Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	spermatogenesis	CYLC1 SPATA31A1 SPATA31A3 SPATA31A7 CHD5 SPATA31C2 SPATA31A6 SPATA31C1 SPATA31A5 TAFAZZIN SMAD4	5.26e-07	744	46	11	GO:0007283
GeneOntologyBiologicalProcess	male gamete generation	CYLC1 SPATA31A1 SPATA31A3 SPATA31A7 CHD5 SPATA31C2 SPATA31A6 SPATA31C1 SPATA31A5 TAFAZZIN SMAD4	6.66e-07	762	46	11	GO:0048232
GeneOntologyBiologicalProcess	gamete generation	CYLC1 SPATA31A1 SPATA31A3 SPATA31A7 CHD5 SPATA31C2 NDN SPATA31A6 SPATA31C1 SPATA31A5 TAFAZZIN SMAD4	1.10e-06	982	46	12	GO:0007276
GeneOntologyBiologicalProcess	multicellular organismal reproductive process	CYLC1 SPATA31A1 SPATA31A3 SPATA31A7 CHD5 SPATA31C2 NDN SPATA31A6 SPATA31C1 SPATA31A5 TAFAZZIN SMAD4	8.31e-06	1194	46	12	GO:0048609
GeneOntologyBiologicalProcess	developmental process involved in reproduction	CYLC1 SPATA31A1 SPATA31A3 SPATA31A7 CHD5 SPATA31C2 NDN SPATA31A6 SPATA31C1 SPATA31A5 TAFAZZIN SMAD4	1.17e-05	1235	46	12	GO:0003006
GeneOntologyBiologicalProcess	sexual reproduction	CYLC1 SPATA31A1 SPATA31A3 SPATA31A7 CHD5 SPATA31C2 NDN SPATA31A6 SPATA31C1 SPATA31A5 TAFAZZIN SMAD4	2.15e-05	1312	46	12	GO:0019953
GeneOntologyCellularComponent	acrosomal vesicle	CYLC1 SPATA31A1 SPATA31A3 SPATA31A7 SPATA31A6 SPATA31C1 SPATA31A5	3.15e-07	206	46	7	GO:0001669
GeneOntologyCellularComponent	NuRD complex	CHD5 CHD3	6.31e-04	17	46	2	GO:0016581
GeneOntologyCellularComponent	CHD-type complex	CHD5 CHD3	6.31e-04	17	46	2	GO:0090545
Domain	DUF4599	SPATA31A3 SPATA31A7 SPATA31C2 SPATA31A6 SPATA31C1 SPATA31A5	1.45e-13	12	46	6	PF15371
Domain	DUF4599	SPATA31A3 SPATA31A7 SPATA31C2 SPATA31A6 SPATA31C1 SPATA31A5	1.45e-13	12	46	6	IPR027970
Domain	DUF4062	NWD2 TEP1	5.93e-06	2	46	2	PF13271
Domain	DUF4062	NWD2 TEP1	5.93e-06	2	46	2	IPR025139
Domain	-	ABCA2 NWD2 MPP4 RHOBTB2 CHD5 HELZ GIMAP1 CHD3 LRRK1 TEP1	1.08e-05	746	46	10	3.40.50.300
Domain	CHDCT2	CHD5 CHD3	1.78e-05	3	46	2	PF08074
Domain	CHDNT	CHD5 CHD3	1.78e-05	3	46	2	PF08073
Domain	DUF1086	CHD5 CHD3	1.78e-05	3	46	2	IPR009462
Domain	DUF1087	CHD5 CHD3	1.78e-05	3	46	2	IPR009463
Domain	DUF1087	CHD5 CHD3	1.78e-05	3	46	2	PF06465
Domain	DUF1086	CHD5 CHD3	1.78e-05	3	46	2	PF06461
Domain	DUF1087	CHD5 CHD3	1.78e-05	3	46	2	SM01147
Domain	DUF1086	CHD5 CHD3	1.78e-05	3	46	2	SM01146
Domain	CHD_N	CHD5 CHD3	1.78e-05	3	46	2	IPR012958
Domain	CHD_C2	CHD5 CHD3	1.78e-05	3	46	2	IPR012957
Domain	P-loop_NTPase	ABCA2 NWD2 MPP4 RHOBTB2 CHD5 HELZ GIMAP1 CHD3 LRRK1 TEP1	3.25e-05	848	46	10	IPR027417
