Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	response to osmotic stress	LRRC8E LRRC8C ICOSLG MKNK1 RPTOR VPS13A NLK	2.46e-06	113	110	7	GO:0006970
GeneOntologyBiologicalProcess	cellular response to osmotic stress	LRRC8E LRRC8C RPTOR VPS13A NLK	4.15e-05	72	110	5	GO:0071470
GeneOntologyCellularComponent	Cul4-RING E3 ubiquitin ligase complex	DCAF1 DCAF12L2 DCAF12L1 DCAF12 WDTC1	1.76e-06	38	112	5	GO:0080008
Domain	Pumilio_RNA-bd	PUM2 PUM1	3.37e-05	2	109	2	IPR033712
Domain	PUF	PUM2 PUM1	1.01e-04	3	109	2	PF00806
Domain	PUM_HD	PUM2 PUM1	1.01e-04	3	109	2	PS50303
Domain	PUM-HD	PUM2 PUM1	1.01e-04	3	109	2	IPR033133
Domain	Fumarylacetoacetase_C-rel	FAHD2B FAHD2A	2.01e-04	4	109	2	IPR011234
Domain	FAA_hydrolase	FAHD2B FAHD2A	2.01e-04	4	109	2	PF01557
Domain	-	FAHD2B FAHD2A	2.01e-04	4	109	2	3.90.850.10
Domain	SHR-BD	VPS13A VPS13B	2.01e-04	4	109	2	IPR009543
Domain	PUM	PUM2 PUM1	2.01e-04	4	109	2	PS50302
Domain	Pumilio_RNA-bd_rpt	PUM2 PUM1	2.01e-04	4	109	2	IPR001313
Domain	VPS13_C	VPS13A VPS13B	2.01e-04	4	109	2	PF16909
Domain	VPS13_C	VPS13A VPS13B	2.01e-04	4	109	2	IPR031645
Domain	Pumilio	PUM2 PUM1	2.01e-04	4	109	2	SM00025
Domain	SHR-BD	VPS13A VPS13B	2.01e-04	4	109	2	PF06650
Domain	LRRC8_Pannexin-like	LRRC8E LRRC8C	3.34e-04	5	109	2	IPR021040
Domain	Autophagy-rel_C	VPS13A VPS13B	3.34e-04	5	109	2	IPR015412
Domain	ATG_C	VPS13A VPS13B	3.34e-04	5	109	2	PF09333
Domain	Pannexin_like	LRRC8E LRRC8C	3.34e-04	5	109	2	PF12534
Domain	Znf_MYM	ZMYM2 ZMYM5	6.95e-04	7	109	2	IPR010507
Domain	ZnF_UBR1	UBR1 UBR4	6.95e-04	7	109	2	SM00396
Domain	ZF_UBR	UBR1 UBR4	6.95e-04	7	109	2	PS51157
Domain	zf-UBR	UBR1 UBR4	6.95e-04	7	109	2	PF02207
Domain	Znf_UBR	UBR1 UBR4	6.95e-04	7	109	2	IPR003126
Domain	zf-FCS	ZMYM2 ZMYM5	6.95e-04	7	109	2	PF06467
Domain	TRASH_dom	ZMYM2 ZMYM5	9.24e-04	8	109	2	IPR011017
Domain	TRASH	ZMYM2 ZMYM5	9.24e-04	8	109	2	SM00746
Domain	Chorein_N	VPS13A VPS13B	9.24e-04	8	109	2	PF12624
Domain	VPS13_N	VPS13A VPS13B	9.24e-04	8	109	2	IPR026854
Domain	ARM-like	DCAF1 SETX PUM2 RPTOR ANKAR HEATR9 PUM1	1.04e-03	270	109	7	IPR011989
Domain	E3_UB_ligase_RBR	RNF217 RNF14	1.47e-03	10	109	2	IPR031127
Domain	WD40_repeat_dom	DCAF1 UBR4 DCAF12L2 DCAF12L1 RPTOR DCAF12 WDTC1	1.79e-03	297	109	7	IPR017986
Domain	-	DCAF1 PUM2 RPTOR ANKAR HEATR9 PUM1	1.93e-03	222	109	6	1.25.10.10
Domain	IBR	RNF217 RNF14	2.93e-03	14	109	2	PF01485
Domain	IBR	RNF217 RNF14	2.93e-03	14	109	2	SM00647
Domain	IBR_dom	RNF217 RNF14	3.37e-03	15	109	2	IPR002867
Domain	ARM-type_fold	DCAF1 UBR4 PUM2 RPTOR ANKAR HEATR9 PUM1	3.74e-03	339	109	7	IPR016024
Domain	Integrin_alpha_C_CS	ITGA1 ITGAV	3.84e-03	16	109	2	IPR018184
Domain	Integrin_alpha-2	ITGA1 ITGAV	4.86e-03	18	109	2	IPR013649
Domain	LH2	PKD1L2 LOXHD1	4.86e-03	18	109	2	SM00308
Domain	INTEGRIN_ALPHA	ITGA1 ITGAV	4.86e-03	18	109	2	PS00242
Domain	Integrin_alpha2	ITGA1 ITGAV	4.86e-03	18	109	2	PF08441
Domain	Integrin_alpha	ITGA1 ITGAV	4.86e-03	18	109	2	IPR000413
Domain	Int_alpha	ITGA1 ITGAV	5.41e-03	19	109	2	SM00191
Domain	Int_alpha_beta-p	ITGA1 ITGAV	5.41e-03	19	109	2	IPR013519
Domain	WD_REPEATS_1	DCAF1 DCAF12L2 DCAF12L1 RPTOR DCAF12 WDTC1	5.81e-03	278	109	6	PS00678
