Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	BH domain binding	BAK1 PXN BAX	9.17e-06	14	60	3	GO:0051400
GeneOntologyMolecularFunction	high voltage-gated calcium channel activity	CACNB1 CACNB2 CACNA1I	9.17e-06	14	60	3	GO:0008331
GeneOntologyMolecularFunction	voltage-gated calcium channel activity	CACNB1 CACNB2 CACNG8 CACNA1I	1.09e-05	46	60	4	GO:0005245
GeneOntologyMolecularFunction	scavenger receptor activity	MSR1 SSC5D CD163	7.17e-05	27	60	3	GO:0005044
GeneOntologyMolecularFunction	cargo receptor activity	MSR1 SSC5D LSR CD163	1.24e-04	85	60	4	GO:0038024
GeneOntologyMolecularFunction	laminin binding	TINAGL1 SSC5D FKRP	1.44e-04	34	60	3	GO:0043236
GeneOntologyMolecularFunction	aminoacyltransferase activity	AREL1 MIB1 BIRC2 BIRC3 HERC2 TGM6 FBXO27 BIRC6	1.82e-04	532	60	8	GO:0016755
GeneOntologyMolecularFunction	ubiquitin-protein transferase activity	AREL1 MIB1 BIRC2 BIRC3 HERC2 FBXO27 BIRC6	5.23e-04	473	60	7	GO:0004842
GeneOntologyMolecularFunction	calcium channel regulator activity	CACNB2 CACNG8 REM2	5.74e-04	54	60	3	GO:0005246
GeneOntologyMolecularFunction	calcium channel activity	CACNB1 CACNB2 CACNG8 CACNA1I	6.13e-04	129	60	4	GO:0005262
GeneOntologyMolecularFunction	ubiquitin-like protein transferase activity	AREL1 MIB1 BIRC2 BIRC3 HERC2 FBXO27 BIRC6	8.34e-04	512	60	7	GO:0019787
GeneOntologyMolecularFunction	ubiquitin protein ligase activity	AREL1 MIB1 BIRC2 BIRC3 HERC2 FBXO27	8.61e-04	372	60	6	GO:0061630
GeneOntologyMolecularFunction	calcium ion transmembrane transporter activity	CACNB1 CACNB2 CACNG8 CACNA1I	1.10e-03	151	60	4	GO:0015085
GeneOntologyMolecularFunction	voltage-gated monoatomic cation channel activity	CACNB1 CACNB2 CACNG8 CACNA1I	1.13e-03	152	60	4	GO:0022843
GeneOntologyMolecularFunction	ubiquitin-like protein ligase activity	AREL1 MIB1 BIRC2 BIRC3 HERC2 FBXO27	1.22e-03	398	60	6	GO:0061659
GeneOntologyMolecularFunction	low-density lipoprotein particle binding	MSR1 LSR	1.32e-03	18	60	2	GO:0030169
GeneOntologyMolecularFunction	extracellular matrix binding	TINAGL1 SSC5D FKRP	1.38e-03	73	60	3	GO:0050840
GeneOntologyMolecularFunction	protein-folding chaperone binding	BAK1 BAX BIRC2 TG	1.40e-03	161	60	4	GO:0051087
GeneOntologyMolecularFunction	acyltransferase activity	AREL1 MIB1 BIRC2 BIRC3 HERC2 TGM6 FBXO27 BIRC6	2.13e-03	775	60	8	GO:0016746
GeneOntologyMolecularFunction	semaphorin receptor binding	SEMA3B PLXNB1	2.16e-03	23	60	2	GO:0030215
GeneOntologyMolecularFunction	voltage-gated monoatomic ion channel activity	CACNB1 CACNB2 CACNG8 CACNA1I	2.19e-03	182	60	4	GO:0005244
GeneOntologyMolecularFunction	voltage-gated channel activity	CACNB1 CACNB2 CACNG8 CACNA1I	2.28e-03	184	60	4	GO:0022832
GeneOntologyMolecularFunction	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	BIRC2 BIRC3	2.35e-03	24	60	2	GO:0043027
GeneOntologyMolecularFunction	cytoskeletal anchor activity	SPTBN4 INSC	2.35e-03	24	60	2	GO:0008093
GeneOntologyMolecularFunction	channel activity	CACNB1 CACNB2 CACNG8 BAK1 BAX CACNA1I	4.84e-03	525	60	6	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	CACNB1 CACNB2 CACNG8 BAK1 BAX CACNA1I	4.88e-03	526	60	6	GO:0022803
GeneOntologyMolecularFunction	lipoprotein particle binding	MSR1 LSR	4.96e-03	35	60	2	GO:0071813
GeneOntologyMolecularFunction	protein-lipid complex binding	MSR1 LSR	4.96e-03	35	60	2	GO:0071814
GeneOntologyMolecularFunction	fibronectin binding	SSC5D LOXL3	5.82e-03	38	60	2	GO:0001968
GeneOntologyMolecularFunction	frizzled binding	WNT5B WNT9A	7.08e-03	42	60	2	GO:0005109
GeneOntologyBiologicalProcess	B cell negative selection	BAK1 BAX	7.50e-06	2	57	2	GO:0002352
GeneOntologyBiologicalProcess	B cell selection	BAK1 BAX	1.12e-04	6	57	2	GO:0002339
GeneOntologyBiologicalProcess	post-embryonic camera-type eye morphogenesis	BAK1 BAX	1.12e-04	6	57	2	GO:0048597
GeneOntologyBiologicalProcess	apoptotic process involved in blood vessel morphogenesis	BAK1 BAX	1.12e-04	6	57	2	GO:1902262
GeneOntologyBiologicalProcess	post-embryonic eye morphogenesis	BAK1 BAX	1.56e-04	7	57	2	GO:0048050
GeneOntologyBiologicalProcess	positive regulation of IRE1-mediated unfolded protein response	BAK1 BAX	2.08e-04	8	57	2	GO:1903896
GeneOntologyBiologicalProcess	negative regulation of endoplasmic reticulum calcium ion concentration	BAK1 BAX	2.08e-04	8	57	2	GO:0032471
GeneOntologyBiologicalProcess	calcium ion transport into cytosol	BAK1 BAX CACNA1I	2.13e-04	42	57	3	GO:0060402
GeneOntologyCellularComponent	L-type voltage-gated calcium channel complex	CACNB1 CACNB2 CACNG8	4.61e-06	12	59	3	GO:1990454
GeneOntologyCellularComponent	BAK complex	BAK1 BAX	7.83e-06	2	59	2	GO:0097145
GeneOntologyCellularComponent	voltage-gated calcium channel complex	CACNB1 CACNB2 CACNG8 CACNA1I	8.55e-06	46	59	4	GO:0005891
GeneOntologyCellularComponent	calcium channel complex	CACNB1 CACNB2 CACNG8 CACNA1I	5.39e-05	73	59	4	GO:0034704
GeneOntologyCellularComponent	Bcl-2 family protein complex	BAK1 BAX	3.47e-04	10	59	2	GO:0097136
GeneOntologyCellularComponent	low-density lipoprotein particle	MSR1 LSR	9.16e-04	16	59	2	GO:0034362
GeneOntologyCellularComponent	node of Ranvier	SPTBN4 HAPLN2	1.44e-03	20	59	2	GO:0033268
GeneOntologyCellularComponent	T-tubule	CACNB1 CACNB2 CACNG8	1.45e-03	79	59	3	GO:0030315
GeneOntologyCellularComponent	sarcolemma	CACNB1 CACNB2 CACNG8 FKRP	2.04e-03	190	59	4	GO:0042383
Domain	SRCR	MSR1 SSC5D SSC4D LOXL3 CD163	4.74e-09	21	58	5	PF00530
Domain	SR	MSR1 SSC5D SSC4D LOXL3 CD163	1.23e-08	25	58	5	SM00202
Domain	-	MSR1 SSC5D SSC4D LOXL3 CD163	1.23e-08	25	58	5	3.10.250.10
Domain	SRCR_1	MSR1 SSC5D SSC4D LOXL3 CD163	1.52e-08	26	58	5	PS00420
Domain	SRCR_2	MSR1 SSC5D SSC4D LOXL3 CD163	1.52e-08	26	58	5	PS50287
Domain	SRCR-like_dom	MSR1 SSC5D SSC4D LOXL3 CD163	1.52e-08	26	58	5	IPR017448
Domain	SRCR	MSR1 SSC5D SSC4D LOXL3 CD163	1.86e-08	27	58	5	IPR001190
Domain	BIR	BIRC2 BIRC3 BIRC6	1.57e-06	8	58	3	SM00238
Domain	-	BIRC2 BIRC3 BIRC6	1.57e-06	8	58	3	1.10.1170.10
Domain	BIR	BIRC2 BIRC3 BIRC6	1.57e-06	8	58	3	PF00653
Domain	BIR_REPEAT_2	BIRC2 BIRC3 BIRC6	1.57e-06	8	58	3	PS50143
Domain	BIR_rpt	BIRC2 BIRC3 BIRC6	1.57e-06	8	58	3	IPR001370
Domain	BIR_REPEAT_1	BIRC2 BIRC3 BIRC6	1.57e-06	8	58	3	PS01282
Domain	VDCC_L_bsu	CACNB1 CACNB2	5.66e-05	4	58	2	IPR000584
Domain	Mib_Herc2	MIB1 HERC2	5.66e-05	4	58	2	IPR010606
Domain	VGCC_beta4Aa_N	CACNB1 CACNB2	5.66e-05	4	58	2	PF12052
Domain	MIB_HERC2	MIB1 HERC2	5.66e-05	4	58	2	PS51416
Domain	MIB_HERC2	MIB1 HERC2	5.66e-05	4	58	2	PF06701
Domain	-	AREL1 LSR SLAMF9 NTRK1 SEMA3B MYOM3 HAPLN2 TGM6 PLXNB1	1.90e-04	663	58	9	2.60.40.10
Domain	Bcl2_BH2_motif_CS	BAK1 BAX	2.62e-04	8	58	2	IPR020726
Domain	Bcl2_BH3_motif_CS	BAK1 BAX	2.62e-04	8	58	2	IPR020728
Domain	Bcl2_BH1_motif_CS	BAK1 BAX	2.62e-04	8	58	2	IPR020717
Domain	Ig-like_fold	AREL1 LSR SLAMF9 NTRK1 SEMA3B MYOM3 HAPLN2 TGM6 PLXNB1	3.03e-04	706	58	9	IPR013783
Domain	BH1	BAK1 BAX	5.12e-04	11	58	2	PS01080
Domain	Blc2_fam	BAK1 BAX	5.12e-04	11	58	2	IPR026298
Domain	SH3	CACNB1 CACNB2 SH3KBP1 PSTPIP1 SH3D21	5.50e-04	216	58	5	SM00326
Domain	SH3	CACNB1 CACNB2 SH3KBP1 PSTPIP1 SH3D21	5.50e-04	216	58	5	PS50002
Domain	SH3_domain	CACNB1 CACNB2 SH3KBP1 PSTPIP1 SH3D21	5.98e-04	220	58	5	IPR001452
Domain	Bcl-2	BAK1 BAX	6.13e-04	12	58	2	PF00452
Domain	BCL2_FAMILY	BAK1 BAX	7.23e-04	13	58	2	PS50062
Domain	Bcl2-like	BAK1 BAX	7.23e-04	13	58	2	IPR002475
Domain	BH2	BAK1 BAX	7.23e-04	13	58	2	PS01258
Domain	Spectrin_alpha_SH3	PSTPIP1 SH3D21	9.70e-04	15	58	2	IPR013315
Domain	CARD	BIRC2 BIRC3	1.11e-03	16	58	2	SM00114
Domain	BH3	BAK1 BAX	1.25e-03	17	58	2	PS01259
Domain	ZZ	MIB1 HERC2	1.40e-03	18	58	2	PF00569
Domain	ZF_ZZ_2	MIB1 HERC2	1.40e-03	18	58	2	PS50135
Domain	ZF_ZZ_1	MIB1 HERC2	1.40e-03	18	58	2	PS01357
Domain	Wnt	WNT5B WNT9A	1.57e-03	19	58	2	IPR005817
Domain	Znf_ZZ	MIB1 HERC2	1.57e-03	19	58	2	IPR000433
Domain	Wnt_CS	WNT5B WNT9A	1.57e-03	19	58	2	IPR018161
Domain	wnt	WNT5B WNT9A	1.57e-03	19	58	2	PF00110
Domain	WNT1	WNT5B WNT9A	1.57e-03	19	58	2	SM00097
Domain	WNT1	WNT5B WNT9A	1.57e-03	19	58	2	PS00246
Domain	ZnF_ZZ	MIB1 HERC2	1.57e-03	19	58	2	SM00291
Domain	SH3_1	CACNB1 CACNB2 SH3KBP1 PSTPIP1	1.68e-03	164	58	4	PF00018
Domain	IG	LSR SLAMF9 NTRK1 SEMA3B MYOM3 HAPLN2	1.90e-03	421	58	6	SM00409
Domain	Ig_sub	LSR SLAMF9 NTRK1 SEMA3B MYOM3 HAPLN2	1.90e-03	421	58	6	IPR003599
Domain	Guanylate_kin	CACNB1 CACNB2	2.94e-03	26	58	2	PF00625
Domain	GK/Ca_channel_bsu	CACNB1 CACNB2	2.94e-03	26	58	2	IPR008145
Domain	Guanylate_kin-like_dom	CACNB1 CACNB2	2.94e-03	26	58	2	IPR008144