Domain	TM_Fragile-X-F-assoc	TMEM185B TMEM185A	3.55e-05	4	46	2	IPR019396
Domain	Tmemb_185A	TMEM185B TMEM185A	3.55e-05	4	46	2	PF10269
Domain	Zinc_finger_PHD-type_CS	CHD5 BRPF1 CHD3	5.49e-04	65	46	3	IPR019786
Domain	Znf_PHD-finger	CHD5 BRPF1 CHD3	9.70e-04	79	46	3	IPR019787
Domain	Quino_amine_DH_bsu	LRRK1 TEP1	1.33e-03	22	46	2	IPR011044
Domain	PHD	CHD5 BRPF1 CHD3	1.37e-03	89	46	3	SM00249
Domain	Znf_PHD	CHD5 BRPF1 CHD3	1.46e-03	91	46	3	IPR001965
Domain	Chromo_domain	CHD5 CHD3	1.58e-03	24	46	2	IPR023780
Domain	ZF_PHD_2	CHD5 BRPF1 CHD3	1.65e-03	95	46	3	PS50016
Domain	ZF_PHD_1	CHD5 BRPF1 CHD3	1.70e-03	96	46	3	PS01359
Domain	Chromo	CHD5 CHD3	1.86e-03	26	46	2	PF00385
Domain	CHROMO_2	CHD5 CHD3	2.15e-03	28	46	2	PS50013
Domain	CHROMO_1	CHD5 CHD3	2.15e-03	28	46	2	PS00598
Domain	SNF2_N	CHD5 CHD3	2.81e-03	32	46	2	PF00176
Domain	SNF2_N	CHD5 CHD3	2.81e-03	32	46	2	IPR000330
Domain	Chromodomain-like	CHD5 CHD3	2.81e-03	32	46	2	IPR016197
Domain	CHROMO	CHD5 CHD3	2.98e-03	33	46	2	SM00298
Domain	Chromo/shadow_dom	CHD5 CHD3	2.98e-03	33	46	2	IPR000953
Domain	DNA/RNA_helicase_DEAH_CS	CHD5 CHD3	3.35e-03	35	46	2	IPR002464
Domain	DEAH_ATP_HELICASE	CHD5 CHD3	3.94e-03	38	46	2	PS00690
Domain	Znf_FYVE_PHD	CHD5 BRPF1 CHD3	5.66e-03	147	46	3	IPR011011
Domain	WD40_repeat_dom	NWD2 LRRK1 TEP1 WDFY4	6.05e-03	297	46	4	IPR017986
Domain	WD40_repeat_CS	NWD2 TEP1 WDFY4	7.65e-03	164	46	3	IPR019775
Domain	-	CHD5 CHD3	8.11e-03	55	46	2	1.10.30.10
Domain	HMG_box_dom	CHD5 CHD3	1.12e-02	65	46	2	IPR009071
Pubmed	The testis-specific VAD1.3/AEP1 interacts with β-actin and syntaxin 1 and directs peri-nuclear/Golgi expression with bipartite nucleus localization (BNL) sequence.	SPATA31A1 SPATA31A3 SPATA31A7 SPATA31A6 SPATA31C1 SPATA31A5	5.69e-18	6	49	6	20850414
Pubmed	Targeted disruption of the spermatid-specific gene Spata31 causes male infertility.	SPATA31A1 SPATA31A3 SPATA31A7 SPATA31A6 SPATA31C1 SPATA31A5	5.69e-18	6	49	6	25930072
Pubmed	Majority of cerebrospinal fluid-contacting neurons in the spinal cord of C57Bl/6N mice is present in ectopic position unlike in other studied experimental mice strains and mammalian species.	SPATA31A1 SPATA31A3 SPATA31A7 SPATA31A6 SPATA31C1 SPATA31A5	7.52e-13	24	49	6	32212159
Pubmed	A novel gene, FAM11A, associated with the FRAXF CpG island is transcriptionally silent in FRAXF full mutation.	TMEM185B TMEM185A	1.94e-06	2	49	2	12404111
