
Drug	V11294 Analogue 5p	PDE4B PDE4D	2.99e-05	2	125	2	CID011478659
Drug	V11294 Analogue 5o	PDE4B PDE4D	2.99e-05	2	125	2	CID011249748
Drug	V11294 Analogue 5c	PDE4B PDE4D	2.99e-05	2	125	2	CID011179896
Drug	V11294 Analogue 5b	PDE4B PDE4D	2.99e-05	2	125	2	CID011443760
Drug	Cis-4-Cyano-4-[3-(Cyclopentyloxy)-4-Methoxyphenyl]Cyclohexanecarboxylic Acid	PDE4B PDE4D	2.99e-05	2	125	2	DB03849
Drug	T-2585.HCl	PDE4B PDE4D	2.99e-05	2	125	2	CID006918355
Drug	V11294 Analogue 5m	PDE4B PDE4D	2.99e-05	2	125	2	CID011477773
Drug	V11294 Analogue 8a	PDE4B PDE4D	2.99e-05	2	125	2	CID011442865
Drug	V11294 Analogue 5q	PDE4B PDE4D	2.99e-05	2	125	2	CID011318772
Drug	V11294 Analogue 5h	PDE4B PDE4D	2.99e-05	2	125	2	CID011306698
Drug	3,5-Dimethyl-1-(3-Nitrophenyl)-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester	PDE4B PDE4D	2.99e-05	2	125	2	DB01959
Drug	4-[3-(Cyclopentyloxy)-4-Methoxyphenyl]-2-Pyrrolidinone	PDE4B PDE4D	2.99e-05	2	125	2	DB01954
Drug	M 98	PDE4B PDE4D	2.99e-05	2	125	2	CID006420180
Drug	V11294 Analogue 5i	PDE4B PDE4D	2.99e-05	2	125	2	CID011376249
Drug	V11294 Analogue 5d	PDE4B PDE4D	2.99e-05	2	125	2	CID011283750
Drug	3-cyclopentyloxy-4-methoxybenzoic acid	PDE4B PDE4D	2.99e-05	2	125	2	CID002779323
Drug	V11294 Analogue 5v	PDE4B PDE4D	2.99e-05	2	125	2	CID011375325
Drug	3-cyclopentyloxy-4-methoxybenzaldehyde	PDE4B PDE4D	2.99e-05	2	125	2	CID002735893
Drug	Np-V	PDE4B PDE4D	2.99e-05	2	125	2	CID009999276
Drug	(S)-Rolipram	PDE4B PDE4D	2.99e-05	2	125	2	DB03606
Drug	1-((5-(1-aminoethyl)-2-(8-methoxy-2-(triflurormethyl)-5-quinolinyl)-4-oxazolyl) carbonyl)-4-((cyclopropylcarbonyl)amino)proline ethyl ester	PDE4B PDE4D	2.99e-05	2	125	2	ctd:C554440
Drug	V11294 Analogue 5r	PDE4B PDE4D	2.99e-05	2	125	2	CID011168555
Drug	V11294 Analogue 5j	PDE4B PDE4D	2.99e-05	2	125	2	CID011433797
Drug	V11294 Analogue 5a	PDE4B PDE4D	2.99e-05	2	125	2	CID011386897
Drug	V11294 Analogue 5k	PDE4B PDE4D	2.99e-05	2	125	2	CID011456440
Drug	(R)-Rolipram	PDE4B PDE4D	2.99e-05	2	125	2	DB04149
Drug	(4R)-4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one	PDE4A PDE4D	2.99e-05	2	125	2	DB06842
Drug	dyphylline	PDE4A PDE4B PDE4C PDE4D	3.13e-05	33	125	4	CID000003182
Drug	felodipine	CACNB4 PDE4A PDE4B PDE4C PDE4D RYR1 NDC80	4.19e-05	169	125	7	CID000003333
