Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionlow-density lipoprotein particle receptor activity

OLR1 LRP2 LRP6

1.62e-04161363GO:0005041
GeneOntologyMolecularFunctioncargo receptor activity

MIA3 OLR1 MIA2 LRP2 LRP6

2.89e-04851365GO:0038024
GeneOntologyMolecularFunctionlipoprotein particle receptor activity

OLR1 LRP2 LRP6

3.76e-04211363GO:0030228
GeneOntologyMolecularFunctiontau-protein kinase activity

CSNK1D ROCK1 CDK5

4.33e-04221363GO:0050321
GeneOntologyMolecularFunctionenzyme-substrate adaptor activity

PRAMEF33 PRAMEF5 PRAMEF10 ANAPC7 PRAMEF6

4.83e-04951365GO:0140767
GeneOntologyMolecularFunctionnuclear retinoic acid receptor binding

PRAMEF33 PRAMEF5 PRAMEF10 PRAMEF6

5.36e-04551364GO:0042974
GeneOntologyBiologicalProcessGolgi vesicle transport

MIA3 ANKFY1 COPB1 BET1L TRAPPC8 SEC31B RAB4B MIA2 CSNK1D AP1G2 DOP1A

1.47e-0533913511GO:0048193
GeneOntologyBiologicalProcessregulation of Wnt signaling pathway involved in heart development

LRP6 ALPK2

4.25e-0521352GO:0003307
GeneOntologyBiologicalProcessnegative regulation of Wnt signaling pathway involved in heart development

LRP6 ALPK2

4.25e-0521352GO:0003308
GeneOntologyCellularComponentCul2-RING ubiquitin ligase complex

ZYG11A PRAMEF33 PRAMEF5 PRAMEF10 ZYG11B ZSWIM6 PRAMEF6

2.14e-08471367GO:0031462
GeneOntologyCellularComponentcullin-RING ubiquitin ligase complex

ZYG11A PRAMEF33 PRAMEF5 PRAMEF10 ZYG11B KLHL41 ZSWIM6 ANAPC7 PRAMEF6

1.05e-052121369GO:0031461
GeneOntologyCellularComponentubiquitin ligase complex

ZYG11A PRAMEF33 PRAMEF5 PRAMEF10 ZYG11B KLHL41 ZSWIM6 ANAPC7 PRAMEF6

5.05e-043521369GO:0000151
GeneOntologyCellularComponenttransferase complex

ZYG11A PRAMEF33 PRAMEF5 PRAMEF10 SLF1 IFIT5 ZYG11B KLHL41 ZSWIM6 RB1CC1 TRMT10C LAS1L DNA2 ANAPC7 PRAMEF6 CDK5

5.33e-0496313616GO:1990234
GeneOntologyCellularComponentintracellular protein-containing complex