Pubmed	Cloning of a novel neuronally expressed orphan G-protein-coupled receptor which is up-regulated by erythropoietin, interacts with microtubule-associated protein 1b and colocalizes with the 5-hydroxytryptamine 2a receptor.	TMEM185B TMEM185A	1.94e-05	5	49	2	15525354
Pubmed	Molecular genetics of the human MHC complement gene cluster.	DXO CYP21A2	5.42e-05	8	49	2	10072631
Pubmed	Organizations and gene duplications of the human and mouse MHC complement gene clusters.	DXO CYP21A2	1.06e-04	11	49	2	10686478
Pubmed	Role of heat-shock factor 2 in cerebral cortex formation and as a regulator of p35 expression.	RELN NDN	1.27e-04	12	49	2	16600913
Pubmed	DLX1 and the NuRD complex cooperate in enhancer decommissioning and transcriptional repression.	CHD5 CHD3	2.02e-04	15	49	2	35695185
Pubmed	A Functional Switch of NuRD Chromatin Remodeling Complex Subunits Regulates Mouse Cortical Development.	CHD5 CHD3	2.61e-04	17	49	2	27806305
Pubmed	Smad4 and Trim33/Tif1γ redundantly regulate neural stem cells in the developing cortex.	RELN SMAD4	2.93e-04	18	49	2	23765158
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	ABCA2 CHD5 JOSD1 LRRK1 TEP1 ABTB2 CYTH4	8.59e-04	1105	49	7	35748872
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	ABCA2 CHD5 JOSD1 LRRK1 IGSF1	8.78e-04	529	49	5	14621295
Pubmed	Identification of the BRD1 interaction network and its impact on mental disorder risk.	CHD5 CHD3	1.12e-03	35	49	2	27142060
Pubmed	A SMAD1/5-YAP signalling module drives radial glia self-amplification and growth of the developing cerebral cortex.	RELN NDN	1.32e-03	38	49	2	32541003
Pubmed	Cross-linking mass spectrometry reveals the structural topology of peripheral NuRD subunits relative to the core complex.	CHD5 CHD3	1.32e-03	38	49	2	33283408
Cytoband	Ensembl 112 genes in cytogenetic band chr9q12	SPATA31A7 SPATA31A5	3.11e-05	8	49	2	chr9q12
Cytoband	9p13.1	SPATA31A1 SPATA31A3	3.03e-04	24	49	2	9p13.1
GeneFamily	PHD finger proteins\|NuRD complex	CHD5 CHD3	1.20e-04	12	25	2	1305
GeneFamily	PHD finger proteins	CHD5 BRPF1 CHD3	2.53e-04	90	25	3	88
GeneFamily	Basic leucine zipper proteins\|BTB domain containing	RHOBTB2 ABTB2	1.46e-02	134	25	2	861
Disease	renal overload-type gout	SPATA31C2 SPATA31C1	3.25e-05	6	44	2	EFO_0021525
Disease	X-16570 measurement	FA2H CYP21A2	3.25e-05	6	44	2	EFO_0800759
Disease	N-palmitoylglycine measurement	FA2H CYP21A2	4.54e-05	7	44	2	EFO_0800342
Disease	eosinophil cationic protein measurement	SPATA31C2 SPATA31C1	6.05e-05	8	44	2	EFO_0010913
