Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	nuclear receptor coactivator activity	CALCOCO1 ETS1 ACTN4 ACTN1	5.23e-05	61	67	4	GO:0030374
Domain	ING	ING5 ING4	1.26e-04	5	67	2	SM01408
Domain	ING_N_histone_binding	ING5 ING4	1.26e-04	5	67	2	IPR024610
Domain	ING	ING5 ING4	1.26e-04	5	67	2	PF12998
Domain	ING_fam	ING5 ING4	1.26e-04	5	67	2	IPR028651
Domain	EF-hand_Ca_insen	ACTN4 ACTN1	1.88e-04	6	67	2	IPR014837
Domain	EFhand_Ca_insen	ACTN4 ACTN1	1.88e-04	6	67	2	PF08726
Domain	RECEPTOR_TYR_KIN_V_2	EPHB2 EPHA5	1.12e-03	14	67	2	PS00791
Domain	RECEPTOR_TYR_KIN_V_1	EPHB2 EPHA5	1.12e-03	14	67	2	PS00790
Domain	Eph_TM	EPHB2 EPHA5	1.12e-03	14	67	2	IPR027936
Domain	Tyr_kinase_rcpt_V_CS	EPHB2 EPHA5	1.12e-03	14	67	2	IPR001426
Domain	EPH_lbd	EPHB2 EPHA5	1.12e-03	14	67	2	SM00615
Domain	Ephrin_lbd	EPHB2 EPHA5	1.12e-03	14	67	2	PF01404
Domain	EphA2_TM	EPHB2 EPHA5	1.12e-03	14	67	2	PF14575
Domain	Tyr_kinase_ephrin_rcpt	EPHB2 EPHA5	1.12e-03	14	67	2	IPR016257
Domain	Ephrin_rcpt_lig-bd_dom	EPHB2 EPHA5	1.12e-03	14	67	2	IPR001090
Domain	EPH_LBD	EPHB2 EPHA5	1.12e-03	14	67	2	PS51550
Domain	Znf_FYVE_PHD	ANKFY1 BAZ2B ING5 ING4	1.92e-03	147	67	4	IPR011011
Domain	PHD	BAZ2B ING5 ING4	2.48e-03	75	67	3	PF00628
Domain	Znf_PHD-finger	BAZ2B ING5 ING4	2.87e-03	79	67	3	IPR019787
Domain	Actinin_actin-bd_CS	ACTN4 ACTN1	3.06e-03	23	67	2	IPR001589
Domain	Spectrin	ACTN4 ACTN1	3.06e-03	23	67	2	PF00435
Domain	ACTININ_2	ACTN4 ACTN1	3.06e-03	23	67	2	PS00020
Domain	ACTININ_1	ACTN4 ACTN1	3.06e-03	23	67	2	PS00019
Domain	Ephrin_rec_like	EPHB2 EPHA5	3.61e-03	25	67	2	SM01411
Domain	Tyr-kin_ephrin_A/B_rcpt-like	EPHB2 EPHA5	3.61e-03	25	67	2	IPR011641
Domain	PHD	BAZ2B ING5 ING4	4.02e-03	89	67	3	SM00249
Domain	Znf_PHD	BAZ2B ING5 ING4	4.28e-03	91	67	3	IPR001965
Domain	ZF_PHD_2	BAZ2B ING5 ING4	4.83e-03	95	67	3	PS50016
Domain	Spectrin_repeat	ACTN4 ACTN1	4.84e-03	29	67	2	IPR002017
Domain	ZF_PHD_1	BAZ2B ING5 ING4	4.97e-03	96	67	3	PS01359
Domain	-	TRAF7 ANKFY1 BAZ2B ING5 VPS41 ING4	5.41e-03	449	67	6	3.30.40.10
Domain	Spectrin/alpha-actinin	ACTN4 ACTN1	5.87e-03	32	67	2	IPR018159
Domain	SPEC	ACTN4 ACTN1	5.87e-03	32	67	2	SM00150
Domain	Znf_RING/FYVE/PHD	TRAF7 ANKFY1 BAZ2B ING5 VPS41 ING4	6.01e-03	459	67	6	IPR013083
Domain	-	EPHB2 ETS1 EPHA5	6.54e-03	106	67	3	1.10.150.50
Domain	SAM/pointed	EPHB2 ETS1 EPHA5	8.58e-03	117	67	3	IPR013761
Pathway	KEGG_MEDICUS_REFERENCE_HEDGEHOG_SIGNALING_PATHWAY	GLI1 EVC PTCH1	1.31e-05	14	48	3	M47414
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_PTCH1_TO_HEDGEHOG_SIGNALING_PATHWAY	GLI1 WNT4 PTCH1	1.27e-04	29	48	3	M47372
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_SMO_TO_HEDGEHOG_SIGNALING_PATHWAY	GLI1 WNT4 PTCH1	1.27e-04	29	48	3	M47377
Pathway	REACTOME_GLI_PROTEINS_BIND_PROMOTERS_OF_HH_RESPONSIVE_GENES_TO_PROMOTE_TRANSCRIPTION	GLI1 PTCH1	2.36e-04	7	48	2	M27501
Pubmed	Evc regulates a symmetrical response to Shh signaling in molar development.	GLI1 EVC PTCH1	8.12e-07	10	67	3	23315474
Pubmed	Evc is a positive mediator of Ihh-regulated bone growth that localises at the base of chondrocyte cilia.	GLI1 EVC PTCH1	1.48e-06	12	67	3	17660199
Pubmed	Overexpression of mutant Ptch in rhabdomyosarcomas is associated with promoter hypomethylation and increased Gli1 and H3K4me3 occupancy.	GLI1 PTCH1	3.66e-06	2	67	2	25823816
Pubmed	Distinct forms of the actin cross-linking protein α-actinin support macropinosome internalization and trafficking.	ACTN4 ACTN1	3.66e-06	2	67	2	34010028
Pubmed	Correlation of hedgehog signal activation with chemoradiotherapy sensitivity and survival in esophageal squamous cell carcinomas.	GLI1 PTCH1	3.66e-06	2	67	2	21127038
Pubmed	An analysis of splicing, actin-binding properties, heterodimerization and molecular interactions of the non-muscle α-actinins.	ACTN4 ACTN1	3.66e-06	2	67	2	23557398
Pubmed	Isoform-specific contributions of alpha-actinin to glioma cell mechanobiology.	ACTN4 ACTN1	3.66e-06	2	67	2	20037648
Pubmed	Unusual binding interactions in PDZ domain crystal structures help explain binding mechanisms.	ACTN1 PDLIM4	3.66e-06	2	67	2	20120020
Pubmed	HAMLET binding to α-actinin facilitates tumor cell detachment.	ACTN4 ACTN1	3.66e-06	2	67	2	21408150
Pubmed	Gli1/DNA interaction is a druggable target for Hedgehog-dependent tumors.	GLI1 PTCH1	3.66e-06	2	67	2	25476449
Pubmed	Actinin-1 and actinin-4 play essential but distinct roles in invadopodia formation by carcinoma cells.	ACTN4 ACTN1	3.66e-06	2	67	2	28797528
Pubmed	α-actinin1 and 4 tyrosine phosphorylation is critical for stress fiber establishment, maintenance and focal adhesion maturation.	ACTN4 ACTN1	3.66e-06	2	67	2	23454549
Pubmed	Lack of evidence for activation of the hedgehog pathway in psoriasis.	GLI1 PTCH1	3.66e-06	2	67	2	18754037
Pubmed	Hedgehog pathway activity in pediatric embryonal rhabdomyosarcoma and undifferentiated sarcoma: a report from the Children's Oncology Group.	GLI1 PTCH1	3.66e-06	2	67	2	21618411
Pubmed	Alpha-actinin 1 and alpha-actinin 4: contrasting roles in the survival, motility, and RhoA signaling of astrocytoma cells.	ACTN4 ACTN1	3.66e-06	2	67	2	20156433
Pubmed	High expression of patched homolog-1 messenger RNA and glioma-associated oncogene-1 messenger RNA of sonic hedgehog signaling pathway indicates a risk of postresection recurrence of hepatocellular carcinoma.	GLI1 PTCH1	3.66e-06	2	67	2	22911366