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	DCAF1 UBR1 AARS1 SETX RASA2 L3MBTL2 PDLIM7 MTHFD1L UBR4 SUCLG2 ARAP3 SLC16A1 WASHC5 ABCE1 FANCI RPTOR ZNF638 ACAA2 EXOC2 ALDH9A1 PUM1	2.43e-09	1353	113	21	29467282
Pubmed	A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1.	DCAF1 DCAF12L2 DCAF12L1 DCAF12 WDTC1	1.33e-07	37	113	5	16949367
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	EEFSEC UBR1 AARS1 PDE3B SETX ANKRD50 ADCY6 ARAP3 WASHC5 ABCE1 DSTYK ZNF638	1.46e-06	650	113	12	38777146
Pubmed	Human immunodeficiency virus type 1 Vpr links proteasomal degradation and checkpoint activation.	DCAF1 UBR1 UBR4	2.77e-06	9	113	3	17855541
Pubmed	ZDHHC11 and ZDHHC11B are critical novel components of the oncogenic MYC-miR-150-MYB network in Burkitt lymphoma.	ZDHHC11B ZDHHC11	1.05e-05	2	113	2	28331227
Pubmed	Differential expression of murine CGI-105 gene in 3T3-L1 cells by adrenocorticotropic hormones.	FAHD2B FAHD2A	1.05e-05	2	113	2	15774318
Pubmed	Cloning and comparative sequence analysis of PUM1 and PUM2 genes, human members of the Pumilio family of RNA-binding proteins.	PUM2 PUM1	1.05e-05	2	113	2	12459267
Pubmed	Identification of diverse target RNAs that are functionally regulated by human Pumilio proteins.	PUM2 PUM1	1.05e-05	2	113	2	29165587
Pubmed	PUMILIO-mediated translational control of somatic cell cycle program promotes folliculogenesis and contributes to ovarian cancer progression.	PUM2 PUM1	1.05e-05	2	113	2	35507203
Pubmed	Bespoke RNA recognition by Pumilios.	PUM2 PUM1	1.05e-05	2	113	2	26517885
Pubmed	Mouse Pum1 and Pum2 genes, members of the Pumilio family of RNA-binding proteins, show differential expression in fetal and adult hematopoietic stem cells and progenitors.	PUM2 PUM1	1.05e-05	2	113	2	12667987
Pubmed	Genome-wide comparison of human keratinocyte and squamous cell carcinoma responses to UVB irradiation: implications for skin and epithelial cancer.	PUM2 PUM1	1.05e-05	2	113	2	12771951
Pubmed	Alternate modes of cognate RNA recognition by human PUMILIO proteins.	PUM2 PUM1	1.05e-05	2	113	2	21397187
Pubmed	A Quantitative and Predictive Model for RNA Binding by Human Pumilio Proteins.	PUM2 PUM1	1.05e-05	2	113	2	31078383
Pubmed	Principles of mRNA control by human PUM proteins elucidated from multimodal experiments and integrative data analysis.	PUM2 PUM1	1.05e-05	2	113	2	32753408
Pubmed	PUMILIO proteins promote colorectal cancer growth via suppressing p21.	PUM2 PUM1	1.05e-05	2	113	2	35338151
Pubmed	Effects of PUMILIO1 and PUMILIO2 knockdown on cardiomyogenic differentiation of human embryonic stem cells culture.	PUM2 PUM1	1.05e-05	2	113	2	32437472
Pubmed	Comparative analysis of mRNA targets for human PUF-family proteins suggests extensive interaction with the miRNA regulatory system.	PUM2 PUM1	1.05e-05	2	113	2	18776931
Pubmed	Phosphodiesterase 2A and 3B variants are associated with primary aldosteronism.	PDE2A PDE3B	1.05e-05	2	113	2	33112806
Pubmed	Characterization of RNP Networks of PUM1 and PUM2 Post-Transcriptional Regulators in TCam-2 Cells, a Human Male Germ Cell Model.	PUM2 PUM1	1.05e-05	2	113	2	32316190
