Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	G protein-coupled receptor activity	MC5R OR4D1 ADORA1 GPR84 OR4C13 OR5J2 OR4X2 TAAR8 LPAR4 LGR5 OR4D9	2.41e-06	884	44	11	GO:0004930
GeneOntologyMolecularFunction	serine-type endopeptidase activity	TMPRSS9 PRTN3 TYSND1 OVCH1 PRSS12 CFB	3.58e-06	190	44	6	GO:0004252
GeneOntologyMolecularFunction	serine-type peptidase activity	TMPRSS9 PRTN3 TYSND1 OVCH1 PRSS12 CFB	5.87e-06	207	44	6	GO:0008236
GeneOntologyMolecularFunction	transmembrane transporter activity	SLC19A2 STIM1 SLC7A5 SLC24A4 CLCN6 SLC17A1 ATP2B3 SLC25A2 SLC9A6 SLC7A5P2 SLC38A8 TTYH2	6.19e-06	1180	44	12	GO:0022857
GeneOntologyMolecularFunction	serine hydrolase activity	TMPRSS9 PRTN3 TYSND1 OVCH1 PRSS12 CFB	6.73e-06	212	44	6	GO:0017171
GeneOntologyMolecularFunction	antiporter activity	SLC7A5 SLC24A4 CLCN6 SLC25A2 SLC9A6	1.28e-05	138	44	5	GO:0015297
GeneOntologyMolecularFunction	transporter activity	SLC19A2 STIM1 SLC7A5 SLC24A4 CLCN6 SLC17A1 ATP2B3 SLC25A2 SLC9A6 SLC7A5P2 SLC38A8 TTYH2	1.52e-05	1289	44	12	GO:0005215
GeneOntologyMolecularFunction	secondary active transmembrane transporter activity	SLC7A5 SLC24A4 CLCN6 SLC17A1 SLC25A2 SLC9A6	4.43e-05	296	44	6	GO:0015291
GeneOntologyMolecularFunction	active transmembrane transporter activity	SLC7A5 SLC24A4 CLCN6 SLC17A1 ATP2B3 SLC25A2 SLC9A6	7.57e-05	477	44	7	GO:0022804
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	MC5R OR4D1 ADORA1 GPR84 OR4C13 OR5J2 OR4X2 TAAR8 LPAR4 LGR5 OR4D9	1.27e-04	1353	44	11	GO:0004888
GeneOntologyMolecularFunction	endopeptidase activity	TMPRSS9 PRTN3 TYSND1 OVCH1 PRSS12 CFB	3.40e-04	430	44	6	GO:0004175
GeneOntologyMolecularFunction	L-amino acid transmembrane transporter activity	SLC7A5 SLC25A2 SLC38A8	5.14e-04	71	44	3	GO:0015179
GeneOntologyMolecularFunction	peptidase activity	TINAGL1 TMPRSS9 PRTN3 TYSND1 OVCH1 PRSS12 CFB	5.22e-04	654	44	7	GO:0008233
GeneOntologyMolecularFunction	solute:potassium antiporter activity	SLC24A4 SLC9A6	7.92e-04	19	44	2	GO:0022821
GeneOntologyMolecularFunction	organic cation transmembrane transporter activity	SLC19A2 SLC7A5 SLC25A2	8.11e-04	83	44	3	GO:0015101
GeneOntologyMolecularFunction	carboxylic acid transmembrane transporter activity	SLC19A2 SLC7A5 SLC25A2 SLC38A8	1.10e-03	207	44	4	GO:0046943
GeneOntologyMolecularFunction	organic acid transmembrane transporter activity	SLC19A2 SLC7A5 SLC25A2 SLC38A8	1.12e-03	208	44	4	GO:0005342
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	STIM1 SLC24A4 CLCN6 SLC17A1 ATP2B3 SLC9A6 TTYH2	1.24e-03	758	44	7	GO:0015318
GeneOntologyMolecularFunction	amino acid transmembrane transporter activity	SLC7A5 SLC25A2 SLC38A8	1.60e-03	105	44	3	GO:0015171
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	STIM1 SLC24A4 CLCN6 SLC17A1 ATP2B3 SLC9A6 TTYH2	1.61e-03	793	44	7	GO:0015075
