Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyCellularComponentmicrofibril

ADAMTS10 FBN1

2.35e-0413372GO:0001527
GeneOntologyCellularComponentcytoplasmic vesicle membrane

ARFGEF3 SLC46A2 UNC13C SLC30A5 ALDH3B1 GGA1 ARCN1 STAB1 HLA-F

3.58e-041307379GO:0030659
GeneOntologyCellularComponentvesicle membrane

ARFGEF3 SLC46A2 UNC13C SLC30A5 ALDH3B1 GGA1 ARCN1 STAB1 HLA-F

3.96e-041325379GO:0012506
HumanPhenoBroad metacarpals

ADAMTS10 FBN1 EXTL3

1.95e-0519153HP:0001230
HumanPhenoBroad skull

ADAMTS10 FBN1

2.42e-053152HP:0002682
HumanPhenoMicrospherophakia

ADAMTS10 FBN1

4.84e-054152HP:0030961
HumanPhenoBrachycephaly

ADAMTS10 CHD6 ARID1B FBN1 MBD5 TBX2

4.85e-05253156HP:0000248
HumanPhenoAbnormal nasal tip morphology

TCF4 ARID1B FBN1 EXTL3 MBD5 HECW2 TBX2

5.13e-05386157HP:0000436
HumanPhenoSpherophakia

ADAMTS10 FBN1

8.05e-055152HP:0034375
HumanPhenoAbnormality of mouth size

TCF4 CHD6 ARID1B FBN1 EXTL3 MBD5 HECW2

9.55e-05425157HP:0011337
HumanPhenoNarrow foot

TCF4 FBN1

1.21e-046152HP:0001786
HumanPhenoMyopia

ADAMTS10 TCF4 CHD6 ARID1B FBN1 MBD5 ARCN1

1.32e-04447157HP:0000545
HumanPhenoScaphocephaly

FBN1 EXTL3 ARCN1

1.91e-0440153HP:0030799
HumanPhenoNarrow palate

ADAMTS10 CHD6 FBN1 HECW2 TBX2

2.02e-04202155HP:0000189
HumanPhenoSpinal canal stenosis

ADAMTS10 FBN1 EXTL3

2.38e-0443153HP:0003416
HumanPhenoAstigmatism

TCF4 ARID1B FBN1 MBD5 ARCN1

2.83e-04217155HP:0000483
HumanPhenoInflammatory abnormality of the eye

TCF4 CHD6 FBN1 EXTL3 GSN

3.02e-04220155HP:0100533
HumanPhenoAbnormal midface morphology

ADAMTS10 TCF4 CHD6 ARID1B FBN1 EXTL3 MBD5 HECW2

3.35e-04704158HP:0000309
HumanPhenoAplasia/hypoplasia involving bones of the hand