Pubmed	Testis-specific hnRNP is expressed in colorectal cancer cells and accelerates cell growth mediating ZDHHC11 mRNA stabilization.	ZDHHC11B ZDHHC11	1.05e-05	2	113	2	35384384
Pubmed	Defining the membrane proteome of NK cells.	PIGN LRRC8C AARS1 PDE3B MTHFD1L UBR4 ITGA1 MAGT1 SLC16A1 ABCE1 FANCI PARP9 ATP13A3 EXOC2	2.67e-05	1168	113	14	19946888
Pubmed	Antagonistic and cooperative AGO2-PUM interactions in regulating mRNAs.	PUM2 PUM1	3.13e-05	3	113	2	30333515
Pubmed	Human Pumilio proteins directly bind the CCR4-NOT deadenylase complex to regulate the transcriptome.	PUM2 PUM1	3.13e-05	3	113	2	33397688
Pubmed	NORAD: Defender of the Genome.	PUM2 PUM1	3.13e-05	3	113	2	27157388
Pubmed	A novel function of human Pumilio proteins in cytoplasmic sensing of viral infection.	PUM2 PUM1	3.13e-05	3	113	2	25340845
Pubmed	PUMILIO/FOXP1 signaling drives expansion of hematopoietic stem/progenitor and leukemia cells.	PUM2 PUM1	3.13e-05	3	113	2	28232582
Pubmed	ZDHHC19 localizes to the cell membrane of spermatids and is involved in spermatogenesis†.	ZDHHC11B ZDHHC11	3.13e-05	3	113	2	34897408
Pubmed	Noncoding RNA NORAD Regulates Genomic Stability by Sequestering PUMILIO Proteins.	PUM2 PUM1	3.13e-05	3	113	2	26724866
Pubmed	A universal metabolite repair enzyme removes a strong inhibitor of the TCA cycle.	FAHD2B FAHD2A	3.13e-05	3	113	2	38287013
Pubmed	COP9 signalosome component CSN-5 stabilizes PUF proteins FBF-1 and FBF-2 in Caenorhabditis elegans germline stem and progenitor cells.	PUM2 PUM1	3.13e-05	3	113	2	38427913
Pubmed	Pumilio facilitates miRNA regulation of the E2F3 oncogene.	PUM2 PUM1	3.13e-05	3	113	2	22345517
Pubmed	Specification of SUMO1- and SUMO2-interacting motifs.	SETX ZMYM2 ZMYM5	4.92e-05	22	113	3	16524884
Pubmed	Mammalian Pum1 and Pum2 Control Body Size via Translational Regulation of the Cell Cycle Inhibitor Cdkn1b.	PUM2 PUM1	6.25e-05	4	113	2	30811992
Pubmed	Structural basis of FANCD2 deubiquitination by USP1-UAF1.	FANCI USP1	6.25e-05	4	113	2	33795880
Pubmed	Genome-wide association study of theta band event-related oscillations identifies serotonin receptor gene HTR7 influencing risk of alcohol dependence.	HTR7 ARID5A	6.25e-05	4	113	2	21184583
Pubmed	Analysis of the human VPS13 gene family.	VPS13A VPS13B	6.25e-05	4	113	2	15498460
Pubmed	LRRC8 Proteins Form Volume-Regulated Anion Channels that Sense Ionic Strength.	LRRC8E LRRC8C	6.25e-05	4	113	2	26824658
Pubmed	A family of mammalian E3 ubiquitin ligases that contain the UBR box motif and recognize N-degrons.	UBR1 UBR4	6.25e-05	4	113	2	16055722
Pubmed	ZDHHC11 modulates innate immune response to DNA virus by mediating MITA-IRF3 association.	ZDHHC11B ZDHHC11	6.25e-05	4	113	2	29429998
Pubmed	The substrate recognition domains of the N-end rule pathway.	UBR1 UBR4	6.25e-05	4	113	2	19008229
Pubmed	P21-activated kinase 4 interacts with integrin alpha v beta 5 and regulates alpha v beta 5-mediated cell migration.	ZBTB17 ITGAV	6.25e-05	4	113	2	12356872
Pubmed	Target RNA motif and target mRNAs of the Quaking STAR protein.	PUM2 PUM1	6.25e-05	4	113	2	16041388
Pubmed	LRRC8A:C/E Heteromeric Channels Are Ubiquitous Transporters of cGAMP.	LRRC8E LRRC8C	6.25e-05	4	113	2	33171122
