Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	nuclear receptor activity	NR2C2 NR2F6 NR2E3 RORB RORC NR3C1 HNF4A HNF4G NR2F1 PGR	1.06e-15	60	57	10	GO:0004879
GeneOntologyMolecularFunction	ligand-activated transcription factor activity	NR2C2 NR2F6 NR2E3 RORB RORC NR3C1 HNF4A HNF4G NR2F1 PGR	1.26e-15	61	57	10	GO:0098531
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	ZBTB49 NR2C2 ZBTB46 NR2F6 NR2E3 ZNF577 INSM1 ZNF814 ZNF480 RORB RORC NR3C1 HNF4A HNF4G NR2F1 PGR	1.30e-06	1412	57	16	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ZBTB49 NR2C2 NR2F6 NR2E3 ZNF577 INSM1 ZNF814 ZNF480 RORB RORC NR3C1 HNF4A HNF4G NR2F1 PGR	1.40e-06	1244	57	15	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	ZBTB49 NR2C2 NR2F6 NR2E3 ZNF577 INSM1 ZNF814 ZNF480 RORB RORC NR3C1 HNF4A HNF4G NR2F1 PGR	1.83e-06	1271	57	15	GO:0000987
GeneOntologyMolecularFunction	zinc ion binding	NR2C2 NR2F6 NR2E3 POLR1A ENPP1 RORB RORC NR3C1 HNF4A HNF4G NR2F1 PGR	6.40e-06	891	57	12	GO:0008270
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ZBTB49 NR2C2 NR2F6 NR2E3 ZNF577 INSM1 ZNF814 ZNF480 RORB RORC NR3C1 HNF4A HNF4G NR2F1 PGR	9.91e-06	1459	57	15	GO:0000977
GeneOntologyMolecularFunction	transition metal ion binding	ARG2 NR2C2 NR2F6 NR2E3 POLR1A ENPP1 RORB RORC NR3C1 HNF4A HNF4G NR2F1 PGR	2.32e-05	1189	57	13	GO:0046914
GeneOntologyMolecularFunction	DNA-binding transcription repressor activity, RNA polymerase II-specific	ZBTB49 ZBTB46 NR2F6 INSM1 RORC NR3C1 NR2F1	3.38e-05	320	57	7	GO:0001227
GeneOntologyMolecularFunction	DNA-binding transcription repressor activity	ZBTB49 ZBTB46 NR2F6 INSM1 RORC NR3C1 NR2F1	3.81e-05	326	57	7	GO:0001217
GeneOntologyMolecularFunction	nuclear steroid receptor activity	NR2E3 NR3C1 PGR	4.85e-05	25	57	3	GO:0003707
GeneOntologyMolecularFunction	DNA-binding transcription activator activity, RNA polymerase II-specific	NR2C2 NR2E3 ZNF814 RORB NR3C1 HNF4A HNF4G PGR	1.79e-04	560	57	8	GO:0001228
GeneOntologyMolecularFunction	DNA-binding transcription activator activity	NR2C2 NR2E3 ZNF814 RORB NR3C1 HNF4A HNF4G PGR	1.93e-04	566	57	8	GO:0001216
GeneOntologyMolecularFunction	calcium ion binding	SNED1 HSPG2 FAT1 STAB2 CELSR2 DSPP ENPP1 MATN3 ASTN2	2.51e-04	749	57	9	GO:0005509
GeneOntologyMolecularFunction	estrogen response element binding	NR3C1 PGR	4.33e-04	11	57	2	GO:0034056
GeneOntologyMolecularFunction	transcription coactivator binding	ZBTB49 RORC PGR	4.93e-04	54	57	3	GO:0001223
GeneOntologyMolecularFunction	transcription coregulator binding	ZBTB49 RORC HNF4A PGR	6.85e-04	140	57	4	GO:0001221
GeneOntologyMolecularFunction	collagen binding	HSPG2 DSPP ITGA9	1.61e-03	81	57	3	GO:0005518
GeneOntologyMolecularFunction	importin-alpha family protein binding	GOLGA8B GOLGA8A	1.62e-03	21	57	2	GO:0061676
GeneOntologyMolecularFunction	extracellular matrix structural constituent	HSPG2 DSPP MATN3 LAMA3	2.04e-03	188	57	4	GO:0005201
GeneOntologyMolecularFunction	scavenger receptor activity	STAB2 ENPP1	2.68e-03	27	57	2	GO:0005044
GeneOntologyBiologicalProcess	intracellular receptor signaling pathway	USP50 NR2C2 NR2F6 NR2E3 RORB RORC NR3C1 HNF4A HNF4G NR2F1 PGR	1.58e-08	416	57	11	GO:0030522
GeneOntologyBiologicalProcess	neuron development	HSPG2 NR2F6 NR2E3 CELSR2 SZT2 ENPP1 INSM1 LAMA3 GOLGA8B RORB RERE NR3C1 CTNND2 GOLGA8A NR2F1	6.94e-06	1463	57	15	GO:0048666
GeneOntologyBiologicalProcess	negative regulation of DNA-templated transcription	ZBTB49 NR2C2 ZBTB46 NR2F6 NR2E3 INSM1 RORB RORC RERE NR3C1 HNF4A LANCL2 NR2F1	8.95e-05	1399	57	13	GO:0045892
GeneOntologyBiologicalProcess	negative regulation of RNA biosynthetic process	ZBTB49 NR2C2 ZBTB46 NR2F6 NR2E3 INSM1 RORB RORC RERE NR3C1 HNF4A LANCL2 NR2F1	9.90e-05	1413	57	13	GO:1902679
MousePheno	increased alveolar macrophage number	LAMA3 GOLGA8B GOLGA8A	1.11e-05	14	45	3	MP:0014228
MousePheno	abnormal alveolar macrophage number	LAMA3 GOLGA8B GOLGA8A	1.38e-05	15	45	3	MP:0014227
MousePheno	abnormal chondrocyte proliferation	HSPG2 ENPP1 MATN3	3.42e-05	20	45	3	MP:0014099
MousePheno	osteoarthritis	HSPG2 ENPP1 MATN3	3.98e-05	21	45	3	MP:0003560
MousePheno	abnormal alveolar macrophage morphology	LAMA3 GOLGA8B GOLGA8A	8.64e-05	27	45	3	MP:0008245
Domain	Znf_NHR/GATA	NR2C2 NR2F6 NR2E3 RORB RORC RERE NR3C1 HNF4A HNF4G NR2F1 PGR	1.57e-17	58	57	11	IPR013088
Domain	zf-C4	NR2C2 NR2F6 NR2E3 RORB RORC NR3C1 HNF4A HNF4G NR2F1 PGR	1.14e-16	46	57	10	PF00105
Domain	Znf_hrmn_rcpt	NR2C2 NR2F6 NR2E3 RORB RORC NR3C1 HNF4A HNF4G NR2F1 PGR	1.14e-16	46	57	10	IPR001628
Domain	Nuclear_hrmn_rcpt	NR2C2 NR2F6 NR2E3 RORB RORC NR3C1 HNF4A HNF4G NR2F1 PGR	1.14e-16	46	57	10	IPR001723
Domain	NUCLEAR_REC_DBD_2	NR2C2 NR2F6 NR2E3 RORB RORC NR3C1 HNF4A HNF4G NR2F1 PGR	1.14e-16	46	57	10	PS51030
Domain	NUCLEAR_REC_DBD_1	NR2C2 NR2F6 NR2E3 RORB RORC NR3C1 HNF4A HNF4G NR2F1 PGR	1.14e-16	46	57	10	PS00031
Domain	ZnF_C4	NR2C2 NR2F6 NR2E3 RORB RORC NR3C1 HNF4A HNF4G NR2F1 PGR	1.14e-16	46	57	10	SM00399
Domain	HOLI	NR2C2 NR2F6 NR2E3 RORB RORC NR3C1 HNF4A HNF4G NR2F1 PGR	1.82e-16	48	57	10	SM00430
Domain	Nucl_hrmn_rcpt_lig-bd	NR2C2 NR2F6 NR2E3 RORB RORC NR3C1 HNF4A HNF4G NR2F1 PGR	1.82e-16	48	57	10	IPR000536
Domain	Hormone_recep	NR2C2 NR2F6 NR2E3 RORB RORC NR3C1 HNF4A HNF4G NR2F1 PGR	1.82e-16	48	57	10	PF00104
Domain	-	NR2C2 NR2F6 NR2E3 RORC RERE NR3C1 HNF4A HNF4G NR2F1 PGR	1.18e-15	57	57	10	3.30.50.10
Domain	-	NR2C2 NR2F6 NR2E3 RORC NR3C1 HNF4A HNF4G NR2F1 PGR	1.48e-14	47	57	9	1.10.565.10
Domain	COUP_TF	NR2F6 HNF4A HNF4G NR2F1	3.89e-10	5	57	4	IPR003068
Domain	EGF_2	SNED1 HSPG2 FAT1 STAB2 CELSR2 NRXN2 MATN3 LAMA3 ASTN2	1.01e-07	265	57	9	PS01186
Domain	LAM_G_DOMAIN	HSPG2 FAT1 CELSR2 NRXN2 LAMA3	1.03e-07	38	57	5	PS50025
Domain	EGF	SNED1 HSPG2 FAT1 STAB2 CELSR2 NRXN2 MATN3	1.07e-07	126	57	7	PF00008
Domain	Laminin_G_2	HSPG2 FAT1 CELSR2 NRXN2 LAMA3	1.34e-07	40	57	5	PF02210
Domain	LamG	HSPG2 FAT1 CELSR2 NRXN2 LAMA3	2.19e-07	44	57	5	SM00282
Domain	EGF_3	SNED1 HSPG2 FAT1 STAB2 CELSR2 NRXN2 MATN3 ASTN2	5.42e-07	235	57	8	PS50026
Domain	EGF	SNED1 HSPG2 FAT1 STAB2 CELSR2 NRXN2 MATN3 LAMA3	5.42e-07	235	57	8	SM00181
Domain	EGF-like_dom	SNED1 HSPG2 FAT1 STAB2 CELSR2 NRXN2 MATN3 LAMA3	8.39e-07	249	57	8	IPR000742
Domain	Laminin_G	HSPG2 FAT1 CELSR2 NRXN2 LAMA3	8.96e-07	58	57	5	IPR001791
Domain	EGF_1	SNED1 HSPG2 FAT1 STAB2 CELSR2 NRXN2 LAMA3 ASTN2	1.00e-06	255	57	8	PS00022
Domain	EGF-like_CS	SNED1 HSPG2 FAT1 STAB2 CELSR2 NRXN2 MATN3 LAMA3	1.19e-06	261	57	8	IPR013032
Domain	EGF_CA	SNED1 HSPG2 FAT1 STAB2 CELSR2 MATN3	1.90e-06	122	57	6	SM00179
Domain	EGF_LAM_2	HSPG2 STAB2 CELSR2 LAMA3	2.01e-06	30	57	4	PS50027
Domain	EGF_LAM_1	HSPG2 STAB2 CELSR2 LAMA3	2.01e-06	30	57	4	PS01248
Domain	EGF-like_Ca-bd_dom	SNED1 HSPG2 FAT1 STAB2 CELSR2 MATN3	2.09e-06	124	57	6	IPR001881
Domain	Retinoid-X_rcpt/HNF4	NR2E3 HNF4A HNF4G	3.19e-06	10	57	3	IPR000003
Domain	EGF_Lam	HSPG2 STAB2 CELSR2 LAMA3	3.80e-06	35	57	4	SM00180
Domain	Laminin_EGF	HSPG2 STAB2 CELSR2 LAMA3	5.33e-06	38	57	4	IPR002049
Domain	Growth_fac_rcpt_	HSPG2 FAT1 STAB2 CELSR2 MATN3 LAMA3	7.87e-06	156	57	6	IPR009030
Domain	-	HSPG2 FAT1 CELSR2 NRXN2 LAMA3	1.04e-05	95	57	5	2.60.120.200
Domain	ROR_rcpt	RORB RORC	2.74e-05	3	57	2	IPR003079
Domain	Laminin_EGF	HSPG2 CELSR2 LAMA3	1.65e-04	35	57	3	PF00053
Domain	LAMININ_IVA	HSPG2 LAMA3	2.53e-04	8	57	2	PS51115
Domain	Laminin_B	HSPG2 LAMA3	2.53e-04	8	57	2	PF00052
Domain	LamB	HSPG2 LAMA3	2.53e-04	8	57	2	SM00281
Domain	Laminin_IV	HSPG2 LAMA3	2.53e-04	8	57	2	IPR000034