ADAMTS10 TCF4 CHD6 ARID1B FBN1 EXTL3 MBD5

4.25e-04538157HP:0005927
DomainPLAC

ADAMTS16 ADAMTS10 ADAMTS6

2.78e-0614383PF08686
DomainPLAC

ADAMTS16 ADAMTS10 ADAMTS6

7.36e-0619383IPR010909
DomainPLAC

ADAMTS16 ADAMTS10 ADAMTS6

7.36e-0619383PS50900
DomainADAM_spacer1

ADAMTS16 ADAMTS10 ADAMTS6

1.34e-0523383IPR010294
DomainADAM_spacer1

ADAMTS16 ADAMTS10 ADAMTS6

1.34e-0523383PF05986
DomainPeptidase_M12B_ADAM-TS

ADAMTS16 ADAMTS10 ADAMTS6

1.53e-0524383IPR013273
DomainPeptidase_M12B_N

ADAMTS16 ADAMTS10 ADAMTS6

6.75e-0539383IPR002870
DomainPep_M12B_propep

ADAMTS16 ADAMTS10 ADAMTS6

6.75e-0539383PF01562
DomainDISINTEGRIN_1

ADAMTS16 ADAMTS10 ADAMTS6

7.29e-0540383PS00427
DomainADAM_MEPRO

ADAMTS16 ADAMTS10 ADAMTS6

7.29e-0540383PS50215
DomainDISINTEGRIN_2

ADAMTS16 ADAMTS10 ADAMTS6

7.29e-0540383PS50214
DomainReprolysin

ADAMTS16 ADAMTS10 ADAMTS6

7.29e-0540383PF01421
DomainPeptidase_M12B

ADAMTS16 ADAMTS10 ADAMTS6

7.29e-0540383IPR001590
DomainDisintegrin_dom

ADAMTS16 ADAMTS10 ADAMTS6

7.85e-0541383IPR001762
DomainTSP_1

ADAMTS16 ADAMTS10 ADAMTS6

2.84e-0463383PF00090
DomainTSP1

ADAMTS16 ADAMTS10 ADAMTS6

3.11e-0465383SM00209
DomainTSP1_rpt

ADAMTS16 ADAMTS10 ADAMTS6

3.11e-0465383IPR000884
DomainTSP1

ADAMTS16 ADAMTS10 ADAMTS6

3.11e-0465383PS50092
DomainMetalloPept_cat_dom

ADAMTS16 ADAMTS10 ADAMTS6

5.94e-0481383IPR024079
Domain-

ADAMTS16 ADAMTS10 ADAMTS6

5.94e-04813833.40.390.10
DomainZINC_PROTEASE

ADAMTS16 ADAMTS10 ADAMTS6

1.03e-0398383PS00142
DomainHECT

HERC3 HECW2

1.37e-0327382PF00632
DomainHECTc

HERC3 HECW2

1.37e-0327382SM00119
DomainHECT_dom

HERC3 HECW2

1.37e-0327382IPR000569
DomainHECT

HERC3 HECW2

1.37e-0327382PS50237
DomainGrowth_fac_rcpt_

FBN1 IGFBP2 STAB1

3.89e-03156383IPR009030
Domain-

SARDH GSR

5.79e-03563823.50.50.60
DomainFAD/NAD-binding_dom

SARDH GSR

6.00e-0357382IPR023753
PathwayREACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS

ADAMTS16 ADAMTS10 ADAMTS6

7.55e-0539303M27417
PathwayREACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS

ADAMTS16 ADAMTS10 ADAMTS6

7.55e-0539303MM15165
PathwayPID_AR_PATHWAY

NCOA2 TCF4 GSN

2.88e-0461303M58
PathwayREACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS

ADAMTS16 ADAMTS10 ADAMTS6

3.97e-0468303M27303
Pubmed

Proteolysis of fibrillin-2 microfibrils is essential for normal skeletal development.

ADAMTS10 FBN1 ADAMTS6

9.71e-071838335503090
Pubmed

Disruption of the ARID1B and ADAMTS6 loci due to a t(5;6)(q12.3;q25.3) in a patient with developmental delay.

ARID1B ADAMTS6

1.16e-06238225250687
Pubmed

ADAMTS10 protein interacts with fibrillin-1 and promotes its deposition in extracellular matrix of cultured fibroblasts.

ADAMTS10 FBN1

1.16e-06238221402694
Pubmed

ADAMTS-10 and -6 differentially regulate cell-cell junctions and focal adhesions.

ADAMTS10 ADAMTS6

1.16e-06238227779234
Pubmed

Adamts10 inactivation in mice leads to persistence of ocular microfibrils subsequent to reduced fibrillin-2 cleavage.

ADAMTS10 FBN1

3.48e-06338230201140
Pubmed

Stabilin-1 localizes to endosomes and the trans-Golgi network in human macrophages and interacts with GGA adaptors.

GGA1 STAB1

6.96e-06438215345724
Pubmed

Weill-Marchesani Syndrome

ADAMTS10 FBN1

6.96e-06438220301293
Pubmed

An integrative systems approach identifies novel candidates in Marfan syndrome-related pathophysiology.

FBN1 IGFBP2

6.96e-06438230677223
Pubmed

Metalloproteinase Adamts16 Is Required for Proper Closure of the Optic Fissure.

ADAMTS16 ADAMTS6

1.16e-05538229625437
Pubmed

The chromatin remodeler CHD6 promotes colorectal cancer development by regulating TMEM65-mediated mitochondrial dynamics via EGF and Wnt signaling.

TCF4 CHD6

1.16e-05538236473865
Pubmed

PCR isolation and cloning of novel splice variant mRNAs from known drug target genes.

ALDH3B1 HTR3A FOLR2

3.20e-055638315028279
Pubmed

ADAMTS: a novel family of extracellular matrix proteases.

ADAMTS10 ADAMTS6

5.20e-051038211167130
Pubmed

O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.

ADAMTS16 ADAMTS10 ADAMTS6

7.70e-057538320637190
Pubmed

TIF1gamma controls erythroid cell fate by regulating transcription elongation.

TCF4 SSBP2

1.76e-041838220603019
Pubmed

Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.

ADAMTS16 ARFGEF3 SLC30A5 GGA1 ARCN1 OTUD7B

1.83e-0477738635844135
Pubmed

ETO2 coordinates cellular proliferation and differentiation during erythropoiesis.

TCF4 SSBP2

2.18e-042038216407974
Pubmed

Biological insights from 108 schizophrenia-associated genetic loci.

TCF4 GFOD2 OTUD7B STAB1

3.30e-0430338425056061
Pubmed

Mouse screen reveals multiple new genes underlying mouse and human hearing loss.

TCF4 ARID1B ALDH3B1 AKAP9 HECW2 OTUD7B HLA-F

3.48e-04124238730973865
Pubmed

Control of developmentally primed erythroid genes by combinatorial co-repressor actions.

TCF4 SSBP2

4.96e-043038226593974
Pubmed

Disruption of SoxB1-dependent Sonic hedgehog expression in the hypothalamus causes septo-optic dysplasia.

TCF4 TBX2

5.30e-043138222421044
Pubmed

TBX1 is required for normal stria vascularis and semicircular canal development.

