Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	regulation of oxidoreductase activity	LGALS9C HIF1A ABL2 SZT2 LGALS9B ATP2B4	1.60e-07	84	60	6	GO:0051341
GeneOntologyBiologicalProcess	positive regulation of oxidoreductase activity	LGALS9C HIF1A ABL2 LGALS9B	9.63e-06	46	60	4	GO:0051353
GeneOntologyBiologicalProcess	calcium ion export	ATP2B1 ATP2B4	4.97e-05	4	60	2	GO:1901660
GeneOntologyBiologicalProcess	negative regulation of natural killer cell degranulation	LGALS9C LGALS9B	4.97e-05	4	60	2	GO:0043322
HumanPheno	Hyperuricemia	SLC12A3 SPTA1 LRP6 PPARG	5.85e-06	38	17	4	HP:0002149
HumanPheno	Increased circulating purine concentration	SLC12A3 SPTA1 LRP6 PPARG	1.64e-05	49	17	4	HP:0004368
HumanPheno	Abnormal circulating purine concentration	SLC12A3 SPTA1 LRP6 PPARG	2.80e-05	56	17	4	HP:0004352
HumanPheno	Gout	SLC12A3 SPTA1 LRP6	3.40e-05	20	17	3	HP:0001997
HumanPheno	Anterior concavity of thoracic vertebrae	FIG4 BCL11A	6.27e-05	4	17	2	HP:0004611
HumanPheno	Low-to-normal blood pressure	SLC12A3 KCNJ1	6.27e-05	4	17	2	HP:0002632
HumanPheno	Abnormal circulating nucleobase concentration	SLC12A3 SPTA1 LRP6 PPARG	8.47e-05	74	17	4	HP:0010932
HumanPheno	Increased blood pressure	XYLT1 SLC12A3 INF2 FIG4 KCNJ1 LRP6 CCND1 PPARG	9.97e-05	508	17	8	HP:0032263
HumanPheno	Hypertension	XYLT1 SLC12A3 INF2 FIG4 KCNJ1 LRP6 CCND1 PPARG	9.97e-05	508	17	8	HP:0000822
HumanPheno	Onion bulb formation	GBF1 INF2 FIG4	1.44e-04	32	17	3	HP:0003383
HumanPheno	Renal potassium wasting	SLC12A3 KCNJ1	1.56e-04	6	17	2	HP:0000128
HumanPheno	Azotemia	SLC12A3 SPTA1 LRP6 CCND1 PPARG	2.16e-04	178	17	5	HP:0002157
HumanPheno	Abnormal systemic blood pressure	XYLT1 SLC12A3 INF2 FIG4 KCNJ1 LRP6 CCND1 PPARG	2.24e-04	569	17	8	HP:0030972
MousePheno	increased susceptibility to induced arthritis	LGALS9C LGALS9B TNFSF10 PPARG	8.49e-06	36	51	4	MP:0003724
MousePheno	macrodontia	FIG4 LRP6 CCND1	2.48e-05	16	51	3	MP:0030091
MousePheno	long incisors	FIG4 LRP6 CCND1	2.48e-05	16	51	3	MP:0004831
MousePheno	increased B cell proliferation	LGALS9C LGALS9B SPTA1 PPARG	1.58e-04	75	51	4	MP:0005154
MousePheno	delayed liver regeneration	HIF1A IGFBP1	1.94e-04	6	51	2	MP:0031324
MousePheno	increased chromosomal stability	ZSCAN5A ZSCAN5C	1.94e-04	6	51	2	MP:0010095
MousePheno	lymph node hyperplasia	LGALS9C LGALS9B SPTA1	2.31e-04	33	51	3	MP:0008102
MousePheno	thymus hyperplasia	LGALS9C LGALS9B TNFSF10	2.53e-04	34	51	3	MP:0000708
Domain	ATP2B1/4	ATP2B1 ATP2B4	1.01e-05	2	60	2	IPR030319
Domain	ATP_Ca_trans_C	ATP2B1 ATP2B4	6.06e-05	4	60	2	IPR022141
Domain	ATP_Ca_trans_C	ATP2B1 ATP2B4	6.06e-05	4	60	2	PF12424
Domain	P-type_ATPase_IIB	ATP2B1 ATP2B4	6.06e-05	4	60	2	IPR006408
Domain	Atypical_DUSP	DUSP26 DUSP18	7.74e-04	13	60	2	IPR020417
Domain	Gal-bind_lectin	LGALS9C LGALS9B	1.04e-03	15	60	2	PF00337
Domain	Gal-bind_lectin	LGALS9C LGALS9B	1.04e-03	15	60	2	SM00908
Domain	GALECTIN	LGALS9C LGALS9B	1.04e-03	15	60	2	PS51304
Domain	Galectin_CRD	LGALS9C LGALS9B	1.04e-03	15	60	2	IPR001079
Domain	GLECT	LGALS9C LGALS9B	1.04e-03	15	60	2	SM00276
Domain	-	ATP2B1 ATP2B4	1.18e-03	16	60	2	1.20.1110.10
Domain	ATPase_P-typ_TM_dom	ATP2B1 ATP2B4	1.18e-03	16	60	2	IPR023298
Domain	ATPase_P-typ_cation-transptr_C	ATP2B1 ATP2B4	1.34e-03	17	60	2	IPR006068
Domain	Cation_ATPase_C	ATP2B1 ATP2B4	1.34e-03	17	60	2	PF00689
Domain	Cation_ATPase_N	ATP2B1 ATP2B4	1.50e-03	18	60	2	PF00690
Domain	Cation_ATPase_N	ATP2B1 ATP2B4	1.50e-03	18	60	2	SM00831
Domain	Tyr_Pase_AS	DUSP26 DUSP18 PTPRK	1.67e-03	73	60	3	IPR016130
Domain	ATPase_P-typ_cation-transptr_N	ATP2B1 ATP2B4	1.68e-03	19	60	2	IPR004014
Domain	TYR_PHOSPHATASE_1	DUSP26 DUSP18 PTPRK	2.67e-03	86	60	3	PS00383
Domain	TYR_PHOSPHATASE_2	DUSP26 DUSP18 PTPRK	2.76e-03	87	60	3	PS50056
Domain	TYR_PHOSPHATASE_dom	DUSP26 DUSP18 PTPRK	2.76e-03	87	60	3	IPR000387
Domain	-	DUSP26 DUSP18 PTPRK	3.23e-03	92	60	3	3.90.190.10
Domain	Prot-tyrosine_phosphatase-like	DUSP26 DUSP18 PTPRK	3.97e-03	99	60	3	IPR029021
Domain	DUSP	DUSP26 DUSP18	4.44e-03	31	60	2	IPR024950
Domain	TYR_PHOSPHATASE_DUAL	DUSP26 DUSP18	5.33e-03	34	60	2	PS50054
Domain	bZIP_1	CREB3L4 CREB3L1	5.33e-03	34	60	2	PF00170
Domain	TYR_PHOSPHATASE_DUAL_dom	DUSP26 DUSP18	5.64e-03	35	60	2	IPR020422
Domain	DSPc	DUSP26 DUSP18	5.64e-03	35	60	2	SM00195
Domain	ATPase_P-typ_cyto_domN	ATP2B1 ATP2B4	5.64e-03	35	60	2	IPR023299
Domain	P_typ_ATPase	ATP2B1 ATP2B4	5.96e-03	36	60	2	IPR001757
Domain	ATPase_P-typ_P_site	ATP2B1 ATP2B4	5.96e-03	36	60	2	IPR018303
Domain	ATPASE_E1_E2	ATP2B1 ATP2B4	5.96e-03	36	60	2	PS00154
Domain	ATPase_P-typ_transduc_dom_A	ATP2B1 ATP2B4	6.29e-03	37	60	2	IPR008250
Domain	E1-E2_ATPase	ATP2B1 ATP2B4	6.29e-03	37	60	2	PF00122
Domain	TF_DNA-bd	CREB3L4 CREB3L1	6.29e-03	37	60	2	IPR008917
Pubmed	The glucose transporter 2 regulates CD8+ T cell function via environment sensing.	LGALS9C HIF1A LGALS9B	5.12e-08	5	61	3	37884694
Pubmed	Association of rs11643718 SLC12A3 and rs741301 ELMO1 Variants with Diabetic Nephropathy in South Indian Population.	SLC12A3 ELMO1	3.03e-06	2	61	2	27699784
Pubmed	Functional and structural demonstration of the presence of Ca-ATPase (PMCA) in both microvillous and basal plasma membranes from syncytiotrophoblast of human term placenta.	ATP2B1 ATP2B4	3.03e-06	2	61	2	18657858
Pubmed	HIF1α-mediated TRAIL Expression Regulates Lacrimal Gland Inflammation in Dry Eye Disease.	HIF1A TNFSF10	3.03e-06	2	61	2	31995154
Pubmed	Time-dependent PPARγ Modulation of HIF-1α Signaling in Hypoxic Pulmonary Artery Smooth Muscle Cells.	HIF1A PPARG	3.03e-06	2	61	2	27432037
Pubmed	Hypoxia induces peroxisome proliferator-activated receptor γ expression via HIF-1-dependent mechanisms in HepG2 cell line.	HIF1A PPARG	3.03e-06	2	61	2	24374034
Pubmed	Novel treatment option for MUC16-positive malignancies with the targeted TRAIL-based fusion protein Meso-TR3.	TNFSF10 MUC16	3.03e-06	2	61	2	24447304