GeneOntologyMolecularFunction	olfactory receptor activity	OR4D1 OR4C13 OR5J2 OR4X2 OR4D9	2.49e-03	431	44	5	GO:0004984
GeneOntologyMolecularFunction	G protein-coupled peptide receptor activity	MC5R GPR84 LGR5	3.13e-03	133	44	3	GO:0008528
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	STIM1 SLC24A4 SLC17A1 ATP2B3 SLC9A6	3.45e-03	465	44	5	GO:0046873
GeneOntologyMolecularFunction	peptide receptor activity	MC5R GPR84 LGR5	3.62e-03	140	44	3	GO:0001653
GeneOntologyMolecularFunction	organic anion transmembrane transporter activity	SLC19A2 SLC7A5 SLC25A2 SLC38A8	3.89e-03	293	44	4	GO:0008514
GeneOntologyMolecularFunction	metal cation:monoatomic cation antiporter activity	SLC24A4 SLC9A6	4.05e-03	43	44	2	GO:0140828
GeneOntologyMolecularFunction	active monoatomic ion transmembrane transporter activity	SLC24A4 SLC17A1 ATP2B3 SLC9A6	4.28e-03	301	44	4	GO:0022853
GeneOntologyMolecularFunction	calcium ion transmembrane transporter activity	STIM1 SLC24A4 ATP2B3	4.47e-03	151	44	3	GO:0015085
GeneOntologyMolecularFunction	inorganic anion transmembrane transporter activity	CLCN6 SLC17A1 TTYH2	6.32e-03	171	44	3	GO:0015103
GeneOntologyMolecularFunction	sodium ion transmembrane transporter activity	SLC24A4 SLC17A1 SLC9A6	6.32e-03	171	44	3	GO:0015081
GeneOntologyBiologicalProcess	G protein-coupled receptor signaling pathway	MC5R OR4D1 STIM1 ADORA1 GPR84 OR4C13 OR5J2 OR4X2 C5 TAAR8 LPAR4 SLC24A4 LGR5 OR4D9	6.58e-07	1395	44	14	GO:0007186
GeneOntologyBiologicalProcess	L-alpha-amino acid transmembrane transport	SLC7A5 SLC25A2 SLC7A5P2 SLC38A8 TTYH2	1.13e-06	87	44	5	GO:1902475
GeneOntologyBiologicalProcess	L-amino acid transport	SLC7A5 SLC25A2 SLC7A5P2 SLC38A8 TTYH2	3.31e-06	108	44	5	GO:0015807
GeneOntologyBiologicalProcess	amino acid transport	ADORA1 SLC7A5 SLC25A2 SLC7A5P2 SLC38A8 TTYH2	3.46e-06	195	44	6	GO:0006865
GeneOntologyBiologicalProcess	amino acid transmembrane transport	SLC7A5 SLC25A2 SLC7A5P2 SLC38A8 TTYH2	5.55e-06	120	44	5	GO:0003333
GeneOntologyBiologicalProcess	organic anion transport	SLC19A2 ADORA1 SLC7A5 SLC17A1 SLC25A2 SLC7A5P2 SLC38A8 TTYH2	1.15e-05	515	44	8	GO:0015711
GeneOntologyBiologicalProcess	carboxylic acid transport	SLC19A2 ADORA1 SLC7A5 SLC25A2 SLC7A5P2 SLC38A8 TTYH2	2.37e-05	410	44	7	GO:0046942
GeneOntologyBiologicalProcess	organic acid transport	SLC19A2 ADORA1 SLC7A5 SLC25A2 SLC7A5P2 SLC38A8 TTYH2	2.44e-05	412	44	7	GO:0015849
GeneOntologyBiologicalProcess	carboxylic acid transmembrane transport	SLC7A5 SLC25A2 SLC7A5P2 SLC38A8 TTYH2	2.45e-05	163	44	5	GO:1905039
GeneOntologyBiologicalProcess	organic acid transmembrane transport	SLC7A5 SLC25A2 SLC7A5P2 SLC38A8 TTYH2	2.76e-05	167	44	5	GO:1903825
GeneOntologyBiologicalProcess	sensory perception	OR4D1 ADORA1 OR4C13 OR5J2 OR4X2 SLC24A4 OR4D9 SLC38A8 CLRN2 GET1	6.79e-05	1072	44	10	GO:0007600
GeneOntologyBiologicalProcess	detection of chemical stimulus	OR4D1 STIM1 OR4C13 OR5J2 OR4X2 SLC24A4 OR4D9	1.11e-04	524	44	7	GO:0009593
