Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionDNA-binding transcription factor activity, RNA polymerase II-specific

PRDM15 ZNF75D ZNF208 ZNF140 ZBTB21 ZNF254 RREB1

2.06e-041412197GO:0000981
GeneOntologyMolecularFunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding

PRDM15 ZNF75D ZNF208 ZNF140 ZNF254 RREB1

7.75e-041244196GO:0000978
GeneOntologyMolecularFunctioncis-regulatory region sequence-specific DNA binding

PRDM15 ZNF75D ZNF208 ZNF140 ZNF254 RREB1

8.68e-041271196GO:0000987
GeneOntologyMolecularFunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding

PRDM15 ZNF75D ZNF208 ZNF140 ZNF254 RREB1

1.78e-031459196GO:0000977
GeneOntologyMolecularFunctionorganic cation transmembrane transporter activity

SLC22A16 SERINC5

2.79e-0383192GO:0015101
GeneOntologyMolecularFunctionDNA-binding transcription repressor activity, RNA polymerase II-specific

ZNF208 ZNF140 ZBTB21

3.27e-03320193GO:0001227
GeneOntologyMolecularFunctionDNA-binding transcription repressor activity

ZNF208 ZNF140 ZBTB21

3.44e-03326193GO:0001217
GeneOntologyMolecularFunctionATP-dependent activity, acting on DNA

ERCC6L2 HELQ

6.39e-03127192GO:0008094
GeneOntologyMolecularFunctionzinc ion binding

ZNF75D ZNF208 TRIM67 ZMYND8

8.92e-03891194GO:0008270
GeneOntologyMolecularFunctionhelicase activity

ERCC6L2 HELQ

9.74e-03158192GO:0004386
GeneOntologyCellularComponentsite of DNA damage

HELQ ZMYND8

6.09e-03137182GO:0090734
Domain-

PRDM15 ZNF75D ZNF208 ZNF140 ZBTB21 ZNF254 RREB1

2.80e-066791973.30.160.60
Domainzf-C2H2

PRDM15 ZNF75D ZNF208 ZNF140 ZBTB21 ZNF254 RREB1

3.20e-06693197PF00096
DomainZnf_C2H2/integrase_DNA-bd

PRDM15 ZNF75D ZNF208 ZNF140 ZBTB21 ZNF254 RREB1

3.24e-06694197IPR013087
DomainZINC_FINGER_C2H2_2

PRDM15 ZNF75D ZNF208 ZNF140 ZBTB21 ZNF254 RREB1

6.71e-06775197PS50157
DomainZINC_FINGER_C2H2_1

PRDM15 ZNF75D ZNF208 ZNF140 ZBTB21 ZNF254 RREB1

6.82e-06777197PS00028
DomainZnf_C2H2-like

PRDM15 ZNF75D ZNF208 ZNF140 ZBTB21 ZNF254 RREB1

8.00e-06796197IPR015880
DomainZnf_C2H2

PRDM15 ZNF75D ZNF208 ZNF140 ZBTB21 ZNF254 RREB1

8.61e-06805197IPR007087
DomainZnF_C2H2

PRDM15 ZNF75D ZNF208 ZNF140 ZBTB21 ZNF254 RREB1

8.82e-06808197SM00355
DomainKRAB

ZNF75D ZNF208 ZNF140 ZNF254

4.10e-04358194PS50805
DomainKRAB

ZNF75D ZNF208 ZNF140 ZNF254

4.10e-04358194PF01352
DomainKRAB

ZNF75D ZNF208 ZNF140 ZNF254

4.59e-04369194SM00349
DomainKRAB

ZNF75D ZNF208 ZNF140 ZNF254

4.64e-04370194IPR001909
Domain4_helix_cytokine-like_core

ZNF254 RREB1

2.54e-0374192IPR009079
Domainzf-C2H2_6

ZNF208 ZNF140 RREB1

3.74e-03314193PF13912
DomainHelicase_C

ERCC6L2 HELQ

5.22e-03107192PF00271
DomainHELICc

ERCC6L2 HELQ

5.22e-03107192SM00490
DomainHelicase_C

ERCC6L2 HELQ

5.31e-03108192IPR001650
DomainHELICASE_CTER

ERCC6L2 HELQ

5.41e-03109192PS51194
DomainHELICASE_ATP_BIND_1

ERCC6L2 HELQ

5.41e-03109192PS51192
DomainDEXDc

ERCC6L2 HELQ

5.41e-03109192SM00487
DomainHelicase_ATP-bd

ERCC6L2 HELQ

5.51e-03110192IPR014001
Pubmed

Ts65Dn -- localization of the translocation breakpoint and trisomic gene content in a mouse model for Down syndrome.