FBN1 STAB1

5.30e-043138231550482
Pubmed

Interaction network of human early embryonic transcription factors.

NCOA2 SSBP2 ARID1B TBX2

5.74e-0435138438297188
Pubmed

Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.

NHSL1 CHD6 HECW2

6.29e-0415338310718198
Pubmed

The recombinant congenic strains--a novel genetic tool applied to the study of colon tumor development in the mouse.

GSR HLA-F

6.38e-04343821686571
Pubmed

Gene content of the 750-kb critical region for mouse embryonic ectoderm lethal tcl-w5.

ADAMTS10 HLA-F

7.15e-043638215112104
Pubmed

Cardiac-specific developmental and epigenetic functions of Jarid2 during embryonic development.

IGFBP2 TBX2

7.15e-043638229891551
Pubmed

Adamts18 Deficiency Causes Spontaneous SMG Fibrogenesis in Adult Mice.

ADAMTS16 FBN1

7.56e-043738234323105
Pubmed

High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men.

NCOA2 TCF4 IGFBP2 TBX2

7.95e-0438338419453261
Pubmed

Genetic composition of the recombinant congenic strains.

GSR HLA-F

9.28e-04413828903730
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

ARFGEF3 CHD6 HERC3 AKAP9

9.96e-0440738412693553
Pubmed

The Dual Estrogen Receptor α Inhibitory Effects of the Tissue-Selective Estrogen Complex for Endometrial and Breast Safety.

NCOA2 CHD6

1.02e-034338226487511
Pubmed

The Evf2 Ultraconserved Enhancer lncRNA Functionally and Spatially Organizes Megabase Distant Genes in the Developing Forebrain.

SSBP2 HTR3A

1.07e-034438230146317
Cytoband6q23.3

ARFGEF3 NHSL1

2.49e-04283826q23.3
GeneFamilyADAM metallopeptidases with thrombospondin type 1 motif

ADAMTS16 ADAMTS10 ADAMTS6

2.23e-061925350
GeneFamilyBasic helix-loop-helix proteins

NCOA2 TCF4

1.00e-02110252420
GeneFamilySolute carriers

SLC46A2 SLC30A5 SLC12A9

1.67e-02395253752
GeneFamilyArmadillo repeat containing|Protein phosphatase 1 regulatory subunits

ARFGEF3 AKAP9

2.57e-02181252694
CoexpressionAtlasFacebaseRNAseq_ratio_e10.5_MaxillaryArch_vs_Mandibular_top-relative-expression-ranked_1000_k-means-cluster#2

TCF4 FBN1 HECW2 GSN TBX2

3.94e-06134385Facebase_RNAseq_ratio_e10.5_MaxillaryArch_vs_Mandibular_1000_K2
CoexpressionAtlasfacebase_RNAseq_e14.5_palate_poster_distal_ERK2_WT_2500_K1

ADAMTS16 ADAMTS10 ARFGEF3 TCF4 SSBP2 DEPDC1 FBN1 MBD5 ADAMTS6 STAB1

2.76e-0511663810facebase_RNAseq_e14.5_palate_poster_distal_ERK2_WT_2500_K1
ToppCellrenal_papilla_nuclei-Adult_normal_reference|renal_papilla_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group

TCF4 UNC13C SSBP2 IGFBP2 TBX2

6.01e-071923856c106b91e46eabbe686a52a65a9c94ad9cbe9390
ToppCellParenchyma_COVID-19|World / Sample group, Lineage and Cell type

ADAMTS16 TCF4 ARID1B FBN1 STAB1

7.00e-0719838545ab554e6d0399b3182f089a25b2adf96de1144b
ToppCellCOPD-Myeloid-Macrophage|Myeloid / Disease state, Lineage and Cell class

NHSL1 TCF4 SSBP2 FOLR2 STAB1

7.18e-071993851cf1b2d6debf9e3389f1829dcaa2857e9533a080
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TCF4 ADAMTS6 HECW2 GSN STAB1

7.36e-072003852e47888e041ec3d265425d1df97b6665c6da889c
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TCF4 ADAMTS6 HECW2 GSN STAB1

7.36e-0720038550fa0f8a3e490d5941b34e66a10158eba6c909d4
ToppCellfacs-Marrow-Granulocytes-24m|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IGFBP2 ALDH3B1 GSN GSR

1.28e-05169384ee1969755180df58d32904e2bb4192da9373d03e
ToppCellClub-club-1|World / Class top

BRME1 SLC46A2 SARDH

1.34e-055438348f80b20b1c4995a0f7084d31666781dce4009a9
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ADAMTS16 UNC13C IGFBP2 ADAMTS6

1.61e-051793848766a5a066091879f521acfc612abf563ff78808
ToppCell10x5'-lymph-node_spleen-Myeloid_Mac-Cycling_Myeloid-Mac|lymph-node_spleen / Manually curated celltypes from each tissue

DEPDC1 FOLR2 GSN STAB1

1.64e-051803844eea8366cdb82c356325ce88f09ad8b302c17a07
ToppCell3'_v3-lymph-node_spleen-Lymphocytic_Invariant-Inducer-like-ILC3|lymph-node_spleen / Manually curated celltypes from each tissue

