Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcessmitotic cell cycle phase transition

CUL4B CUL4A CUL1 EPS8 NBN SPDL1 CCNB3 CRLF3 DYNC1LI1 PRKDC MYO16 USP47

2.53e-0550911412GO:0044772
GeneOntologyBiologicalProcesscell cycle phase transition

CUL4B CUL4A CUL1 EPS8 NBN DTX3L SPDL1 CCNB3 CRLF3 DYNC1LI1 PRKDC MYO16 USP47

4.35e-0562711413GO:0044770
GeneOntologyBiologicalProcessnegative regulation of cell cycle phase transition

CUL4A NBN DTX3L SPDL1 CRLF3 DYNC1LI1 PRKDC MYO16 USP47

5.82e-053111149GO:1901988
GeneOntologyCellularComponentruffle membrane

EPS8 SH2D3C TIAM1 NF2 SYNJ2 TLN1

2.81e-051081146GO:0032587
GeneOntologyCellularComponentleading edge membrane

EPS8 SH2D3C TIAM1 NF2 SYNJ2 TLN1 SYNE2

1.55e-042101147GO:0031256
GeneOntologyCellularComponentextrinsic component of postsynaptic membrane

AKAP9 TIAM1 FARP1

2.26e-04221143GO:0098890
GeneOntologyCellularComponentmicrotubule organizing center

NUDT21 MAPKAPK2 CCDC18 IFT46 HMMR ARHGAP35 SPDL1 TBC1D31 AKAP9 TIAM1 CCNB3 PDE4DIP DYNC1LI1 CAMSAP1

4.79e-0491911414GO:0005815
GeneOntologyCellularComponent90S preribosome

HEATR1 PES1 IMP3

5.20e-04291143GO:0030686
GeneOntologyCellularComponentcell projection membrane

EPS8 EPS15 SH2D3C IFT46 TIAM1 NF2 SYNJ2 TLN1 SYNE2

5.95e-044311149GO:0031253
GeneOntologyCellularComponentextrinsic component of synaptic membrane

AKAP9 TIAM1 FARP1

9.10e-04351143GO:0099243
GeneOntologyCellularComponentruffle

EPS8 SH2D3C TIAM1 NF2 SYNJ2 TLN1

9.39e-042061146GO:0001726
GeneOntologyCellularComponentcentrosome

NUDT21 MAPKAPK2 CCDC18 IFT46 HMMR SPDL1 TBC1D31 AKAP9 TIAM1 CCNB3 PDE4DIP DYNC1LI1

1.02e-0377011412GO:0005813
GeneOntologyCellularComponentextrinsic component of postsynaptic density membrane

AKAP9 TIAM1

1.29e-03101142GO:0099147
GeneOntologyCellularComponentGolgi transport complex

COG2 COG3

1.29e-03101142GO:0017119
DomainCullin_CS

CUL4B CUL4A CUL1

7.82e-0671153IPR016157
DomainCULLIN

CUL4B CUL4A CUL1

7.82e-0671153SM00182
DomainCullin_neddylation_domain

CUL4B CUL4A CUL1

1.25e-0581153IPR019559
DomainCullin_Nedd8

CUL4B CUL4A CUL1

1.25e-0581153PF10557
DomainCullin_Nedd8

CUL4B CUL4A CUL1

1.25e-0581153SM00884
DomainCullin_homology

CUL4B CUL4A CUL1

1.86e-0591153IPR016158
DomainCullin

CUL4B CUL4A CUL1

2.64e-05101153PF00888
DomainCULLIN_2

CUL4B CUL4A CUL1

2.64e-05101153PS50069
DomainCullin_N

CUL4B CUL4A CUL1

2.64e-05101153IPR001373
DomainCULLIN_1

CUL4B CUL4A CUL1

2.64e-05101153PS01256
DomainCullin_repeat-like_dom

CUL4B CUL4A CUL1

4.80e-05121153IPR016159
DomainFERM_CS

NF2 FARP1 TLN1

4.19e-04241153IPR019747
DomainHEAT_REPEAT

RANBP6 HEATR1 MROH7 PRKDC

9.15e-04701154PS50077
DomainFERM_N

NF2 FARP1 TLN1

1.08e-03331153IPR018979
DomainFERM_N

NF2 FARP1 TLN1

1.08e-03331153PF09379
DomainIQ

MYH7 MYO3B SCN7A MYO16

1.58e-03811154SM00015
DomainMyosin_head_motor_dom

MYH7 MYO3B MYO16

1.64e-03381153IPR001609
DomainMYOSIN_MOTOR

MYH7 MYO3B MYO16

1.64e-03381153PS51456
DomainMyosin_head

MYH7 MYO3B MYO16

1.64e-03381153PF00063
DomainMYSc

MYH7 MYO3B MYO16

1.64e-03381153SM00242
DomainGDS_CDC24_CS

TIAM1 FARP1 ARHGEF3

1.77e-03391153IPR001331
DomainP-loop_NTPase

MYH7 GBP3 ARHGAP35 TRANK1 ABCA6 SBNO1 MYO3B GNL2 DYNC1LI1 MFN2 WSCD2 UCK2 MYO16

2.16e-0384811513IPR027417
DomainIQ_motif_EF-hand-BS

MYH7 MYO3B SCN7A MYO16

2.32e-03901154IPR000048
DomainFERM_M

NF2 FARP1 TLN1

2.85e-03461153PF00373
Domain-

EPS8 GRK3 TIAM1 NF2 FARP1 TLN1 ARHGEF3 PLCH1

2.90e-0339111582.30.29.30
DomainHEAT

RANBP6 HEATR1 PRKDC

3.21e-03481153PF02985
Domain-

NF2 FARP1 TLN1

3.41e-034911531.20.80.10
DomainFERM_central

NF2 FARP1 TLN1

3.41e-03491153IPR019748
DomainFERM_domain

NF2 FARP1 TLN1

3.41e-03491153IPR000299
DomainFERM/acyl-CoA-bd_prot_3-hlx

NF2 FARP1 TLN1

3.61e-03501153IPR014352
DomainFERM_1

NF2 FARP1 TLN1

3.61e-03501153PS00660
DomainFERM_2

NF2 FARP1 TLN1

3.61e-03501153PS00661
DomainFERM_3

NF2 FARP1 TLN1

3.61e-03501153PS50057
DomainBand_41_domain

NF2 FARP1 TLN1

3.61e-03501153IPR019749
DomainB41

NF2 FARP1 TLN1

3.61e-03501153SM00295
DomainPH_dom-like

EPS8 GRK3 TIAM1 NF2 FARP1 TLN1 ARHGEF3 PLCH1

4.86e-034261158IPR011993
DomainARM-type_fold

RANBP6 APOB HEATR1 NOM1 ANKAR MROH7 PRKDC

5.02e-033391157IPR016024
DomainHEAT

RANBP6 HEATR1 PRKDC

5.49e-03581153IPR000357
DomainUbiquitin-rel_dom

RASSF5 NF2 FARP1 TLN1 USP47

5.64e-031841155IPR029071
DomainBRCT

NBN PES1

6.00e-03191152PF00533
PathwayKEGG_MEDICUS_PATHOGEN_HIV_VPR_TO_CDC25_CELL_CYCLE_G2M

CUL4B CUL4A CCNB3

3.49e-0511863M47573
Pubmed

A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.

FXR2 NUDT21 COPB2 NBN HMMR ARHGAP35 STT3B RIOX2 FAM193A NF2 KLHL7 SYNJ2 FARP1 NOM1 TLN1 OXSR1 CAMSAP1 IMP3

4.26e-117241171836232890
Pubmed

Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.

CUL4B CUL1 EPS8 ACADVL MAPKAPK2 TTC14 DTX3L SNX33 ARHGAP35 RIOX2 AKAP9 NFKB1 SLC35A2 PDE4DIP ITPRIP DLST

1.50e-096891171636543142
Pubmed

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.

CUL1 COG2 FXR2 NUDT21 COPB2 RANBP6 HEATR1 COG3 PDIA3 STT3B NOM1 TLN1 NFKB1 SYNE2 PES1 GNL2 DYNC1LI1 DLST PRKDC IMP3

7.07e-0814401172030833792
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

EPS15 ACADVL CCDC18 NBN HEATR1 HMMR PDIA3 STT3B TBC1D31 FAM193A AKAP9 TIAM1 NF2 FARP1 TLN1 SYNE2 PES1 GNL2 DLST PLCH1

1.19e-0714871172033957083
Pubmed

TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1.

CUL4A CUL1 FXR2 NUDT21 COPB2 PHF6 APOB HEATR1 STT3B RIOX2 NF2 NOM1 PES1 GNL2 PRKDC DUSP11

1.28e-079491171636574265
Pubmed

HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.

CUL1 FXR2 NUDT21 PHF6 APOB SNX33 HMMR PDIA3 KNOP1 LGALS8 RIOX2 AKAP9 FARP1 NOM1 TLN1 PES1 GNL2 DLST DUSP11

1.62e-0713711171936244648
Pubmed

An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.

CUL4B EPS15 FXR2 NBN STT3B SPDL1 TBC1D31 FAM193A SYNJ2 PES1 GNL2 DYNC1LI1 PLCH1 CAMSAP1

1.88e-077331171434672954
Pubmed

The human cytoplasmic dynein interactome reveals novel activators of motility.

CUL4B EPS8 FXR2 NBN IFT46 TBC1D31 KLHL7 SYNJ2 FARP1 TLN1 NFKB1 DYNC1LI1 CAMSAP1 CFAP97 USP47

1.92e-078531171528718761
Pubmed

Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.

CUL4B CUL1 COPB2 PHF6 HMMR PDIA3 CMC2 STT3B SBNO1 TLN1 OXSR1 PRKDC CWF19L1

3.32e-076531171333742100
Pubmed

Characterization of the mammalian family of DCN-type NEDD8 E3 ligases.

CUL4B CUL4A CUL1 ACADVL

3.59e-0718117426906416
Pubmed

Isoform-specific and ubiquitination dependent recruitment of Tet1 to replicating heterochromatin modulates methylcytosine oxidation.

CUL4B CUL4A TET1

3.69e-075117336056023
Pubmed

Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.