Pubmed	Inhibition of GLI1 gene activation by Patched1.	GLI1 PTCH1	3.66e-06	2	67	2	16229683
Pubmed	Deficiency of patched 1-induced Gli1 signal transduction results in astrogenesis in Swedish mutated APP transgenic mice.	GLI1 PTCH1	3.66e-06	2	67	2	25027328
Pubmed	Kif3a controls murine nephron number via GLI3 repressor, cell survival, and gene expression in a lineage-specific manner.	GLI1 WNT4 PTCH1	3.76e-06	16	67	3	23762375
Pubmed	The ciliary Evc/Evc2 complex interacts with Smo and controls Hedgehog pathway activity in chondrocytes by regulating Sufu/Gli3 dissociation and Gli3 trafficking in primary cilia.	GLI1 EVC PTCH1	3.76e-06	16	67	3	23026747
Pubmed	Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis.	EPHB2 MAP2K4 EPHA5	3.76e-06	16	67	3	8755474
Pubmed	Primary cilia function regulates the length of the embryonic trunk axis and urogenital field in mice.	GLI1 WNT4 PTCH1	1.03e-05	22	67	3	25224227
Pubmed	Elevated Fibroblast Growth Factor Signaling Is Critical for the Pathogenesis of the Dwarfism in Evc2/Limbin Mutant Mice.	EPHB2 GLI1 PTCH1	1.03e-05	22	67	3	28027321
Pubmed	Rhabdomyosarcomas and radiation hypersensitivity in a mouse model of Gorlin syndrome.	GLI1 PTCH1	1.10e-05	3	67	2	9585239
Pubmed	Activation of hedgehog signaling pathway in human non-small cell lung cancers.	GLI1 PTCH1	1.10e-05	3	67	2	24710823
Pubmed	Differential binding of cross-reactive anti-DNA antibodies to mesangial cells: the role of alpha-actinin.	ACTN4 ACTN1	1.10e-05	3	67	2	16751418
Pubmed	Hedgehog pathway as a potential treatment target in human cholangiocarcinoma.	GLI1 PTCH1	1.10e-05	3	67	2	24733827
Pubmed	α-Actinin-3 deficiency is associated with reduced bone mass in human and mouse.	ACTN4 ACTN1	1.10e-05	3	67	2	21784188
Pubmed	Frequent activation of the hedgehog pathway in advanced gastric adenocarcinomas.	GLI1 PTCH1	1.10e-05	3	67	2	15905200
Pubmed	Immunohistochemical evidence of the prognostic value of hedgehog pathway components in primary gallbladder carcinoma.	GLI1 PTCH1	1.10e-05	3	67	2	22407314
Pubmed	Identification of ocular regulatory functions of core histone variant H3.2.	EPHB2 EPHA5	1.10e-05	3	67	2	36529279
Pubmed	EBNA3C attenuates the function of p53 through interaction with inhibitor of growth family proteins 4 and 5.	ING5 ING4	1.10e-05	3	67	2	21177815
Pubmed	Hair cycle regulation of Hedgehog signal reception.	GLI1 PTCH1	1.10e-05	3	67	2	12648487
Pubmed	Junctional Rab13-binding protein (JRAB) regulates cell spreading via filamins.	ACTN4 ACTN1	1.10e-05	3	67	2	23890175
Pubmed	Expression of hedgehog pathway components is associated with bladder cancer progression and clinical outcome.	GLI1 PTCH1	1.10e-05	3	67	2	21861243
Pubmed	Sonic hedgehog promotes the migration and proliferation of optic nerve oligodendrocyte precursors.	GLI1 PTCH1	1.10e-05	3	67	2	17826177
Pubmed	Stromal Hedgehog signalling is downregulated in colon cancer and its restoration restrains tumour growth.	GLI1 PTCH1	1.10e-05	3	67	2	27492255
Pubmed	Hedgehog signaling pathway and vitamin D receptor gene variants as potential risk factors in odontogenic cystic lesions.	GLI1 PTCH1	1.10e-05	3	67	2	30334169
Pubmed	Altered canonical hedgehog-gli signalling axis in pesticide-induced bone marrow aplasia mouse model.	GLI1 PTCH1	1.10e-05	3	67	2	23152377
Pubmed	Sonic hedgehog-Gli1 pathway in colorectal adenocarcinomas.	GLI1 PTCH1	1.10e-05	3	67	2	17461467
Pubmed	Gli1 is important for medulloblastoma formation in Ptc1+/- mice.	GLI1 PTCH1	1.10e-05	3	67	2	15806168
Pubmed	New insights into the GDF9-Hedgehog-GLI signaling pathway in human ovaries: from fetus to postmenopause.	GLI1 PTCH1	1.10e-05	3	67	2	33772413
Pubmed	Prognostic value of hedgehog signaling pathway in patients with colon cancer.	GLI1 PTCH1	1.10e-05	3	67	2	21424326
Pubmed	Hedgehog signaling pathway in neuroblastoma differentiation.	GLI1 PTCH1	1.10e-05	3	67	2	21129534
Pubmed	A synaptic F-actin network controls otoferlin-dependent exocytosis in auditory inner hair cells.	OTOF ACTN1	1.10e-05	3	67	2	26568308
Pubmed	Sonic hedgehog signalling inhibits palatogenesis and arrests tooth development in a mouse model of the nevoid basal cell carcinoma syndrome.	GLI1 PTCH1	1.10e-05	3	67	2	19394325
Pubmed	Evidence of a functional role for interaction between ICAM-1 and nonmuscle alpha-actinins in leukocyte diapedesis.	ACTN4 ACTN1	1.10e-05	3	67	2	16951376
Pubmed	Activation of hedgehog signaling in mesenchymal stem cells induces cartilage and bone tumor formation via Wnt/β-Catenin.	GLI1 PTCH1	1.10e-05	3	67	2	31482846
Pubmed	Aberrant expression of Sonic hedgehog signaling in Peutz-Jeghers syndrome.	GLI1 PTCH1	1.10e-05	3	67	2	26997450
Pubmed	Patched target Igf2 is indispensable for the formation of medulloblastoma and rhabdomyosarcoma.	GLI1 PTCH1	1.10e-05	3	67	2	10884376
Pubmed	Dosage-dependent hedgehog signals integrated with Wnt/beta-catenin signaling regulate external genitalia formation as an appendicular program.	GLI1 WNT4 PTCH1	1.18e-05	23	67	3	19906864
Pubmed	Primary cilia in murine palatal rugae development.	GLI1 WNT4 PTCH1	1.18e-05	23	67	3	31226309
Pubmed	Pathological responses to oncogenic Hedgehog signaling in skin are dependent on canonical Wnt/beta3-catenin signaling.	GLI1 WNT4 PTCH1	1.34e-05	24	67	3	19165927
Pubmed	Atmin mediates kidney morphogenesis by modulating Wnt signaling.	GLI1 WNT4 PTCH1	1.34e-05	24	67	3	24852369
