Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	transcription coregulator activity	ARID1A SS18 EWSR1 TDG FUS	1.89e-04	562	20	5	GO:0003712
GeneOntologyMolecularFunction	protein-macromolecule adaptor activity	ARID1A SS18 BET1 EWSR1 TDG FUS	7.26e-04	1160	20	6	GO:0030674
GeneOntologyMolecularFunction	molecular adaptor activity	ARID1A SS18 BET1 EWSR1 TDG FUS	1.64e-03	1356	20	6	GO:0060090
GeneOntologyMolecularFunction	DNA-binding transcription factor binding	EOMES ARID1A TDG FUS	2.39e-03	582	20	4	GO:0140297
GeneOntologyMolecularFunction	mRNA 3'-UTR binding	DAZAP1 HNRNPA1L2 FUS	2.50e-03	276	20	3	GO:0003730
GeneOntologyMolecularFunction	transcription coactivator activity	ARID1A SS18 FUS	3.26e-03	303	20	3	GO:0003713
GeneOntologyMolecularFunction	syntaxin binding	SYP BET1	3.39e-03	87	20	2	GO:0019905
GeneOntologyMolecularFunction	mRNA binding	DAZAP1 HNRNPAB HNRNPA1L2 FUS	4.49e-03	694	20	4	GO:0003729
GeneOntologyMolecularFunction	single-stranded RNA binding	DAZAP1 HNRNPA1L2	5.45e-03	111	20	2	GO:0003727
GeneOntologyMolecularFunction	transcription factor binding	EOMES ARID1A TDG FUS	6.00e-03	753	20	4	GO:0008134
GeneOntologyMolecularFunction	RNA polymerase II-specific DNA-binding transcription factor binding	EOMES ARID1A FUS	7.92e-03	417	20	3	GO:0061629
GeneOntologyMolecularFunction	SNARE binding	SYP BET1	8.07e-03	136	20	2	GO:0000149
GeneOntologyMolecularFunction	protein domain specific binding	SYP HOXB1 TDG HNRNPA1L2	1.01e-02	875	20	4	GO:0019904
GeneOntologyBiologicalProcess	placenta development	EOMES DAZAP1 ARID1A NDRG3	3.47e-05	197	20	4	GO:0001890
GeneOntologyBiologicalProcess	vesicle fusion with Golgi apparatus	BET1 YIPF5	4.00e-05	10	20	2	GO:0048280
GeneOntologyCellularComponent	npBAF complex	ARID1A SS18	7.86e-05	14	20	2	GO:0071564
GeneOntologyCellularComponent	SWI/SNF complex	ARID1A SS18	3.72e-04	30	20	2	GO:0016514
GeneOntologyCellularComponent	presynaptic cytosol	HNRNPAB FUS	9.95e-04	49	20	2	GO:0099523
Domain	RRM_1	DAZAP1 HNRNPAB EWSR1 HNRNPA1L2 FUS	2.21e-06	208	20	5	PF00076
Domain	RRM	DAZAP1 HNRNPAB EWSR1 HNRNPA1L2 FUS	2.72e-06	217	20	5	SM00360
Domain	RRM_dom	DAZAP1 HNRNPAB EWSR1 HNRNPA1L2 FUS	3.39e-06	227	20	5	IPR000504
Domain	RRM	DAZAP1 HNRNPAB EWSR1 HNRNPA1L2 FUS	3.62e-06	230	20	5	PS50102
Domain	-	DAZAP1 HNRNPAB EWSR1 HNRNPA1L2 FUS	4.82e-06	244	20	5	3.30.70.330
Domain	Nucleotide-bd_a/b_plait	DAZAP1 HNRNPAB EWSR1 HNRNPA1L2 FUS	6.33e-06	258	20	5	IPR012677
Domain	-	EWSR1 FUS	4.88e-05	10	20	2	4.10.1060.10
Domain	zf-RanBP	EWSR1 FUS	2.48e-04	22	20	2	PF00641
Domain	ZnF_RBZ	EWSR1 FUS	2.72e-04	23	20	2	SM00547
Domain	ZF_RANBP2_2	EWSR1 FUS	2.72e-04	23	20	2	PS50199
Domain	ZF_RANBP2_1	EWSR1 FUS	2.96e-04	24	20	2	PS01358
Domain	Znf_RanBP2	EWSR1 FUS	3.22e-04	25	20	2	IPR001876
Pathway	WP_MRNA_PROCESSING	DAZAP1 HNRNPAB EWSR1 HNRNPA1L2 FUS	1.07e-04	451	16	5	MM15946
Pubmed	FET family fusion oncoproteins target the SWI/SNF chromatin remodeling complex.	ARID1A SS18 EWSR1 FUS	6.99e-10	23	20	4	30962207
Pubmed	New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.	DAZAP1 HNRNPAB EWSR1 HNRNPA1L2 FUS HNRNPUL1 DYRK2	4.66e-09	462	20	7	31138677
Pubmed	The Deubiquitinating Enzyme USP48 Interacts with the Retinal Degeneration-Associated Proteins UNC119a and ARL3.	DAZAP1 SYP HNRNPAB EWSR1 HNRNPA1L2 FUS HNRNPUL1	1.58e-08	552	20	7	36293380
Pubmed	Characterization of ubiquitination dependent dynamics in growth factor receptor signaling by quantitative proteomics.	EWSR1 FUS HNRNPUL1	1.95e-08	10	20	3	21956701
Pubmed	The Human Tau Interactome: Binding to the Ribonucleoproteome, and Impaired Binding of the Proline-to-Leucine Mutant at Position 301 (P301L) to Chaperones and the Proteasome.	HNRNPAB EWSR1 FUS HNRNPUL1	1.95e-08	51	20	4	26269332
Pubmed	WW domains provide a platform for the assembly of multiprotein networks.	DAZAP1 ARID1A EWSR1 FUS HNRNPUL1	2.34e-08	154	20	5	16055720
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	DAZAP1 ARID1A SS18 HNRNPAB EWSR1 HNRNPA1L2 FUS HNRNPUL1	2.93e-08	954	20	8	36373674
Pubmed	The AERO system: a 3D-like approach for recording gene expression patterns in the whole mouse embryo.	EOMES HOXB1 HNRNPAB KANK1 FUS	6.87e-08	191	20	5	24146773
Pubmed	DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.	DAZAP1 ARID1A HNRNPAB EWSR1 FUS HNRNPUL1	1.57e-07	453	20	6	29656893
Pubmed	Interactome analyses revealed that the U1 snRNP machinery overlaps extensively with the RNAP II machinery and contains multiple ALS/SMA-causative proteins.	HNRNPAB CAT EWSR1 FUS HNRNPUL1	2.32e-07	244	20	5	29884807
Pubmed	Inhibition of SAPK2a/p38 prevents hnRNP A0 phosphorylation by MAPKAP-K2 and its interaction with cytokine mRNAs.	DAZAP1 HNRNPAB HNRNPA1L2	2.49e-07	22	20	3	12456657
Pubmed	EWS-FLI1 modulated alternative splicing of ARID1A reveals novel oncogenic function through the BAF complex.	ARID1A EWSR1	3.14e-07	2	20	2	31392992
Pubmed	Detection of SYT and EWS gene rearrangements by dual-color break-apart CISH in liquid-based cytology samples of synovial sarcoma and Ewing sarcoma/primitive neuroectodermal tumor.	SS18 EWSR1	3.14e-07	2	20	2	20660338