STARD13 EPS15 NUDT21 COPB2 PHF6 HEATR1 ARHGAP35 PDIA3 KNOP1 TIAM1 FARP1 TLN1 DYNC1LI1 ARHGEF3 DOCK6

4.72e-079161171532203420
Pubmed

A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex.

NUDT21 UBA2 NBN HEATR1 HMMR ARHGAP35 PDIA3 SPDL1 NF2 DYNC1LI1 CAMSAP1

6.11e-074721171138943005
Pubmed

cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family.

CUL4B CUL4A CUL1

7.37e-07611738681378
Pubmed

E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification.

CUL4B CUL4A CUL1 UBA2

1.03e-0623117419250909
Pubmed

Proximity interactions of the ubiquitin ligase Mind bomb 1 reveal a role in regulation of epithelial polarity complex proteins.

CUL4B CUL4A EPS15 CCDC18 ARHGAP35 TBC1D31 SYNJ2

1.79e-06169117731462741
Pubmed

A high-throughput approach for measuring temporal changes in the interactome.

CUL4B CUL4A CUL1 EPS15 NUDT21 COPB2 UBA2 RANBP6 COG3 PDIA3 SPDL1 SBNO1 TLN1 PES1 DYNC1LI1 OXSR1 PRKDC USP47

1.81e-0614551171822863883
Pubmed

Covalent modification of all members of human cullin family proteins by NEDD8.

CUL4B CUL4A CUL1

2.05e-068117310597293
Pubmed

The replication initiation determinant protein (RepID) modulates replication by recruiting CUL4 to chromatin.

CUL4B CUL4A CUL1

2.05e-068117330018425
Pubmed

The Cul4-DDB1-WDR3/WDR6 Complex Binds SPAK and OSR1 Kinases in a Phosphorylation-Dependent Manner.

CUL4B CUL4A OXSR1

2.05e-068117331614064
Pubmed

CAND1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex.

CUL4B CUL4A CUL1

2.05e-068117312504026
Pubmed

Intersectin (ITSN) family of scaffolds function as molecular hubs in protein interaction networks.

EPS15 SPDL1 TIAM1 SYNJ2 PDE4DIP TRIM8

2.16e-06111117622558309
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

EPS8 EPS15 NSD1 PHF6 NBN HEATR1 HMMR STT3B KNOP1 LGALS8 RIOX2 FARP1 NOM1 TLN1 PES1 GNL2 IMP3 DUSP11

2.69e-0614971171831527615
Pubmed

A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.

CUL4B CUL4A CUL1 EPS15 COG2 ACADVL UBA2 NBN DYNC1LI1 UCK2 DLST

3.19e-065601171135241646
Pubmed

N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.

EPS15 PHF6 NBN HEATR1 ARHGAP35 PDIA3 KNOP1 RASSF5 FAM193A TLN1 PES1 GNL2 PRKDC CAMSAP1

3.27e-069341171433916271
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

CUL1 NUDT21 COPB2 PHF6 APOB HEATR1 PDIA3 STT3B SPDL1 RIOX2 SBNO1 TLN1 PES1 GNL2 DYNC1LI1 DLST PRKDC

5.83e-0614251171730948266
Pubmed

TIP120A associates with cullins and modulates ubiquitin ligase activity.

CUL4B CUL4A CUL1

6.00e-0611117312609982
Pubmed

SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation.

CUL4B CUL4A CUL1

7.98e-0612117318826954
Pubmed

NEDD8 links cullin-RING ubiquitin ligase function to the p97 pathway.

CUL4B CUL4A CUL1

7.98e-0612117322466964
Pubmed

The human Dcn1-like protein DCNL3 promotes Cul3 neddylation at membranes.

CUL4B CUL4A CUL1

7.98e-0612117319617556
Pubmed

KEAP1 Mutations Drive Tumorigenesis by Suppressing SOX9 Ubiquitination and Degradation.

CUL4B CUL4A CUL1

7.98e-0612117333173725
Pubmed

Defining the membrane proteome of NK cells.

EPS15 FXR2 OAS2 HEATR1 HMMR STT3B LGALS8 NF2 PES1 GNL2 DYNC1LI1 ITPRIP DLST PRKDC IL6ST

9.17e-0611681171519946888
Pubmed

Structural conservation of distinctive N-terminal acetylation-dependent interactions across a family of mammalian NEDD8 ligation enzymes.

CUL4B CUL4A CUL1

1.04e-0513117323201271
Pubmed

N-glycosylation of the human β1,4-galactosyltransferase 4 is crucial for its activity and Golgi localization.

SLC35A2 B4GALT4

1.12e-052117232827291
Pubmed

Dysregulation of CUL4A and CUL4B Ubiquitin Ligases in Lung Cancer.

CUL4B CUL4A

1.12e-052117227974468
Pubmed

Detailed mapping, mutation analysis, and intragenic polymorphism identification in candidate Noonan syndrome genes MYL2, DCN, EPS8, and RPL6.

EPS8 DCN

1.12e-052117211185075
Pubmed

Carcinoma matrix controls resistance to cisplatin through talin regulation of NF-kB.

TLN1 NFKB1

1.12e-052117221720550
Pubmed

Iron-inhibited autophagy via transcription factor ZFP27 in Parkinson's disease.

ZNF585A ZNF585B

1.12e-052117237668106
Pubmed

Role of cysteine-protease CGHC motifs of ER-60, a protein disulfide isomerase, in hepatic apolipoprotein B100 degradation.

APOB PDIA3

1.12e-052117223827315
Pubmed

Mutations in Cullin 4B result in a human syndrome associated with increased camptothecin-induced topoisomerase I-dependent DNA breaks.

CUL4B CUL4A

1.12e-052117220064923
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

COPB2 CCDC18 NBN PDIA3 TBC1D31 AKAP9 TIAM1 NF2 FARP1 CRLF3 NFKB1 SYNE2 PES1 GNL2

1.22e-0510491171427880917
Pubmed

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.

CUL1 EPS15 MYH7 MAPKAPK2 TTC14 SNX33 HMMR STT3B RASSF5 AKAP9 TLN1 PDE4DIP CFAP97

1.25e-059101171336736316
Pubmed

Herpes virus deneddylases interrupt the cullin-RING ligase neddylation cycle by inhibiting the binding of CAND1.

CUL4B CUL4A CUL1

1.31e-0514117322474075
Pubmed

Interactions between the otitis media gene, Fbxo11, and p53 in the mouse embryonic lung.

CUL4B CUL4A CUL1

1.31e-0514117326471094
Pubmed

ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity.

CUL4B CUL4A CUL1

1.31e-0514117310230407
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

CUL4B FXR2 COPB2 NSD1 HEATR1 TLN1 SYNE2 PES1 GNL2 PRKDC USP47

1.35e-056531171122586326
Pubmed

Latent CSN-CRL complexes are crucial for curcumin-induced apoptosis and recruited during adipogenesis to lipid droplets via small GTPase RAB18.

CUL4B CUL4A CUL1

1.64e-0515117337091236
Pubmed

Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS.

MAPKAPK2 HEATR1 HMMR RASSF5 GRK3 AKAP9 PDE4DIP OXSR1 PRKDC

1.64e-05432117923455922
Pubmed

The E3 ubiquitin ligase FBXL6 controls the quality of newly synthesized mitochondrial ribosomal proteins.

CUL1 COPB2 PHF6 RANBP6 STT3B SYNJ2 PES1 GNL2 PRKDC CAMSAP1

1.69e-055471171037267103
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

NUDT21 NSD1 NBN HEATR1 ARHGAP35 SPDL1 NF2 TLN1 TET1 PRKDC

1.74e-055491171038280479
Pubmed

Fbxl17 is rearranged in breast cancer and loss of its activity leads to increased global O-GlcNAcylation.

CUL1 COG2 IFT46 KLHL7

1.78e-0546117431560077
Pubmed

Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.

STARD13 CUL1 ACADVL COPB2 GBP3 COG3 PDIA3 AKAP9 TLN1 TDRD10 PRKDC MYO16

1.86e-058071171230575818
Pubmed

CAND1 enhances deneddylation of CUL1 by COP9 signalosome.

CUL4B CUL4A CUL1

2.01e-0516117316036220
Pubmed

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.

FXR2 NUDT21 PHF6 HEATR1 HMMR STT3B KNOP1 LGALS8 KLHL7 NOM1 PES1 GNL2 DLST PRKDC IMP3

2.16e-0512571171536526897
Pubmed

Histopathology reveals correlative and unique phenotypes in a high-throughput mouse phenotyping screen.

STARD13 EPS15 AKAP9 NFKB1

2.29e-0549117424652767
Pubmed

Proteomic and Biochemical Comparison of the Cellular Interaction Partners of Human VPS33A and VPS33B.

CCDC18 HMMR TBC1D31 FARP1 SYNE2 CAMSAP1 USP47

2.37e-05251117729778605
Pubmed

Identification of Human Neuronal Protein Complexes Reveals Biochemical Activities and Convergent Mechanisms of Action in Autism Spectrum Disorders.

FXR2 AKAP9 FARP1 SYNE2 PRKDC

2.42e-05101117526949739
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

STARD13 MYH7 ACADVL APOB HEATR1 PDIA3 STT3B KNOP1 TBC1D31 SBNO1 SYNE2 PES1 CFAP74 DLST PRKDC PLCH1

2.73e-0514421171635575683
Pubmed

Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.

FXR2 NUDT21 HEATR1 PDIA3 KNOP1 FARP1 NOM1 PES1 GNL2 DLST PRKDC IMP3

2.98e-058471171235850772
Pubmed

A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.

CUL1 EPS8 EPS15 AIDA SNX33 PDIA3 STT3B LGALS8 SYNJ2 ITPRIP MCOLN3

3.26e-057191171135337019
Pubmed

Nuclear receptor binding SET domain protein 1 promotes epithelial-mesenchymal transition in paclitaxel-resistant breast cancer cells via regulating nuclear factor kappa B and F-box and leucine-rich repeat protein 11.

NSD1 NFKB1

3.36e-053117234905470
Pubmed

FAP is critical for ovarian cancer cell survival by sustaining NF-κB activation through recruitment of PRKDC in lipid rafts.

NFKB1 PRKDC

3.36e-053117236494579
Pubmed

The tumor suppressor gene, RASSF1A, is essential for protection against inflammation -induced injury.