GeneOntologyBiologicalProcess	detection of stimulus	OR4D1 STIM1 ADORA1 OR4C13 OR5J2 OR4X2 SLC24A4 OR4D9	1.26e-04	722	44	8	GO:0051606
GeneOntologyBiologicalProcess	detection of stimulus involved in sensory perception	OR4D1 ADORA1 OR4C13 OR5J2 OR4X2 SLC24A4 OR4D9	2.13e-04	582	44	7	GO:0050906
GeneOntologyBiologicalProcess	calcium ion export across plasma membrane	SLC24A4 ATP2B3	2.90e-04	12	44	2	GO:1990034
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception of smell	OR4D1 OR4C13 OR5J2 OR4X2 SLC24A4 OR4D9	2.93e-04	432	44	6	GO:0050911
GeneOntologyBiologicalProcess	sensory perception of smell	OR4D1 OR4C13 OR5J2 OR4X2 SLC24A4 OR4D9	4.34e-04	465	44	6	GO:0007608
GeneOntologyBiologicalProcess	monoatomic ion transport	STIM1 ADORA1 SLC24A4 CLCN6 SLC17A1 ATP2B3 SLC9A6 CLDN10 CASK TTYH2	5.12e-04	1374	44	10	GO:0006811
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception	OR4D1 OR4C13 OR5J2 OR4X2 SLC24A4 OR4D9	5.42e-04	485	44	6	GO:0050907
GeneOntologyBiologicalProcess	complement activation, alternative pathway	C5 CFB	7.43e-04	19	44	2	GO:0006957
GeneOntologyBiologicalProcess	basic amino acid transport	SLC7A5 SLC25A2	1.00e-03	22	44	2	GO:0015802
GeneOntologyBiologicalProcess	sensory perception of chemical stimulus	OR4D1 OR4C13 OR5J2 OR4X2 SLC24A4 OR4D9	1.01e-03	547	44	6	GO:0007606
Domain	GPCR_Rhodpsn_7TM	MC5R OR4D1 ADORA1 GPR84 OR4C13 OR5J2 OR4X2 TAAR8 LPAR4 LGR5 OR4D9	2.35e-07	670	43	11	IPR017452
Domain	7tm_1	MC5R OR4D1 ADORA1 GPR84 OR4C13 OR5J2 OR4X2 TAAR8 LPAR4 LGR5 OR4D9	2.61e-07	677	43	11	PF00001
Domain	Tryp_SPc	TMPRSS9 PRTN3 TYSND1 OVCH1 PRSS12 CFB	2.68e-07	117	43	6	SM00020
Domain	G_PROTEIN_RECEP_F1_1	MC5R OR4D1 ADORA1 GPR84 OR4C13 OR5J2 OR4X2 TAAR8 LPAR4 LGR5 OR4D9	2.94e-07	685	43	11	PS00237
Domain	G_PROTEIN_RECEP_F1_2	MC5R OR4D1 ADORA1 GPR84 OR4C13 OR5J2 OR4X2 TAAR8 LPAR4 LGR5 OR4D9	3.20e-07	691	43	11	PS50262
Domain	GPCR_Rhodpsn	MC5R OR4D1 ADORA1 GPR84 OR4C13 OR5J2 OR4X2 TAAR8 LPAR4 LGR5 OR4D9	3.25e-07	692	43	11	IPR000276
Domain	Trypsin	TMPRSS9 PRTN3 TYSND1 OVCH1 PRSS12 CFB	3.27e-07	121	43	6	PF00089
Domain	Trypsin_dom	TMPRSS9 PRTN3 TYSND1 OVCH1 PRSS12 CFB	3.27e-07	121	43	6	IPR001254
Domain	Peptidase_S1_PA	TMPRSS9 PRTN3 TYSND1 OVCH1 PRSS12 CFB	3.60e-07	123	43	6	IPR009003
Domain	TRYPSIN_SER	TMPRSS9 PRTN3 OVCH1 PRSS12 CFB	1.93e-06	90	43	5	IPR033116
Domain	TRYPSIN_HIS	TMPRSS9 PRTN3 OVCH1 PRSS12 CFB	3.77e-06	103	43	5	IPR018114
Domain	TRYPSIN_SER	TMPRSS9 PRTN3 OVCH1 PRSS12 CFB	4.34e-06	106	43	5	PS00135
Domain	TRYPSIN_HIS	TMPRSS9 PRTN3 OVCH1 PRSS12 CFB	4.55e-06	107	43	5	PS00134
Domain	Peptidase_S1A	TMPRSS9 PRTN3 OVCH1 PRSS12 CFB	5.94e-06	113	43	5	IPR001314
Domain	TRYPSIN_DOM	TMPRSS9 PRTN3 OVCH1 PRSS12 CFB	6.48e-06	115	43	5	PS50240
Domain	PMP22_Claudin	CLDN11 CLDN10 CLRN2	1.06e-04	40	43	3	PF00822
