Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionchromatin binding

PWWP2A MLLT3 MBTD1 CENPS ZNF609 REST EP300 BRD4 HNRNPU

3.19e-07739279GO:0003682
GeneOntologyMolecularFunctionmodification-dependent protein binding

PWWP2A MLLT3 MBTD1 EP300 BRD4

7.47e-06206275GO:0140030
GeneOntologyMolecularFunctionacetylation-dependent protein binding

MLLT3 EP300 BRD4

9.66e-0631273GO:0140033
GeneOntologyMolecularFunctionneuroligin family protein binding

NRXN3 NRXN1

1.76e-055272GO:0097109
GeneOntologyMolecularFunctiontranscription coregulator activity

C1D PA2G4 MTDH EP300 BRD4 HNRNPU

8.65e-05562276GO:0003712
GeneOntologyMolecularFunctionRNA polymerase II C-terminal domain binding

BRD4 HNRNPU

9.61e-0511272GO:0099122
GeneOntologyMolecularFunctionpromoter-specific chromatin binding

ZNF609 EP300 HNRNPU

1.88e-0483273GO:1990841
GeneOntologyMolecularFunctionhistone binding

PWWP2A MLLT3 MBTD1 BRD4

4.18e-04265274GO:0042393
GeneOntologyMolecularFunctiontranscription factor binding

C1D REST MTDH EP300 PCLO HNRNPU

4.23e-04753276GO:0008134
GeneOntologyMolecularFunctionlysine-acetylated histone binding

MLLT3 BRD4

7.48e-0430272GO:0070577
GeneOntologyMolecularFunctionNF-kappaB binding

MTDH EP300

1.08e-0336272GO:0051059
GeneOntologyMolecularFunctionRNA polymerase II complex binding

BRD4 HNRNPU

1.27e-0339272GO:0000993
GeneOntologyMolecularFunctionRNA polymerase core enzyme binding

BRD4 HNRNPU

1.68e-0345272GO:0043175
GeneOntologyMolecularFunctionmolecular adaptor activity

C1D MLLT3 PA2G4 MTDH EP300 BRD4 HNRNPU

1.74e-031356277GO:0060090
GeneOntologyMolecularFunctionRNA polymerase II-specific DNA-binding transcription factor binding

C1D REST MTDH EP300

2.25e-03417274GO:0061629
GeneOntologyMolecularFunctioncalcium channel regulator activity

NRXN3 NRXN1

2.41e-0354272GO:0005246
GeneOntologyMolecularFunctionpre-mRNA binding

EP300 HNRNPU

3.37e-0364272GO:0036002
GeneOntologyMolecularFunctionRNA polymerase binding

BRD4 HNRNPU

3.47e-0365272GO:0070063
GeneOntologyMolecularFunctiontranscription corepressor activity

C1D PA2G4 HNRNPU

3.55e-03229273GO:0003714
GeneOntologyMolecularFunctionbasal RNA polymerase II transcription machinery binding

BRD4 HNRNPU

3.58e-0366272GO:0001099
GeneOntologyMolecularFunctionbasal transcription machinery binding

BRD4 HNRNPU

3.58e-0366272GO:0001098
GeneOntologyMolecularFunctionprotein-macromolecule adaptor activity

C1D PA2G4 MTDH EP300 BRD4 HNRNPU

3.91e-031160276GO:0030674
GeneOntologyMolecularFunctionp53 binding

EP300 BRD4

4.84e-0377272GO:0002039
GeneOntologyMolecularFunctiondouble-stranded RNA binding

MTDH HNRNPU

4.96e-0378272GO:0003725
GeneOntologyMolecularFunctionmethylated histone binding

PWWP2A MBTD1

6.00e-0386272GO:0035064
GeneOntologyMolecularFunctionmethylation-dependent protein binding

PWWP2A MBTD1

6.27e-0388272GO:0140034
GeneOntologyMolecularFunctionDNA-binding transcription factor binding

C1D REST MTDH EP300

7.36e-03582274GO:0140297
GeneOntologyMolecularFunctiontranscription coactivator activity

MTDH EP300 BRD4

7.73e-03303273GO:0003713
GeneOntologyBiologicalProcesspresynaptic active zone assembly

NRXN1 PCLO

1.52e-055262GO:1904071
GeneOntologyBiologicalProcessneuronal signal transduction

NRXN1 MACO1

4.26e-058262GO:0023041
GeneOntologyBiologicalProcesspositive regulation of T-helper 17 cell lineage commitment

EP300 BRD4

4.26e-058262GO:2000330
GeneOntologyBiologicalProcessviral transcription

REST EP300 BRD4

5.24e-0558263GO:0019083
GeneOntologyBiologicalProcesspresynaptic active zone organization

NRXN1 PCLO

6.83e-0510262GO:1990709
GeneOntologyBiologicalProcessregulation of T-helper 17 cell lineage commitment

EP300 BRD4

8.35e-0511262GO:2000328
GeneOntologyBiologicalProcesschromatin organization

PWWP2A MLLT3 MBTD1 REST EP300 BRD4 HNRNPU

9.08e-05896267GO:0006325
GeneOntologyBiologicalProcesspositive regulation of T-helper 17 cell differentiation

EP300 BRD4

1.38e-0414262GO:2000321
GeneOntologyBiologicalProcessnegative regulation by host of viral transcription

REST BRD4

1.59e-0415262GO:0043922
GeneOntologyBiologicalProcessprotein-DNA complex organization

PWWP2A MLLT3 MBTD1 REST EP300 BRD4 HNRNPU

1.79e-04999267GO:0071824
GeneOntologyBiologicalProcessneuron cell-cell adhesion

NRXN3 NRXN1

1.81e-0416262GO:0007158
GeneOntologyBiologicalProcessmodulation by host of symbiont process

REST EP300 BRD4

2.01e-0491263GO:0051851
GeneOntologyBiologicalProcessregulation of transcription elongation by RNA polymerase II

PWWP2A BRD4 HNRNPU

2.14e-0493263GO:0034243
GeneOntologyBiologicalProcesspositive regulation of cell fate commitment

EP300 BRD4

2.31e-0418262GO:0010455
GeneOntologyBiologicalProcessregulation of DNA-templated transcription elongation

PWWP2A BRD4 HNRNPU

3.06e-04105263GO:0032784
GeneOntologyBiologicalProcessviral gene expression

REST EP300 BRD4

3.42e-04109263GO:0019080
GeneOntologyBiologicalProcessT-helper 17 cell lineage commitment

EP300 BRD4

3.48e-0422262GO:0072540
GeneOntologyBiologicalProcesssynaptic vesicle clustering

NRXN1 PCLO

3.48e-0422262GO:0097091
GeneOntologyBiologicalProcesspositive regulation of T-helper 17 type immune response

EP300 BRD4

3.80e-0423262GO:2000318
GeneOntologyBiologicalProcessprotein-containing complex localization

RALB NRXN3 NRXN1 HNRNPU

3.82e-04278264GO:0031503
GeneOntologyBiologicalProcessregulation of organelle assembly

RALB NRXN1 FEZ2 HNRNPU

3.93e-04280264GO:1902115
GeneOntologyBiologicalProcessorganelle assembly

BCCIP RALB NRXN3 NRXN1 FEZ2 EP300 HNRNPU

3.98e-041138267GO:0070925
GeneOntologyBiologicalProcessprotein localization to synapse

NRXN3 NRXN1 PCLO

4.00e-04115263GO:0035418
GeneOntologyBiologicalProcessvocalization behavior

NRXN3 NRXN1

4.15e-0424262GO:0071625
GeneOntologyBiologicalProcesstrans-synaptic signaling, modulating synaptic transmission

NRXN3 NRXN1

4.87e-0426262GO:0099550
GeneOntologyBiologicalProcessT-helper cell lineage commitment

EP300 BRD4

5.26e-0427262GO:0002295
GeneOntologyBiologicalProcesstranscription elongation by RNA polymerase II

PWWP2A BRD4 HNRNPU

5.34e-04127263GO:0006368
GeneOntologyBiologicalProcessbiological process involved in interaction with symbiont

REST EP300 BRD4

6.39e-04135263GO:0051702
GeneOntologyBiologicalProcessCD4-positive, alpha-beta T cell lineage commitment

EP300 BRD4

6.95e-0431262GO:0043373
GeneOntologyBiologicalProcesspositive regulation of T-helper cell differentiation

EP300 BRD4

6.95e-0431262GO:0045624
GeneOntologyBiologicalProcesspositive regulation of T cell differentiation

ZNF609 EP300 BRD4

7.70e-04144263GO:0045582
GeneOntologyBiologicalProcessDNA-templated transcription elongation

PWWP2A BRD4 HNRNPU

7.70e-04144263GO:0006354
GeneOntologyBiologicalProcessalpha-beta T cell lineage commitment