RASSF5 NFKB1

3.36e-053117224146755
Pubmed

CUL4 E3 ligase regulates the proliferation and apoptosis of lung squamous cell carcinoma and small cell lung carcinoma.

CUL4B CUL4A

3.36e-053117232587774
Pubmed

Structural mechanism of nuclear transport mediated by importin β and flexible amphiphilic proteins.

CUL4B CUL1

3.36e-053117225435324
Pubmed

Molecular Pathway of Microtubule Organization at the Golgi Apparatus.

AKAP9 PDE4DIP

3.36e-053117227666745
Pubmed

Tiam1 interaction with the PAR complex promotes talin-mediated Rac1 activation during polarized cell migration.

TIAM1 TLN1

3.36e-053117223071154
Pubmed

CUL4high Lung Adenocarcinomas Are Dependent on the CUL4-p21 Ubiquitin Signaling for Proliferation and Survival.

CUL4B CUL4A

3.36e-053117234119472
Pubmed

Loss and gain of function of Grp75 or mitofusin 2 distinctly alter cholesterol metabolism, but all promote triglyceride accumulation in hepatocytes.

APOB MFN2

3.36e-053117234419589
Pubmed

Expression of the receptor tyrosine kinase substrate genes eps8 and eps15 during mouse development.

EPS8 EPS15

3.36e-05311727566980
Pubmed

Cullin4B/E3-ubiquitin ligase negatively regulates beta-catenin.

CUL4B CUL4A

3.36e-053117217954973
Pubmed

E3 ubiquitin ligase Cullin4B mediated polyubiquitination of p53 for its degradation.

CUL4B CUL4A

3.36e-053117224452595
Pubmed

TCR-transgenic lymphocytes specific for HMMR/Rhamm limit tumor outgrowth in vivo.

HMMR PRKDC

3.36e-053117222371883
Pubmed

A Hypoxia-Induced SCFFBXL1 E3 Ligase Ubiquitinates and Degrades the MEN1 Tumor Suppressor to Promote Colorectal Cancer Tumorigenesis.

CUL1 TIAM1 NF2 PRKDC

3.63e-0555117434237211
Pubmed

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.

CUL4B STARD13 CUL4A IFT46 SNX33 HEATR1 HMMR PDIA3 STT3B TIAM1 SBNO1 KLHL7 NFKB1 DYNC1LI1 UCK2

3.83e-0513211171527173435
Pubmed

COMMD1 (copper metabolism MURR1 domain-containing protein 1) regulates Cullin RING ligases by preventing CAND1 (Cullin-associated Nedd8-dissociated protein 1) binding.

CUL4B CUL4A CUL1

4.06e-0520117321778237
Pubmed

Inhibition of N-glycan processing modulates the network of EDEM3 interactors.

COPB2 UBA2 PDIA3 STT3B

4.19e-0557117428366632
Pubmed

CUL7: A DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex.

CUL4B CUL4A CUL1

4.72e-0521117312481031
Pubmed

Molecular Characterization of the Oncogene BTF3 and Its Targets in Colorectal Cancer.

MYH7 ACADVL FXR2 NUDT21 PHF6 PDIA3 LGALS8 FARP1 DLST PRKDC

5.28e-056261171033644029
Pubmed

The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.

FXR2 COPB2 PHF6 HEATR1 HMMR KNOP1 RIOX2 NOM1 GNL2 DLST PRKDC

5.31e-057591171135915203
Pubmed

Coupled monoubiquitylation of the co-E3 ligase DCNL1 by Ariadne-RBR E3 ubiquitin ligases promotes cullin-RING ligase complex remodeling.

CUL4B CUL4A CUL1

5.45e-0522117330587576
Pubmed

The functional interactome landscape of the human histone deacetylase family.

MIER3 HEATR1 PDIA3 SYNE2 PES1 PRKDC USP47

5.79e-05289117723752268
Pubmed

The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.

CUL4B CUL1 NUDT21 COPB2 PHF6 HEATR1 TLN1 PES1 DYNC1LI1 PRKDC

6.18e-056381171033239621
Pubmed

mTOR drives its own activation via SCF(βTrCP)-dependent degradation of the mTOR inhibitor DEPTOR.

CUL1 NFKB1 USP47

6.26e-0523117322017875
Pubmed

MK2 controls the level of negative feedback in the NF-kappaB pathway and is essential for vascular permeability and airway inflammation.

MAPKAPK2 NFKB1

6.70e-054117217576778
Pubmed

Human immunodeficiency virus type 1 Vpr induces the degradation of the UNG and SMUG uracil-DNA glycosylases.

CUL4A CUL1

6.70e-054117216103149
Pubmed

Whole-exome sequencing reveals frequent genetic alterations in BAP1, NF2, CDKN2A, and CUL1 in malignant pleural mesothelioma.

CUL1 NF2

6.70e-054117225488749
Pubmed

Roles for NBS1 in alternative nonhomologous end-joining of V(D)J recombination intermediates.

NBN PRKDC

6.70e-054117219362533
Pubmed

Genotoxic stress targets human Chk1 for degradation by the ubiquitin-proteasome pathway.

CUL4A CUL1

6.70e-054117216137618
Pubmed

Inflammation-dependent downregulation of miR-194-5p contributes to human intervertebral disc degeneration by targeting CUL4A and CUL4B.

CUL4B CUL4A

6.70e-054117230945295
Pubmed

Proximity Labeling, Quantitative Proteomics, and Biochemical Studies Revealed the Molecular Mechanism for the Inhibitory Effect of Indisulam on the Proliferation of Gastric Cancer Cells.

CUL4B CUL4A

6.70e-054117234420308
Pubmed

CRL4s: the CUL4-RING E3 ubiquitin ligases.

CUL4B CUL4A

6.70e-054117219818632
Pubmed

MDC1 regulates DNA-PK autophosphorylation in response to DNA damage.

NBN PRKDC

6.70e-054117215377652
Pubmed

Phosphorylation of p50 NF-kappaB at a single serine residue by DNA-dependent protein kinase is critical for VCAM-1 expression upon TNF treatment.

NFKB1 PRKDC

6.70e-054117220966071
Pubmed

Essential role of the CUL4B ubiquitin ligase in extra-embryonic tissue development during mouse embryogenesis.

CUL4B CUL4A

6.70e-054117222453236
Pubmed

Cullin 4B is recruited to tristetraprolin-containing messenger ribonucleoproteins and regulates TNF-α mRNA polysome loading.

CUL4B CUL4A

6.70e-054117222262661
Pubmed

The p300/YY1/miR-500a-5p/HDAC2 signalling axis regulates cell proliferation in human colorectal cancer.

CUL4B CUL4A ACADVL FXR2 DTX3L HMMR PRKDC

7.01e-05298117730737378
Pubmed

A general approach for investigating enzymatic pathways and substrates for ubiquitin-like modifiers.

CUL4B CUL1 UBA2

7.13e-0524117316620772
Pubmed

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

NUDT21 COPB2 ARHGAP35 STT3B KNOP1 FARP1 PES1 GNL2 DYNC1LI1 DLST PRKDC DOCK6 IMP3

7.42e-0510821171338697112
Pubmed

Mouse screen reveals multiple new genes underlying mouse and human hearing loss.

STARD13 EPS15 COG2 SLITRK4 CCDC18 UBA2 DCN AKAP9 SYNJ2 NOM1 CRLF3 NFKB1 TET1 MROH7

7.64e-0512421171430973865
InteractionNPM1 interactions

CUL4B CUL4A CUL1 KANSL1L MYH7 FXR2 NUDT21 NSD1 PHF6 RANBP6 SPDL1 KNOP1 RIOX2 CFAP54 NOM1 SYNE2 PES1 PDE4DIP GNL2 PRKDC IMP3 DUSP11