Domain	GuKc	CACNB1 CACNB2	2.94e-03	26	58	2	SM00072
Domain	HECT	AREL1 HERC2	3.16e-03	27	58	2	PF00632
Domain	HECTc	AREL1 HERC2	3.16e-03	27	58	2	SM00119
Domain	HECT_dom	AREL1 HERC2	3.16e-03	27	58	2	IPR000569
Domain	THIOL_PROTEASE_HIS	TINAGL1 CAPN10	3.16e-03	27	58	2	PS00639
Domain	HECT	AREL1 HERC2	3.16e-03	27	58	2	PS50237
Domain	CARD	BIRC2 BIRC3	3.40e-03	28	58	2	PF00619
Domain	Pept_cys_AS	TINAGL1 CAPN10	3.40e-03	28	58	2	IPR000169
Domain	IG_LIKE	LSR SLAMF9 NTRK1 SEMA3B MYOM3 HAPLN2	4.08e-03	491	58	6	PS50835
Domain	Ig_E-set	AREL1 TGM6 PLXNB1	4.14e-03	104	58	3	IPR014756
Domain	CARD	BIRC2 BIRC3	4.16e-03	31	58	2	IPR001315
Domain	Sema	SEMA3B PLXNB1	4.16e-03	31	58	2	SM00630
Domain	Semap_dom	SEMA3B PLXNB1	4.16e-03	31	58	2	IPR001627
Domain	Sema	SEMA3B PLXNB1	4.16e-03	31	58	2	PF01403
Domain	SEMA	SEMA3B PLXNB1	4.16e-03	31	58	2	PS51004
Domain	PSI	SEMA3B PLXNB1	4.43e-03	32	58	2	PF01437
Domain	Plexin_repeat	SEMA3B PLXNB1	4.43e-03	32	58	2	IPR002165
Domain	Ig-like_dom	LSR SLAMF9 NTRK1 SEMA3B MYOM3 HAPLN2	4.58e-03	503	58	6	IPR007110
Domain	CARD	BIRC2 BIRC3	4.70e-03	33	58	2	PS50209
Domain	PSI	SEMA3B PLXNB1	8.25e-03	44	58	2	IPR016201
Domain	PSI	SEMA3B PLXNB1	8.99e-03	46	58	2	SM00423
Pathway	BIOCARTA_MITOCHONDRIA_PATHWAY	BAK1 BAX BIRC2 BIRC3	2.31e-07	19	41	4	M16257
Pathway	BIOCARTA_MITOCHONDRIA_PATHWAY	BAK1 BAX BIRC2 BIRC3	3.56e-07	21	41	4	MM1484
Pathway	WP_FATTY_ACIDS_AND_LIPOPROTEINS_TRANSPORT_IN_HEPATOCYTES	MSR1 SSC5D LSR SSC4D SH3KBP1 MIB1 LOXL3 PSTPIP1 CD163	1.14e-06	381	41	9	M48063
Pathway	REACTOME_PHASE_0_RAPID_DEPOLARISATION	CACNB1 CACNB2 CACNG8	1.27e-06	8	41	3	MM15197
Pathway	REACTOME_PHASE_2_PLATEAU_PHASE	CACNB1 CACNB2 CACNG8	8.13e-06	14	41	3	MM15198
Pathway	REACTOME_PHASE_2_PLATEAU_PHASE	CACNB1 CACNB2 CACNG8	1.01e-05	15	41	3	M27456
Pathway	REACTOME_REGULATED_NECROSIS	BAK1 BAX BIRC2 BIRC3	2.50e-05	59	41	4	M41803
Pathway	REACTOME_REGULATED_NECROSIS	BAK1 BAX BIRC2 BIRC3	2.50e-05	59	41	4	MM15169
Pathway	REACTOME_NCAM_SIGNALING_FOR_NEURITE_OUT_GROWTH	SPTBN4 CACNB1 CACNB2 CACNA1I	3.24e-05	63	41	4	M11187
Pathway	KEGG_MEDICUS_REFERENCE_CA2_ENTRY_VOLTAGE_GATED_CA2_CHANNEL	CACNB1 CACNB2 CACNA1I	5.02e-05	25	41	3	M47948
Pathway	REACTOME_PHASE_0_RAPID_DEPOLARISATION	CACNB1 CACNB2 CACNG8	1.07e-04	32	41	3	M27455
Pathway	KEGG_APOPTOSIS	NTRK1 BAX BIRC2 BIRC3	1.15e-04	87	41	4	M8492
Pathway	WP_APOPTOSIS	BAK1 BAX BIRC2 BIRC3	1.20e-04	88	41	4	M39654
Pathway	WP_APOPTOSIS_MODULATION_AND_SIGNALING	BAK1 BAX BIRC2 BIRC3	1.43e-04	92	41	4	M39664
Pathway	WP_SMALL_CELL_LUNG_CANCER	BAK1 BAX BIRC2 BIRC3	1.69e-04	96	41	4	M39834
Pathway	KEGG_MEDICUS_PATHOGEN_EBV_BARF1_TO_INTRINSIC_APOPTOTIC_PATHWAY	BAK1 BAX	1.72e-04	7	41	2	M47577
Pathway	REACTOME_RELEASE_OF_APOPTOTIC_FACTORS_FROM_THE_MITOCHONDRIA	BAK1 BAX	1.72e-04	7	41	2	MM14484
Pathway	REACTOME_RELEASE_OF_APOPTOTIC_FACTORS_FROM_THE_MITOCHONDRIA	BAK1 BAX	1.72e-04	7	41	2	M26905
Pathway	KEGG_MEDICUS_PATHOGEN_HIV_TAT_NEF_TO_CROSSTALK_BETWEEN_EXTRINSIC_AND_INTRINSIC_APOPTOTIC_PATHWAYS	BAK1 BAX	2.29e-04	8	41	2	M47571
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_SOD1_TO_INTRINSIC_APOPTOTIC_PATHWAY	BAK1 BAX	2.29e-04	8	41	2	M47740
Pathway	REACTOME_NCAM1_INTERACTIONS	CACNB1 CACNB2 CACNA1I	2.42e-04	42	41	3	M7169
Pathway	REACTOME_MUSCLE_CONTRACTION	CACNB1 CACNB2 CACNG8 PXN CACNA1I	2.90e-04	203	41	5	M5485
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_TP53_TO_TRANSCRIPTION	BAK1 BAX	2.93e-04	9	41	2	M47437
Pathway	KEGG_PATHWAYS_IN_CANCER	WNT5B NTRK1 WNT9A BAX BIRC2 BIRC3	3.26e-04	325	41	6	M12868
Pathway	REACTOME_NUCLEOTIDE_BINDING_DOMAIN_LEUCINE_RICH_REPEAT_CONTAINING_RECEPTOR_NLR_SIGNALING_PATHWAYS	BIRC2 BIRC3 PSTPIP1	3.39e-04	47	41	3	MM14664
Pathway	KEGG_MEDICUS_PATHOGEN_EBV_EBNA3C_TO_P53_MEDIATED_TRANSCRIPTION	BAK1 BAX	3.66e-04	10	41	2	M47491
Pathway	KEGG_MEDICUS_PATHOGEN_EBV_EBNA1_TO_P53_MEDIATED_TRANSCRIPTION	BAK1 BAX	3.66e-04	10	41	2	M47477
Pathway	PID_CASPASE_PATHWAY	BAX BIRC2 BIRC3	4.32e-04	51	41	3	M220
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_CROSSTALK_BETWEEN_EXTRINSIC_AND_INTRINSIC_APOPTOTIC_PATHWAYS	BAK1 BAX	4.46e-04	11	41	2	M47693
Pathway	REACTOME_PRESYNAPTIC_DEPOLARIZATION_AND_CALCIUM_CHANNEL_OPENING	CACNB1 CACNB2	4.46e-04	11	41	2	MM14498
Pathway	REACTOME_PRESYNAPTIC_DEPOLARIZATION_AND_CALCIUM_CHANNEL_OPENING	CACNB1 CACNB2	4.46e-04	11	41	2	M26913
Pathway	KEGG_MEDICUS_PATHOGEN_HSV_GD_TO_HVEM_NFKB_SIGNALING_PATHWAY	BIRC2 BIRC3	5.35e-04	12	41	2	M47600
Pathway	SA_PROGRAMMED_CELL_DEATH	BAK1 BAX	5.35e-04	12	41	2	M13096
Pathway	REACTOME_NUCLEOTIDE_BINDING_DOMAIN_LEUCINE_RICH_REPEAT_CONTAINING_RECEPTOR_NLR_SIGNALING_PATHWAYS	BIRC2 BIRC3 PSTPIP1	5.69e-04	56	41	3	M1074
Pathway	WP_CANCER_PATHWAYS	WNT5B NTRK1 WNT9A BAK1 BAX BIRC2 BIRC3	5.80e-04	507	41	7	M48302
Pathway	KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS	BIRC2 BIRC3 HERC2 BIRC6	6.19e-04	135	41	4	M15247
Pathway	WP_MITOCHONDRIAL_FATTY_ACID_SYNTHESIS_AND_RESPIRATION	MIB1 BAX	6.31e-04	13	41	2	M48341
Pathway	KEGG_MEDICUS_REFERENCE_INTRINSIC_APOPTOTIC_PATHWAY	BAK1 BAX	6.31e-04	13	41	2	M47434
Pathway	WP_MAPK_SIGNALING	CACNB1 CACNB2 CACNG8 NTRK1 CACNA1I	6.97e-04	246	41	5	M39597
Pathway	REACTOME_PROGRAMMED_CELL_DEATH	BAK1 BAX BIRC2 BIRC3	7.48e-04	142	41	4	MM15178
Pathway	KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY	BIRC2 BIRC3 PSTPIP1	7.67e-04	62	41	3	M15569
Pathway	KEGG_MEDICUS_REFERENCE_CROSSTALK_BETWEEN_EXTRINSIC_AND_INTRINSIC_APOPTOTIC_PATHWAYS	BAK1 BAX	8.46e-04	15	41	2	M47448
Pathway	WP_PROSURVIVAL_SIGNALING_OF_NEUROPROTECTIN_D1	BAX BIRC3	8.46e-04	15	41	2	M45549
Pathway	PID_P75_NTR_PATHWAY	NTRK1 BIRC2 BIRC3	1.00e-03	68	41	3	M153
Pathway	KEGG_MAPK_SIGNALING_PATHWAY	CACNB1 CACNB2 CACNG8 NTRK1 CACNA1I	1.01e-03	267	41	5	M10792
Pathway	REACTOME_TNF_RECEPTOR_SUPERFAMILY_TNFSF_MEMBERS_MEDIATING_NON_CANONICAL_NF_KB_PATHWAY	BIRC2 BIRC3	1.09e-03	17	41	2	M27561
Pathway	REACTOME_APOPTOTIC_FACTOR_MEDIATED_RESPONSE	BAK1 BAX	1.09e-03	17	41	2	MM14490
Pathway	REACTOME_TNF_RECEPTOR_SUPERFAMILY_TNFSF_MEMBERS_MEDIATING_NON_CANONICAL_NF_KB_PATHWAY	BIRC2 BIRC3	1.23e-03	18	41	2	MM15275
Pathway	WP_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY	CACNB1 CACNB2 CACNG8	1.28e-03	74	41	3	M39462
Pathway	KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC	CACNB1 CACNB2 CACNG8	1.28e-03	74	41	3	M16376
Pathway	REACTOME_MUSCLE_CONTRACTION	CACNB1 CACNB2 CACNG8 PXN	1.31e-03	165	41	4	MM15026
Pathway	REACTOME_TICAM1_RIP1_MEDIATED_IKK_COMPLEX_RECRUITMENT	BIRC2 BIRC3	1.37e-03	19	41	2	M27020
Pathway	SA_CASPASE_CASCADE	BIRC2 BIRC3	1.37e-03	19	41	2	M7997
Pathway	KEGG_MEDICUS_REFERENCE_WNT_SIGNALING_MODULATION_WNT_ACYLATION	WNT5B WNT9A	1.37e-03	19	41	2	M47836
Pathway	WP_NANOMATERIAL_INDUCED_APOPTOSIS	BAK1 BAX	1.52e-03	20	41	2	M39479
Pathway	REACTOME_APOPTOTIC_FACTOR_MEDIATED_RESPONSE	BAK1 BAX	1.52e-03	20	41	2	M26909
Pathway	PID_P73PATHWAY	NTRK1 BAK1 BAX	1.55e-03	79	41	3	M19
Pathway	KEGG_CARDIAC_MUSCLE_CONTRACTION	CACNB1 CACNB2 CACNG8	1.55e-03	79	41	3	M17673
Pathway	KEGG_MEDICUS_REFERENCE_CARDIAC_TYPE_VGCC_RYR_SIGNALING	CACNB1 CACNB2	1.67e-03	21	41	2	M47950
Pathway	KEGG_MEDICUS_REFERENCE_SKELETAL_TYPE_VGCC_RYR_SIGNALING	CACNB1 CACNB2	1.67e-03	21	41	2	M47949
Pathway	KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM	CACNB1 CACNB2 CACNG8	1.79e-03	83	41	3	M8728
Pathway	WP_APOPTOSIS	BAX BIRC2 BIRC3	1.79e-03	83	41	3	MM15972
Pathway	BIOCARTA_CASPASE_PATHWAY	BIRC2 BIRC3	1.84e-03	22	41	2	M17902
Pathway	REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1	BIRC2 BIRC3	2.01e-03	23	41	2	M1003
Pathway	REACTOME_TNFR1_INDUCED_PROAPOPTOTIC_SIGNALING	BIRC2 BIRC3	2.01e-03	23	41	2	MM15177
Pathway	REACTOME_PYROPTOSIS	BAK1 BAX	2.19e-03	24	41	2	MM15212
Pathway	KEGG_DILATED_CARDIOMYOPATHY	CACNB1 CACNB2 CACNG8	2.25e-03	90	41	3	M835
Pathway	BIOCARTA_CASPASE_PATHWAY	BIRC2 BIRC3	2.37e-03	25	41	2	MM1359
Pathway	REACTOME_WNT_LIGAND_BIOGENESIS_AND_TRAFFICKING	WNT5B WNT9A	2.37e-03	25	41	2	MM14940
Pathway	WP_REGULATION_OF_APOPTOSIS_BY_PARATHYROID_HORMONERELATED_PROTEIN	BAK1 BAX	2.37e-03	25	41	2	M39533
Pathway	REACTOME_TNFR1_INDUCED_PROAPOPTOTIC_SIGNALING	BIRC2 BIRC3	2.37e-03	25	41	2	M27435
Pathway	REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1	BIRC2 BIRC3	2.37e-03	25	41	2	MM15646
Pathway	WP_TNFALPHA_SIGNALING	BAX BIRC2 BIRC3	2.40e-03	92	41	3	M39662
Pathway	REACTOME_WNT_LIGAND_BIOGENESIS_AND_TRAFFICKING	WNT5B WNT9A	2.57e-03	26	41	2	M27239
Pathway	REACTOME_PYROPTOSIS	BAK1 BAX	2.77e-03	27	41	2	M41804