Pubmed	Expression patterns of the human sarcoma-associated genes FUS and EWS and the genomic structure of FUS.	EWSR1 FUS	3.14e-07	2	20	2	8921363
Pubmed	EWS and FUS bind a subset of transcribed genes encoding proteins enriched in RNA regulatory functions.	EWSR1 FUS	3.14e-07	2	20	2	26573619
Pubmed	A morphologic and molecular reappraisal of myoepithelial tumors of soft tissue, bone, and viscera with EWSR1 and FUS gene rearrangements.	EWSR1 FUS	3.14e-07	2	20	2	31994243
Pubmed	Identifying and quantifying in vivo methylation sites by heavy methyl SILAC.	HNRNPAB EWSR1 FUS	6.54e-07	30	20	3	15782174
Pubmed	Novel FUS-KLF17 and EWSR1-KLF17 fusions in myoepithelial tumors.	EWSR1 FUS	9.42e-07	3	20	2	25706482
Pubmed	FUS-NFATC2 or EWSR1-NFATC2 Fusions Are Present in a Large Proportion of Simple Bone Cysts.	EWSR1 FUS	9.42e-07	3	20	2	32991339
Pubmed	Ewing sarcoma with ERG gene rearrangements: A molecular study focusing on the prevalence of FUS-ERG and common pitfalls in detecting EWSR1-ERG fusions by FISH.	EWSR1 FUS	9.42e-07	3	20	2	26690869
Pubmed	Cytokeratin-positive Malignant Tumor in the Abdomen With EWSR1/FUS-CREB Fusion: A Clinicopathologic Study of 8 Cases.	EWSR1 FUS	9.42e-07	3	20	2	34049318
Pubmed	The multifunctional FUS, EWS and TAF15 proto-oncoproteins show cell type-specific expression patterns and involvement in cell spreading and stress response.	EWSR1 FUS	9.42e-07	3	20	2	18620564
Pubmed	O-GlcNAc glycosylation stoichiometry of the FET protein family: only EWS is glycosylated with a high stoichiometry.	EWSR1 FUS	9.42e-07	3	20	2	27903134
Pubmed	mRNA and protein levels of FUS, EWSR1, and TAF15 are upregulated in liposarcoma.	EWSR1 FUS	9.42e-07	3	20	2	21344536
Pubmed	Characterization of a new brain-specific isoform of the EWS oncoprotein.	EWSR1 FUS	9.42e-07	3	20	2	11422378
Pubmed	Multi-omic and functional analysis for classification and treatment of sarcomas with FUS-TFCP2 or EWSR1-TFCP2 fusions.	EWSR1 FUS	9.42e-07	3	20	2	38168093
Pubmed	A conserved N-terminal motif is required for complex formation between FUS, EWSR1, TAF15 and their oncogenic fusion proteins.	EWSR1 FUS	9.42e-07	3	20	2	23975937
Pubmed	A Subset of Malignant Mesotheliomas in Young Adults Are Associated With Recurrent EWSR1/FUS-ATF1 Fusions.	EWSR1 FUS	9.42e-07	3	20	2	28505004
Pubmed	Gene expression responses to FUS, EWS, and TAF15 reduction and stress granule sequestration analyses identifies FET-protein non-redundant functions.	EWSR1 FUS	9.42e-07	3	20	2	23049996
Pubmed	Aggregation of FET Proteins as a Pathological Change in Amyotrophic Lateral Sclerosis.	EWSR1 FUS	9.42e-07	3	20	2	27311318
Pubmed	FET proteins TAF15 and EWS are selective markers that distinguish FTLD with FUS pathology from amyotrophic lateral sclerosis with FUS mutations.	EWSR1 FUS	9.42e-07	3	20	2	21856723
Pubmed	Unclassified low grade spindle cell sarcoma with storiform pattern characterized by recurrent novel EWSR1/FUS-NACC1 fusions.	EWSR1 FUS	9.42e-07	3	20	2	33859361
Pubmed	Role of FET proteins in neurodegenerative disorders.	EWSR1 FUS	9.42e-07	3	20	2	27415968
Pubmed	ARIH2 Is a Vif-Dependent Regulator of CUL5-Mediated APOBEC3G Degradation in HIV Infection.	DAZAP1 HNRNPAB EWSR1 FUS HNRNPUL1	1.12e-06	336	20	5	31253590
Pubmed	PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry.	DAZAP1 HNRNPAB EWSR1 FUS HNRNPUL1	1.19e-06	340	20	5	24332808
Pubmed	A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain.	DAZAP1 HNRNPAB EWSR1 HNRNPA1L2 FUS	1.32e-06	347	20	5	16033648
Pubmed	Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets.	ARID1A CAT EWSR1 TDG	1.83e-06	157	20	4	30686591
Pubmed	Post-transcriptional regulation of FUS and EWS protein expression by miR-141 during neural differentiation.	EWSR1 FUS	1.88e-06	4	20	2	28453628
Pubmed	The neurodegenerative diseases ALS and SMA are linked at the molecular level via the ASC-1 complex.	EWSR1 FUS	1.88e-06	4	20	2	30398641
Pubmed	The transcriptional repressor ZFM1 interacts with and modulates the ability of EWS to activate transcription.	EWSR1 FUS	1.88e-06	4	20	2	9660765
Pubmed	Characterization of TFG in mus musculus and Caenorhabditis elegans.	EWSR1 FUS	1.88e-06	4	20	2	10092511
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	ARID1A SS18 HNRNPAB KANK1 HNRNPA1L2 FUS HNRNPUL1	2.32e-06	1155	20	7	20360068
Pubmed	Beads-free protein immunoprecipitation for a mass spectrometry-based interactome and posttranslational modifications analysis.	DAZAP1 HNRNPAB HNRNPA1L2 FUS	2.63e-06	172	20	4	26336360
Pubmed	Impact of heterogeneous nuclear ribonucleoprotein A/B subtype overexpression on the expression of cancer stem cell markers CD133 and CD44 and cellular proliferation capacity.	HNRNPAB HNRNPA1L2	3.14e-06	5	20	2	38279469
Pubmed	IGF1 is a common target gene of Ewing's sarcoma fusion proteins in mesenchymal progenitor cells.	EWSR1 FUS	3.14e-06	5	20	2	18648544
Pubmed	Loss of TRIM31 promotes breast cancer progression through regulating K48- and K63-linked ubiquitination of p53.	SS18 HNRNPAB EWSR1 FUS HNRNPUL1	3.39e-06	421	20	5	34650049