ZYG11A PRAMEF33 PRAMEF5 PRAMEF10 WASHC4 RICTOR ZYG11B KLHL41 ZSWIM6 TRAPPC8 ECPAS TRMT10C LAS1L DNA2 ANAPC7 PRAMEF6

5.90e-0497213616GO:0140535
Domain-

ZYG11A COPB1 RICTOR ZYG11B ECPAS RANBP17 NF1 FHOD1 ASPM IPO13 AP1G2

6.43e-07222135111.25.10.10
DomainARM-like

ZYG11A COPB1 RICTOR ZYG11B ECPAS RANBP17 NF1 FHOD1 ASPM IPO13 AP1G2

4.32e-0627013511IPR011989
DomainARM-type_fold

ZYG11A COPB1 RICTOR ZYG11B ECPAS RANBP17 NF1 FHOD1 ASPM IPO13 AP1G2

3.62e-0533913511IPR016024
DomainPRAME_family

PRAMEF5 PRAMEF10 PRAMEF6

3.29e-04191353IPR026271
DomainAPC_su10/DOC_dom

MYCBP2 ZZEF1

1.06e-0371352IPR004939
DomainDOC

MYCBP2 ZZEF1

1.06e-0371352PS51284
DomainANAPC10

MYCBP2 ZZEF1

1.06e-0371352PF03256
DomainAPC10

MYCBP2 ZZEF1

1.06e-0371352SM01337
Domain-

ZYG11A PRAMEF5 PRAMEF10 ZYG11B RNH1 PHLPP1 PRAMEF6 NLRP13

2.34e-0332113583.80.10.10
DomainL_dom-like

ZYG11A PRAMEF5 PRAMEF10 ZYG11B RNH1 PHLPP1 PRAMEF6 NLRP13

2.68e-033281358IPR032675
DomainCyclin-like

CABLES2 ORC6 CASD1

3.69e-03431353IPR013763
DomainLdl_recept_b

LRP2 LRP6

4.46e-03141352PF00058
DomainLDLRB

LRP2 LRP6

4.46e-03141352PS51120
DomainClathrin/coatomer_adapt-like_N

COPB1 AP1G2

5.12e-03151352IPR002553
DomainRasGAP

GAPVD1 NF1

5.12e-03151352PF00616
DomainRAS_GTPASE_ACTIV_1

GAPVD1 NF1

5.12e-03151352PS00509
DomainLY

LRP2 LRP6

5.12e-03151352SM00135
DomainAdaptin_N

COPB1 AP1G2

5.12e-03151352PF01602
DomainIBN_N

RANBP17 IPO13

5.12e-03151352PF03810
DomainRAS_GTPASE_ACTIV_2

GAPVD1 NF1

5.12e-03151352PS50018
DomainLDLR_classB_rpt

LRP2 LRP6

5.12e-03151352IPR000033
DomainIBN_N

RANBP17 IPO13

5.82e-03161352SM00913
DomainBTB

ANKFY1 KLHL41 KLHL38 ZBTB5 KCTD18

6.15e-031601355PS50097
DomainImportin-beta_N

RANBP17 IPO13

6.57e-03171352IPR001494
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

GAPVD1 ANKFY1 MYCBP2 MCCC1 RB1CC1 ECPAS RLF NOL4L ZNF532 ARID5B LRP2 OBI1 ZMYM4

1.64e-084181401334709266
Pubmed

CRISPR-mediated gene targeting of CK1δ/ε leads to enhanced understanding of their role in endocytosis via phosphoregulation of GAPVD1.

GAPVD1 CSNK1D CSNK1E

6.38e-083140332321936
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

PRAMEF33 GAPVD1 MIA3 PRAMEF5 PRAMEF10 TEX2 UGGT1 RICTOR NEMP2 BMPR1A LARP4B NOL4L CSNK1E ARID5B GPC4 LRP2 ROCK1 DNA2 PRAMEF6

7.99e-0810841401911544199
Pubmed

Preferentially Expressed Antigen in Melanoma (PRAME) and the PRAME Family of Leucine-Rich Repeat Proteins.

PRAMEF33 PRAMEF5 PRAMEF10 PRAMEF6

1.16e-0620140426694250
Pubmed

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.

SLF1 ORC6 RICTOR HMGCS1 ZSWIM6 TRIP13 RLF NOL4L NF1 RNH1 ARID5B ASPM PHLPP1 LAS1L R3HDM1 OBI1 CRAMP1 ZMYM4 CDK5

1.69e-0613271401932694731
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

GAPVD1 WASHC4 TEX2 RRBP1 ECPAS ZZEF1 ZNF532 ZBTB5 IPO13 DNA2 CRAMP1 ZMYM4

1.70e-065291401214621295
Pubmed

Sertoli cell-only phenotype and scRNA-seq define PRAMEF12 as a factor essential for spermatogenesis in mice.

PRAMEF33 PRAMEF5 PRAMEF10 PRAMEF6

1.74e-0622140431729367
Pubmed

DUX is a non-essential synchronizer of zygotic genome activation.

PRAMEF33 PRAMEF5 PRAMEF10 PRAMEF6 USP17L8

1.80e-0650140531806660
Pubmed

Transcriptome analysis of mouse stem cells and early embryos.

PAPPA2 PRAMEF5 PRAMEF10 RB1CC1 ARID5B GPC4 ASPM ZBTB5 OBI1 PRAMEF6

2.34e-063631401014691545
Pubmed

MAGE-B4, a binding partner of PRAMEF12, is dispensable for spermatogenesis and male fertility in mice.

PRAMEF33 PRAMEF5 PRAMEF10 PRAMEF6

2.98e-0625140437451217
Pubmed

Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex.