Drug	PDEs	PDE4A PDE4B PDE4C PDE4D ABCC5 CARD14	4.40e-05	116	125	6	CID003036959
Drug	AH 21-132	PDE4A PDE4B PDE4C PDE4D	4.97e-05	37	125	4	CID003035793
Drug	papaverine	CACNB4 PDE4A PDE4B PDE4C PDE4D RYR1 CARD14	5.42e-05	176	125	7	CID000004680
Drug	Camptothecine (S,+) [7689-03-4]; Down 200; 11.4uM; PC3; HT_HG-U133A	ADNP2 IGF2BP3 NDC80 ARHGEF7 NAV2 EIF2AK3 ANKS1A	6.25e-05	180	125	7	4541_DN
Drug	NSC18930	PDE4A PDE4B PDE4C PDE4D IMPDH2	6.63e-05	77	125	5	CID000001189
Drug	DTIC	PDE4A PDE4B PDE4C PDE4D HDAC8	8.45e-05	81	125	5	CID005281007
Drug	CDP840	PDE4A PDE4B PDE4D	8.59e-05	16	125	3	CID000127928
Drug	Isotretinoin [4759-48-2]; Up 200; 13.4uM; MCF7; HT_HG-U133A	DOCK3 CACNB4 PDE4A PDE4C RGL1 MOXD1 EVA1B	8.78e-05	190	125	7	6017_UP
Drug	BW A78U	PDE4B PDE4D	8.94e-05	3	125	2	CID000127779
Drug	Enprofylline	PDE4A PDE4B	8.94e-05	3	125	2	DB00824
Drug	Org 4428	PDE4B PDE4D	8.94e-05	3	125	2	CID000166560
Drug	1-Pyrrolidinebutanenitrile	PDE4B PDE4D	8.94e-05	3	125	2	CID000118838
Drug	AC1L73CW	PDE4A PDE4B PDE4C PDE4D RGL1	1.00e-04	84	125	5	CID000328776
Drug	Org 9935	PDE4B PDE4D CALR	1.04e-04	17	125	3	CID000131100
Drug	Caffeine	PDE4B RYR1	1.78e-04	4	125	2	DB00201
Drug	milrinone	PDE4A PDE4B PDE4C PDE4D CALR CARD14	1.82e-04	150	125	6	CID000004197
Drug	sildenafil	PDE4A PDE4B PDE4D ABCC5 CARD14	1.89e-04	96	125	5	CID000005212
Drug	siguazodan	PDE4B PDE4C PDE4D	2.31e-04	22	125	3	CID000072124
Drug	guanine derivative	IMPDH2 AOX1 SRGN	2.64e-04	23	125	3	CID000129161
Disease	neuroimaging measurement	KIF26B TBC1D5 FAT3 SPTBN1 SPC25 ARHGAP35 ITGB5 ZNF462 IGF2BP1 SYNJ1 CSK SBNO1 NAV2 EIF2AK3 PLXNA2 EXOC4 ANKS1A	2.26e-06	1069	123	17	EFO_0004346
Disease	cerebral palsy (implicated_via_orthology)	AGAP7P AGAP4 AGAP6	8.30e-06	10	123	3	DOID:1969 (implicated_via_orthology)
Disease	progression free survival, response to carboplatin, methylcobalamin deficiency type cblE, ovarian serous carcinoma	PDE4B PDE4D IQGAP2 IGF2BP3	2.85e-05	42	123	4	EFO_0004920, EFO_1001516, GO_0097328, MONDO_0009354
Disease	Benign neoplasm of stomach	ATR POLE UBR5	4.61e-05	17	123	3	C0153943
Disease	Neoplasm of uncertain or unknown behavior of stomach	ATR POLE UBR5	4.61e-05	17	123	3	C0496905