Pubmed	Proteomic Analysis of the EWS-Fli-1 Interactome Reveals the Role of the Lysosome in EWS-Fli-1 Turnover.	DAZAP1 ARID1A HNRNPAB EWSR1 FUS	3.55e-06	425	20	5	24999758
Pubmed	The nuclear transcription factor RARalpha associates with neuronal RNA granules and suppresses translation.	HNRNPAB EWSR1 FUS	3.96e-06	54	20	3	18495661
Pubmed	C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.	DAZAP1 HNRNPAB EWSR1 YIPF5 HNRNPA1L2 FUS HNRNPUL1	4.06e-06	1257	20	7	37317656
Pubmed	Induced ncRNAs allosterically modify RNA-binding proteins in cis to inhibit transcription.	EWSR1 FUS	4.71e-06	6	20	2	18509338
Pubmed	Deletion of a single allele of the Pex11β gene is sufficient to cause oxidative stress, delayed differentiation and neuronal death in mouse brain.	SYP CAT	4.71e-06	6	20	2	21954064
Pubmed	The hnRNP RALY regulates PRMT1 expression and interacts with the ALS-linked protein FUS: implication for reciprocal cellular localization.	EWSR1 FUS	4.71e-06	6	20	2	30354839
Pubmed	Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.	DAZAP1 ARID1A BET1 EWSR1 FUS	5.05e-06	457	20	5	32344865
Pubmed	Host cell interactome of HIV-1 Rev includes RNA helicases involved in multiple facets of virus production.	DAZAP1 HNRNPAB EWSR1 FUS	5.38e-06	206	20	4	22174317
Pubmed	Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage.	HNRNPAB CAT EWSR1 HNRNPA1L2 FUS HNRNPUL1	5.81e-06	844	20	6	25963833
Pubmed	SARS-CoV-2 spike protein induces endothelial inflammation via ACE2 independently of viral replication.	DAZAP1 HNRNPAB FUS HNRNPUL1	6.48e-06	216	20	4	37640791
Pubmed	Defects in embryonic neurogenesis and initial synapse formation in the forebrain of the Ts65Dn mouse model of Down syndrome.	EOMES SYP	6.59e-06	7	20	2	17959791
Pubmed	Reversible disruption of mSWI/SNF (BAF) complexes by the SS18-SSX oncogenic fusion in synovial sarcoma.	ARID1A SS18	6.59e-06	7	20	2	23540691
Pubmed	Loss of BAF (mSWI/SNF) Complexes Causes Global Transcriptional and Chromatin State Changes in Forebrain Development.	EOMES ARID1A SS18	6.94e-06	65	20	3	26655900
Pubmed	TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.	DAZAP1 ARID1A HNRNPAB HNRNPUL1	6.97e-06	220	20	4	35785414
Pubmed	The RNA-binding protein HuR is a novel target of Pirh2 E3 ubiquitin ligase.	HNRNPAB EWSR1 FUS HNRNPUL1	6.97e-06	220	20	4	34091597
Pubmed	Ovarian tumorB1-mediated heat shock transcription factor 1 deubiquitination is critical for glycolysis and development of endometriosis.	CAT EWSR1 FUS HNRNPUL1	9.19e-06	236	20	4	36339263
Pubmed	The SARS-CoV-2 RNA interactome.	DAZAP1 HNRNPAB EWSR1	1.03e-05	74	20	3	33989516
Pubmed	Identification of proteins associated with ligand-activated estrogen receptor α in human breast cancer cell nuclei by tandem affinity purification and nano LC-MS/MS.	HNRNPAB EWSR1 HNRNPA1L2 FUS	1.07e-05	245	20	4	21182205
Pubmed	TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1.	HNRNPAB CAT EWSR1 HNRNPA1L2 FUS HNRNPUL1	1.13e-05	949	20	6	36574265
Pubmed	Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair.	HNRNPAB CAT EWSR1 FUS HNRNPUL1	1.25e-05	551	20	5	34728620
Pubmed	Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms.	HNRNPAB EWSR1 HNRNPA1L2 FUS	1.27e-05	256	20	4	24189400
Pubmed	SND1 binds SARS-CoV-2 negative-sense RNA and promotes viral RNA synthesis through NSP9.	DAZAP1 HNRNPAB EWSR1 FUS	1.31e-05	258	20	4	37794589
Pubmed	Circular RNA circPVT1 promotes nasopharyngeal carcinoma metastasis via the β-TrCP/c-Myc/SRSF1 positive feedback loop.	HNRNPAB EWSR1 FUS HNRNPUL1	1.35e-05	260	20	4	36199071
Pubmed	ABHD4-dependent developmental anoikis safeguards the embryonic brain.	EOMES CAT	1.41e-05	10	20	2	32868797
Pubmed	TDRD3, a novel Tudor domain-containing protein, localizes to cytoplasmic stress granules.	EWSR1 FUS	1.41e-05	10	20	2	18632687
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	DAZAP1 HNRNPAB CAT EWSR1 FUS HNRNPUL1	1.43e-05	989	20	6	36424410
Pubmed	The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted antiviral signaling and host translation.	DAZAP1 NDRG3 BET1 EWSR1 FUS HNRNPUL1	1.59e-05	1007	20	6	34597346
Pubmed	mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis.	HNRNPAB EWSR1 FUS HNRNPUL1	1.65e-05	274	20	4	34244482
Pubmed	Epidermal progenitors suppress GRHL3-mediated differentiation through intronic polyadenylation promoted by CPSF-HNRNPA3 collaboration.	FUS HNRNPUL1	1.72e-05	11	20	2	33469008
Pubmed	Nuclear heterogeneous nuclear ribonucleoprotein D is associated with poor prognosis and interactome analysis reveals its novel binding partners in oral cancer.	HNRNPAB EWSR1 FUS	1.73e-05	88	20	3	26318153
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	DAZAP1 HNRNPAB CAT EWSR1 FUS HNRNPUL1	1.75e-05	1024	20	6	24711643
Pubmed	Cleavage and polyadenylation specificity factor 1 (CPSF1) regulates alternative splicing of interleukin 7 receptor (IL7R) exon 6.	HNRNPAB FUS HNRNPUL1	1.85e-05	90	20	3	23151878
Pubmed	Histone-binding of DPF2 mediates its repressive role in myeloid differentiation.	ARID1A HNRNPAB EWSR1 FUS	1.88e-05	283	20	4	28533407
Pubmed	SYT associates with human SNF/SWI complexes and the C-terminal region of its fusion partner SSX1 targets histones.	ARID1A SS18	2.07e-05	12	20	2	11734557