Pubmed	The single nucleotide polymorphism rs11643718 in SLC12A3 is associated with the development of diabetic kidney disease in Chinese people with type 2 diabetes.	SLC12A3 ELMO1	3.03e-06	2	61	2	32634861
Pubmed	Carnosine decreases IGFBP1 production in db/db mice through suppression of HIF-1.	HIF1A IGFBP1	3.03e-06	2	61	2	25869614
Pubmed	HIF-2α attenuates lymphangiogenesis by up-regulating IGFBP1 in hepatocellular carcinoma.	HIF1A IGFBP1	3.03e-06	2	61	2	25757011
Pubmed	Cyclin D1 repression of peroxisome proliferator-activated receptor gamma expression and transactivation.	CCND1 PPARG	3.03e-06	2	61	2	12917338
Pubmed	Targeted ablation of plasma membrane Ca2+-ATPase (PMCA) 1 and 4 indicates a major housekeeping function for PMCA1 and a critical role in hyperactivated sperm motility and male fertility for PMCA4.	ATP2B1 ATP2B4	3.03e-06	2	61	2	15178683
Pubmed	Regulation of plasma membrane Ca2+-ATPase by small GTPases and phosphoinositides in human platelets.	ATP2B1 ATP2B4	3.03e-06	2	61	2	10748016
Pubmed	Oxysterol-binding protein-like 3 is a novel target gene of peroxisome proliferator-activated receptor γ in fatty liver disease.	OSBPL3 PPARG	3.03e-06	2	61	2	36781118
Pubmed	Downregulation of fatty acid oxidation by involvement of HIF-1α and PPARγ in human gastric adenocarcinoma and related clinical significance.	HIF1A PPARG	3.03e-06	2	61	2	33730333
Pubmed	Plasma membrane calcium ATPase regulates bone mass by fine-tuning osteoclast differentiation and survival.	ATP2B1 ATP2B4	3.03e-06	2	61	2	23266958
Pubmed	Common genetic variants at the 11q13.3 renal cancer susceptibility locus influence binding of HIF to an enhancer of cyclin D1 expression.	HIF1A CCND1	3.03e-06	2	61	2	22406644
Pubmed	The influence of membrane lipid structure on plasma membrane Ca2+ -ATPase activity.	ATP2B1 ATP2B4	3.03e-06	2	61	2	16412504
Pubmed	Distinct roles of PMCA isoforms in Ca2+ homeostasis of bladder smooth muscle: evidence from PMCA gene-ablated mice.	ATP2B1 ATP2B4	3.03e-06	2	61	2	16956963
Pubmed	Localization of two genes encoding plasma membrane Ca2(+)-transporting ATPases to human chromosomes 1q25-32 and 12q21-23.	ATP2B1 ATP2B4	3.03e-06	2	61	2	1674727
Pubmed	PPARγ Modulation of Cytokine-Stimulated MUC16 (CA125) Expression in Breast and Ovarian Cancer-Derived Cells.	MUC16 PPARG	3.03e-06	2	61	2	27292441
Pubmed	Role of plasma membrane Ca2+-ATPase in contraction-relaxation processes of the bladder: evidence from PMCA gene-ablated mice.	ATP2B1 ATP2B4	3.03e-06	2	61	2	16291816
Pubmed	Selective upregulation of the expression of plasma membrane calcium ATPase isoforms upon differentiation and 1,25(OH)2D3-vitamin treatment of colon cancer cells.	ATP2B1 ATP2B4	3.03e-06	2	61	2	26116539
Pubmed	Galectin-9 is a high affinity IgE-binding lectin with anti-allergic effect by blocking IgE-antigen complex formation.	LGALS9C LGALS9B	9.07e-06	3	61	2	19776007
Pubmed	Galectin-9 regulates follicular helper T cells to inhibit humoral autoimmunity-induced pulmonary fibrosis.	LGALS9C LGALS9B	9.07e-06	3	61	2	33316546
Pubmed	Identification and characterization of galectin-9, a novel beta-galactoside-binding mammalian lectin.	LGALS9C LGALS9B	9.07e-06	3	61	2	9038233
Pubmed	Protective effect of Galectin-9 in murine model of lung emphysema: Involvement of neutrophil migration and MMP-9 production.	LGALS9C LGALS9B	9.07e-06	3	61	2	28704475
Pubmed	Galectin-9 protein is up-regulated in astrocytes by tumor necrosis factor and promotes encephalitogenic T-cell apoptosis.	LGALS9C LGALS9B	9.07e-06	3	61	2	23836896
Pubmed	Sequence and mapping of galectin-5, a beta-galactoside-binding lectin, found in rat erythrocytes.	LGALS9C LGALS9B	9.07e-06	3	61	2	7890611
Pubmed	Galectin-9 suppresses Th17 cell development in an IL-2-dependent but Tim-3-independent manner.	LGALS9C LGALS9B	9.07e-06	3	61	2	22341088
Pubmed	Galectin-9 Is a Novel Regulator of Epithelial Restitution.	LGALS9C LGALS9B	9.07e-06	3	61	2	32380082
Pubmed	Galectin-9-mediated protection from allo-specific T cells as a mechanism of immune privilege of corneal allografts.	LGALS9C LGALS9B	9.07e-06	3	61	2	23667648
Pubmed	Regulatory T Cell-Mediated Suppression of Inflammation Induced by DR3 Signaling Is Dependent on Galectin-9.	LGALS9C LGALS9B	9.07e-06	3	61	2	28877989
Pubmed	Galectin-9 ameliorates immune complex-induced arthritis by regulating Fc gamma R expression on macrophages.	LGALS9C LGALS9B	9.07e-06	3	61	2	19800850
Pubmed	A complex of Neuroplastin and Plasma Membrane Ca2+ ATPase controls T cell activation.	ATP2B1 ATP2B4	9.07e-06	3	61	2	28827723
Pubmed	The effect of Toxoplasma gondii infection on galectin-9 expression in decidual macrophages contributing to dysfunction of decidual NK cells during pregnancy.	LGALS9C LGALS9B	9.07e-06	3	61	2	38987795
Pubmed	Oncogenic miR-93-5p/Gal-9 axis drives CD8 (+) T-cell inactivation and is a therapeutic target for hepatocellular carcinoma immunotherapy.	LGALS9C LGALS9B	9.07e-06	3	61	2	37105392
Pubmed	Contributions of rare coding variants in hypotension syndrome genes to population blood pressure variation.	SLC12A3 KCNJ1	9.07e-06	3	61	2	30113482
Pubmed	Galectin-9/Tim-3 pathway mediates dopaminergic neurodegeneration in MPTP-induced mouse model of Parkinson's disease.	LGALS9C LGALS9B	9.07e-06	3	61	2	36479526
Pubmed	Profiling Lgals9 splice variant expression at the fetal-maternal interface: implications in normal and pathological human pregnancy.	LGALS9C LGALS9B	9.07e-06	3	61	2	23242525
Pubmed	Galectin-9 in allergic airway inflammation and hyper-responsiveness in mice.	LGALS9C LGALS9B	9.07e-06	3	61	2	19851072
Pubmed	The Role of Galectin-9 as Mediator of Atopic Dermatitis: Effect on Keratinocytes.	LGALS9C LGALS9B	9.07e-06	3	61	2	33923930
Pubmed	Intracellular Galectin-9 Enhances Proximal TCR Signaling and Potentiates Autoimmune Diseases.	LGALS9C LGALS9B	9.07e-06	3	61	2	31969388