Pubmed	Renal Deletion of LRRC8/VRAC Channels Induces Proximal Tubulopathy.	LRRC8E LRRC8C	1.04e-04	5	113	2	35777784
Pubmed	Structural and biochemical basis of interdependent FANCI-FANCD2 ubiquitination.	FANCI USP1	1.04e-04	5	113	2	36385258
Pubmed	An Important Role of Pumilio 1 in Regulating the Development of the Mammalian Female Germline.	PUM2 PUM1	1.04e-04	5	113	2	27170441
Pubmed	LRRC8 involved in B cell development belongs to a novel family of leucine-rich repeat proteins.	LRRC8E LRRC8C	1.04e-04	5	113	2	15094057
Pubmed	Identification of LRRC8 heteromers as an essential component of the volume-regulated anion channel VRAC.	LRRC8E LRRC8C	1.04e-04	5	113	2	24790029
Pubmed	PUM1 and PUM2 exhibit different modes of regulation for SIAH1 that involve cooperativity with NANOS paralogues.	PUM2 PUM1	1.04e-04	5	113	2	30269240
Pubmed	Genetic Associations with Gestational Duration and Spontaneous Preterm Birth.	EEFSEC AGTR2	1.04e-04	5	113	2	28877031
Pubmed	METTL3 protects METTL14 from STUB1-mediated degradation to maintain m6 A homeostasis.	UBR1 PDLIM7 MTHFD1L PUM2 SLC16A1 ABCE1	1.12e-04	231	113	6	36597993
Pubmed	Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.	UBR1 AARS1 PDLIM7 MTHFD1L UBR4 BDH2 PSME1 MAGT1 SUCLG2 SLC16A1 WASHC5 ABCE1 PARP9 UBE2E3	1.43e-04	1367	113	14	32687490
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	L3MBTL2 PDLIM7 ANKRD50 MKNK1 ARAP3 WASHC5 DNAJA4 ABCE1 RPTOR PUM1 GAREM1 WDTC1	1.46e-04	1038	113	12	26673895
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	LRRC8E DCAF1 PDLIM7 ZMYM2 ACVR1 MAGT1 ITGAV SLC16A1 WASHC5 FANCI RPTOR CD70 NLK	1.49e-04	1203	113	13	29180619
Pubmed	Intestinal epithelial cell-derived semaphorin 7A negatively regulates development of colitis via αvβ1 integrin.	ITGA1 ITGAV	1.56e-04	6	113	2	22198947
Pubmed	The RNA-binding protein Musashi-1 is produced in the developing and adult mouse eye.	PUM2 PUM1	1.56e-04	6	113	2	17768378
Pubmed	FANCI is a negative regulator of Akt activation.	FANCI USP1	1.56e-04	6	113	2	27097374
Pubmed	Differential functions of FANCI and FANCD2 ubiquitination stabilize ID2 complex on DNA.	FANCI USP1	1.56e-04	6	113	2	32510829
Pubmed	Promotion of RAD51-Mediated Homologous DNA Pairing by the RAD51AP1-UAF1 Complex.	FANCI USP1	1.56e-04	6	113	2	27239033
Pubmed	Pumilio proteins utilize distinct regulatory mechanisms to achieve complementary functions required for pluripotency and embryogenesis.	PUM2 PUM1	1.56e-04	6	113	2	32198202
Pubmed	ZDHHC11 Positively Regulates NF-κB Activation by Enhancing TRAF6 Oligomerization.	ZDHHC11B ZDHHC11	1.56e-04	6	113	2	34490261
Pubmed	N-Terminally extended human ubiquitin-conjugating enzymes (E2s) mediate the ubiquitination of RING-finger proteins, ARA54 and RNF8.	RNF14 UBE2E3	1.56e-04	6	113	2	11322894
Pubmed	The integrin beta 1 subunit associates with the vitronectin receptor alpha v subunit to form a novel vitronectin receptor in a human embryonic kidney cell line.	ITGA1 ITGAV	1.56e-04	6	113	2	1690718