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	DAZAP1 ARID1A HNRNPAB EWSR1 FUS HNRNPUL1	2.66e-05	1103	20	6	34189442
Pubmed	Kinetic analysis of npBAF to nBAF switching reveals exchange of SS18 with CREST and integration with neural developmental pathways.	ARID1A SS18	3.28e-05	15	20	2	23785148
Pubmed	Lysosomal Signaling Licenses Embryonic Stem Cell Differentiation via Inactivation of Tfe3.	HNRNPAB EWSR1 HNRNPA1L2 FUS	3.50e-05	332	20	4	30595499
Pubmed	Pluripotency factors regulate definitive endoderm specification through eomesodermin.	EOMES HOXB1	3.75e-05	16	20	2	21245162
Pubmed	SETD5 Regulates Chromatin Methylation State and Preserves Global Transcriptional Fidelity during Brain Development and Neuronal Wiring.	EOMES SYP	3.75e-05	16	20	2	31515109
Pubmed	Liver X receptor β regulates the development of the dentate gyrus and autistic-like behavior in the mouse.	EOMES SYP	3.75e-05	16	20	2	29507213
Pubmed	Loss of function of mouse Pax-Interacting Protein 1-associated glutamate rich protein 1a (Pagr1a) leads to reduced Bmp2 expression and defects in chorion and amnion development.	EOMES HOXB1	3.75e-05	16	20	2	24633704
Pubmed	Tbr2 deficiency in mitral and tufted cells disrupts excitatory-inhibitory balance of neural circuitry in the mouse olfactory bulb.	EOMES SYP	3.75e-05	16	20	2	22745484
Pubmed	Composition and three-dimensional EM structure of double affinity-purified, human prespliceosomal A complexes.	HNRNPAB FUS HNRNPUL1	3.85e-05	115	20	3	17332742
Pubmed	ATG5 is required for B cell polarization and presentation of particulate antigens.	HNRNPAB EWSR1 HNRNPA1L2 FUS HNRNPUL1	3.96e-05	701	20	5	30196744
Pubmed	Mutual regulation between OGT and XIAP to control colon cancer cell growth and invasion.	DAZAP1 HNRNPAB CAT EWSR1 FUS	4.04e-05	704	20	5	32994395
Pubmed	hnRNPA1 couples nuclear export and translation of specific mRNAs downstream of FGF-2/S6K2 signalling.	HNRNPAB EWSR1 FUS HNRNPUL1	4.11e-05	346	20	4	25324306
Pubmed	Defective neurite elongation and branching in Nibp/Trappc9 deficient zebrafish and mice.	EOMES SYP	4.25e-05	17	20	2	37416774
Pubmed	Arginine methylation of SARS-Cov-2 nucleocapsid protein regulates RNA binding, its ability to suppress stress granule formation, and viral replication.	HNRNPAB EWSR1 HNRNPUL1	4.48e-05	121	20	3	34029587
Pubmed	Elucidation of the 14-3-3ζ interactome reveals critical roles of RNA-splicing factors during adipogenesis.	EWSR1 HNRNPA1L2 FUS	4.60e-05	122	20	3	29530978
Pubmed	Prohibitin 1 regulates tumor cell apoptosis via the interaction with X-linked inhibitor of apoptosis protein.	DAZAP1 HNRNPAB EWSR1 FUS HNRNPUL1	4.64e-05	725	20	5	27025967
Pubmed	Haploinsufficiency for Core Exon Junction Complex Components Disrupts Embryonic Neurogenesis and Causes p53-Mediated Microcephaly.	EOMES FUS	4.78e-05	18	20	2	27618312
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	HNRNPAB CAT EWSR1 YIPF5 FUS HNRNPUL1	5.52e-05	1257	20	6	36526897
Pubmed	Enhancer recruitment of transcription repressors RUNX1 and TLE3 by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia.	ARID1A EWSR1 HNRNPUL1	5.68e-05	131	20	3	34551306
Pubmed	Identification of 14-3-3epsilon substrates from embryonic murine brain.	HNRNPAB EWSR1 FUS	5.81e-05	132	20	3	16944949
Interaction	FLI1 interactions	ARID1A SS18 EWSR1 FUS	3.79e-07	62	20	4	int:FLI1
Interaction	RCHY1 interactions	HOXB1 HNRNPAB EWSR1 FUS HNRNPUL1 DYRK2	5.38e-07	325	20	6	int:RCHY1
Interaction	NEDD8 interactions	DAZAP1 NDRG3 HNRNPAB EWSR1 FUS HNRNPUL1	1.63e-06	393	20	6	int:NEDD8
Interaction	TAF15 interactions	ARID1A HNRNPAB CAT EWSR1 FUS HNRNPUL1	2.02e-06	408	20	6	int:TAF15
Interaction	RARA interactions	ARID1A HNRNPAB EWSR1 TDG FUS	2.15e-06	223	20	5	int:RARA
Interaction	NUP35 interactions	DAZAP1 ARID1A BET1 EWSR1 HNRNPA1L2 FUS	2.53e-06	424	20	6	int:NUP35
Interaction	SMC5 interactions	DAZAP1 ARID1A SS18 HNRNPAB EWSR1 HNRNPA1L2 FUS HNRNPUL1	2.64e-06	1000	20	8	int:SMC5
Interaction	SMARCA4 interactions	ARID1A SS18 CAT EWSR1 HNRNPA1L2 FUS	4.15e-06	462	20	6	int:SMARCA4
Interaction	DDIT3 interactions	ARID1A SS18 EWSR1 FUS	5.38e-06	120	20	4	int:DDIT3
Interaction	CELF1 interactions	DAZAP1 HNRNPAB EWSR1 FUS HNRNPUL1	7.49e-06	288	20	5	int:CELF1
Interaction	TP53BP1 interactions	DAZAP1 ARID1A HNRNPAB EWSR1 FUS HNRNPUL1	9.40e-06	533	20	6	int:TP53BP1
Interaction	ARIH2 interactions	DAZAP1 HNRNPAB EWSR1 FUS HNRNPUL1	1.14e-05	314	20	5	int:ARIH2
Interaction	CUL1 interactions	DAZAP1 ARID1A TNS2 HNRNPAB EWSR1 FUS HNRNPUL1	1.35e-05	876	20	7	int:CUL1
Interaction	CUL2 interactions	DAZAP1 ARID1A HNRNPAB EWSR1 FUS HNRNPUL1	1.69e-05	591	20	6	int:CUL2
Interaction	HNRNPDL interactions	HNRNPAB EWSR1 HNRNPA1L2 FUS HNRNPUL1	2.32e-05	364	20	5	int:HNRNPDL
Interaction	SNRNP40 interactions	DAZAP1 ARID1A HNRNPAB EWSR1 FUS HNRNPUL1	2.58e-05	637	20	6	int:SNRNP40
Interaction	MYCN interactions	DAZAP1 ARID1A SS18 HNRNPAB EWSR1 HNRNPA1L2 FUS HNRNPUL1	2.73e-05	1373	20	8	int:MYCN
Interaction	USP48 interactions	DAZAP1 SYP HNRNPAB EWSR1 FUS HNRNPUL1	3.38e-05	668	20	6	int:USP48