EP300 BRD4

7.88e-0433262GO:0002363
GeneOntologyBiologicalProcessnegative regulation of stem cell differentiation

REST HNRNPU

7.88e-0433262GO:2000737
GeneOntologyBiologicalProcessregulation of T-helper 17 cell differentiation

EP300 BRD4

7.88e-0433262GO:2000319
GeneOntologyBiologicalProcessprotein localization to cell junction

NRXN3 NRXN1 PCLO

8.34e-04148263GO:1902414
GeneOntologyBiologicalProcessnegative regulation of miRNA metabolic process

REST EP300

8.36e-0434262GO:2000629
GeneOntologyBiologicalProcesspostsynaptic density assembly

NRXN3 NRXN1

8.36e-0434262GO:0097107
GeneOntologyBiologicalProcessCD4-positive or CD8-positive, alpha-beta T cell lineage commitment

EP300 BRD4

8.86e-0435262GO:0043369
GeneOntologyBiologicalProcessDNA damage response

BCCIP MBTD1 CENPS KIN EP300 BRD4

1.03e-03959266GO:0006974
GeneOntologyBiologicalProcessresponse to glucocorticoid

REST EP300 HNRNPU

1.04e-03160263GO:0051384
GeneOntologyBiologicalProcesspositive regulation of lymphocyte differentiation

ZNF609 EP300 BRD4

1.08e-03162263GO:0045621
GeneOntologyBiologicalProcessmaintenance of synapse structure

NRXN1 PCLO

1.16e-0340262GO:0099558
GeneOntologyBiologicalProcessregulation of chromatin organization

MLLT3 HNRNPU

1.16e-0340262GO:1902275
GeneOntologyBiologicalProcesspositive regulation of binding

RALB EP300 BRD4

1.24e-03170263GO:0051099
GeneOntologyBiologicalProcessT cell lineage commitment

EP300 BRD4

1.28e-0342262GO:0002360
GeneOntologyBiologicalProcessnegative regulation of DNA-templated transcription

C1D MBTD1 REST PA2G4 MTDH EP300 HNRNPU

1.36e-031399267GO:0045892
GeneOntologyBiologicalProcesspostsynaptic specialization assembly

NRXN3 NRXN1

1.40e-0344262GO:0098698
GeneOntologyBiologicalProcessregulation of binding

RALB REST EP300 BRD4

1.43e-03396264GO:0051098
GeneOntologyBiologicalProcessnegative regulation of RNA biosynthetic process

C1D MBTD1 REST PA2G4 MTDH EP300 HNRNPU

1.44e-031413267GO:1902679
GeneOntologyBiologicalProcesspositive regulation of CD4-positive, alpha-beta T cell differentiation

EP300 BRD4

1.46e-0345262GO:0043372
GeneOntologyBiologicalProcessregulation of autophagy

RALB FEZ2 MTDH EP300

1.49e-03400264GO:0010506
GeneOntologyBiologicalProcessexcitatory synapse assembly

NRXN3 NRXN1

1.53e-0346262GO:1904861
GeneOntologyBiologicalProcesspositive regulation of molecular function

RALB REST NRXN1 MTDH EP300 BRD4 HNRNPU

1.55e-031430267GO:0044093
GeneOntologyBiologicalProcessresponse to corticosteroid

REST EP300 HNRNPU

1.59e-03185263GO:0031960
GeneOntologyBiologicalProcessT-helper 17 cell differentiation

EP300 BRD4

1.60e-0347262GO:0072539
GeneOntologyBiologicalProcessregulation of T-helper 17 type immune response

EP300 BRD4

1.60e-0347262GO:2000316
GeneOntologyBiologicalProcessorganelle localization

BCCIP RALB NRXN1 PCLO HNRNPU

1.64e-03703265GO:0051640
GeneOntologyBiologicalProcesssecretion by cell

RALB NRXN3 REST NRXN1 EP300 PCLO

1.76e-031064266GO:0032940
GeneOntologyBiologicalProcessregulation of autophagosome assembly

RALB FEZ2

1.80e-0350262GO:2000785
GeneOntologyBiologicalProcesssignal release from synapse

NRXN3 NRXN1 PCLO

1.84e-03195263GO:0099643
GeneOntologyBiologicalProcessneurotransmitter secretion

NRXN3 NRXN1 PCLO

1.84e-03195263GO:0007269
GeneOntologyBiologicalProcesspositive T cell selection

EP300 BRD4

2.02e-0353262GO:0043368
GeneOntologyBiologicalProcessregulation of cell fate commitment

EP300 BRD4

2.02e-0353262GO:0010453
GeneOntologyBiologicalProcesschromatin remodeling

PWWP2A REST EP300 BRD4 HNRNPU

2.07e-03741265GO:0006338
GeneOntologyBiologicalProcesspositive regulation of transcription elongation by RNA polymerase II

PWWP2A BRD4

2.10e-0354262GO:0032968
GeneOntologyBiologicalProcesscell morphogenesis involved in neuron differentiation

NRXN3 REST NRXN1 FEZ2 EP300

2.16e-03748265GO:0048667
GeneOntologyBiologicalProcessresponse to dexamethasone

EP300 HNRNPU

2.18e-0355262GO:0071548
GeneOntologyBiologicalProcessregulation of T-helper cell differentiation

EP300 BRD4

2.34e-0357262GO:0045622
GeneOntologyBiologicalProcesspostsynaptic density organization

NRXN3 NRXN1

2.42e-0358262GO:0097106
GeneOntologyBiologicalProcesspositive regulation of CD4-positive, alpha-beta T cell activation

EP300 BRD4

2.42e-0358262GO:2000516
GeneOntologyBiologicalProcessregulation of alternative mRNA splicing, via spliceosome

REST HNRNPU

2.50e-0359262GO:0000381
GeneOntologyBiologicalProcesspositive regulation of cell differentiation

ZNF609 REST PA2G4 EP300 BRD4 HNRNPU

2.50e-031141266GO:0045597
GeneOntologyBiologicalProcesschromosome segregation

BCCIP CENPS BRD4 HNRNPU

2.57e-03465264GO:0007059
GeneOntologyBiologicalProcesspresynapse assembly

NRXN1 PCLO

2.59e-0360262GO:0099054
GeneOntologyBiologicalProcesscardiocyte differentiation

REST EP300 HNRNPU

2.63e-03221263GO:0035051
GeneOntologyBiologicalProcessexport from cell

RALB NRXN3 REST NRXN1 EP300 PCLO

2.64e-031153266GO:0140352
GeneOntologyBiologicalProcessregulation of vacuole organization

RALB FEZ2

2.67e-0361262GO:0044088
GeneOntologyBiologicalProcesspositive regulation of DNA-templated transcription, elongation

PWWP2A BRD4

2.76e-0362262GO:0032786
GeneOntologyBiologicalProcessregulation of T cell differentiation

ZNF609 EP300 BRD4

2.80e-03226263GO:0045580
GeneOntologyBiologicalProcessT-helper 17 type immune response

EP300 BRD4

2.94e-0364262GO:0072538
GeneOntologyCellularComponentnuclear cyclin-dependent protein kinase holoenzyme complex

BCCIP BRD4

2.43e-0418272GO:0019908
GeneOntologyCellularComponentinhibitory synapse

NRXN1 PCLO

7.30e-0431272GO:0060077
GeneOntologyCellularComponentpresynaptic active zone

NRXN3 NRXN1 PCLO

7.80e-04141273GO:0048786
GeneOntologyCellularComponentGABA-ergic synapse

NRXN3 NRXN1 PCLO

1.21e-03164273GO:0098982
DomainSyndecan/Neurexin_dom

NRXN3 NRXN1

4.21e-057272IPR027789
DomainSyndecan

NRXN3 NRXN1

4.21e-057272PF01034
DomainNeurexin-like

NRXN3 NRXN1

1.81e-0414272IPR003585
Domain4.1m

NRXN3 NRXN1

1.81e-0414272SM00294
DomainBromodomain_CS

EP300 BRD4

6.40e-0426272IPR018359
DomainBROMODOMAIN_1

EP300 BRD4

1.30e-0337272PS00633
DomainLAM_G_DOMAIN

NRXN3 NRXN1

1.37e-0338272PS50025
DomainBromodomain

EP300 BRD4

1.37e-0338272PF00439
DomainLaminin_G_2

NRXN3 NRXN1

1.52e-0340272PF02210
DomainBROMODOMAIN_2

EP300 BRD4

1.59e-0341272PS50014
DomainBROMO

EP300 BRD4

1.67e-0342272SM00297
DomainBromodomain

EP300 BRD4

1.67e-0342272IPR001487
Domain-

EP300 BRD4

1.67e-03422721.20.920.10
DomainLamG

NRXN3 NRXN1

1.83e-0344272SM00282
DomainLaminin_G

NRXN3 NRXN1

3.16e-0358272IPR001791
DomainConA-like_dom

NRXN3 NRXN1 HNRNPU

3.78e-03219273IPR013320
Domain-

NRXN3 NRXN1

8.27e-03952722.60.120.200
DomainASX_HYDROXYL

NRXN3 NRXN1

9.13e-03100272PS00010
DomainEGF-type_Asp/Asn_hydroxyl_site

NRXN3 NRXN1

1.02e-02106272IPR000152
DomainEGF

NRXN3 NRXN1

1.42e-02126272PF00008
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

PWWP2A MBTD1 CENPS ISG20L2 ZNF609 REST MTDH EP300 MACO1 BRD4 KTN1 HNRNPU

6.93e-111294271230804502
Pubmed

Association of a polymorphism in the NRXN3 gene with the degree of smoking in schizophrenia: a preliminary study.