Disease	Carcinoma in situ of stomach	ATR POLE UBR5	4.61e-05	17	123	3	C0154060
Disease	Early myoclonic encephalopathy	SIK1 SLC1A2	5.16e-05	3	123	2	cv:C0270855
Disease	Stomach Carcinoma	ATR POLE UBR5	8.90e-05	21	123	3	C0699791
Disease	acquired metabolic disease (implicated_via_orthology)	IGF2BP1 IGF2BP3	1.03e-04	4	123	2	DOID:0060158 (implicated_via_orthology)
Disease	brain measurement, neuroimaging measurement	KIF26B TBC1D5 FAT3 SPTBN1 SPC25 ZNF462 SBNO1 NAV2 EXOC4 ANKS1A	1.07e-04	550	123	10	EFO_0004346, EFO_0004464
Disease	late-onset Alzheimers disease	IQGAP2 FAT3 AOX1 METTL21EP ZNF462 CD33 SORL1	2.31e-04	292	123	7	EFO_1001870
Disease	primary ciliary dyskinesia (is_implicated_in)	DNAH7 BRWD1	2.56e-04	6	123	2	DOID:9562 (is_implicated_in)
Disease	Schizophrenia	PDE4A PDE4B PDE4D APBA2 ADNP2 SLC1A2 LMAN2L SBNO1 SYN2 ULK4 PIP4K2C PLXNA2	3.30e-04	883	123	12	C0036341
Disease	retinal detachment, retinal break	FRAS1 FAT3 RGL1	4.20e-04	35	123	3	EFO_0005773, EFO_0010698
Disease	lifestyle measurement	DOCK3 PDSS2 PDE4B SGSM2 HELZ EXOC4	4.68e-04	235	123	6	EFO_0010724
Disease	endometrial cancer (implicated_via_orthology)	ATR POLE	4.75e-04	8	123	2	DOID:1380 (implicated_via_orthology)
Disease	age at initiation of corrective lens use	TBC1D5 BRWD1	4.75e-04	8	123	2	EFO_0021781
Disease	progression free survival, response to carboplatin, methylcobalamin deficiency type cblE, ovarian carcinoma	PDE4B PDE4D IQGAP2	5.79e-04	39	123	3	EFO_0001075, EFO_0004920, GO_0097328, MONDO_0009354
Disease	smoking behavior	PDE4B NAV2 PLXNA2 EXOC4 EPHA7 SORL1 BRWD1	5.85e-04	341	123	7	EFO_0004318
Disease	venous thromboembolism	IQGAP2 KIF26B TBC1D5 PTPRT SBNO1 OTUD7A NAV2 BRWD1	7.09e-04	460	123	8	EFO_0004286
Disease	Adenocarcinoma of large intestine	POLE UBR5 MAP3K15 EPHA7	7.10e-04	96	123	4	C1319315
Disease	cortical thickness	TBC1D5 FAT3 SPTBN1 ARHGAP35 ITGB5 ZNF462 IGF2BP1 CSK NAV2 PLXNA2 EXOC4 EPHA7 ANKS1A	7.74e-04	1113	123	13	EFO_0004840
Disease	hepatocyte growth factor measurement	LDLRAP1 OTUD7A BRWD1	8.26e-04	44	123	3	EFO_0006903
Disease	metachronous colorectal adenoma	PDE4D FAT3 EPHA7	8.83e-04	45	123	3	EFO_0803377
Disease	anxiety disorder, stress-related disorder	PDE4B PTPRT	1.11e-03	12	123	2	EFO_0006788, EFO_0010098