Pathway	REACTOME_BINDING_AND_UPTAKE_OF_LIGANDS_BY_SCAVENGER_RECEPTORS	MSR1 SSC5D CD163	2.87e-03	98	41	3	M27152
Pathway	KEGG_MEDICUS_REFERENCE_WNT_SIGNALING_MODULATION_WNT_INHIBITOR	WNT5B WNT9A	2.97e-03	28	41	2	M47835
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_PTCH1_TO_HEDGEHOG_SIGNALING_PATHWAY	WNT5B WNT9A	3.19e-03	29	41	2	M47372
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_SMO_TO_HEDGEHOG_SIGNALING_PATHWAY	WNT5B WNT9A	3.19e-03	29	41	2	M47377
Pathway	BIOCARTA_DEATH_PATHWAY	BIRC2 BIRC3	3.19e-03	29	41	2	M14971
Pathway	REACTOME_PROGRAMMED_CELL_DEATH	BAK1 BAX BIRC2 BIRC3	3.20e-03	211	41	4	M27436
Pathway	REACTOME_CARDIAC_CONDUCTION	CACNB1 CACNB2 CACNG8	3.30e-03	103	41	3	MM15196
Pathway	PID_CD40_PATHWAY	BIRC2 BIRC3	3.64e-03	31	41	2	M45
Pathway	REACTOME_APOPTOSIS	BAK1 BAX BIRC2	3.77e-03	108	41	3	MM14471
Pathway	WP_REGUCALCIN_IN_PROXIMAL_TUBULE_EPITHELIAL_KIDNEY_CELLS	BAK1 BAX	3.87e-03	32	41	2	M39893
Pathway	REACTOME_RIPK1_MEDIATED_REGULATED_NECROSIS	BIRC2 BIRC3	3.87e-03	32	41	2	M29666
Pathway	WP_DNA_DAMAGE_RESPONSE_ONLY_ATM_DEPENDENT	WNT5B BAK1 BAX	3.97e-03	110	41	3	M39492
Pathway	REACTOME_TNFR1_INDUCED_NF_KAPPA_B_SIGNALING_PATHWAY	BIRC2 BIRC3	4.12e-03	33	41	2	M27438
Pathway	REACTOME_TNFR1_INDUCED_NF_KAPPA_B_SIGNALING_PATHWAY	BIRC2 BIRC3	4.12e-03	33	41	2	MM15180
Pathway	REACTOME_NOD1_2_SIGNALING_PATHWAY	BIRC2 BIRC3	4.12e-03	33	41	2	MM14663
Pathway	WP_GASTRIN_SIGNALING	PXN BIRC2 BIRC3	4.50e-03	115	41	3	M39866
Pathway	WP_PHOTODYNAMIC_THERAPYINDUCED_NFKB_SURVIVAL_SIGNALING	BIRC2 BIRC3	4.62e-03	35	41	2	M39529
Pathway	REACTOME_RIPK1_MEDIATED_REGULATED_NECROSIS	BIRC2 BIRC3	4.62e-03	35	41	2	MM15168
Pathway	REACTOME_NOD1_2_SIGNALING_PATHWAY	BIRC2 BIRC3	4.88e-03	36	41	2	M1059
Pathway	KEGG_MEDICUS_VARIANT_FZD7_OVEREXPRESSION_TO_WNT_SIGNALING_PATHWAY	WNT5B WNT9A	5.15e-03	37	41	2	M47411
Pathway	WP_PHOTODYNAMIC_THERAPYINDUCED_HIF1_SURVIVAL_SIGNALING	BAK1 BAX	5.43e-03	38	41	2	M39707
Pathway	PID_FAS_PATHWAY	BIRC2 BIRC3	5.43e-03	38	41	2	M94
Pathway	REACTOME_NERVOUS_SYSTEM_DEVELOPMENT	SPTBN4 CACNB1 CACNB2 SH3KBP1 CACNA1I PLXNB1	5.98e-03	575	41	6	M29853
Pathway	REACTOME_INTRINSIC_PATHWAY_FOR_APOPTOSIS	BAK1 BAX	6.00e-03	40	41	2	MM14473
Pathway	REACTOME_CARDIAC_CONDUCTION	CACNB1 CACNB2 CACNG8	6.33e-03	130	41	3	M27454
Pubmed	The Birc6 (Bruce) gene regulates p53 and the mitochondrial pathway of apoptosis and is essential for mouse embryonic development.	BAK1 BAX BIRC2 BIRC6	2.79e-10	7	60	4	15640352
Pubmed	Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activation.	BAK1 BAX BIRC2 BIRC3	4.68e-08	21	60	4	22365665
Pubmed	Monomerization of cytosolic mature smac attenuates interaction with IAPs and potentiation of caspase activation.	BIRC2 BIRC3 BIRC6	4.87e-08	5	60	3	20957035
Pubmed	The inhibitors of apoptosis (IAPs) and their emerging role in cancer.	BIRC2 BIRC3 BIRC6	1.70e-07	7	60	3	9916987
Pubmed	Critical function of endogenous XIAP in regulating caspase activation during sympathetic neuronal apoptosis.	BAX BIRC2 BIRC3	2.72e-07	8	60	3	14623868
Pubmed	The proapoptotic activities of Bax and Bak limit the size of the neural stem cell pool.	BAK1 BAX	2.93e-06	2	60	2	14657169
Pubmed	Sphingolipid metabolism cooperates with BAK and BAX to promote the mitochondrial pathway of apoptosis.	BAK1 BAX	2.93e-06	2	60	2	22385963
Pubmed	Bax dimerizes via a symmetric BH3:groove interface during apoptosis.	BAK1 BAX	2.93e-06	2	60	2	22015607
Pubmed	Differential retrotranslocation of mitochondrial Bax and Bak.	BAK1 BAX	2.93e-06	2	60	2	25378477
Pubmed	Localized hypoxia within the subgranular zone determines the early survival of newborn hippocampal granule cells.	BAK1 BAX	2.93e-06	2	60	2	26476335
Pubmed	Interaction of F1L with the BH3 domain of Bak is responsible for inhibiting vaccinia-induced apoptosis.	BAK1 BAX	2.93e-06	2	60	2	16439990
Pubmed	Apoptotic pore formation is associated with in-plane insertion of Bak or Bax central helices into the mitochondrial outer membrane.	BAK1 BAX	2.93e-06	2	60	2	25228770
Pubmed	Denervation-induced mitochondrial dysfunction and autophagy in skeletal muscle of apoptosis-deficient animals.	BAK1 BAX	2.93e-06	2	60	2	22673615
Pubmed	Single-cell time series analysis reveals the dynamics of HSPC response to inflammation.	BAK1 BAX	2.93e-06	2	60	2	38110222
Pubmed	The Isopeptidase Inhibitor G5 Triggers a Caspase-independent Necrotic Death in Cells Resistant to Apoptosis: A COMPARATIVE STUDY WITH THE PROTEASOME INHIBITOR BORTEZOMIB.	BAK1 BAX	2.93e-06	2	60	2	19139105
Pubmed	The oncolytic peptide LTX-315 kills cancer cells through Bax/Bak-regulated mitochondrial membrane permeabilization.	BAK1 BAX	2.93e-06	2	60	2	26378049
Pubmed	Cellular inhibitors of apoptosis proteins cIAP1 and cIAP2 are increased after labour in foetal membranes and myometrium and are essential for TNF-α-induced expression of pro-labour mediators.	BIRC2 BIRC3	2.93e-06	2	60	2	25046208
Pubmed	Bax targeting to mitochondria occurs via both tail anchor-dependent and -independent mechanisms.	BAK1 BAX	2.93e-06	2	60	2	18437166
Pubmed	Pro-apoptotic Bax is the major and Bak an auxiliary effector in cytokine deprivation-induced mast cell apoptosis.	BAK1 BAX	2.93e-06	2	60	2	21364649
Pubmed	Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis.	BAK1 BAX	2.93e-06	2	60	2	12244308
Pubmed	BAX Activation: Mutations Near Its Proposed Non-canonical BH3 Binding Site Reveal Allosteric Changes Controlling Mitochondrial Association.	BAK1 BAX	2.93e-06	2	60	2	30970242
Pubmed	Platelet senescence is regulated by an internal timer, not damage inflicted by hits.	BAK1 BAX	2.93e-06	2	60	2	20530288
Pubmed	Paradoxical implication of BAX/BAK in the persistence of tetraploid cells.	BAK1 BAX	2.93e-06	2	60	2	34725331
Pubmed	Bax and Bak function as the outer membrane component of the mitochondrial permeability pore in regulating necrotic cell death in mice.	BAK1 BAX	2.93e-06	2	60	2	23991283
Pubmed	Baculoviral inhibitors of apoptosis repeat containing (BIRC) proteins fine-tune TNF-induced nuclear factor κB and c-Jun N-terminal kinase signalling in mouse pancreatic beta cells.	BIRC2 BIRC3	2.93e-06	2	60	2	23250032
Pubmed	Betulinic acid induces Bax/Bak-independent cytochrome c release in human nasopharyngeal carcinoma cells.	BAK1 BAX	2.93e-06	2	60	2	22526391
Pubmed	Autophagic cell death is dependent on lysosomal membrane permeability through Bax and Bak.	BAK1 BAX	2.93e-06	2	60	2	29148970
Pubmed	Rare somatic mutation of pro-apoptotic BAX and BAK genes in common human cancers.	BAK1 BAX	2.93e-06	2	60	2	23389372
Pubmed	MCMV-mediated inhibition of the pro-apoptotic Bak protein is required for optimal in vivo replication.	BAK1 BAX	2.93e-06	2	60	2	23468630
Pubmed	Chlamydia trachomatis infection inhibits both Bax and Bak activation induced by staurosporine.	BAK1 BAX	2.93e-06	2	60	2	15322047
Pubmed	Distribution of voltage-dependent calcium channel beta subunits in the hippocampus of patients with temporal lobe epilepsy.	CACNB1 CACNB2	2.93e-06	2	60	2	10465427
Pubmed	Cell-specific modulation of mitochondrial respiration and metabolism by the pro-apoptotic Bcl-2 family members Bax and Bak.	BAK1 BAX	2.93e-06	2	60	2	38001340
Pubmed	Chelerythrine induces apoptosis through a Bax/Bak-independent mitochondrial mechanism.	BAK1 BAX	2.93e-06	2	60	2	18230621
Pubmed	[Inhibitory effect of RNA interference targeting BaxBak on apoptosis of human granulosa cells].	BAK1 BAX	2.93e-06	2	60	2	20034877
Pubmed	Self-termination of the terminator.	BIRC2 BIRC3	2.93e-06	2	60	2	19008929
Pubmed	Cellular inhibitors of apoptosis are global regulators of NF-κB and MAPK activation by members of the TNF family of receptors.	BIRC2 BIRC3	2.93e-06	2	60	2	22434933
Pubmed	Bak and Bax are non-redundant during infection- and DNA damage-induced apoptosis.	BAK1 BAX	2.93e-06	2	60	2	17235284
Pubmed	Escherichia coli subtilase cytotoxin induces apoptosis regulated by host Bcl-2 family proteins Bax/Bak.	BAK1 BAX	2.93e-06	2	60	2	20713620
Pubmed	ER stress modulates cellular metabolism.	BAK1 BAX	2.93e-06	2	60	2	21241252
Pubmed	Age-related hearing loss in C57BL/6J mice is mediated by Bak-dependent mitochondrial apoptosis.	BAK1 BAX	2.93e-06	2	60	2	19901338
Pubmed	Bak and Bax function to limit adenovirus replication through apoptosis induction.	BAK1 BAX	2.93e-06	2	60	2	11932420
Pubmed	Nuclear cIAP1 overexpression is a tumor stage- and grade-independent predictor of poor prognosis in human bladder cancer patients.	BIRC2 BIRC3	2.93e-06	2	60	2	21795072