Domain	ConA-like_dom	HSPG2 FAT1 CELSR2 NRXN2 LAMA3	5.40e-04	219	57	5	IPR013320
Domain	GOLGA2L5	GOLGA8B GOLGA8A	1.36e-03	18	57	2	PF15070
Domain	Golgin_A	GOLGA8B GOLGA8A	1.36e-03	18	57	2	IPR024858
Domain	hEGF	SNED1 CELSR2	3.29e-03	28	57	2	PF12661
Domain	ASX_HYDROXYL	SNED1 FAT1 CELSR2	3.53e-03	100	57	3	PS00010
Domain	EGF-type_Asp/Asn_hydroxyl_site	SNED1 FAT1 CELSR2	4.16e-03	106	57	3	IPR000152
Domain	LDLR_class-A_CS	HSPG2 CFI	6.63e-03	40	57	2	IPR023415
Domain	Ldl_recept_a	HSPG2 CFI	8.33e-03	45	57	2	PF00057
Domain	-	HSPG2 CFI	8.69e-03	46	57	2	4.10.400.10
Pathway	REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY	NR2C2 NR2F6 NR2E3 RORB RORC NR3C1 HNF4A HNF4G NR2F1 PGR	6.63e-16	53	45	10	M8276
Pathway	REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY	NR2C2 NR2F6 NR2E3 RORB RORC NR3C1 HNF4A NR2F1 PGR	2.25e-14	48	45	9	MM14987
Pathway	WP_NUCLEAR_RECEPTORS	NR2C2 NR2F6 RORC NR3C1 HNF4A NR2F1 PGR	2.43e-11	38	45	7	M39657
Pathway	WP_NUCLEAR_RECEPTORS	NR2C2 NR2F6 RORC NR3C1 HNF4A NR2F1 PGR	2.43e-11	38	45	7	MM15865
Pathway	REACTOME_ECM_PROTEOGLYCANS	HSPG2 DSPP MATN3 LAMA3 ITGA9	4.12e-06	76	45	5	M27219
Pathway	REACTOME_GENERIC_TRANSCRIPTION_PATHWAY	NR2C2 NR2F6 BRPF3 NR2E3 ZNF814 RORB RORC NR3C1 HNF4A NR2F1 PGR	2.16e-05	768	45	11	MM14851
Pathway	REACTOME_GENE_EXPRESSION_TRANSCRIPTION	NR2C2 NR2F6 BRPF3 NR2E3 POLR1A ZNF814 RORB RORC NR3C1 HNF4A NR2F1 PGR	6.05e-05	1022	45	12	MM15436
Pathway	REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION	NR2C2 NR2F6 BRPF3 NR2E3 ZNF577 ZNF480 RORB RORC NR3C1 HNF4A HNF4G NR2F1 PGR	2.76e-04	1387	45	13	M734
Pathway	REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT	INSM1 HNF4A HNF4G	3.20e-04	42	45	3	M17541
Pathway	PID_HNF3B_PATHWAY	AFP NR3C1 HNF4A	3.93e-04	45	45	3	M106
Pathway	REACTOME_ECM_PROTEOGLYCANS	DSPP MATN3 ITGA9	4.47e-04	47	45	3	MM14925
Pubmed	Automated yeast two-hybrid screening for nuclear receptor-interacting proteins.	NR2C2 NR2F6 RORB RORC NR3C1 HNF4A HNF4G NR2F1	6.96e-11	133	59	8	15604093
Pubmed	A signature motif mediating selective interactions of BCL11A with the NR2E/F subfamily of orphan nuclear receptors.	NR2F6 NR2E3 RORB HNF4G NR2F1	3.04e-10	22	59	5	23975195
Pubmed	Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus.	TGFB1I1 NR2F6 NR2E3 RORC NR3C1 HNF4A HNF4G NR2F1 PGR	6.37e-10	263	59	9	20932939
Pubmed	A dynamic expression survey identifies transcription factors relevant in mouse digestive tract development.	NR2E3 RORC NR3C1 HNF4A HNF4G NR2F1 PGR	1.27e-09	118	59	7	16971476
Pubmed	Nuclear orphan receptors regulate transcription of the gene for the human luteinizing hormone receptor.	NR2C2 NR2F6 NR2F1	4.64e-09	3	59	3	10644740
Pubmed	UBXD4, a UBX-containing protein, regulates the cell surface number and stability of alpha3-containing nicotinic acetylcholine receptors.	CELSR2 ENPP1 GOLGA8B GOLGA8A	1.09e-07	26	59	4	19474315
Pubmed	An atlas of combinatorial transcriptional regulation in mouse and man.	TGFB1I1 NR2F6 NR2E3 POLR1A RORB RORC RERE NR3C1 HNF4A HNF4G PYGO1	2.29e-07	877	59	11	20211142
Pubmed	A census of human transcription factors: function, expression and evolution.	NR2C2 NR2F6 INSM1 RORB RORC RERE NR3C1 HNF4A HNF4G NR2F1 PGR	3.23e-07	908	59	11	19274049
Pubmed	A multipotent progenitor domain guides pancreatic organogenesis.	NR2C2 NR2F6 RORC NR3C1 HNF4A	4.91e-07	91	59	5	17609113
Pubmed	Differential interaction of nuclear receptors with the putative human transcriptional coactivator hTIF1.	NR3C1 HNF4A PGR	1.31e-06	13	59	3	9115274
Pubmed	Dexamethasone-mediated up-regulation of human CYP2A6 involves the glucocorticoid receptor and increased binding of hepatic nuclear factor 4 alpha to the proximal promoter.	NR3C1 HNF4A	2.83e-06	2	59	2	17978169
Pubmed	Glucocorticoid receptor in T cells mediates protection from autoimmunity in pregnancy.	NR3C1 PGR	2.83e-06	2	59	2	28049829
Pubmed	Glucocorticoid receptor binding to chromatin is selectively controlled by the coregulator Hic-5 and chromatin remodeling enzymes.	TGFB1I1 NR3C1	2.83e-06	2	59	2	28381557
Pubmed	Three-dimensional interactions between enhancers and promoters during intestinal differentiation depend upon HNF4.	HNF4A HNF4G	2.83e-06	2	59	2	33503426
Pubmed	Intestine-specific ablation of the Hepatocyte Nuclear Factor 4a (Hnf4a) gene in mice has minimal impact on serum lipids and ileum gene expression profile due to upregulation of its paralog Hnf4g.	HNF4A HNF4G	2.83e-06	2	59	2	34973414
Pubmed	Anthrax lethal factor represses glucocorticoid and progesterone receptor activity.	NR3C1 PGR	2.83e-06	2	59	2	12724519
Pubmed	Proteomic analysis of native hepatocyte nuclear factor-4α (HNF4α) isoforms, phosphorylation status, and interactive cofactors.	HNF4A HNF4G	2.83e-06	2	59	2	21047794
Pubmed	Progesterone receptor polymorphisms and risk of breast cancer: results from two Australian breast cancer studies.	NR3C1 PGR	2.83e-06	2	59	2	17592773
Pubmed	Progesterone and glucocorticoid receptors recruit distinct coactivator complexes and promote distinct patterns of local chromatin modification.	NR3C1 PGR	2.83e-06	2	59	2	12748280
Pubmed	Hepatocyte nuclear factor 4 is a transcription factor that constitutively binds fatty acids.	HNF4A HNF4G	2.83e-06	2	59	2	12220494
Pubmed	Increased acetylation in the DNA-binding domain of TR4 nuclear receptor by the coregulator ARA55 leads to suppression of TR4 transactivation.	TGFB1I1 NR2C2	2.83e-06	2	59	2	21515881
Pubmed	Protein expression of nuclear receptors in human and murine tissues.	HNF4A PGR	2.83e-06	2	59	2	19154258
Pubmed	Progesterone receptor (PROGINS) polymorphism and the risk of endometrial cancer development.	NR3C1 PGR	2.83e-06	2	59	2	17291258
Pubmed	Human hepatocyte nuclear factor 4 isoforms are encoded by distinct and differentially expressed genes.	HNF4A HNF4G	2.83e-06	2	59	2	8622695
Pubmed	Identification of two novel members of erbA superfamily by molecular cloning: the gene products of the two are highly related to each other.	NR2F6 NR2F1	2.83e-06	2	59	2	2905047
Pubmed	Interaction of the tau2 transcriptional activation domain of glucocorticoid receptor with a novel steroid receptor coactivator, Hic-5, which localizes to both focal adhesions and the nuclear matrix.	TGFB1I1 NR3C1	2.83e-06	2	59	2	10848625
Pubmed	Uterine glucocorticoid receptors are critical for fertility in mice through control of embryo implantation and decidualization.	NR3C1 PGR	2.83e-06	2	59	2	26598666
Pubmed	The glucocorticoid receptor interferes with progesterone receptor-dependent genomic regulation in breast cancer cells.	NR3C1 PGR	2.83e-06	2	59	2	31598691
Pubmed	Expression of HNF4alpha isoforms in mouse liver development is regulated by sequential promoter usage and constitutive 3' end splicing.	AFP HNF4A	2.83e-06	2	59	2	11731232
Pubmed	Progesterone receptor variation and risk of ovarian cancer is limited to the invasive endometrioid subtype: results from the Ovarian Cancer Association Consortium pooled analysis.	NR3C1 PGR	2.83e-06	2	59	2	18219286
Pubmed	Suppression of hepatitis B virus core promoter by the nuclear orphan receptor TR4.	NR2C2 HNF4A	2.83e-06	2	59	2	12522137
Pubmed	Different chromatin and DNA sequence characteristics define glucocorticoid receptor binding sites that are blocked or not blocked by coregulator Hic-5.	TGFB1I1 NR3C1	2.83e-06	2	59	2	29738565
Pubmed	Human autoantibodies to a novel Golgi protein golgin-67: high similarity with golgin-95/gm 130 autoantigen.	GOLGA8B GOLGA8A	2.83e-06	2	59	2	10677249