PPP1R21 ANKFY1 WASHC4 UGGT1 SPAG9 HMGCS1 TRAPPC8 ECPAS ROCK1

4.26e-06304140932235678
Pubmed

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.

CABLES2 GAPVD1 STIM2 ANKFY1 WASHC4 RB1CC1 RRBP1 CMAS BMPR1A NF1 CSNK1D CSNK1E LAS1L ANAPC7 CDK5

4.32e-069101401536736316
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

WASHC4 COPB1 MYCBP2 VPS26C IFIT5 RRBP1 CMAS SEC31B OLR1 TXNDC11 MIA2 ZNF532 SACS ARID5B LRP2 ZBTB5 R3HDM1 ZMYM4

4.39e-0612851401835914814
Pubmed

Differences in gene expression between mouse and human for dynamically regulated genes in early embryo.

PRAMEF33 PRAMEF5 PRAMEF10 PRAMEF6

4.78e-0628140425089626
Pubmed

The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin.

NIBAN1 GAPVD1 TRIP13 LARP4B RAB4B RNH1 SACS FHOD1 ROCK1 LAS1L

5.51e-064001401035013556
Pubmed

Thirteen Ovary-Enriched Genes Are Individually Not Essential for Female Fertility in Mice.

PRAMEF33 PRAMEF5 PRAMEF10 PRAMEF6

6.35e-0630140438786026
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

MAGEA1 ANKFY1 WASHC4 COPB1 MYCBP2 RICTOR MCCC1 RRBP1 CMAS TRIP13 RLF NF1 RNH1 FHOD1 ASPM AP1G2 PRR14L LAS1L

8.88e-0613531401829467282
Pubmed

An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.

GAPVD1 MIA3 MYCBP2 TEX2 UGGT1 RRBP1 NCKAP5L LARP4B RNH1 CSNK1E ROCK1 PRR14L R3HDM1

9.00e-067331401334672954
Pubmed

A forward genetic screen in mice identifies mutants with abnormal cortical patterning.

MYCBP2 LRP2 LRP6

1.03e-0511140323968836
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

GAPVD1 STIM2 MYCBP2 TEX2 PARP8 RICTOR MCCC1 NCKAP5L NF1 CSNK1D CSNK1E R3HDM1 OBI1 DOP1A

1.07e-058611401436931259
Pubmed

Retinoic acid receptors are required for skeletal growth, matrix homeostasis and growth plate function in postnatal mouse.

PRAMEF33 PRAMEF5 PRAMEF10 PRAMEF6

1.20e-0535140419389355
Pubmed

Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.

GAPVD1 MIA3 PARP8 RICTOR ECPAS NCKAP5L PALS1 NF1 CSNK1E R3HDM1

1.42e-054461401024255178
Pubmed

The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted antiviral signaling and host translation.

STIM2 MIA3 MYCBP2 TEX2 UGGT1 SPAG9 MCCC1 TRAPPC8 LARP4B TRMT10C CSNK1D CSNK1E GPC4 R3HDM1 ZMYM4

1.43e-0510071401534597346
Pubmed

Regulation of cyclin-dependent kinase 5 catalytic activity by phosphorylation.

CSNK1D CDK5

1.61e-052140210500146
Pubmed

CK1δ and CK1ε are components of human 40S subunit precursors required for cytoplasmic 40S maturation.

CSNK1D CSNK1E

1.61e-052140224424021
Pubmed

Regulation of casein kinase I epsilon and casein kinase I delta by an in vivo futile phosphorylation cycle.

CSNK1D CSNK1E

1.61e-05214029632646
Pubmed

The mammalian formin FHOD1 is activated through phosphorylation by ROCK and mediates thrombin-induced stress fibre formation in endothelial cells.

FHOD1 ROCK1

1.61e-052140218239683
Pubmed

The ubiquitin ligase CRL2ZYG11 targets cyclin B1 for degradation in a conserved pathway that facilitates mitotic slippage.

ZYG11A ZYG11B

1.61e-052140227810909
Pubmed

Casein kinase I delta/epsilon phosphorylates topoisomerase IIalpha at serine-1106 and modulates DNA cleavage activity.

CSNK1D CSNK1E

1.61e-052140219043076
Pubmed

Effects of altered expression and activity levels of CK1δ and ɛ on tumor growth and survival of colorectal cancer patients.