Pubmed	Staufen 1 is expressed by neural precursor cells in the developing murine cortex but is dispensable for NPC self-renewal and neuronal differentiation in vitro.	PUM2 PUM1	2.17e-04	7	113	2	34678304
Pubmed	Ancient ubiquitous protein 1 binds to the conserved membrane-proximal sequence of the cytoplasmic tail of the integrin alpha subunits that plays a crucial role in the inside-out signaling of alpha IIbbeta 3.	ITGA1 ITGAV	2.17e-04	7	113	2	12042322
Pubmed	The N-terminal cysteine is a dual sensor of oxygen and oxidative stress.	UBR1 UBR4	2.17e-04	7	113	2	34893540
Pubmed	Specificity for deubiquitination of monoubiquitinated FANCD2 is driven by the N-terminus of USP1.	FANCI USP1	2.17e-04	7	113	2	30456385
Pubmed	NLK phosphorylates Raptor to mediate stress-induced mTORC1 inhibition.	RPTOR NLK	2.17e-04	7	113	2	26588989
Pubmed	Post-transcriptional gene expression control by NANOS is up-regulated and functionally important in pRb-deficient cells.	PUM2 PUM1	2.17e-04	7	113	2	25100735
Pubmed	In silico screening for palmitoyl substrates reveals a role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin palmitoylation in its targeting to Rab5-positive endosomes.	ZDHHC11B ZDHHC11	2.17e-04	7	113	2	23687301
Pubmed	A UAF1-containing multisubunit protein complex regulates the Fanconi anemia pathway.	FANCI USP1	2.17e-04	7	113	2	18082604
Pubmed	A genome-wide association study identifies novel alleles associated with hair color and skin pigmentation.	SLC24A4 EXOC2	2.89e-04	8	113	2	18483556
Pubmed	Knockout and knockin of the beta1 exon D define distinct roles for integrin splice variants in heart function and embryonic development.	ITGA1 ITGAV	2.89e-04	8	113	2	9553049
Pubmed	Expression of beta 1 integrin complexes on the surface of unfertilized mouse oocyte.	ITGA1 ITGAV	2.89e-04	8	113	2	7691492
Pubmed	GWAS of dental caries patterns in the permanent dentition.	ATXN7L1 PHTF2 EXOC2	3.25e-04	41	113	3	23064961
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	DCAF1 AARS1 MTHFD1L UBR4 ANKRD50 PTPN5 ARAP3 ABCE1 FANCI ALDH9A1 PADI2	3.40e-04	974	113	11	28675297
Pubmed	Host E3 ligase HUWE1 attenuates the proapoptotic activity of the MERS-CoV accessory protein ORF3 by promoting its ubiquitin-dependent degradation.	AARS1 MTHFD1L UBR4 MAGT1 SUCLG2 ABCE1 FANCI PUM1	3.67e-04	534	113	8	35032548
Pubmed	Characterization of integrin engagement during defined human embryonic stem cell culture.	ITGA1 ITGAV	3.71e-04	9	113	2	19933311
Pubmed	Sertoli cell PUMILIO proteins modulate mouse testis size through translational control of cell cycle regulators.	PUM2 PUM1	3.71e-04	9	113	2	35678316
Pubmed	Integrin recognition of different cell-binding fragments of laminin (P1, E3, E8) and evidence that alpha 6 beta 1 but not alpha 6 beta 4 functions as a major receptor for fragment E8.	ITGA1 ITGAV	3.71e-04	9	113	2	1693624
Pubmed	Mulan E3 ubiquitin ligase interacts with multiple E2 conjugating enzymes and participates in mitophagy by recruiting GABARAP.	RNF14 UBE2E3	3.71e-04	9	113	2	25224329
Pubmed	A promiscuous alpha-helical motif anchors viral hijackers and substrate receptors to the CUL4-DDB1 ubiquitin ligase machinery.	DCAF12 WDTC1	3.71e-04	9	113	2	19966799