Pubmed	Association of progesterone receptor gene polymorphism (PROGINS) with endometriosis, uterine fibroids and breast cancer.	NR3C1 PGR	2.83e-06	2	59	2	17522428
Pubmed	Induction of Hepatic Metabolic Functions by a Novel Variant of Hepatocyte Nuclear Factor 4γ.	HNF4A HNF4G	2.83e-06	2	59	2	30224520
Pubmed	Distinct modes of regulation of transcription of hepatitis B virus by the nuclear receptors HNF4alpha and COUP-TF1.	HNF4A NR2F1	2.83e-06	2	59	2	12551987
Pubmed	Crosstalk of hepatocyte nuclear factor 4a and glucocorticoid receptor in the regulation of lipid metabolism in mice fed a high-fat-high-sugar diet.	NR3C1 HNF4A	2.83e-06	2	59	2	35614477
Pubmed	Glucose Tolerance Is Improved in Mice Invalidated for the Nuclear Receptor HNF-4γ: A Critical Role for Enteroendocrine Cell Lineage.	HNF4A HNF4G	2.83e-06	2	59	2	25829452
Pubmed	Testicular Receptor-4: Novel Regulator of Glucocorticoid Resistance.	NR2C2 NR3C1	2.83e-06	2	59	2	27253665
Pubmed	Identification and characterization of a novel Golgi protein, golgin-67.	GOLGA8B GOLGA8A	2.83e-06	2	59	2	10660574
Pubmed	Characterization of glucocorticoid receptor and hepatocyte nuclear factor 4alpha (HNF4alpha) binding to the hnf4alpha gene in the liver.	NR3C1 HNF4A	2.83e-06	2	59	2	19540905
Pubmed	A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.	ZBTB49 NR2E3 RORC NR3C1 HNF4A HNF4G NR2F1 PGR PYGO1	2.92e-06	709	59	9	22988430
Pubmed	Deletion of IFT20 exclusively in the RPE ablates primary cilia and leads to retinal degeneration.	GATD3 GOLGA8B GOLGA8A	4.41e-06	19	59	3	38048369
Pubmed	A reinforcing HNF4-SMAD4 feed-forward module stabilizes enterocyte identity.	HNF4A HNF4G	8.48e-06	3	59	2	30988513
Pubmed	The nuclear receptor HNF4 drives a brush border gene program conserved across murine intestine, kidney, and embryonic yolk sac.	HNF4A HNF4G	8.48e-06	3	59	2	34001900
Pubmed	Genome-Wide ChIPseq Analysis of AhR, COUP-TF, and HNF4 Enrichment in TCDD-Treated Mouse Liver.	HNF4A NR2F1	8.48e-06	3	59	2	35163483
Pubmed	Disruption of the glucocorticoid receptor assembly with heat shock protein 90 by a peptidic antiglucocorticoid.	NR3C1 PGR	8.48e-06	3	59	2	9178755
Pubmed	Human ketosteroid receptors interact with hazardous phthalate plasticizers and their metabolites: an in silico study.	NR3C1 PGR	8.48e-06	3	59	2	26304264
Pubmed	ERK8 down-regulates transactivation of the glucocorticoid receptor through Hic-5.	TGFB1I1 NR3C1	8.48e-06	3	59	2	16624805
Pubmed	Glucocorticoid receptor regulates organic cation transporter 1 (OCT1, SLC22A1) expression via HNF4α upregulation in primary human hepatocytes.	NR3C1 HNF4A	8.48e-06	3	59	2	24399729
Pubmed	Atrophin proteins interact with the Fat1 cadherin and regulate migration and orientation in vascular smooth muscle cells.	FAT1 RERE	8.48e-06	3	59	2	19131340
Pubmed	Reduced expression of 15-hydroxy prostaglandin dehydrogenase in chorion during labor is associated with decreased PRB and increased PRA and GR expression.	NR3C1 PGR	8.48e-06	3	59	2	23506845
Pubmed	Interplay of nuclear receptors (ER, PR, and GR) and their steroid hormones in MCF-7 cells.	NR3C1 PGR	8.48e-06	3	59	2	27632388
Pubmed	Activation of the GDNF-inducible transcription factor (GIF) gene promoter by glucocorticoid and progesterone.	NR3C1 PGR	8.48e-06	3	59	2	19429458
Pubmed	Transcriptional control of the human aldehyde dehydrogenase 2 promoter by hepatocyte nuclear factor 4: inhibition by cyclic AMP and COUP transcription factors.	HNF4A NR2F1	8.48e-06	3	59	2	11811951
Pubmed	The nuclear orphan receptor NR2F6 suppresses lymphocyte activation and T helper 17-dependent autoimmunity.	NR2F6 NR2F1	8.48e-06	3	59	2	18701084
Pubmed	Gestational stress induces the unfolded protein response, resulting in heart defects.	SPRY1 GOLGA8B GOLGA8A	1.04e-05	25	59	3	27436040
Pubmed	Stepwise reprogramming of liver cells to a pancreas progenitor state by the transcriptional regulator Tgif2.	AFP INSM1 HNF4A	1.17e-05	26	59	3	28193997
Pubmed	PTEN dephosphorylates Abi1 to promote epithelial morphogenesis.	HSPG2 GOLGA8B GOLGA8A	1.17e-05	26	59	3	32673396
Pubmed	Tbr1 regulates regional and laminar identity of postmitotic neurons in developing neocortex.	SPRY1 RORB NR2F1	1.64e-05	29	59	3	20615956
Pubmed	Hepatocyte nuclear factor-4 alpha/gamma and hepatocyte nuclear factor-1 alpha as causal factors of interindividual difference in the expression of human dihydrodiol dehydrogenase 4 mRNA in human livers.	HNF4A HNF4G	1.69e-05	4	59	2	12544512
Pubmed	Gain in transcriptional activity by primate-specific coevolution of melanoma antigen-A11 and its interaction site in androgen receptor.	NR3C1 PGR	1.69e-05	4	59	2	21730049
Pubmed	Regulation of vascular endothelial growth factor D by orphan receptors hepatocyte nuclear factor-4 alpha and chicken ovalbumin upstream promoter transcription factors 1 and 2.	HNF4A NR2F1	1.69e-05	4	59	2	18199540
Pubmed	Progesterone, glucocorticoid, but not estrogen receptor mRNA is altered in breast cancer stroma.	NR3C1 PGR	1.69e-05	4	59	2	17512111
Pubmed	Recurrent CNVs disrupt three candidate genes in schizophrenia patients.	ASTN2 CTNND2	1.69e-05	4	59	2	18940311
Pubmed	Members of the steroid hormone receptor superfamily interact with TFIIB (S300-II).	NR2F1 PGR	1.69e-05	4	59	2	1517211
Pubmed	Progesterone receptor repression of prolactin/signal transducer and activator of transcription 5-mediated transcription of the beta-casein gene in mammary epithelial cells.	NR3C1 PGR	1.69e-05	4	59	2	16973758
Pubmed	NR2F1 disrupts synergistic activation of the MTTP gene transcription by HNF-4α and HNF-1α.	HNF4A NR2F1	1.69e-05	4	59	2	22357705
Pubmed	The nuclear orphan receptor COUP-TFI is required for differentiation of subplate neurons and guidance of thalamocortical axons.	RORB NR2F1	1.69e-05	4	59	2	10624948
Pubmed	Transcription activation by the orphan nuclear receptor, chicken ovalbumin upstream promoter-transcription factor I (COUP-TFI). Definition of the domain involved in the glucocorticoid response of the phosphoenolpyruvate carboxykinase gene.	HNF4A NR2F1	2.82e-05	5	59	2	10652338
Pubmed	Progesterone acts via the nuclear glucocorticoid receptor to suppress IL-1β-induced COX-2 expression in human term myometrial cells.	NR3C1 PGR	2.82e-05	5	59	2	23209664
Pubmed	Regulation of nuclear receptor transcriptional activity by a novel DEAD box RNA helicase (DP97).	NR3C1 PGR	2.82e-05	5	59	2	12466272
Pubmed	Embryonic liver developmental trajectory revealed by single-cell RNA sequencing in the Foxa2eGFP mouse.	AFP HNF4A	2.82e-05	5	59	2	33144666
Pubmed	MFGE8 links absorption of dietary fatty acids with catabolism of enterocyte lipid stores through HNF4γ-dependent transcription of CES enzymes.	HNF4A HNF4G	2.82e-05	5	59	2	36924494
Pubmed	Genomic organization, chromosomal mapping, and promoter analysis of the mouse dentin sialophosphoprotein (Dspp) gene, which codes for both dentin sialoprotein and dentin phosphoprotein.	DSPP AFP	2.82e-05	5	59	2	9545272
Pubmed	The cochaperone SGTA (small glutamine-rich tetratricopeptide repeat-containing protein alpha) demonstrates regulatory specificity for the androgen, glucocorticoid, and progesterone receptors.	NR3C1 PGR	2.82e-05	5	59	2	24753260
Pubmed	Human CYP2C8 is transcriptionally regulated by the nuclear receptors constitutive androstane receptor, pregnane X receptor, glucocorticoid receptor, and hepatic nuclear factor 4alpha.	NR3C1 HNF4A	2.82e-05	5	59	2	15933212