Domain	7TM_GPCR_Srsx	MC5R ADORA1 TAAR8 LPAR4	1.26e-04	112	43	4	SM01381
Domain	PMP22/EMP/MP20/Claudin	CLDN11 CLDN10 CLRN2	1.51e-04	45	43	3	IPR004031
Domain	Claudin_CS	CLDN11 CLDN10	1.16e-03	22	43	2	IPR017974
Domain	CLAUDIN	CLDN11 CLDN10	1.16e-03	22	43	2	PS01346
Domain	Claudin	CLDN11 CLDN10	1.88e-03	28	43	2	IPR006187
Domain	Olfact_rcpt	OR4D1 OR4C13 OR5J2 OR4X2 OR4D9	2.01e-03	393	43	5	IPR000725
Pathway	REACTOME_ACTIVATION_OF_C3_AND_C5	C5 CFB	1.40e-04	7	37	2	MM14685
Pathway	REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES	SLC7A5 SLC24A4 SLC17A1 SLC9A6	1.77e-04	108	37	4	M823
Pathway	REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES	SLC7A5 SLC24A4 SLC17A1 SLC9A6	1.84e-04	109	37	4	MM15074
Pathway	REACTOME_ACTIVATION_OF_C3_AND_C5	C5 CFB	1.86e-04	8	37	2	M27031
Pathway	BIOCARTA_ALTERNATIVE_PATHWAY	C5 CFB	2.39e-04	9	37	2	M22072
Pathway	WP_ACQUIRED_PARTIAL_LIPODYSTROPHY_BARRAQUERSIMONS_SYNDROME	C5 CFB	2.98e-04	10	37	2	M42576
Pathway	WP_NUCLEOTIDE_GPCRS	ADORA1 LPAR4	3.63e-04	11	37	2	M39422
Pathway	WP_NUCLEOTIDE_GPCRS	ADORA1 LPAR4	4.35e-04	12	37	2	MM15953
Pathway	REACTOME_NUCLEOTIDE_LIKE_PURINERGIC_RECEPTORS	ADORA1 LPAR4	7.86e-04	16	37	2	M6786
Pathway	REACTOME_NUCLEOTIDE_LIKE_PURINERGIC_RECEPTORS	ADORA1 LPAR4	7.86e-04	16	37	2	MM15050
Pathway	BIOCARTA_COMP_PATHWAY	C5 CFB	1.24e-03	20	37	2	M917
Pathway	WP_COMPLEMENT_ACTIVATION	C5 CFB	1.50e-03	22	37	2	M39502
Pathway	REACTOME_CLASS_A_1_RHODOPSIN_LIKE_RECEPTORS	MC5R ADORA1 C5 TAAR8 LPAR4	1.61e-03	330	37	5	M18334
Pathway	REACTOME_CLASS_A_1_RHODOPSIN_LIKE_RECEPTORS	MC5R ADORA1 C5 TAAR8 LPAR4	1.67e-03	333	37	5	MM14963
Pathway	REACTOME_TRANSPORT_OF_SMALL_MOLECULES	SLC7A5 SLC24A4 CLCN6 SLC17A1 ATP2B3 SLC9A6 TTYH2	1.72e-03	681	37	7	MM14985
Pathway	REACTOME_PLATELET_CALCIUM_HOMEOSTASIS	STIM1 ATP2B3	2.43e-03	28	37	2	M924
Pathway	REACTOME_TRANSPORT_OF_SMALL_MOLECULES	SLC7A5 SLC24A4 CLCN6 SLC17A1 ATP2B3 SLC9A6 TTYH2	2.68e-03	736	37	7	M27287
Pathway	REACTOME_TIGHT_JUNCTION_INTERACTIONS	CLDN11 CLDN10	2.78e-03	30	37	2	M17967
Pathway	KEGG_OLFACTORY_TRANSDUCTION	OR4D1 OR4C13 OR5J2 OR4X2 OR4D9	3.29e-03	389	37	5	M14091
Pathway	WP_PURINERGIC_SIGNALING	ADORA1 LPAR4	3.36e-03	33	37	2	M39855
Pathway	REACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT	SLC7A5 SLC24A4 SLC17A1 SLC9A6	3.38e-03	238	37	4	MM15076
Pathway	REACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT	SLC7A5 SLC24A4 SLC17A1 SLC9A6	3.97e-03	249	37	4	M5988
Pubmed	STIM1 and SLC24A4 Are Critical for Enamel Maturation.	STIM1 SLC24A4	1.56e-06	2	44	2	24621671
Pubmed	Alterations in gene expression of complement components in chronic rhinosinusitis.	C5 CFB	4.69e-06	3	44	2	20109314
Pubmed	Reverse mode Na+/Ca2+ exchange mediated by STIM1 contributes to Ca2+ influx in airway smooth muscle following agonist stimulation.	STIM1 SLC24A4	4.69e-06	3	44	2	21126331