Pubmed	BH3-in-groove dimerization initiates and helix 9 dimerization expands Bax pore assembly in membranes.	BAK1 BAX	2.93e-06	2	60	2	26702098
Pubmed	Interaction of HCCR-1 and Bax in breast cancer.	LETMD1 BAX	2.93e-06	2	60	2	31424657
Pubmed	Bax deficiency prolongs cerebellar neurogenesis, accelerates medulloblastoma formation and paradoxically increases both malignancy and differentiation.	BAK1 BAX	2.93e-06	2	60	2	22710714
Pubmed	BIRC2-BIRC3 amplification: a potentially druggable feature of a subset of head and neck cancers in patients with Fanconi anemia.	BIRC2 BIRC3	2.93e-06	2	60	2	34997070
Pubmed	Association of Bax and Bak homo-oligomers in mitochondria. Bax requirement for Bak reorganization and cytochrome c release.	BAK1 BAX	2.93e-06	2	60	2	12454021
Pubmed	The multidomain proapoptotic molecules Bax and Bak are directly activated by heat.	BAK1 BAX	2.93e-06	2	60	2	16330765
Pubmed	Identification of an activation site in Bak and mitochondrial Bax triggered by antibodies.	BAK1 BAX	2.93e-06	2	60	2	27217060
Pubmed	Charge profile analysis reveals that activation of pro-apoptotic regulators Bax and Bak relies on charge transfer mediated allosteric regulation.	BAK1 BAX	2.93e-06	2	60	2	22719244
Pubmed	Loss of the proteins Bak and Bax prevents apoptosis mediated by histone deacetylase inhibitors.	BAK1 BAX	2.93e-06	2	60	2	23966164
Pubmed	Prognostic Significance of the BIRC2-BIRC3 Gene Signature in Head and Neck Squamous Cell Carcinoma.	BIRC2 BIRC3	2.93e-06	2	60	2	35985688
Pubmed	Genomic organization and physical map of the human inhibitors of apoptosis: HIAP1 and HIAP2.	BIRC2 BIRC3	2.93e-06	2	60	2	9892732
Pubmed	Mitochondria-mediated apoptosis by diallyl trisulfide in human prostate cancer cells is associated with generation of reactive oxygen species and regulated by Bax/Bak.	BAK1 BAX	2.93e-06	2	60	2	17513609
Pubmed	Ablation of Bax and Bak protects skeletal muscle against pressure-induced injury.	BAK1 BAX	2.93e-06	2	60	2	29487339
Pubmed	Ubiquitin-Mediated Regulation of RIPK1 Kinase Activity Independent of IKK and MK2.	BIRC2 BIRC3	2.93e-06	2	60	2	29452637
Pubmed	Cellular inhibitors of apoptosis (cIAP) 1 and 2 are increased in placenta from obese pregnant women.	BIRC2 BIRC3	2.93e-06	2	60	2	25113061
Pubmed	Evaluation of Bax and Bak gene mutations and expression in breast cancer.	BAK1 BAX	2.93e-06	2	60	2	24672785
Pubmed	Cell death in the absence of Bax and Bak.	BAK1 BAX	2.93e-06	2	60	2	16676001
Pubmed	Homogeneous Oligomers of Pro-apoptotic BAX Reveal Structural Determinants of Mitochondrial Membrane Permeabilization.	BAK1 BAX	2.93e-06	2	60	2	32533918
Pubmed	Deerpox virus encodes an inhibitor of apoptosis that regulates Bak and Bax.	BAK1 BAX	2.93e-06	2	60	2	21159883
Pubmed	Genomic characterization of the mouse inhibitor of apoptosis protein 1 and 2 genes.	BIRC2 BIRC3	2.93e-06	2	60	2	9441758
Pubmed	Helicobacter pylori vacuolating cytotoxin induces activation of the proapoptotic proteins Bax and Bak, leading to cytochrome c release and cell death, independent of vacuolation.	BAK1 BAX	2.93e-06	2	60	2	16436379
Pubmed	Mitochondrial origins of fractional control in regulated cell death.	BAK1 BAX	2.93e-06	2	60	2	30899020
Pubmed	Maintenance of the relative proportion of oligodendrocytes to axons even in the absence of BAX and BAK.	BAK1 BAX	2.93e-06	2	60	2	20128842
Pubmed	BCL-2 proteins and apoptosis: Recent insights and unknowns.	BAK1 BAX	2.93e-06	2	60	2	28676391
Pubmed	Endogenous BAX and BAK form mosaic rings of variable size and composition on apoptotic mitochondria.	BAK1 BAX	2.93e-06	2	60	2	38503846
Pubmed	The role of cell death in sexually dimorphic muscle development: male-specific muscles are retained in female bax/bak knockout mice.	BAK1 BAX	2.93e-06	2	60	2	18563702
Pubmed	c-IAP1 and c-IAP2 redundancy differs between T and B cells.	BIRC2 BIRC3	2.93e-06	2	60	2	23799077
Pubmed	Targeted ablation of the cellular inhibitor of apoptosis 1 (cIAP1) attenuates denervation-induced skeletal muscle atrophy.	BIRC2 BIRC3	2.93e-06	2	60	2	31126323
Pubmed	A nonapoptotic role for BAX and BAK in eicosanoid metabolism.	BAK1 BAX	2.93e-06	2	60	2	25815636
Pubmed	Brain and testicular tumors in mice with progenitor cells lacking BAX and BAK.	BAK1 BAX	2.93e-06	2	60	2	22986529
Pubmed	Suppression of apoptosis, crypt hyperplasia, and altered differentiation in the colonic epithelia of bak-null mice.	BAK1 BAX	2.93e-06	2	60	2	19185578
Pubmed	Cytomegaloviruses inhibit Bak- and Bax-mediated apoptosis with two separate viral proteins.	BAK1 BAX	2.93e-06	2	60	2	19816509
Pubmed	Deficiency in apoptotic effectors Bax and Bak reveals an autophagic cell death pathway initiated by photodamage to the endoplasmic reticulum.	BAK1 BAX	2.93e-06	2	60	2	16874066
Pubmed	Differential plasma membrane targeting of voltage-dependent calcium channel subunits expressed in a polarized epithelial cell line.	CACNB1 CACNB2	2.93e-06	2	60	2	10066897
Pubmed	Sequence differences between BAX and BAK core domains manifest as differences in their interactions with lipids.	BAK1 BAX	2.93e-06	2	60	2	38088212
Pubmed	Bax exists in a dynamic equilibrium between the cytosol and mitochondria to control apoptotic priming.	BAK1 BAX	2.93e-06	2	60	2	23375500
Pubmed	Deficient activation of Bak and Bax confers resistance to gemtuzumab ozogamicin-induced apoptotic cell death in AML.	BAK1 BAX	2.93e-06	2	60	2	19463775
Pubmed	Bax-derived membrane-active peptides act as potent and direct inducers of apoptosis in cancer cells.	BAK1 BAX	2.93e-06	2	60	2	21245196
Pubmed	Inhibiting the mitochondrial fission machinery does not prevent Bax/Bak-dependent apoptosis.	BAK1 BAX	2.93e-06	2	60	2	17015472
Pubmed	Lipid unsaturation promotes BAX and BAK pore activity during apoptosis.	BAK1 BAX	2.93e-06	2	60	2	38830851
Pubmed	Altered mitochondrial morphology and defective protein import reveal novel roles for Bax and/or Bak in skeletal muscle.	BAK1 BAX	2.93e-06	2	60	2	23784543
Pubmed	Subtilase cytotoxin induces apoptosis in HeLa cells by mitochondrial permeabilization via activation of Bax/Bak, independent of C/EBF-homologue protein (CHOP), Ire1alpha or JNK signaling.	BAK1 BAX	2.93e-06	2	60	2	20561923
Pubmed	Apoptosis and autophagy induction in mammalian cells by small interfering RNA knockdown of mRNA capping enzymes.	BAK1 BAX	2.93e-06	2	60	2	18678651
Pubmed	BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis.	BAK1 BAX	2.93e-06	2	60	2	12624178
Pubmed	Asparagine plays a critical role in regulating cellular adaptation to glutamine depletion.	BAK1 BAX	2.93e-06	2	60	2	25242145
Pubmed	Regulation of mitochondrial ceramide distribution by members of the BCL-2 family.	BAK1 BAX	2.93e-06	2	60	2	26059977
Pubmed	Proapoptotic Bak and Bax guard against fatal systemic and organ-specific autoimmune disease.	BAK1 BAX	2.93e-06	2	60	2	23349374
Pubmed	Tumor necrosis factor-alpha induces Bax-Bak interaction and apoptosis, which is inhibited by adenovirus E1B 19K.	BAK1 BAX	2.93e-06	2	60	2	11571294
Pubmed	A comprehensive search for DNA amplification in lung cancer identifies inhibitors of apoptosis cIAP1 and cIAP2 as candidate oncogenes.	BIRC2 BIRC3	2.93e-06	2	60	2	12651874
Pubmed	IAPs: from caspase inhibitors to modulators of NF-kappaB, inflammation and cancer.	BIRC2 BIRC3	2.93e-06	2	60	2	20651737
Pubmed	Bax and Bak have critical roles in ischemic acute kidney injury in global and proximal tubule-specific knockout mouse models.	BAK1 BAX	2.93e-06	2	60	2	23466994
Pubmed	BAX and BAK proteins are required for cyclin-dependent kinase inhibitory drugs to cause apoptosis.	BAK1 BAX	2.93e-06	2	60	2	19056676
Pubmed	Blocking the mitochondrial apoptotic pathway preserves motor neuron viability and function in a mouse model of amyotrophic lateral sclerosis.	BAK1 BAX	2.93e-06	2	60	2	20890041
Pubmed	Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli.	BIRC2 BIRC3	2.93e-06	2	60	2	10797013
Pubmed	Lysosomal membrane permeabilization and cathepsin release is a Bax/Bak-dependent, amplifying event of apoptosis in fibroblasts and monocytes.	BAK1 BAX	2.93e-06	2	60	2	20094062
Pubmed	Mitochondrial apoptosis-induced channel (MAC) function triggers a Bax/Bak-dependent bystander effect.	BAK1 BAX	2.93e-06	2	60	2	21224042
Pubmed	A role for proapoptotic Bax and Bak in T-cell differentiation and transformation.	BAK1 BAX	2.93e-06	2	60	2	20813900
Pubmed	CRISPR/Cas9 Knockout of Bak Mediates Bax Translocation to Mitochondria in response to TNFα/CHX-induced Apoptosis.	BAK1 BAX	2.93e-06	2	60	2	31637258