Pubmed	The orphan nuclear receptor Ear-2 is a negative coregulator for thyroid hormone nuclear receptor function.	NR2F6 NR3C1	2.82e-05	5	59	2	10713182
Pubmed	C/EBPalpha and C/EBPbeta are markers of early liver development.	AFP HNF4A	2.82e-05	5	59	2	16892179
Pubmed	High-mobility group chromatin proteins 1 and 2 functionally interact with steroid hormone receptors to enhance their DNA binding in vitro and transcriptional activity in mammalian cells.	NR3C1 PGR	2.82e-05	5	59	2	9671457
Pubmed	Conditional regulation of the human CYP4X1 and CYP4Z1 genes.	NR3C1 PGR	2.82e-05	5	59	2	15797250
Pubmed	Impact of cytosine methylation on DNA binding specificities of human transcription factors.	NR2C2 NR2F6 RORB RORC NR3C1 HNF4A NR2F1	3.72e-05	544	59	7	28473536
Pubmed	Supervillin associates with androgen receptor and modulates its transcriptional activity.	TGFB1I1 NR3C1	4.23e-05	6	59	2	11792840
Pubmed	Role of a BCL9-related beta-catenin-binding protein, B9L, in tumorigenesis induced by aberrant activation of Wnt signaling.	HNF4A PYGO1	4.23e-05	6	59	2	15574752
Pubmed	Cloning and expression during development of three murine members of the COUP family of nuclear orphan receptors.	NR2F6 NR2F1	4.23e-05	6	59	2	7947324
Pubmed	Immunohistochemical characterization of the orphan nuclear receptor ROR alpha in the mouse nervous system.	RORB RORC	4.23e-05	6	59	2	14966198
Pubmed	Hnf4 activates mimetic-cell enhancers to recapitulate gut and liver development within the thymus.	HNF4A HNF4G	4.23e-05	6	59	2	37399024
Pubmed	Fibroblast growth factor receptor 3 kinase domain mutation increases cortical progenitor proliferation via mitogen-activated protein kinase activation.	SPRY1 NR2F1	4.23e-05	6	59	2	17181553
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	USP50 CTTNBP2 POLR1A ARHGEF10 AFP SNRNP40 RRP15 ATG2A LANCL2	4.66e-05	1005	59	9	19615732
Pubmed	The potassium channel KCNJ13 is essential for smooth muscle cytoskeletal organization during mouse tracheal tubulogenesis.	CELSR2 GOLGA8B GOLGA8A	4.72e-05	41	59	3	30022023
Pubmed	BCAS2 regulates oocyte meiotic prophase I by participating in mRNA alternative splicing.	GOLGA8B GOLGA8A PGR	5.84e-05	44	59	3	38085152
Pubmed	Functional interactions between Fat family cadherins in tissue morphogenesis and planar polarity.	FAT1 RERE	5.91e-05	7	59	2	22510986
Pubmed	GATA-4/-6 and HNF-1/-4 families of transcription factors control the transcriptional regulation of the murine Muc5ac mucin during stomach development and in epithelial cancer cells.	HNF4A HNF4G	5.91e-05	7	59	2	22554936
Pubmed	COUP-TFI: an intrinsic factor for early regionalization of the neocortex.	RORB NR2F1	5.91e-05	7	59	2	11511537
Pubmed	A lifespan analysis of intraneocortical connections and gene expression in the mouse II.	RORB NR2F1	5.91e-05	7	59	2	21060113
Pubmed	A lifespan analysis of intraneocortical connections and gene expression in the mouse I.	RORB NR2F1	5.91e-05	7	59	2	21060110
Pubmed	Nuclear receptor coactivator 6 mediates the synergistic activation of human cytochrome P-450 2C9 by the constitutive androstane receptor and hepatic nuclear factor-4alpha.	HNF4A TGS1	7.87e-05	8	59	2	18552123
Pubmed	ARIP3 (androgen receptor-interacting protein 3) and other PIAS (protein inhibitor of activated STAT) proteins differ in their ability to modulate steroid receptor-dependent transcriptional activation.	NR3C1 PGR	7.87e-05	8	59	2	11117529
Pubmed	Nr2f1 heterozygous knockout mice recapitulate neurological phenotypes of Bosch-Boonstra-Schaaf optic atrophy syndrome and show impaired hippocampal synaptic plasticity.	HSPG2 NR2F1	7.87e-05	8	59	2	31600777
Pubmed	Multi-stage analysis of differential gene expression in BALB/C mouse liver development by high-density microarrays.	AFP HNF4A	7.87e-05	8	59	2	12558604
Interaction	NCOA1 interactions	NR2F6 RORB NR3C1 HNF4A HNF4G NR2F1 PGR	1.77e-07	146	57	7	int:NCOA1
Interaction	NCOA3 interactions	RORB RORC NR3C1 HNF4A HNF4G NR2F1 PGR	3.15e-06	224	57	7	int:NCOA3
Interaction	NR0B1 interactions	SNRNP40 NR3C1 HNF4A PGR	4.87e-06	40	57	4	int:NR0B1
Interaction	YEATS2 interactions	NR2C2 BRPF3 SNRNP40 RERE NR3C1 HNF4A	8.10e-06	169	57	6	int:YEATS2
Interaction	NR2E3 interactions	NR2E3 DDI1 NR3C1	2.75e-05	21	57	3	int:NR2E3
Interaction	PNRC1 interactions	RORB HNF4A HNF4G	3.65e-05	23	57	3	int:PNRC1
Interaction	POU2F2 interactions	NR3C1 NR2F1 PGR	5.33e-05	26	57	3	int:POU2F2
Interaction	NCOA6 interactions	RORB RORC NR3C1 HNF4A TGS1	5.58e-05	145	57	5	int:NCOA6
Interaction	NCOR2 interactions	SNRNP40 HELZ NR3C1 HNF4A NR2F1 PGR	9.90e-05	264	57	6	int:NCOR2
Cytoband	15q21.1	USP50 PYGO1	1.05e-03	37	59	2	15q21.1
GeneFamily	Nuclear hormone receptors	NR2C2 NR2F6 NR2E3 RORB RORC NR3C1 HNF4A HNF4G NR2F1 PGR	6.40e-18	49	40	10	71
Coexpression	MIKI_COEXPRESSED_WITH_CYP19A1	NR2C2 NR2E3 HNF4A	3.77e-07	7	59	3	M1868
Coexpression	HAY_BONE_MARROW_STROMAL	HSPG2 SPRY1 FAT1 NRXN2 ARHGEF10 MATN3 RORB CFI NR2F1 PYGO1	7.46e-06	767	59	10	M39209
Coexpression	INGRAM_SHH_TARGETS_UP	SPRY1 ARHGEF10 DSPP ENPP1 NR3C1	9.27e-06	125	59	5	M1320
Coexpression	INGRAM_SHH_TARGETS_UP	SPRY1 ARHGEF10 DSPP ENPP1 NR3C1	2.71e-05	156	59	5	MM550
Coexpression	GOZGIT_ESR1_TARGETS_DN	ARG2 FAT1 CELSR2 DSPP ENPP1 MATN3 MACROD2 CTNND2 PGR	6.15e-05	786	59	9	M10961
CoexpressionAtlas	DevelopingKidney_e14.5 whole kidney - wildtype_emap-6674_k-means-cluster#2_top-relative-expression-ranked_1000	ARG2 SPRY1 CELSR2 CNDP2 LANCL2	3.66e-05	145	55	5	gudmap_developingKidney_e14.5 whole kidney - wildtype_1000_k2
CoexpressionAtlas	DevelopingKidney_e15.5_Pelvic Mesenchyme_emap-8241_k-means-cluster#1_top-relative-expression-ranked_500	ARG2 AFP HNF4A	7.73e-05	32	55	3	gudmap_developingKidney_e15.5_Pelvic Mesenchyme_500_k1
CoexpressionAtlas	DevelopingKidney_e15.5_ureter tip_flank cortic collct_emap-27752_k-means-cluster#4_top-relative-expression-ranked_1000	ARG2 SPRY1 CNDP2 DCBLD1 CTNND2	1.16e-04	185	55	5	gudmap_developingKidney_e15.5_ureter tip_flank cortic collct_1000_k4
CoexpressionAtlas	DevelopingKidney_e11.5_ureteric bud_emap-3844_k-means-cluster#3_top-relative-expression-ranked_500	ARG2 SPRY1 CNDP2 DCBLD1 CTNND2	1.42e-04	193	55	5	gudmap_developingKidney_e11.5_ureteric bud_500_k3
CoexpressionAtlas	DevelopingKidney_e14.5 whole kidney - wildtype_emap-6674_k-means-cluster#2_top-relative-expression-ranked_500	ARG2 AFP CFI HNF4A	1.47e-04	103	55	4	gudmap_developingKidney_e14.5 whole kidney - wildtype_500_k2
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	HSPG2 MACROD2 LAMA3 GOLGA8B CTNND2 GOLGA8A	1.78e-07	187	59	6	4ae7465174e0295d2c3b614b321a3b2f514dd22a
ToppCell	background-Endothelial_cells\|background / Sample and Cell Type and Tumor Cluster (all cells)	SNED1 HSPG2 ZBTB46 STAB2 ITGA9 NR2F1	2.35e-07	196	59	6	e6fb0bfab1779ec64a8c35d01519eaafbf62e977
ToppCell	medial-Endothelial-Lymphatic-2\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	HSPG2 SPRY1 STAB2 ITGA9 CFI NR2F1	2.50e-07	198	59	6	41983d405215b974044e2e9e6c212b134336a6fe
ToppCell	medial-2-Endothelial-Lymphatic\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	HSPG2 SPRY1 STAB2 ITGA9 CFI NR2F1	2.50e-07	198	59	6	e4274584512a72270087a1ab104fab449a2f83bc
ToppCell	medial-Endothelial-Lymphatic\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	HSPG2 SPRY1 STAB2 ITGA9 CFI NR2F1	2.50e-07	198	59	6	1760fede363544bc0fa2e22fe36aff522abd2525