Pubmed	Cilia gene mutations cause atrioventricular septal defects by multiple mechanisms.	GLI1 EVC PTCH1	1.52e-05	25	67	3	27340223
Pubmed	The prognostic significance and therapeutic potential of hedgehog signaling in intrahepatic cholangiocellular carcinoma.	GLI1 PTCH1	2.19e-05	4	67	2	23493353
Pubmed	Hedgehog signaling in neonatal and adult lung.	GLI1 PTCH1	2.19e-05	4	67	2	23371063
Pubmed	cDNA cloning and tissue distribution of five human EPH-like receptor protein-tyrosine kinases.	EPHB2 EPHA5	2.19e-05	4	67	2	7898931
Pubmed	Immunohistochemical expression of SHH, PTC, SMO and GLI1 in glandular odontogenic cysts and dentigerous cysts.	GLI1 PTCH1	2.19e-05	4	67	2	20561215
Pubmed	Persistent sonic hedgehog signaling in adult brain determines neural stem cell positional identity.	GLI1 PTCH1	2.19e-05	4	67	2	21791285
Pubmed	Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer.	GLI1 PTCH1	2.19e-05	4	67	2	12629553
Pubmed	Estradiol triggers sonic-hedgehog-induced angiogenesis during peripheral nerve regeneration by downregulating hedgehog-interacting protein.	GLI1 PTCH1	2.19e-05	4	67	2	22330336
Pubmed	Genetic evidence that Sil is required for the Sonic Hedgehog response pathway.	GLI1 PTCH1	2.19e-05	4	67	2	11668681
Pubmed	Hbo1 Links p53-dependent stress signaling to DNA replication licensing.	ING5 ING4	2.19e-05	4	67	2	17954561
Pubmed	Integrin-dependent force transmission to the extracellular matrix by α-actinin triggers adhesion maturation.	ACTN4 ACTN1	2.19e-05	4	67	2	23515331
Pubmed	Generation of Evc2/Limbin global and conditional KO mice and its roles during mineralized tissue formation.	GLI1 PTCH1	2.19e-05	4	67	2	26219237
Pubmed	Alpha-actinin and vinculin in human neutrophils: reorganization during adhesion and relation to the actin network.	ACTN4 ACTN1	2.19e-05	4	67	2	1629252
Pubmed	An interaction between alpha-actinin and the beta 1 integrin subunit in vitro.	ACTN4 ACTN1	2.19e-05	4	67	2	2116421
Pubmed	p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity.	ING5 ING4	2.19e-05	4	67	2	12750254
Pubmed	Gas1 is a modifier for holoprosencephaly and genetically interacts with sonic hedgehog.	GLI1 PTCH1	2.19e-05	4	67	2	17525797
Pubmed	SHH Protein Variance in the Limb Bud Is Constrained by Feedback Regulation and Correlates with Altered Digit Patterning.	GLI1 PTCH1	2.19e-05	4	67	2	28131983
Pubmed	HAN11 binds mDia1 and controls GLI1 transcriptional activity.	GLI1 PTCH1	2.19e-05	4	67	2	16887337
Pubmed	Familial focal segmental glomerulosclerosis (FSGS)-linked α-actinin 4 (ACTN4) protein mutants lose ability to activate transcription by nuclear hormone receptors.	ACTN4 ACTN1	2.19e-05	4	67	2	22351778
Pubmed	TLR7 mediated viral recognition results in focal type I interferon secretion by dendritic cells.	PLEKHM2 ITGAL	2.19e-05	4	67	2	29150602
Pubmed	CLP-36 PDZ-LIM protein associates with nonmuscle alpha-actinin-1 and alpha-actinin-4.	ACTN4 ACTN1	2.19e-05	4	67	2	10753915
Pubmed	Disruption of alpha-actinin-integrin interactions at focal adhesions renders osteoblasts susceptible to apoptosis.	ACTN4 ACTN1	2.19e-05	4	67	2	16807302
Pubmed	The immunoprofile of odontogenic keratocyst (keratocystic odontogenic tumor) that includes expression of PTCH, SMO, GLI-1 and bcl-2 is similar to ameloblastoma but different from odontogenic cysts.	GLI1 PTCH1	2.19e-05	4	67	2	19473442
Pubmed	LAP2 Proteins Chaperone GLI1 Movement between the Lamina and Chromatin to Regulate Transcription.	GLI1 PTCH1	2.19e-05	4	67	2	30503211
Pubmed	Interactions of a hemidesmosome component and actinin family members.	ACTN4 ACTN1	2.19e-05	4	67	2	11739652
Pubmed	A Distinct Malignant Epithelioid Neoplasm With GLI1 Gene Rearrangements, Frequent S100 Protein Expression, and Metastatic Potential: Expanding the Spectrum of Pathologic Entities With ACTB/MALAT1/PTCH1-GLI1 Fusions.	GLI1 PTCH1	2.19e-05	4	67	2	29309307
Pubmed	Structural dynamics of alpha-actinin-vinculin interactions.	ACTN4 ACTN1	2.19e-05	4	67	2	15988023
Pubmed	A class I PI3K signalling network regulates primary cilia disassembly in normal physiology and disease.	GLI1 PTCH1	2.19e-05	4	67	2	39168978
Pubmed	Tbx5-hedgehog molecular networks are essential in the second heart field for atrial septation.	ANAPC1 GLI1 PTCH1	2.41e-05	29	67	3	22898775
Pubmed	Primary cilia and Gli3 activity regulate cerebral cortical size.	EPHB2 GLI1 PTCH1	2.41e-05	29	67	3	21976438
Pubmed	Evc works in chondrocytes and osteoblasts to regulate multiple aspects of growth plate development in the appendicular skeleton and cranial base.	GLI1 EVC PTCH1	2.67e-05	30	67	3	21911092
Pubmed	Targeted Disruption of Lats1 and Lats2 in Mice Impairs Testis Development and Alters Somatic Cell Fate.	GLI1 WNT4 PTCH1	2.96e-05	31	67	3	36362374
Pubmed	Polycomb-Mediated Repression and Sonic Hedgehog Signaling Interact to Regulate Merkel Cell Specification during Skin Development.	GLI1 WNT4 PTCH1	3.58e-05	33	67	3	27414999
Pubmed	Sonic hedgehog regulates the proliferation, differentiation, and migration of enteric neural crest cells in gut.	GLI1 PTCH1	3.64e-05	5	67	2	15337776
Pubmed	Sonic hedgehog signaling regulates the expression of insulin-like growth factor binding protein-6 during fetal prostate development.	GLI1 PTCH1	3.64e-05	5	67	2	15906375
Pubmed	Evidence for the involvement of the Gli gene family in embryonic mouse lung development.	GLI1 PTCH1	3.64e-05	5	67	2	9268579