CSNK1D CSNK1E

1.61e-052140225404202
Pubmed

Structure of the TCR expressed on a gastritogenic T cell clone, II-6, and frequent appearance of similar clonotypes in mice bearing autoimmune gastritis.

ATP4A IL6

1.61e-05214029466312
Pubmed

An evaluation of polymorphisms in casein kinase 1 delta and epsilon genes in major psychiatric disorders.

CSNK1D CSNK1E

1.61e-052140222981886
Pubmed

TANGO1 builds a machine for collagen export by recruiting and spatially organizing COPII, tethers and membranes.

MIA3 MIA2

1.61e-052140229513218
Pubmed

A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.

GAPVD1 WASHC4 COPB1 NDE1 DUSP7 RICTOR NCKAP5L LARP4B CSNK1D CSNK1E AP1G2 LAS1L R3HDM1 ANAPC7 OBI1

2.04e-0510381401526673895
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

STIM2 C8orf88 MRPL47 PCDHGA10 PARP8 UGGT1 IFIT5 RRBP1 TRIP13 TASOR2 BMPR1A MIA2 SACS GPC4 ASPM ANAPC7 OBI1 DOP1A

2.08e-0514421401835575683
Pubmed

Virus-Host Interactome and Proteomic Survey Reveal Potential Virulence Factors Influencing SARS-CoV-2 Pathogenesis.

MIA3 COPB1 NDE1 MYCBP2 UGGT1 CMAS TXNDC11 RNH1

2.16e-05285140832838362
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

STIM2 MIA3 MYCBP2 PODXL UGGT1 RRBP1 ZZEF1 TXNDC11 BMPR1A NF1 MIA2 CELSR2 FHOD1 IPO13 LRP6 R3HDM1

2.86e-0512011401635696571
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

STIM2 MIA3 MYCBP2 MRPL47 TEX2 UGGT1 RICTOR RB1CC1 TRAPPC8 RRBP1 CMAS NCKAP5L TRMT10C SACS CSNK1E ASPM LAS1L DNA2

3.11e-0514871401833957083
Pubmed

Myosin-X recruits lamellipodin to filopodia tips.

MAGEA1 MYCBP2 TRMT10C RNH1 SACS

3.11e-0589140536861887
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

CABLES2 MIA3 DYM MYCBP2 ZSWIM6 RRBP1 ECPAS TRIP13 TASOR2 RLF RANBP17 ZNF532 CSNK1D ARID5B CDYL2 CRAMP1 ZMYM4 DOP1A

3.17e-0514891401828611215
Pubmed

A High-Density Human Mitochondrial Proximity Interaction Network.

STIM2 MIA3 MYCBP2 MRPL47 TEX2 SPAG9 RRBP1 CMAS ZZEF1 LARP4B TRMT10C MIA2 CSNK1D CSNK1E LRP2 LAS1L R3HDM1 ANAPC7

3.37e-0514961401832877691
Pubmed

Amerindian-specific regions under positive selection harbour new lipid variants in Latinos.

DLGAP2 CELSR2 RORA

3.44e-0516140324886709
Pubmed

Differential expression of PRAMEL1, a cancer/testis antigen, during spermatogenesis in the mouse.

PRAMEF5 PRAMEF10 PRAMEF6

4.17e-0517140323565261
Pubmed

Mouse Pramel1 regulates spermatogonial development by inhibiting retinoic acid signaling during spermatogenesis.

PRAMEF5 PRAMEF10 PRAMEF6

4.17e-0517140337781892
Pubmed

Global Interactome Mapping of Mitochondrial Intermembrane Space Proteases Identifies a Novel Function for HTRA2.

MRPL47 UGGT1 RICTOR ZZEF1 TRMT10C COMMD4 RNH1 LAS1L ANAPC7 ZMYM4

4.79e-055151401031617661
Pubmed

The Diaphanous-related Formin FHOD1 associates with ROCK1 and promotes Src-dependent plasma membrane blebbing.

FHOD1 ROCK1

4.81e-053140218694941
Pubmed

TANGO1 and Mia2/cTAGE5 (TALI) cooperate to export bulky pre-chylomicrons/VLDLs from the endoplasmic reticulum.