NRXN3 NRXN1

5.80e-07227219658047
Pubmed

Neurexin-3 subsynaptic densities are spatially distinct from Neurexin-1 and essential for excitatory synapse nanoscale organization in the hippocampus.

NRXN3 NRXN1

5.80e-07227237543682
Pubmed

Neurexin I alpha is a major alpha-latrotoxin receptor that cooperates in alpha-latrotoxin action.

NRXN3 NRXN1

5.80e-0722729430716
Pubmed

LYRIC/AEG-1 overexpression modulates BCCIPalpha protein levels in prostate tumor cells.

BCCIP MTDH

5.80e-07227218440304
Pubmed

Scaffold/matrix attachment region elements interact with a p300-scaffold attachment factor A complex and are bound by acetylated nucleosomes.

EP300 HNRNPU

5.80e-07227211909954
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

CYLC1 RALB ISG20L2 NRXN3 NRXN1 MTDH PCLO KTN1 HNRNPU

8.41e-07144227935575683
Pubmed

The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.

ISG20L2 KIN PA2G4 MTDH FKBP3 KTN1 HNRNPU

1.39e-0675927735915203
Pubmed

Endogenous β-neurexins on axons and within synapses show regulated dynamic behavior.

NRXN3 NRXN1

1.74e-06327234133920
Pubmed

Conditional Knockout of Neurexins Alters the Contribution of Calcium Channel Subtypes to Presynaptic Ca2+ Influx.

NRXN3 NRXN1

1.74e-06327238891114
Pubmed

Structure and evolution of neurexin genes: insight into the mechanism of alternative splicing.

NRXN3 NRXN1

1.74e-06327212036300
Pubmed

β-Neurexins Control Neural Circuits by Regulating Synaptic Endocannabinoid Signaling.

NRXN3 NRXN1

1.74e-06327226213384
Pubmed

Neurexin gene family variants as risk factors for autism spectrum disorder.

NRXN3 NRXN1

1.74e-06327229045040
Pubmed

Alternative Splicing of Presynaptic Neurexins Differentially Controls Postsynaptic NMDA and AMPA Receptor Responses.

NRXN3 NRXN1

1.74e-06327231005376
Pubmed

Structural and functional characterization of the IgSF21-neurexin2α complex and its related signaling pathways in the regulation of inhibitory synapse organization.

NRXN3 NRXN1

1.74e-06327238571813
Pubmed

Deletion of β-Neurexins in Mice Alters the Distribution of Dense-Core Vesicles in Presynapses of Hippocampal and Cerebellar Neurons.

NRXN3 NRXN1

1.74e-06327235173587
Pubmed

Brd4-p300 inhibition downregulates Nox4 and accelerates lung fibrosis resolution in aged mice.

EP300 BRD4

1.74e-06327232544088
Pubmed

The within-subject application of diffusion tensor MRI and CLARITY reveals brain structural changes in Nrxn2 deletion mice.

NRXN3 NRXN1

1.74e-06327230858964
Pubmed

Neurexins are differentially expressed in the embryonic nervous system of mice.

NRXN3 NRXN1

1.74e-0632727722633
Pubmed

Regulated Dynamic Trafficking of Neurexins Inside and Outside of Synaptic Terminals.

NRXN3 NRXN1

1.74e-06327226446217
Pubmed

Neurexins 1-3 Each Have a Distinct Pattern of Expression in the Early Developing Human Cerebral Cortex.

NRXN3 NRXN1

1.74e-06327228013231
Pubmed

Analysis of the human neurexin genes: alternative splicing and the generation of protein diversity.

NRXN3 NRXN1

1.74e-06327211944992
Pubmed

alpha-Neurexins are required for efficient transmitter release and synaptic homeostasis at the mouse neuromuscular junction.

NRXN3 NRXN1

1.74e-06327216406382
Pubmed

Alternative splicing of neurexins 1-3 is modulated by neuroinflammation in the prefrontal cortex of a murine model of multiple sclerosis.

NRXN3 NRXN1

1.74e-06327233058888
Pubmed

Important contribution of alpha-neurexins to Ca2+-triggered exocytosis of secretory granules.

NRXN3 NRXN1

1.74e-06327217035546
Pubmed

Neurexins: three genes and 1001 products.

NRXN3 NRXN1

1.74e-0632729448462
Pubmed

Deletion of α-neurexin II results in autism-related behaviors in mice.

NRXN3 NRXN1

1.74e-06327225423136
Pubmed

Ketamine Restores Thalamic-Prefrontal Cortex Functional Connectivity in a Mouse Model of Neurodevelopmental Disorder-Associated 2p16.3 Deletion.

NRXN3 NRXN1

1.74e-06327231812984
Pubmed

Promoter-bound p300 complexes facilitate post-mitotic transmission of transcriptional memory.

EP300 BRD4

1.74e-06327224945803
Pubmed

Astrocyte Elevated Gene 1 Interacts with Acetyltransferase p300 and c-Jun To Promote Tumor Aggressiveness.

MTDH EP300

1.74e-06327227956703
Pubmed

Oncogenesis by sequestration of CBP/p300 in transcriptionally inactive hyperacetylated chromatin domains.

EP300 BRD4

1.74e-06327220676058
Pubmed

KIF15 promotes human glioblastoma progression under the synergistic transactivation of REST and P300.

REST EP300

1.74e-06327239430242
Pubmed

Distinct Roles of Brd2 and Brd4 in Potentiating the Transcriptional Program for Th17 Cell Differentiation.

EP300 BRD4

1.74e-06327228262505
Pubmed

Postsynaptic N-methyl-D-aspartate receptor function requires alpha-neurexins.

NRXN3 NRXN1

3.48e-06427214983056
Pubmed

CASK: a novel dlg/PSD95 homolog with an N-terminal calmodulin-dependent protein kinase domain identified by interaction with neurexins.

NRXN3 NRXN1

3.48e-0642728786425
Pubmed

Brd4's Bromodomains Mediate Histone H3 Acetylation and Chromatin Remodeling in Pluripotent Cells through P300 and Brg1.

EP300 BRD4

3.48e-06427230428346
Pubmed

NSD3-NUT fusion oncoprotein in NUT midline carcinoma: implications for a novel oncogenic mechanism.

EP300 BRD4

3.48e-06427224875858
Pubmed

Deletion of alpha-neurexins does not cause a major impairment of axonal pathfinding or synapse formation.

NRXN3 NRXN1

3.48e-06427217347997
Pubmed

Neurexins cluster Ca2+ channels within the presynaptic active zone.

NRXN3 NRXN1

3.48e-06427232134527
Pubmed

Deorphanizing FAM19A proteins as pan-neurexin ligands with an unusual biosynthetic binding mechanism.

NRXN3 NRXN1

3.48e-06427232706374
Pubmed

Binding of the SARS-CoV-2 envelope E protein to human BRD4 is essential for infection.

EP300 BRD4

3.48e-06427235716662
Pubmed

Neurexins play a crucial role in cerebellar granule cell survival by organizing autocrine machinery for neurotrophins.

NRXN3 NRXN1

3.48e-06427235385735
Pubmed

Neurexins regulate presynaptic GABAB-receptors at central synapses.

NRXN3 NRXN1

3.48e-06427233888718
Pubmed

TNRC6 proteins modulate hepatitis C virus replication by spatially regulating the binding of miR-122/Ago2 complexes to viral RNA.

PA2G4 MTDH FKBP3 KTN1 HNRNPU

4.17e-0631727530997501
Pubmed

Conditional Deletion of All Neurexins Defines Diversity of Essential Synaptic Organizer Functions for Neurexins.

NRXN3 NRXN1

5.80e-06527228472659
Pubmed

Concerted roles of LRRTM1 and SynCAM 1 in organizing prefrontal cortex synapses and cognitive functions.