7.46e-07120111322int:NPM1
InteractionARHGAP26 interactions

STARD13 EPS8 NUDT21 ARHGAP35 KLHL7 SYNE2 MYO16

5.10e-061201137int:ARHGAP26
InteractionIGHV3OR15-7 interactions

CUL4B CUL4A CUL1

2.00e-05101133int:IGHV3OR15-7
InteractionPRICKLE1 interactions

STARD13 EPS8 ARHGAP35 KLHL7 SYNE2

2.17e-05601135int:PRICKLE1
InteractionRASSF1 interactions

CUL4A CUL1 RASSF5 NF2 ITPRIP PRKDC

2.50e-051031136int:RASSF1
InteractionPRICKLE2 interactions

STARD13 EPS8 ARHGAP35 KLHL7 SYNE2

2.54e-05621135int:PRICKLE2
InteractionPCBD1 interactions

CUL4B CUL4A CUL1 FXR2 PHF6 NFKB1

2.64e-051041136int:PCBD1
InteractionDCAF1 interactions

CUL4B CUL4A CUL1 EPS15 NBN NF2 TET1 PRKDC

3.87e-052241138int:DCAF1
InteractionXRCC4 interactions

CUL1 NUDT21 NBN NF2 NFKB1 PRKDC

4.43e-051141136int:XRCC4
InteractionMAPRE3 interactions

CUL4A FXR2 HMMR AKAP9 SYNJ2 PDE4DIP CAMSAP1 CFAP97

4.66e-052301138int:MAPRE3
InteractionRPL7AP27 interactions

CUL4B CUL4A CUL1

4.71e-05131133int:RPL7AP27
InteractionGNAL interactions

STARD13 ARHGAP35 KLHL7 SYNE2

5.37e-05371134int:GNAL
InteractionCEACAM16 interactions

NSD1 SBNO1 OXSR1

5.97e-05141133int:CEACAM16
InteractionNFKB2 interactions

CUL4B CUL4A CUL1 EPS8 COPB2 NFKB1

6.48e-051221136int:NFKB2
InteractionATP5IF1 interactions

SH2D3C CCDC18 PHF6 PDIA3 TIAM1 NF2 GUCY2C

6.79e-051791137int:ATP5IF1
InteractionLCA5 interactions

UBA2 IFT46 KNOP1 TBC1D31 CAMSAP1 CFAP97

7.42e-051251136int:LCA5
InteractionH2AC16 interactions

CUL4B CUL4A CUL1

9.11e-05161133int:H2AC16
InteractionH2AC15 interactions

CUL4B CUL4A CUL1

9.11e-05161133int:H2AC15
InteractionDPYSL2 interactions

CUL4B CUL4A EPS15 NUDT21 RANBP6 STT3B SPDL1 MYO3B DYNC1LI1

9.50e-053271139int:DPYSL2
InteractionH2AC4 interactions

CUL4B CUL4A CUL1 FXR2 MIER3 PHF6 DTX3L PES1 DYNC1LI1 DLST PRKDC

1.30e-0450611311int:H2AC4
InteractionPPIA interactions

CUL4B CUL1 NUDT21 SH2D3C UBA2 NBN HEATR1 HMMR ARHGAP35 PDIA3 SPDL1 NF2 DYNC1LI1 DLST CAMSAP1

1.31e-0488811315int:PPIA
InteractionCDC42 interactions

CUL4A CUL1 ACADVL NUDT21 SLITRK4 PHF6 HEATR1 ARHGAP35 STT3B LGALS8 TIAM1 NF2 SBNO1 FARP1 SYNE2 DYNC1LI1 UCK2 PRKDC IL6ST

1.34e-04132311319int:CDC42
InteractionBICD2 interactions

EPS8 FXR2 PDIA3 AKAP9 SYNJ2 TLN1 NFKB1 TRIM8 DYNC1LI1 CAMSAP1

1.43e-0442611310int:BICD2
InteractionTULP3 interactions

CUL4A MYH7 PHF6 SNX33 AKAP9 PDE4DIP DYNC1LI1 DOCK6 USP47

1.46e-043461139int:TULP3
InteractionTRIM9 interactions

CUL1 DTX3L NFKB1 TRIM8 MYO16

1.52e-04901135int:TRIM9
InteractionMTTP interactions

APOB NF2 PRKDC

1.56e-04191133int:MTTP
InteractionSRGAP1 interactions

STARD13 EPS8 ARHGAP35 KLHL7 SYNE2

1.69e-04921135int:SRGAP1
InteractionTUT4 interactions

CUL4B CUL1 FXR2 DAZL SPDL1

1.97e-04951135int:TUT4
InteractionCHN2 interactions

STARD13 EPS8 ARHGAP35 KLHL7 SYNE2

2.17e-04971135int:CHN2
InteractionCUL4B interactions

CUL4B CUL4A CUL1 NUDT21 NSD1 NBN PDIA3 TIAM1 NF2 NFKB1 TET1 GNL2 OXSR1

2.22e-0472811313int:CUL4B
InteractionCD274 interactions

CUL4B CUL4A CUL1 COG2 COPB2 HEATR1 COG3 PDIA3 PRKDC

2.35e-043691139int:CD274
InteractionMOB1B interactions

FARP1 CRLF3 TLN1 DOCK6

2.39e-04541134int:MOB1B
InteractionPRNP interactions

CUL4B CUL1 EPS8 ACADVL MAPKAPK2 TTC14 DTX3L SNX33 ARHGAP35 RIOX2 AKAP9 TLN1 NFKB1 SLC35A2 PDE4DIP ITPRIP DLST

2.44e-04115811317int:PRNP
GeneFamilyCullins

CUL4B CUL4A CUL1

3.94e-0687631032
GeneFamilyComponents of oligomeric golgi complex

COG2 COG3

4.80e-048762493
GeneFamilyArmadillo repeat containing|Protein phosphatase 1 regulatory subunits

TRPC5 AKAP9 FARP1 NOM1 MYO16

9.90e-04181765694
GeneFamilyAnkyrin repeat domain containing|FERM domain containing

NF2 FARP1 TLN1

1.21e-03507631293
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

TIAM1 FARP1 ARHGEF3

2.70e-0366763722
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_DN

STARD13 CUL1 EPS8 EPS15 NBN HMMR ARHGAP35 TBC1D31 FAM193A AKAP9 TIAM1 SYNJ2 NFKB1 SYNE2 UCK2 OXSR1

1.35e-0685611716M4500
CoexpressionRODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_UP

CUL4B NUDT21 NBN HEATR1 CMC2 CHRNA5 SPDL1 KLHL7 GNL2 UCK2 PRKDC IL6ST USP47

6.29e-0664411713M10501
CoexpressionBUSSLINGER_GASTRIC_IMMUNE_CELLS

EPS15 NUDT21 SH2D3C TTC14 NSD1 UBA2 GBP3 OAS2 AIDA ARHGAP35 STT3B RASSF5 TRANK1 AKAP9 SBNO1 CRLF3 TLN1 PDE4DIP ARHGEF3 USP47

9.52e-06149211720M40023
CoexpressionERWIN_COHEN_BLOOD_LIVE_VACCINE_TC_83_AGE_23_48YO_VACCINATED_VS_CONTROL_14DY_UP

CUL4A NUDT21 TTC14 UBA2 RANBP6 GBP3 OAS2 STT3B RIOX2 ARHGEF3 CFAP97 IL6ST USP47

1.25e-0568711713M41022
CoexpressionGSE14415_ACT_TCONV_VS_ACT_NATURAL_TREG_UP

OAS2 STT3B SBNO1 CRLF3 TET1 MCOLN3 IL6ST

1.25e-051721177M2945
CoexpressionGSE21670_UNTREATED_VS_TGFB_IL6_TREATED_CD4_TCELL_UP

EPS8 CCDC18 SPDL1 TBC1D31 TIAM1 SYNE2 CAMSAP1

2.73e-051941177M7467
CoexpressionIBRAHIM_NRF2_UP

CUL1 FXR2 MIER3 NBN AIDA PDIA3 STT3B SYNJ2 DYNC1LI1 UCK2 CFAP97

2.76e-0553311711M42510
CoexpressionGSE5542_UNTREATED_VS_IFNG_TREATED_EPITHELIAL_CELLS_24H_UP

EPS15 ACADVL MAPKAPK2 SNX33 ARHGAP35 TRANK1 UCK2

3.10e-051981177M6522
CoexpressionGSE5589_LPS_VS_LPS_AND_IL10_STIM_MACROPHAGE_45MIN_UP

SH2D3C PDIA3 CMC2 KNOP1 RASSF5 FARP1 MCOLN3

3.31e-052001177M6609
CoexpressionGSE33425_CD161_HIGH_VS_NEG_CD8_TCELL_DN

EPS8 STT3B KNOP1 KLHL7 GNL2 UCK2 IL6ST

3.31e-052001177M8552
CoexpressionGSE17721_PAM3CSK4_VS_CPG_2H_BMDC_DN

CUL4A NBN APOB MFN2 ARHGEF3 IL6ST USP47

3.31e-052001177M3858
CoexpressionGSE6674_PL2_3_VS_ANTI_IGM_AND_CPG_STIM_BCELL_DN

EPS15 MAPKAPK2 PHF6 IFT46 NF2 NFKB1 ARHGEF3

3.31e-052001177M6943
CoexpressionHE_LIM_SUN_FETAL_LUNG_C5_CD5_POS_CCL22_POS_MATURE_B_CELL

CUL4B MAPKAPK2 KNOP1 TLR10 RASSF5 GRK3 ABCA6 NFKB1 SYNE2 PES1 GNL2 CFAP97

4.42e-0566611712M45778
CoexpressionGSE45365_NK_CELL_VS_CD8_TCELL_UP

OAS2 AIDA FAM193A ABCA6 SYNE2 B4GALT4

8.14e-051591176M10025
CoexpressionIBRAHIM_NRF1_UP

CUL4A CUL1 FXR2 PDIA3 SBNO1 PES1 DYNC1LI1 MFN2 UCK2

1.15e-044201179M42509
CoexpressionGSE8685_IL2_ACT_IL2_STARVED_VS_IL21_ACT_IL2_STARVED_CD4_TCELL_UP

GBP3 TBC1D31 NF2 FARP1 CAMSAP1 MCOLN3

1.34e-041741176M333
CoexpressionHOUNKPE_HOUSEKEEPING_GENES

CUL4B CUL1 FXR2 NUDT21 COPB2 UBA2 AIDA COG3 PDIA3 STT3B GNL2 DYNC1LI1 MFN2 OXSR1 DUSP11

1.53e-04112911715M42508
CoexpressionPUJANA_CHEK2_PCC_NETWORK

CUL4A UBA2 NBN HMMR CHRNA5 TBC1D31 GNL2 UCK2 DLST OXSR1 PRKDC DUSP11

1.56e-0476111712M11961
CoexpressionHOUNKPE_HOUSEKEEPING_GENES

CUL4B CUL1 FXR2 NUDT21 COPB2 UBA2 AIDA COG3 PDIA3 STT3B GNL2 DYNC1LI1 MFN2 OXSR1 DUSP11

2.02e-04115811715MM1338
CoexpressionMARTINEZ_RESPONSE_TO_TRABECTEDIN_DN

EPS8 EPS15 PHF6 UBA2 NBN CRLF3 UCK2

2.25e-042721177M15123
CoexpressionGSE21927_UNTREATED_VS_GMCSF_GCSF_TREATED_BONE_MARROW_DN

CUL4B EPS15 SH2D3C DAZL STT3B ITPRIP

2.28e-041921176M7571
CoexpressionNAKAYA_PBMC_FLUARIX_FLUVIRIN_AGE_18_50YO_CORRELATED_WITH_HAI_28DY_RESPONSE_AT_3DY_NEGATIVE

HEATR1 STT3B SYNE2 PDE4DIP DLST IL6ST USP47 DUSP11

2.30e-043631178M41103
CoexpressionGSE11864_CSF1_PAM3CYS_VS_CSF1_IFNG_PAM3CYS_IN_MAC_DN

GBP3 DTX3L TRANK1 TRIM8 ARHGEF3 CWF19L1

2.34e-041931176M3149
CoexpressionGSE3982_MAC_VS_NEUTROPHIL_DN

KANSL1L SH2D3C TRANK1 SYNE2 TRIM8 MYO16

2.48e-041951176M5492
CoexpressionLIU_VMYB_TARGETS_UP

MAPKAPK2 TBC1D31 SBNO1 KLHL7 PDE4DIP

2.49e-041251175M1584
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN

STARD13 CUL1 EPS8 EPS15 NBN AKAP9 TIAM1 UCK2 OXSR1

2.49e-044661179M13522
CoexpressionHE_LIM_SUN_FETAL_LUNG_C2_CXCL9_POS_MACROPHAGE_CELL