Pubmed	Expression of the complement system's activation factors in plasma of patients with early/late-onset severe pre-eclampsia.	C5 CFB	4.69e-06	3	44	2	27461873
Pubmed	Complement C3b interactions studied with surface plasmon resonance technique.	C5 CFB	9.37e-06	4	44	2	11367533
Pubmed	Properdin provides protection from Citrobacter rodentium-induced intestinal inflammation in a C5a/IL-6-dependent manner.	C5 CFB	9.37e-06	4	44	2	25725105
Pubmed	Mobilization studies in complement-deficient mice reveal that optimal AMD3100 mobilization of hematopoietic stem cells depends on complement cascade activation by AMD3100-stimulated granulocytes.	C5 CFB	9.37e-06	4	44	2	20033053
Pubmed	Alternative complement pathway in the pathogenesis of disease mediated by anti-neutrophil cytoplasmic autoantibodies.	C5 CFB	1.56e-05	5	44	2	17200182
Pubmed	Claudin-11/OSP-based tight junctions of myelin sheaths in brain and Sertoli cells in testis.	CLDN11 CLDN10	1.56e-05	5	44	2	10225958
Pubmed	Complement activation via alternative pathway is critical in the development of laser-induced choroidal neovascularization: role of factor B and factor H.	C5 CFB	2.34e-05	6	44	2	16849499
Pubmed	The Complement System Is Critical in Maintaining Retinal Integrity during Aging.	C5 CFB	2.34e-05	6	44	2	29497373
Pubmed	The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer.	SLC7A5 LGR5	2.34e-05	6	44	2	33414552
Pubmed	Complement activation pathways in murine immune complex-induced arthritis and in C3a and C5a generation in vitro.	C5 CFB	2.34e-05	6	44	2	19843088
Pubmed	Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndrome.	C5 CFB	3.27e-05	7	44	2	14660741
Pubmed	Efficient osteoclast differentiation requires local complement activation.	C5 CFB	3.27e-05	7	44	2	20709903
Pubmed	CD4+ T cells reactive to a hybrid peptide from insulin-chromogranin A adopt a distinct effector fate and are pathogenic in autoimmune diabetes.	GPR84 C5	3.27e-05	7	44	2	39214091
Pubmed	Uncoupling of Natural Killer cell functional maturation and cytolytic function in NOD mice.	GPR84 C5	3.27e-05	7	44	2	37536708
Pubmed	Up-regulated expression of a novel gene in activated human peripheral blood mononuclear cells that is a truncated paralog of the human system L-amino acid transporter 1.	SLC7A5 SLC7A5P2	3.27e-05	7	44	2	12009310
Pubmed	Synergy between the classical and alternative pathways of complement is essential for conferring effective protection against the pandemic influenza A(H1N1) 2009 virus infection.	C5 CFB	4.36e-05	8	44	2	28301559
Pubmed	Antitumor efficacy of 90Y-NM600 targeted radionuclide therapy and PD-1 blockade is limited by regulatory T cells in murine prostate tumors.	GPR84 C5	4.36e-05	8	44	2	36002185
Pubmed	Molecular organization and function of the complement system.	C5 CFB	4.36e-05	8	44	2	3052276