NRXN3 NRXN1

5.80e-06527236709330
Pubmed

Neuroligins and neurexins link synaptic function to cognitive disease.

NRXN3 NRXN1

5.80e-06527218923512
Pubmed

Trans-synaptic interaction of GluRdelta2 and Neurexin through Cbln1 mediates synapse formation in the cerebellum.

NRXN3 NRXN1

5.80e-06527220537373
Pubmed

Distinct neurexin-cerebellin complexes control AMPA- and NMDA-receptor responses in a circuit-dependent manner.

NRXN3 NRXN1

5.80e-06527236205393
Pubmed

Acetylcholinesterase-transgenic mice display embryonic modulations in spinal cord choline acetyltransferase and neurexin Ibeta gene expression followed by late-onset neuromotor deterioration.

NRXN3 NRXN1

5.80e-0652729223334
Pubmed

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.

ZNF609 PA2G4 MTDH FKBP3 BRD4 KTN1 HNRNPU

6.28e-0695427736373674
Pubmed

The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1.

MLLT3 MBTD1 REST EP300

6.47e-0615727430186101
Pubmed

Structures, alternative splicing, and neurexin binding of multiple neuroligins.

NRXN3 NRXN1

8.69e-0662728576240
Pubmed

Presynaptic α2δ-2 Calcium Channel Subunits Regulate Postsynaptic GABAA Receptor Abundance and Axonal Wiring.

NRXN3 NRXN1

8.69e-06627230683685
Pubmed

Alpha-neurexins couple Ca2+ channels to synaptic vesicle exocytosis.

NRXN3 NRXN1

8.69e-06627212827191
Pubmed

Synapse formation regulated by protein tyrosine phosphatase receptor T through interaction with cell adhesion molecules and Fyn.

NRXN3 NRXN1

8.69e-06627219816407
Pubmed

Glycosylation of Cblns attenuates their receptor binding.

NRXN3 NRXN1

1.22e-05727229782851
Pubmed

Neurexophilin binding to alpha-neurexins. A single LNS domain functions as an independently folding ligand-binding unit.

NRXN3 NRXN1

1.22e-0572729856994
Pubmed

Identification and functional characterization of transcriptional activators in human cells.

MBTD1 ZNF609 EP300 BRD4 PCLO

1.26e-0539827535016035
Pubmed

GluD1 is a signal transduction device disguised as an ionotropic receptor.

NRXN3 NRXN1

1.62e-05827234135511
Pubmed

Neuroligin-1 Signaling Controls LTP and NMDA Receptors by Distinct Molecular Pathways.

NRXN3 NRXN1

1.62e-05827230871858
Pubmed

The methyltransferase SMYD3 mediates the recruitment of transcriptional cofactors at the myostatin and c-Met genes and regulates skeletal muscle atrophy.

EP300 BRD4

1.62e-05827223752591
Pubmed

Combinatorial expression of neurexins and LAR-type phosphotyrosine phosphatase receptors instructs assembly of a cerebellar circuit.

NRXN3 NRXN1

1.62e-05827237591863
Pubmed

An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.

C1D BCCIP ZNF609 KIN MACO1 KTN1

1.74e-0573327634672954
Pubmed

Reduced expression of neuropeptide genes in a genome-wide screen of a secretion-deficient mouse.

NRXN3 NRXN1 PCLO

1.93e-056727316987237
Pubmed

PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor.

NRXN3 NRXN1

2.08e-0592729707552
Pubmed

Molecular self-avoidance in synaptic neurexin complexes.

NRXN3 NRXN1

2.08e-05927234919427
Pubmed

Human ALKBH4 interacts with proteins associated with transcription.

MLLT3 EP300

2.60e-051027223145062
Pubmed

HIV-1 Vif promotes the G₁- to S-phase cell-cycle transition.

BRD4 HNRNPU

2.60e-051027221149631
Pubmed

Wnt regulation: exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex.

ISG20L2 PA2G4 MTDH FKBP3 KTN1 HNRNPU

3.03e-0580927632129710
Pubmed

SPARCL1 Promotes Excitatory But Not Inhibitory Synapse Formation and Function Independent of Neurexins and Neuroligins.

NRXN3 NRXN1

3.18e-051127232973045
Pubmed

The contribution of rare and common variants in 30 genes to risk nicotine dependence.

NRXN3 NRXN1

5.25e-051427225450229
Pubmed

HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.

C1D BCCIP ISG20L2 PA2G4 MTDH FKBP3 KTN1

6.46e-05137127736244648
Pubmed

Cohesin regulates tissue-specific expression by stabilizing highly occupied cis-regulatory modules.

REST EP300

6.92e-051627222780989
Pubmed

Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

NRXN3 NRXN1 PCLO

7.42e-051052739628581
Pubmed

LINC00240 in the 6p22.1 risk locus promotes gastric cancer progression through USP10-mediated DDX21 stabilization.

PA2G4 KTN1

7.84e-051727237072811
Pubmed

MEF2C regulates cortical inhibitory and excitatory synapses and behaviors relevant to neurodevelopmental disorders.

NRXN3 NRXN1

7.84e-051727227779093
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

BCCIP PA2G4 MTDH FKBP3 PCLO KTN1 HNRNPU

8.24e-05142527730948266
Pubmed

The leukemogenic AF4-MLL fusion protein causes P-TEFb kinase activation and altered epigenetic signatures.

MLLT3 BRD4

8.81e-051827221030982
Pubmed

Acetylation-regulated interaction between p53 and SET reveals a widespread regulatory mode.

EP300 BRD4

9.84e-051927227626385
Pubmed

Lost in transcription: molecular mechanisms that control HIV latency.

MLLT3 BRD4

9.84e-051927223518577
Pubmed

STING-Mediated IFI16 Degradation Negatively Controls Type I Interferon Production.

ISG20L2 MTDH KTN1 HNRNPU

9.95e-0531627431665637
Pubmed

Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.

BCCIP PA2G4 MTDH EP300 HNRNPU

1.32e-0465327533742100
Pubmed

Cbln1 regulates axon growth and guidance in multiple neural regions.

NRXN3 NRXN1

1.33e-042227236395107
Pubmed

Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST.

NRXN3 REST NRXN1

1.34e-0412827330995482
Pubmed

New insights into the control of HIV-1 transcription: when Tat meets the 7SK snRNP and super elongation complex (SEC).

MLLT3 BRD4

1.45e-042327221360054
Pubmed

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

KIN NRXN1 MTDH FKBP3 BRD4 HNRNPU

1.51e-04108227638697112
Pubmed

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.

ZNF609 PA2G4 FKBP3 EP300 BRD4 HNRNPU

1.68e-04110327634189442
Pubmed

Matrix-screening reveals a vast potential for direct protein-protein interactions among RNA binding proteins.

FEZ2 PA2G4 FKBP3 BRD4 HNRNPU

2.11e-0472327534133714
Pubmed

A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.

ZNF609 KIN MTDH FKBP3 KTN1

2.13e-0472427536232890
Pubmed

Prohibitin 1 regulates tumor cell apoptosis via the interaction with X-linked inhibitor of apoptosis protein.

KIN PA2G4 MTDH KTN1 HNRNPU

2.14e-0472527527025967
Pubmed

Differential expression of paralog RNA binding proteins establishes a dynamic splicing program required for normal cerebral cortex development.

NRXN3 NRXN1

2.17e-042827238324473
Pubmed

Characterizing ZC3H18, a Multi-domain Protein at the Interface of RNA Production and Destruction Decisions.

C1D ISG20L2 PA2G4 MTDH HNRNPU

2.23e-0473127529298432
Pubmed

Therapeutic targeting of the USP2-E2F4 axis inhibits autophagic machinery essential for zinc homeostasis in cancer progression.

PA2G4 FKBP3 BRD4 KTN1

2.52e-0440327435253629
Pubmed

miR-218 Promotes Dopaminergic Differentiation and Controls Neuron Excitability and Neurotransmitter Release through the Regulation of a Synaptic-Related Genes Network.

NRXN1 PCLO

2.66e-043127237816598
Pubmed

Exploring an Alternative Cysteine-Reactive Chemistry to Enable Proteome-Wide PPI Analysis by Cross-Linking Mass Spectrometry.

BCCIP PA2G4 KTN1 HNRNPU

2.72e-0441127436652389
Pubmed

Comparative Proteomics and Interactome Analysis of the SARS-CoV-2 Nucleocapsid Protein in Human and Bat Cell Lines.

PA2G4 MTDH HNRNPU

2.97e-0416827339066279
Pubmed

Multiplexed barcoded CRISPR-Cas9 screening enabled by CombiGEM.

EP300 BRD4

3.02e-043327226864203
Pubmed

Human variation in alcohol response is influenced by variation in neuronal signaling genes.