ToppCell	10x_3'_v2v3-Neoplastic-Stem-like-OPC-like-OPC-like_Prolif-E\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	HSPG2 FAT1 CELSR2 LANCL2 PYGO1	2.99e-06	169	59	5	2833a8a7094e4d407eb923f2bc59b9b112c6bae4
ToppCell	COVID-19-kidney-tDL\|COVID-19 / Disease (COVID-19 only), tissue and cell type	FAT1 ENPP1 ASTN2 HNF4A HNF4G	4.07e-06	180	59	5	864c895b5eaedefae86f5829fa344f7b686fb59f
ToppCell	E12.5-Epithelial-epithelial_progenitor_cell-epi_progenitor\|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	ARG2 SPRY1 LAMA3 CTNND2 CFI	4.42e-06	183	59	5	031b4ffd95114dc10d2932c67d2cfef139b3fd2e
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TGFB1I1 SPRY1 FAT1 NR2F1 PGR	4.53e-06	184	59	5	102b6f621a5b551e622f97b12d787c080b052a72
ToppCell	367C-Myeloid-Dendritic-cDC1\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	ZBTB46 ENPP1 MACROD2 GOLGA8B CTNND2	4.91e-06	187	59	5	3748203b62abf51b74dfcfc4f18b3ba831b63a96
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	HSPG2 MACROD2 LAMA3 GOLGA8B GOLGA8A	5.04e-06	188	59	5	eea652bab161f19148a883e7e3fe2523b36b3cea
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-lymphatic_endothelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	HSPG2 SPRY1 STAB2 ITGA9 NR2F1	5.04e-06	188	59	5	26915db8863f4115b46a81982e187322e21600fd
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	HSPG2 SPRY1 STAB2 ITGA9 NR2F1	5.04e-06	188	59	5	3f76c0f912f8f023ea425be7f43593b3d7f967e3
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	HSPG2 SPRY1 STAB2 ITGA9 NR2F1	5.04e-06	188	59	5	61ee7b152745164293d8a44ef91ee2393efbdca5
ToppCell	Mesenchymal-myofibroblast_cell\|World / Lineage, Cell type, age group and donor	SNED1 SPRY1 FAT1 ITGA9 NR2F1	5.17e-06	189	59	5	44e37f88137bb249933eb615235b2cf2ae7f3925
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c09-SLC4A10\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	SPRY1 GOLGA8B ATG2A CTNND2 GOLGA8A	5.30e-06	190	59	5	05e6af222d0ad97cb69f399a96c9038f9dd989b9
ToppCell	10x5'v1-week_17-19-Endothelial-stroma-proliferating_EC\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	SNED1 HSPG2 STAB2 NR2F1 PYGO1	5.44e-06	191	59	5	dc9e5eb6aa31b8d79aeec33e59b9138dfb469a3b
ToppCell	human_hepatoblastoma-Tumor_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	AKAP9 AFP MACROD2 HELZ RERE	5.58e-06	192	59	5	916fbec1c7ab7969bda711886ac88e877e30c280
ToppCell	10x5'-lymph-node_spleen-Lymphocytic_Invariant-Inducer-like-ILC3\|lymph-node_spleen / Manually curated celltypes from each tissue	SPRY1 ZBTB46 ENPP1 RORC CTNND2	5.58e-06	192	59	5	e16035b3328f9b1b2e28d234c62ba88387540550
ToppCell	facs-Liver-Liver_non-hepato/SCs-18m-Endothelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STAB2 NRXN2 ARHGEF10 FAM124A ITGA9	5.72e-06	193	59	5	2483bb7f398e4fa0ef09c8bd584ed25703853f03
ToppCell	human_hepatoblastoma\|World / Sample and Cell Type and Tumor Cluster (all cells)	AKAP9 AFP MACROD2 HELZ RERE	5.72e-06	193	59	5	e6a688bc834f845ff64dae1be64f073eec5091a1
ToppCell	3'_v3-Lung-Mast\|Lung / Manually curated celltypes from each tissue	TGFB1I1 HSPG2 FAT1 CTTNBP2 ITGA9	5.87e-06	194	59	5	5e6eb81ddc9d5e22c1297734689f476d5a05bff6
ToppCell	3'_v3-Lung-Mast-Mast_cells\|Lung / Manually curated celltypes from each tissue	TGFB1I1 HSPG2 FAT1 CTTNBP2 ITGA9	5.87e-06	194	59	5	7b7f1714c4a9d9519c4d0e460cb87f2eb82392dd
ToppCell	facs-Liver-Liver_non-hepato/SCs-18m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 STAB2 NRXN2 FAM124A ITGA9	6.32e-06	197	59	5	d584d0334ea97e3fa8c4cd869f5eeea2c7a1ed04
ToppCell	Tracheal-10x3prime_v2-Stromal-Mesofibroblastic\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	ZBTB49 CTTNBP2 ENPP1 NR2F1 PGR	6.32e-06	197	59	5	d7cef7881abd807a679432766ced609a6efd1067
ToppCell	10x3'2.3-week_17-19-Endothelial-stroma-sinusoidal_EC\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	HSPG2 STAB2 CTTNBP2 CFI NR2F1	6.32e-06	197	59	5	4e58bbf3ecb30b4c8199adcc04d2eb134d90de56
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SNED1 HSPG2 SPRY1 ZBTB46 ITGA9	6.32e-06	197	59	5	0f467ef58f0c4dcc00b34b7b9639e03fb3ebe780
ToppCell	facs-Liver-Liver_non-hepato/SCs-18m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 STAB2 NRXN2 FAM124A ITGA9	6.32e-06	197	59	5	412091994196a06c2779b4c2cfed84be889a5f8d
ToppCell	normal_Lung-Epithelial_cells-AT1\|Epithelial_cells / Location, Cell class and cell subclass	HSPG2 MATN3 LAMA3 GOLGA8B GOLGA8A	6.32e-06	197	59	5	7d19b93d6853828e2a036e37c4887edb1de4503c
ToppCell	Tracheal-10x3prime_v2-Stromal-Mesofibroblastic-Mesothelia\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	ZBTB49 CTTNBP2 ENPP1 NR2F1 PGR	6.32e-06	197	59	5	20a5958512bdb99daeb8f4d244df53e4f048f879
ToppCell	Biopsy_IPF-Epithelial-AT1\|Biopsy_IPF / Sample group, Lineage and Cell type	HSPG2 MATN3 LAMA3 GOLGA8B GOLGA8A	6.48e-06	198	59	5	75bdecbe111fededf6082b11de18b84ca308ef6d
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SNED1 HSPG2 SPRY1 ZBTB46 ITGA9	6.48e-06	198	59	5	1378c6d4ceb84b42fdd6556be3296df7a8059e6e
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SNED1 HSPG2 SPRY1 ZBTB46 ITGA9	6.48e-06	198	59	5	451003a21162eeae90739fdb502bb50b362d80c8
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SNED1 HSPG2 SPRY1 ZBTB46 ITGA9	6.48e-06	198	59	5	440af8f90c7afa1c07000806bcf9110b70f489fb
ToppCell	LPS_IL1RA-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	TGFB1I1 SPRY1 FAT1 NRXN2 ITGA9	6.64e-06	199	59	5	6b3a0e5d52a30d0eed30e6a670f5b53bc233f70c
ToppCell	distal-mesenchymal-Pericyte-3\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	TGFB1I1 SPRY1 FAT1 MATN3 NR2F1	6.64e-06	199	59	5	000d9b5f5a48e56f0733390adb3d7270c49a4a1a
ToppCell	distal-3-mesenchymal-Pericyte\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	TGFB1I1 SPRY1 FAT1 MATN3 NR2F1	6.80e-06	200	59	5	911db29f254bb697610e720ba78816e2c7f57933
ToppCell	Biopsy_Control_(H.)-Epithelial-AT1\|Biopsy_Control_(H.) / Sample group, Lineage and Cell type	HSPG2 MATN3 LAMA3 GOLGA8B GOLGA8A	6.80e-06	200	59	5	3a9633f5913f12b6865fc777c84f3f3ba795a78d
ToppCell	Biopsy_Other_PF-Epithelial-Basal\|Biopsy_Other_PF / Sample group, Lineage and Cell type	ARG2 FAT1 CELSR2 MACROD2 LAMA3	6.80e-06	200	59	5	7098ae4b0ea8ba607519eaed8577c577530fc2a1
ToppCell	COVID-19_Moderate-multiplets\|COVID-19_Moderate / disease group, cell group and cell class	ARHGEF10 ENPP1 GOLGA8B CTNND2	4.33e-05	147	59	4	baf15c773d7751bc6f64d4974a22738626f2b3ff
ToppCell	3'_v3-blood-Lymphocytic_Invariant-Inducer-like\|blood / Manually curated celltypes from each tissue	SPRY1 ENPP1 LAMA3 RORC	4.56e-05	149	59	4	75422e1a22736375e9ef439db0b2a5efa3f653a3
ToppCell	COVID-19_Moderate-multiplets\|World / disease group, cell group and cell class	ENPP1 GOLGA8B CTNND2 GOLGA8A	5.46e-05	156	59	4	afdc025fa75e7926b1cc182c4a33654a2186abb1
ToppCell	Children_(3_yrs)-Epithelial-basal_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	MACROD2 GOLGA8B ITGA9 GOLGA8A	5.59e-05	157	59	4	6ee2692f705bdd93ba523dffaf2f0cd921b47e28
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	FAT1 MACROD2 ITGA9 GOLGA8A	5.88e-05	159	59	4	8680b054622f573a82b1625fb93c2d5db81d1034
ToppCell	COVID-19-kidney-Epithelial_(EC)\|kidney / Disease (COVID-19 only), tissue and cell type	HSPG2 SPRY1 CTNND2 ITGA9	6.02e-05	160	59	4	0d4880f85565d8c540c94a8f8109147b3029279a
ToppCell	NS-critical-LOC-Myeloid-Basophil\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	TGFB1I1 FAT1 CTTNBP2 ITGA9	6.02e-05	160	59	4	8a4746463ca1976f7d6de803496c851249ced797