Interaction	BICRA interactions	ARID1A SS18 EWSR1	3.84e-05	67	20	3	int:BICRA
Interaction	GATA4 interactions	ARID1A SS18 HNRNPAB EWSR1 FUS	4.15e-05	411	20	5	int:GATA4
Interaction	ETV4 interactions	ARID1A SS18 HNRNPUL1	4.20e-05	69	20	3	int:ETV4
Interaction	RBM45 interactions	HNRNPAB EWSR1 FUS HNRNPUL1	4.60e-05	207	20	4	int:RBM45
Interaction	ACE2 interactions	DAZAP1 HNRNPAB CAT EWSR1 HNRNPA1L2 FUS HNRNPUL1	6.06e-05	1106	20	7	int:ACE2
Interaction	ERG interactions	ARID1A SS18 HNRNPAB HNRNPUL1	6.15e-05	223	20	4	int:ERG
Interaction	TRIM31 interactions	SS18 HNRNPAB EWSR1 FUS HNRNPUL1	6.65e-05	454	20	5	int:TRIM31
Interaction	PHB1 interactions	DAZAP1 ARID1A HNRNPAB EWSR1 YIPF5 FUS HNRNPUL1	6.68e-05	1123	20	7	int:PHB1
Interaction	FUS interactions	ARID1A SS18 HNRNPAB EWSR1 FUS HNRNPUL1	6.79e-05	757	20	6	int:FUS
Interaction	RBMX interactions	HNRNPAB EWSR1 HNRNPA1L2 FUS HNRNPUL1	7.15e-05	461	20	5	int:RBMX
Interaction	BTRC interactions	ARID1A TNS2 HNRNPAB EWSR1 FUS HNRNPUL1	7.74e-05	775	20	6	int:BTRC
Interaction	SS18 interactions	ARID1A SS18 FUS	8.69e-05	88	20	3	int:SS18
Interaction	SNRPA interactions	DAZAP1 HNRNPAB EWSR1 FUS HNRNPUL1	8.83e-05	482	20	5	int:SNRPA
Interaction	ADCK5 interactions	TNS2 FUS	1.26e-04	17	20	2	int:ADCK5
Interaction	TARDBP interactions	NDRG3 HNRNPAB EWSR1 FUS HNRNPUL1	1.26e-04	520	20	5	int:TARDBP
Interaction	BRCA1 interactions	DAZAP1 ARID1A TNS2 HNRNPAB EWSR1 FUS HNRNPUL1	1.31e-04	1249	20	7	int:BRCA1
Interaction	MEPCE interactions	HNRNPAB EWSR1 HNRNPA1L2 FUS HNRNPUL1 DYRK2	1.37e-04	859	20	6	int:MEPCE
Interaction	DCUN1D1 interactions	HNRNPAB EWSR1 FUS HNRNPUL1	1.38e-04	275	20	4	int:DCUN1D1
Interaction	CNBP interactions	NDRG3 BET1 HNRNPAB HNRNPUL1	1.40e-04	276	20	4	int:CNBP
Interaction	ARID1A interactions	ARID1A SS18 EWSR1 FUS	1.40e-04	276	20	4	int:ARID1A
Interaction	CSTF1 interactions	NDRG3 TNS2 FUS	1.43e-04	104	20	3	int:CSTF1
Interaction	METTL14 interactions	HNRNPAB CAT EWSR1 FUS HNRNPUL1	1.76e-04	558	20	5	int:METTL14
Interaction	OBSL1 interactions	DAZAP1 TNS2 HNRNPAB EWSR1 FUS HNRNPUL1	1.78e-04	902	20	6	int:OBSL1
Interaction	EWSR1 interactions	DAZAP1 ARID1A HNRNPAB EWSR1 FUS HNRNPUL1	1.83e-04	906	20	6	int:EWSR1
Interaction	C9orf72 interactions	DAZAP1 HNRNPAB EWSR1 YIPF5 HNRNPA1L2 FUS HNRNPUL1	1.84e-04	1319	20	7	int:C9orf72
Interaction	FUBP3 interactions	DAZAP1 FUS HNRNPUL1 DYRK2	1.86e-04	297	20	4	int:FUBP3
Interaction	CUL5 interactions	DAZAP1 HNRNPAB EWSR1 FUS HNRNPUL1	1.89e-04	567	20	5	int:CUL5
Interaction	DDX5 interactions	HNRNPAB EWSR1 FUS HNRNPUL1 DYRK2	1.91e-04	568	20	5	int:DDX5
Interaction	TTN interactions	HNRNPAB EWSR1 HNRNPA1L2 DYRK2	1.91e-04	299	20	4	int:TTN
Interaction	RNU1-1 interactions	EWSR1 FUS	1.94e-04	21	20	2	int:RNU1-1
Interaction	HNRNPH3 interactions	EWSR1 HNRNPA1L2 FUS HNRNPUL1	1.96e-04	301	20	4	int:HNRNPH3
Interaction	SCARNA22 interactions	HNRNPAB EWSR1 FUS	2.07e-04	118	20	3	int:SCARNA22
Interaction	PRMT1 interactions	TNS2 HNRNPAB CAT EWSR1 FUS HNRNPUL1	2.10e-04	929	20	6	int:PRMT1
Interaction	MRPS18B interactions	BET1 HNRNPAB EWSR1 FUS	2.11e-04	307	20	4	int:MRPS18B
Interaction	UPF1 interactions	DAZAP1 HNRNPAB EWSR1 FUS DYRK2	2.12e-04	581	20	5	int:UPF1
Interaction	HNRNPA1 interactions	DAZAP1 HNRNPAB EWSR1 HNRNPA1L2 FUS HNRNPUL1	2.30e-04	945	20	6	int:HNRNPA1
Interaction	OGT interactions	DAZAP1 TNS2 HNRNPAB CAT EWSR1 FUS	2.37e-04	950	20	6	int:OGT
Interaction	CREBBP interactions	ARID1A HOXB1 EWSR1 TDG FUS	2.44e-04	599	20	5	int:CREBBP
Interaction	GLDC interactions	HNRNPAB EWSR1 FUS HNRNPUL1	2.50e-04	321	20	4	int:GLDC
Interaction	SAR1A interactions	DAZAP1 NDRG3 BET1 YIPF5	2.62e-04	325	20	4	int:SAR1A
Interaction	HSF1 interactions	HNRNPAB CAT EWSR1 FUS HNRNPUL1	2.64e-04	609	20	5	int:HSF1
Interaction	BLZF1 interactions	BET1 TNS2 EWSR1	2.64e-04	128	20	3	int:BLZF1
Interaction	EP300 interactions	ARID1A SS18 HOXB1 EWSR1 TDG FUS HNRNPUL1	2.68e-04	1401	20	7	int:EP300
Interaction	LDHB interactions	HNRNPAB CAT EWSR1 FUS	2.68e-04	327	20	4	int:LDHB
Interaction	BRD7 interactions	ARID1A SS18 HNRNPAB EWSR1 HNRNPUL1	3.24e-04	637	20	5	int:BRD7
Interaction	HNRNPD interactions	DAZAP1 HNRNPAB EWSR1 HNRNPA1L2 FUS	3.27e-04	638	20	5	int:HNRNPD
Interaction	HLTF interactions	ARID1A EWSR1 HNRNPA1L2	3.36e-04	139	20	3	int:HLTF
Interaction	PHF10 interactions	ARID1A SS18 FUS	3.36e-04	139	20	3	int:PHF10
Interaction	HNRNPA0 interactions	HNRNPAB HNRNPA1L2 FUS HNRNPUL1	3.44e-04	349	20	4	int:HNRNPA0
Interaction	IL7R interactions	HNRNPAB FUS HNRNPUL1	3.50e-04	141	20	3	int:IL7R
Interaction	SMARCC2 interactions	ARID1A SS18 EWSR1 FUS	3.59e-04	353	20	4	int:SMARCC2
Interaction	ITCH interactions	DAZAP1 ARID1A EWSR1 HNRNPUL1	3.71e-04	356	20	4	int:ITCH
Interaction	BMI1 interactions	DAZAP1 HNRNPAB EWSR1 FUS HNRNPUL1	3.79e-04	659	20	5	int:BMI1
Interaction	ELF5 interactions	EOMES ARID1A SS18	3.96e-04	147	20	3	int:ELF5
Interaction	PPIL1 interactions	EWSR1 FUS HNRNPUL1	3.96e-04	147	20	3	int:PPIL1
Interaction	COX6B1 interactions	SYP YIPF5 DYRK2	4.20e-04	150	20	3	int:COX6B1
Interaction	HNRNPAB interactions	HNRNPAB EWSR1 HNRNPA1L2 FUS	4.33e-04	371	20	4	int:HNRNPAB