NRXN1 FEZ2 PCLO

3.13e-0417127320201926
Pubmed

DBC1, p300, HDAC3, and Siah1 coordinately regulate ELL stability and function for expression of its target genes.

MLLT3 EP300

3.21e-043427232152128
InteractionRPL19 interactions

BCCIP ISG20L2 REST KIN PA2G4 MTDH FKBP3 BRD4 KTN1 HNRNPU

4.89e-096382710int:RPL19
InteractionBCCIP interactions

BCCIP MTDH EP300 BRD4 HNRNPU

1.89e-06157275int:BCCIP
InteractionRBM8A interactions

BCCIP PA2G4 MTDH FKBP3 BRD4 KTN1 HNRNPU

2.22e-06473277int:RBM8A
InteractionH2BC12 interactions

CYLC1 PWWP2A RALB MTDH BRD4 PCLO

3.54e-06322276int:H2BC12
InteractionPSPC1 interactions

ISG20L2 PA2G4 MTDH EP300 BRD4 KTN1 HNRNPU

3.89e-06515277int:PSPC1
InteractionRPL4 interactions

BCCIP REST KIN PA2G4 MTDH BRD4 KTN1 HNRNPU

4.81e-06764278int:RPL4
InteractionRALY interactions

BCCIP REST MTDH EP300 BRD4 HNRNPU

6.30e-06356276int:RALY
InteractionPHB1 interactions

RALB KIN NRXN1 PA2G4 MTDH EP300 BRD4 KTN1 HNRNPU

9.43e-061123279int:PHB1
InteractionRTRAF interactions

FEZ2 FKBP3 EP300 BRD4 HNRNPU

1.03e-05222275int:RTRAF
InteractionHDAC2 interactions

PWWP2A ZNF609 REST PA2G4 FKBP3 EP300 BRD4 HNRNPU

1.20e-05865278int:HDAC2
InteractionRPL12 interactions

C1D REST KIN PA2G4 BRD4 HNRNPU

1.26e-05402276int:RPL12
InteractionMRGBP interactions

MBTD1 REST BRD4 HNRNPU

1.29e-05109274int:MRGBP
InteractionHMGA1 interactions

PWWP2A REST PA2G4 FKBP3 BRD4 PCLO

1.59e-05419276int:HMGA1
InteractionNELFB interactions

PA2G4 FKBP3 BRD4 HNRNPU

1.60e-05115274int:NELFB
InteractionNPM1 interactions

BCCIP ISG20L2 REST PA2G4 MTDH EP300 BRD4 KTN1 HNRNPU

1.62e-051201279int:NPM1
InteractionFBXW2 interactions

REST MTDH EP300

1.75e-0538273int:FBXW2
InteractionMTREX interactions

C1D MTDH EP300 BRD4 HNRNPU

2.28e-05262275int:MTREX
InteractionRPL18A interactions

REST KIN PA2G4 MTDH BRD4 HNRNPU

2.29e-05447276int:RPL18A
InteractionCTCF interactions

PA2G4 MTDH EP300 BRD4 KTN1 HNRNPU

2.73e-05461276int:CTCF
InteractionH2BC21 interactions

CYLC1 PWWP2A REST EP300 BRD4 PCLO HNRNPU

2.76e-05696277int:H2BC21
InteractionLOC102724334 interactions

CYLC1 C1D PWWP2A PCLO

2.91e-05134274int:LOC102724334
InteractionASCL1 interactions

REST EP300 BRD4

2.93e-0545273int:ASCL1
InteractionHECTD1 interactions

ISG20L2 KIN PA2G4 MTDH FKBP3 EP300 KTN1 HNRNPU

3.04e-05984278int:HECTD1
InteractionRPL3 interactions

ISG20L2 REST KIN PA2G4 MTDH BRD4 HNRNPU

3.49e-05722277int:RPL3
InteractionMCM6 interactions

MLLT3 MTDH EP300 BRD4 HNRNPU

3.53e-05287275int:MCM6
InteractionSUDS3 interactions

PWWP2A ZNF609 EP300 BRD4

3.56e-05141274int:SUDS3
InteractionH2BC15 interactions

CYLC1 BCCIP REST PCLO

3.86e-05144274int:H2BC15
InteractionRPL18 interactions

REST KIN PA2G4 MTDH BRD4 HNRNPU

4.91e-05512276int:RPL18
InteractionTOP2A interactions

CYLC1 MTDH EP300 BRD4 KTN1 HNRNPU

5.35e-05520276int:TOP2A
InteractionEMD interactions

BCCIP MTDH EP300 MACO1 BRD4 KTN1 HNRNPU

6.14e-05789277int:EMD
InteractionSRP72 interactions

PA2G4 MTDH EP300 KTN1 HNRNPU

7.16e-05333275int:SRP72
InteractionABCA12 interactions

MTDH BRD4

7.73e-0510272int:ABCA12
InteractionTULP3 interactions

BCCIP RALB MLLT3 MBTD1 EP300

8.57e-05346275int:TULP3
InteractionSND1 interactions

PA2G4 MTDH EP300 BRD4 HNRNPU

8.69e-05347275int:SND1
InteractionSAP130 interactions

BCCIP PWWP2A BRD4 HNRNPU

9.40e-05181274int:SAP130
InteractionH2BC26 interactions

MBTD1 REST BRD4 PCLO

9.81e-05183274int:H2BC26
InteractionRPL21 interactions

REST NRXN1 PA2G4 BRD4 HNRNPU

9.93e-05357275int:RPL21
InteractionDDX47 interactions

REST EP300 BRD4 HNRNPU

1.04e-04186274int:DDX47
InteractionH2BC11 interactions

CYLC1 REST BRD4 PCLO

1.04e-04186274int:H2BC11
InteractionAPI5 interactions

ZNF609 EP300 BRD4 HNRNPU

1.09e-04188274int:API5
InteractionRNF2 interactions

MLLT3 MBTD1 REST MTDH BRD4 PCLO HNRNPU

1.10e-04866277int:RNF2
InteractionRPS6 interactions

BCCIP ISG20L2 REST PA2G4 BRD4 PCLO HNRNPU

1.17e-04874277int:RPS6
InteractionRPL5 interactions

REST PA2G4 MTDH BRD4 KTN1 HNRNPU

1.24e-04606276int:RPL5
InteractionSTMN1 interactions

NRXN1 FKBP3 EP300 BRD4

1.25e-04195274int:STMN1
InteractionTARS1 interactions

REST FKBP3 BRD4 HNRNPU

1.25e-04195274int:TARS1
InteractionSIN3A interactions

PWWP2A REST PA2G4 EP300 BRD4

1.33e-04380275int:SIN3A
InteractionMRTO4 interactions

ISG20L2 MTDH EP300 HNRNPU

1.38e-04200274int:MRTO4
InteractionABCF1 interactions

FKBP3 EP300 BRD4 HNRNPU

1.41e-04201274int:ABCF1
InteractionGNL2 interactions

C1D ISG20L2 MTDH BRD4 HNRNPU

1.43e-04386275int:GNL2
InteractionGRIA2 interactions

REST NRXN1 MTDH HNRNPU

1.46e-04203274int:GRIA2
InteractionPSIP1 interactions

REST MTDH EP300 BRD4

1.52e-04205274int:PSIP1
InteractionITGAL interactions

EP300 HNRNPU

1.56e-0414272int:ITGAL
InteractionELL interactions

MLLT3 EP300 HNRNPU

1.64e-0480273int:ELL
InteractionFBL interactions

REST MTDH FKBP3 BRD4 KTN1 HNRNPU

1.66e-04639276int:FBL
InteractionPCAT1 interactions

EP300 PCLO

1.80e-0415272int:PCAT1
InteractionCAPN1 interactions

BCCIP EP300 BRD4 KTN1

1.82e-04215274int:CAPN1
InteractionTAF15 interactions

ZNF609 REST EP300 BRD4 HNRNPU

1.85e-04408275int:TAF15
InteractionRPL11 interactions

REST PA2G4 MTDH BRD4 KTN1 HNRNPU

1.86e-04652276int:RPL11
InteractionMDM2 interactions

REST PA2G4 MTDH FKBP3 EP300 HNRNPU

1.95e-04658276int:MDM2
InteractionRPLP0 interactions

REST KIN PA2G4 MTDH BRD4 HNRNPU

1.98e-04660276int:RPLP0
InteractionDHX9 interactions

REST PA2G4 MTDH EP300 BRD4 HNRNPU

2.01e-04662276int:DHX9
InteractionALYREF interactions

REST KIN EP300 BRD4 HNRNPU

2.03e-04416275int:ALYREF
InteractionLINC00240 interactions

PA2G4 KTN1

2.05e-0416272int:LINC00240
InteractionERG interactions

ZNF609 EP300 BRD4 HNRNPU

2.10e-04223274int:ERG
InteractionKRT18 interactions

FKBP3 EP300 MACO1 BRD4 HNRNPU

2.10e-04419275int:KRT18
InteractionSRSF9 interactions

MBTD1 REST EP300 BRD4

2.13e-04224274int:SRSF9
InteractionRFC4 interactions

FKBP3 EP300 BRD4 HNRNPU

2.24e-04227274int:RFC4
InteractionDDX17 interactions

REST KIN EP300 BRD4 HNRNPU

2.27e-04426275int:DDX17
InteractionRPL27 interactions

REST PA2G4 EP300 BRD4 HNRNPU