Pubmed	C3 opsonization regulates endocytic handling of apoptotic cells resulting in enhanced T-cell responses to cargo-derived antigens.	C5 CFB	4.36e-05	8	44	2	24474777
Pubmed	The role of complement in cryoglobulin-induced immune complex glomerulonephritis.	C5 CFB	4.36e-05	8	44	2	16272350
Pubmed	Expression patterns of claudins, tight junction adhesion molecules, in the inner ear.	CLDN11 CLDN10	5.60e-05	9	44	2	14698084
Pubmed	Developmental changes in the expression of tight junction protein claudins in murine metanephroi and embryonic kidneys.	CLDN11 CLDN10	6.99e-05	10	44	2	16520537
Pubmed	Permeability barrier dysfunction in transgenic mice overexpressing claudin 6.	CLDN11 CLDN10	6.99e-05	10	44	2	11923212
Pubmed	Expression of claudins in murine tooth development.	CLDN11 CLDN10	8.54e-05	11	44	2	17075866
Pubmed	Deficiency of decay-accelerating factor and complement receptor 1-related gene/protein y on murine platelets leads to complement-dependent clearance by the macrophage phagocytic receptor CRIg.	C5 CFB	1.02e-04	12	44	2	18524992
Pubmed	Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors.	ADORA1 C5 TAAR8 LPAR4	1.20e-04	200	44	4	18240029
Pubmed	Expression patterns of claudin family of tight junction membrane proteins in developing mouse submandibular gland.	CLDN11 CLDN10	1.41e-04	14	44	2	15366020
Pubmed	Partial transcriptome of the developing pituitary gland.	CLDN11 CASK	1.86e-04	16	44	2	11161784
Pubmed	Probiotic bacteria induce maturation of intestinal claudin 3 expression and barrier function.	CLDN11 CLDN10	2.64e-04	19	44	2	22155109
Pubmed	Biology of claudins.	CLDN11 CLDN10	2.64e-04	19	44	2	18480174
Pubmed	Tight junction proteins.	CLDN11 CLDN10	3.24e-04	21	44	2	12475568
Pubmed	Multifunctional strands in tight junctions.	CLDN11 CLDN10	3.24e-04	21	44	2	11283726
Pubmed	Claudin-based barrier in simple and stratified cellular sheets.	CLDN11 CLDN10	3.24e-04	21	44	2	12231346
Pubmed	Tight junctions of the blood-brain barrier.	CLDN11 CLDN10	3.24e-04	21	44	2	10690502
Pubmed	The roles of claudin superfamily proteins in paracellular transport.	CLDN11 CLDN10	3.24e-04	21	44	2	11247307
Pubmed	Structure and function of claudins.	CLDN11 CLDN10	3.89e-04	23	44	2	18036336
Pubmed	The claudins.	CLDN11 CLDN10	3.89e-04	23	44	2	19706201
Pubmed	Antibodies and complement are key drivers of thrombosis.	C5 CFB	3.89e-04	23	44	2	39226900
Pubmed	Identification of Peroxisomal Protein Complexes with PTS Receptors, Pex5 and Pex7, in Mammalian Cells.	TYSND1 ACAD11	4.99e-04	26	44	2	30378028
Pubmed	Dynamic distribution of claudin proteins in pancreatic epithelia undergoing morphogenesis or neoplastic transformation.	CLDN11 CLDN10	4.99e-04	26	44	2	22275141
Pubmed	SOX9 and SOX10 control fluid homeostasis in the inner ear for hearing through independent and cooperative mechanisms.	CLDN11 SLC24A4	5.38e-04	27	44	2	36343245