Disease	Metastatic melanoma	SIK1 MAP3K15 EPHA7	1.50e-03	54	123	3	C0278883
Disease	fertility measurement	SIK1 NAV2	1.52e-03	14	123	2	EFO_0006923
Disease	immature platelet measurement	DOCK3 LDLRAP1 IQGAP2 TBC1D5	1.58e-03	119	123	4	EFO_0803541
Disease	infant head circumference	IGF2BP3 SBNO1	1.75e-03	15	123	2	EFO_0004577
Disease	N-acetylmethionine measurement	DOCK3 EPHA7	1.75e-03	15	123	2	EFO_0021427
Disease	Adenocarcinoma of lung (disorder)	IMPDH2 ATR ARHGAP35 MAP3K15 CMTR2	1.75e-03	206	123	5	C0152013
Disease	adverse effect, response to xenobiotic stimulus	FHOD3 NAV2 VWA3B	1.94e-03	59	123	3	EFO_0009658, GO_0009410
Disease	cup-to-disc ratio measurement	FRAS1 FHOD3 ARHGAP35 RGL1 PLEKHG3 NAV2 HELZ	2.22e-03	430	123	7	EFO_0006939
Disease	response to phenylephrine	PDE4B IQGAP2	2.25e-03	17	123	2	EFO_0010152
Disease	spinal stenosis	MGAT4D DYNC1I1	2.25e-03	17	123	2	EFO_0007490
Disease	osteoarthritis	KIF26B CSK SBNO1 DYNC1I1 TDRD12	2.43e-03	222	123	5	MONDO_0005178
Disease	Malignant neoplasm of endometrium	ATR POLE	2.52e-03	18	123	2	C0007103
Disease	Carcinoma in situ of endometrium	ATR POLE	2.52e-03	18	123	2	C0346191
Disease	hearing loss	IQGAP2 SPTBN1 PTPRK	2.79e-03	67	123	3	EFO_0004238
Disease	creatinine measurement	IMPDH2 ZNF607 KIF26B INTS8 RYR1 B4GALT1 FAP IGF2BP3 SYN2 SORL1 TDRD12	3.02e-03	995	123	11	EFO_0004518
Disease	number of teeth measurement	IGF2BP1 IGF2BP3	3.12e-03	20	123	2	EFO_0010073
Disease	Endometrial Carcinoma	PLXNA3 ATR POLE	3.42e-03	72	123	3	C0476089
Disease	haptoglobin measurement	DHX38 CMTR2	3.44e-03	21	123	2	EFO_0004640
Disease	eosinophil count	DOCK3 ATR TBC1D5 SPTBN1 SPC25 ABCC5 DNAH7 FAP IGF2BP1 SRGN CD33 CDC16 SYN2 VWA3B	3.68e-03	1488	123	14	EFO_0004842
Disease	lung cancer (is_implicated_in)	ATR CALR POLE	3.69e-03	74	123	3	DOID:1324 (is_implicated_in)
Disease	Dermatologic disorders	SFPQ PDE4B APBA2	3.84e-03	75	123	3	C0037274
Disease	Bipolar Disorder	PDE4A PDE4B CALR SLC1A2 LMAN2L ULK4 PIP4K2C	3.93e-03	477	123	7	C0005586
Disease	sensory peripheral neuropathy, remission	CACNB4 PTPRT	4.12e-03	23	123	2	EFO_0009785, MONDO_0002321

Protein segments in the cluster

Peptide	Gene	Start	Entry
DVMARDAHGNTALTY	AGAP4	626	Q96P64