2.39e-04431275int:RPL27
InteractionRERE interactions

ZNF609 REST EP300

2.57e-0493273int:RERE
InteractionSMC5 interactions

ZNF609 PA2G4 MTDH FKBP3 BRD4 KTN1 HNRNPU

2.69e-041000277int:SMC5
InteractionH2BC9 interactions

CYLC1 PWWP2A REST BRD4 PCLO

2.80e-04446275int:H2BC9
InteractionRACK1 interactions

ISG20L2 PA2G4 MTDH EP300 BRD4 KTN1

2.81e-04704276int:RACK1
InteractionSOX9 interactions

ZNF609 EP300 BRD4

2.91e-0497273int:SOX9
InteractionPAX4 interactions

NRXN3 HNRNPU

2.91e-0419272int:PAX4
InteractionIFI16 interactions

ISG20L2 MTDH EP300 BRD4 KTN1 HNRNPU

3.03e-04714276int:IFI16
InteractionSUB1 interactions

REST ARHGAP20 EP300 BRD4

3.10e-04247274int:SUB1
InteractionEIF2S2 interactions

PA2G4 MTDH BRD4 KTN1

3.10e-04247274int:EIF2S2
InteractionCBX8 interactions

MLLT3 EP300 BRD4 HNRNPU

3.19e-04249274int:CBX8
InteractionRPS16 interactions

REST PA2G4 MTDH BRD4 KTN1 HNRNPU

3.27e-04724276int:RPS16
InteractionEEF1G interactions

MTDH EP300 BRD4 KTN1 HNRNPU

3.33e-04463275int:EEF1G
InteractionRPS7 interactions

REST KIN NRXN1 BRD4 HNRNPU

3.43e-04466275int:RPS7
InteractionH1-0 interactions

PWWP2A REST BRD4 HNRNPU

3.55e-04256274int:H1-0
InteractionSYT4 interactions

REST NRXN1

3.57e-0421272int:SYT4
InteractionDDX50 interactions

MTDH EP300 BRD4 HNRNPU

3.60e-04257274int:DDX50
InteractionSF3A1 interactions

ARHGAP20 PA2G4 EP300 BRD4 HNRNPU

3.60e-04471275int:SF3A1
InteractionDHCR7 interactions

MTDH EP300 PCLO KTN1

3.65e-04258274int:DHCR7
InteractionHMGB2 interactions

BCCIP EP300 BRD4 KTN1

3.65e-04258274int:HMGB2
InteractionH2BC4 interactions

PWWP2A RALB MTDH BRD4

3.71e-04259274int:H2BC4
InteractionSRPK1 interactions

MTDH FKBP3 EP300 BRD4 HNRNPU

3.82e-04477275int:SRPK1
InteractionIRF2 interactions

PA2G4 MTDH EP300

3.88e-04107273int:IRF2
InteractionNLGN1 interactions

NRXN3 NRXN1

3.93e-0422272int:NLGN1
InteractionEIF3C interactions

EP300 BRD4 PCLO HNRNPU

3.93e-04263274int:EIF3C
InteractionYBX1 interactions

REST PA2G4 MTDH FKBP3 EP300 HNRNPU

4.00e-04752276int:YBX1
InteractionHNRNPA2B1 interactions

PA2G4 MTDH FKBP3 EP300 BRD4 HNRNPU

4.06e-04754276int:HNRNPA2B1
InteractionTMPO interactions

MTDH EP300 MACO1 BRD4 KTN1 HNRNPU

4.29e-04762276int:TMPO
InteractionCEBPB interactions

MLLT3 PA2G4 MTDH FKBP3 EP300 BRD4 KTN1 HNRNPU

4.39e-041443278int:CEBPB
InteractionRPL28 interactions

REST PA2G4 KIAA0232 BRD4 HNRNPU

4.48e-04494275int:RPL28
InteractionEFTUD2 interactions

RALB KIN PA2G4 MTDH FKBP3 BRD4 KTN1 HNRNPU

4.51e-041449278int:EFTUD2
InteractionSF3A2 interactions

REST EP300 BRD4 HNRNPU

4.52e-04273274int:SF3A2
CoexpressionLEE_BMP2_TARGETS_DN

BCCIP MLLT3 CENPS ISG20L2 ARHGAP20 PA2G4 FKBP3

2.75e-05904277M2325
CoexpressionLEE_BMP2_TARGETS_DN

BCCIP MLLT3 CENPS ISG20L2 ARHGAP20 PA2G4 FKBP3

3.12e-05922277MM1068
CoexpressionGSE12392_CD8A_POS_VS_NEG_SPLEEN_IFNB_KO_DC_DN

RALB MLLT3 FKBP3 BRD4

5.03e-05200274M7134
CoexpressionGSE39820_CTRL_VS_TGFBETA3_IL6_CD4_TCELL_UP

ISG20L2 MTDH FKBP3 HNRNPU

5.03e-05200274M5610
CoexpressionDIAZ_CHRONIC_MYELOGENOUS_LEUKEMIA_UP

C1D RALB MLLT3 CENPS REST FEZ2 FKBP3 KTN1

5.76e-051399278M535
CoexpressionSCHLOSSER_SERUM_RESPONSE_DN

C1D ISG20L2 KIN MTDH EP300 KTN1

6.77e-05705276M1410
CoexpressionSCHAEFFER_PROSTATE_DEVELOPMENT_6HR_DN

MLLT3 REST MACO1 BRD4 HNRNPU

1.03e-04467275M1347
CoexpressionSCHAEFFER_PROSTATE_DEVELOPMENT_6HR_DN

MLLT3 REST MACO1 BRD4 HNRNPU

1.21e-04484275MM999
CoexpressionAtlasFacebaseRNAseq_e8.5_Hind Brain Neural Epithelium_top-relative-expression-ranked_2500_k-means-cluster#3

MLLT3 FKBP3 MACO1 PCLO KTN1 HNRNPU

3.61e-05532266Facebase_RNAseq_e8.5_Hind Brain Neural Epithelium_2500_K3
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Overlying Central Eminence_top-relative-expression-ranked_2500_k-means-cluster#3

MLLT3 ZNF609 NRXN3 NRXN1 PCLO KTN1 HNRNPU

7.41e-05893267Facebase_RNAseq_e10.5_Neural Epithelium Overlying Central Eminence_2500_K3
CoexpressionAtlasFacebaseRNAseq_e10.5_Maxillary Arch_top-relative-expression-ranked_2500_k-means-cluster#5

C1D MBTD1 REST KIN KTN1 HNRNPU

9.15e-05629266Facebase_RNAseq_e10.5_Maxillary Arch_2500_K5
CoexpressionAtlasFacebaseRNAseq_e8.5_Hind Brain Neural Epithelium_top-relative-expression-ranked_1000_k-means-cluster#5

MLLT3 PCLO KTN1 HNRNPU

1.05e-04204264Facebase_RNAseq_e8.5_Hind Brain Neural Epithelium_1000_K5
CoexpressionAtlasFacebaseRNAseq_e9.5_Olfactory Placode_top-relative-expression-ranked_1000_k-means-cluster#2

NRXN3 NRXN1 PCLO KTN1

1.17e-04210264Facebase_RNAseq_e9.5_Olfactory Placode_1000_K2
CoexpressionAtlasfacebase_RNAseq_e10.5_NeuroEpith_central_2500_K4

MLLT3 ZNF609 KIN NRXN1 MTDH BRD4 KTN1 HNRNPU

1.61e-041370268facebase_RNAseq_e10.5_NeuroEpith_central_2500_K4
CoexpressionAtlasfacebase_RNAseq_e10.5_Emin_LatNas_2500

C1D NRXN3 KIN MTDH FKBP3 BRD4 KTN1 HNRNPU

2.49e-041459268facebase_RNAseq_e10.5_Emin_LatNas_2500
CoexpressionAtlasFacebaseRNAseq_e8.5_Hind Brain Neural Epithelium_top-relative-expression-ranked_500_k-means-cluster#4

MLLT3 KTN1 HNRNPU

4.58e-04124263Facebase_RNAseq_e8.5_Hind Brain Neural Epithelium_500_K4
CoexpressionAtlasDevelopingGonad_e12.5_ovary_emap-28876_k-means-cluster#1_top-relative-expression-ranked_1000

PWWP2A MBTD1 MACO1

5.26e-04130263gudmap_developingGonad_e12.5_ovary_k1_1000
CoexpressionAtlasFacebaseRNAseq_e9.5_Mandibular Arch_top-relative-expression-ranked_2500_k-means-cluster#2

C1D MBTD1 REST KIN MTDH

5.38e-04564265Facebase_RNAseq_e9.5_Mandibular Arch_2500_K2
CoexpressionAtlasfacebase_RNAseq_e10.5_Emin_LatNas_2500_K3

C1D KIN MTDH FKBP3 BRD4 KTN1 HNRNPU

6.09e-041257267facebase_RNAseq_e10.5_Emin_LatNas_2500_K3
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Neuronal-interneuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PWWP2A ZNF609 NRXN3 CNGA1

3.62e-0617527465571d775d26a40e979dbf290a8e4320c0d9fb3f
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PWWP2A ZNF609 NRXN3 PCLO

4.05e-06180274f6a2208960d0df1500c974cc44c3c054cd7475a9
ToppCellBrain_organoid-organoid_Paulsen_bioRxiv-6_mon-Neuronal|6_mon / Sample Type, Dataset, Time_group, and Cell type.