CUL1 GBP3 OAS2 NBN DTX3L

2.58e-041261175M45721
CoexpressionGSE25088_CTRL_VS_IL4_AND_ROSIGLITAZONE_STIM_STAT6_KO_MACROPHAGE_UP

CCDC18 ARHGAP35 AKAP9 NOM1 ST8SIA2 PRKDC

2.62e-041971176M8022
CoexpressionGSE29618_LAIV_VS_TIV_FLU_VACCINE_DAY7_MDC_UP

MAPKAPK2 NSD1 DAZL AIDA TLN1 MROH7

2.62e-041971176M5020
CoexpressionGSE1460_INTRATHYMIC_T_PROGENITOR_VS_DP_THYMOCYTE_UP

CUL1 ZNF132 NBN RIOX2 GNL2 UCK2

2.69e-041981176M3436
CoexpressionGSE3982_NEUTROPHIL_VS_TH1_DN

KNOP1 RIOX2 GNL2 IMP3 USP47 JHY

2.76e-041991176M5533
CoexpressionGSE30083_SP1_VS_SP4_THYMOCYTE_DN

SIDT1 OAS2 DTX3L CRLF3 SYNE2 PRKDC

2.84e-042001176M5030
CoexpressionGSE14308_TH1_VS_INDUCED_TREG_UP

CUL1 TTC14 PHF6 OAS2 LGALS8 PLCH1

2.84e-042001176M3378
CoexpressionGSE339_CD8POS_VS_CD4CD8DN_DC_DN

TRPC5 APOB KLHL7 CRLF3 NFKB1 ARHGEF3

2.84e-042001176M5118
CoexpressionGSE11961_PLASMA_CELL_DAY7_VS_MEMORY_BCELL_DAY40_UP

UBA2 DCN STT3B RIOX2 SLC35A2 PDE4DIP

2.84e-042001176M9384
CoexpressionGSE5542_UNTREATED_VS_IFNA_TREATED_EPITHELIAL_CELLS_24H_UP

EPS15 ACADVL MAPKAPK2 SNX33 ARHGAP35 TRANK1

2.84e-042001176M6524
CoexpressionGSE17721_0.5H_VS_4H_POLYIC_BMDC_DN

CUL4B FXR2 OAS2 TIAM1 NFKB1 IL6ST

2.84e-042001176M4091
CoexpressionGSE22886_NAIVE_CD4_TCELL_VS_NEUTROPHIL_UP

NUDT21 UBA2 RANBP6 AIDA TIAM1 IMP3

2.84e-042001176M4497
CoexpressionGOLDRATH_EFF_VS_MEMORY_CD8_TCELL_DN

TTC14 RASSF5 AKAP9 CRLF3 GNL2 IL6ST

2.84e-042001176M3044
CoexpressionGSE10239_MEMORY_VS_KLRG1HIGH_EFF_CD8_TCELL_DN

CUL4B EPS15 MIER3 SPDL1 TIAM1 FARP1

2.84e-042001176M3067
CoexpressionNAKAYA_PLASMACYTOID_DENDRITIC_CELL_FLUMIST_AGE_18_50YO_7DY_UP

CUL4B CUL4A EPS15 COG2 SIDT1 UBA2 NBN RIOX2 GRK3 SYNE2 SLC35A2 PDE4DIP OXSR1 PRKDC CAMSAP1

3.37e-04121511715M41122
ToppCellPBMC-Mild-cDC_9|Mild / Compartment, Disease Groups and Clusters

CUL1 OAS2 DTX3L HEATR1 HMMR ABCA6 TDRD10 CFAP74

3.13e-0818411782e0c9a2c40c892a2d435eafb31f1f838de9baf15
ToppCell(11)_FOXN4+-(2)_GFP_FOXI1|(11)_FOXN4+ / shred by cell type by condition

CUL1 EPS8 CCDC18 AKAP9 SBNO1 SYNE2 TRIM8

9.47e-07198117776d40b8c2f8399725b3a62ee2ae0896559cf91eb
ToppCell(03)_KRT6B+-(2)_GFP_FOXI1|(03)_KRT6B+ / shred by cell type by condition

EPS8 GBP3 AKAP9 SBNO1 SYNE2 TRIM8 CFAP97

9.80e-071991177c425e7975f492ed5cfcca022248adb627e1d27d4
ToppCellPND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_G2M|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CCDC18 HMMR DCN FAM228B TBC1D31 WSCD2

6.73e-0617411761779e67382cb2644534ffb5b9b8f28d32935f4ea
ToppCellcontrol-Myeloid-Monocyte-derived_DC|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

EPS15 DTX3L TBC1D31 PES1 IMP3

9.82e-061081175e74e73d89d78c8d59dfdd2bd30db54b366a49d23
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5_PVALB_CNTNAP3P2|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TRPC5 TIAM1 MYO3B SCN7A PLCH1 MYO16

9.84e-0618611766379609b7ace80683f5754b16aa77f11b43766ae
ToppCellT_cells-ISG-high_CD4+_T_cells|World / Immune cells in Kidney/Urine in Lupus Nephritis

GBP3 OAS2 DTX3L TRANK1 SYNE2 IL6ST

1.05e-0518811766f8946d4710f6e32c937213f99b790b098b8819c
ToppCellStriatum-Neuronal-Inhibitory-iN2(Gad1Gad2)-Inhibitory_Neuron.Gad1Gad2.Pnoc_(Fast-spiking_interneuron,_Pvalb+/Pnoc+)-|Striatum / BrainAtlas - Mouse McCarroll V32

CUL1 EXD1 TRPC5 CHRNA5 PDE11A

1.07e-0511011755496c92932195386025254b9129d69b12c8e3340
ToppCellStriatum-Neuronal-Inhibitory-iN2(Gad1Gad2)-Inhibitory_Neuron.Gad1Gad2.Pnoc_(Fast-spiking_interneuron,_Pvalb+/Pnoc+)--|Striatum / BrainAtlas - Mouse McCarroll V32

CUL1 EXD1 TRPC5 CHRNA5 PDE11A

1.07e-05110117541306a2d4a5a39569437eb123e47f98ef8afab24
ToppCellStriatum-Neuronal-Inhibitory-iN2(Gad1Gad2)-Inhibitory_Neuron.Gad1Gad2.Pnoc_(Fast-spiking_interneuron,_Pvalb+/Pnoc+)|Striatum / BrainAtlas - Mouse McCarroll V32

CUL1 EXD1 TRPC5 CHRNA5 PDE11A

1.07e-0511011751fe08060248b25329f73b80d74435c108bee1359
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SLITRK4 TTC14 AKAP9 FARP1 SYNE2 PDE4DIP

1.18e-051921176ee27d27e3d269764dbe8711d0b37ff9331a298a9
ToppCellLPS_IL1RA_TNF|World / Treatment groups by lineage, cell group, cell type

DCN PDIA3 AKAP9 ABCA6 DYNC1LI1 MYO16

1.36e-0519711760a6550dce156fc81f15b1e7830d331ca50d87d06
ToppCellCV-Mild-1|CV / Virus stimulation, Condition and Cluster

GBP3 OAS2 DTX3L TRANK1 SYNE2 ARHGEF3

1.40e-0519811764b078714c49e7befb7b113d72485e712236d35fa
ToppCell(02)_MMP9/10+-(2)_GFP_FOXI1|(02)_MMP9/10+ / shred by cell type by condition

EPS8 LGALS8 AKAP9 SYNE2 CFAP97 USP47

1.44e-05199117618a7f9ced4364f45b184bd529f32ef02c27779d3
ToppCell(09)_Interm._secr.>cil.-(2)_GFP_FOXI1|(09)_Interm._secr.>cil. / shred by cell type by condition

EPS8 AKAP9 SBNO1 SYNE2 TRIM8 USP47

1.44e-051991176fc680f85ebd3bab4c72876a19a461b0afb5f51ce
ToppCellPBMC-Severe|PBMC / Compartment, Disease Groups and Clusters

CUL1 OAS2 DTX3L PDIA3 TLN1 ARHGEF3

1.44e-051991176b428d95d3c90b28f658f652a768588a8ced4abd9
ToppCell343B-Fibroblasts-Fibroblast-G|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

DCN AKAP9 ABCA6 SCN7A MCOLN3 IL6ST

1.44e-051991176212e89d097753790061310373a1fafba773488b6
ToppCell343B-Fibroblasts-Fibroblast-G-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

DCN AKAP9 ABCA6 SCN7A MCOLN3 IL6ST

1.44e-05199117614b676aa289c0578a37be32cec3ea285c79d97cc
ToppCellLPS_IL1RA|World / Treatment groups by lineage, cell group, cell type

MAPKAPK2 GBP3 NBN TLN1 NFKB1 SYNE2

1.49e-052001176a02fa5b3c4723a6eaa3c685588666c710478dd25
ToppCellLPS_only-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB|LPS_only / Treatment groups by lineage, cell group, cell type

DCN AKAP9 ABCA6 DYNC1LI1 MYO16 IL6ST

1.49e-052001176a7ef7022b8efcaedb7319b0b43d8c4e99d788fe2
ToppCell3'-GW_trimst-1-SmallIntestine-Mesenchymal-immature_mesenchymal_cell-Mesoderm_2_(ZEB2+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

EPS8 DCN MYO3B SYNE2 MYO16 PDE11A

1.49e-052001176ac8a5d71acd4d401995babd233f0d3738e8ad2a5
ToppCellNS-control-d_0-4-Myeloid-Monocyte-derived_DC|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

EPS15 DTX3L TBC1D31 PES1 IMP3

2.15e-0512711751f9039d2a9e418c41716c3608d4d03574b71904a
ToppCellcontrol-Myeloid-Monocyte-derived_DC|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

EPS15 DTX3L TBC1D31 PES1 IMP3

2.24e-0512811754a1f7b76b64df06531db79e427eda084374ce7b5
ToppCellsaliva-Severe-critical_progression_d28-40-Myeloid-Granulocytic-Neutrophil-Neu_c5-GSTP1(high)OASL(low)|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