Pubmed	Genetic interactions between the hedgehog co-receptors Gas1 and Boc regulate cell proliferation during murine palatogenesis.	GLI1 PTCH1	3.64e-05	5	67	2	27811357
Pubmed	Attenuation of cardiac remodeling after myocardial infarction by muscle LIM protein-calcineurin signaling at the sarcomeric Z-disc.	PPP3CA ACTN1	3.64e-05	5	67	2	15665106
Pubmed	Msx1 is required for the induction of Patched by Sonic hedgehog in the mammalian tooth germ.	GLI1 PTCH1	3.64e-05	5	67	2	10340755
Pubmed	Sequential activation of Snail1 and N-Myc modulates sonic hedgehog-induced transformation of neural cells.	GLI1 PTCH1	3.64e-05	5	67	2	21646478
Pubmed	Expression of Sonic Hedgehog and pathway components in the embryonic mouse head: anatomical relationships between regulators of positive and negative feedback.	GLI1 PTCH1	3.64e-05	5	67	2	34353359
Pubmed	Hedgehog-responsive mesenchymal clusters direct patterning and emergence of intestinal villi.	GLI1 PTCH1	3.64e-05	5	67	2	23019366
Pubmed	Synaptopodin regulates the actin-bundling activity of alpha-actinin in an isoform-specific manner.	ACTN4 ACTN1	3.64e-05	5	67	2	15841212
Pubmed	Inactivation of Patched1 in the mouse limb has novel inhibitory effects on the chondrogenic program.	GLI1 PTCH1	3.64e-05	5	67	2	20576618
Pubmed	Conserved molecular interactions within the HBO1 acetyltransferase complexes regulate cell proliferation.	ING5 ING4	3.64e-05	5	67	2	22144582
Pubmed	The Adult Adrenal Cortex Undergoes Rapid Tissue Renewal in a Sex-Specific Manner.	GLI1 WNT4	3.64e-05	5	67	2	31104943
GeneFamily	Actinins	ACTN4 ACTN1	3.46e-05	4	44	2	1112
GeneFamily	Fibronectin type III domain containing\|Sterile alpha motif domain containing\|EPH receptors	EPHB2 EPHA5	5.17e-04	14	44	2	1095
GeneFamily	PHD finger proteins	BAZ2B ING5 ING4	1.36e-03	90	44	3	88
Coexpression	GSE9650_EXHAUSTED_VS_MEMORY_CD8_TCELL_DN	CCNDBP1 FCGR2B ETS1 RREB1 ITGAL ENTPD4	1.24e-05	200	67	6	M5841
Coexpression	LI_INDUCED_T_TO_NATURAL_KILLER_DN	TXNIP ETS1 ACTN1 PLEKHG2 PDLIM4	2.70e-05	137	67	5	M2088
Coexpression	LI_INDUCED_T_TO_NATURAL_KILLER_DN	TXNIP ETS1 ACTN1 PLEKHG2 PDLIM4	2.80e-05	138	67	5	MM882
ToppCell	10x_3'_v2v3-Non-neoplastic-Lymphoid-CD4/CD8-Reg_T-E\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	TXNIP BAIAP2L1 ETS1 GSDMB ITGAL	5.48e-06	168	67	5	187b98664843a304406f086ea696adbf32283d07
ToppCell	facs-Marrow-T-cells-3m-Hematologic-MPP_Fraction_B_+_C\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRGUK FUT10 ANKRD24 FAM83C ENTPD4	5.80e-06	170	67	5	d70aaa0f4e5034bb9f61b832b5f9123870936d3c
ToppCell	367C-Lymphocytic-NK_cells-NK_cell_B1\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	TRAF7 ANKFY1 CPSF6 VPS41 HPS3	1.02e-05	191	67	5	39ef8e1d7cc3ebb11717e8a55501515e3b72b177
ToppCell	COVID-19-COVID-19_Mild-Lymphocyte-T/NK-CD4+_T_activated\|COVID-19_Mild / Disease, condition lineage and cell class	CISH TXNIP LRRN3 ETS1 GSDMB	1.27e-05	200	67	5	d9e8a0d047d4403fb7265fde7448e23a7780785c
ToppCell	COVID-19-COVID-19_Mild-Lymphocyte-T/NK-NK_activated\|COVID-19_Mild / Disease, condition lineage and cell class	TXNIP ETS1 PTCH1 ITGAL CXCR1	1.27e-05	200	67	5	2281debd86e5d92e8fe0397aec9ef670800f7471
ToppCell	facs-Liver\|facs / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FCGR2B ETS1 PPP1R16B GC	9.45e-05	158	67	4	ea7db6bd9742153ceb6e444892a6d1df9c7fcc96
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L2/3_IT\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	PPP3CA OTOF EVC WNT4	1.02e-04	161	67	4	e3327c296d48e821004e61a573abb75624a6f040
ToppCell	PND28-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-CD8_T-CD8_T_prolif\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	THUMPD3 ING5 EVC PTCD3	1.09e-04	164	67	4	5621c2e3fae84d5a2e4f1595e454bcb3a2b3f93c
ToppCell	facs-Heart-RA-24m-Myeloid-monocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TBXAS1 FCGR2B ITGAL PDLIM4	1.14e-04	166	67	4	e868e90b5272da6ccfc1c371e1b1aac1d63c5139
ToppCell	facs-Heart-RA-24m-Myeloid\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TBXAS1 FCGR2B ITGAL PDLIM4	1.14e-04	166	67	4	af30d3fa9380056be17b0dc720c8be09418b5529
ToppCell	facs-Heart-RA-24m-Myeloid-monocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TBXAS1 FCGR2B ITGAL PDLIM4	1.14e-04	166	67	4	fb3daa5e5a6d9ecf52ef2e019258e84761e87b65
ToppCell	facs-Trachea-24m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l15\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	GC COX4I2 ENTPD4 TULP2	1.17e-04	167	67	4	55c3c68af269fcf40f2b080ae4489523609ad388
ToppCell	systemic_lupus_erythematosus-flare-Hematopoietic-Progen-male\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	CISH LRRN3 ETS1 MAP10	1.17e-04	167	67	4	b89ebd4906f52b1fe6b6540ec9339284e7caddd2
ToppCell	systemic_lupus_erythematosus-flare-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-male\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	LRRN3 BTBD18 ETS1 PTCH1	1.20e-04	168	67	4	b94b1f37c92e019d01ecfa3b7cc6797b6e4a56ff
ToppCell	facs-Liver-Hepatocytes-24m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TBXAS1 PLEKHM2 COX4I2 PDLIM4	1.20e-04	168	67	4	04e168fe1d6f5f9e3d3bf9d7c13e800e3594868a
ToppCell	facs-Liver-Non-hepatocytes-3m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TBXAS1 ACTN1 ITGAL PDLIM4	1.22e-04	169	67	4	44d841fd997a6f26104f16cd00223ecce8352f43