Pubmed	Obesity-induced galectin-9 is a therapeutic target in B-cell acute lymphoblastic leukemia.	LGALS9C LGALS9B	9.07e-06	3	61	2	35241678
Pubmed	Possible regulatory role of galectin-9 on Ascaris suum-induced eosinophilic lung inflammation in mice.	LGALS9C LGALS9B	9.07e-06	3	61	2	22627368
Pubmed	Galectin-9 is required for endometrial regenerative cells to induce long-term cardiac allograft survival in mice.	LGALS9C LGALS9B	9.07e-06	3	61	2	33153471
Pubmed	T cell immunoglobulin and mucin protein-3 (Tim-3)/Galectin-9 interaction regulates influenza A virus-specific humoral and CD8 T-cell responses.	LGALS9C LGALS9B	9.07e-06	3	61	2	22052881
Pubmed	Galectin-9 supports primary T cell transendothelial migration in a glycan and integrin dependent manner.	LGALS9C LGALS9B	9.07e-06	3	61	2	35643073
Pubmed	Galectin-9 functionally impairs natural killer cells in humans and mice.	LGALS9C LGALS9B	9.07e-06	3	61	2	23408620
Pubmed	Peroxisome proliferator-activated receptor gamma activation modulates cyclin D1 transcription via beta-catenin-independent and cAMP-response element-binding protein-dependent pathways in mouse hepatocytes.	CCND1 PPARG	9.07e-06	3	61	2	14764597
Pubmed	Galectin-9 Is Critical for Mucosal Adaptive Immunity through the T Helper 17-IgA Axis.	LGALS9C LGALS9B	9.07e-06	3	61	2	29458010
Pubmed	Xanthine oxidoreductase promotes the inflammatory state of mononuclear phagocytes through effects on chemokine expression, peroxisome proliferator-activated receptor-{gamma} sumoylation, and HIF-1{alpha}.	HIF1A PPARG	9.07e-06	3	61	2	21059659
Pubmed	Cooperative Interactions of Oligosaccharide and Peptide Moieties of a Glycopeptide Derived from IgE with Galectin-9.	LGALS9C LGALS9B	9.07e-06	3	61	2	26582205
Pubmed	Developmental regulation, expression, and apoptotic potential of galectin-9, a beta-galactoside binding lectin.	LGALS9C LGALS9B	9.07e-06	3	61	2	9153289
Pubmed	Galectin-9 expands unique macrophages exhibiting plasmacytoid dendritic cell-like phenotypes that activate NK cells in tumor-bearing mice.	LGALS9C LGALS9B	9.07e-06	3	61	2	18974023
Pubmed	OASIS modulates hypoxia pathway activity to regulate bone angiogenesis.	HIF1A CREB3L1	9.07e-06	3	61	2	26558437
Pubmed	Cell surface galectin-9 expressing Th cells regulate Th17 and Foxp3+ Treg development by galectin-9 secretion.	LGALS9C LGALS9B	9.07e-06	3	61	2	23144904
Pubmed	Impaired Gal-9 Dysregulates the PBMC-Induced Th1/Th2 Imbalance in Abortion-Prone Matings.	LGALS9C LGALS9B	9.07e-06	3	61	2	29651447
Pubmed	The N- and C-terminal carbohydrate recognition domains of galectin-9 contribute differently to its multiple functions in innate immunity and adaptive immunity.	LGALS9C LGALS9B	9.07e-06	3	61	2	21146220
Pubmed	Loss of von Hippel-Lindau protein causes cell density dependent deregulation of CyclinD1 expression through hypoxia-inducible factor.	HIF1A CCND1	9.07e-06	3	61	2	12743597
Pubmed	Hypoxia-induced HIF1A activates DUSP18-mediated MAPK14 dephosphorylation to promote hepatocellular carcinoma cell migration and invasion.	DUSP18 HIF1A	9.07e-06	3	61	2	35841693
Pubmed	Regulation of M1‑type and M2‑type macrophage polarization in RAW264.7 cells by Galectin‑9.	LGALS9C LGALS9B	9.07e-06	3	61	2	28990062
Pubmed	Galectin-9 suppresses tumor metastasis by blocking adhesion to endothelium and extracellular matrices.	LGALS9C LGALS9B	9.07e-06	3	61	2	18579572
Pubmed	Crystal structure of the galectin-9 N-terminal carbohydrate recognition domain from Mus musculus reveals the basic mechanism of carbohydrate recognition.	LGALS9C LGALS9B	9.07e-06	3	61	2	16990264
Pubmed	Plasma membrane Ca2+ ATPase 1 (PMCA1) but not PMCA4 is critical for B-cell development and Ca2+ homeostasis in mice.	ATP2B1 ATP2B4	9.07e-06	3	61	2	33098669
Pubmed	Structural analysis of the human galectin-9 N-terminal carbohydrate recognition domain reveals unexpected properties that differ from the mouse orthologue.	LGALS9C LGALS9B	9.07e-06	3	61	2	18005988
Pubmed	Galectin-9 ameliorates clinical severity of MRL/lpr lupus-prone mice by inducing plasma cell apoptosis independently of Tim-3.	LGALS9C LGALS9B	9.07e-06	3	61	2	23585851
Pubmed	Galectin-9 ameliorates anti-GBM glomerulonephritis by inhibiting Th1 and Th17 immune responses in mice.	LGALS9C LGALS9B	9.07e-06	3	61	2	24477688
Pubmed	A unique role for galectin-9 in angiogenesis and inflammatory arthritis.	LGALS9C LGALS9B	9.07e-06	3	61	2	29433546
Pubmed	Evodiamine inhibits the proliferation of leukemia cell line K562 by regulating peroxisome proliferators-activated receptor gamma (PPARγ) pathway.	CCND1 PPARG	9.07e-06	3	61	2	26671528
Pubmed	Alarmin function of galectin-9 in murine respiratory tularemia.	LGALS9C LGALS9B	9.07e-06	3	61	2	25898318
Pubmed	Amelioration of bleomycin-induced pulmonary fibrosis via TGF-β-induced Smad and non-Smad signaling pathways in galectin-9-deficient mice and fibroblast cells.	LGALS9C LGALS9B	9.07e-06	3	61	2	31937306
Pubmed	Intestinal epithelial cells express galectin-9 in patients with food allergy that plays a critical role in sustaining allergic status in mouse intestine.	LGALS9C LGALS9B	9.07e-06	3	61	2	21426359
Pubmed	Galectin-9 suppresses the generation of Th17, promotes the induction of regulatory T cells, and regulates experimental autoimmune arthritis.	LGALS9C LGALS9B	9.07e-06	3	61	2	18282810
Pubmed	Galectin-9 is a suppressor of T and B cells and predicts the immune modulatory potential of mesenchymal stromal cell preparations.	LGALS9C LGALS9B	9.07e-06	3	61	2	24083426
Pubmed	Galectin-9 in synergy with NF-κB inhibition restores immune regulatory capability in dendritic cells of subjects with food allergy.	LGALS9C LGALS9B	9.07e-06	3	61	2	37279535
Pubmed	The protective function of galectin-9 in liver ischemia and reperfusion injury in mice.	LGALS9C LGALS9B	9.07e-06	3	61	2	25931247