Interaction	ARID2 interactions	ARID1A SS18 FUS	4.45e-04	153	20	3	int:ARID2
Interaction	ZCCHC8 interactions	CAT EWSR1 FUS	4.53e-04	154	20	3	int:ZCCHC8
Interaction	MCM2 interactions	HNRNPAB CAT EWSR1 HNRNPA1L2 FUS HNRNPUL1	4.75e-04	1081	20	6	int:MCM2
Interaction	BRCA2 interactions	ARID1A CAT EWSR1 TDG	4.94e-04	384	20	4	int:BRCA2
Interaction	SMARCC1 interactions	ARID1A SS18 EWSR1 FUS	4.94e-04	384	20	4	int:SMARCC1
Interaction	CSTF2 interactions	DAZAP1 EWSR1 FUS	5.55e-04	165	20	3	int:CSTF2
Interaction	LARP7 interactions	HNRNPAB EWSR1 HNRNPA1L2 FUS HNRNPUL1 DYRK2	5.55e-04	1113	20	6	int:LARP7
Interaction	SYNCRIP interactions	SS18 HNRNPAB EWSR1 FUS HNRNPUL1	5.73e-04	721	20	5	int:SYNCRIP
Interaction	CUL4B interactions	DAZAP1 HNRNPAB EWSR1 FUS HNRNPUL1	5.99e-04	728	20	5	int:CUL4B
Interaction	PIH1D1 interactions	DAZAP1 HNRNPAB EWSR1 FUS HNRNPUL1	6.10e-04	731	20	5	int:PIH1D1
Interaction	COPS6 interactions	HNRNPAB EWSR1 FUS HNRNPUL1	6.20e-04	408	20	4	int:COPS6
Interaction	MDC1 interactions	ARID1A HNRNPAB EWSR1 FUS	6.55e-04	414	20	4	int:MDC1
Interaction	RNF8 interactions	CAT EWSR1 FUS DYRK2	6.98e-04	421	20	4	int:RNF8
Interaction	NKD2 interactions	EWSR1 FUS	7.14e-04	40	20	2	int:NKD2
Interaction	NKX2-1 interactions	TDG FUS HNRNPUL1	7.14e-04	180	20	3	int:NKX2-1
Interaction	SOD1 interactions	DAZAP1 HNRNPAB CAT EWSR1	7.62e-04	431	20	4	int:SOD1
Interaction	PCM1 interactions	EWSR1 FUS HNRNPUL1 DYRK2	7.82e-04	434	20	4	int:PCM1
Interaction	SNRPC interactions	HNRNPAB EWSR1 FUS HNRNPUL1	8.23e-04	440	20	4	int:SNRPC
Interaction	PABPN1 interactions	HNRNPAB EWSR1 FUS	8.61e-04	192	20	3	int:PABPN1
Interaction	TNIP1 interactions	HNRNPAB CAT EWSR1 HNRNPA1L2 FUS HNRNPUL1	8.91e-04	1217	20	6	int:TNIP1
Interaction	SAFB2 interactions	EWSR1 FUS HNRNPUL1	9.01e-04	195	20	3	int:SAFB2
Interaction	MAPK1IP1L interactions	EWSR1 HNRNPUL1	9.03e-04	45	20	2	int:MAPK1IP1L
Interaction	DDX1 interactions	EWSR1 FUS HNRNPUL1 DYRK2	9.95e-04	463	20	4	int:DDX1
Interaction	SORBS3 interactions	SYP TNS2 HNRNPUL1	9.97e-04	202	20	3	int:SORBS3
Interaction	RAB1A interactions	DAZAP1 YIPF5 HNRNPA1L2 HNRNPUL1	1.00e-03	464	20	4	int:RAB1A
GeneFamily	RNA binding motif containing	DAZAP1 HNRNPAB EWSR1 HNRNPA1L2 FUS	3.98e-07	213	14	5	725
GeneFamily	Zinc fingers RANBP2-type \|RNA binding motif containing	EWSR1 FUS	1.16e-04	21	14	2	89
ToppCell	Hippocampus-Macroglia-POLYDENDROCYTE-P5\|Hippocampus / BrainAtlas - Mouse McCarroll V32	EOMES DAZAP1 HNRNPAB EWSR1 FUS	1.43e-08	180	20	5	44988c34861df359a68376500c42a64fbcc4b431
ToppCell	Hippocampus-Macroglia-POLYDENDROCYTE-P5-P5_2\|Hippocampus / BrainAtlas - Mouse McCarroll V32	EOMES HNRNPAB EWSR1 FUS	3.73e-07	136	20	4	3e13dc0634f3b05e9f9e6c3193f843f62e603b78
ToppCell	Hippocampus-Macroglia-POLYDENDROCYTE-P5-P5_2-Sox4\|Hippocampus / BrainAtlas - Mouse McCarroll V32	EOMES HNRNPAB EWSR1 FUS	3.73e-07	136	20	4	0185486c39700dd2f72d79be6d283494dd8379c9
ToppCell	Hippocampus-Macroglia-POLYDENDROCYTE\|Hippocampus / BrainAtlas - Mouse McCarroll V32	EOMES DAZAP1 HNRNPAB EWSR1	1.36e-06	188	20	4	8bd6f2cd1aadbd6f9ed31b160f59c1eff144e1dc
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c01-LEF1\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	SYP FUS DYRK2	7.29e-05	184	20	3	bd786db4dc4edae6d5cfc0b69901983dea19f729
ToppCell	pdx\|World / Sample and Cell Type and Tumor Cluster (all cells)	ARID1A KANK1 FUS	7.53e-05	186	20	3	de8e538c8767d41b8a52f5e58ba1affd4e7244c4
ToppCell	pdx-Tumor_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	ARID1A KANK1 FUS	7.53e-05	186	20	3	0b88a87158a9ca8de3bf40a4ff1687150707a5f0
ToppCell	ASK428-Immune-NK_cell\|Immune / Donor, Lineage and Cell class of Lung cells from Dropseq	EOMES EWSR1 FUS	8.02e-05	190	20	3	d649f7e17c4227787465dfc02037f791ff85378b
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW13-Stem_cells\|GW13 / Sample Type, Dataset, Time_group, and Cell type.	EOMES ARID1A HNRNPUL1	9.19e-05	199	20	3	fd1d1b95e01719e3d0a17d9d1f29717a47209d32
ToppCell	megakaryocytic-CD34+_Megakaryoblast\|megakaryocytic / Lineage and Cell class	HNRNPAB CAT FUS	9.19e-05	199	20	3	99a65887d3c8a2cde26693dd74404b101bba9d58
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW13-Stem_cells-Stem_cells\|GW13 / Sample Type, Dataset, Time_group, and Cell type.	EOMES ARID1A HNRNPUL1	9.19e-05	199	20	3	91882af9dc7265c9b419f4415cbcf656087a2ab3
ToppCell	HSPCs\|World / Lineage and Cell class	DAZAP1 HNRNPAB EWSR1	9.19e-05	199	20	3	df1ffc416c6946f1ba182f242a50ee41a571d565
ToppCell	(5)_Fibroblasts-(5)_Fibroblast-H\|(5)_Fibroblasts / Lung cell shreds - cell class (v4) and cell subclass (v4)	DAZAP1 HNRNPAB EWSR1	9.33e-05	200	20	3	0ebc54d19873a2b7b6d12b81559cb12abd73b90c
Computational	Neighborhood of CDK2	HNRNPAB FUS DYRK2	1.24e-04	72	15	3	MORF_CDK2
Computational	Neighborhood of FBL	HNRNPAB FUS HNRNPUL1	8.77e-04	140	15	3	MORF_FBL
Computational	Neighborhood of PTK2	NDRG3 TNS2 YIPF5	9.71e-04	145	15	3	GCM_PTK2
Computational	Neighborhood of TDG	HNRNPAB TDG	1.05e-03	35	15	2	GNF2_TDG
Computational	Neighborhood of PSMC1	HNRNPAB TDG HNRNPUL1	2.11e-03	190	15	3	MORF_PSMC1