ToppCell	facs-Liver-Non-hepatocytes-3m-Myeloid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TBXAS1 ACTN1 ITGAL PDLIM4	1.22e-04	169	67	4	aec1b4c7e973a31c53aaea47c2c05d24ce16aa4f
ToppCell	droplet-Lung-nan-18m\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TXNIP ETS1 PPP1R16B CXCR1	1.22e-04	169	67	4	f0f97ca415aef619b8b4b1399ad5e0823267516e
ToppCell	droplet-Lung-18m\|Lung / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TXNIP ETS1 PPP1R16B CXCR1	1.25e-04	170	67	4	683c4aa74689791944b6f3998dba51a4456fbc49
ToppCell	metastatic_Brain-Fibroblasts-Undetermined\|Fibroblasts / Location, Cell class and cell subclass	TBXAS1 FUT10 PLEKHA6 PTCH1	1.31e-04	172	67	4	c3822ff7329c3ac38c68c5c38cd67c390682e2a6
ToppCell	droplet-Marrow-nan-3m-Myeloid-granulocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GLI1 ETS1 ACTN1 EPHA5	1.31e-04	172	67	4	d354424c1f861b6607dfd63b9724f4c237b30275
ToppCell	5'-Airway_Nasal-Immune_Lymphocytic-Lymphocytic_T/NK-natural_killer_cell-NK_cells\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ETS1 PPP1R16B ANKRD24 ITGAL	1.37e-04	174	67	4	7ebf06076946729c1af25109df6066731097c3b1
ToppCell	5'-Airway_Nasal-Immune_Lymphocytic-Lymphocytic_T/NK-natural_killer_cell-NK_cells-NK_cells_L.1.3.0.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ETS1 PPP1R16B ANKRD24 ITGAL	1.37e-04	174	67	4	90961e8839514985712b8b986aec3391bb249ba7
ToppCell	ASK452-Immune-NK_cell\|ASK452 / Donor, Lineage and Cell class of Lung cells from Dropseq	TXNIP ETS1 GSDMB ITGAL	1.37e-04	174	67	4	b84e6dc1c003a677234ce3a818650ff58a45dd09
ToppCell	droplet-Lung-18m-Hematologic-myeloid-interstitial_macrophage-interstitial_macrophage_l12\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TBXAS1 FCGR2B ESPL1 PDLIM4	1.37e-04	174	67	4	33e5903adb746f693433bdca11a75c508bbf50c0
ToppCell	5'-Airway_Nasal-Immune_Lymphocytic-Lymphocytic_T/NK-natural_killer_cell\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ETS1 PPP1R16B ANKRD24 ITGAL	1.37e-04	174	67	4	c4b0987d9394f977fe6bc6a4214a6d8d73d0abcc
ToppCell	normal_Lymph_Node-Myeloid_cells-pDCs\|Myeloid_cells / Location, Cell class and cell subclass	GSDMB PLEKHG2 COX4I2 ENTPD4	1.37e-04	174	67	4	2274648b80dd74f3c948a779bba3391095964c34
ToppCell	droplet-Lung-18m-Hematologic-myeloid-interstitial_macrophage\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TBXAS1 FCGR2B ESPL1 PDLIM4	1.37e-04	174	67	4	ca0c2f42544092848541863c4a47b334e6828b8a
ToppCell	droplet-Liver-Npc-18m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TBXAS1 PLEKHM2 ACTN1 ITGAL	1.40e-04	175	67	4	1973fff0d7e1a94b31f461a39b91cc7984ebd8f1
ToppCell	facs-SCAT-Fat-24m-Lymphocytic-NK_cell\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CISH LRRN3 ETS1 PPP1R16B	1.40e-04	175	67	4	d82153bdb0c5cca96485d6b0579440f9c9e3abe2
ToppCell	Striatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Drd1-Excitatory_Neuron.Gad1Gad2.Drd1-Lypd1_(dSPN,_patch)-\|Striatum / BrainAtlas - Mouse McCarroll V32	SCN11A BTBD18 GC	1.41e-04	67	67	3	45228b2a1e445ecba32820a282088fd0c4bb2929
ToppCell	Striatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Drd1-Excitatory_Neuron.Gad1Gad2.Drd1-Lypd1_(dSPN,_patch)\|Striatum / BrainAtlas - Mouse McCarroll V32	SCN11A BTBD18 GC	1.41e-04	67	67	3	4fb4381133cfc3a2d5b633eea76c4fc4ef051f08
ToppCell	metastatic_Brain-Myeloid_cells-Activated_DCs\|Myeloid_cells / Location, Cell class and cell subclass	AOC1 BAIAP2L1 PPP1R16B GSDMB	1.43e-04	176	67	4	9c1f255de3082b3da4bef2a9bdff710cfd48261f
ToppCell	droplet-Liver-Npc-18m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TBXAS1 PLEKHM2 ACTN1 ITGAL	1.43e-04	176	67	4	1e430dffddd315d9a1cb4bd7fef5077656351c65
ToppCell	5'-Adult-Appendix-Hematopoietic-T_cells-CX3CR1+_CD8_Tmem\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ETS1 PPP1R16B ITGAL CXCR1	1.43e-04	176	67	4	6b06da40eb97ea2db09f3a769494738b3e5fe3fa
ToppCell	facs-SCAT-Fat-3m-Lymphocytic-CD8-positive,_alpha-beta_T_cell\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ETS1 PPP1R16B ACTN1 ITGAL	1.46e-04	177	67	4	ffc4c675b25ffe8bd3441ce26dd0984fef4b3b88
ToppCell	356C-Lymphocytic-NK_cells-NK_cell_C\|356C / Donor, Lineage, Cell class and subclass (all cells)	TXNIP ETS1 ITGAL CXCR1	1.49e-04	178	67	4	7203149864cc8d5ae25329fdbf15c6b73c3d3595
ToppCell	droplet-Lung-LUNG-1m-Lymphocytic-CD4+_T\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TXNIP ETS1 ACTN1 PDLIM4	1.49e-04	178	67	4	cd0c5f15e6b28ce2208346279ee9503d18d9b27d
ToppCell	droplet-Lung-LUNG-1m-Lymphocytic-CD4-positive,_alpha-beta_T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TXNIP ETS1 ACTN1 PDLIM4	1.49e-04	178	67	4	813d121a45e0416de1f26862851f6f0bda7ba43c
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c02-GPR183\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	CISH LRRN3 ETS1 ACTN1	1.49e-04	178	67	4	31c847d7f7aa0f6d820afbb45d507992f5e9dc2f
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Neuronal-cardiac_neuron\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FCGR2B SRCIN1 TULP2 PDLIM4	1.56e-04	180	67	4	d9c9399df3e2d9f23dbbfffb6cbe8404bf01e2b7
ToppCell	Primary_Visual_cortex_(V1C)-Non-neuronal-Mesenchymal-Mes\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TXNIP ETS1 PLEKHG2 COX4I2	1.56e-04	180	67	4	1ade66352570a3f869e21e1055d0a65fbf56c61d