Pubmed	Phospho-tyrosine dependent protein-protein interaction network.	VPS39 ANKRD50 ARID5A CCM2 ARAP3 DCAF12L1 GAREM1	3.98e-04	410	113	7	25814554
Pubmed	Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma.	ARAP3 EXOC2	4.63e-04	10	113	2	25261932
Pubmed	Genetic determinants of hair, eye and skin pigmentation in Europeans.	SLC24A4 EXOC2	4.63e-04	10	113	2	17952075
Pubmed	The mammalian TRIM-NHL protein TRIM71/LIN-41 is a repressor of mRNA function.	PUM2 PUM1	4.63e-04	10	113	2	23125361
Pubmed	Cellular functions of long noncoding RNAs.	PUM2 PUM1	4.63e-04	10	113	2	31048766
Pubmed	PIKES Analysis Reveals Response to Degraders and Key Regulatory Mechanisms of the CRL4 Network.	DCAF1 DCAF12 WDTC1	5.52e-04	49	113	3	31973889
Pubmed	Unraveling the Spatiotemporal Distribution of VPS13A in the Mouse Brain.	CHAT VPS13A	5.65e-04	11	113	2	34884823
Pubmed	Integrin repertoire on myogenic cells changes during the course of primary myogenesis in the mouse.	ITGA1 ITGAV	5.65e-04	11	113	2	15739233
Pubmed	Comparative interactome analysis of α-arrestin families in human and Drosophila.	DCAF1 VPS39 UBR4 ZMYM2 FANCI ZNF638	5.71e-04	313	113	6	38270169
Pubmed	HELQ promotes RAD51 paralogue-dependent repair to avert germ cell loss and tumorigenesis.	FANCI USP1	6.76e-04	12	113	2	24005329
Pubmed	Transfer of cGAMP into Bystander Cells via LRRC8 Volume-Regulated Anion Channels Augments STING-Mediated Interferon Responses and Anti-viral Immunity.	LRRC8E LRRC8C	6.76e-04	12	113	2	32277911
Pubmed	HIV-1 Vpr function is mediated by interaction with the damage-specific DNA-binding protein DDB1.	UBR1 UBR4	6.76e-04	12	113	2	17360488
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	LRRC8C PDE3B SETX UBR4 LOXHD1 ABCE1 AGTR2 SCN8A VPS13A	6.85e-04	736	113	9	29676528
Pubmed	Mouse screen reveals multiple new genes underlying mouse and human hearing loss.	FAHD2B L3MBTL2 MTHFD1L BDH2 FAHD2A PHTF2 ELL2 FANCI PUS10 AGTR2 VPS13A WDTC1	7.31e-04	1242	113	12	30973865
Pubmed	Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.	LRRC8E LRRC8C L3MBTL2 VPS39 PHTF2 ZMYM2 MAGT1 TSPAN14 USP1	7.82e-04	750	113	9	11230166
Pubmed	mTORC1 phosphorylates UVRAG to negatively regulate autophagosome and endosome maturation.	VPS39 RPTOR	7.97e-04	13	113	2	25533187
Pubmed	Mechanism of Ubiquitination and Deubiquitination in the Fanconi Anemia Pathway.	FANCI USP1	7.97e-04	13	113	2	27986371
Cytoband	4q31	ABCE1 PCDH18	2.67e-04	10	113	2	4q31
Cytoband	1p36.13	ZBTB17 UBR4 PADI2	3.66e-04	56	113	3	1p36.13
Cytoband	2q11.2	FAHD2B FAHD2A ARID5A	7.65e-04	72	113	3	2q11.2
GeneFamily	WD repeat domain containing\|DDB1 and CUL4 associated factors	DCAF1 DCAF12 WDTC1	8.05e-05	18	86	3	498
GeneFamily	Volume regulated anion channel subunits	LRRC8E LRRC8C	2.22e-04	5	86	2	1158
GeneFamily	Zinc fingers MYM-type	ZMYM2 ZMYM5	3.31e-04	6	86	2	86
GeneFamily	Ubiquitin protein ligase E3 component n-recognins	UBR1 UBR4	4.62e-04	7	86	2	785
GeneFamily	X-linked mental retardation\|Angiotensin receptors	ZNF674 MAGT1 AGTR2	2.05e-03	53	86	3	103
GeneFamily	CD molecules\|Integrin alpha subunits	ITGA1 ITGAV	3.26e-03	18	86	2	1160