ARFGEF3 UNC13C SSBP2 GSN

1.79e-05184384479e60f76c191253e23699c9dd7ef7efc08c59ad
ToppCellMild-NK|World / Disease group and Cell class

ADAMTS10 TCF4 SSBP2 GSN

1.83e-051853840565b7c464e1a09e596f5a0b363d2dc9b55c3c50
ToppCelldroplet-Liver-Hepatocytes-18m-Endothelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NCOA2 HECW2 TBX2 STAB1

1.87e-0518638437860daeecd6d412bd3797f30496a56da667fbd1
ToppCelldroplet-Liver-Hepatocytes-18m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NCOA2 HECW2 TBX2 STAB1

1.87e-0518638460830822d3de3147816693404fd03392e04c2b8e
ToppCelldroplet-Liver-Hepatocytes-18m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NCOA2 HECW2 TBX2 STAB1

1.87e-05186384baebeffdd426ce767190ddefc857cc78e6a58d36
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_Arw_fibro_(16)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

SSBP2 FBN1 ADAMTS6 GSN

1.91e-051873845258674d0346e5c51a4b965efcdc1790c970845d
ToppCellTCGA-Breast-Primary_Tumor-Breast_Carcinoma-Infiltrating_Ductal_Carcinoma-6|TCGA-Breast / Sample_Type by Project: Shred V9

ADAMTS16 TCF4 FBN1 ADAMTS6

1.91e-05187384a96495803ba13fcfadd1d83b3cf5774f3fed0a20
ToppCellMesenchymal-myofibroblast_cell|World / Lineage, Cell type, age group and donor

TCF4 UNC13C FBN1 TBX2

1.99e-0518938444e37f88137bb249933eb615235b2cf2ae7f3925
ToppCellrenal_medulla_nuclei|World / Celltypes from Cells and Nuclei per compartment and clinical group

NCOA2 SSBP2 ARID1B MBD5

1.99e-05189384830d9cd0dd706bce22eb2416f07b2c31c870a05a
ToppCellLV-01._Fibroblast_I|World / Chamber and Cluster_Paper

TCF4 SSBP2 FBN1 GSN

2.03e-0519038412992ec80a7b4f4f17de693f0719ee061a9918fd
ToppCellPCW_13-14|World / Celltypes from embryonic and fetal-stage human lung

TCF4 UNC13C MBD5 TBX2

2.03e-0519038462a3ec1ae0829602b0569cc051210551644f1d46
ToppCellB_cell_maturation-CD34+_pre-plamsa|B_cell_maturation / Lineage and Cell class

TCF4 SSBP2 SARDH GSN

2.08e-051913844ee160a863d4fb9c4c9449633b9f337db8871992
ToppCellLV-02._Fibroblast_II|World / Chamber and Cluster_Paper

TCF4 SSBP2 FBN1 GSN

2.08e-05191384d36565257ccba8c1bbed2c1c01be66a9cbb5f834
ToppCellhuman_hepatoblastoma-Tumor_cells|World / Sample and Cell Type and Tumor Cluster (all cells)

CHD6 ARID1B AKAP9 MBD5

2.12e-05192384916fbec1c7ab7969bda711886ac88e877e30c280
ToppCellRV-01._Fibroblast_I|RV / Chamber and Cluster_Paper

TCF4 SSBP2 FBN1 GSN

2.12e-05192384356160b113c3305a61ceeaff33ce3c9da0be2878
ToppCellLPS-antiTNF-Endothelial-Endothelial-Gen_Cap|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TCF4 IGFBP2 ADAMTS6 HECW2

2.16e-051933846e1982d089a9de628e6006d23ff78a223fbd9f47
ToppCellLAM-Myeloid-DC|Myeloid / Condition, Lineage and Cell class

TCF4 FOLR2 GSN STAB1

2.16e-05193384f665cce40053ae5d6e28f9f70ddf78e8598c9514
ToppCellLV-01._Fibroblast_I|LV / Chamber and Cluster_Paper

TCF4 SSBP2 FBN1 GSN

2.16e-05193384dc17f3b9758936d428cf17f77a1ce6d4c479b165
ToppCellfacs-Liver-Non-hepatocytes-3m|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TCF4 HECW2 GSN STAB1

2.16e-051933848084fa0ce61f1f4a728423b6b81df04eaa5af5b6
ToppCellhuman_hepatoblastoma|World / Sample and Cell Type and Tumor Cluster (all cells)

CHD6 ARID1B AKAP9 MBD5

2.16e-05193384e6a688bc834f845ff64dae1be64f073eec5091a1
ToppCellMesenchymal-matrix_fibroblast_1_cell|World / Lineage, Cell type, age group and donor

TCF4 UNC13C FBN1 TBX2

2.16e-05193384acad568621ed677031797b8c2e34dafea798d681
ToppCellRV-02._Fibroblast_II|RV / Chamber and Cluster_Paper