Pubmed	Galectin-9 protects mice from the Shwartzman reaction by attracting prostaglandin E2-producing polymorphonuclear leukocytes.	LGALS9C LGALS9B	9.07e-06	3	61	2	17560833
Pubmed	CD22 attenuates calcium signaling by potentiating plasma membrane calcium-ATPase activity.	ATP2B1 ATP2B4	9.07e-06	3	61	2	15133509
Pubmed	SARS-Cov-2 spike induces intestinal barrier dysfunction through the interaction between CEACAM5 and Galectin-9.	LGALS9C LGALS9B	1.81e-05	4	61	2	38686388
Pubmed	Cell-specific expression of plasma membrane calcium ATPase isoforms in retinal neurons.	ATP2B1 ATP2B4	1.81e-05	4	61	2	12209837
Pubmed	Contrasting acute graft-versus-host disease effects of Tim-3/galectin-9 pathway blockade dependent upon the presence of donor regulatory T cells.	LGALS9C LGALS9B	1.81e-05	4	61	2	22677125
Pubmed	Role of Tim-3/galectin-9 inhibitory interaction in viral-induced immunopathology: shifting the balance toward regulators.	LGALS9C LGALS9B	1.81e-05	4	61	2	19234217
Pubmed	Zscan5b Deficiency Impairs DNA Damage Response and Causes Chromosomal Aberrations during Mitosis.	ZSCAN5A ZSCAN5C	1.81e-05	4	61	2	31155506
Pubmed	Expression and role of calcium-ATPase pump and sodium-calcium exchanger in differentiated trophoblasts from human term placenta.	ATP2B1 ATP2B4	1.81e-05	4	61	2	12784250
Pubmed	Tim-3/Galectin-9 signaling pathway is involved in the cytokine changes in mice with alveolar echinococcosis.	LGALS9C LGALS9B	1.81e-05	4	61	2	35715604
Pubmed	Galectin-9 increases Tim-3+ dendritic cells and CD8+ T cells and enhances antitumor immunity via galectin-9-Tim-3 interactions.	LGALS9C LGALS9B	1.81e-05	4	61	2	19017954
Pubmed	Galectin-9: A novel promoter of atherosclerosis progression.	LGALS9C LGALS9B	1.81e-05	4	61	2	36459823
Pubmed	MUC16 mucin (CA125) attenuates TRAIL-induced apoptosis by decreasing TRAIL receptor R2 expression and increasing c-FLIP expression.	TNFSF10 MUC16	1.81e-05	4	61	2	24690311
Pubmed	The plasma membrane calcium pump in health and disease.	ATP2B1 ATP2B4	1.81e-05	4	61	2	23413890
Pubmed	Quantitative analysis of alternative splicing options of human plasma membrane calcium pump genes.	ATP2B1 ATP2B4	1.81e-05	4	61	2	8245032
Pubmed	Galectin-9 inhibits TLR7-mediated autoimmunity in murine lupus models.	LGALS9C LGALS9B	1.81e-05	4	61	2	29611821
Pubmed	Lgals9 deficiency ameliorates obesity by modulating redox state of PRDX2.	LGALS9C LGALS9B	1.81e-05	4	61	2	33727589
Pubmed	The Galectin-9/Tim-3 pathway is involved in the regulation of NK cell function at the maternal-fetal interface in early pregnancy.	LGALS9C LGALS9B	1.81e-05	4	61	2	25578313
Pubmed	Quantitative analysis of alternative splicing options of human plasma membrane calcium pump genes.	ATP2B1 ATP2B4	1.81e-05	4	61	2	7989379
Pubmed	Role of alternative splicing in generating isoform diversity among plasma membrane calcium pumps.	ATP2B1 ATP2B4	1.81e-05	4	61	2	11152753
Pubmed	[Expression and significance of galectin-3 and galectin-9 in mice nasal mucosa with allergic rhinitis].	LGALS9C LGALS9B	1.81e-05	4	61	2	18826117
Pubmed	The expression of Galectin-9 correlates with mTOR and AMPK in murine colony-forming erythroid progenitors.	LGALS9C LGALS9B	1.81e-05	4	61	2	38853593
Pubmed	Gankyrin facilitates follicle-stimulating hormone-driven ovarian cancer cell proliferation through the PI3K/AKT/HIF-1α/cyclin D1 pathway.	HIF1A CCND1	1.81e-05	4	61	2	26364616
Pubmed	PMCA1 depletion in mouse eggs amplifies calcium signaling and impacts offspring growth†.	ATP2B1 ATP2B4	1.81e-05	4	61	2	36130203
Interaction	C17orf78 interactions	GBF1 ATP2B1 ATP2B4	4.89e-06	12	58	3	int:C17orf78
Cytoband	19q13.43	ZSCAN5A ZSCAN5C ZNF582	2.18e-04	87	61	3	19q13.43
Cytoband	1q25.2	ABL2 TOR3A	7.88e-04	31	61	2	1q25.2
GeneFamily	ATPases Ca2+ transporting	ATP2B1 ATP2B4	2.25e-04	9	46	2	1209
GeneFamily	Galectins	LGALS9C LGALS9B	6.51e-04	15	46	2	629
GeneFamily	Atypical dual specificity phosphatases	DUSP26 DUSP18	9.44e-04	18	46	2	896
Coexpression	GSE43863_DAY6_EFF_VS_DAY150_MEM_TFH_CD4_TCELL_UP	HIF1A LGALS9B PLAC8L1 OSBPL3 INO80 ATP2B1	6.32e-06	199	60	6	M9745
Coexpression	GSE3720_UNSTIM_VS_LPS_STIM_VD1_GAMMADELTA_TCELL_DN	PLSCR4 PLCZ1 FIG4 OSBPL3 ATP2B1	2.14e-05	146	60	5	M6341
CoexpressionAtlas	dev gonad_e13.5_M_InterstitTestis_Sma_k-means-cluster#1_top-relative-expression-ranked_100	CLCA2 MUC16 CREB3L1	5.68e-05	27	59	3	gudmap_dev gonad_e13.5_M_InterstitTestis_Sma_k1_100
CoexpressionAtlas	dev gonad_e13.5_M_InterstitTestis_Sma_top-relative-expression-ranked_100	CLCA2 MUC16 ATP2B4 CREB3L1	5.94e-05	76	59	4	gudmap_dev gonad_e13.5_M_InterstitTestis_Sma_100
CoexpressionAtlas	dev gonad_e13.5_F_VascAssocMesenchStromOvary_Sma_k-means-cluster#4_top-relative-expression-ranked_100	CLCA2 MUC16 CREB3L1	7.84e-05	30	59	3	gudmap_dev gonad_e13.5_F_VascAssocMesenchStromOvary_Sma_k4_100
CoexpressionAtlas	dev gonad_e13.5_F_VascAssocMesenchStromOvary_MafB_k-means-cluster#1_top-relative-expression-ranked_200	CLCA2 MUC16 CREB3L1	1.05e-04	33	59	3	gudmap_dev gonad_e13.5_F_VascAssocMesenchStromOvary_MafB_k1_200
ToppCell	E18.5-samps-Mesenchymal-Matrix_fibroblast-MatrixFB-A\|E18.5-samps / Age Group, Lineage, Cell class and subclass	CLK1 MICAL3 ATP2B4 CREB3L1 ELMO1	3.05e-06	164	61	5	519ab4fe885dfe4c50846f346a062acc2cb44299
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)-Goblet_(subsegmental)_L.0.4.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CLCA2 TNFSF10 MUC16 CREB3L4 CREB3L1	3.34e-06	167	61	5	31633899aae852873a4887e72c621474b0a51a33
ToppCell	Control-B_cells-Activated_B_cells\|Control / group, cell type (main and fine annotations)	SESN3 MICAL3 BCL11A ATP2B1 ELMO1	3.44e-06	168	61	5	a7159a35fe37f8c241cf8d391debe271e0698105
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CLCA2 TNFSF10 MUC16 CREB3L4 CREB3L1	3.96e-06	173	61	5	3aa1d28d4814798a772808ed29e1dbbdf92abd03