GBP3 OAS2 DTX3L GSDMC TRANK1

7.09e-051631175d005115aa1e1458b51de7eb719794617a4168608
ToppCellHippocampus-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1-Fibcd1-Excitatory_Neuron.Slc17a7.Fibcd1-Lypd1_(CA1_Principal_cells_(Anterior))|Hippocampus / BrainAtlas - Mouse McCarroll V32

MYH7 CHRNA5 GUCY2C PDE11A

7.14e-0584117452d167614afa9b056f2934142d3250fe5e70e806
ToppCellAdult-Mesenchymal-myofibroblast_cell|Adult / Lineage, Cell type, age group and donor

DCN ABCA6 SYNJ2 SCN7A DOCK6

7.95e-051671175d584a8548a5317bd9686b3be8246ae6ed568796b
ToppCell3'_v3-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8|lymph-node_spleen / Manually curated celltypes from each tissue

APOB AKAP9 NFKB1 SYNE2 IL6ST

8.89e-0517111752e9a20f8980b78325c52065a9c14ab3656267c05
ToppCellwk_15-18-Mesenchymal-Fibroblast-Mesenchymal_3|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

FXR2 MIER3 SLITRK4 HMMR WSCD2

9.39e-051731175b43817a6b1ed8d6b5366702343be4311c0d52d83
ToppCelldroplet-Marrow-nan-18m-Myeloid-basophil|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GBP3 ARHGAP35 PDE4DIP IL6ST B4GALT4

9.64e-05174117555cc8300489d11322724159ec7d0e1d32a702e91
ToppCellPBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

OAS2 DTX3L TRANK1 SYNE2 CFAP97

1.05e-041771175d3e6c768b88b7906f3c7fdd00ba20842212c14b1
ToppCellPBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

OAS2 DTX3L TRANK1 SYNE2 CFAP97

1.05e-041771175f8f101c772c043636bedd6b2ec81409b1d2599bf
ToppCellCOVID-19_Mild-Lymphoid_T/NK-NK_activated|COVID-19_Mild / Disease group, lineage and cell class

OAS2 DTX3L TRANK1 SYNE2 CFAP97

1.05e-0417711756978a22fef40c8b455342373abe7593f5ede0fa4
ToppCellPBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

OAS2 DTX3L TRANK1 SYNE2 CFAP97

1.05e-041771175936ab2b180a052387124f68d0c7f41c0b164e748
ToppCellPBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

OAS2 DTX3L TRANK1 SYNE2 CFAP97

1.05e-041771175d5aeda113afaa2425874394610344570c9078478
ToppCell5'-GW_trimst-2-LargeIntestine-Endothelial-blood_vessel_EC-Mature_venous_EC|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CCDC18 HMMR SPDL1 TBC1D31 ARHGEF3

1.07e-041781175ea10117026021c959ffc871fc377cdb3e161d264
ToppCellControl-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

GRK3 TIAM1 ABCA6 MYO16 MCOLN3

1.13e-04180117508ae0f5d95c45feba68ad99788f7af7ff4c979af
ToppCellPBMC-Mild-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

OAS2 TRANK1 SYNE2 CFAP97 IL6ST

1.19e-0418211751aea96ee211f7b9caef7fd385233f51be6021a73
ToppCellPBMC-Mild-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

OAS2 TRANK1 SYNE2 CFAP97 IL6ST

1.19e-041821175b427e43ee523a3ea9eca3207f3d82042f10f022a
ToppCellPBMC-Mild-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

OAS2 TRANK1 SYNE2 CFAP97 IL6ST

1.19e-041821175c0f63cfc67d61c0877b7acb2946dfb35aae8a8f5
ToppCellPBMC-Mild-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

OAS2 TRANK1 SYNE2 CFAP97 IL6ST

1.19e-0418211754cb182ef39be2044a6ad7266f332d4177591e550
ToppCellCOVID-19_Mild-Lymphoid_T/NK-CD4+_T_activated|COVID-19_Mild / Disease group, lineage and cell class

OAS2 TRANK1 SYNE2 CFAP97 IL6ST

1.22e-0418311757717fce227b4e02ed41baad8ae7dd2e22bd7c13e
ToppCellCalu_3-infected|Calu_3 / Cell line, Condition and Strain

GBP3 OAS2 DTX3L TRANK1 SYNE2

1.22e-0418311758f7f5000645f24f20a8d7700c4df1f8953a1780b
ToppCellControl-Endothelial-Endothelial-Activated_Alv_Cap|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SH2D3C GBP3 OAS2 DTX3L ARHGEF3

1.22e-041831175e81c142770f44fd902b0631bc360c5b5339d4c75
ToppCellsaliva-Severe-critical_progression_d28-40-Myeloid-Macrophage-macrophage,_alveolar-Macro_c2-CCL3L1|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

GBP3 OAS2 NBN DTX3L TRANK1

1.29e-041851175f30fb9d75cdb757b206312992aaf7485bc900f96
ToppCellLPS-IL1RA+antiTNF-Endothelial-Endothelial-Activated_Alv_Cap|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SH2D3C GBP3 OAS2 DTX3L ARHGEF3

1.35e-041871175f3397dbc23b6c2f24e2c1ba887d8f9aef3ee01a1
ToppCellcellseq2-Endothelial-Endothelial_Vascular-Endothelial_large_blood_vessel-VEC|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

KIAA1586 TRANK1 ITPRIP UCK2 B4GALT4

1.42e-041891175bccb3481ffed597c845fe860da658505316105b5
ToppCellCalu_3-infected-SARSCoV2|infected / Cell line, Condition and Strain

GBP3 OAS2 DTX3L TRANK1 SYNE2

1.49e-0419111752da876d26f37a00dbdf1ee79d724306e8b20f304
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

STARD13 EPS8 DCN ABCA6 MCOLN3

1.49e-0419111751caf726bd07fdca389e678fc16304a6ef1790423
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

STARD13 EPS8 DCN ABCA6 MCOLN3

1.49e-0419111753d60c46bced2984c27a1fcf2910bc38b31fb0148
ToppCellCOVID-19-kidney-AQP1+PLVAP+EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

SH2D3C SYNE2 ITPRIP ARHGEF3 DOCK6

1.53e-04192117527ff3621e177e7932dd44dd6baa81551ea75a874
ToppCellH1299-infected|H1299 / Cell line, Condition and Strain

ACADVL CCDC18 SPDL1 AKAP9 NOM1

1.53e-0419211759cf8049bdc3e0f81ce69042beac72b08d8f38b4e
ToppCelldroplet-Skin-nan-21m-Epithelial-stem_cell_of_epidermis|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CCDC18 HMMR CMC2 SPDL1 TBC1D31

1.53e-04192117596f23d6e8604d1cb24910d3118d8171b57c93e14
ToppCell10x5'-lymph-node_spleen-Lymphocytic_T_CD4-Tregs|lymph-node_spleen / Manually curated celltypes from each tissue

TIAM1 SYNE2 PDE4DIP ARHGEF3 IL6ST

1.53e-04192117504bd6e135733570e877af9460f87379ed0a5c5f8
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Inner_Medullary_Collecting_Duct_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SIDT1 GSDMC RASSF5 TIAM1 OXSR1

1.57e-041931175a5695ce2e24a62026ae28f3dea07ca4a435206b8
ToppCellMild_COVID-19|World / Disease group,lineage and cell class （2021.01.30）

ZNF585A OAS2 DTX3L TRANK1 ARHGEF3

1.57e-041931175325b0768827bf8701bfb7f686bb11fd8b1a41a5c
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

DCN GRK3 TIAM1 ABCA6 FARP1

1.60e-041941175b1bb0f846d2865efdd9bc8842b16b9d069785882
ToppCellControl-Myeloid-TRAM2|Control / Condition, Lineage and Cell class

GBP3 OAS2 NBN NFKB1 PDE4DIP

1.60e-041941175d951dd1274d3ff1ac30671ec4153a4a8bc97b53f
ToppCellCOVID-19_Convalescent-PLT_4|COVID-19_Convalescent / Disease Group and Platelet Clusters

KIAA1586 CMC2 LGALS8 AKAP9 DUSP11

1.60e-041941175ce1fad4e76a87f0c35e430ed1f2262395df882fd
ToppCellFrontal_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Cplx3|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

CUL1 TRPC5 MYO3B PDE11A

1.63e-041041174b5ca6e589f414e549f4990fe334d4ee54829b298
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SH2D3C SIDT1 SYNJ2 ITPRIP DUSP11

1.64e-0419511756bdef651cf73d7381e5012d0eb3c809138fb6b92
ToppCell367C-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

STARD13 EPS8 EPS15 ABCA6 FARP1

1.64e-0419511754008fa86b5166087a4b20f89ae07e1dfc87c855d
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

DCN GRK3 TIAM1 ABCA6 FARP1

1.64e-0419511750e55fa5b3cbeb7baee3d4ac272a3bf80381ec937
ToppCellB_cells-ISG-high_B_cells|B_cells / Immune cells in Kidney/Urine in Lupus Nephritis

GBP3 OAS2 DTX3L TRANK1 ARHGEF3

1.64e-041951175b64d9e1a8834401b4dc501566546647754ae21fc
ToppCellRA-02._Fibroblast_II|RA / Chamber and Cluster_Paper

EPS8 DCN TIAM1 ABCA6 SCN7A

1.64e-0419511756a02ebbeb3199447ddce64d92d8809436e040eba
ToppCell368C-Fibroblasts-Fibroblast-G|368C / Donor, Lineage, Cell class and subclass (all cells)

DCN ABCA6 SCN7A MCOLN3 IL6ST

1.72e-041971175156155c2f0c1a2461e45803da578af18ee221660
ToppCell368C-Fibroblasts-Fibroblast-G-|368C / Donor, Lineage, Cell class and subclass (all cells)

DCN ABCA6 SCN7A MCOLN3 IL6ST

1.72e-041971175d5d9263451f6c10cb3b9c17740183ca334e24851
ToppCellTCGA-Ovary-Primary_Tumor|TCGA-Ovary / Sample_Type by Project: Shred V9

PDIA3 TLN1 TRIM8 ITPRIP

1.76e-04106117414f548be39cec604fbdae0382cbf434fa4049840
ToppCellTCGA-Ovary-Primary_Tumor-Ovarian_Carcinoma|TCGA-Ovary / Sample_Type by Project: Shred V9