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Neuronal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FCGR2B SRCIN1 TULP2 PDLIM4	1.56e-04	180	67	4	dad458398683ff80a6e207bdc08e257d1bb757d6
ToppCell	Primary_Visual_cortex_(V1C)-Non-neuronal-Mesenchymal\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TXNIP ETS1 PLEKHG2 COX4I2	1.56e-04	180	67	4	f118c580134bdf3027e2218690cfc8a93468c1ae
ToppCell	LA-17._Lymphocyte\|LA / Chamber and Cluster_Paper	TBXAS1 ETS1 PPP1R16B ITGAL	1.59e-04	181	67	4	3fd9f805fa46141b0fa7023ee5d8688d338635d5
ToppCell	facs-GAT-Fat-3m-Lymphocytic-T_cell\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CISH ETS1 PPP1R16B ITGAL	1.63e-04	182	67	4	751bd3e3b49de961523e98197688a05c998c121a
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Neuronal-cardiac_neuron\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FCGR2B SRCIN1 TULP2 PDLIM4	1.63e-04	182	67	4	812ff2a50a510b18d865e89465dba1754a08ef61
ToppCell	Adult-Immune-natural_killer_cell-D231\|Adult / Lineage, Cell type, age group and donor	ETS1 PPP1R16B PTCH1 ITGAL	1.63e-04	182	67	4	dbf47bf4754d8ec3bc3ab1d5be7a6c47a7afbf43
ToppCell	facs-GAT-Fat-24m-Lymphocytic\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CISH ETS1 PPP1R16B ITGAL	1.66e-04	183	67	4	377c2c6fcb2fd41396dd7a7a90e9d7ccafccf2f0
ToppCell	facs-Trachea-nan-24m-Lymphocytic\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CISH ETS1 PPP1R16B ITGAL	1.66e-04	183	67	4	568c7e3bde7c6ad2c28ec02c2b073f482c337698
ToppCell	facs-Trachea-nan-24m-Lymphocytic-T_cell\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CISH ETS1 PPP1R16B ITGAL	1.66e-04	183	67	4	2b3ecfc51cdc5333345692747f4fed4c746a769d
ToppCell	facs-GAT-Fat-24m-Lymphocytic-nan\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CISH ETS1 PPP1R16B ITGAL	1.66e-04	183	67	4	f0a6f4f8563491c83fb991b9fb81e75fec7d1ace
ToppCell	facs-Trachea-nan-24m-Lymphocytic-nan\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CISH ETS1 PPP1R16B ITGAL	1.66e-04	183	67	4	79d7aac3b2483ca32430af5ac9f0e578ae064894
ToppCell	facs-SCAT-Fat-18m-Lymphocytic-CD8-positive,_alpha-beta_T_cell\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CISH ETS1 PPP1R16B ITGAL	1.70e-04	184	67	4	f9365feed31e48f3382588bab077f99c5a3f5b04
ToppCell	Smart-seq2-tissue-resident_(Smart-seq2)-myeloid-myeloid_granulocytic-neutrophil\|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	THSD7A GC CXCR1 EPHA5	1.70e-04	184	67	4	7ecdf2645e9378cf2f5ce4557f2cf100e6f184ba
ToppCell	facs-Spleen-nan-3m-Lymphocytic-CD4-positive,_alpha-beta_T_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TXNIP ETS1 ACTN1 PDLIM4	1.70e-04	184	67	4	c37c623c4a5ff1628486d8a6461fa355ad5c264c
ToppCell	facs-SCAT-Fat-18m-Lymphocytic-nan\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CISH ETS1 PPP1R16B ITGAL	1.70e-04	184	67	4	290b8ef0bc4b7b99a2b35b96a756699d3f233b96
ToppCell	facs-SCAT-Fat-18m-Lymphocytic\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CISH ETS1 PPP1R16B ITGAL	1.70e-04	184	67	4	43313b0b4e4d4b18dd67ac0c525d7aa4db493f71
ToppCell	droplet-Lung-21m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l17\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	EPHB2 GLI1 EVC PLEKHA6	1.73e-04	185	67	4	1b990e3089772be2b38c6d7ea0d1bf22461ae3ea
ToppCell	droplet-Thymus-nan-24m-Myeloid-Plasma_cells_and_B_cells\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRRN3 FCGR2B EVC COX4I2	1.73e-04	185	67	4	e583f6601f9ed79b0b23d2f9426a4ba8b969230b
ToppCell	droplet-Thymus-nan-18m-Lymphocytic-nan\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TXNIP CALCOCO1 ETS1 ACTN1	1.73e-04	185	67	4	7acc071ea75442817db4d98bd3ed3fff6f0a9d46
ToppCell	droplet-Spleen-SPLEEN-1m-Lymphocytic-T_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TXNIP ETS1 ACTN1 PDLIM4	1.73e-04	185	67	4	39f2b7a35253968f6d744c10ece1478a05cf24da
ToppCell	facs-Trachea-24m-Hematologic-lymphocytic-T_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CISH ETS1 PPP1R16B ITGAL	1.81e-04	187	67	4	e4a219483118288d414d9017b81927255a5ab8bb
ToppCell	facs-Trachea-24m-Hematologic-lymphocytic-T_cell-T_cell_of_trachea\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CISH ETS1 PPP1R16B ITGAL	1.81e-04	187	67	4	81286565fcd51252c444e490b5f6d401c83b4666
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Degenerative_Proximal_Tubule_Epithelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PPP1R16B EVC PLEKHA6 RREB1	1.81e-04	187	67	4	3ae3b8de1a195d4d5057cf3c64fcdb5f48681ce5
ToppCell	facs-Aorta-Heart-3m-Endothelial-nan\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TXNIP ETS1 PPP1R16B GC	1.81e-04	187	67	4	df0279b7e94e26f5541b0e2a0ce56befa96ec8ca
ToppCell	Control-T_cells\|Control / group, cell type (main and fine annotations)	TXNIP ETS1 PPP1R16B ITGAL	1.81e-04	187	67	4	f4e8e0eba58da89b56587667555a5d4754e108c7
ToppCell	facs-Spleen-nan-3m-Lymphocytic-CD79a_B_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BAZ2B ETS1 PPP1R16B GC	1.81e-04	187	67	4	b51af2824e65734f333b1325117f4a2e88b17c23
ToppCell	droplet-Spleen-SPLEEN-1m\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TXNIP ETS1 ACTN1 PDLIM4	1.84e-04	188	67	4	713fbbd55d2853dee3df2336cada32c153cbd2a1
ToppCell	(1)_T_CD4_naive\|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)	CISH LRRN3 ETS1 ACTN1	1.84e-04	188	67	4	b8f67ac2faadd5b848955e43ab5d6cf5e49b3681