NVESYLEEFDSMAHQ	EPG5	271	Q9HCE0
TENFLYHLAAAEQML	DENND10P1	341	Q6NSW5
FSDVDLIPMNDHNAY	B4GALT1	246	P15291
EYSSEHQAADMAEID	CCDC61	481	Q9Y6R9
EIHGRDDYSFNNTMA	CATSPERE	786	Q5SY80
MDHEDISESVDAAYN	EIF2AK3	746	Q9NZJ5
RDSAQMAYLTHFEED	ARMH1	421	Q6PIY5
ALHYAIDNENISMAR	ANKRD62	141	A6NC57
SYMLQDSLEHVQLFD	CLK3	581	P49761
ANTLNPYHEANDDLM	CMTR2	171	Q8IYT2
FENLMQLVEHYTSDA	CSK	146	P41240
EMYNDDLIHFSNSEN	APBA2	551	Q99767
DYHTDRQDIQKSMAA	ARHGEF7	426	Q14155
SNYQTEMGSALHEAA	ANKS1A	241	Q92625
DYQDTVNMLHSLLSA	CCNT1	656	O60563
SALAMADSDHLTIYN	DHX29	1126	Q7Z478
DHSSLGLEQLQDYMV	CCM2L	406	Q9NUG4
ASALMDLVQGVYHEN	PDSS2	216	Q86YH6
ERRSLMTSDENYHNE	CACNB4	451	O00305
NANASSQDALMYHIL	ADNP2	221	Q6IQ32
DVMARDAHGNTALTY	AGAP6	626	Q5VW22
NDGRILALDMEHYSN	AOX1	861	Q06278
LLNTTMDHLNEYAGE	ATP8B2	596	P98198
LMFEELSDIFSDHNN	RGL1	356	Q9NZL6
LQEQNSHDAMDSYYD	INTS8	916	Q75QN2
VLDTGLTAQDMHYAQ	LDLRAP1	271	Q5SW96
LEIENMGAHLNAYTS	PMPCB	121	O75439
YFSVSDMDHNHLDNQ	FRAS1	1806	Q86XX4
NMENHNSALAAEASE	HSFY1	221	Q96LI6
YENDVAAMSLQSHLI	IGF2BP1	351	Q9NZI8
TVEMDEELHYASLNF	CD33	331	P20138
SLDAMDKHLSSQNRY	IMPDH2	416	P12268
MVLTLEQAAGSEHYD	KIF26B	201	Q2KJY2
DLDMHALQRSTQYDG	HECTD2	666	Q5U5R9
ELMVASYNNNEDAPH	DYNC1I1	301	O14576
KNISDADVHNAMDNY	FEM1B	426	Q9UK73
IYDMLLSSENAHQRS	FSIP2	1361	Q5CZC0
AHIDPDASYMAAVNS	MLST8	176	Q9BVC4
DQDMNAYLAEQSRLH	PLXNA2	1826	O75051
MDAYLVEQSRLHASD	PLXNA3	1806	P51805
ELALMYNDESVLENH	PDE4A	491	P27815
ALMYNDESVLENHHL	PDE4B	466	Q07343
ELALMYNDASVLENH	PDE4C	446	Q08493
LALMYNDSSVLENHH	PDE4D	521	Q08499
SAMVNNGSLSYDHER	LMAN2L	176	Q9H0V9
NDFAFMLHLIDQYDS	LRRC8E	361	Q6NSJ5
SFHYLMDSEAQEDTR	METTL21EP	31	A6NDL7
MYQEHINEINAELSA	POLE	1406	Q07864
LAYDQAHFSALVSME	OTUD7A	361	Q8TE49
EDNYVTVMDLLAHAN	EPHA7	396	Q15375
NGDLVEYDADHMAQL	EXOC8	186	Q8IYI6
IDAASTEDLEYLMHA	HELZ	381	P42694
HLNEANEYTASNQMD	ITGB5	301	P18084
YENDIASMNLQAHLI	IGF2BP3	351	O00425
YSSMLNAKHLAEASQ	MGAT4D	211	A6NG13
EMSSDLHSLATFIYN	PTPRQ	521	Q9UMZ3
GESSNYINAALMDSH	PTPRT	1226	O14522
AHYDAMDNDIVQGAE	GOLIM4	481	O00461
THEELMNLNGDYATI	ABCC5	766	O15440
LNLMHDLSAYSDQFL	EXOC4	591	Q96A65
VESEHDQAMAAYFTA	CDC16	346	Q13042
DALIYMQVNSSFEDH	ATR	571	Q13535
RDMELLSNSLAAYAH	EVA1B	6	Q9NVM1
LELQMADSFDTGVYH	IGSF10	536	Q6WRI0
EALSHLYNESASTME	HEATR5A	1376	Q86XA9
TSLSQDHDAALMQGY	C2CD2	521	Q9Y426