PDIA3 TLN1 TRIM8 ITPRIP

1.76e-041061174939b80950d39cdc7149a05fdfb64c8810064cdb1
ToppCellTCGA-Ovary-Primary_Tumor-Ovarian_Carcinoma-Serous_Cystadenocarcinoma|TCGA-Ovary / Sample_Type by Project: Shred V9

PDIA3 TLN1 TRIM8 ITPRIP

1.76e-041061174e9e1b55f32b3d5b9eeec94a997912e5c21c1fb48
ToppCellLPS_IL1RA_TNF-Mesenchymal_fibroblastic-Fibroblasts-Diff_MatrixFB|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

DCN ABCA6 DYNC1LI1 MYO16 IL6ST

1.76e-0419811750a4b19c3d5e65ecd24fc2ce80ac5276c813282c7
ToppCellControl-Control-Lymphocyte-T/NK-NK_activated|Control / Disease, condition lineage and cell class

SIDT1 OAS2 DTX3L TRANK1 SYNE2

1.76e-04198117576d5fe4e5bbe6c73a6ca409b80b5c3924e07cab7
ToppCellPBMC-Severe-Lymphocyte-T/NK-NK_cell-NK_activated|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

OAS2 DTX3L TRANK1 SYNE2 ARHGEF3

1.76e-041981175fed823d6e684d113bcc9ff3cd1803bb001aa02fa
ToppCellmLN-(1)_T_cell-(15)_Treg|mLN / shred on region, Cell_type, and subtype

TIAM1 SYNE2 PDE4DIP ARHGEF3 IL6ST

1.76e-041981175d4885f9c59b275e4e50dfcfb51c5351bebba1769
ToppCellmLN-T_cell-Treg|mLN / Region, Cell class and subclass

TIAM1 SYNE2 PDE4DIP ARHGEF3 IL6ST

1.76e-0419811756ce9681d1287632956176239f223e71abb8de44f
ToppCellPBMC-Severe-Lymphocyte-T/NK-NK_cell-NK_activated-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

OAS2 DTX3L TRANK1 SYNE2 ARHGEF3

1.76e-0419811751ef3a6bd681c223eed58300348adfef89df5563c
ToppCellTracheal-10x5prime-Stromal-Peri/Epineurial_-NAF_endoneurial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

STARD13 DCN ABCA6 SCN7A MYO16

1.76e-0419811757a0c4dbc8c99968d42af00a718f4fedc544599ec
ToppCellControl-Control-Lymphocyte-T/NK-CD4+_T_activated|Control / Disease, condition lineage and cell class

ZNF132 OAS2 DTX3L TRANK1 SYNE2

1.76e-041981175ee71543559836fd59adc0da877b2ca538cba60cb
ToppCell(10)_Ciliated-(2)_GFP_FOXI1|(10)_Ciliated / shred by cell type by condition

AKAP9 SBNO1 SYNE2 TRIM8 CFAP97

1.81e-04199117561b1ed2db71b96157b92b7535d1955a4033098da
ToppCellkidney_cells-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SH2D3C TIAM1 SYNE2 ITPRIP IL6ST

1.81e-0419911755d976d57872a8a25a11fe8cd53b01aa21a1a519a
ToppCellLPS_IL1RA-Mesenchymal_fibroblastic-Fibroblasts-Diff_MatrixFB|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

DCN ABCA6 DYNC1LI1 MYO16 IL6ST

1.81e-04199117538ed3bc7daa993d9edcf3e7834597ebb06dd24f8
ToppCell(00)_Basal-(2)_GFP_FOXI1|(00)_Basal / shred by cell type by condition

AKAP9 SBNO1 SYNJ2 SYNE2 CFAP97

1.81e-04199117519674e1eaeb51e4196d847cb62aa437c852951d3
ToppCell(04)_Interm._basal>secr.-(2)_GFP_FOXI1|(04)_Interm._basal>secr. / shred by cell type by condition

EPS8 AKAP9 SBNO1 SYNE2 TRIM8

1.81e-04199117553ca3861f9e00dab3f3fbefb0837857ee39ab084
ToppCell(5)_Fibroblast-G|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

DCN ABCA6 SCN7A MCOLN3 IL6ST

1.81e-041991175b4a737575be9f8c65771832dd8cd25328d5dae0d
ToppCellLPS_only-Mesenchymal_fibroblastic|LPS_only / Treatment groups by lineage, cell group, cell type

DCN ABCA6 DYNC1LI1 MYO16 IL6ST

1.81e-041991175211c3a08f2d484ab7a3368006767289088f0d957
ToppCellkidney_cells-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

KANSL1L SLITRK4 AKAP9 TLN1 IL6ST

1.81e-041991175174f6013af6eafa577f84205a62927f2b367fda3
ToppCellLPS_IL1RA_TNF-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

DCN ABCA6 DYNC1LI1 MYO16 IL6ST

1.81e-041991175e1849505b92820a219c5a2c35492bdd55579fb48
ToppCell(05)_Secretory-(2)_GFP_FOXI1|(05)_Secretory / shred by cell type by condition

EPS8 AKAP9 SBNO1 SYNE2 ITPRIP

1.81e-041991175d72d87e1e530ed894c0ad5e7b5b2b1d6b59fa098
ToppCellcontrol-Epithelial-Secretory|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

NSD1 PDIA3 KNOP1 LGALS8 IL6ST

1.81e-0419911753d01f90ffd271ca00129192787e4921bdca7e01e
ToppCellTCGA-Stomach-Primary_Tumor|TCGA-Stomach / Sample_Type by Project: Shred V9

HEATR1 HMMR SPDL1 KNOP1 GNL2

1.81e-04199117538f1f612b29feb868322999ceeda78e52447ec4f
ToppCellLPS_only-Mesenchymal_fibroblastic-Fibroblasts|LPS_only / Treatment groups by lineage, cell group, cell type

DCN ABCA6 DYNC1LI1 MYO16 IL6ST

1.81e-0419911751a0add79f4e34078b3475eb11c85a4234bda197c
ToppCellTCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma|TCGA-Stomach / Sample_Type by Project: Shred V9

HEATR1 HMMR SPDL1 KNOP1 GNL2

1.81e-041991175b10698aee2e6c17bc559eb4f723024141f914b90
ToppCellLPS_anti-TNF-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

DCN AKAP9 ABCA6 MYO16 IL6ST

1.85e-0420011759b0916d8d07ac2bf1739f7be5296bf77ffee6094
ToppCellLPS_only-Mesenchymal_fibroblastic-Fibroblasts-Diff_MatrixFB|LPS_only / Treatment groups by lineage, cell group, cell type

DCN ABCA6 DYNC1LI1 MYO16 IL6ST

1.85e-042001175ab4fda0cc95cb8f80ea9f28745013f3248def820
ToppCellNeuronal-Inhibitory-iB-iB_2(PVALB)-SULF1--L4-6|Neuronal / cells hierarchy compared to all cells using T-Statistic

TRPC5 MYO3B SCN7A PLCH1 MYO16

1.85e-0420011754a426ef88376d8bb2b9dc50aa06e7b9fc50ecc9c
ToppCellLPS_only-Endothelial|LPS_only / Treatment groups by lineage, cell group, cell type

SH2D3C GBP3 SYNE2 ARHGEF3 DOCK6

1.85e-04200117581e76508c9050d533853d5fd2f3097b27613d836
ToppCellLPS_IL1RA_TNF-Endothelial-Endothelial-Activated_Alv_Cap|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

SH2D3C GBP3 OAS2 SYNE2 ARHGEF3

1.85e-04200117589821a264e872ed53e08e9d3609d5cc5c314503e
ToppCellLPS_anti-TNF-Mesenchymal_fibroblastic-Fibroblasts-Diff_MatrixFB|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

DCN ABCA6 DYNC1LI1 MYO16 IL6ST

1.85e-0420011753bdba9612cd7c612b76aa9abecc4a6529aabfc1c
ToppCellLPS_IL1RA-Endothelial-Endothelial-Activated_Alv_Cap|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

SH2D3C GBP3 OAS2 SYNE2 ARHGEF3

1.85e-04200117579e51afb57ca38aacebd0298e5e727b55c0cfff9
ToppCellCOVID-19-COVID-19_Mild-Lymphocyte-T/NK-CD4+_T_activated|COVID-19_Mild / Disease, condition lineage and cell class

OAS2 DTX3L TRANK1 SYNE2 IL6ST

1.85e-042001175d9e8a0d047d4403fb7265fde7448e23a7780785c
ToppCell3'-GW_trimst-1-SmallIntestine-Mesenchymal-immature_mesenchymal_cell|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

EPS8 DCN MYO3B SYNE2 PDE11A

1.85e-0420011753dacd0afe69bc16bb33336ea9ea99a9cd47731d9
DrugPseudopelletierine hydrochloride [6164-62-1]; Down 200; 21uM; MCF7; HT_HG-U133A

MAPKAPK2 ARHGAP35 NF2 SLC35A2 PDE4DIP MFN2 CWF19L1 MCOLN3

6.88e-0619211782766_DN
DrugCefaclor [70356-03-5]; Down 200; 10.4uM; MCF7; HT_HG-U133A

ARHGAP35 AKAP9 SYNJ2 PDE4DIP PLCH1 NALF2 IL6ST B4GALT4

8.00e-0619611782843_DN
DrugHydrastine hydrochloride [5936-28-7]; Down 200; 9.6uM; MCF7; HT_HG-U133A