MLLT3 NRXN3 NRXN1 PCLO

5.90e-06198274076c862f2a723f0361749377561cae902068b1a0
ToppCell(05)_Secretory-(2)_GFP_FOXI1|(05)_Secretory / shred by cell type by condition

REST MTDH BRD4 KTN1

6.02e-06199274d72d87e1e530ed894c0ad5e7b5b2b1d6b59fa098
ToppCell(03)_KRT6B+-(2)_GFP_FOXI1|(03)_KRT6B+ / shred by cell type by condition

REST BRD4 PCLO KTN1

6.02e-06199274c425e7975f492ed5cfcca022248adb627e1d27d4
ToppCell(01)_IL1RL1+-(2)_GFP_FOXI1|(01)_IL1RL1+ / shred by cell type by condition

REST FKBP3 BRD4 KTN1

6.02e-06199274a2f7d0cabf35b80fe239fae34a77bf9344d5d743
ToppCellTCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-7|TCGA-Prostate / Sample_Type by Project: Shred V9

BCCIP FKBP3 MACO1

1.77e-04182273af16334fec2c757b03c84cf252d00e92fa81e4cd
ToppCellfacs-Brain_Non-Myeloid-Cerebellum_-18m-Neuronal-interneuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NRXN3 NRXN1 PCLO

1.92e-041872731b2fdbfb1ce3f19795dfc4b1da5a94f4b057ec41
ToppCellwk_08-11-Hematologic-Meg-ery-Definitive_erythroblast|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

EP300 KIAA0232 MACO1

2.11e-04193273be75abfdf5301cf33df8ee9ed92504d44fdf19a6
ToppCellE16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-PMP-PMP_prolif|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MLLT3 CENPS PA2G4

2.14e-04194273af4bbb2deb5a3913eb58990690fc3c62fbc3708c
ToppCellNeuron-Postmitotic-Inhibitory_Neuron-MGE2|World / Primary Cells by Cluster

NRXN3 NRXN1 PCLO

2.14e-04194273b42fd64b0fb95434a9e4e6586f31d26114a4074b
ToppCellNeuron-Postmitotic-Inhibitory_Neuron-MGE2-10|World / Primary Cells by Cluster

NRXN3 NRXN1 PCLO

2.14e-0419427381e7bc6516ab8d02ccd1c76a56a3533b788c27c8
ToppCellMid-temporal_gyrus_(MTG)-Neuronal|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NRXN3 NRXN1 PCLO

2.20e-04196273676c56b44ac29f7baecb62f49bb8597cc74c0a88
ToppCellBrain_organoid-organoid_Paulsen_bioRxiv-6_mon-Neuronal-PNs|6_mon / Sample Type, Dataset, Time_group, and Cell type.

MLLT3 NRXN1 PCLO

2.24e-0419727310e72b425a2bcba35e63a5b074d3dedcd49a762e
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-2M-Neuronal-ventral_progenitors_and_neurons_1|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.

NRXN3 NRXN1 PCLO

2.24e-041972734961f66606f08e399508fd6cabca588e7ab406a8
ToppCellprimary_auditory_cortex_(A1C)-Neuronal|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NRXN3 NRXN1 PCLO

2.27e-041982736d18b45eda4014759e6dd282d78ffd28df8a6044
ToppCellFetal_29-31_weeks-Epithelial-club_cell-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

MLLT3 NRXN3 PCLO

2.27e-041982736ba5e5970109a04ed968bac7ff099ae250c579dc
ToppCellSomatosensory_Cortex_(S1)-Neuronal|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NRXN3 NRXN1 PCLO

2.27e-04198273c01091ef18e096d792ea2a7a715764a5b215355f
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Newborn-35|World / Primary Cells by Cluster

MLLT3 NRXN3 NRXN1

2.27e-04198273de5214a85fe017eb23d4aa8af624464f062ec57e
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NRXN3 NRXN1 PCLO

2.27e-041982734ca5ff320905ab4ff60ed90a5522227c782142a6
ToppCellNeuron-Postmitotic|World / Primary Cells by Cluster

MLLT3 NRXN1 PCLO

2.31e-041992731973527f8a7d4c6490d75c0d0ea153688166a08b
ToppCell(02)_MMP9/10+-(2)_GFP_FOXI1|(02)_MMP9/10+ / shred by cell type by condition

REST BRD4 KTN1

2.31e-0419927318a7f9ced4364f45b184bd529f32ef02c27779d3
ToppCell(10)_Ciliated-(2)_GFP_FOXI1|(10)_Ciliated / shred by cell type by condition

REST BRD4 KTN1

2.31e-0419927361b1ed2db71b96157b92b7535d1955a4033098da
ToppCell(04)_Interm._basal>secr.-(2)_GFP_FOXI1|(04)_Interm._basal>secr. / shred by cell type by condition

REST BRD4 KTN1

2.31e-0419927353ca3861f9e00dab3f3fbefb0837857ee39ab084
ToppCell(09)_Interm._secr.>cil.-(2)_GFP_FOXI1|(09)_Interm._secr.>cil. / shred by cell type by condition

REST BRD4 KTN1

2.31e-04199273fc680f85ebd3bab4c72876a19a461b0afb5f51ce
ToppCellmegakaryocytic-CD34+_Megakaryoblast|megakaryocytic / Lineage and Cell class

PA2G4 MTDH KTN1

2.31e-0419927399a65887d3c8a2cde26693dd74404b101bba9d58
ToppCellNeuron|World / Primary Cells by Cluster

MLLT3 NRXN1 PCLO

2.31e-041992731f8104fd92f04690b41d9d07ac08dc59d76bb97d
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-4M-Neuronal|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.

NRXN1 MACO1 PCLO

2.31e-0419927377b4aa00f14b86ef5db0490be98787e063979541
ToppCellHSPCs|World / Lineage and Cell class

PA2G4 FKBP3 HNRNPU

2.31e-04199273df1ffc416c6946f1ba182f242a50ee41a571d565
ToppCell(00)_Basal-(2)_GFP_FOXI1|(00)_Basal / shred by cell type by condition

REST BRD4 KTN1

2.31e-0419927319674e1eaeb51e4196d847cb62aa437c852951d3
ToppCellNeuron-Postmitotic-Excitatory_Neuron_|World / Primary Cells by Cluster

MLLT3 NRXN1 PCLO

2.31e-04199273058373b4ac3cec2108cb24265628ff0a50646e33
ToppCellBrain_organoid-organoid_Tanaka_cellReport-10w|organoid_Tanaka_cellReport / Sample Type, Dataset, Time_group, and Cell type.

NRXN3 NRXN1 PCLO

2.34e-04200273ac0e023dbb383bbc46c5cc525431778be8f7ef46
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW16-Neuronal|GW16 / Sample Type, Dataset, Time_group, and Cell type.

MLLT3 NRXN1 PCLO

2.34e-0420027384e4565d28a02700bf7f6730d1b3a58744ca0aea
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Upper_Layer|World / Primary Cells by Cluster

ARHGAP20 NRXN1 PCLO

2.34e-04200273db10f76938af553d1a2275bb02ef75dff3c3135b
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW16-Neuronal|GW16 / Sample Type, Dataset, Time_group, and Cell type.

MLLT3 NRXN1 PCLO

2.34e-042002731decf1d2cba5ebfd3e5cd4bcd637db8f193033ce
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW16-Neuronal-Cortical_neuron|GW16 / Sample Type, Dataset, Time_group, and Cell type.