Interaction	CLEC11A interactions	SEMA3B PEX6 BIRC2 SARDH BIRC6	6.96e-06	96	56	5	int:CLEC11A
Interaction	ENPP1 interactions	FNTB INSC LOXL3 HERC2	1.76e-05	56	56	4	int:ENPP1
Cytoband	11q22	BIRC2 BIRC3	9.17e-05	11	60	2	11q22
Cytoband	Ensembl 112 genes in cytogenetic band chr1q23	SLAMF9 NTRK1 HAPLN2 KLHDC9	2.25e-04	226	60	4	chr1q23
Cytoband	12p13.3	WNT5B CD163	7.14e-04	30	60	2	12p13.3
Cytoband	Xq22.3	NCBP2L RIPPLY1	8.64e-04	33	60	2	Xq22.3
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	SPTBN4 SSC5D LSR CACNG8 FKRP BAX FBXO27	9.10e-04	1192	60	7	chr19q13
GeneFamily	Calcium voltage-gated channel subunits	CACNB1 CACNB2 CACNG8 CACNA1I	3.99e-07	26	43	4	253
GeneFamily	C2-set domain containing\|Immunoglobulin like domain containing\|Scavenger receptors	MSR1 SSC5D SSC4D CD163	4.68e-07	27	43	4	1253
GeneFamily	Ring finger proteins\|Baculoviral IAP repeat containing\|Caspase recruitment domain containing	BIRC2 BIRC3 BIRC6	6.96e-07	8	43	3	419
GeneFamily	BCL2 family	BAK1 BAX	4.94e-04	14	43	2	1057
GeneFamily	Zinc fingers ZZ-type\|Lysine acetyltransferases	MIB1 HERC2	8.25e-04	18	43	2	91
GeneFamily	Wnt family\|Endogenous ligands	WNT5B WNT9A	9.21e-04	19	43	2	360
GeneFamily	Immunoglobulin like domain containing	LSR NTRK1 SEMA3B MYOM3	1.12e-03	193	43	4	594
GeneFamily	Calcium voltage-gated channel subunits\|Membrane associated guanylate kinases	CACNB1 CACNB2	1.73e-03	26	43	2	904
GeneFamily	WD repeat domain containing\|Caspase recruitment domain containing\|Apoptosome	BIRC2 BIRC3	2.30e-03	30	43	2	959
Coexpression	GALI_TP53_TARGETS_APOPTOTIC_UP	BAX BIRC2 BIRC3	6.33e-07	8	60	3	M16490
Coexpression	MACLACHLAN_BRCA1_TARGETS_DN	SEMA3B BAK1 BAX	6.25e-06	16	60	3	M10593
ToppCell	facs-Diaphragm-Limb_Muscle-24m-Myeloid-macrophage\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MSR1 STARD8 CLEC6A SLAMF9 CD163	2.00e-06	153	60	5	4b999892fb797e9f0d391630094f466463299d57
ToppCell	facs-Diaphragm-Limb_Muscle-24m-Myeloid-nan\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MSR1 STARD8 CLEC6A SLAMF9 CD163	2.00e-06	153	60	5	e426db29e4ba83e7930dc88c74fc975b177c9540
ToppCell	facs-Diaphragm-Limb_Muscle-24m-Myeloid\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MSR1 STARD8 CLEC6A SLAMF9 CD163	2.00e-06	153	60	5	668eacd76aad6054bd7d57e3af0b122c2443465f
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Granulocytic\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SPTBN4 SSC5D CACNB2 SARDH SH3D21	2.13e-06	155	60	5	51f6447945389649d99dcf7603b396195c631ead
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Granulocytic-Mast_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SPTBN4 SSC5D CACNB2 SARDH SH3D21	2.13e-06	155	60	5	23dc71cab28094ca0ac4d2baf4e24871ed107781
ToppCell	droplet-Bladder-Unstain-18m-Hematologic-macrophage\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MSR1 CLEC6A SLAMF9 PSTPIP1 CD163	2.34e-06	158	60	5	e5e7b2d609973f1dd4fe7dc62bb69422268ea801
ToppCell	droplet-Bladder-Unstain-18m-Hematologic-leukocyte\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MSR1 CLEC6A SLAMF9 PSTPIP1 CD163	2.42e-06	159	60	5	89b5e895e95cdd654edd471bde9b6887939b3503
ToppCell	droplet-Bladder-Unstain-18m-Hematologic\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MSR1 CLEC6A SLAMF9 PSTPIP1 CD163	2.42e-06	159	60	5	a80b4637a74bcc6f213d584aba2c727a983eedb3
ToppCell	droplet-Heart-4Chambers-18m-Hematologic-leukocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MSR1 CLEC6A SLAMF9 PSTPIP1 CD163	3.55e-06	172	60	5	19ccac3d88382b8b2379d14525b2204c7407cb3b
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Hematologic-leukocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MSR1 CLEC6A SLAMF9 PSTPIP1 CD163	3.65e-06	173	60	5	1ea8b8b89611bebf6acb700fb04a7d38720775a9
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Hematologic-leukocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MSR1 CLEC6A SLAMF9 PSTPIP1 CD163	3.65e-06	173	60	5	9b957dd442f3af0e5fb99f3c93606308a459d485
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Hematologic\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MSR1 CLEC6A SLAMF9 PSTPIP1 CD163	3.65e-06	173	60	5	a0e4d25db186b9f7ff819abc0db68ad58c92ba3b
ToppCell	PND07-Immune-Immune_Myeloid-Monocytic-Macrophage-IM\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MSR1 STARD8 CLEC6A SLAMF9 CD163	4.31e-06	179	60	5	fae869fb0a91428481bf8a9c111dcc639e2b4278
ToppCell	droplet-Fat-SCAT-30m-Epithelial\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WNT5B IQCC MIB1 SLC16A11 PLXNB1	5.33e-06	187	60	5	5fada3c5a58c1890029ccbfff2608b33f8cd2df7
ToppCell	droplet-Fat-SCAT-30m-Epithelial-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WNT5B IQCC MIB1 SLC16A11 PLXNB1	5.33e-06	187	60	5	766e808138fc2cd623c2e6d57fcb5c7378da0e03
ToppCell	droplet-Fat-SCAT-30m-Epithelial-epithelial_cell\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WNT5B IQCC MIB1 SLC16A11 PLXNB1	5.33e-06	187	60	5	f49d06600060deeb2fc1b1da5b93496535f20104
ToppCell	Control_saline-Hematopoietic_Myeloid-Monocytes,_Macrophages\|Control_saline / Treatment groups by lineage, cell group, cell type	MSR1 CLEC6A SLAMF9 PSTPIP1 CD163	7.04e-06	198	60	5	684f2dd5db889f118b5218ee23733cc1361272c2
ToppCell	Control_saline-Hematopoietic_Myeloid-Monocytes,_Macrophages-Monocytes-Macrophages\|Control_saline / Treatment groups by lineage, cell group, cell type	MSR1 CLEC6A SLAMF9 PSTPIP1 CD163	7.04e-06	198	60	5	c15ab0660a6de445a83396cf70860ea39868914d
ToppCell	Control_saline-Hematopoietic_Myeloid\|Control_saline / Treatment groups by lineage, cell group, cell type	MSR1 CLEC6A SLAMF9 PSTPIP1 CD163	7.22e-06	199	60	5	6be92062cce049a4c98f7311f2500bf1468fc267
ToppCell	Frontal_cortex-Hematopoietic-MACROPHAGE\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	MSR1 CLEC6A SLAMF9 CD163	7.63e-06	93	60	4	1a112bd4e5e63826efad0338ce99d7a7ad9c72b9
ToppCell	Frontal_cortex-Hematopoietic-MACROPHAGE-MP1(C1qb)-MACROPHAGE_Macrophage.C1qb.Mrc1_(Resident_macrophage)--\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	MSR1 CLEC6A SLAMF9 CD163	7.63e-06	93	60	4	9c566fc2a8c7630bea28e8e46df55454aa409bc1
ToppCell	Frontal_cortex-Hematopoietic-MACROPHAGE-MP1(C1qb)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	MSR1 CLEC6A SLAMF9 CD163	7.63e-06	93	60	4	d102a0a015a2866e3fe549ac8796b9a0d5923d7e
ToppCell	Frontal_cortex-Hematopoietic-MACROPHAGE-MP1(C1qb)-MACROPHAGE_Macrophage.C1qb.Mrc1_(Resident_macrophage)-\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	MSR1 CLEC6A SLAMF9 CD163	7.63e-06	93	60	4	0967a93dcc72d2d8f12d56de186ec1af55c36001
ToppCell	Frontal_cortex-Hematopoietic-MACROPHAGE-MP1(C1qb)-MACROPHAGE_Macrophage.C1qb.Mrc1_(Resident_macrophage)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	MSR1 CLEC6A SLAMF9 CD163	7.63e-06	93	60	4	613c827a643a7b6d70ef932cfa1762e90bc5a338
ToppCell	Substantia_nigra-Hematopoietic-MACROPHAGE-MP1(C1qb)\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	MSR1 CLEC6A PSTPIP1 CD163	1.83e-05	116	60	4	e93dd059d272e597a30e93f4c0504636f4e6c899
ToppCell	Substantia_nigra-Hematopoietic-MACROPHAGE-MP1(C1qb)-MACROPHAGE_Macrophage.C1qb.Mrc1_(Resident_macrophage)\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	MSR1 CLEC6A PSTPIP1 CD163	1.83e-05	116	60	4	27201cb805fe73b5ec51d7d585d047a4c043e8b0
ToppCell	Substantia_nigra-Hematopoietic-MACROPHAGE\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	MSR1 CLEC6A PSTPIP1 CD163	1.83e-05	116	60	4	d3194bda2e3d5fd021e4015eed98c5888befe03d
ToppCell	Substantia_nigra-Hematopoietic-MACROPHAGE-MP1(C1qb)-MACROPHAGE_Macrophage.C1qb.Mrc1_(Resident_macrophage)-\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	MSR1 CLEC6A PSTPIP1 CD163	1.83e-05	116	60	4	4e84b6f6661bb5ba0fe0de38a23bee9cc3727d94
ToppCell	Substantia_nigra-Hematopoietic-MACROPHAGE-MP1(C1qb)-MACROPHAGE_Macrophage.C1qb.Mrc1_(Resident_macrophage)--\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	MSR1 CLEC6A PSTPIP1 CD163	1.83e-05	116	60	4	15d9a3d8c3cc1f6a1aead03cf84dc876c76b7063
ToppCell	PND01-03-samps-Myeloid-Macrophage-macrophage_-_intermediate_-_unactivated\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	MSR1 CLEC6A SLAMF9 CACNA1I	3.04e-05	132	60	4	617644597726e881cd343e57f6edb5a98473b421
ToppCell	Cerebellum-Hematopoietic-MICROGLIA\|Cerebellum / BrainAtlas - Mouse McCarroll V32	MSR1 CLEC6A SLAMF9 CD163	3.72e-05	139	60	4	75cca1e6c1af289987d5d98455e9c6db81ecdd64