Disease	longitudinal alcohol consumption measurement	SPATA31C2 SPATA31C1	7.77e-05	9	44	2	EFO_0007645
Disease	egg allergy measurement, parental genotype effect measurement	SPATA31C2 SPATA31C1	1.68e-04	13	44	2	EFO_0005939, EFO_0007018
Disease	amygdala volume change measurement	SPATA31C2 SPATA31C1	2.57e-04	16	44	2	EFO_0021490
Disease	intrahepatic cholangiocarcinoma (is_marker_for)	TEP1 SMAD4	3.66e-04	19	44	2	DOID:4928 (is_marker_for)
Disease	empathy measurement	ECEL1 IGSF1 UNC79	2.09e-03	170	44	3	EFO_0009183
Disease	body weight	RELN CYP21A2 SPATA31C2 POM121L2 NDN SPATA31C1 UNC79	2.45e-03	1261	44	7	EFO_0004338
Disease	complement C4 measurement	DXO CYP21A2	2.75e-03	52	44	2	EFO_0004984

Protein segments in the cluster

Peptide	Gene	Start	Entry
TPELHRWLRIKLWIS	ARSH	156	Q5FYA8
KGKVQRILHWRWTEP	CHD5	466	Q8TDI0
IRQKWILPAHKWKPL	ALLC	306	Q8N6M5
LLKLGGRVKTWKRRW	CYTH4	266	Q9UIA0
WLKIIWRRHGIWPLE	C22orf42	86	Q6IC83
RKLWWLPAHLPRFVR	NWD2	526	Q9ULI1
YVKLRWLLKHWRQGK	MTCL1	1041	Q9Y4B5
LIPKLKGWWQKFRLR	ANO7	661	Q6IWH7
PALVSPRRVRVKWWK	HAPLN3	76	Q96S86
LRVKWSHLRLPWVDL	LRRK1	256	Q38SD2
RLLWNWWKLRSLHLP	CYP21A2	16	P08686
FEHRIPKEQWWLKLR	PFKP	741	Q01813
WIRHSFRKILQWPPI	CYLC1	76	P35663
HLLKRKQREFWWSQP	MPP4	306	Q96JB8
LCWGPLKLPLKRQHW	JOSD1	126	Q15040
VEELRRKWPVAWGKL	HELZ	931	P42694
RHKLLKWWAQSFLPG	DXO	271	O77932
QLQKITPHLRWKWLL	ECEL1	346	O95672
ARMKGVLLRWWQPRH	RELN	3396	P78509
WRKPLLWQVGHLGEK	FA2H	126	Q7L5A8
KWLKSPRSWRLGLAL	GIMAP1	266	Q8WWP7
GVVLAIEWKKWPRLR	IGSF1	1276	Q8N6C5
LRFIQLKNPWSHLRW	CAPN7	471	Q9Y6W3
KGRVQKILHWRWGEP	CHD3	506	Q12873
LWKNVTLKRRSPWVL	ABCA2	11	Q9BZC7
KWSHKNSPIIWRELL	MDH1B	56	Q5I0G3
LKINNSKHRWFWLLP	HEATR1	151	Q9H583
ELIWKNREPLVKIWH	PARL	351	Q9H300
VRFWAKHRWGLPLRV	SPATA31C2	651	B4DYI2
IALRLDKIIHWPWLV	TMEM185A	156	Q8NFB2
IALKLDRIIHWPWLV	TMEM185B	156	Q9H7F4
VRFWAKHRWGLPLRV	SPATA31A6	801	Q5VVP1
RFWAKHRWGLPLRVL	SPATA31A7	806	Q8IWB4
ARLWRWPDLHKNELK	SMAD4	96	Q13485
LHLKRQPKRRWLFWN	RHOBTB2	691	Q9BYZ6
IVRFWAKHRWGLPLR	SPATA31C1	656	P0DKV0
LKRTIWSLRHPRPIW	POM121L2	101	Q96KW2
LRALGVPWKLHIWIE	ABTB2	736	Q8N961
KRTWQWLPRTKLVPL	BRPF1	1151	P55201
RFWAKHRWGLPLRVL	SPATA31A3	806	Q5VYP0
RRWHLQHTLRWLNKP	TEP1	1646	Q99973
RFWAKHRWGLPLRVL	SPATA31A1	806	Q5TZJ5
PHLWGILKLRHIWNL	TAFAZZIN	76	Q16635
ILKLRHIWNLKLMRW	TAFAZZIN	81	Q16635
RFWAKHRWGLPLRVL	SPATA31A5	806	Q5VU36
PRVWKQKSSLIWRLG	WDFY4	1221	Q6ZS81
RKLWSHIRRPWGIAV	SLC10A6	56	Q3KNW5
LSTGIPKEWRRKVWL	TBC1D30	246	Q9Y2I9
PWKKRTLNQVHRVPW	nan	241	Q3C1V9
SLWSLKPHIRQMWLK	UNC79	1386	Q9P2D8
WNVLRILGLRPWKKH	NDN	211	Q99608