Pubmed	Two proteases, trypsin domain-containing 1 (Tysnd1) and peroxisomal lon protease (PsLon), cooperatively regulate fatty acid β-oxidation in peroxisomal matrix.	TYSND1 ACAD11	5.79e-04	28	44	2	22002062
Pubmed	Sox21 Regulates Anapc10 Expression and Determines the Fate of Ectodermal Organ.	SLC24A4 LGR5	5.79e-04	28	44	2	32674056
Pubmed	The human olfactory receptor gene family.	OR4D1 OR4C13 OR5J2 OR4X2 OR4D9	5.89e-04	541	44	5	14983052
Pubmed	Fgf10 is required for specification of non-sensory regions of the cochlear epithelium.	CLDN11 LGR5	6.21e-04	29	44	2	25624266
Pubmed	Risk of non-Hodgkin lymphoma in association with germline variation in complement genes.	C5 CFB	7.11e-04	31	44	2	19344414
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR4D1 OR4C13 OR5J2 OR4X2	8.95e-04	340	44	4	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR4D1 OR4C13 OR5J2 OR4X2	8.95e-04	340	44	4	11802173
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR4D1 OR4C13 OR5J2 OR4X2	9.25e-04	343	44	4	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR4D1 OR4C13 OR5J2 OR4X2	9.55e-04	346	44	4	14611657
Interaction	C5AR1 interactions	SLC19A2 C5 ATP2B3 TTYH2 PTDSS1	1.14e-05	154	39	5	int:C5AR1
GeneFamily	Solute carriers	SLC19A2 SLC7A5 SLC24A4 SLC17A1 SLC25A2 SLC9A6 SLC38A8	5.89e-06	395	33	7	752
GeneFamily	Olfactory receptors, family 4	OR4D1 OR4C13 OR4X2 OR4D9	8.62e-05	129	33	4	151
GeneFamily	Claudins	CLDN11 CLDN10	7.98e-04	23	33	2	488
GeneFamily	Complement system\|Sushi domain containing	C5 CFB	1.96e-03	36	33	2	492
GeneFamily	Proteases, serine	TMPRSS9 PRSS12	5.89e-03	63	33	2	738
GeneFamily	G protein-coupled receptors, Class A orphans	GPR84 LGR5	8.90e-03	78	33	2	262
CoexpressionAtlas	dev gonad_e12.5_M_SertoliCell_Sox9_top-relative-expression-ranked_1000	TINAGL1 STIM1 ADORA1 SLC7A5 CLDN11 LGR5 ATP2B3 PRSS12 VCPKMT TTYH2	2.43e-06	884	38	10	gudmap_dev gonad_e12.5_M_SertoliCell_Sox9_1000
CoexpressionAtlas	dev gonad_e13.5_M_SertoliCell_Sox9_top-relative-expression-ranked_500	TINAGL1 STIM1 ADORA1 SLC7A5 CLDN11 LGR5 ATP2B3	1.02e-05	433	38	7	gudmap_dev gonad_e13.5_M_SertoliCell_Sox9_500
CoexpressionAtlas	DevelopingKidney_e15.5_S-shaped body_emap-27855_k-means-cluster#4_top-relative-expression-ranked_500	SLC17A1 PRSS12 CLDN10 TTYH2	1.91e-05	89	38	4	gudmap_developingKidney_e15.5_S-shaped body_500_k4
CoexpressionAtlas	DevelopingKidney_e15.5_S-shaped body_emap-27855_top-relative-expression-ranked_500	ADORA1 LGR5 SLC17A1 PRSS12 CLDN10 TTYH2	7.74e-05	406	38	6	gudmap_developingKidney_e15.5_S-shaped body_500
CoexpressionAtlas	dev gonad_e12.5_M_SertoliCell_Sox9_top-relative-expression-ranked_500	TINAGL1 STIM1 ADORA1 LGR5 ATP2B3 PRSS12	1.22e-04	441	38	6	gudmap_dev gonad_e12.5_M_SertoliCell_Sox9_500
CoexpressionAtlas	dev gonad_e13.5_M_SertoliCell_Sox9_top-relative-expression-ranked_1000	TINAGL1 STIM1 ADORA1 SLC7A5 CLDN11 LGR5 ATP2B3 VCPKMT	1.36e-04	880	38	8	gudmap_dev gonad_e13.5_M_SertoliCell_Sox9_1000