KANSL1L FXR2 OAS2 NBN NF2 SLC35A2 ARHGEF3 PLCH1

8.30e-0619711786011_DN
Diseasemitogen-activated protein kinase 14 measurement

MAPKAPK2 ARHGEF3

4.43e-0531142EFO_0020578
DiseaseMalignant neoplasm of breast

NBN DTX3L HMMR PANX2 COG3 CMC2 AKAP9 NF2 SBNO1 SYNJ2 FARP1 SYNE2 SLC35A2 MROH7

6.98e-05107411414C0006142
Diseaseprotein-tyrosine kinase 2-beta measurement

APOB ARHGEF3

8.83e-0541142EFO_0801969
Diseasesplicing factor 3B subunit 4 measurement

MFN2 ARHGEF3

1.47e-0451142EFO_0803100
Diseaseinterleukin-6 receptor measurement

TDRD10 IL6ST

1.47e-0451142EFO_0004814
DiseaseX-Linked Emery-Dreifuss Muscular Dystrophy

MYH7 SYNE2

3.07e-0471142C0751337
Diseasecolorectal cancer

STARD13 UBA2 RANBP6 GSDMC FAM193A SYNJ2 PLCH1 CAMSAP1 MYO16

5.73e-046041149MONDO_0005575
Diseaseapolipoprotein B to apolipoprotein A1 ratio

APOB ABCA6 DOCK6

9.09e-04491143EFO_0021897
Diseaseputamen volume change measurement

SH2D3C MYO16

1.12e-03131142EFO_0021495
DiseaseMetastatic melanoma

GUCY2C OXSR1 PRKDC

1.21e-03541143C0278883
Diseasealpha synuclein measurement

COG2 OXSR1

2.17e-03181142EFO_0009323
Diseaseasthma, allergic disease

EXD1 RANBP6 TLR10

3.59e-03791143MONDO_0004979, MONDO_0005271
DiseaseHDL cholesterol change measurement

SYNE2 DOCK6

3.86e-03241142EFO_0007805

Protein segments in the cluster

PeptideGeneStartEntry
DGFLKHVNKKGNAFI

FAM228B

111

P0C875
QHVLFGKFAQIIQEK

AKAP9

2276

Q99996
DKIFNQKIGFLLFKD

GRK3

56

P35626
RQKEVHFFLKKFLQL

CFAP54

2846

Q96N23
LKNNRGVKLHVFLFQ

ARHGEF3

341

Q9NR81
LNHLLKAFLQLDKKG

CFAP97

346

Q9P2B7
HQAEGKKFNRAKLLN

B4GALT4

161

O60513
VAHFLEKQGFKQQAL

COPB2

621

P35606
FKHLQEEVFQKIKTL

GSDMC

316

Q9BYG8
NLSLFAKIKGIHLKE

ABCA6

576

Q8N139
LQKHVEKLTKGAAIF

AIDA

226

Q96BJ3
QRLKLGKAAFLHVVK

CAMSAP1

906

Q5T5Y3
FLGTLENEHLKKFQV

FAM193A

51

P78312
HGKVFFLKKQLALNE

CCNB3

756

Q8WWL7
AVHNLKAVFKGRDQK

MROH7

1061

Q68CQ1
KVTKTIKNGFLHFEN

NSD1

141

Q96L73
AIKKHIGQAKIFFSV

OR6K2

301

Q8NGY2
QKFALFKRIHKDGQV

RASSF5

316

Q8WWW0
FKRIHKDGQVLFQKL

RASSF5

321

Q8WWW0
KRVILKDLKHNDGNF

GUCY2C

511

P25092
EKSLLQKKLHHFFIG

ITPRIP

466

Q8IWB1
KLFDNHLGKSANFQK

MYH7

551

P12883
LRHKFFQKAKNKEFL

OXSR1

286

O95747
DAQLHEQFKKKLGFK

ANKAR

476

Q7Z5J8
FHFETLLKKTEIKGN

KANSL1L

646

A0AUZ9
QLLRQFGKLHTDKKQ

GNL2

296

Q13823
FHVKSGLQIKKNAII

MAPKAPK2

46

P49137
SKQHFVEKNKLTLGL

JHY

251

Q6NUN7
VHKEFKKALGANCIF

FXR2

156

P51116
KEENTIAFKHLFLKG

MCOLN3

91

Q8TDD5
KDKFQVAVNGKHTLL

LGALS8

111

O00214
KAFQKQEGFLKRLKH

MYO16

36

Q9Y6X6
QKFGAAILHIKKQNV

EXD1

86

Q8NHP7
KNKSLKHLFLGKNFN

CARMIL3

506

Q8ND23
KHLFLGKNFNVKAKT

CARMIL3

511

Q8ND23
KKIGILHENFQTLKA

DYNC1LI1

331

Q9Y6G9
LDTGEKLFHRIKKNF

CWF19L1

471

Q69YN2
RQGDFLHFLNVKKVK

KIAA1586

71

Q9HCI6
LKKHNERQFFLELVK

PDE11A

196

Q9HCR9
IKDGDFKNLKNLHAL

DCN

96

P07585
KQHFNDLKGTLGKLL

CRLF3

56

Q8IUI8
KQVFGHLEFLSGEKK

KNOP1

101

Q1ED39
FKDVDHLFQKKLAAQ

GBP3

371

Q9H0R5
RKNHGLVFVKDKIFA

KLHL7

471

Q8IXQ5
SAKKNLLKGHFRNFT

NALF2

181

O75949
LFGKDFHLIQKNKVR

MIER3

296

Q7Z3K6
HLLDKFIKEFLQPNK

OAS2

346

P29728
HFVTAKKKINGIFEQ

MFN2

31

O95140
HLFFLQVKKQILDEK

NF2

116

P35240
KLQEELNKVLGIKHF

HMMR

671

O75330
HKEAFLKKHNLKLGF

DLST

266

P36957
EHLNDKIKIKFGLAI

CHRNA5

66

P30532
LEAHVALKAGKLKFI

APOB

911

P04114
KQHLFVKEVKIDGQF

APOB

1476

P04114
NSQHFKALAEGKKAF

IFT46

271

Q9NQC8
GVLFCFNKRDLIKKH

IL6ST

636

P40189
KKLAAVHGKLQEAFT

DOCK6

1721

Q96HP0
KFKHAVNGFLKENKD

DUSP11

176

O75319
FKQELNHQFTKLLIK

DTX3L

321

Q8TDB6
LHLNQLEGNKEKFEK

CCDC18

741

Q5T9S5
NILEIFHLGFKKIKR

GJA9

226

P57773
NFQKLHELKKDLIGI

FARP1

736

Q9Y4F1
KNKTQIDGQLFLIKH

COG3

601

Q96JB2
LKECHKNHNILKFFG

CMC2

21

Q9NRP2
IGVSKDLNEQFKKHL

CUL1

511

Q13616
FNGEFKHKLFRIKIN

CUL4A

656

Q13619
KFHEQKLLKQVDFLN

IMP3

6

Q9NV31
KLKGLFTLFAGHLVK

HEATR1

1946

Q9H583
QFALAFHLISQKLIK

EPS15

281

P42566
CFQKFKHGFNLLAKL

EPS8

331

Q12929
IVESQINFHGKKLKL

DAZL

96

Q92904
HKKLFLVQLQEKALF

NUDT21

171

O43809
FQLQSGHKDKLKQAI

COG2

616

Q14746
IGAKNILVHSLNKFK

SBNO1

366

A3KN83
FEKKISHQILLKGAA

CFAP74

1461

Q9C0B2
NDDFKHKLFRIKINQ

CUL4B

811

Q13620
RKSNFIFDKLHKVGI

PANX2

316

Q96RD6
IERGAFNKLHKLKVL

SLITRK4

146

Q8IW52
NHLIQGLQKEAKEKF

STARD13

911

Q9Y3M8
IDKGTHVAFLNLQKK

TBC1D31

451

Q96DN5
GAKIQKSDFQKIAHL

TLR10

151

Q9BXR5
LKKKQEAGFALQHGL

SYNE2

2161

Q8WXH0
LQLQKSSGKIFKDFH

SYNJ2

756

O15056
IFKGKTFIFLNAKQH

NBN

221

O60934
AIQELNGKLFHKRKL

TDRD10

86

Q5VZ19
NGKLFHKRKLFVNTS

TDRD10

91

Q5VZ19
VAKKFLDAGHKLNFA

PDIA3

286

P30101
IHLQKGAFAKVKESQ

SNX33

486

Q8WV41
KHLLGEIRNLEKFKN

SPDL1

331

Q96EA4
EFKALKSLHEQGALK

ST8SIA2

351

Q92186
FLFQKKHVGRSKAQV

UBA2

61

Q9UBT2
GLKLFISHFLLKNAQ

NOM1

816

Q5C9Z4
LEGTQKAKKLFLQHI

ARHGAP35

311

Q9NRY4
KAKLEGHFKNQELRQ

RANBP6

806

O60518
LFAQKRGNVKHLVLF

SLC35A2

86

P78381
KPQHGFELNKIKFEA

TET1

2056

Q8NFU7
LIKHKKGIVNEQFLL

ACADVL

551

P49748
HFLKIDNQKFVRLKD

C12orf29

306

Q8N999
NFLEEKSILGNKKFH

ZNF132

271

P52740
ENEARGKLHIFNAKK

PHF6

221

Q8IWS0
KAGALAVKNFLVHKK

TIAM1

436

Q13009
EKHKKLFEGLKFFLN

PES1

321

O00541
NEQKHKAGFLDLKDF

TLN1

251

Q9Y490
IGNKDIKFKHLEEAF

STT3B

746

Q8TCJ2
GAQYKLLVTKLKHFQ

SIDT1

156

Q9NXL6
NFEPGKKNFLHLTDK

USP47

116

Q96K76
GKAFNQKSILIVHQK

ZNF585B

556

Q52M93
SFLNHKQEVEKLLGK

TTC14

546

Q96N46
EQKAKALKGQFNFDH

UCK2

71

Q9BZX2
KVLNKDGKAHFLQLR

RIOX2

111

Q8IUF8
ASIKDPHFLNFNKKL

PLCH1

1011

Q4KWH8
GKAFNQKSILIVHQK

ZNF585A

556

Q6P3V2
AAQKGFNKVVLKHLK

PRKDC

821

P78527
VIIDNFNKHKIKLGG

SCN7A

1191

Q01118
FNKHKIKLGGSNIFI

SCN7A

1196

Q01118
QALHFKINKVVVKAG

SH2D3C

261

Q8N5H7
SLKKLGLLFSKFNGH

TRPC5

841

Q9UL62
FGKKVLVVHFEDLKQ

WSCD2

471

Q2TBF2
KHLKGSIQLFEAKLD

TRANK1

836

O15050
GHLNSKLFLNEVAKK

TRIM8

326

Q9BZR9
VHGKVLFLQKQLAKV

MYO3B

296

Q8WXR4
EFRKLQGKLKNAHNI

PDE4DIP

1101

Q5VU43
FANLGILHVTKKKVF

NFKB1

136

P19838