Computational	Neighborhood of RAN	NDRG3 TNS2 YIPF5	2.31e-03	196	15	3	GCM_RAN
Computational	Neighborhood of ANP32B	HNRNPAB FUS HNRNPUL1	2.38e-03	198	15	3	MORF_ANP32B
Computational	Neighborhood of AATF	HNRNPAB FUS DYRK2	2.77e-03	209	15	3	MORF_AATF
Computational	Neighborhood of DEK	HNRNPAB TDG	2.87e-03	58	15	2	GNF2_DEK
Computational	Neighborhood of ESPL1	HNRNPAB FUS	3.17e-03	61	15	2	MORF_ESPL1
Computational	Neighborhood of TERF1	FUS HNRNPUL1	3.81e-03	67	15	2	MORF_TERF1
Computational	Neighborhood of XRCC5	HNRNPAB FUS HNRNPUL1	3.86e-03	235	15	3	MORF_XRCC5
Computational	Neighborhood of UBE2I	HNRNPAB FUS HNRNPUL1	4.00e-03	238	15	3	MORF_UBE2I
Computational	Genes in the cancer module 32.	EWSR1 FUS HNRNPUL1	4.15e-03	241	15	3	MODULE_32
Computational	Neighborhood of HDAC1	HNRNPAB FUS HNRNPUL1	4.81e-03	254	15	3	MORF_HDAC1
Computational	Neighborhood of DEK	HNRNPAB FUS HNRNPUL1	5.35e-03	264	15	3	MORF_DEK
Computational	Neighborhood of RAN	HNRNPAB FUS HNRNPUL1	5.58e-03	268	15	3	MORF_RAN
Computational	Neighborhood of PCNA	HNRNPAB FUS	5.79e-03	83	15	2	MORF_PCNA
Computational	Neighborhood of BUB3	HNRNPAB FUS HNRNPUL1	6.12e-03	277	15	3	MORF_BUB3
Drug	2d41	SS18 EWSR1 FUS	1.67e-06	27	20	3	CID009543496
Drug	A-skin	SYP EWSR1 FUS	2.83e-06	32	20	3	CID000208772
Drug	12-mo	SYP CAT EWSR1	4.42e-06	37	20	3	CID000001420
Drug	thymine glycol	CAT TDG FUS	1.11e-05	50	20	3	CID000018058
Drug	Baclofen (R,S) [1134-47-0]; Down 200; 18.8uM; HL60; HG-U133A	ARID1A HNRNPAB CAT FUS	2.32e-05	196	20	4	2036_DN
Drug	Carcinine [56897-53-1]; Down 200; 22uM; MCF7; HT_HG-U133A	SS18 CAT YIPF5 FUS	2.41e-05	198	20	4	4809_DN
Drug	O-(biotinylcarbazoylmethyl) hydroxylamine	CAT TDG	2.63e-05	9	20	2	CID000083922
Drug	R A J	EWSR1 HNRNPUL1 DYRK2	3.61e-05	74	20	3	CID011497471
Drug	tempol	SYP CAT HNRNPUL1 DYRK2	3.70e-05	221	20	4	CID000137994
Drug	AC1NRAYK	SYP EWSR1	4.01e-05	11	20	2	CID005288161
Drug	thiodiglycol	CAT TDG	4.01e-05	11	20	2	CID000005447
Drug	cytosine glycol	CAT TDG	4.81e-05	12	20	2	CID000166830
Drug	caryophyllene	SYP CAT	6.63e-05	14	20	2	ctd:C024714
Drug	L-anserine	HRC CAT	8.73e-05	16	20	2	CID000011444
Drug	berberine	SYP CAT TDG FUS	9.29e-05	280	20	4	CID000002353
Drug	Pilocarpine	SYP HOXB1 CAT TDG	9.94e-05	285	20	4	ctd:D010862
Drug	Acetic Acid	EOMES SYP CAT	1.03e-04	105	20	3	ctd:D019342
Drug	Endocrine Disruptors	TNS2 CAT TDG	1.18e-04	110	20	3	ctd:D052244
Drug	MPCA	CAT TDG	1.83e-04	23	20	2	CID000031060
Drug	8-oxyguanine	CAT TDG FUS	1.93e-04	130	20	3	CID000119315
Drug	POBN	CAT TDG	2.17e-04	25	20	2	CID000092375
Drug	Trichlorfon	SYP CAT	2.17e-04	25	20	2	ctd:D014236
Drug	HMdU	CAT TDG	2.17e-04	25	20	2	CID000091541
Drug	5'-TG-3	CAT TDG	2.35e-04	26	20	2	CID000482133
Drug	dialuric acid	CAT TDG	2.35e-04	26	20	2	CID000067956
Drug	benzo(a)pyrene	CAT FUS HNRNPUL1 DYRK2	2.39e-04	358	20	4	CID000002336
Drug	2H1H	EWSR1 FUS	2.73e-04	28	20	2	CID011527397
Drug	8-hydroxyadenine	CAT TDG	2.73e-04	28	20	2	CID005355054
Drug	Citric Acid	SYP CAT	2.93e-04	29	20	2	ctd:D019343
Drug	O-Nb	SYP EWSR1	3.14e-04	30	20	2	CID000006829
Drug	AC1L1AUZ	HNRNPAB EWSR1 FUS	3.36e-04	157	20	3	CID000001160
Drug	8-oxoG	CAT TDG	3.58e-04	32	20	2	CID000065131
Drug	FapyAde	CAT TDG	3.81e-04	33	20	2	CID000114926
Drug	EMCs	EWSR1 FUS	4.04e-04	34	20	2	CID005091655
Drug	hafnium oxide	CAT TDG	4.29e-04	35	20	2	CID000292779
Drug	profenofos	ARID1A CAT	4.54e-04	36	20	2	ctd:C024273
Drug	AC1NRA5C	HNRNPAB EWSR1 FUS	4.54e-04	174	20	3	CID005287709
Drug	histidinate	HRC HOXB1 CAT	4.54e-04	174	20	3	CID000000773
Drug	14-deoxy-11,12-didehydroandrographolide	EWSR1 YIPF5 FUS	4.62e-04	175	20	3	ctd:C495626
Drug	allantoin	CAT FUS	4.79e-04	37	20	2	CID000000204
Drug	Nivalenol hydrate	HRC FUS	5.06e-04	38	20	2	CID000031829
Drug	Camptothecine (S,+) [7689-03-4]; Down 200; 11.4uM; MCF7; HT_HG-U133A	ARID1A KANK1 DYRK2	5.35e-04	184	20	3	2321_DN
Drug	nitroxyl	CAT HNRNPUL1 DYRK2	5.43e-04	185	20	3	CID000000945
Drug	AC1L1B55	HNRNPAB CAT EWSR1 FUS	5.87e-04	454	20	4	CID000001287
Drug	PF-00562151-00 [351320-12-2]; Down 200; 10uM; MCF7; HT_HG-U133A	NDRG3 CAT FUS	5.87e-04	190	20	3	6912_DN
Drug	retinoic acid; Down 200; 1uM; MCF7; HT_HG-U133A	SS18 YIPF5 FUS	5.87e-04	190	20	3	1636_DN
Drug	sivelestat	BET1 CAT	5.89e-04	41	20	2	CID000107706
Drug	0297417-0002B [362658-29-5]; Down 200; 10uM; MCF7; HT_HG-U133A	NDRG3 TNS2 FUS	5.96e-04	191	20	3	6900_DN
Drug	Diphenylpyraline hydrochloride [132-18-3]; Down 200; 12.6uM; PC3; HT_HG-U133A	SS18 YIPF5 FUS	5.96e-04	191	20	3	4299_DN
Drug	PNU-0293363 [326823-19-2]; Up 200; 10uM; MCF7; HT_HG-U133A	CAT YIPF5 FUS	6.05e-04	192	20	3	6573_UP
Drug	2-propylpentanoic acid; Down 200; 50uM; MCF7; HT_HG-U133A	ARID1A SS18 YIPF5	6.05e-04	192	20	3	1647_DN
Drug	Oxolinic acid [14698-29-4]; Down 200; 15.4uM; HL60; HG-U133A	ARID1A NDRG3 HNRNPUL1	6.05e-04	192	20	3	1419_DN
Drug	CP-690334-01 [459212-38-5]; Down 200; 10uM; MCF7; HT_HG-U133A	TNS2 FUS DYRK2	6.15e-04	193	20	3	3906_DN
Drug	Fusidic Acid-d6	CAT FUS	6.18e-04	42	20	2	CID000003443
Drug	PM 2	HOXB1 CAT	6.18e-04	42	20	2	CID000657077
Drug	Azaguanine-8 [134-58-7]; Down 200; 26.2uM; MCF7; HT_HG-U133A	SS18 KANK1 DYRK2	6.24e-04	194	20	3	1670_DN