MIA3 MIA2

4.81e-053140227138255
Pubmed

Centrosomal anchoring of the protein kinase CK1delta mediated by attachment to the large, coiled-coil scaffolding protein CG-NAP/AKAP450.

CSNK1D CSNK1E

4.81e-053140212270714
Pubmed

Gene expression levels of Casein kinase 1 (CK1) isoforms are correlated to adiponectin levels in adipose tissue of morbid obese patients and site-specific phosphorylation mediated by CK1 influences multimerization of adiponectin.

CSNK1D CSNK1E

4.81e-053140225724478
Pubmed

A comparative study of structural and conformational properties of casein kinase-1 isoforms: insights from molecular dynamics and principal component analysis.

CSNK1D CSNK1E

4.81e-053140225665722
Pubmed

Cell cycle-dependent ubiquitylation and destruction of NDE1 by CDK5-FBW7 regulates ciliary length.

NDE1 CDK5

4.81e-053140226206584
Pubmed

Casein kinase 1-epsilon or 1-delta required for Wnt-mediated intestinal stem cell maintenance.

CSNK1D CSNK1E

4.81e-053140228963394
Pubmed

Human Rad17 C-terminal tail is phosphorylated by concerted action of CK1δ/ε and CK2 to promote interaction with the 9-1-1 complex.

CSNK1D CSNK1E

4.81e-053140231353086
Pubmed

Sequence analysis of the cDNA for the human casein kinase I delta (CSNK1D) gene and its chromosomal localization.

CSNK1D CSNK1E

4.81e-05314028786104
Pubmed

Disturbed expression of vitamin D and retinoic acid-related orphan receptors α and γ and of megalin in inflammatory skin diseases.

LRP2 RORA

4.81e-053140234995387
Pubmed

Targeting of the circadian clock via CK1δ/ε to improve glucose homeostasis in obesity.

CSNK1D CSNK1E

4.81e-053140227439882
Pubmed

Dual function of cTAGE5 in collagen export from the endoplasmic reticulum.

MIA3 MIA2

4.81e-053140227170179
Pubmed

Genetic Study of IL6, GDF5 and PAPPA2 in Association with Developmental Dysplasia of the Hip.

PAPPA2 IL6

4.81e-053140234203285
Pubmed

CKIepsilon/delta-dependent phosphorylation is a temperature-insensitive, period-determining process in the mammalian circadian clock.

CSNK1D CSNK1E

4.81e-053140219805222
Pubmed

Distinct isoform-specific complexes of TANGO1 cooperatively facilitate collagen secretion from the endoplasmic reticulum.

MIA3 MIA2

4.81e-053140227413011
Pubmed

Casein kinase 1 proteomics reveal prohibitin 2 function in molecular clock.

CSNK1D CSNK1E

4.81e-053140222384121
Pubmed

RORα suppresses interleukin-6-mediated hepatic acute phase response.

RORA IL6

4.81e-053140231409825
Pubmed

CK1δ activity is modulated by CDK2/E- and CDK5/p35-mediated phosphorylation.

CSNK1D CDK5

4.81e-053140226464264
Pubmed

The promoter of the oocyte-specific gene, Oog1, functions in both male and female meiotic germ cells in transgenic mice.

PRAMEF5 PRAMEF10 PRAMEF6

4.98e-0518140323894331
Pubmed

Pramel15 facilitates zygotic nuclear DNMT1 degradation and DNA demethylation.

PRAMEF5 PRAMEF10 PRAMEF6

4.98e-0518140339181896
Pubmed

Oogenesin is a novel mouse protein expressed in oocytes and early cleavage-stage embryos.

PRAMEF5 PRAMEF10 PRAMEF6

4.98e-0518140312890732
Pubmed

Oocyte-specific gene Oog1 suppresses the expression of spermatogenesis-specific genes in oocytes.

PRAMEF5 PRAMEF10 PRAMEF6

4.98e-0518140329731491
Pubmed

Identification of a new expanding family of genes characterized by atypical LRR domains. Localization of a cluster preferentially expressed in oocyte.

PRAMEF5 PRAMEF10 PRAMEF6

4.98e-0518140314675769
Pubmed

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.