ToppCell	10x5'-bone_marrow-Myeloid_Dendritic-DC1\|bone_marrow / Manually curated celltypes from each tissue	ZBTB46 ENPP1 CTNND2 CFI	6.17e-05	161	59	4	2f068ee643de2f647c289779a6624265ab9a749b
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SNED1 MACROD2 LAMA3 ASTN2	6.32e-05	162	59	4	373513f9d0e5007b2e10a8b78d4909dcce9e3b62
ToppCell	10x5'-Liver-Lymphocytic_Invariant-Inducer-like-ILC3\|Liver / Manually curated celltypes from each tissue	TGFB1I1 FAM124A RORC CTNND2	6.47e-05	163	59	4	7f61483eeb1fde21843c6391468e13cb0cc2a89f
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SNED1 SPRY1 ZBTB46 PGR	6.63e-05	164	59	4	b6df1e67a5ce5f2d86f4e1420f4ee931f760bf4d
ToppCell	343B-Myeloid-Macrophage-FABP4+_Macrophage\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	NR2C2 MACROD2 FAM124A RORB	6.94e-05	166	59	4	f62db9d9b6c9dd8f2afcaea0fc5f8c69f50205b2
ToppCell	ICU-NoSEP-Lymphocyte-T_NK-MAIT\|ICU-NoSEP / Disease, Lineage and Cell Type	SPRY1 DCBLD1 ASTN2 RORC	6.94e-05	166	59	4	d3fa2e42497201f1ca57f4f977fbaa0def950033
ToppCell	3'_v3-Lung-Lymphocytic_Invariant-Inducer-like-ILC3\|Lung / Manually curated celltypes from each tissue	SPRY1 ARHGEF10 ENPP1 RORC	7.11e-05	167	59	4	0614d077b47a87f726068615548d0b0a216627be
ToppCell	3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_I_pneumocyte-AT1-AT1_L.0.5.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	HSPG2 LAMA3 CTNND2 GOLGA8A	7.44e-05	169	59	4	cd16e8462ee09877be962fbd9a3badcb825820b0
ToppCell	E16.5-samps-Epithelial-Alveolar_epithelial_precursor-Uncommitted_AE_cell\|E16.5-samps / Age Group, Lineage, Cell class and subclass	CELSR2 LAMA3 CTNND2 CFI	7.61e-05	170	59	4	5a64e05c263df915085988d881808221e2c0f2e2
ToppCell	5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(nasal)\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ZNF577 CFI GOLGA8A LANCL2	7.61e-05	170	59	4	330b5fc8fde307eda9dcc7bc9053ea8a7e1f0f6d
ToppCell	5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(nasal)-Club_(nasal)_L.0.2.1.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ZNF577 CFI GOLGA8A LANCL2	7.61e-05	170	59	4	0c9d38e89b048166b879e6b4bdf7c5dfe8ab57c4
ToppCell	3'-Distal_airway-Immune_Myeloid-Dendritic-conventional_dendritic_cell-DC1_(conventional_dendritic_cell)\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ZBTB46 ENPP1 ZNF814 CTNND2	7.79e-05	171	59	4	1018d7bd378ce20bee56a77d5851b3538c55098c
ToppCell	3'-Distal_airway-Immune_Myeloid-Dendritic-conventional_dendritic_cell-DC1_(conventional_dendritic_cell)-DC1_L.1.2.1.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ZBTB46 ENPP1 ZNF814 CTNND2	7.79e-05	171	59	4	6bda333bb751d7835a04f21ac959eea79f2516aa
ToppCell	3'-Distal_airway-Immune_Myeloid-Dendritic-conventional_dendritic_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ZBTB46 ENPP1 ZNF814 CTNND2	7.79e-05	171	59	4	173bb5318fdbaef6e695b6f9e3e0ff4a5432a1a4
ToppCell	E12.5-Epithelial-alveolar_epithelial_cell-type_II_pneumocyte\|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	ARG2 SPRY1 AFP CFI	7.79e-05	171	59	4	a4d6b0f57eead11b01153688b06b2a45a3b488f2
ToppCell	Control-Stromal-Pericyte\|World / Disease state, Lineage and Cell class	TGFB1I1 MATN3 DDI1 PGR	7.97e-05	172	59	4	813d4256b05b66ca11b08cc0026459d79f12c0eb
ToppCell	normal_Pleural_Fluid-Myeloid_cells-CD1c+_DCs\|normal_Pleural_Fluid / Location, Cell class and cell subclass	ZBTB46 NRXN2 RORC PGR	7.97e-05	172	59	4	200b2e63313b110b8ca59ee5b72c02cc8ed907cd
ToppCell	Endothelial-Endothelial-G\|Endothelial / shred on cell class and cell subclass (v4)	SNED1 STAB2 NRXN2 ITGA9	7.97e-05	172	59	4	644f8e42ee8d8996f6ae50cdf874559be55509fc
ToppCell	facs-Marrow-KLS-3m-Lymphocytic-immature_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 ENPP1 DCBLD1 LANCL2	8.15e-05	173	59	4	8bffd512a4e561e23cc04478e2ca6fd5d3771fe4
ToppCell	facs-Marrow-KLS-3m-Lymphocytic-immature_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 ENPP1 DCBLD1 LANCL2	8.15e-05	173	59	4	3e3c61468e703330788a10d850ef41a85680f86d
ToppCell	metastatic_Lymph_Node-Endothelial_cells-Lymphatic_ECs\|metastatic_Lymph_Node / Location, Cell class and cell subclass	TGFB1I1 HSPG2 STAB2 ITGA9	8.33e-05	174	59	4	d551bc29afef071adf4c9bb80345352ec33441d8
ToppCell	5'-Adult-Appendix-Mesenchymal-fibroblastic-Stromal_1_(CCL11+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MATN3 CTNND2 NR2F1 PYGO1	8.33e-05	174	59	4	f90ca117b729436cf452e2ddcec26ba525c5c13b
ToppCell	Control-Stromal-Pericyte\|Control / Disease state, Lineage and Cell class	TGFB1I1 MATN3 DDI1 PGR	8.33e-05	174	59	4	91fc1f1c891f105a91968c22e2de5321c52b439a
ToppCell	droplet-Fat-Bat-18m-Mesenchymal-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SNED1 SPRY1 RRP15 FAM124A	8.52e-05	175	59	4	b4f01e7782cdd107d0817ef601891fd3a382bc35
ToppCell	droplet-Fat-Bat-18m-Mesenchymal-mesenchymal_stem_cell_of_adipose\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SNED1 SPRY1 RRP15 FAM124A	8.52e-05	175	59	4	ef6f811d8e1839f405c3b41090ddf79be57a099f
ToppCell	droplet-Fat-Bat-18m-Mesenchymal\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SNED1 SPRY1 RRP15 FAM124A	8.52e-05	175	59	4	7f7598d46d10bff1cbea42f950bdde1aaa16e9a4
ToppCell	AT1_cells-HP_01\|World / lung cells shred on cell class, cell subclass, sample id	HSPG2 MATN3 LAMA3 CTNND2	8.71e-05	176	59	4	458720776b0151cd55acc352d509599cb62f0ca8
ToppCell	AT1_cells-SSc-ILD_02\|World / lung cells shred on cell class, cell subclass, sample id	HSPG2 MATN3 LAMA3 GOLGA8A	8.71e-05	176	59	4	4a30bb771297b30926fb98e2b5ec0dbdc46feac7
ToppCell	droplet-Liver-LIVER_HEP-30m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NR2F6 CTTNBP2 CELSR2 HNF4G	8.71e-05	176	59	4	5e46a09a36b9645b1b1fcb0b64bd0898561af3a9
ToppCell	368C-Lymphocytic-NK_cells-NK_cell_E\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	SPRY1 ENPP1 RORC LANCL2	8.90e-05	177	59	4	946803293a7955116c80f403e99e4093e798ca3f
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ENPP1 RORB NR2F1 PGR	8.90e-05	177	59	4	9ec7f1e64312d26d434b3312b58386715dbad644
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ENPP1 RORB NR2F1 PGR	8.90e-05	177	59	4	016277dfd59b1793fddaaadc2b3f41622d76ce3a
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting-Basal_resting_L.0.0.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MACROD2 CTNND2 ITGA9 GOLGA8A	8.90e-05	177	59	4	75cb2067a3f2d1b5a964890b02b604d1e79bd163
ToppCell	Children_(3_yrs)-Epithelial-basal_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	MACROD2 GOLGA8B ITGA9 GOLGA8A	9.10e-05	178	59	4	fba2e38c05cbf031e0c6d47b1602575fea734a57
ToppCell	AT1_cells-Cryobiopsy_01\|World / lung cells shred on cell class, cell subclass, sample id	HSPG2 MATN3 LAMA3 GOLGA8A	9.29e-05	179	59	4	1603117b52623663458a977c94bf7f9f6c1114b8
ToppCell	5'-Adult-Appendix-Mesenchymal-fibroblastic-Stromal_2_(NPY+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ZBTB46 MATN3 CTNND2 PGR	9.29e-05	179	59	4	a1ea8daa0fe8900f5a04b555c77fe8ebdaa3908d
ToppCell	COVID-19-kidney-PCT-S2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	FAT1 ASTN2 HNF4A HNF4G	9.50e-05	180	59	4	358923e4228035a3e90e2957392089219e90dcd7
ToppCell	3'_v3-lymph-node_spleen-Myeloid_Dendritic-DC1\|lymph-node_spleen / Manually curated celltypes from each tissue	ZBTB46 CTTNBP2 ENPP1 CFI	9.50e-05	180	59	4	a7db1f00566c9acab8b239cbf2e053fb3f2f6a0d
ToppCell	Hippocampus-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a6-Excitatory_Neuron.Slc17a6.Htr1a_(Neuron.Slc17a6.Htr1a)-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	NR2E3 STAB2 DSPP	9.67e-05	67	59	3	be6853b5bf254063f02a4c478fd4c3fef68cb77a