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CLCA2 TNFSF10 MUC16 CREB3L4 CREB3L1	3.96e-06	173	61	5	e8afef5ae68983eb8d6515b43952636a47e9d3d4
ToppCell	3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)-Goblet_(subsegmental)_L.0.4.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CLCA2 TNFSF10 MUC16 CREB3L4 CREB3L1	7.10e-06	195	61	5	2a9a36df1dbc4eac77a8ddbe939ec8a8d6c41464
ToppCell	3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CLCA2 TNFSF10 MUC16 CREB3L4 CREB3L1	7.10e-06	195	61	5	576142b4e75457c0973051bccc4163bd624496af
ToppCell	3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CLCA2 TNFSF10 MUC16 CREB3L4 CREB3L1	7.10e-06	195	61	5	8f151066ad3ebd9661ea0b733f03c2ce1518f9ad
ToppCell	COVID-19-Epithelial-Club,_Basal_cells\|COVID-19 / Condition, Lineage and Cell class	CLCA2 PTPRK MUC16 RAI14 CREB3L1	7.28e-06	196	61	5	dd32046067d93b9484cfbf1d7826a436a3d9f0e9
ToppCell	BAL-Mild-Epithelial-Epithelial-Basal/Club-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CLCA2 MUC16 RAI14 CCND1 CREB3L1	7.28e-06	196	61	5	a4d05d85fbafa869df19bba3881020ea433d81fb
ToppCell	BAL-Mild-Epithelial-Epithelial-Basal/Club-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	CLCA2 MUC16 RAI14 CCND1 CREB3L1	7.28e-06	196	61	5	91a3c3091064f1f5a3bdc1dd5883fc24dce8ff05
ToppCell	BAL-Mild-Epithelial-Epithelial-Basal/Club\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CLCA2 MUC16 RAI14 CCND1 CREB3L1	7.28e-06	196	61	5	e819088a74d29e958371aa851ac9c74ec55367b7
ToppCell	BAL-Mild-Epithelial-Epithelial-Basal/Club\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	CLCA2 MUC16 RAI14 CCND1 CREB3L1	7.28e-06	196	61	5	e675d661b6494ac3a85ba7ee5bdeaa98b8bbe957
ToppCell	COVID-19-Epithelial-Club,_Basal_cells\|Epithelial / Condition, Lineage and Cell class	CLCA2 LGALS9B TNFSF10 MUC16 CREB3L1	7.46e-06	197	61	5	78ed2810e5a765327e7a6da0ca5d4854bf7a0b6f
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CLCA2 TNFSF10 MUC16 CREB3L4 CREB3L1	7.46e-06	197	61	5	ff19e4c45715752a04541ad6a0cdf5454c9daaa2
ToppCell	Mild_COVID-19-Epithelial-Basal/Club\|Mild_COVID-19 / Disease group,lineage and cell class （2021.01.30）	CLCA2 MUC16 RAI14 CCND1 CREB3L1	7.46e-06	197	61	5	4cc5b778e1e2c6c149160fa147c172977c0fa8eb
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-club_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CLCA2 TNFSF10 MUC16 CREB3L4 CREB3L1	7.64e-06	198	61	5	778fee7020c82d11ff3984a8e482a23e5d58165f
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)-Club_(non-nasal)_L.0.4.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CLCA2 TNFSF10 MUC16 CREB3L4 CREB3L1	7.64e-06	198	61	5	7896f9fb89822e8628fe0b90a489c4760c7b876c
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L2/3_IT-L2/3_IT_ALM_Macc1_Lrg1\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	DUSP18 PPARG PREX1 ATP2B4	4.32e-05	142	61	4	d08e1880425d285c4433014fe0242ac7ff7734af
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L2/3_IT\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	DUSP18 PTPRK PREX1 ATP2B4	5.07e-05	148	61	4	d5cace5605bff2bb8248fadb51f2dad7539930ba
ToppCell	Transverse-Dendritic_cell-cDC1\|Dendritic_cell / Region, Cell class and subclass	DUSP18 CLK1 CCND1 BCL11A	5.48e-05	151	61	4	6870f3b5d2bfad849c3203658b5f28f0ae181295
ToppCell	368C-Endothelial_cells-Endothelial-E\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	XYLT1 DUSP26 PTPRK TNFSF10	6.22e-05	156	61	4	4877aabf647238c0279e497345b6a6d5ee07ef9c
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L2/3_IT-L2/3_IT_VISp_Agmat\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	DUSP18 PTPRK PREX1 ATP2B4	6.22e-05	156	61	4	09e0702400570089d9012dcf94dfb4827c97e49d
ToppCell	368C-Endothelial_cells-Endothelial-E-\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	XYLT1 DUSP26 PTPRK TNFSF10	6.22e-05	156	61	4	1d681fa17e62815f5d5f90c86be3c248b38e011b
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L2/3_IT-L2/3_IT_VISp_Adamts2\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	DUSP18 PTPRK PREX1 ATP2B4	6.22e-05	156	61	4	2cd007b423c2395c5ce331902e7f27c805755eb3
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L6_IT\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	DUSP18 INF2 CCND1 ATP2B4	6.54e-05	158	61	4	9e0589f770920f8ac41cfe5cd0a29e9e7a04a308
ToppCell	tumor_Lymph_Node_/_Brain-Myeloid_cells-pDCs\|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass	SLC12A3 SPTA1 ARHGAP17 BCL11A	6.54e-05	158	61	4	2af7beb48272e5368d9ba6b80f08d47ab8556c08
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L2/3_IT\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	DUSP18 PTPRK PREX1 ATP2B4	7.03e-05	161	61	4	e3327c296d48e821004e61a573abb75624a6f040
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L6_IT-L6_IT_ALM_Oprk1\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	DUSP18 PTPRK CCND1 ATP2B4	7.20e-05	162	61	4	2d28306c6125b31f11ea6d911a167b93a74907c5
ToppCell	Ciliated_cells-B-Cryobiopsy_01\|World / lung cells shred on cell class, cell subclass, sample id	PLCZ1 LGALS9B MUC16 DNAH9	7.55e-05	164	61	4	0e9961acbb1d6c0089e6805ba6756736fa4d8bed
ToppCell	3'_v3-GI_small-bowel-Lymphocytic_B-Memory_B_cells\|GI_small-bowel / Manually curated celltypes from each tissue	SLC12A3 SESN3 BCL11A TOR3A	8.29e-05	168	61	4	8e025bb0541746e232b77ac0e31412ae71420c47
ToppCell	3'_v3-GI_small-bowel-Lymphocytic_B\|GI_small-bowel / Manually curated celltypes from each tissue	SLC12A3 SESN3 BCL11A TOR3A	8.29e-05	168	61	4	5535c1b8b7fde7b59a1bc0580cebdfa963aa1c39
ToppCell	3'-Adult-Distal_Rectal-Epithelial-Tuft-related-BEST4+_epithelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LGALS9C SLC12A3 LGALS9B ZNF582	8.88e-05	171	61	4	317b70d72a4ca5336cfb6a49dc57f8e2a8a1c736
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SLC12A3 KCNJ1 OSBPL3 LRP6	9.29e-05	173	61	4	0c74bdb40e635d906fd180412c23bf7fed61621e