TCF4 SSBP2 FBN1 GSN

2.21e-0519438411c79a8c56ece42713b04b321982e41e239f07a5
ToppCell10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell-SMC_prolif-C|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

HECW2 MICOS10 CCDC74A TBX2

2.21e-05194384b8aa48d7774e4da3351ee2177eb694fcfec7cbc3
ToppCellLPS-IL1RA-Endothelial-Endothelial-Gen_Cap|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TCF4 IGFBP2 ADAMTS6 HECW2

2.21e-051943840b9cd96fa0b616da7cc90e92ff71157e9bba518f
ToppCellSmart-seq2-bone_marrow_(Smart-seq2)-myeloid|bone_marrow_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

ALDH3B1 GSN GSR STAB1

2.25e-05195384b0dbaae86f5703ab62f925e0f36500274044884a
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

TCF4 UNC13C MBD5 TBX2

2.25e-051953840e55fa5b3cbeb7baee3d4ac272a3bf80381ec937
ToppCellRV-02._Fibroblast_II|World / Chamber and Cluster_Paper

TCF4 SSBP2 FBN1 GSN

2.25e-05195384ce90b30dcdb56d4cd925cdb79fd9d7cefd998f48
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TCF4 ADAMTS6 HECW2 GSN

2.30e-051963848f2031b1a9232c389517fbf3c29f47f9468b0077
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Endothelial|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TCF4 ADAMTS6 HECW2 GSN

2.30e-0519638448b4a9cea97a55190217deaf51bf867608c5a9a7
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TCF4 ADAMTS6 HECW2 GSN

2.30e-05196384b8f89a50114932c08fc5daac4b549adfe9df8e66
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TCF4 ADAMTS6 HECW2 GSN

2.30e-05196384473980c827443464d08a0be28c53e3536369b12a
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TCF4 ADAMTS6 HECW2 GSN

2.30e-05196384145fcf73deba9638b391a1af6c39fa205dc9829f
ToppCell390C-Myeloid-Dendritic-cDC_proliferating_1|Dendritic / Donor, Lineage, Cell class and subclass (all cells)

BRME1 DEPDC1 IGFBP2 STAB1

2.30e-0519638436ed1918f70b6f5760bb088b15ce422998055cc7
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TCF4 ADAMTS6 HECW2 GSN

2.30e-05196384d0ff1082898d2db47c88d2678466514e9e9193d3
ToppCell(6)_Macrophage|World / shred on Cell_type and subtype

ALDH3B1 FOLR2 GSN STAB1

2.34e-05197384010b275d4da4a896175ad7fbaa96d1dc11a0b744
ToppCell10x3'2.3-week_17-19-Mesenchymal_adipo|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

UNC13C FBN1 IGFBP2 TBX2

2.34e-051973845afddde4e2b5cd55abe11e9b9efae02dbdc3da3a
ToppCell10x3'2.3-week_17-19-Mesenchymal_adipo-stroma-adipo-CAR|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

UNC13C FBN1 IGFBP2 TBX2

2.34e-051973841baffd087ca194a7355fefbb3bf67befb14fe2de
ToppCellPCW_13-14-Mesenchymal|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

TCF4 UNC13C FBN1 TBX2

2.34e-0519738473a2085d2682d636726a5432d572ae2a3fbe1c3f
ToppCell10x3'2.3-week_17-19-Mesenchymal_adipo-stroma|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

UNC13C FBN1 IGFBP2 TBX2

2.34e-05197384b9745e382baa2725dfcae060701fb53f6c8a31fa
ToppCellParenchymal-NucSeq|Parenchymal / Cell types per location group and 10X technology with lineage, and cell group designations

NCOA2 NHSL1 ARID1B MBD5

2.39e-051983841996373bdccc55aac347d349bd22f6aad6d0c668
ToppCellBronchial_Biopsy|World / Tissue, Lineage and Cell class of Lung Cells from 10X

TCF4 CHD6 IGFBP2 AKAP9

2.39e-05198384f5b7013045b61fc56894f80092f799770dde1c8f
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TCF4 HECW2 GSN STAB1

2.44e-051993848b62d43af8b2ebb4c1b2d068d50beaf35728dbe7
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TCF4 HECW2 GSN STAB1

2.44e-05199384da5a88749d859d535daa030d0974485906cc0ba7
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TCF4 ADAMTS6 GSN STAB1

2.44e-05199384f35e9c05d0a0339ff691b38564da7aad8e9218aa
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Parietal_and_Temporal-6|World / Primary Cells by Cluster

ARFGEF3 UNC13C SSBP2 AKAP9

2.44e-051993841b1bccf4293f11048709d15a3c892c0edf3da3d2
ToppCellmetastatic_Brain-Fibroblasts|metastatic_Brain / Location, Cell class and cell subclass

TCF4 FBN1 IGFBP2 TBX2

2.44e-0519938463eb2106bb6e2e33d020628583536c8d96662c84
ToppCellPCW_10-12-Mesenchymal|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