ToppCell	Hippocampus-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a6-Excitatory_Neuron.Slc17a6.Htr1a_(Neuron.Slc17a6.Htr1a)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	NR2E3 STAB2 DSPP	9.67e-05	67	59	3	7483b85423d9d07b01b60927d0fe1b7ccb241d7f
ToppCell	normal_Lung-Fibroblasts-Pericytes\|normal_Lung / Location, Cell class and cell subclass	TGFB1I1 FAT1 MATN3 NR2F1	9.70e-05	181	59	4	f74941e49950027360d71ea3b205fc20c6929766
ToppCell	normal_Pleural_Fluid-Myeloid_cells-CD1c+_DCs\|Myeloid_cells / Location, Cell class and cell subclass	ZBTB46 NRXN2 RORC PGR	9.70e-05	181	59	4	cc7ae1221a28bc404138a7efee0ad08a19cc3d86
ToppCell	COVID-19-kidney-Stressed_PCT\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ENPP1 ASTN2 HNF4A HNF4G	9.70e-05	181	59	4	6980ea624151da32b7f537f263e40fcb87a02e81
ToppCell	ASK454-Epithelial\|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq	MATN3 LAMA3 GOLGA8A PYGO1	9.91e-05	182	59	4	ab15316cff989b61ff397a866d7ca8b49c13e981
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SNED1 MACROD2 LAMA3 ASTN2	9.91e-05	182	59	4	a8cc56f32efe180e8fb5d69dbe606a794b3db700
ToppCell	droplet-Marrow-BM_(NON-STC)-30m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NRXN2 ARHGEF10 LAMA3 CTNND2	9.91e-05	182	59	4	33afbb7c4352b03266501b1f4f0e751c12c7350d
ToppCell	E12.5-Epithelial-epithelial_progenitor_cell-epithelial_progenitor_cell\|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	ARG2 SPRY1 CTNND2 CFI	9.91e-05	182	59	4	204530444e35d4977a7239ac176f477e9e5c29ab
ToppCell	5'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating-Lymphatic_EC_differentiating_L.2.5.1.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SPRY1 STAB2 ITGA9 NR2F1	9.91e-05	182	59	4	53c267ee327e116dbd89d5927ed3bdf78d25ee62
ToppCell	3'-GW_trimst-1-SmallIntestine-Endothelial-lymphatic_endothelial-LEC1_(ACKR4+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	STAB2 ITGA9 CFI NR2F1	9.91e-05	182	59	4	fc020d784ab81af80d9331cc322b7c259284eaef
ToppCell	droplet-Liver-Npc-21m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 STAB2 NRXN2 NR2F1	9.91e-05	182	59	4	b1ec2015aad1181eac1bbf8d48ad6f2f7ed24a01
ToppCell	COVID-19-kidney-PCT-S1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	FAT1 ASTN2 HNF4A HNF4G	1.01e-04	183	59	4	6878d14026c3df6aa12e45dfad94b32fa9d9b0b7
ToppCell	5'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating-Lymphatic_EC_differentiating_L.2.5.1.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SPRY1 STAB2 ITGA9 NR2F1	1.01e-04	183	59	4	4d16bfbadf2cd13008c35e23dd2b5b4ecf92ee11
ToppCell	PND14-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP2-CAP2_prolif\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ARHGEF10 CNDP2 DCBLD1 FAM124A	1.01e-04	183	59	4	3ef9ac1ae13b6172f9121ab1c129ecaa0fef460f
ToppCell	3'_v3-Lung-Myeloid_Dendritic-DC1\|Lung / Manually curated celltypes from each tissue	ZBTB46 ENPP1 CFI PGR	1.01e-04	183	59	4	e4cbd39575b5a4612d9934532e3bad63286f8aa5
Drug	CDRI-85/287	NR2C2 NR2F6 NR3C1 NR2F1 PGR	1.02e-08	29	58	5	CID000159508
Drug	DR-0	NR2C2 NR2F6 HNF4A HNF4G NR2F1	2.75e-08	35	58	5	CID010062716
Drug	Implanon	NR2C2 NR2F6 NR3C1 NR2F1 PGR	1.27e-07	47	58	5	CID000040976
Drug	sodium molybdate	NR2C2 NR2F6 NR3C1 NR2F1 PGR	3.40e-07	57	58	5	CID000061424
Drug	CV-1	TGFB1I1 NR2F6 NR3C1 HNF4A HNF4G NR2F1 PGR	1.14e-06	213	58	7	CID000130105
Drug	Megestrol	NR3C1 PGR	6.38e-06	2	58	2	DB00351
Drug	SureCN3012010	NR3C1 PGR	6.38e-06	2	58	2	CID009861044
Drug	CHEMBL227088	NR3C1 PGR	6.38e-06	2	58	2	CID009885493
Drug	SureCN3023194	NR3C1 PGR	6.38e-06	2	58	2	CID009905296
Drug	CHEMBL388997	NR3C1 PGR	6.38e-06	2	58	2	CID009842832
Drug	CHEMBL227783	NR3C1 PGR	6.38e-06	2	58	2	CID009841404
Drug	Mifepristone	NR3C1 PGR	6.38e-06	2	58	2	DB00834
Drug	E-guggulsterone	NR2C2 NR2F6 NR3C1 NR2F1 PGR	8.21e-06	108	58	5	CID006439929
Drug	AC1L2E0P	NR2F6 RORB NR3C1 HNF4A HNF4G NR2F1 PGR	1.26e-05	307	58	7	CID000019390
Drug	helioxanthin	AFP HNF4A HNF4G	1.73e-05	20	58	3	CID000177023
Drug	AC1L2TV3	NR3C1 PGR	1.91e-05	3	58	2	CID000128478
Drug	AC1L2TV6	NR3C1 PGR	1.91e-05	3	58	2	CID000128479
Drug	Alcohol, 8	NR3C1 PGR	1.91e-05	3	58	2	CID011213029
Drug	Methyl ether, 9	NR3C1 PGR	1.91e-05	3	58	2	CID011155441
Drug	RU 42698	NR3C1 PGR	1.91e-05	3	58	2	CID000128734
Drug	CDB-2914	NR3C1 PGR	1.91e-05	3	58	2	CID000130904
Drug	RU 45196	NR3C1 PGR	1.91e-05	3	58	2	CID000196767
Drug	4 GPa	ARG2 NR3C1	1.91e-05	3	58	2	CID003082328
Drug	Oxime, 22	NR3C1 PGR	1.91e-05	3	58	2	CID011282904
Drug	methyl methanethiosulfonate	NR3C1 PGR	1.91e-05	3	58	2	ctd:C014674
Drug	secondary alcohol, 15	NR3C1 PGR	1.91e-05	3	58	2	CID011752649
Drug	Loteprednol Etabonate	NR3C1 PGR	1.91e-05	3	58	2	ctd:D000069559
Drug	AC1L1M7Y	NR2E3 AFP NR3C1 PGR	2.73e-05	68	58	4	CID000057056
Drug	Fluticasone Propionate	NR3C1 PGR	3.81e-05	4	58	2	DB00588
Drug	laurolactam	NR3C1 PGR	3.81e-05	4	58	2	ctd:C474694
Drug	2,4,6-trimethylbenzaldehyde	NR3C1 PGR	3.81e-05	4	58	2	ctd:C526470
Drug	4-hydroxy-2',3',4'-5'-tetrachlorobiphenyl	AFP PGR	3.81e-05	4	58	2	ctd:C427824
Drug	1,6-hexanediol	ENPP1 NR3C1 PGR	3.91e-05	26	58	3	CID000012374
Drug	RU 16117	AFP NR3C1 PGR	4.91e-05	28	58	3	CID000066408
Drug	dihydroquinoline	NR3C1 PGR	6.35e-05	5	58	2	CID005231402
Drug	pH x	AFP HNF4A HNF4G	8.88e-05	34	58	3	CID011967789
Drug	3',5'-dichloro-2-hydroxy-2-methylbut-3-enanilide	NR3C1 PGR	9.50e-05	6	58	2	ctd:C101850
Drug	2,6-di-tert-butyl-4-hydroxy-4-methyl-2,5-cyclohexadien-1-one	NR3C1 PGR	9.50e-05	6	58	2	ctd:C038639
Drug	RU-43044	NR3C1 PGR	9.50e-05	6	58	2	CID000188913
Drug	3,5-di-tert-butyl-4-hydroxybenzaldehyde	NR3C1 PGR	9.50e-05	6	58	2	ctd:C513957
Drug	testosterone-3-carboxymethyloxime-bovine serum albumin conjugate	TGFB1I1 HSPG2 NR2C2 NR3C1 HNF4A	1.08e-04	185	58	5	ctd:C045037
Drug	rifampicin	NR2E3 POLR1A NR3C1 HNF4A HNF4G PGR	1.26e-04	306	58	6	CID005381226
Drug	Fluorometholone [426-13-1]; Up 200; 10.6uM; HL60; HT_HG-U133A	ARHGEF10 RERE CTNND2 ITGA9 NR2F1	1.32e-04	193	58	5	2509_UP
Drug	drotaverine HCl	DSPP NR3C1	1.33e-04	7	58	2	CID000026394
Drug	ethyl myristate	NR3C1 PGR	1.33e-04	7	58	2	ctd:C032396
Drug	2,3-DHP	CTTNBP2 RERE	1.33e-04	7	58	2	CID000000020
Drug	anthrax toxin	NR3C1 PGR	1.33e-04	7	58	2	ctd:C030325
Drug	AC1L1EST	ARG2 DSPP CNDP2	1.34e-04	39	58	3	CID000002932
Drug	Urapidil hydrochloride [64887-14-5]; Up 200; 9.4uM; HL60; HT_HG-U133A	HSPG2 STAB2 NRXN2 ENPP1 ASTN2	1.39e-04	195	58	5	3078_UP
Drug	AH23848 hemicalcium salt hydrate; Up 200; 1uM; MCF7; HT_HG-U133A	SPRY1 CELSR2 RORC RERE TGS1	1.39e-04	195	58	5	6903_UP
Drug	Trichlormethiazide [133-67-5]; Down 200; 10.6uM; PC3; HT_HG-U133A	CELSR2 ARHGEF10 DSPP ZNF480 ASTN2	1.39e-04	195	58	5	4198_DN
Drug	PNU-0230031 [267429-39-0]; Down 200; 10uM; PC3; HT_HG-U133A	NR2F6 NR2E3 SZT2 DSPP RERE	1.39e-04	195	58	5	3732_DN
Drug	Sulfacetamide sodic hydrate [6209-17-2]; Down 200; 15.8uM; MCF7; HT_HG-U133A	ARG2 NR2F6 NR3C1 CTNND2 TGS1	1.42e-04	196	58	5	1695_DN
Drug	(d,l)-Tetrahydroberberine [522-97-4]; Up 200; 11.8uM; MCF7; HT_HG-U133A	HSPG2 SPRY1 NR2E3 SZT2 RORC	1.46e-04	197	58	5	4138_UP
Drug	Thyroxine (L) [51-48-9]; Up 200; 5.2uM; MCF7; HT_HG-U133A	NR2E3 SZT2 ARHGEF10 RERE ITGA9	1.46e-04	197	58	5	4150_UP
Drug	Lysergol [602-85-7]; Down 200; 15.8uM; PC3; HT_HG-U133A	NR2C2 AKAP9 ASTN2 NR3C1 TGS1	1.46e-04	197	58	5	6621_DN
Drug	Josamycin [16846-24-5]; Down 200; 4.8uM; MCF7; HT_HG-U133A	TGFB1I1 NR2F6 ARHGEF10 ASTN2 PGR	1.46e-04	197	58	5	5692_DN