DHDAALMQGYTASVD	C2CD2	526	Q9Y426
DEMLSLSLHYSNALQ	CARD14	196	Q9BXL6
DMHLQAENYTEAAFT	DOCK3	1246	Q8IZD9
YDTFNLHSLENSLMD	CPEB3	341	Q8NE35
DNIMALNNAFLDDSH	CPEB3	401	Q8NE35
SSSLNDEYGMHLENQ	CPLANE1	1631	Q9H799
DEYGMHLENQKLSSS	CPLANE1	1636	Q9H799
SIYDDMKNHRESNSN	SLC1A2	521	P43004
LAASSYIRDHLNAMN	DNAH7	261	Q8WXX0
SIDADSENNKMVHYQ	FAT3	2311	Q8TDW7
LSYAEDAAEHENMKA	FHOD3	1301	Q2V2M9
SLDQTDMHGDSEYNI	CALR	116	P27797
HYVAELNMDDLQSSA	DHRSX	186	Q8N5I4
DVMARDAHGNTALTY	AGAP7P	626	Q5VUJ5
GHSAEISDMAVNYEN	BRWD1	226	Q9NSI6
EMATFHTDAYLQHLQ	HDAC8	66	Q9BY41
TENFLYHLAAAEQML	DENND10	341	Q8TCE6
LDNISSFLDDHEENM	SCARA3	311	Q6AZY7
DALMHWLDQYNSSAD	SBNO1	1261	A3KN83
FETHTLEEHNLANYM	RYR1	4976	P21817
TNGYDQYDDLNMHLE	PRSS51	131	A0A1B0GVH4
DTDNYTHDVFMNDSL	DYNLT2B	116	Q8WW35
LNSLDEHTSEFYSMD	MYBL1	311	P10243
MDRSYADQSTLHAED	PTPRK	801	Q15262
SEDIADMHSNLSNYH	PIP4K2C	156	Q8TBX8
QAGDLEHMETRNYSA	OR13D1	26	Q8NGV5
FDMANNVILYHDTDA	MAP3K15	146	Q6ZN16
NTYSDNIIFRMEDGH	FREM3	511	P0C091
LNLVAHADGTYAVDM	SYN2	151	Q92777
NMDGSAAYHLVSEDV	SORL1	906	Q92673
ASEHAADIQMVNFDY	SYNJ1	321	O43426
LSLFDYEQLMAQEHS	PLEKHG3	986	A1L390
LDHDVDYQKLNSAMN	TDRD12	26	Q587J7
GENEHLSSMNNYLSE	IQGAP2	1156	Q13576
MEFIENLDALHSYLA	GUCY1B2	16	O75343
MLRTHSLSNADGQYD	NAV2	1586	Q8IVL1
LDSELFELMHQNGDY	SGSM2	891	O43147
MFDYLTSNGHLSENE	SIK1B	111	A0A0B4J2F2
MFDYLTSNGHLSENE	SIK1	111	P57059
NIIEATHMYDNAAEA	ARHGAP35	946	Q9NRY4
SQENAAYLPDMAEHD	PM20D2	191	Q8IYS1
MFSLHLNEARDYEVS	SPC25	171	Q9HBM1
LTAQDMSYDEARNLH	SPTBN1	1296	Q01082
FDFELTQHDMDNILS	AKR1E2	281	Q96JD6
NMNTADAAFYPDHAL	CNGA4	271	Q8IV77
SEMEDAYHEHQANLL	SFPQ	521	P23246
DDNLEHYKNSTVMAR	FAP	671	Q12884
DPDLMAYLSSLHQDN	ZBTB7B	311	O15156
VQTYTAMDLHADSLD	ZNF365	126	Q70YC5
DAQQDYHLEYAMENS	MOXD1	101	Q6UVY6
MASSVDEEALHQLYL	SPEF1	1	Q9Y4P9
DYSDDDTQEHKAQAM	VSTM2B	131	A6NLU5
MEQDYQLVDESDAFH	SRGN	116	P10124
MENYDNLVSLAGHSV	ZNF607	36	Q96SK3
YSAIIMDEAHERSLN	DHX38	646	Q92620
HLDYVMAAANLFAQT	UBA1	761	P22314
YALSNTAMELEFQAH	ZACN	176	Q401N2
EAMNVLNFDHSDLIY	ZNF462	911	Q96JM2
LEHDAYAVFSQLMET	TBC1D5	246	Q92609
QGHSDLEKMQDLYSE	VWA3B	686	Q502W6
YAESLSEAMEKSAHQ	UHRF1BP1	256	Q6BDS2
DFLNYALSLMRSHND	UBR5	1916	O95071
DSNMELLYEQGLVSH	ULK4	1066	Q96C45
VEDVLAAASYLHMND	ZBTB3	146	Q9H5J0
QAYMSNLESHSAILD	NDC80	311	O14777