TCF4 UNC13C FBN1 TBX2

2.44e-05199384a09292de4c4447b8eee55d401808e43b817321cc
ToppCellTracheal-NucSeq|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations

NCOA2 SSBP2 ARID1B MBD5

2.44e-0519938494b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Parietal_and_Temporal|World / Primary Cells by Cluster

ARFGEF3 UNC13C SSBP2 AKAP9

2.44e-051993844bee94c116c0da5eba951cb4cea7cc9dcdd6e30f
ToppCellILEUM-non-inflamed-(7)_Endothelial_cell-(7)_CD36+_endothelial_cells|(7)_Endothelial_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

IGFBP2 HECW2 GSN HLA-F

2.48e-0520038446dac23d8f9d426fe52ad6dac9c15ce91e615762
ToppCellIIH-mono1-|IIH / Condition, Cell_class and T cell subcluster

TCF4 FOLR2 GSN STAB1

2.48e-05200384555207143ecc89cdd55c30a513b31cf5dfd26dbc
ToppCellLung_Parenchyma-Severe|Lung_Parenchyma / Location, Disease Group, Cell group, Cell class (2021.03.09)

TCF4 IGFBP2 FOLR2 STAB1

2.48e-0520038462502bb23ca732daed32c838ce9719093f3aaeb0
ToppCellSigmoid-(6)_Macrophage-(61)_LYVE1_Macrophage|Sigmoid / shred on region, Cell_type, and subtype

ALDH3B1 FOLR2 GSN STAB1

2.48e-05200384bc0280d52e4edc2c5edf4ead164a1c7cf3fccd60
ToppCellkidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TCF4 ADAMTS6 HECW2 GSN

2.48e-05200384dba96cda5f3b780a3d4171b61bc8aaddc1f5d466
ToppCellSigmoid-Macrophage-LYVE1_Macrophage|Sigmoid / Region, Cell class and subclass

ALDH3B1 FOLR2 GSN STAB1

2.48e-05200384851a1b372ddbec522829069e69ed36a1f4832131
ToppCellIIH-mono1|IIH / Condition, Cell_class and T cell subcluster

TCF4 FOLR2 GSN STAB1

2.48e-0520038485c090fa714a6a02703ed38d3d49788ec0119666
ToppCellkidney_cells-Hypertensive_with+without-CKD-Endothelial|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TCF4 ADAMTS6 HECW2 GSN

2.48e-052003847a69ad5b6c84f1aebacea5cacb9bc5c63dfd1dac
ToppCellControl_saline-Endothelial-Endothelial-Vein|Control_saline / Treatment groups by lineage, cell group, cell type

UNC13C FBN1 ADAMTS6 STAB1

2.48e-05200384e5f876910bc8cb390d9b46a48d9b6d4d57235551
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Upper_Layer_Occipital|World / Primary Cells by Cluster

ARFGEF3 NHSL1 SSBP2 AKAP9

2.48e-052003846bbe8e1f3e91678f1bfb14945365c1578a59a604
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Upper_Layer_Occipital-19|World / Primary Cells by Cluster

ARFGEF3 NHSL1 SSBP2 AKAP9

2.48e-05200384c831d9e0a7178e3634da45548f91fa9e8dc6557c
ToppCell(61)_LYVE1_Macrophage|World / shred on Cell_type and subtype

ALDH3B1 FOLR2 GSN STAB1

2.79e-05206384711e961a9a03bfd2f0958bd14f25f7f207a2f2b5
ToppCellTCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma-Stomach_Adenocarcinoma_-_Tubular-3|TCGA-Stomach / Sample_Type by Project: Shred V9

UNC13C ADAMTS6 HECW2

6.84e-0593383d108fce6bc55e76ba1861ab601bffca29b85b8fa
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell_prolif|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

BRME1 TCF4 ADAMTS6

2.25e-04139383b07929348ec9ad95d7bce33a7deac0938227b19f
ToppCellIIH-CD4-CD8_1|IIH / Condition, Cell_class and T cell subcluster

BRME1 SARDH SLC12A9

2.55e-04145383296b6b0eea3233d76742ea35252b2f54d4c27ab6
ToppCellTCGA-Breast-Primary_Tumor-Breast_Carcinoma-Infiltrating_Ductal_and_Lobular_Carcinoma-6|TCGA-Breast / Sample_Type by Project: Shred V9

ADAMTS16 TCF4 FBN1

2.76e-041493833904f8ce9078de238600ceceee0116af52256a1c
ToppCellFrontal_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

TCF4 CHD6 HTR3A

3.34e-041593837f29f9dcf25ffa1822b137c571e9ac16defc6292
ToppCellBAL-Mild-cDC_5|Mild / Compartment, Disease Groups and Clusters

ADAMTS10 SLC46A2 FBN1

3.46e-041613837a6e8ed0b5d999efce8945d8083ab01d71be9a92
ToppCellcontrol-Epithelial-Ciliated-diff|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

IGFBP2 ALDH3B1 FOLR2

3.46e-04161383ef4b946914a4e2727ed57362dc6965c299520f35
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TCF4 FBN1 HECW2