Drug	Corynanthine hydrochloride [66634-44-4]; Up 200; 10.2uM; MCF7; HT_HG-U133A	SPRY1 NR2E3 DSPP RERE NR3C1	1.49e-04	198	58	5	4811_UP
Drug	Levamisole hydrochloride [16595-80-5]; Down 200; 16.6uM; MCF7; HT_HG-U133A	ENPP1 LAMA3 RRP15 ZNF480 TGS1	1.49e-04	198	58	5	7450_DN
Drug	Phthalylsulfathiazole [85-73-4]; Up 200; 10uM; HL60; HT_HG-U133A	ARG2 SNED1 ARHGEF10 LAMA3 ITGA9	1.49e-04	198	58	5	3033_UP
Drug	Tiabendazole [148-79-8]; Down 200; 19.8uM; PC3; HT_HG-U133A	NR2F6 CELSR2 SZT2 ARHGEF10 TGS1	1.49e-04	198	58	5	4579_DN
Drug	Pentetic acid [67-43-6]; Down 200; 10.2uM; PC3; HT_HG-U133A	TGFB1I1 NR2F6 ARHGEF10 CTNND2 TGS1	1.49e-04	198	58	5	4669_DN
Drug	Karakoline [39089-30-0]; Down 200; 10.6uM; PC3; HT_HG-U133A	NR2F6 NR2E3 SZT2 ZNF480 CTNND2	1.53e-04	199	58	5	3741_DN
Drug	Arcaine sulfate [14923-17-2]; Down 200; 14.8uM; MCF7; HT_HG-U133A	HSPG2 NR2F6 NR2E3 ARHGEF10 NR3C1	1.53e-04	199	58	5	3349_DN
Drug	Mesalamine [89-57-6]; Up 200; 26.2uM; MCF7; HT_HG-U133A	HSPG2 SPRY1 NR2F6 RERE HNF4A	1.53e-04	199	58	5	7241_UP
Drug	Reductoleptomycin a	ARG2 ITGA9 PGR	1.56e-04	41	58	3	CID006448769
Drug	Aztreonam [78110-38-0]; Up 200; 9.2uM; MCF7; HT_HG-U133A	SPRY1 STAB2 RORC NR3C1 HNF4A	1.56e-04	200	58	5	5535_UP
Drug	factor T	NR3C1 HNF4A	1.77e-04	8	58	2	CID000452319
Drug	mespirenone	NR3C1 PGR	1.77e-04	8	58	2	CID000065660
Drug	NSC613665	NR2E3 FAT1 CNDP2	2.20e-04	46	58	3	CID003000649
Drug	2,3,2-tet	HNF4A HNF4G	2.27e-04	9	58	2	CID000078479
Drug	17-alpha-Hydroxyprogesterone	NR3C1 PGR	2.27e-04	9	58	2	ctd:D019326
Drug	sodium lauryl sarcosinate	AFP ENPP1	2.27e-04	9	58	2	CID000061426
Drug	AC1Q6CTU	NR2C2 POLR1A RORB NR2F1	2.34e-04	118	58	4	CID000021362
Drug	proligestone	NR3C1 PGR	2.83e-04	10	58	2	CID000071906
Drug	AC1LA234	NR3C1 PGR	2.83e-04	10	58	2	CID000480136
Drug	AC1Q6PCP	NR2C2 NR2F6 NR3C1 NR2F1 PGR	2.98e-04	230	58	5	CID000005267
Drug	aklavinone	CTTNBP2 DSPP	3.46e-04	11	58	2	CID000159776
Drug	DNBA	DSPP TGS1	3.46e-04	11	58	2	CID000007433
Drug	3,4,3',4'-tetrachloroazobenzene	NR3C1 PGR	3.46e-04	11	58	2	ctd:C013279
Drug	NSC123116	HNF4A HNF4G	3.46e-04	11	58	2	CID000275966
Drug	AC1L1CD2	NR3C1 PGR	3.46e-04	11	58	2	CID000027021
Drug	8-Bromo Cyclic Adenosine Monophosphate	TGFB1I1 CTTNBP2 AKAP9 LAMA3 RORB NR3C1 HNF4G PGR	3.54e-04	693	58	8	ctd:D015124
Disease	Endometrioma	NR2C2 NR2F6 ENPP1 RORB NR3C1 PGR	6.93e-07	161	57	6	C0269102
Disease	Endometriosis	NR2C2 NR2F6 ENPP1 RORB NR3C1 PGR	6.93e-07	161	57	6	C0014175
Disease	maturity-onset diabetes of the young type 1 (implicated_via_orthology)	HNF4A HNF4G	3.67e-06	2	57	2	DOID:0111099 (implicated_via_orthology)
Disease	triacylglycerol 48:0 measurement	C16orf82 RORB CTNND2	1.72e-05	26	57	3	EFO_0010403
Disease	Fanconi syndrome (implicated_via_orthology)	HNF4A HNF4G	2.19e-05	4	57	2	DOID:1062 (implicated_via_orthology)
Disease	3-methyl-2-oxovalerate measurement	MACROD2 ASTN2	3.65e-05	5	57	2	EFO_0021021
Disease	sleep efficiency	GOLGA8B GOLGA8A	3.65e-05	5	57	2	EFO_0803364
Disease	age at menarche	ZBTB46 INSM1 MACROD2 RORB RERE HNF4G NR2F1	1.43e-04	594	57	7	EFO_0004703
Disease	maturity-onset diabetes of the young (implicated_via_orthology)	HNF4A HNF4G	1.63e-04	10	57	2	DOID:0050524 (implicated_via_orthology)
Disease	serum gamma-glutamyl transferase measurement	ZBTB46 CELSR2 MACROD2 ASTN2 RORC ITGA9 HNF4A HNF4G	3.54e-04	914	57	8	EFO_0004532
Disease	thyroid peroxidase antibody measurement	CTTNBP2 RORB RERE	3.71e-04	72	57	3	EFO_0005666
Disease	osteoarthritis (implicated_via_orthology)	ENPP1 MATN3	3.79e-04	15	57	2	DOID:8398 (implicated_via_orthology)
Disease	major depressive disorder (is_implicated_in)	NR3C1 CTNND2	4.89e-04	17	57	2	DOID:1470 (is_implicated_in)
Disease	nephrotic syndrome (is_marker_for)	NR3C1 CFI	5.50e-04	18	57	2	DOID:1184 (is_marker_for)
Disease	osteochondrodysplasia (is_implicated_in)	HSPG2 MATN3	6.14e-04	19	57	2	DOID:2256 (is_implicated_in)
Disease	sucrose liking measurement	GOLGA8B GOLGA8A	6.81e-04	20	57	2	EFO_0010157
Disease	Multiple Epiphyseal Dysplasia	HSPG2 MATN3	6.81e-04	20	57	2	C0026760
Disease	obesity (is_implicated_in)	ENPP1 NR3C1 PGR	7.36e-04	91	57	3	DOID:9970 (is_implicated_in)
Disease	polycystic ovary syndrome (biomarker_via_orthology)	NR3C1 PGR	7.52e-04	21	57	2	DOID:11612 (biomarker_via_orthology)
Disease	neutrophil count, eosinophil count	USP50 RERE HNF4A TGS1	7.73e-04	213	57	4	EFO_0004833, EFO_0004842
Disease	type 2 diabetes mellitus (implicated_via_orthology)	NR2F6 NR3C1 NR2F1	1.11e-03	105	57	3	DOID:9352 (implicated_via_orthology)
Disease	TYPE 2 DIABETES MELLITUS	ENPP1 HNF4A	1.34e-03	28	57	2	125853
Disease	lung small cell carcinoma (is_implicated_in)	FAT1 LAMA3	1.34e-03	28	57	2	DOID:5409 (is_implicated_in)
Disease	Type 2 diabetes mellitus	ENPP1 HNF4A	1.34e-03	28	57	2	cv:C0011860
Disease	granulocyte count	USP50 RERE HNF4A TGS1	1.48e-03	254	57	4	EFO_0007987
Disease	putamen volume	HELZ CTNND2	1.64e-03	31	57	2	EFO_0006932
Disease	total cholesterol measurement, C-reactive protein measurement	CELSR2 HNF4A	1.64e-03	31	57	2	EFO_0004458, EFO_0004574
Disease	Uterine leiomyoma, breast carcinoma	ZBTB46 ASTN2	1.75e-03	32	57	2	EFO_0000305, HP_0000131
Disease	docosahexaenoic acid measurement	CELSR2 DSPP CTNND2	1.92e-03	127	57	3	EFO_0007761

Protein segments in the cluster

Peptide	Gene	Start	Entry
GAEKTDSFYHSSGGL	AKAP9	3806	Q99996
DAIEYGSSAGTGEHS	ARHGEF10	706	O15013
AGTYDGSIDACKGDS	CFI	511	P05156
AVSDGYSCVTLGGDH	ARG2	106	P78540
GFGKHTESGSDSECS	BRPF3	1001	Q9ULD4
GDTGKAETYGHDGIH	DSPP	111	Q9NZW4
DGYTGEHCEVSARSG	CELSR2	1316	Q9HCU4
ECTGSNATYHGAKGE	CTNND2	1091	Q9UQB3
LTCSDLHGIYEDGGK	ATG2A	696	Q2TAZ0
GSGCYDHSKGIDCSD	ASTN2	691	O75129
DHSKGIDCSDGFNGG	ASTN2	696	O75129
DKSSGKHYGVFTCEG	NR2F6	61	P10588
GDSSSGKHYGIYACN	NR2E3	51	Q9Y5X4
GDKASGRHYGAVSCE	NR2C2	121	P49116
ADSGEYVCHVVGTSG	HSPG2	2211	P98160
DKSSGKHYGQFTCEG	NR2F1	91	P10589
EDHCSLGSYGLKDGD	DDI1	56	Q8WTU0
GNYDSHFDVDKGTGT	FAT1	1396	Q14517
SDGEGKHHCECSQGY	MATN3	281	O15232
SHVGGDSCDTCEDGY	LAMA3	656	Q16787
GCGVYDGTEIHEASA	GATD3B	51	A0A0B4J2D5
GLKTADPHDCSAYTG	LANCL2	91	Q9NS86
DSGAETGGSDYSHLS	FAM124A	16	Q86V42
RATGKHYGASSCDGC	HNF4A	66	P41235
DESDYHCGADHGSGS	IGLV9-49	106	A0A0B4J1Y8
CSHTGFGGKFCSEEE	NRXN2	231	Q9P2S2
DEASGCHYGVLTCGS	NR3C1	426	P04150
ERKYCGSGFHGSDNV	ENPP1	526	P22413
SGYHVEDLDEGSCNG	HELZ	151	P42694
GDRATGKHYGASSCD	HNF4G	16	Q14541
GDEASGCHYGVLTCG	PGR	571	P06401
KYGEEHGSCQAGIAG	ITGA9	186	Q13797
CEDGHSALYSAAKNG	CTTNBP2	741	Q8WZ74
GCGVYDGTEIHEASA	GATD3	51	P0DPI2
AGDGVAACGSYSEGH	GOLGA8B	491	A8MQT2
AACGSYSEGHGKFLA	GOLGA8B	496	A8MQT2
EEAGVSTDAGGHYDC	DCBLD1	566	Q8N8Z6
EKYGHSDCCSQSEEG	AFP	106	P02771
GVSESGSEDGLYECH	INSM1	356	Q01101
NGCDTGHAKITCGYD	MACROD2	121	A1Z1Q3
DGVAACGSYSEGHGK	GOLGA8A	521	A7E2F4
CGSYSEGHGKFLAAA	GOLGA8A	526	A7E2F4
YKVSSHGGDSGLDGL	PYGO1	11	Q9Y3Y4
SVDSDHLGYDGGSSG	SZT2	1861	Q5T011
CGVLDKAHYGSSAYG	POLR1A	746	O95602
YGDCDNYATLKGHSG	SNRNP40	96	Q96DI7
CTLEGGAKNYAESDH	RERE	41	Q9P2R6
NGGTCKEAGGEYHCS	SNED1	591	Q8TER0
ECSNKDLHSGVYGGS	CNDP2	221	Q96KP4
DKSSGIHYGVITCEG	RORC	36	P51449
KDSDAFGGYGRSCLH	ZNF577	106	Q9BSK1
DKSSGIHYGVITCEG	RORB	26	Q92753
QKGYKGDGHSCTEID	STAB2	2111	Q8WWQ8
KGIFYHCSNDDEGDS	SPRY1	226	O43609
GDLDGGHYTAFCKNS	USP50	321	Q70EL3
EGSCGSEKDHFYSDD	RRP15	46	Q9Y3B9
ECGKAFSEYSGLSAH	ZNF480	431	Q8WV37
VAEFDSHSGGSYCKL	ZBTB49	641	Q6ZSB9
SGESSGASGDKDHLY	TGFB1I1	46	O43294
GYSCGTAESHDSKGI	TGS1	66	Q96RS0
SHASLSSGYAGDKEG	C16orf82	146	Q7Z2V1
IASCHDGGSSYGKED	ZBTB46	186	Q86UZ6
YGCEECGKSFSSEGH	ZNF814	436	B7Z6K7