DYM WASHC4 MYCBP2 UGGT1 VPS26C ZYG11B ECPAS LARP4B RNH1 IPO13 R3HDM1 DNA2

5.75e-057541401233060197
Pubmed

Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.

DLGAP2 STIM2 MIA3 MYCBP2 TEX2 RICTOR HMGCS1 MCCC1 RRBP1 CMAS LARP4B TRMT10C NF1 CELSR2 CSNK1E

5.86e-0511391401536417873
Pubmed

Pramel7 mediates ground-state pluripotency through proteasomal-epigenetic combined pathways.

PRAMEF5 PRAMEF10 PRAMEF6

5.90e-0519140328604677
Pubmed

PROTAC-mediated degradation reveals a non-catalytic function of AURORA-A kinase.

GAPVD1 MYCBP2 ZZEF1 LARP4B ASPM ANAPC7 OBI1

6.74e-05247140732989298
Pubmed

Systematic analysis of human protein complexes identifies chromosome segregation proteins.

GAPVD1 WASHC4 COPB1 NDE1 MRPL47 SPAG9 RRBP1 TASOR2 BMPR1A CSNK1E ASPM ANAPC7 OBI1 ZMYM4 CDK5

6.85e-0511551401520360068
Pubmed

Oog1, an oocyte-specific protein, interacts with Ras and Ras-signaling proteins during early embryogenesis.

PRAMEF5 PRAMEF10 PRAMEF6

6.92e-0520140316580637
Pubmed

Pramel7 mediates LIF/STAT3-dependent self-renewal in embryonic stem cells.

PRAMEF5 PRAMEF10 PRAMEF6

6.92e-0520140321425410
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

GAPVD1 COPB1 MYCBP2 UGGT1 SPAG9 ECPAS TASOR2 LARP4B NF1 RNH1 LAS1L

7.16e-056531401122586326
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

FILIP1 GAPVD1 MYCBP2 RICTOR SPAG9 RRBP1 ECPAS NOL4L NF1 CSNK1E FHOD1 ZMYM4

7.37e-057741401215302935
Pubmed

Defining the membrane proteome of NK cells.

PPP1R21 NIBAN1 MIA3 COPB1 NDE1 MYCBP2 ORC6 BET1L ECPAS CMAS LARP4B NF1 MIA2 FHOD1 LAS1L

7.76e-0511681401519946888
Pubmed

Involvement of casein kinase 1 epsilon/delta (Csnk1e/d) in the pathogenesis of familial Parkinson's disease caused by CHCHD2.

CSNK1D CSNK1E

9.60e-054140237578019
Pubmed

cTAGE5 mediates collagen secretion through interaction with TANGO1 at endoplasmic reticulum exit sites.

MIA3 MIA2

9.60e-054140221525241
Pubmed

The DNA-binding activity of mouse DNA methyltransferase 1 is regulated by phosphorylation with casein kinase 1delta/epsilon.

CSNK1D CSNK1E

9.60e-054140220192920
Pubmed

Concentration of Sec12 at ER exit sites via interaction with cTAGE5 is required for collagen export.

MIA3 MIA2

9.60e-054140225202031
Pubmed

Therapeutic Targeting of Casein Kinase 1δ/ε in an Alzheimer's Disease Mouse Model.

CSNK1D CSNK1E

9.60e-054140231334659
Pubmed

TANGO1/cTAGE5 receptor as a polyvalent template for assembly of large COPII coats.

MIA3 MIA2

9.60e-054140227551091
Pubmed

Casein kinase 1 delta (CK1delta) regulates period length of the mouse suprachiasmatic circadian clock in vitro.

CSNK1D CSNK1E

9.60e-054140220421981
Pubmed

Involvement of casein kinase Iepsilon in cytokine-induced granulocytic differentiation.

CSNK1D CSNK1E

9.60e-054140215070676
Pubmed

CK1δ/ε protein kinase primes the PER2 circadian phosphoswitch.

CSNK1D CSNK1E

9.60e-054140229784789
Pubmed

Casein kinase 1 delta functions at the centrosome to mediate Wnt-3a-dependent neurite outgrowth.

CSNK1D CSNK1E

9.60e-054140221422228
Pubmed

R-Ras subfamily proteins elicit distinct physiologic effects and phosphoproteome alterations in neurofibromin-null MPNST cells.