3.52e-041623832ac02523348660e514d464f8f2434ee0c312d784
ToppCell368C-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

FOLR2 GSN STAB1

3.59e-041633834b8abbad4df040c895e3afb240759ebbc66b4d0e
ToppCell3'-GW_trimst-1.5-LargeIntestine-Neuronal-neuron_precursor|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ARFGEF3 IGFBP2 TBX2

3.59e-0416338399cf60dc87f7ce288553091bffcd85109a02bd8f
ToppCell3'-GW_trimst-1.5-LargeIntestine-Neuronal-neuron_precursor-Neuroblast|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ARFGEF3 IGFBP2 TBX2

3.59e-04163383510c0af66e82c5a8cf8edd0547dae4018a87dbbf
ToppCell3'_v3-Lung-Lymphocytic_B-ABC_aged-B_memory|Lung / Manually curated celltypes from each tissue

HTR3A HECW2 CCDC74A

3.65e-041643837766900740f67dbbe3c4d90fbfdcc1665cee6515
ToppCell10x5'-GI_large-bowel-Lymphocytic_T_CD8-Tem/emra_CD8|GI_large-bowel / Manually curated celltypes from each tissue

ARFGEF3 NHSL1 IGFBP2

3.78e-0416638313bef304ea3df8e8d2bc376a3287c78220a1b0c6
ToppCellDendritic_Cells-Donor_02|World / lung cells shred on cell class, cell subclass, sample id

TCF4 FOLR2 STAB1

3.78e-04166383fbeb74b98b58085de323f744b18d4a8f7b22d5d4
ToppCellDividing_Macrophages-Cryobiopsy_01|World / lung cells shred on cell class, cell subclass, sample id

DEPDC1 ADAMTS6 TBX2

3.78e-04166383c503036f3c19ef186e1e62c9643c49dea3827f51
ToppCelldroplet-Marrow-BM-1m-Hematologic-proerythroblast|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ALDH3B1 GSN GSR

3.78e-04166383758817f38e843db4ef6ab3e2bfb9f1a2075c9af9
ToppCellfacs-Marrow-T_cells-18m-Myeloid|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ALDH3B1 GSN GSR

3.78e-04166383fab4da2537904ad114218f720e18a600f14a00a1
ToppCellAdult-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D231|Adult / Lineage, Cell type, age group and donor

TCF4 HECW2 TBX2

3.85e-041673835af9127bae05768a5164d5708a4ad37edca99324
ToppCellCOVID-19-kidney-Lymphatic_EC|kidney / Disease (COVID-19 only), tissue and cell type

TCF4 FBN1 HECW2

3.85e-0416738397d0fea1f41c1c00e36d9b5c4c1f0dd85087056f
ToppCellTCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Squamous_Cell_Carcinoma-4|TCGA-Lung / Sample_Type by Project: Shred V9

ADAMTS16 FBN1 STAB1

3.92e-04168383aefea14b8b1c1b6a05f827effd22ba15274fddc9
ToppCellfacs-Marrow-Granulocytes-24m-Myeloid|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ALDH3B1 GSN GSR

3.92e-041683833611605114f6b668b44728d6563cd02389e106af
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Pygm_C1ql1|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

TCF4 FBN1 HTR3A

3.92e-04168383f3879a8e11eaf866f37c52e67021be43f0b8784a
ToppCellImmune_cells-Neutrophils|Immune_cells / Lineage and Cell class

ALDH3B1 GSN GSR

3.92e-041683833539f802fe0143da1462df0618f78f9f15143f71
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-5_RORB_CMAHP|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ADAMTS16 UNC13C ADAMTS6

3.92e-041683831d58731a481ecac84c15affa84f8041dd67d944c
ToppCellfacs-Marrow-Granulocytes-24m-Myeloid-granulocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IGFBP2 GSN GSR

3.99e-04169383f38b52972a6c492ce2fd520a26bb3fc8db23bf85
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

NHSL1 TCF4 HECW2

3.99e-04169383987ff79ad563825dd9877ea8ccb536758f8c6700
ToppCell390C-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)|390C / Donor, Lineage, Cell class and subclass (all cells)

FOLR2 GSN STAB1

3.99e-041693832c851b2703c7b8b656026f996f5fc027e4a79b36
ToppCellfacs-Marrow-Granulocytes-24m-Myeloid-granulocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IGFBP2 GSN GSR

3.99e-041693835320da1d61806b53e0bd96bbdfdb8fd69246681b
ToppCell3'_v3-Lung-Myeloid_Mac-Intestinal_macrophages|Lung / Manually curated celltypes from each tissue

TCF4 FOLR2 STAB1

3.99e-04169383241644823e6f949aaf4c671d4579721d7ef6b0e5
ToppCellfacs-Marrow-Granulocytes|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ALDH3B1 GSN GSR

4.13e-041713831701dedf0c18751db6c9fee3d93fff150ed0e17f
DiseaseWeill-Marchesani syndrome