Drug	Graveoline [485-61-0]; Down 200; 14.4uM; MCF7; HT_HG-U133A	ARID1A NDRG3 TNS2	6.24e-04	194	20	3	4738_DN
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A	SS18 YIPF5 FUS	6.24e-04	194	20	3	5017_DN
Drug	Captopril [62571-86-2]; Down 200; 17.2uM; HL60; HG-U133A	CAT YIPF5 FUS	6.24e-04	194	20	3	1988_DN
Drug	Bepridil hydrochloride [74764-40-2]; Up 200; 10uM; HL60; HT_HG-U133A	ARID1A SS18 TNS2	6.24e-04	194	20	3	1274_UP
Drug	Domperidone maleate; Down 200; 7.4uM; MCF7; HT_HG-U133A	SS18 YIPF5 FUS	6.24e-04	194	20	3	2655_DN
Drug	Sulindac [38194-50-2]; Up 200; 11.2uM; PC3; HT_HG-U133A	NDRG3 SS18 TNS2	6.33e-04	195	20	3	1815_UP
Drug	Chlorpropamide [94-20-2]; Down 200; 14.4uM; MCF7; HT_HG-U133A	CAT YIPF5 FUS	6.33e-04	195	20	3	3210_DN
Drug	Benfluorex hydrochloride [23642-66-2]; Down 200; 10.4uM; MCF7; HT_HG-U133A	NDRG3 SS18 FUS	6.33e-04	195	20	3	5327_DN
Drug	Disopyramide [3737-09-5]; Down 200; 11.8uM; MCF7; HT_HG-U133A	SS18 YIPF5 FUS	6.33e-04	195	20	3	7035_DN
Drug	pioglitazone HCl; Down 200; 10uM; MCF7; HT_HG-U133A	SS18 YIPF5 FUS	6.43e-04	196	20	3	7083_DN
Drug	Orlistat; Down 200; 10uM; MCF7; HT_HG-U133A	NDRG3 SS18 FUS	6.43e-04	196	20	3	6905_DN
Drug	16, 16-dimethylprostaglandin E2 methyl acetate solution; Down 200; 10uM; PC3; HT_HG-U133A	SS18 YIPF5 FUS	6.43e-04	196	20	3	6562_DN
Drug	Letrozole [112809-51-5]; Up 200; 14uM; MCF7; HT_HG-U133A	SS18 CAT YIPF5	6.43e-04	196	20	3	4824_UP
Drug	EF-T	SYP EWSR1	6.48e-04	43	20	2	CID003054237
Drug	Desipramine hydrochloride [58-28-6]; Down 200; 13.2uM; MCF7; HT_HG-U133A	ARID1A SS18 FUS	6.52e-04	197	20	3	5292_DN
Drug	Butirosin disulfate salt [51022-98-1]; Down 200; 5.4uM; HL60; HT_HG-U133A	NDRG3 SS18 TNS2	6.52e-04	197	20	3	2518_DN
Drug	SB 202190; Down 200; 1uM; MCF7; HT_HG-U133A	ARID1A NDRG3 SS18	6.52e-04	197	20	3	6909_DN
Drug	5194442; Down 200; 20uM; MCF7; HT_HG-U133A	SS18 YIPF5 FUS	6.52e-04	197	20	3	6558_DN
Drug	Cephapirin sodium salt [24356-60-3]; Down 200; 9uM; MCF7; HT_HG-U133A	DAZAP1 SS18 TNS2	6.62e-04	198	20	3	6790_DN
Drug	Zidovudine, AZT [30516-87-1]; Down 200; 15uM; HL60; HG-U133A	NDRG3 KANK1 DYRK2	6.62e-04	198	20	3	1595_DN
Drug	novobiocin sodium, USP; Down 200; 100uM; MCF7; HG-U133A	CAT HNRNPUL1 DYRK2	6.62e-04	198	20	3	576_DN
Drug	Biperiden hydrochloride [1235-82-1]; Up 200; 11.4uM; HL60; HT_HG-U133A	NDRG3 SS18 KANK1	6.62e-04	198	20	3	2460_UP
Drug	Decamethonium bromide [541-22-0]; Down 200; 9.6uM; HL60; HT_HG-U133A	ARID1A NDRG3 DYRK2	6.72e-04	199	20	3	2933_DN
Drug	Molindone hydrochloride [15622-65-8]; Down 200; 12.8uM; MCF7; HT_HG-U133A	NDRG3 TNS2 DYRK2	6.72e-04	199	20	3	7337_DN
Drug	Moroxidine hydrochloride [3160-91-6]; Down 200; 19.2uM; HL60; HG-U133A	ARID1A HNRNPUL1 DYRK2	6.82e-04	200	20	3	2027_DN
Drug	formamidopyrimidine	CAT TDG	7.09e-04	45	20	2	CID000535165
Drug	AC1L97HB	CAT FUS	7.09e-04	45	20	2	CID000439504
Drug	AC1LA6XC	CAT TDG	7.09e-04	45	20	2	CID000482573
Drug	o-nitrophenyl beta-glucoside	CAT TDG	8.07e-04	48	20	2	CID000092941
Drug	D-salicin	CAT TDG	8.41e-04	49	20	2	CID000005145
Drug	N-tert-butyl-a-phenylnitrone	CAT TDG	8.41e-04	49	20	2	CID000004390
Drug	Nor 3	EWSR1 FUS	8.76e-04	50	20	2	CID009578441
Drug	8-oxo-dGTP	CAT TDG	8.76e-04	50	20	2	CID000107902
Drug	2,3,6-TBA	CAT FUS	8.76e-04	50	20	2	CID000005759
Disease	amyotrophic lateral sclerosis type 6 (implicated_via_orthology)	EWSR1 FUS	1.31e-06	3	20	2	DOID:0060198 (implicated_via_orthology)
Disease	frontotemporal dementia (implicated_via_orthology)	EWSR1 FUS	2.87e-05	12	20	2	DOID:9255 (implicated_via_orthology)
Disease	Nephrotic Syndrome	TNS2 KANK1	1.52e-04	27	20	2	C0027726
Disease	gastric adenocarcinoma (is_marker_for)	ARID1A CAT	1.63e-04	28	20	2	DOID:3717 (is_marker_for)
Disease	amyotrophic lateral sclerosis (implicated_via_orthology)	EWSR1 FUS	1.88e-04	30	20	2	DOID:332 (implicated_via_orthology)
Disease	hepatocellular carcinoma (is_implicated_in)	ARID1A HNRNPAB CAT	2.40e-04	181	20	3	DOID:684 (is_implicated_in)
Disease	Malignant neoplasm of breast	EOMES DAZAP1 ARID1A CAT FUS	6.22e-04	1074	20	5	C0006142
Disease	Amyotrophic Lateral Sclerosis	EWSR1 FUS	7.05e-04	58	20	2	C0002736
Disease	Cholestasis	CAT KANK1	2.50e-03	110	20	2	C0008370
Disease	Malignant Neoplasms	ARID1A CAT	3.37e-03	128	20	2	C0006826

Protein segments in the cluster

Peptide	Gene	Start	Entry
PGYEAAYGGAYGENP	TDG	336	Q13569
LGEGVPPGNYGNYGY	BET1	6	O15155
PPGNYGNYGYANSGY	BET1	11	O15155
GGYNQPSLGYGQSNY	EWSR1	156	Q01844
GGPGTYQYSQGAPLY	EOMES	226	O95936
DNQGGAPNYYPNSFG	CAT	396	P04040
QPDFPYGQYAGYGQD	DAZAP1	341	Q96EP5
GGGQYFAKPQNQGGY	HNRNPA1L2	291	Q32P51
YGPQGGQYGPQGGYP	ARID1A	796	O14497
GQQEGAPSFPTGYQY	NDRG3	96	Q9UGV2
RGLTGNYYPGPGNYG	LEXM	156	Q3ZCV2
NYYPGPGNYGEKGNP	LEXM	161	Q3ZCV2
TQSYGAYPTQPGQGY	FUS	11	P35637
YQGNGDYGSYAPAAP	KANK1	216	Q14678
SQYYPLGQSEGDGGY	HOXB1	96	P14653
GGPNNGGYDDDQGSY	DYRK2	196	Q92630
SYSQPPYNQGGYSQG	HNRNPUL1	756	Q9BUJ2
GYGPQDSYGPQGGYQ	SYP	261	P08247
DSYGPQGGYQPDYGQ	SYP	266	P08247
GSGYGPQGDYGQQGY	SYP	286	P08247
PQGDYGQQGYGPQGA	SYP	291	P08247
WNQGYGYQQGYGPGY	HNRNPAB	276	Q99729
GPQDAQEYGNYQPGS	HRC	611	P23327
QGYPGQQQGYGPSQG	SS18	356	Q15532
QSQQSYDYGGSGGPY	YIPF5	21	Q969M3
QGYREPCGVPNGGYY	TNS2	596	Q63HR2