GeneFamily	Zinc fingers DHHC-type\|Ankyrin repeat domain containing	ZDHHC11B ZDHHC11	5.77e-03	24	86	2	76
GeneFamily	Phosphodiesterases	PDE2A PDE3B	5.77e-03	24	86	2	681
GeneFamily	Ankyrin repeat domain containing	ANKRD62 ANKRD50 ARAP3 ANKAR ANKRD7	5.96e-03	242	86	5	403
Coexpression	GSE5589_IL6_KO_VS_IL10_KO_LPS_AND_IL10_STIM_MACROPHAGE_45MIN_DN	UBR1 PDE3B SUCLG2 ITGAV ACAA2 ATP13A3 ALDH9A1	2.56e-05	199	113	7	M6660
Coexpression	GSE3994_WT_VS_PAC1_KO_ACTIVATED_MAST_CELL_DN	ZBTB17 VPS39 ARID5A RND3 CACNA2D4 DNAJA4 VPS13B	2.64e-05	200	113	7	M6372
Coexpression	GSE28237_FOLLICULAR_VS_EARLY_GC_BCELL_DN	AARS1 PDE3B HTR7 MTHFD1L SUCLG2 CCM2 DCAF12L1	2.64e-05	200	113	7	M4885
Disease	Cohen syndrome (implicated_via_orthology)	VPS13A VPS13B	4.05e-05	3	109	2	DOID:0111590 (implicated_via_orthology)
Disease	calcium measurement	ATXN7L1 PHTF2 ZMYM2 RNF217 PUS10 HFM1 PARP9 POLK ZMYM5 EPHA1	1.14e-04	628	109	10	EFO_0004838
Disease	alcohol use disorder measurement, longitudinal alcohol consumption measurement	ZMYM2 SCN8A ZMYM5	3.48e-04	37	109	3	EFO_0007645, EFO_0009458
Disease	cerebellar ataxia (implicated_via_orthology)	AARS1 VPS13A	3.73e-04	8	109	2	DOID:0050753 (implicated_via_orthology)
Disease	uric acid measurement	PIGN LRRC8C ACVR1 ANKRD50 DCAF12L2 CCM2 HFM1 MINDY4 GAREM1	4.43e-04	610	109	9	EFO_0004761
Disease	3-methyl-2-oxobutyrate measurement	ANKRD50 NLK	5.97e-04	10	109	2	EFO_0021020
Disease	level of Phosphatidylinositol (18:1_18:1) in blood serum	ACAA2 USP1	1.03e-03	13	109	2	OBA_2045159
Disease	diffuse large B-cell lymphoma	ARAP3 EXOC2	1.20e-03	14	109	2	EFO_0000403
Disease	triacylglycerol 50:5 measurement	LRRC8E CACNA2D4	1.57e-03	16	109	2	EFO_0010412
Disease	level of Phosphatidylinositol (18:0_18:1) in blood serum	RND3 ACAA2	1.99e-03	18	109	2	OBA_2045155
Disease	hair colour measurement	ZBTB17 RASA2 ATXN7L1 PUM2 SLC24A4 DSTYK EXOC2 DCAF12	2.05e-03	615	109	8	EFO_0007822
Disease	superior temporal gyrus volume measurement	RNF14 ANKRD7	2.22e-03	19	109	2	EFO_0010331
Disease	mean corpuscular hemoglobin concentration	PCDHGA5 SUCLG2 ELL2 VPS13A ZNF638 HFM1 PARP9 EXOC2 USP1 VPS13B DCAF12	2.61e-03	1105	109	11	EFO_0004528
Disease	level of Phosphatidylinositol (18:0_20:4) in blood serum	ACAA2 USP1	3.25e-03	23	109	2	OBA_2045158
Disease	response to radiation, Hematuria	SLCO2A1 CD70	3.25e-03	23	109	2	GO_0009314, HP_0000790

Protein segments in the cluster

Peptide	Gene	Start	Entry
LVNQNLCCKVSDFGL	EPHA1	756	P21709
QVCCNGTRVFVQKEI	ALDH9A1	286	P49189
QVSKVEALQCQEEGC	ARID5A	266	Q03989
QLNCLGFIQDKITVC	ELL2	111	O00472
AVNLGVVICKQCAGQ	ARAP3	516	Q8WWN8
ANVLLFLCTNVIGIC	ADCY6	291	O43306
INICGQLNLVCFDKT	ATP13A3	486	Q9H7F0
NILVKKNGQCCIADL	ACVR1	341	Q04771
VNIVVVTLFCCQKGP	AGTR2	61	P50052
KAVQCQEEVCASILL	ANKRD62	111	A6NC57
AEELCCLLGQVFQVV	CCM2	206	Q9BSQ5
TKVVNCLIGCGANIN	ANKRD50	591	Q9ULJ7
VQQIQTVCIECKGQG	DNAJA4	171	Q8WW22
IQLVADGCCNLQKQI	MTHFD1L	771	Q6UB35
DGCCNLQKQIQITQL	MTHFD1L	776	Q6UB35
VICLVVCIQRFAQAQ	CD70	31	P32970
VCSACNQVVKPQVFQ	ATXN7L1	101	Q9ULK2
QQVGFVCAVLALVCC	SLC24A4	21	Q8NFF2
NGTVCQQLVVHIKAC	RASA2	166	Q15283
IAKQIPQVVEACCQF	ARHGAP36	231	Q6ZRI8
CAQSPLCVVNFNILV	PCDHGA5	96	Q9Y5G8
KCIECVQPQSLQFII	PUM2	856	Q8TB72