ToppCell	Cerebellum-Hematopoietic-MICROGLIA-MI1(C1qb)-MICROGLIA_Microglia.C1qb.Mrc1-Tmem119_(Resident_macrophage)-\|Cerebellum / BrainAtlas - Mouse McCarroll V32	MSR1 CLEC6A SLAMF9 CD163	3.72e-05	139	60	4	a077ce50f6d6746d80de35abed5b6dc35b1145b9
ToppCell	Cerebellum-Hematopoietic-MICROGLIA-MI1(C1qb)\|Cerebellum / BrainAtlas - Mouse McCarroll V32	MSR1 CLEC6A SLAMF9 CD163	3.72e-05	139	60	4	de34e2f51f6fda638357abb662c111a20b83e70b
ToppCell	Cerebellum-Hematopoietic-MICROGLIA-MI1(C1qb)-MICROGLIA_Microglia.C1qb.Mrc1-Tmem119_(Resident_macrophage)\|Cerebellum / BrainAtlas - Mouse McCarroll V32	MSR1 CLEC6A SLAMF9 CD163	3.72e-05	139	60	4	0ae117308bd10d3a7d2688794c69dc5a31cfca5f
ToppCell	Cerebellum-Hematopoietic-MICROGLIA-MI1(C1qb)-MICROGLIA_Microglia.C1qb.Mrc1-Tmem119_(Resident_macrophage)--\|Cerebellum / BrainAtlas - Mouse McCarroll V32	MSR1 CLEC6A SLAMF9 CD163	3.72e-05	139	60	4	fac6a3100a277efa1db250e0c576be1a0c901e6d
ToppCell	Cerebellum-Hematopoietic\|Cerebellum / BrainAtlas - Mouse McCarroll V32	MSR1 CLEC6A SLAMF9 CD163	3.72e-05	139	60	4	3913c3828ad4cb5c71380519d0cf5f195e53c51d
ToppCell	E18.5-Immune-Immune_Myeloid-Monocytic-Macrophage-IM-IM_prolif\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MSR1 STARD8 CLEC6A CD163	5.54e-05	154	60	4	79ebda35dd1719e157738d7c13e5b8ccc3991f03
ToppCell	3'_v3-Lung-Lymphocytic_T_CD8-Tnaive/CM_CD8\|Lung / Manually curated celltypes from each tissue	LSR INSC CACNA1I TG	5.83e-05	156	60	4	d691a4defda046c1bbcb13ef38ee9abbb628c33c
ToppCell	facs-Limb_Muscle-Muscle_forelimb_and_hindlimb-18m-Myeloid-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MSR1 CLEC6A SLAMF9 PSTPIP1	5.98e-05	157	60	4	c3451b33780499fd62672e7cd71c7e8cb6ccc2c5
ToppCell	facs-Limb_Muscle-Muscle_forelimb_and_hindlimb-18m-Myeloid\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MSR1 CLEC6A SLAMF9 PSTPIP1	5.98e-05	157	60	4	92cd58b62e46b93f90e05657fd201404ccae6ddb
ToppCell	facs-Limb_Muscle-Muscle_forelimb_and_hindlimb-18m-Myeloid-macrophage\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MSR1 CLEC6A SLAMF9 PSTPIP1	5.98e-05	157	60	4	042129d1b514dc4ed8a5f45b52d9c73cf4807636
ToppCell	droplet-Bladder-nan-24m-Hematologic-macrophage\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MSR1 CLEC6A SLAMF9 CD163	6.13e-05	158	60	4	4a9d4706876f6e86fc5d63ad6dc7df1b4a5cfd9e
ToppCell	Frontal_cortex-Hematopoietic\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	MSR1 CLEC6A SLAMF9 CD163	6.43e-05	160	60	4	70ffbe61cfd729519b23569a43d929b117ab8d5e
ToppCell	368C-Myeloid-Macrophage-FABP4+_Macrophage_2\|368C / Donor, Lineage, Cell class and subclass (all cells)	MSR1 PNMA6A SH3D21 CD163	6.43e-05	160	60	4	ac3f56f8ab8efd11c4b4868a828db05c23ac762f
ToppCell	droplet-Mammary_Gland-nan-21m-Myeloid-macrophage\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MSR1 CLEC6A SLAMF9 CD163	6.59e-05	161	60	4	787f91f906756ef570c0d02936c3cdfafb3f7454
ToppCell	droplet-Mammary_Gland-nan-21m-Myeloid\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MSR1 CLEC6A SLAMF9 CD163	6.59e-05	161	60	4	3db97af49520dc8cbafb4454d8afd9d588160e89
ToppCell	droplet-Mammary_Gland-nan-21m-Myeloid-macrophage\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MSR1 CLEC6A SLAMF9 CD163	6.59e-05	161	60	4	f1d258c81bcf0f3c52bd20aa58faa9a5fd888168
ToppCell	Children_(3_yrs)-Mesenchymal-vascular_smooth_muscle_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	TINAGL1 SSC5D HAPLN2 SARDH	6.91e-05	163	60	4	8f24cef152f5965727bbeee116bd26c75cbba82a
ToppCell	facs-Lung-EPCAM-24m-Lymphocytic-T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	B4GALNT4 SH3KBP1 PSTPIP1 FBXO27	7.08e-05	164	60	4	467ad12884b70d243988174ae960ee2b7b6cfb0c
ToppCell	facs-Lung-EPCAM-24m-Lymphocytic-Ly6g5b+_T\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	B4GALNT4 SH3KBP1 PSTPIP1 FBXO27	7.08e-05	164	60	4	4e1861382c9e93856da19303474c8975c19706d2
ToppCell	facs-Diaphragm-Limb_Muscle-3m-Myeloid\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MSR1 CLEC6A SLAMF9 CD163	7.25e-05	165	60	4	518ee34c18065100a2f2c6e407d3a7866b908593
ToppCell	facs-Diaphragm-Limb_Muscle-3m-Myeloid-nan\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MSR1 CLEC6A SLAMF9 CD163	7.25e-05	165	60	4	becb8f726b84509ec29c75b530a3fe757651301d
ToppCell	facs-Diaphragm-Limb_Muscle-3m-Myeloid-macrophage\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MSR1 CLEC6A SLAMF9 CD163	7.25e-05	165	60	4	ae8dd9c00f96590f27ed21cd6314f4577e00e312
ToppCell	5'-GW_trimst-2-SmallIntestine-Hematopoietic-Myeloid-Lymphoid_DC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CLEC6A SLC20A1 BIRC3 REM2	7.42e-05	166	60	4	75d719617c61409860f298ce91cbe3a0aafa0553
ToppCell	facs-Liver-Hepatocytes-24m-Myeloid-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MSR1 CACNB1 CLEC6A CD163	7.42e-05	166	60	4	03a47b8687f54955e84df1edcb230db332c4ca8f
ToppCell	facs-SCAT-Fat-3m-Myeloid-myeloid_cell\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MSR1 STARD8 SLAMF9 CD163	7.42e-05	166	60	4	8395c74db8e4e54af97a3f2b75cb75171140ec31
ToppCell	facs-SCAT-Fat-3m-Myeloid\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MSR1 STARD8 SLAMF9 CD163	7.42e-05	166	60	4	76807edc5620514b53a14be354b84c54c112b8f9
ToppCell	facs-SCAT-Fat-3m-Myeloid-nan\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MSR1 STARD8 SLAMF9 CD163	7.42e-05	166	60	4	645b842b94b8d2f4b26c2623f8589f56bd782c26
ToppCell	facs-Heart-LA-24m-Myeloid-monocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MSR1 CLEC6A SLAMF9 CD163	7.42e-05	166	60	4	2c931d593e189127c31adaf36a3df81d8287bb53
ToppCell	Thalamus-Hematopoietic\|Thalamus / BrainAtlas - Mouse McCarroll V32	MSR1 CLEC6A SLAMF9 CD163	7.42e-05	166	60	4	76d60ac7ac5d1eaf530f0c741d9c48e0bd58396b
ToppCell	facs-Heart-LA-24m-Myeloid-monocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MSR1 CLEC6A SLAMF9 CD163	7.42e-05	166	60	4	9e7a9cb7beeb7015fcaa476a4902883dee99e8c0
ToppCell	facs-Heart-LA-24m-Myeloid\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MSR1 CLEC6A SLAMF9 CD163	7.42e-05	166	60	4	2a3c396deb068066b8c2f85ddd2fa52629776bcd
ToppCell	droplet-Heart-HEART_(LV+RV_ONLY)-30m-Hematologic\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MSR1 CLEC6A SLAMF9 PSTPIP1	7.59e-05	167	60	4	eadb2c2650132446f0d0413792c69a4961ebc350
ToppCell	facs-Lung-24m-Hematologic-lymphocytic-immature_innate_lymphoid_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CACNB1 B4GALNT4 SH3KBP1 FBXO27	7.59e-05	167	60	4	5d1919bea8e5a52ac6fc953caff15509b7142923
ToppCell	facs-Lung-24m-Hematologic-lymphocytic-immature_innate_lymphoid_cell-Ly6g5b+_T\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CACNB1 B4GALNT4 SH3KBP1 FBXO27	7.59e-05	167	60	4	d8f497860d48342a3aaaad328f88e4d55ab4faeb
ToppCell	3'_v3-bone_marrow-Myeloid_Mac-Intermediate_macrophages\|bone_marrow / Manually curated celltypes from each tissue	MSR1 SLAMF9 LOXL3 CD163	7.77e-05	168	60	4	8ade4d098aeecda2d80c1cad1cebe9a063eae948
ToppCell	droplet-Heart-nan-24m-Hematologic\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MSR1 CLEC6A SLAMF9 CD163	7.77e-05	168	60	4	0d505ddda32141b81173daecad11ca6b091688a9
ToppCell	droplet-Heart-4Chambers-21m-Hematologic\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MSR1 CLEC6A SLAMF9 CD163	7.77e-05	168	60	4	8ff4666fdda562913060b1cfa2dfab34e0606794
ToppCell	droplet-Heart-nan-24m-Hematologic-leukocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MSR1 CLEC6A SLAMF9 CD163	7.77e-05	168	60	4	0ef2d8dbcccc812dd0d99769048b95cf06faf023
ToppCell	droplet-Trachea-3m-Hematologic-myeloid-granulocyte\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MSR1 CLEC6A SLAMF9 CD163	7.77e-05	168	60	4	a6992b9cc003e4d45d800767d94de5d7a193fc32
ToppCell	droplet-Heart-nan-24m-Hematologic-leukocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MSR1 CLEC6A SLAMF9 CD163	7.95e-05	169	60	4	018f82b3271f90e29c29e2d733d5ced6919fc42e
ToppCell	facs-SCAT-Fat-18m-Myeloid-myeloid_cell\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MSR1 CLEC6A SLAMF9 BAK1	7.95e-05	169	60	4	1e34a13a450f90b79fcaacd72ad3a7aa21e5eed2
ToppCell	droplet-Heart-4Chambers-18m-Hematologic\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MSR1 CLEC6A SLAMF9 CD163	7.95e-05	169	60	4	ea43002e74076aa03bf688c0a76c07117787d4b5
ToppCell	facs-SCAT-Fat-18m-Myeloid\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MSR1 CLEC6A SLAMF9 BAK1	7.95e-05	169	60	4	dbc6f95b4a0d9bc2a34f649161b83979e5e6fb8e