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)-Goblet_(subsegmental)_L.0.4.3.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CLCA2 TNFSF10 CREB3L4 CREB3L1	9.29e-05	173	61	4	e4d9a9a781acc531bc81c3fcee24d637e805c8e1
ToppCell	Adult-Epithelial-lung_goblet_cell-D231\|Adult / Lineage, Cell type, age group and donor	LGALS9C CLCA2 LGALS9B MUC16	9.50e-05	174	61	4	7d2f802f493f19a068e097b2909a9000e2160266
ToppCell	356C-Lymphocytic-NK_cells-NK_cell_A2\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	PLSCR4 SPTA1 SESN3 BCL11A	9.92e-05	176	61	4	052b54c4337ca728974a106b6dbd3b72dd28eb23
ToppCell	COVID-19-lung-B_cells\|lung / Disease (COVID-19 only), tissue and cell type	SESN3 MICAL3 BCL11A ATP2B1	1.01e-04	177	61	4	f54691e5558091c1734ab15153a10bff15ed171e
ToppCell	NS-moderate-d_16-33-Lymphoid-B_cell\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	SESN3 MICAL3 BCL11A ELMO1	1.01e-04	177	61	4	320fd77c7c98e9305dcc34a168ec9d674539ed65
ToppCell	facs-Large_Intestine-Distal-24m-Epithelial-large_intestine_goblet_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	P2RY4 TOR3A CREB3L4 CREB3L1	1.04e-04	178	61	4	07d6d5275a4d17f8024fde74e92ab2505b4adfbf
ToppCell	Adult-Epithelial-lung_goblet_cell\|Adult / Lineage, Cell type, age group and donor	LGALS9C CLCA2 LGALS9B MUC16	1.06e-04	179	61	4	1fc1f252ca943a2f649d1e627f56acbf15f8e058
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Endothelial-blood_vessel_EC-Fetal_arterial_EC\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	IGFBP1 TNFSF10 PREX1 ELMO1	1.11e-04	181	61	4	9bfd93cf053beaee806cacdffd7abef02f94aec6
ToppCell	COVID-19-APC-like-Dendritic_cells\|COVID-19 / group, cell type (main and fine annotations)	SLC12A3 BCL11A PREX1 ELMO1	1.15e-04	183	61	4	703364836b42aa6ac6c68b42b700ac23c4a1afc7
ToppCell	Epithelial-lung_goblet_cell\|World / Lineage, Cell type, age group and donor	CLCA2 LGALS9B TNFSF10 MUC16	1.15e-04	183	61	4	940cbe298e9c53b5622af09264586ed823d3141f
ToppCell	B_cells-ISG-high_B_cells\|World / Immune cells in Kidney/Urine in Lupus Nephritis	PTPRK TNFSF10 MICAL3 BCL11A	1.15e-04	183	61	4	dc2b00e920efa1dcc2a6265cd1024e3249c9974f
ToppCell	COVID-19-APC-like\|COVID-19 / group, cell type (main and fine annotations)	SLC12A3 BCL11A PREX1 ELMO1	1.15e-04	183	61	4	b8f5afaf9ff1b2b1bc60be58654d1b23859dafa9
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage-Monocyte-derived_macrophage-Monocyte-derived_macrophage_L.1.2.5.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	HIF1A ABL2 ATP2B1 PREX1	1.18e-04	184	61	4	d1ea2b60fb1ca1a0b809d131310c43903a9e84ce
ToppCell	3'-GW_trimst-2-LargeIntestine-Endothelial-lymphatic_endothelial-LEC4_(STAB2+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PLSCR4 RAI14 CCND1 ELMO1	1.18e-04	184	61	4	3b0389c3a5a16697de860e98ebc48ed39ede646f
ToppCell	droplet-Mammary_Gland-nan-21m-Endothelial-nan\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DUSP26 CLCA2 PCDHB3 PPARG	1.20e-04	185	61	4	62cfcb0e2a9e6718e6b200dfbb1a81eaead229b5
ToppCell	5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)-Club_(non-nasal)_L.0.4.0.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CLCA2 LGALS9B CCND1 CREB3L1	1.20e-04	185	61	4	5dee5645240637e135677732a35fd416b37367d4
ToppCell	moderate-Lymphoid-B_cell\|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	SESN3 MICAL3 BCL11A ELMO1	1.23e-04	186	61	4	fd2c4c3e8929ca5d64f6c5064e5f3d3d6ba07b5f
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.4.4.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CLCA2 TNFSF10 CCND1 CREB3L4	1.25e-04	187	61	4	82bbc107f58c623f3b90430c90c562624a12abef
ToppCell	NS-moderate-d_07-13-Lymphoid-B_cell\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	SESN3 MICAL3 BCL11A ELMO1	1.28e-04	188	61	4	e9ed34cfea1d93eaa8e63d5b5dbb64f1520d9c4c
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Endothelial-blood_vessel_EC\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	IGFBP1 TNFSF10 PREX1 ELMO1	1.31e-04	189	61	4	9e58411e51019ca59e78d3e737d65d2bcbbea2be
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	XYLT1 PTPRK BCL11A ATP2B1	1.31e-04	189	61	4	a75226616340045b581d08429d2e123e041dee55
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SLC12A3 KCNJ1 OSBPL3 ATP2B4	1.31e-04	189	61	4	e32172ad09e93f6ac6ea2b92145b2b73003f7970
ToppCell	CTRL-Lymphoid-B_cell\|Lymphoid / Disease state, Lineage and Cell class	SESN3 MICAL3 BCL11A ELMO1	1.31e-04	189	61	4	14f3a8c0f4f057ad4e6839b4c3eeaf956d6dc92e
ToppCell	Healthy_donor-B_memory\|Healthy_donor / disease group, cell group and cell class (v2)	MUC16 MICAL3 BCL11A TOR3A	1.33e-04	190	61	4	46104a521f00d399315deca86699cb261b2795d6
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_B-B_cell-B_c01-TCL1A\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	PTPRK BCL11A TOR3A ATP2B1	1.33e-04	190	61	4	60bb6aaea9691d07295f61c14d1650f5041a0f9c
ToppCell	COVID_vent-Lymphocytic-B_cell\|COVID_vent / Disease condition, Lineage, Cell class and subclass	PTPRK ARHGAP17 MICAL3 BCL11A	1.33e-04	190	61	4	40b5e9e8f8fd8d84cb5b43e67b49267082348e9f
ToppCell	COVID_vent-Lymphocytic-B_cell-\|COVID_vent / Disease condition, Lineage, Cell class and subclass	PTPRK ARHGAP17 MICAL3 BCL11A	1.33e-04	190	61	4	a37a32dc1b931562a6660074e19d5598efc65284
ToppCell	IPF-Epithelial-Goblet\|IPF / Disease state, Lineage and Cell class	CLCA2 PTPRK RAI14 CCND1	1.33e-04	190	61	4	e41dd5a997ad9952810ffecb57737c03ea1d88b3
ToppCell	IPF-Epithelial-Goblet\|World / Disease state, Lineage and Cell class	CLCA2 PTPRK RAI14 CCND1	1.33e-04	190	61	4	c29dabf0826663b9d6df51a7af9b76592090e44c
ToppCell	Dendritic_Cells-Myositis-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	XYLT1 SLC12A3 PREX1 ELMO1	1.36e-04	191	61	4	b51c8ff1279581088557bb36760c70209c77148c