ICCQQLRQEGVVDIL	PTPN5	511	P54829
LCEVLQNKFGCISTL	PARP9	81	Q8IXQ6
QLCQKNLNCSIEFDV	PCDH18	96	Q9HCL0
VSIICQLCNANFKVN	ANKAR	546	Q7Z5J8
CCIQLVESGDLQKEI	FANCI	71	Q9NVI1
CNTVQQLYVCIGVIG	SLC16A1	106	P53985
EIQKSALQIIINCVC	DCAF1	676	Q9Y4B6
QCVVCKQADEEFQIL	MAGT1	86	Q9H0U3
NLGNICVATVCKVLL	L3MBTL2	441	Q969R5
CEKVVILCPFTGIQQ	LOXHD1	376	Q8IVV2
VVCGTKCNTLFVVDV	DCAF12L2	111	Q5VW00
FEQCIVCSLQSLKGV	EXOC2	621	Q96KP1
CECQALLQVAKNLFT	PDE2A	391	O00408
LLVCQVCIKLADING	PDE3B	926	Q13370
IQTKTVVVCCVLRNN	GAREM1	276	Q9H706
LCQAQEVICTGKQLT	LRRC52	31	Q8N7C0
HNLKICCRVNGEVVQ	FAHD2A	231	Q96GK7
FGCTLQVTQDKIICL	LRRC8E	41	Q6NSJ5
LVNSNCVLKICDFGL	NLK	271	Q9UBE8
NLVEKTNCELKVCFQ	PADI2	326	Q9Y2J8
VVLRCCVSFNVDVKN	ITGA1	21	P56199
NIKKQQCEAIVGAQC	NSUN6	106	Q8TEA1
FVCAICQINLEGKTF	PDLIM7	426	Q9NR12
CNVKCQLLNLLLGVQ	DSTYK	121	Q6XUX3
FQLEKVLVTVGCTCV	IL17F	141	Q96PD4
CLSCIQGEVDVLVNN	RDH8	76	Q9NYR8
VKEEVAGQCQELQSC	PKD1L2	211	Q7Z442
KCIECVQPQSLQFII	PUM1	976	Q14671
VNIGCCIENVLLQQN	ICOSLG	211	O75144
EMKVNCLIQAQLGCI	HFM1	856	A2PYH4
LNVCNVCLGILQEFC	PUS10	106	Q3MIT2
CVSQFTLQCVLKGNK	DTD1	76	Q8TEA8
ELQRFACAVVCIQKA	ABCE1	221	P61221
HNLKICCRVNGEVVQ	FAHD2B	231	Q6P2I3
RQVVCGTKCNTLFVV	DCAF12	101	Q5T6F0
VECGPCQKVFVVQQI	CACNA2D4	1031	Q7Z3S7
VAQCLKIVCQVGRLD	ITGAV	906	P06756
LIKAVQCQNEDCATI	ANKRD7	96	Q92527
CTIQNFPKNVCSVVI	ENO4	91	A6NNW6
VVCGTKCNTLFVVDV	DCAF12L1	111	Q5VU92
CGPVNCNEKIVVLLQ	PSME1	101	Q06323
LKQFNVDICQTCFLT	DRP2	626	Q13474
ITIAGNHCEINCQKI	MTBP	201	Q96DY7
NVKCKIVVVGDSQCG	RND3	21	P61587
VCRVCQNKLFESIQE	MKNK1	316	Q9BUB5
QCSLKDQGLFIQCLI	PHTF2	36	Q8N3S3
AFQGRQKDCVIVTCV	SETX	2376	Q7Z333
QLGQVEIKCPITECF	RNF217	296	Q8TC41
CAFGCKIELQLFQTV	SLC10A5	156	Q5PT55
EACLQGNLIAICLEQ	RPTOR	551	Q8N122
IAGNCLVVISVCFVK	HTR7	96	P34969
VAADFIQQGIRCNCV	BDH2	161	Q9BUT1
LLVVQEQLEGQLQCC	CCDC136	946	Q96JN2
VACCNQFFVLDVVIN	CHAT	306	P28329
FQSIVNGCQEICVKE	ACAA2	96	P42765
IKVFVLCQGLLQLCQ	SLCO2A1	31	Q92959
FEIQIRDGQVQCLNC	RNF14	251	Q9UBS8
IVNCAIIANGITKAC	SUCLG2	366	Q96I99
CGQLVEAKCLTVNPQ	WDTC1	181	Q8N5D0
QSAECLVIGQIACQK	EEFSEC	126	P57772
LVDIACKVCQAYLGQ	TTLL8	266	A6PVC2
LALIGQFICSTVEQC	WASHC5	1096	Q12768
AELSCLQIFIQDQKC	VPS13A	1056	Q96RL7
CGVLAAVQGCVLQKL	MINDY4	456	Q4G0A6
TVDNEAGKITCLCQV	AARS1	891	P49588
KKVIQFVCGNGLVCE	SMC1B	606	Q8NDV3
CNINSQGVICLDILK	UBE2E3	136	Q969T4
QEFLLQCLCQGLKTQ	HEATR9	296	A2RTY3
VKTGQALVCPVCNVE	POLK	771	Q9UBT6
LQLKIGCTNVDECKV	ZNF728	111	P0DKX0
GAILCSQNICCQEIV	UBR1	1631	Q8IWV7
ICIECGQAFIQKTQL	ZNF585B	271	Q52M93
VQRFKCCQVNIEEGL	SCN8A	1166	Q9UQD0
IEQETLQQSGVCCKQ	PIGN	746	O95427
VIQNQFCHLCKVTVN	ZDHHC11	121	Q9H8X9
NNVLVIDGQQKRFCC	ZMYM2	481	Q9UBW7
QQRQLGLLCDCTFVV	ZBTB17	16	Q13105
ILVIGGQQKRFCCQS	ZMYM5	396	Q9UJ78
VQKQIIICGRQIICS	VPS13B	2721	Q7Z7G8
ENICLLNFFCGTIVL	TSPAN14	86	Q8NG11
SCLEIVLCGIQLVNA	TM4SF5	166	O14894
CPVCFTVFVQANKLQ	ZNF423	1231	Q2M1K9
VIQNQFCHLCKVTVN	ZDHHC11B	121	P0C7U3
LQVFQNELICCICVN	TRIM64	6	A6NGJ6
CTECGKVFIQKANLV	ZNF674	226	Q2M3X9
QKQLEGDCCSFITQL	UBR4	2611	Q5T4S7
CITCAVINRVQKVNC	EDA2R	61	Q9HAV5
LQVFQNELICCICVN	TRIM64B	6	A6NI03
LQCVLCVGLQFGKVD	ZNF638	1021	Q14966
QEVLQCILGNIQETC	USP1	201	O94782
CILGNIQETCQLLKK	USP1	206	O94782
TVVLNEEGICTQKCA	VPS39	226	Q96JC1
FGCTLQVMQDKIICL	LRRC8C	41	Q8TDW0