MLLT3 NRXN1 PCLO

2.34e-0420027319055194a5e0ea122f1b8fc62df44813f6843c95
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Upper_Layer-21|World / Primary Cells by Cluster

ARHGAP20 NRXN1 PCLO

2.34e-0420027330a3e4aee12ec1b5acdce90f86c9733c27a7f6fc
ToppCellBrain_organoid-organoid_Tanaka_cellReport-3m-Neuronal-Cortical_neuron|3m / Sample Type, Dataset, Time_group, and Cell type.

MLLT3 NRXN1 PCLO

2.34e-04200273c248233b004f8ef0bab3c65ecfe295887966f2ee
ToppCellBrain_organoid-organoid_Tanaka_cellReport-3m-Neuronal|3m / Sample Type, Dataset, Time_group, and Cell type.

MLLT3 NRXN1 PCLO

2.34e-04200273af99d90070e2933fd2e9512590c6cf3bd6e15539
ToppCellBrain_organoid-organoid_Tanaka_cellReport-10w-Neuronal-Interneuron|10w / Sample Type, Dataset, Time_group, and Cell type.

NRXN3 NRXN1 PCLO

2.34e-04200273f5c63ef52bd7a898cf009b8bf9b2f7f4890d1c9b
DrugFluocinonide [356-12-7]; Down 200; 8uM; PC3; HT_HG-U133A

CYLC1 MLLT3 NRXN3 MACO1 HNRNPU

3.27e-061982753757_DN
Drug6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide

REST EP300 BRD4

3.16e-0552273ctd:C550547
DrugKawain [500-64-1]; Down 200; 17.4uM; MCF7; HT_HG-U133A

MBTD1 ZNF609 REST HNRNPU

7.10e-051902742299_DN
DrugApomorphine hydrochloride hemihydrate [41372-20-7]; Down 200; 6.4uM; MCF7; HT_HG-U133A

MBTD1 ZNF609 BRD4 HNRNPU

7.85e-051952741505_DN
DrugHesperetin [520-33-2]; Down 200; 13.2uM; MCF7; HT_HG-U133A

CYLC1 MBTD1 ZNF609 BRD4

8.00e-051962741531_DN
DrugDobutamine hydrochloride [49745-95-1]; Down 200; 11.8uM; MCF7; HT_HG-U133A

CYLC1 MBTD1 ZNF609 HNRNPU

8.00e-051962745386_DN
DrugIsoniazid [54-85-3]; Up 200; 29.2uM; HL60; HG-U133A

ZNF609 FEZ2 EP300 KTN1

8.00e-051962741399_UP
DrugMecamylamine hydrochloride [826-39-1]; Up 200; 19.6uM; PC3; HT_HG-U133A

CYLC1 MBTD1 NRXN3 BRD4

8.00e-051962747263_UP
DrugMetrizamide [31112-62-6]; Down 200; 5uM; MCF7; HT_HG-U133A

CYLC1 MBTD1 ZNF609 REST

8.00e-051962743255_DN
DrugThioproperazine dimesylate [2347-80-0]; Up 200; 6.2uM; PC3; HT_HG-U133A

CYLC1 MBTD1 ZNF609 BRD4

8.00e-051962742073_UP
DrugMidecamycin [35457-80-8]; Down 200; 5uM; MCF7; HT_HG-U133A

MBTD1 ZNF609 BRD4 HNRNPU

8.16e-051972741526_DN
DrugMianserine hydrochloride [21535-47-7]; Up 200; 13.2uM; HL60; HG-U133A

MBTD1 ZNF609 FEZ2 MACO1

8.16e-051972741385_UP
DrugPentolinium bitartrate [52-62-0]; Down 200; 7.4uM; MCF7; HT_HG-U133A

CYLC1 ZNF609 REST MACO1

8.16e-051972744699_DN
DrugSulfacetamide sodic hydrate [6209-17-2]; Up 200; 15.8uM; HL60; HT_HG-U133A

MLLT3 ZNF609 REST FEZ2

8.32e-051982741859_UP
DrugRisperidone [106266-06-2]; Up 200; 9.8uM; HL60; HT_HG-U133A

MLLT3 ZNF609 BRD4 HNRNPU

8.32e-051982742947_UP
DrugDihydroergocristine mesylate [24730-10-7]; Up 200; 5.6uM; PC3; HT_HG-U133A

CYLC1 MBTD1 ZNF609 NRXN3

8.49e-051992747275_UP
DrugClonidine hydrochloride [4205-91-8]; Down 200; 15uM; MCF7; HT_HG-U133A

MLLT3 ZNF609 REST HNRNPU

8.49e-051992746814_DN
DrugAC1NB8R3

NRXN3 REST NRXN1 HNRNPU

1.10e-04213274CID004489307
DiseaseSchizoaffective disorder-bipolar type

NRXN3 PCLO

9.60e-0516272EFO_0009965
Diseaseplatelet measurement

PWWP2A RALB REST KIAA0232

1.84e-04315274EFO_0005036
Diseasecaudate volume change measurement, age at assessment

NRXN3 NRXN1

2.79e-0427272EFO_0008007, EFO_0021491
Diseasemean reticulocyte volume

MLLT3 REST KIN MACO1 BRD4

7.07e-04799275EFO_0010701
Diseasepain

C1D REST NRXN1

7.51e-04196273EFO_0003843
Diseaseintraocular pressure measurement

RALB ARHGAP20 FEZ2 PCLO

1.12e-03509274EFO_0004695
Diseaseobsolete_red blood cell distribution width

BCCIP REST MTDH EP300 KIAA0232 BRD4

1.16e-031347276EFO_0005192
Diseaseword reading

MLLT3 NRXN3

1.62e-0365272EFO_0005300
DiseaseAlcoholic Intoxication, Chronic

C1D NRXN3 EP300

1.84e-03268273C0001973
DiseaseAutism Spectrum Disorders

NRXN3 NRXN1

2.75e-0385272C1510586
Diseasemigraine disorder, Headache

C1D REST

2.81e-0386272HP_0002315, MONDO_0005277
Diseasecoronary artery disease

C1D MBTD1 REST ARHGAP20 NRXN1

4.13e-031194275EFO_0001645
Diseaseplatelet component distribution width

PWWP2A RALB MLLT3 KIAA0232

4.67e-03755274EFO_0007984
Diseaserisk-taking behaviour

NRXN3 REST NRXN1 EP300

4.87e-03764274EFO_0008579
Diseasealcohol consumption measurement

NRXN3 REST NRXN1 EP300 PCLO

4.88e-031242275EFO_0007878
Diseaseirritable bowel syndrome

EP300 PCLO

6.38e-03131272EFO_0000555

Protein segments in the cluster

PeptideGeneStartEntry
TKGDSKNAKKKNNKK

EP300

1541

Q09472
KAQKKKKSEDGSKNS

CENPS

111

Q8N2Z9
KKTKKNNSSNSNVSK

BRD4

571

O60885
NKSSKESSKKPKENK

MLLT3

226

P42568
DKNGKKSSKNKKSFK

RALB

186

P11234
QSSTQSKEKKKKKSA

KIN

246

O60870
TQKKKKKKASKTAEN

PA2G4

366

Q9UQ80
TKKKKKVESKSKNNS

REST

541

Q13127
AKSSNKNKKNKDKEY

NRXN1

456

P58400
ASSKQKKKAKSQQYK

MBTD1

571

Q05BQ5
KNNSKKKPSNKKKAA

BCCIP

231

Q9P287
KSKNASKVANKGKSK

C1D

126

Q13901
SSSKNEKKQKCTSKS

MACO1

346

Q8N5G2
EQQQRKSSSKKSKKD

PCLO

1796

Q9Y6V0
KTQSKSKNEKENKFS

KIAA0232

246

Q92628
VSKNCSQKDKKDSKN

CYLC1

191

P35663
SQKDKKDSKNSKKTN

CYLC1

196

P35663
KKDSKTDNKKSVKND

CYLC1

426

P35663
KKQNTGSKKSNKNKS

HNRNPU

681

Q00839
KEKQQSSKSGHKKQK

NRXN3

1621

Q9Y4C0
SQKKSSQKKSSKKNH

ISG20L2

136

Q9H9L3
SGKKKASSKKQKTEN

KTN1

206

Q86UP2
AKSSNKNKKNKDKEY

NRXN1

1461

Q9ULB1
DTNIQTSAKKKKNAK

FKBP3

146

Q00688
KKKSKSDAKAVQNSS

MTDH

166

Q86UE4
TAKKKKKLKNGSSQN

FEZ2

276

Q9UHY8
DVSKKNATTQNTKKK

ARHGAP20

766

Q9P2F6
KEKAQKKQNETSTSK

PWWP2A

436

Q96N64
KEKKSKSDDKNENKN

CNGA1

106

P29973
SKKEKENSSSKSKKE

ZNF609

156

O15014