ToppCell	NS-critical-d_16-33-Epithelial-Secretory-diff\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	TNFSF10 MUC16 CCND1 CREB3L1	1.39e-04	192	61	4	02b11233b4da2d85b96498b3c6e22e3a31b3d049
ToppCell	COPD-Epithelial-Goblet\|COPD / Disease state, Lineage and Cell class	PTPRK MUC16 RAI14 CCND1	1.39e-04	192	61	4	93b2ca0a97776d28c7e8f1a0642c4b63a5554aab
ToppCell	moderate-Lymphoid-B_cell\|Lymphoid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	SESN3 MICAL3 BCL11A ATP2B1	1.39e-04	192	61	4	ae3727503c3b9f4695e565fd3161cc33b898f349
ToppCell	3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TNFSF10 MUC16 CREB3L4 CREB3L1	1.41e-04	193	61	4	605fc2a25ed6846fb283b2918cfed98df6039d6b
ToppCell	Club_cells-Myositis-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	CLCA2 TNFSF10 MUC16 CCND1	1.41e-04	193	61	4	6582c0367052b9d10fb629c383ee0c55872afd2d
ToppCell	droplet-Mammary_Gland-nan-21m-Epithelial-luminal_epithelial_cell_of_mammary_gland\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DUSP18 CLCA2 OSBPL3 CCND1	1.41e-04	193	61	4	22ebc3f586eb0aabc5785e468c88d7416c624ff4
ToppCell	Smart-seq2-lymph_node_(Smart-seq2)-lymphocytic-B_lymphocytic-B_cell\|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	ARHGAP17 MICAL3 BCL11A ATP2B1	1.44e-04	194	61	4	ff661419b697aef51a53fdeac8d37d870d65f491
ToppCell	droplet-Mammary_Gland-nan-21m-Epithelial-luminal_progenitor_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DUSP18 CLCA2 OSBPL3 CCND1	1.44e-04	194	61	4	0ef63abcfd057079a9a6f8b27404ff521d44845d
ToppCell	control-Lymphoid-B_cell\|Lymphoid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	SESN3 MICAL3 BCL11A ELMO1	1.44e-04	194	61	4	a5284adca931a78b1c4592925c4860853ebd24f1
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.4.4.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CLCA2 TNFSF10 CREB3L4 CREB3L1	1.44e-04	194	61	4	40251e6415a62fa55d86f2e8609bf0402e1c1abb
ToppCell	IPF-Endothelial-VE_Capillary_A\|Endothelial / Disease state, Lineage and Cell class	TNFSF10 CCND1 PREX1 ATP2B4	1.44e-04	194	61	4	777ce41c3f22c591e2d81120f189b834e53ffb4b
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B-B_cell-B_c02-MS4A1-CD27\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	MICAL3 BCL11A TOR3A ATP2B1	1.44e-04	194	61	4	d852aebf7a763b9a776c4570711f0c759f591910
ToppCell	15-Trachea-Epithelial-Basal_cell\|Trachea / Age, Tissue, Lineage and Cell class	CLCA2 TNFSF10 CCND1 BCL11A	1.44e-04	194	61	4	67edcbb9ed1a01dd06b6f17621c54aa58df74c69
ToppCell	Bronchial-NucSeq-Immune_Lymphocytic-B-B_cell-B_mature\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	MICAL3 BCL11A ATP2B1 ELMO1	1.47e-04	195	61	4	3311a1bf4ed94820b45047d44fc14b14ac72e6fb
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B-B_cell\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	MICAL3 BCL11A TOR3A ATP2B1	1.47e-04	195	61	4	481989d2e5bd2582da3d86b0155c4d6615317067
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	MICAL3 BCL11A TOR3A ATP2B1	1.47e-04	195	61	4	6108a27523d1b93a7fbe35cb95704a5ad9071e3c
ToppCell	Tracheal-NucSeq-Epithelial-Epi_airway_secretory\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	LGALS9B TNFSF10 MUC16 RAI14	1.50e-04	196	61	4	b07db4a53ab9be9aad6fae5e45f9547db829d096
ToppCell	3'-Distal_airway-Epithelial-Epithelial_transtional-secretory\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CLCA2 TNFSF10 CREB3L4 CREB3L1	1.50e-04	196	61	4	8e909c31733762646359fe78b645cbd60237459e
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Epithelial-Epithelial,_Airway-ciliated_cell\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	PTPRK MUC16 RAI14 CCND1	1.50e-04	196	61	4	b246e482f012dd9782b49c2a953acedfa3c1139d
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Epithelial-Epithelial,_Airway-ciliated_cell-Epi-Ciliated\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	PTPRK MUC16 RAI14 CCND1	1.50e-04	196	61	4	808c0a7d1889a8f3508ed9790c6dc7ec16bbc840
ToppCell	critical-Epithelial-Secretory\|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	PTPRK RAI14 CCND1 CREB3L1	1.50e-04	196	61	4	7da687eb983a54c28ee990424cc52e01caf5f4aa
ToppCell	Tracheal-NucSeq-Epithelial-Epi_airway_secretory-Secretory_Goblet\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	LGALS9B TNFSF10 MUC16 RAI14	1.50e-04	196	61	4	c366f980cc04abfe1c0c14746c11810c812a42c0
ToppCell	Children_(3_yrs)-Immune\|Children_(3_yrs) / Lineage, Cell type, age group and donor	PPARG ATP2B1 PREX1 ELMO1	1.53e-04	197	61	4	f18807124b91310fcd84238484a80ecdba684679
ToppCell	Bronchial-NucSeq-Immune_Lymphocytic-B-B_cell\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	MICAL3 BCL11A ATP2B1 ELMO1	1.53e-04	197	61	4	da61afba697ec49ca86e062d35a825280da558ac
ToppCell	Bronchial-NucSeq-Immune_Lymphocytic-B\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DUSP26 MICAL3 BCL11A ELMO1	1.53e-04	197	61	4	0f489d26e4013d1b5a90559856ed2de32a0bb772
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	XYLT1 BCL11A PREX1 ELMO1	1.53e-04	197	61	4	61ef3f417767c3f5296a26399da63e3e4f58faf8
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.1.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CLCA2 TNFSF10 MUC16 CCND1	1.56e-04	198	61	4	9718f4c013c347f1b3c785ae232dd2fb6c1fe298
ToppCell	Bronchial_Brush-Epithelial-Club\|Bronchial_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X	CLCA2 TNFSF10 RAI14 CREB3L1	1.56e-04	198	61	4	61292a2b5aacb6080a679a31b70a211bdec59a3b
ToppCell	Tracheal-NucSeq-Immune_Lymphocytic-B-B_cell\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	OSBPL3 MICAL3 ATP2B1 PREX1	1.56e-04	198	61	4	824461cf44098440ba8bc0df96735423ac65bda1
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_airway_secretory-Secretory_Goblet\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	LGALS9C LGALS9B MUC16 CREB3L4	1.56e-04	198	61	4	af07a970afaa435c6433bb5c1cbff4c67af350c7