ADAMTS10 FBN1

4.59e-063372C0265313
DiseaseWeill-Marchesani Syndrome, Autosomal Dominant

ADAMTS10 FBN1

4.59e-063372C1869115
DiseaseWeill-Marchesani Syndrome, Autosomal Recessive

ADAMTS10 FBN1

4.59e-063372C1869114
DiseaseWeill-Marchesani syndrome (implicated_via_orthology)

ADAMTS10 FBN1

4.59e-063372DOID:0050475 (implicated_via_orthology)
DiseaseWeill-Marchesani syndrome

ADAMTS10 FBN1

9.17e-064372cv:C0265313
DiseaseWeill-Marchesani syndrome (is_implicated_in)

ADAMTS10 FBN1

9.17e-064372DOID:0050475 (is_implicated_in)
DiseaseBipolar Disorder

TCF4 SSBP2 IGFBP2 HTR3A MBD5 STAB1

2.63e-05477376C0005586
DiseaseNeuroblastoma

CHD6 ARID1B TBX2

2.83e-0547373C0027819
Diseasespontaneous preterm birth

NHSL1 EXTL3 TBX2

2.78e-04101373EFO_0006917
Diseasecorneal topography

NHSL1 FBN1 ADAMTS6

3.48e-04109373EFO_0004345
Diseaseurate measurement

TCF4 HERC3 MBD5 FOLR2 STAB1 HLA-F

7.97e-04895376EFO_0004531
Diseasecortical surface area measurement

NCOA2 NHSL1 TCF4 SSBP2 ARID1B FBN1 EXTL3

1.25e-031345377EFO_0010736
Diseasepotassium measurement

TCF4 TBX2

1.46e-0345372EFO_0009283
Diseaseurinary albumin to creatinine ratio

TCF4 UNC13C STAB1

1.47e-03179373EFO_0007778
Diseasealkaline phosphatase measurement

NCOA2 UNC13C SLC30A5 SLC12A9 GFOD2 GSN

1.52e-031015376EFO_0004533

Protein segments in the cluster

PeptideGeneStartEntry
AKLIEMNGGGTGCNH

AKAP9

3496

Q99996
MNGGGTGCNHELEMI

AKAP9

3501

Q99996
TSSGGFCGNDGFMHM

ALDH3B1

381

P43353
GIHMQGLGCDEMLQG

GSR

476

P00390
MGNHCSHMGGPQDFE

HTR3A

381

P46098
DQHGGQQSPGMGMMH

ARID1B

336

Q8NFD5
CMGNSQHQGRQMGAG

CCDC74A

241

Q96AQ1
HTFGMNHDGVGNSCG

ADAMTS10

396

Q9H324
GHNFGMIHDGEGNMC

ADAMTS16

436

Q8TE57
GHNFGMNHDGIGNSC

ADAMTS6

406

Q9UKP5
MNHDGIGNSCGTKGH

ADAMTS6

411

Q9UKP5
AGSHTLQGMNGCDMG

HLA-F

111

P30511
MGAEGMEGGASGNLH

HECW2

166

Q9P2P5
MHLGTNGANCGGVES

OTUD7B

271

Q6GQQ9
FGAGSCGQLGHDSMN

HERC3

266

Q15034
CHQQSLLGGDMDMGN

TCF4

121

P15884
IAAQMGHFSGSSGNM

NHSL1

291

Q5SYE7
NHVDSTMNMLGGGGS

IGFBP2

161

P18065
MGGSCHNLIGLSNMH

DEPDC1

396

Q5TB30
MVMSHSQGGAAAGSS

GGA1

231

Q9UJY5
GESMMGAGDSGHASP

BRME1

426

Q0VDD7
MTSHNGMEDSGGGGT

CHD6

76

Q8TD26
IGQGHCVSGMGMGRG

FBN1

2681

P35555
MLRNGGAGNGGQTCM

EXTL3

6

O43909
TFCSGMMHSPGFDGN

ARFGEF3

706

Q5TH69
CDELMGGGGLHTMGT

GFOD2

166

Q3B7J2
AMHVNAGEMLHGTGG

FOLR2

226

P14207
GNCGMLSQSGMALGN

MBD5

791

Q9P267
TAMAAQHGMDDDGTG

GSN

431

P06396
CGRDGGLQNMELHGM

ARCN1

286

P48444
GSGMGLGMAYSNCQH

MICOS10

46

Q5TGZ0
GLGGMESHHMNGSLG

SSBP2

296

P81877
SAGMMLGGGCGQELA

SARDH

411

Q9UL12
FGGSGGMNHVSGMQA

NCOA2

441

Q15596
DSGMSNGMVCASGDR

UNC13C

626

Q8NB66
MGMGHLLASVAGGGN

TBX2

506

Q13207
NGCTGIMAGANMSGE

SLC12A9

276

Q9BXP2
MDGMSGSGQCLCRSG

STAB1

1986

Q9NY15
HSHGSAGGGMNANMR

SLC30A5

576

Q8TAD4
CGSMASGHLFKQMAG

SLC46A2

186

Q9BY10