ToppCell	BAL-Severe-Myeloid-cDC-cDC-cDC_0\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CISH TBXAS1 AOC1 FCGR2B	1.84e-04	188	67	4	9fc3819aae5a2b2534cb131d467435b5cfc420d6
ToppCell	BAL-Severe-Myeloid-cDC-cDC-cDC_0\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	CISH TBXAS1 AOC1 FCGR2B	1.84e-04	188	67	4	5e5d779ea079d3b2a1ef650b06b9f5cc1ffef5e7
ToppCell	kidney_cells-Hypertensive_with+without-CKD\|kidney_cells / Celltypes from Cells and Nuclei per compartment and clinical group	TXNIP AOC1 THSD7A TMBIM4	1.84e-04	188	67	4	90188b60ff893754f7938fe8edab79758827168e
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	EPHB2 ACTN4 PLEKHG2 PDLIM4	1.88e-04	189	67	4	8c8ca3b30d9be6c854615459a7bfba82b427c8bc
ToppCell	E16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-PMP-PMP_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ANKFY1 GLI1 ACTN1 EPHA5	1.88e-04	189	67	4	3169476f98b7385706cb618c9ad64ae83a290ef0
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	EPHB2 ACTN4 PLEKHG2 PDLIM4	1.88e-04	189	67	4	5d902a4660a27548764bf04c6de152b565da835c
ToppCell	367C-Lymphocytic-NK_cells-NK_cell_B1\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	TRAF7 ANKFY1 CPSF6 HPS3	1.92e-04	190	67	4	2434b8ad2976eab7d9147012c28454ab29670709
ToppCell	droplet-Spleen-SPLEEN-1m-Lymphocytic-nan\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TXNIP ETS1 ACTN1 PDLIM4	1.92e-04	190	67	4	55be54c39ac9eb8e2c1515d8c212130ce2b0ef88
ToppCell	Control-T_cells-CD4+_T_cells\|Control / group, cell type (main and fine annotations)	TXNIP ETS1 PPP1R16B ITGAL	1.92e-04	190	67	4	0733be5e54fe15d6d6ea51c154a95258e83f1b92
ToppCell	droplet-Spleen-SPLEEN-1m-Lymphocytic\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TXNIP ETS1 ACTN1 PDLIM4	1.92e-04	190	67	4	24b78a6f2a763acb8f4e90a5d245c9c77605b426
ToppCell	droplet-Limb_Muscle-Pre-Sort-18m-Mesenchymal-smooth_muscle_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IRS4 ACTN1 COX4I2 ITPK1	1.96e-04	191	67	4	8e8beb8e8a3b33cac83d3f7ce915a71e3654fdab
ToppCell	droplet-Limb_Muscle-Pre-Sort-18m-Mesenchymal-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IRS4 ACTN1 COX4I2 ITPK1	1.96e-04	191	67	4	60bc1f3efa7bbad5cb7944fe5e049ea79cd1745a
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c01-LEF1\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	TXNIP LRRN3 ETS1 ACTN1	1.96e-04	191	67	4	fda432a7f79664e8ffd5d03c1c69ec43bbac994b
ToppCell	ASK452-Immune-NK_cell\|Immune / Donor, Lineage and Cell class of Lung cells from Dropseq	TXNIP ETS1 GSDMB ITGAL	2.00e-04	192	67	4	f04ee5aaa54c39b7493098fb3d2f78168d6b8060
ToppCell	droplet-Thymus-nan-18m\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TXNIP ETS1 ACTN1 PCBP2	2.04e-04	193	67	4	81871f4f2b63ca5f64a9ff12f6c909a34bf52216
ToppCell	PBMC-Severe-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CISH TXNIP LRRN3 ETS1	2.04e-04	193	67	4	2901d7a9672a8cf70c9f1c752685b45e4d79ac70
ToppCell	CD8+_Memory_T_cell-CV-0\|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster	TXNIP CCNDBP1 CALCOCO1 ING4	2.04e-04	193	67	4	995781d87a919c0380750878bafe584342bb83ad
ToppCell	COVID-19_Severe-Lymphoid_T/NK-CD4+_T_activated\|COVID-19_Severe / Disease group, lineage and cell class	CISH TXNIP LRRN3 ETS1	2.04e-04	193	67	4	beb862d38b88572836b0a797c8efef7a2492e0b9
ToppCell	PBMC-Severe-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CISH TXNIP LRRN3 ETS1	2.04e-04	193	67	4	f4310faa13fc8ce99a217e2d1c9cc733683797a1
ToppCell	10x_3'_v2v3-Non-neoplastic-Lymphoid-CD4/CD8-CD8_NK_sig-F\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	TXNIP ETS1 ANKRD24 ITGAL	2.04e-04	193	67	4	db9378c5bb5c27b321957a05dcabf40e97a3b725
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c04-COTL1\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	PPP3CA ETS1 ACTN4 ITGAL	2.04e-04	193	67	4	778fcf8448e81fe18972d97ea8a30ab036d16fe5
ToppCell	PBMC-Severe-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	CISH TXNIP LRRN3 ETS1	2.04e-04	193	67	4	f8af695457d2a0a911a5ac491742465864ebda37
ToppCell	PBMC-Severe-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	CISH TXNIP LRRN3 ETS1	2.04e-04	193	67	4	089aece40130034a89a5213be778f10b0787eeba
ToppCell	metastatic_Lymph_Node-T/NK_cells-Cytotoxic_CD8+_T\|metastatic_Lymph_Node / Location, Cell class and cell subclass	TXNIP ETS1 PTCH1 ITGAL	2.08e-04	194	67	4	73c057b623829de793616d9d373a0018071d51d8
ToppCell	LPS-IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	THSD7A BAZ2B ETS1 PPP1R16B	2.08e-04	194	67	4	0b9cd96fa0b616da7cc90e92ff71157e9bba518f
ToppCell	mild-Myeloid-Neutrophils_1\|mild / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	TBXAS1 BAZ2B ACTN1 CXCR1	2.08e-04	194	67	4	ccd911ce3251cd1c60f1fb2ce00650fbe7a379bb
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Immune\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	TBXAS1 ETS1 PPP1R16B ITGAL	2.08e-04	194	67	4	4dfc890bacf133cfb6ec7c8b73f084f2491cf78e
ToppCell	CV-Moderate-0\|CV / Virus stimulation, Condition and Cluster	TXNIP CCNDBP1 CALCOCO1 ING4	2.08e-04	194	67	4	9ff69139dae007fcc349daefcb5021defb0e0d2a
ToppCell	facs-Aorta-Heart-3m-Endothelial\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TXNIP ETS1 PPP1R16B ACTN4	2.12e-04	195	67	4	8493f2f60fc356af28b9c0e287d4cd8c8899c081
ToppCell	COVID-19_Moderate-CD4+_T_naive\|World / disease group, cell group and cell class	CISH TXNIP LRRN3 ETS1	2.12e-04	195	67	4	38d65cf0895f7a99d789ec3dcbd56a7506706d38