CoexpressionAtlas	dev gonad_e13.5_M_SertoliCell_Sox9_top-relative-expression-ranked_200	TINAGL1 STIM1 ADORA1 LGR5	2.37e-04	170	38	4	gudmap_dev gonad_e13.5_M_SertoliCell_Sox9_200
CoexpressionAtlas	DevelopingKidney_e15.5_S-shaped body_emap-27855_k-means-cluster#3_top-relative-expression-ranked_1000	SLC17A1 PRSS12 CLDN10 TTYH2	2.70e-04	176	38	4	gudmap_developingKidney_e15.5_S-shaped body_1000_k3
CoexpressionAtlas	dev gonad_e12.5_M_SertoliCell_Sox9_top-relative-expression-ranked_200	TINAGL1 STIM1 LGR5 ATP2B3	2.76e-04	177	38	4	gudmap_dev gonad_e12.5_M_SertoliCell_Sox9_200
Disease	factor VIII deficiency (is_marker_for)	C5 CFB	1.18e-05	4	42	2	DOID:12134 (is_marker_for)
Disease	androstenedione measurement, estrone measurement	OR4D1 CDK14	2.98e-04	18	42	2	EFO_0007970, EFO_0007972
Disease	vitamin B12 measurement	SLC25A2 SLC7A5P2	9.55e-04	32	42	2	EFO_0004620
Disease	Complement deficiency disease	C5 CFB	1.02e-03	33	42	2	C0272242
Disease	autism spectrum disorder (implicated_via_orthology)	SLC7A5 TMPRSS9 CASK	1.33e-03	152	42	3	DOID:0060041 (implicated_via_orthology)
Disease	Anorectal Malformations	STIM1 CASK	1.57e-03	41	42	2	C3495676
Disease	Hepatic fibrosis	TINAGL1 SLC24A4	2.23e-03	49	42	2	HP_0001395

Protein segments in the cluster

Peptide	Gene	Start	Entry
CEGIGAGLVDVAIWV	CTHRC1	201	Q96CG8
VAIAGCWILSFVVGL	ADORA1	126	P30542
WGVGCIFVEMIQGVA	CDK14	316	O94921
WAGASLCIIGGVIFC	CLDN10	166	P78369
CLFVGVGELVWGQVI	ATP2B3	1041	Q16720
IVDWAIQVCGGAGVS	ACAD11	721	Q709F0
GVCGLFAGQVVRLTW	SLC24A4	186	Q8NFF2
FIQVGVISWGVVDVC	CFB	711	P00751
GGVGCVVWDAAIVLS	VCPKMT	36	Q9H867
DVWGCGVILFILLSG	CASK	201	O14936
GRVEVFINGQWGTIC	PRSS12	511	P56730
AIVCAGVWILVLSGG	LPAR4	156	Q99677
QVCTVLVGIAWVGGF	OR4X2	131	Q8NGF9
LVVWAACGVFSIVGA	SLC7A5	86	Q01650
LVVWAACGVFSIVGA	SLC7A5P2	86	Q9GIP4
QHVCSLLVGVSWVGG	OR4C13	136	Q8NGP0
CVELVTGSWIGGIVN	OR5J2	141	Q8NH18
GIIQGIDSFVIWGCA	PRTN3	211	P24158
WGVVVAVTGTVGNVL	GPR84	26	Q9NQS5
QRIEALGGCVVWFGA	PPM1E	376	Q8WY54
CTGLIVASWVGGFVH	OR4D9	141	Q8NGE8
WMVVFAIGVCTGLVG	CLCN6	81	P51797
VGVGGFILVTLGCWF	COX20	61	Q5RI15
TWEIQGVGISNTGIC	C5	796	P01031
LQVVGFVTSFVGWIG	CLDN11	6	O75508
GWIGAVLCLVGGCVI	CLDN11	161	O75508
GGVGITCWILVCNKV	GET1	151	O00258
AIIAGIWAFCTGCGI	MC5R	161	P33032
VGSVLGQILVSVAGW	SLC19A2	171	O60779
WENGVGCHVIGFLSI	LGR5	631	O75473
CVGLVVAAWVGGFVH	OR4D1	141	Q15615
QLFIGGVTGWCTGFI	FUNDC2	86	Q9BWH2
CDIESFVLGVWGRVG	TINAGL1	446	Q9GZM7
AWGFTGVVAVLFCGI	SLC9A6	346	Q92581
VGGCQIIVSQGWVLI	TAAR8	186	Q969N4
FVLYGIVSWGAGCVQ	OVCH1	776	Q7RTY7
IGVAWVVVCRAVQGA	SLC17A1	131	Q14916
WGVVSVLVGTFIFGQ	SLC38A8	411	A6NNN8
LVVSIVIGVGGCWFA	STIM1	216	Q13586
GGVAGICLWLVVFPV	SLC25A2	216	Q9BXI2
GICLWNVLAGGVVAL	CLRN2	136	A0PK11
WTAVVAGLICCAAVG	TTYH2	91	Q9BSA4
YLAGIVSWGIGCAQV	TMPRSS9	701	Q7Z410
GTQCWVFGVIGFLEA	PTDSS1	351	P48651
AAVLVECGTVWGSGV	TYSND1	346	Q2T9J0