ToppCell	Adult-Immune\|Adult / Lineage, Cell type, age group and donor	PPARG ATP2B1 PREX1 ELMO1	1.56e-04	198	61	4	9bfd7b88aa646eaf5eddb15cf985c7ca910cb35e
ToppCell	COVID-19-Epithelial-AT2,_AT1_cells\|COVID-19 / Condition, Lineage and Cell class	PTPRK LRP6 RAI14 CREB3L1	1.56e-04	198	61	4	7e6f089e71e70190ff8486341ab06719d7741467
ToppCell	Parenchymal-10x3prime_v2-Epithelial-Epi_airway_secretory-Secretory_Goblet\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	LGALS9C CLCA2 MUC16 BCL11A	1.56e-04	198	61	4	5dd2aa7684c36beffa204ca4c04d0501cabac10f
ToppCell	NS-critical-LOC-Epithelial-Secretory_LYPD2\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	TNFSF10 MUC16 RAI14 CREB3L1	1.56e-04	198	61	4	4a481e1edb80b950c823ed926842cd5132cfb27f
ToppCell	Bronchial_Biopsy\|World / Tissue, Lineage and Cell class of Lung Cells from 10X	CLCA2 SESN3 CCND1 BCL11A	1.56e-04	198	61	4	f5b7013045b61fc56894f80092f799770dde1c8f
ToppCell	NS-moderate-d_07-13-Epithelial-Secretory-diff\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	TNFSF10 MUC16 CCND1 CREB3L1	1.56e-04	198	61	4	361f3062f73a0add16dd6fbe927698416515879f
Drug	AC1Q6S3U	HIF1A GBF1 P2RY4 TNFSF10 CCND1 UCK1 PPARG	2.01e-07	159	60	7	CID000000689
Drug	gingerol	HIF1A TNFSF10 LRP6 CCND1 PPARG	1.14e-06	70	60	5	ctd:C007845
Drug	caloxin 1b1	ATP2B1 ATP2B4	6.83e-06	2	60	2	ctd:C510327
Drug	AC1NSKPI	P2RY4 KCNJ1 ATP2B1 ATP2B4	1.55e-05	57	60	4	CID005311482
Drug	canola oil	IGFBP1 TNFSF10 CCND1 PPARG PREX1	1.76e-05	122	60	5	ctd:C061996
Drug	8-iso-prostaglandin E2	PLCZ1 HIF1A GBF1 IGFBP1 SLC12A3 CLK1 KCNJ1 CCND1 PPARG	2.68e-05	603	60	9	CID000000158
Disease	Hypertensive disease	HIF1A SLC12A3 KCNJ1 PPARG ATP2B1	2.35e-05	190	53	5	C0020538
Disease	birth weight, parental genotype effect measurement	CCND1 INO80 DCST2 PREX1 CREB3L1	2.47e-05	192	53	5	EFO_0004344, EFO_0005939
Disease	Thyroid Gland Follicular Adenoma	HIF1A CCND1 PPARG	3.44e-05	35	53	3	C0151468
Disease	Thyroid Neoplasm	HIF1A CCND1 PPARG	4.07e-05	37	53	3	C0040136
Disease	Hailey-Hailey disease (implicated_via_orthology)	ATP2B1 ATP2B4	4.73e-05	6	53	2	DOID:0050429 (implicated_via_orthology)
Disease	Thyroid carcinoma	HIF1A CCND1 PPARG	6.88e-05	44	53	3	C0549473
Disease	Colonic Neoplasms	IGFBP1 TNFSF10 CCND1 PPARG	1.63e-04	152	53	4	C0009375
Disease	glomerulosclerosis (implicated_via_orthology)	INF2 PPARG	1.72e-04	11	53	2	DOID:0050851 (implicated_via_orthology)
Disease	Malignant tumor of colon	IGFBP1 TNFSF10 CCND1 PPARG	1.94e-04	159	53	4	C0007102
Disease	Neoplasms, Experimental	HIF1A TNFSF10 CCND1	2.31e-04	66	53	3	C0027659
Disease	Giant Cell Glioblastoma	HIF1A TNFSF10 PPARG	4.70e-04	84	53	3	C0334588
Disease	Malignant neoplasm of breast	HIF1A CLCA2 TNFSF10 KCNJ1 CCND1 BCL11A PKDREJ DNAH9	6.21e-04	1074	53	8	C0006142
Disease	Kidney Failure	INF2 PPARG	7.15e-04	22	53	2	C0035078
Disease	Renal glomerular disease	SLC12A3 INF2	7.82e-04	23	53	2	C0268731
Disease	Glomerulopathy Assessment	SLC12A3 INF2	7.82e-04	23	53	2	C4521256
Disease	Pancreatic Neoplasm	HIF1A TNFSF10 PPARG	7.82e-04	100	53	3	C0030297
Disease	Prostatic Neoplasms	HIF1A PTPRK TNFSF10 SESN3 CCND1 CREB3L4	8.06e-04	616	53	6	C0033578
Disease	Malignant neoplasm of prostate	HIF1A PTPRK TNFSF10 SESN3 CCND1 CREB3L4	8.06e-04	616	53	6	C0376358
Disease	Malignant neoplasm of pancreas	HIF1A TNFSF10 PPARG	8.29e-04	102	53	3	C0346647
Disease	acute kidney failure (implicated_via_orthology)	HIF1A PPARG	1.08e-03	27	53	2	DOID:3021 (implicated_via_orthology)
Disease	Hyperplasia	HIF1A CCND1	1.16e-03	28	53	2	C0020507
Disease	Antihypertensive use measurement	INO80 ATP2B1 PREX1 ATP2B4	1.32e-03	265	53	4	EFO_0009927

Protein segments in the cluster

Peptide	Gene	Start	Entry
FPEHLDHFTENMEDF	CREB3L1	36	Q96BA8
ETCNDFHPMFFTHDR	ELMO1	436	Q92556
FHPMFFTHDRSFEEF	ELMO1	441	Q92556
SFAETHQAFETMFHD	ABL2	531	P42684
HQAFETMFHDSSISE	ABL2	536	P42684
MEQEHFSEFLRSHHF	AKAP10	351	O43572
MSDATFEESSEHFPH	AFTPH	456	Q6ULP2
NLAAMTPHDFIEHFL	CCND1	151	P24385
IHNFMTHPEFRIEDS	ATP2B1	1141	P20020
KSIHSFMTHPEFAIE	ATP2B4	1161	P23634
FTVFPTHDSKEHLAM	CLK1	376	P49759
VSPESMDNYSHFHEL	RAI14	511	Q9P0K7
HFIMPTLFDSHEEFN	INO80	696	Q9ULG1
TFHAFAETMDIPSTH	MUC16	366	Q8WXI7
HETMNPAHVLFDRFV	MICAL3	6	Q7RTP6
ARIQAATMSDFHVHP	IGDCC3	131	Q8IVU1
FCIDSSHPHALDFMN	KCTD21	236	Q4G0X4
SVFDFTHPCDHEEMR	HIF1A	131	Q16665
SGSHIAFHMNPRFDE	LGALS9C	261	Q6DKI2
SGSHIAFHMNPRFDE	LGALS9B	261	Q3B8N2
EMALATHHPSAFDRV	BCL11A	286	Q9H165
MADADHFDIHFPLDL	PLSCR4	286	Q9NRQ2
DNFHLMAPSEEDHSI	IGFBP1	136	P08833
IHSDIFSPMDIHAFS	LRP6	261	O75581
VDMSSHQEVFASLFH	INF2	266	Q27J81
PEEFDHYVHFSSAVM	P2RY4	191	P51582
AVSPHFDDMHSNTAS	CKAP5	1526	Q14008
PDMFFVHSKRSFIHD	GABRR1	156	P24046
DPFAHVAALHFDQMF	FIG4	351	Q92562
MSSQAFPAEEDHHNE	CPHXL2	1	A0A1W2PPK0
HSDSASVHDMDYVNP	GBF1	366	Q92538
RPHFVNTVEMFDLEH	KLHDC8B	241	Q8IXV7
FEFNMTATHHFSVDL	DCST2	281	Q5T1A1
EEHSENSHPEFRVFM	DNAH9	3976	Q9NYC9
DSCMVSELPFDAHAH	CREB3L4	151	Q8TEY5
EIAMFPHEVNHFFSG	OSBPL3	151	Q9H4L5
LHAEDPLSITFMDQH	PTPRK	811	Q15262
VNDHSPVFFENEMHL	PCDHB3	126	Q9Y5E6
TETFDFVHNVMSIPH	MTERF3	331	Q96E29
MLAHLQSFSSVPEHF	SZT2	506	Q5T011
YSPLLSHMSSEDEHF	PLAC8L1	21	A1L4L8
EPHRSIFPEMHSDSA	ARHGAP17	846	Q68EM7
DMTHPLNDYFISSSH	PLCZ1	156	Q86YW0
DFIPFHAVSQVDHIM	PKDREJ	2036	Q9NTG1
SVMEDHSHSFDIKPF	PPARG	51	P37231
EETKHFPMNHSLQEF	PREX1	1246	Q8TCU6
VEAHDSPAFDMSIHF	DUSP26	116	Q9BV47
MSIHFQTAADFIHRA	DUSP26	126	Q9BV47
DSADFHHSFPMNGTE	CLCA2	281	Q9UQC9
FFHTVLENSPHCDTM	XYLT1	531	Q86Y38
EHFPDLFHVMSHKEV	ZNF865	676	P0CJ78
FDHPDAFDNDLMHRT	UCK1	86	Q9HA47
AFSHDHPTDVDYRVM	PES1	206	O00541
FHSFPHSDFEDDMII	SESN3	306	P58005
HDVDPEISHVNFRMF	ZSCAN5A	36	Q9BUG6
DLNMFTFHVDSEHPN	ZHX1	81	Q9UKY1
HALAFDSRPSHEMTD	SLC12A3	101	P55017
HQEHRADMEAEAPTF	SPTA1	1331	P02549
HEEMPTFDQHASLTF	ZNF582	146	Q96NG8
SDCVRMFIATFHFPH	TOR3A	191	Q9H497
TNEHLIDMDHEASFF	TNFSF10	261	P50591
HDSDPETCHVNFRMF	ZSCAN5C	36	A6NGD5
DFFDPIADHIHSVEM	DUSP18	81	Q8NEJ0
VIDHNSPFFHMAAET	KCNJ1	271	P48048