Drug	Promazine hydrochloride [53-60-1]; Down 200; 12.4uM; PC3; HT_HG-U133A	EPHB2 TXNIP VPS41 ING4 ENTPD4 PDLIM4	2.30e-05	194	67	6	4308_DN
Drug	Dimethadione [695-53-4]; Down 200; 31uM; PC3; HT_HG-U133A	CISH ZNF16 FARSA ANKFY1 ING4 EPHA5	2.36e-05	195	67	6	4607_DN
Drug	Flecainide acetate [54143-56-5]; Up 200; 8.4uM; MCF7; HT_HG-U133A	EPHB2 ANKFY1 GUCY2D GSDMB ING4 ACTN1	2.36e-05	195	67	6	3843_UP
Drug	Isocarboxazid [59-63-2]; Down 200; 17.2uM; PC3; HT_HG-U133A	EPHB2 PLEKHM2 VPS41 GSDMB ENTPD4 KYAT1	2.50e-05	197	67	6	7383_DN
Drug	troglitazone; Up 200; 10uM; MCF7; HT_HG-U133A	EPHB2 SCN11A AOC1 ING4 ACTN1 ITGAL	2.57e-05	198	67	6	5592_UP
Drug	CGX 0596987; Up 200; 20uM; PC3; HT_HG-U133A	LRRN3 GUCY2D VPS41 PTCH1 ITPK1 PDLIM4	2.57e-05	198	67	6	6369_UP
Drug	methylmercury II	CISH TXNIP GC ACTN1 ITGAL	2.78e-05	120	67	5	ctd:C030957
Drug	2-nitrotoluene	CISH ACTN4 ACTN1 WNT4	3.15e-05	61	67	4	ctd:C029955
Disease	alkaline phosphatase measurement	TRAF7 MAP2K4 AOC1 BAIAP2L1 FCGR2B GSDMB EVC WNT4 RREB1 PTCH1 CLUH TULP2	2.70e-06	1015	67	12	EFO_0004533
Disease	spina bifida (is_marker_for)	GLI1 PTCH1	5.08e-06	2	67	2	DOID:0080016 (is_marker_for)
Disease	squamous cell carcinoma (implicated_via_orthology)	ING5 ING4	1.52e-05	3	67	2	DOID:1749 (implicated_via_orthology)
Disease	nevoid basal cell carcinoma syndrome (is_marker_for)	GLI1 PTCH1	1.52e-05	3	67	2	DOID:2512 (is_marker_for)
Disease	Ellis-Van Creveld Syndrome	GLI1 EVC	3.04e-05	4	67	2	C0013903
Disease	focal segmental glomerulosclerosis 1 (implicated_via_orthology)	ACTN4 ACTN1	5.06e-05	5	67	2	DOID:0111128 (implicated_via_orthology)
Disease	melanoma (implicated_via_orthology)	ING5 ING4	1.41e-04	8	67	2	DOID:1909 (implicated_via_orthology)
Disease	neutrophil count, basophil count	FCGR2B ETS1 GC RREB1 CXCR1	1.59e-04	224	67	5	EFO_0004833, EFO_0005090
Disease	hepatocellular carcinoma (implicated_via_orthology)	TXNIP ING5 ING4	1.91e-04	49	67	3	DOID:684 (implicated_via_orthology)
Disease	–	CISH FCGR2B	5.97e-04	16	67	2	611162
Disease	Malaria, susceptibility to	CISH FCGR2B	5.97e-04	16	67	2	cv:C1970028
Disease	Malaria	CISH FCGR2B	9.40e-04	20	67	2	C0024530
Disease	carpal tunnel syndrome	AOC1 CPSF6 WNT4	1.11e-03	89	67	3	EFO_0004143
Disease	myeloid white cell count	TBXAS1 BAIAP2L1 FCGR2B ETS1 GC RREB1 ITGAL CXCR1	1.25e-03	937	67	8	EFO_0007988
Disease	malaria (is_implicated_in)	CISH FCGR2B	1.36e-03	24	67	2	DOID:12365 (is_implicated_in)
Disease	neutrophil count, eosinophil count	FCGR2B ETS1 GC CXCR1	1.42e-03	213	67	4	EFO_0004833, EFO_0004842
Disease	lymphocyte count	AOC1 BAIAP2L1 ANAPC1 ETS1 GSDMB GC PLEKHA6 RREB1 ITPK1 PDLIM4	1.65e-03	1464	67	10	EFO_0004587
Disease	Carcinoma, Ovarian Epithelial	PPP3CA WNT4	2.12e-03	30	67	2	C4721610
Disease	NEPHROTIC SYNDROME, STEROID-RESISTANT, AUTOSOMAL RECESSIVE	ANKFY1 ACTN4	2.12e-03	30	67	2	C1868672
Disease	birth weight	FCGR2B BAZ2B WNT4 RREB1 PTCH1	2.14e-03	399	67	5	EFO_0004344

Protein segments in the cluster

Peptide	Gene	Start	Entry
ELPPDQAEYCIARMA	ACTN1	851	P12814
MCPEPASEREDLVYF	BAZ2B	1821	Q9UIF8
VEEGYRLPSPMDCPA	EPHA5	891	P54756
SPPDMDYDPEARILC	GSDMB	381	Q8TAX9
PGYPECREMGETLPE	FCGR2B	256	P31994
LPPDQAEYCIARMAP	ACTN4	871	O43707
MDLDSPSPCLYEPLL	ARMC5	726	Q96C12
ADVDCLPLPRRMADY	CISH	236	Q9NSE2
PEDRDCSMPPPFSYN	AOC1	731	P19801
PASIPMPDDRDAYEE	ANKRD24	311	Q8TF21
CRPYMAPERIDPSAS	MAP2K4	266	P45985
EIGRPPGPEMEYCTD	ANAPC1	1276	Q9H1A4
DLFLECMPGYPLDKP	ANKFY1	1026	Q9P2R3
DIAEPHIPCLMPEYF	PTCD3	131	Q96EY7
IEAYMEDDRICSPPF	ITPK1	116	Q13572
MADPDPRYPRSSIED	TMBIM4	1	Q9HC24
ELDMETNIFCPPPLY	MAP10	291	Q9P2G4
CRSAPYAMLELTPEE	GUCY2D	741	Q02846
QDYRLPPPMDCPSAL	EPHB2	841	P29323
LELFPSPDMECADVP	ETS1	21	P14921
DYLPSEPRPCLDFDS	GLI1	871	P08151
DAPYPMLILAGPEAC	LRGUK	411	Q96M69
MCLNPDLEGPPLEAY	PCBP2	216	Q15366
DGNMPYDLCEDEPTL	PPP1R16B	166	Q96T49
EPMLAIDCREPYAFD	BTBD18	456	B2RXH4
MEAPSPPLRALYESC	ESPL1	326	Q14674
PPDYLECLSMGAAAD	BAIAP2L1	436	Q9UHR4
APEDRDYMDTLPPTV	CPSF6	46	Q16630
PSVDDLALSIYPPMC	CCNDBP1	286	O95273
YFPMASDIDPPDLDL	FAM83C	116	Q9BQN1
CDPPSDRDSYVRELM	FUT10	221	Q6P4F1
PPADEDYSPCMLETE	CXCR1	21	P25024
VLDMPVDPNEPTYCL	ING5	176	Q8WYH8
MTGLPPEECDYLRQE	EVC	546	P57679
DESPEDMRLPPYGLC	CALCOCO1	541	Q9P1Z2
DRFKEPPAYGPMCDI	PPP3CA	216	Q08209
YPMPEEPFCTELNAE	COX4I2	46	Q96KJ9
VLDMPVDPNEPTYCL	ING4	186	Q9UNL4
LVKMADEAYCPPRFP	OTOF	1056	Q9HC10
CREPPYPSILTDATM	PLEKHM2	706	Q8IWE5
AFDEDEDDPYVPMRP	IRS4	691	O14654
MVYDSPLCRLDAEPR	FARSA	486	Q9Y285
VEDYLCDPEEMPLGS	THSD7A	1141	Q9UPZ6
EDPYMDTTLKACPPV	HPS3	406	Q969F9
IRFMEPDSLFCVDPP	LRRN3	386	Q9H3W5
MPDLPGAVDEPYDRR	KYAT1	351	Q16773
DMPYLDPCLPLDIKD	ENTPD4	361	Q9Y227
YRMLREPAEPVAAEP	PDLIM4	191	P50479
YMDRPCLNPADPDCP	PTCH1	291	Q13635
PPCVVPSRAYEMDET	STARD9	2996	Q9P2P6
DEIMLLYPSEAGCPV	STARD9	3616	Q9P2P6
QMEPPVPCHYEDLER	ITGAL	991	P20701
GLEMDPIDCTPPEYI	CLUH	176	O75153
PESICSMPAYDRISP	PLEKHA6	371	Q9Y2H5
PEFCSLEEGLPYLDM	TBXAS1	381	P24557
IRSPCPGLEEDMEAY	TULP2	261	O00295
RSSPPMLSADDAEYP	SRCIN1	11	Q9C0H9
VPYDCSMEPIDLSIP	RREB1	926	Q92766
CTYFMPAAQLPELPD	GC	311	P02774
LAYSPRDEEDSMPPI	TRAF7	66	Q6Q0C0
VPRDDISLRPDMYPC	VPS41	206	P49754
DPLPYDIIVDPMCGT	THUMPD3	316	Q9BV44
DSIMCQKVPPEERPY	ZNF397	271	Q8NF99
CQEIPTEERPHPYDM	ZNF16	171	P17020
VYLEPSPDFCEQDMR	WNT4	271	P56705
MDDRCYPVIFPDERN	SCN11A	1	Q9UI33
DISDVFEMPCLPAIP	PLEKHG2	661	Q9H7P9
PPCYMDVIPEDHRLE	TXNIP	331	Q9H3M7