ToppCell	facs-SCAT-Fat-18m-Myeloid-nan\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MSR1 CLEC6A SLAMF9 BAK1	7.95e-05	169	60	4	4d783e27fd7d25d9c157b98ae7df55acb1e72d4b
ToppCell	droplet-Heart-4Chambers-21m-Hematologic-leukocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MSR1 CLEC6A SLAMF9 CD163	7.95e-05	169	60	4	3296305dc4fa40c466dab56aab4eac302ae3d7f7
ToppCell	droplet-Trachea-nan-3m-Myeloid-granulocyte\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MSR1 CLEC6A SLAMF9 CD163	7.95e-05	169	60	4	58590137dce1420c74c56fce07a1c0151132a37e
ToppCell	droplet-Heart-4Chambers-21m-Hematologic-leukocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MSR1 CLEC6A SLAMF9 CD163	8.13e-05	170	60	4	8ea5ab8c890eb91c5b0aae3996e1d1c61c97f0c7
ToppCell	droplet-Heart-nan-18m-Hematologic-leukocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MSR1 CLEC6A SLAMF9 CD163	8.13e-05	170	60	4	7077eaf68ac859f63d6581d26a95c20d6a04bd28
ToppCell	droplet-Heart-nan-18m-Hematologic\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MSR1 CLEC6A SLAMF9 CD163	8.32e-05	171	60	4	2594ba8236a69461d9786ffcd882c39d0c9d5788
ToppCell	facs-Trachea-18m-Hematologic-myeloid-tracheal_macrophage-macrophage_of_tracheal_l12\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MSR1 CLEC6A SLAMF9 CD163	8.32e-05	171	60	4	26755e43d94e934106fc19ab929e4d34c17d6cba
ToppCell	droplet-Heart-4Chambers-18m-Hematologic-leukocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MSR1 CLEC6A SLAMF9 CD163	8.32e-05	171	60	4	4935a95d11ac997d183fab32cbaad837bf0a512b
ToppCell	droplet-Heart-nan-18m-Hematologic-leukocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MSR1 CLEC6A SLAMF9 CD163	8.32e-05	171	60	4	79b806194df645cccd357520eb6801ab1e93b3c5
ToppCell	E18.5-Immune-Immune_Myeloid-Monocytic-Macrophage-IM\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MSR1 STARD8 CLEC6A CD163	8.51e-05	172	60	4	c96bd3407911df3e3e6d7a3dba786b11814b9598
ToppCell	PND10-Immune-Immune_Myeloid-Monocytic-Macrophage-IM-IM_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MSR1 CLEC6A SLAMF9 CD163	8.51e-05	172	60	4	f0e767a20d93e546ce278db67dbd779cc68af533
ToppCell	droplet-Heart-HEART_(LV+RV_ONLY)-30m-Hematologic-leukocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MSR1 CLEC6A SLAMF9 PSTPIP1	8.51e-05	172	60	4	dd2ab9a5652dc152841d73e25a9e7c40a8faa2a5
ToppCell	Influenza_Severe-CD4+_Tcm\|Influenza_Severe / Disease group and Cell class	LSR SCART1 CACNA1I SARDH	8.51e-05	172	60	4	47865a04968ca28c6ff125159d9a23e37c8b8af1
ToppCell	droplet-Heart-HEART_(LV+RV_ONLY)-30m-Hematologic-leukocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MSR1 CLEC6A SLAMF9 PSTPIP1	8.51e-05	172	60	4	ce0c63fa83d68621445ba3e4d23c8a5e1a4db95e
ToppCell	droplet-Lung-nan-21m-Myeloid-Interstitial_Macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLEC6A SLAMF9 REM2 CD163	8.70e-05	173	60	4	31ea04e65876c42b90245d280f0b6439bfffbace
ToppCell	droplet-Limb_Muscle-MUSCLE-1m-Myeloid-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MSR1 CLEC6A SLAMF9 CD163	8.70e-05	173	60	4	a664dbd7fb55b1c4309fa5f9425bc83924dac545
ToppCell	droplet-Lung-LUNG-1m-Myeloid-Interstitial_Macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPTBN4 CLEC6A SLAMF9 CD163	8.70e-05	173	60	4	26bba58f9fb215d1d155504906cd77e8774f6936
ToppCell	droplet-Lung-LUNG-1m-Myeloid-lung_macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPTBN4 CLEC6A SLAMF9 CD163	8.70e-05	173	60	4	69b404e92aad3e6dff67e75466f073f20a71f13f
ToppCell	droplet-Lung-nan-21m-Myeloid-lung_macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLEC6A SLAMF9 REM2 CD163	8.70e-05	173	60	4	1cff815536f620e32b9805666e1aa711462c2d25
ToppCell	droplet-Limb_Muscle-MUSCLE-1m-Myeloid-macrophage\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MSR1 CLEC6A SLAMF9 CD163	8.70e-05	173	60	4	054f64462b648ba6b4b28b48c716dc01b2ddd790
ToppCell	droplet-Limb_Muscle-MUSCLE-1m-Myeloid\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MSR1 CLEC6A SLAMF9 CD163	8.70e-05	173	60	4	9a8fec9a08bb61456a4ea43ae1316bd3e197a773
ToppCell	AT1_cells-Donor_07\|World / lung cells shred on cell class, cell subclass, sample id	TINAGL1 WNT9A SEMA3B BIRC3	8.70e-05	173	60	4	b29816427428c7053017477f59b828bf1357f3b2
ToppCell	facs-Heart-LA-3m-Myeloid\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MSR1 CLEC6A SLAMF9 CD163	8.90e-05	174	60	4	30c083fe4711735e83dccfd00fcd746ae673d353
ToppCell	facs-Heart-LV-3m-Myeloid-monocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MSR1 CLEC6A SLAMF9 CD163	8.90e-05	174	60	4	54166a0faf748cccb6406c2c268e1e6e21caf6d0
ToppCell	facs-Heart-LA-3m-Myeloid-monocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MSR1 CLEC6A SLAMF9 CD163	8.90e-05	174	60	4	46d19c1144fff19be682b7ba59d4c3e014f79e15
ToppCell	facs-Heart-LA-3m-Myeloid-monocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MSR1 CLEC6A SLAMF9 CD163	8.90e-05	174	60	4	1802a52552256d1e25d8b328ba62dcfe41671900
Drug	gallopamil	CACNB1 CACNB2 LSR CACNG8 CACNA1I BIRC6	1.67e-08	67	57	6	CID000001234
Drug	TN-2	BAK1 BAX BIRC2 BIRC3 PMEL	9.30e-08	45	57	5	CID006852143
Drug	Dendroaspis natriuretic peptide	BAX BIRC2 BIRC3	2.96e-07	6	57	3	ctd:C075597
Drug	Mibefradil	CACNB1 CACNB2 CACNA1I	2.42e-06	11	57	3	DB01388
Drug	5-phenylselenylmethyl-2'-deoxyuridine	BAX BIRC2 BIRC3	2.42e-06	11	57	3	ctd:C558289
Drug	5-methylselenylmethyl-2'-deoxyuridine	BAX BIRC2 BIRC3	2.42e-06	11	57	3	ctd:C558288
Drug	ent-1,3,6,11-tetrahydroxykaur-16-ene-15-one 3,11-diacetate	BAX BIRC2 BIRC3	5.31e-06	14	57	3	ctd:C530049
Drug	Ticlopidine hydrochloride [53885-35-1]; Up 200; 13.4uM; MCF7; HT_HG-U133A	CACNB1 FKRP NTRK1 BIRC3 SARDH TG	7.95e-06	190	57	6	4155_UP
Drug	Verapamil	CACNB1 CACNB2 CACNA1I	8.14e-06	16	57	3	DB00661
Drug	Spectinomycin dihydrochloride [21736-83-4]; Up 200; 9.8uM; MCF7; HT_HG-U133A	MSR1 CACNB2 IQCC FKRP CACNA1I FAM131A	9.22e-06	195	57	6	3327_UP
Drug	Mebhydroline 1,5-naphtalenedisulfonate [6153-33-9]; Down 200; 4.8uM; PC3; HT_HG-U133A	TINAGL1 IQCC FKRP PEX6 PLXNB1 CAPN10	1.04e-05	199	57	6	4211_DN
Drug	lamotrigine	CACNB1 CACNB2 CACNG8 CACNA1I LOXL3	1.07e-05	116	57	5	CID000003878
Drug	Cinildipine	CACNB1 CACNB2 CACNG8 CACNA1I	1.18e-05	56	57	4	CID000002752
Drug	sanguinarine	BAK1 BAX BIRC2 BIRC3	1.55e-05	60	57	4	CID000005154
Drug	nilvadipine	CACNB1 CACNB2 CACNG8 CACNA1I	1.55e-05	60	57	4	CID000004494
Drug	bepridil	CACNB1 CACNB2 CACNG8 CACNA1I BIRC6	1.59e-05	126	57	5	CID000002351
Drug	pimozide	CACNB1 CACNB2 CACNG8 CACNA1I PMEL	1.66e-05	127	57	5	CID000016362
Drug	enzacamene	CACNB1 CACNB2 CACNG8 NTRK1 CACNA1I	1.79e-05	129	57	5	ctd:C038939
Drug	Akt-I-1 compound	BIRC2 BIRC3	1.84e-05	3	57	2	ctd:C501520
Drug	aclacinomycins	BIRC2 BIRC3	1.84e-05	3	57	2	ctd:C011157
Drug	lercanidipine	CACNB1 CACNB2 CACNG8 CACNA1I	1.88e-05	63	57	4	CID000065866
Drug	mibefradil	CACNB1 CACNB2 CACNG8 CACNA1I	2.01e-05	64	57	4	CID000060662
Drug	octylmethoxycinnamate	CACNB1 CACNB2 CACNG8 NTRK1 CACNA1I	2.56e-05	139	57	5	ctd:C118580
Drug	AC1L2AC7	CACNB1 CACNB2 CACNG8 CACNA1I	2.70e-05	69	57	4	CID000068733
Drug	danthron	BAX BIRC2 BIRC3	3.29e-05	25	57	3	ctd:C004315
Drug	thallium	LOXL3 BIRC6 TG	3.29e-05	25	57	3	CID000105005
Drug	CAS 298-57-7	CACNB1 CACNB2 CACNG8 CACNA1I	3.38e-05	73	57	4	CID000002761
Drug	ethosuximide	CACNB1 CACNB2 CACNG8 CACNA1I	3.56e-05	74	57	4	CID000003291
Drug	gamma-secretase inhibitor I	BIRC2 BIRC3	3.68e-05	4	57	2	CID011754711
Drug	nisoldipine	CACNB1 CACNB2 CACNG8 CACNA1I	4.39e-05	78	57	4	CID000004499
Drug	butylparaben	CACNB1 CACNB2 CACNG8 NTRK1 CACNA1I	4.59e-05	157	57	5	ctd:C038091
Drug	3-dinitrobenzene	SPTBN4 WNT5B LSR BAK1 BAX BIRC2 SARDH	5.02e-05	388	57	7	ctd:C017906
Drug	Furosemide	MSR1 BAK1 BAX BIRC2 BIRC6	5.64e-05	164	57	5	ctd:D005665
Drug	AC1L1KC5	CACNB1 CACNB2 CACNG8 BAX BIRC2 BIRC3 CACNA1I TG	5.73e-05	541	57	8	CID000005428
Drug	AVPW	BIRC2 BIRC3	6.13e-05	5	57	2	CID009549245
Drug	Organogold Compounds	BAK1 BAX	6.13e-05	5	57	2	ctd:D050607
Drug	cyclohexane	LSR SLC20A1 MIB1 BAX BIRC3	6.69e-05	170	57	5	CID000008078
Drug	DMU-212	BAK1 BAX BIRC2 BIRC3	7.68e-05	90	57	4	ctd:C521792
Drug	1-alpha-25-dihydroxycholecalciferol	TINAGL1 MSR1 SSC4D SLC20A1 NTRK1 SEMA3B MIB1 BAX BIRC2 BIRC3	7.69e-05	909	57	10	CID000002524
Drug	CNS 1145	CACNB1 CACNB2 CACNA1I	7.70e-05	33	57	3	CID000190902
Drug	4-Aminopyridine	BAX BIRC2 BIRC3	7.70e-05	33	57	3	ctd:D015761
Drug	IHC-64	CACNB1 CACNB2 CACNA1I	7.70e-05	33	57	3	CID000162753
Drug	AC1L4MJU	MIB1 BAK1 BAX BIRC2 BIRC3 BIRC6	8.21e-05	288	57	6	CID000159822