PRDM15 ZBTB21

5.93e-06719211528125
Pubmed

Expansion and diversification of KRAB zinc-finger genes within a cluster including Regulator of sex-limitation 1 and 2.

ZNF208 ZNF254

2.96e-051519215885501
Pubmed

Evolutionary breakpoints on human chromosome 21.

PRDM15 ZBTB21

5.34e-052019211707078
Pubmed

Genetic association with overall survival of taxane-treated lung cancer patients - a genome-wide association study in human lymphoblastoid cell lines followed by a clinical association study.

PRDM15 ZNF254

1.06e-042819223006423
Pubmed

Regulator of sex-limitation (Rsl) encodes a pair of KRAB zinc-finger genes that control sexually dimorphic liver gene expression.

ZNF208 ZNF254

1.14e-042919214563677
Cytoband19p12

ZNF208 ZNF254

6.36e-049019219p12
CytobandEnsembl 112 genes in cytogenetic band chr19p12

ZNF208 ZNF254

1.16e-03122192chr19p12
Cytoband21q22.3

PRDM15 ZBTB21

1.28e-0312819221q22.3
CytobandEnsembl 112 genes in cytogenetic band chr5q14

CCNH SERINC5

1.44e-03136192chr5q14
CytobandEnsembl 112 genes in cytogenetic band chr21q22

PRDM15 ZBTB21

1.05e-02377192chr21q22
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

PRDM15 ZNF75D ZNF208 ZNF140 ZBTB21 ZNF254 RREB1

7.37e-0771815728
Diseasefactor VII activating protease measurement

ZMYND8 RREB1

4.56e-0455172EFO_0009368
Diseasemethylcobalamin deficiency type cblE

PRDM15 ZNF254

8.24e-0474172MONDO_0009354
Diseaseinsomnia measurement

PRDM15 ZMYND8 RREB1

1.95e-03443173EFO_0007876
Diseasemelanoma

SLC22A16 EYS

2.36e-03126172EFO_0000756
Diseasepeak expiratory flow

ERCC6L2 EYS RREB1

2.72e-03498173EFO_0009718
Diseasecoffee consumption measurement

EYS ZMYND8

4.84e-03182172EFO_0006781
Diseasechronic obstructive pulmonary disease

ERCC6L2 PRDM15 RREB1

6.72e-03688173EFO_0000341
Diseaseceramide measurement

PRDM15 EYS

7.94e-03235172EFO_0010222
Diseaseobesity

SERINC5 ZNF254

8.33e-03241172EFO_0001073

Protein segments in the cluster

PeptideGeneStartEntry
SQHRRHQSWSTFKSM

ADGRB2

1536

O60241
MYHNSSQKRHWTFSS

CCNH

1

P51946
AHFHMKQRSSWDSQQ

ARHGAP39

566

Q9C0H5
SSKSHYSHKSRHMWS

PSKH2

356

Q96QS6
SWMSFASFHVRKKTH

EYS

2726

Q5T1H1
LHFSSRMHATFSAAW

IL17RE

376

Q8NFR9
SSKAENHMSRWAAHD

ERCC6L2

1141

Q5T890
HSMKERDWKSSSHNT

HELQ

216

Q8TDG4
SSSKFQTSSQKWHMQ

ZMYND8

821

Q9ULU4
MKSRTWASVHLHSFF

SLC22A16

236

Q86VW1
VWNQHSRSASMHTFL

PRDM15

266

P57071
RSWFMHCNSHTNRTE

TRIM67

696

Q6ZTA4
RLWSHFQSHMSQASE

ZBTB21

951

Q9ULJ3
FWSLQDLTRHMRSHT

RREB1

1521

Q92766
MTVTNWFNHVRSAFH

SERINC5

406

Q86VE9
RFRWSSDLNKHFMTH

ZNF75D

401

P51815
FNWSSNLMEHKRIHT

ZNF208

506

O43345
SFSWSSNLAKHQRTH

ZNF140

421

P52738
FIWSSTLTRHKRMHT

ZNF254

331

O75437
FIWSSTLTRHKRMHT

ZNF254

471

O75437