Drug	AC1NUZ8M	CACNB1 CACNB2 CACNG8 CACNA1I	8.37e-05	92	57	4	CID000073211
Drug	dideoxypetrosynol A	BAX BIRC2	9.18e-05	6	57	2	ctd:C499970
Drug	Epothilones	BAX BIRC3	9.18e-05	6	57	2	ctd:D034261
Drug	NSC-725021	BIRC2 BIRC3	9.18e-05	6	57	2	CID000406741
Drug	tephrosin	BIRC2 BIRC3	9.18e-05	6	57	2	ctd:C480848
Drug	kamebakaurin	BIRC2 BIRC3	9.18e-05	6	57	2	ctd:C047382
Drug	Magnesium Sulfate	CACNB1 CACNB2	9.18e-05	6	57	2	DB00653
Drug	manidipine	CACNB1 CACNB2 CACNG8 CACNA1I	9.48e-05	95	57	4	CID000004008
Drug	isotetrandrine	CACNB1 CACNB2 BAX CACNA1I	1.03e-04	97	57	4	CID000005422
Drug	Dichlorodiphenyl Dichloroethylene	CACNB1 NTRK1 BAK1 BAX CACNA1I TG	1.07e-04	302	57	6	ctd:D003633
Drug	nitrendipine	CACNB1 CACNB2 CACNG8 CACNA1I	1.07e-04	98	57	4	CID000004507
Drug	bendamustine	BIRC2 BIRC3 BIRC6	1.09e-04	37	57	3	CID000065628
Drug	Methiothepin maleate [19728-88-2]; Up 200; 8.4uM; MCF7; HT_HG-U133A	MSR1 SEMA3B BIRC3 CACNA1I PMEL	1.10e-04	189	57	5	5413_UP
Drug	isradipine	CACNB1 CACNB2 CACNG8 CACNA1I	1.16e-04	100	57	4	CID000003784
Drug	5707885; Down 200; 50uM; PC3; HT_HG-U133A	FKRP SEMA3B PXN BAX PLXNB1	1.16e-04	191	57	5	6390_DN
Drug	NSC759576	CACNB1 CACNB2 CACNG8 CACNA1I BIRC6	1.16e-04	191	57	5	CID000003075
Drug	dihydropyridine	CACNB1 CACNB2 CACNG8 CACNA1I REM2	1.22e-04	193	57	5	CID000104822
Drug	Pentolinium bitartrate [52-62-0]; Up 200; 7.4uM; PC3; HT_HG-U133A	SPTBN4 WNT5B CACNA1I SARDH SH3D21	1.25e-04	194	57	5	3676_UP
Drug	Norgestrel-(-)-D [797-63-7]; Up 200; 12.8uM; PC3; HT_HG-U133A	WNT5B CACNB1 CACNA1I ADGRD2 CD163	1.25e-04	194	57	5	4269_UP
Drug	4-methylthioamphetamine	BAK1 BAX	1.28e-04	7	57	2	ctd:C078956
Drug	hydroxygenkwanin	BAK1 BAX	1.28e-04	7	57	2	ctd:C051414
Drug	Aklavin hydrochloride	BIRC2 BIRC3	1.28e-04	7	57	2	CID000002074
Drug	Fluorometholone [426-13-1]; Up 200; 10.6uM; PC3; HT_HG-U133A	CACNB1 IQCC FKRP CACNA1I SH3D21	1.31e-04	196	57	5	5771_UP
Drug	Pempidine tartrate [546-48-5]; Up 200; 13uM; PC3; HT_HG-U133A	CACNB1 CACNB2 IQCC PXN TG	1.31e-04	196	57	5	4307_UP
Drug	Glycocholic acid [475-31-0]; Up 200; 8.6uM; MCF7; HT_HG-U133A	CACNB1 IQCC FKRP CACNA1I FAM131A	1.31e-04	196	57	5	3315_UP
Drug	Ald1.1-H_000455; Down 200; 10uM; PC3; HT_HG-U133A	TINAGL1 IQCC PXN BIRC3 PLXNB1	1.31e-04	196	57	5	7520_DN
Drug	Riluzole hydrochloride; Up 200; 14.8uM; PC3; HT_HG-U133A	CACNB1 STARD8 CACNA1I SH3D21 CAPN10	1.34e-04	197	57	5	3666_UP
Drug	Furosemide [54-31-9]; Down 200; 12uM; PC3; HT_HG-U133A	CACNB1 BAX CACNA1I PLXNB1 CAPN10	1.34e-04	197	57	5	4503_DN
Drug	Sulfamethazine sodium salt [1981-58-4]; Up 200; 13.4uM; MCF7; HT_HG-U133A	CACNB1 BAX BIRC3 CACNA1I PMEL	1.34e-04	197	57	5	3940_UP
Drug	Isoflurane	BAK1 BAX BIRC3 CACNA1I	1.35e-04	104	57	4	ctd:D007530
Drug	Talampicillin hydrochloride [39878-70-1]; Up 200; 7.8uM; MCF7; HT_HG-U133A	CACNB1 IQCC PXN CACNA1I FAM131A	1.37e-04	198	57	5	3515_UP
Drug	Flunixin meglumine [42461-84-7]; Up 200; 8.2uM; PC3; HT_HG-U133A	CACNB1 NTRK1 PXN CACNA1I ADGRD2	1.37e-04	198	57	5	4273_UP
Drug	Iodixanol [92339-11-2]; Up 200; 2.6uM; HL60; HT_HG-U133A	NTRK1 PEX6 CACNA1I SH3D21 PLXNB1	1.37e-04	198	57	5	3023_UP
Drug	11-deoxy-16,16-dimethyl Prostaglandin E2; Down 200; 10uM; PC3; HT_HG-U133A	TINAGL1 IQCC BAX BIRC3 PLXNB1	1.37e-04	198	57	5	7519_DN
Drug	SB216763	WNT5B WNT9A SEMA3B	1.38e-04	40	57	3	CID000176158
Drug	loperamide	CACNB1 CACNB2 CACNG8 CACNA1I	1.40e-04	105	57	4	CID000003954
Drug	Imidurea [39236-46-9]; Up 200; 10.4uM; MCF7; HT_HG-U133A	MSR1 CACNB2 SEMA3B PMEL SARDH	1.40e-04	199	57	5	5481_UP
Drug	Palmatine chloride [3486-67-7]; Up 200; 10.4uM; MCF7; HT_HG-U133A	MSR1 CACNB2 STARD8 CACNA1I ADGRD2	1.40e-04	199	57	5	4957_UP
Drug	pyraclofos	CACNB1 CACNB2 CACNG8 CACNA1I	1.45e-04	106	57	4	CID000093460
Drug	TE 5	LSR BAX BIRC2	1.48e-04	41	57	3	CID003083341
Drug	K3-3	BAX TG	1.71e-04	8	57	2	CID000281832
Drug	gastrin 17	BIRC2 BIRC3	1.71e-04	8	57	2	ctd:C013550
Drug	euthroid	NTRK1 TG	1.71e-04	8	57	2	CID000071371
Drug	Trypsin Inhibitors	BAK1 BAX	1.71e-04	8	57	2	ctd:D014361
Drug	navitoclax	BAK1 BAX	1.71e-04	8	57	2	ctd:C528561
Drug	1L-6-hydroxymethyl-chiro-inositol 2(R)-2-O-methyl-3-O-octadecylcarbonate	BIRC2 BIRC3	1.71e-04	8	57	2	ctd:C477931
Drug	Epi Lovastatin	MSR1 LSR SSC4D SLC20A1 BAX CAPN10	2.06e-04	341	57	6	CID000003962
Drug	M50054	MIB1 BAX BIRC2 BIRC3	2.12e-04	117	57	4	CID002748618
Drug	N-methyl-DL-aspartic acid	CACNB1 CACNB2 CACNG8 NTRK1 BAX BIRC2 BIRC3 CACNA1I	2.14e-04	655	57	8	CID000004376
Drug	Nimodipine	CACNB1 CACNB2	2.19e-04	9	57	2	DB00393
Drug	UMI-77	BAK1 BAX	2.19e-04	9	57	2	ctd:C000592878
Drug	AC1L1KZZ	BAX BIRC2 BIRC3	2.23e-04	47	57	3	CID000005725
Drug	zerumbone	BAX BIRC2 BIRC3	2.38e-04	48	57	3	ctd:C403304
Drug	1oz0	MSR1 BAX CD163	2.53e-04	49	57	3	CID006323417
Drug	methyl antcinate A	BAK1 BAX	2.74e-04	10	57	2	ctd:C553655
Drug	tetronic acid	BIRC2 BIRC3	2.74e-04	10	57	2	CID000521261
Drug	SN50 peptide	BAX BIRC2 BIRC3	2.84e-04	51	57	3	ctd:C118258
Disease	intermittent claudication (biomarker_via_orthology)	BAK1 BAX	5.67e-05	6	58	2	DOID:3669 (biomarker_via_orthology)
Disease	ataxia telangiectasia (is_implicated_in)	BAK1 BAX	7.92e-05	7	58	2	DOID:12704 (is_implicated_in)
Disease	Sclerocystic Ovaries	SPTBN4 IQCC BAX ADGRD2	1.88e-04	144	58	4	C1136382
Disease	Polycystic Ovary Syndrome	SPTBN4 IQCC BAX ADGRD2	1.88e-04	144	58	4	C0032460
Disease	cervical squamous cell carcinoma (is_marker_for)	BAX BIRC2	8.55e-04	22	58	2	DOID:3744 (is_marker_for)
Disease	Sarcosine measurement	PEX6 SARDH	9.36e-04	23	58	2	EFO_0021668
Disease	HIV Coinfection	BAX BIRC2 BIRC3	1.11e-03	103	58	3	C4505456
Disease	HIV Infections	BAX BIRC2 BIRC3	1.11e-03	103	58	3	C0019693
Disease	glaucoma (biomarker_via_orthology)	NTRK1 BAX	1.39e-03	28	58	2	DOID:1686 (biomarker_via_orthology)
Disease	leiomyoma (is_marker_for)	WNT5B BAK1	1.39e-03	28	58	2	DOID:127 (is_marker_for)
Disease	renal cell carcinoma (is_marker_for)	BAK1 BIRC2 BIRC3	2.07e-03	128	58	3	DOID:4450 (is_marker_for)
Disease	Colonic Neoplasms	SH3KBP1 BAK1 BAX	3.36e-03	152	58	3	C0009375
Disease	Malignant tumor of colon	SH3KBP1 BAK1 BAX	3.81e-03	159	58	3	C0007102
Disease	Neuroblastoma	NTRK1 SEMA3B	3.88e-03	47	58	2	C0027819

Protein segments in the cluster

Peptide	Gene	Start	Entry
LLVQLCGGERWWGQF	BIRC6	2081	Q9NR09
NNDWWIGRLVKEGCE	CACNB1	141	Q02641
CIARWIAQRGGWVAA	BAK1	166	Q16611
DGGLRCWESGDDPWV	BIRC3	296	Q13489
GRRCWQGLWREGGEG	CAPN10	266	Q9HC96
NDWWIGRLVKEGCEI	CACNB2	156	Q08289
KAGCTGEEQWRGRPW	IQCC	446	Q4KMZ1
EGEDGWWTVERNGQR	PSTPIP1	391	O43586
LRWLQRWEEEGLGGV	NTRK1	156	P04629
AGARLVCGWLADQGW	SLC16A11	291	Q8NCK7
RWGLICGDDWGTLEA	LOXL3	441	P58215
EWIICTDWDVGFREG	NCBP2L	106	A6PVI3
HIGEDRCRTWLGEWL	LETMD1	316	Q6P1Q0
LDWCNAGWLLEGSVR	HAPLN2	191	Q9GZV7
GELGEDGWIRVQWDT	HERC2	1896	O95714
RSECSRGQGPEQWLW	PLXNB1	511	O43157
CLRGLGLFQGEWVWV	PEX6	211	Q13608
VDWQWEDQDGGNGRR	MIB1	161	Q86YT6
WGTICDDRWEVRVGQ	MSR1	371	P21757
LEQRADGERCWAAGW	PXN	281	P49023
DGERCWAAGWPRDGG	PXN	286	P49023
RWNEERGLWCEKGVQ	CACNG8	6	Q8WXS5
ERLLGWIQDQGGWDG	BAX	146	Q07812
DGAVWLCGDVWRETR	CACNA1I	616	Q9P0X4
FLWQREGPGGRWTCQ	FAM131A	11	Q6UXB0
LDWGGPRREWFELIC	AREL1	501	O15033
AEWIARCQNWEGGIG	FNTB	226	P49356
GGWGLWGVQESRRLC	INSC	16	Q1MX18
WLCVVGGWDGSRRLA	KLHDC9	91	Q8NEP7
LVSWEGGRLEWFGCN	FKRP	276	Q9H9S5
SGRIEICVSDWWGAR	FBXO27	181	Q8NI29
VRFQGEWGTICDDGW	CD163	281	Q86VB7
GICVGLWVWGRRVIQ	SLC20A1	571	Q8WUM9
WDQEPAREQAGGGWR	LSR	471	Q86X29
VIRDEWGNQIWICPG	TAF3	856	Q5VWG9
QQQGCRGGRLDGAWW	TINAGL1	266	Q9GZM7
DKGWWEGECQGRRGV	SH3D21	101	A4FU49
EVNGSERGTCLWRPW	RIPPLY1	46	Q0D2K3
KEDGGWWEGQINGRR	SH3KBP1	31	Q96B97
CIDVGWWEGELNGRR	SH3KBP1	301	Q96B97
LEVWHGGRWGTVCDD	SSC5D	211	A1L4H1
GGRWGTVCDDGWDLR	SSC5D	216	A1L4H1
RLEVWHGGRWGSVCD	SSC5D	316	A1L4H1
GRWGTVCDDNWDLRD	SSC5D	791	A1L4H1
EWTEAQRLDCWRGGQ	PMEL	51	P40967
RLADWQPGRRWGCEG	STARD8	246	Q92502
GCVFQERHGWERPGW	SARDH	496	Q9UL12
LQDWCRWMGVNARRG	PNMA6A	6	P0CW24
GGLRCWESGDDPWVE	BIRC2	311	Q13490
RDQWGGEDWELLDRV	B4GALNT4	986	Q76KP1
VCATWEQRGGRWALF	ADGRD2	211	Q7Z7M1
GWGWNDVICETRRNS	CLEC6A	186	Q6EIG7
GQRWGTVCDDAWDLR	SSC4D	491	Q8WTU2
VEWREECNWAGKDIG	SEMA3B	96	Q13214
DLPRDWLWGGCGDNV	WNT5B	151	Q9H1J7
REGCGIWDIDKAWGE	SPTBN4	391	Q9H254
SLWGCPAERWGRGDR	SCART1	861	Q4G0T1
WEQGDAGGWLRDHCL	REM2	171	Q8IYK8
GSQRRLWRWCGSEEV	SLAMF9	16	Q96A28
PREALQRLWDLCGGW	ZNF496	56	Q96IT1
QRLWDLCGGWLRPER	ZNF496	61	Q96IT1
DLENREAWQWGGCGD	WNT9A	156	O14904
AWRQAAGWLCRETGA	nan	36	Q8N6K4
AFCVDGEGRRLPWWE	TG	1541	P01266
IWIRRAGGRCLWRDD	TGM6	471	O95932
RDWLGKGWRLGSCEA	nan	6	Q6ZVH6
PEEGILEAWGSCGRW	nan	76	A6NHS1
GWNIDILERGEVRLW	MYOM3	1011	Q5VTT5
RDPWGNWCDAKDLEG	MYSM1	506	Q5VVJ2