NF1 ROCK1

9.60e-054140234530870
Pubmed

p53 is phosphorylated in vitro and in vivo by the delta and epsilon isoforms of casein kinase 1 and enhances the level of casein kinase 1 delta in response to topoisomerase-directed drugs.

CSNK1D CSNK1E

9.60e-05414029349507
Pubmed

Isolation and characterization of human casein kinase I epsilon (CKI), a novel member of the CKI gene family.

CSNK1D CSNK1E

9.60e-05414027797465
Pubmed

The nuclear receptor ROR(alpha) exerts a bi-directional regulation of IL-6 in resting and reactive astrocytes.

RORA IL6

9.60e-054140219955433
Pubmed

Syndecan-1 (CD138) modulates triple-negative breast cancer stem cell properties via regulation of LRP-6 and IL-6-mediated STAT3 signaling.

LRP6 IL6

9.60e-054140224392029
Pubmed

Oogenesis specific genes (Nobox, Oct4, Bmp15, Gdf9, Oogenesin1 and Oogenesin2) are differentially expressed during natural and gonadotropin-induced mouse follicular development.

PRAMEF5 PRAMEF10 PRAMEF6

1.07e-0423140319480014
Pubmed

Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis.

GAPVD1 STIM2 MIA3 TEX2 BET1L IFIT5 SPAG9 TRAPPC8 RRBP1 PRR14L

1.07e-045681401037774976
Pubmed

The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.

STIM2 PODXL RICTOR OLR1 KLHL38 PALS1 AFAP1L2 NF1 CELSR2 ROCK1

1.09e-045691401030639242
Pubmed

TRIM65 regulates microRNA activity by ubiquitination of TNRC6.

IFIT5 TRIP13 LARP4B ASPM PRR14L LAS1L DNA2 OBI1

1.20e-04364140824778252
Pubmed

Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei.

PRAMEF5 PRAMEF10 PRAMEF6

1.38e-0425140312620990
Pubmed

Expression profiling in transgenic FVB/N embryonic stem cells overexpressing STAT3.

PRAMEF5 PRAMEF10 PRAMEF6

1.55e-0426140318500982
Pubmed

SNX27-driven membrane localisation of OTULIN antagonises linear ubiquitination and NF-κB signalling activation.

ANKFY1 WASHC4 TMEM45A RICTOR ARID5B ZBTB5 PHLPP1 ROCK1

1.55e-04378140834315543
Cytoband1p36.21

PRAMEF33 PRAMEF5 PRAMEF10 PRAMEF6

4.29e-056314041p36.21
Cytoband7p21

IL6 DNAH11

1.37e-04614027p21
GeneFamilyZYG11 cell cycle regulator family

ZYG11A ZYG11B

6.53e-0538526
GeneFamilyPRAME family

PRAMEF5 PRAMEF10 PRAMEF6

1.89e-0424853686
GeneFamilyLow density lipoprotein receptors

LRP2 LRP6

1.65e-0313852634
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_DN

GAPVD1 WASHC4 MYCBP2 PODXL SPAG9 RB1CC1 TRAPPC8 ZZEF1 RLF BMPR1A LARP4B MIA2 SACS ARID5B PHLPP1 ROCK1 R3HDM1 ZMYM4

6.12e-0785613818M4500
CoexpressionGSE27786_CD4_TCELL_VS_ERYTHTROBLAST_UP

PPP1R21 MIA3 RLF CSNK1D CSNK1E FHOD1 RORA ZMYM4

1.14e-052001388M4827
CoexpressionGSE27786_LSK_VS_CD4_TCELL_DN

STIM2 MIA3 NRAP VPS26C RICTOR BBS9 MIA2 ROCK1

1.14e-052001388M4747
CoexpressionVANTVEER_BREAST_CANCER_METASTASIS_DN

TMEM45A ORC6 MCCC1 TRIP13 SACS ASPM

2.48e-051091386M9826
CoexpressionNUYTTEN_EZH2_TARGETS_UP

MIA3 ANKFY1 WASHC4 GCNT3 TMEM45A PODXL PARP8 IFIT5 SPAG9 HMGCS1 RRBP1 RLF PALS1 ARID5B ZFYVE26 L3HYPDH IL6

3.18e-05103313817M4196
CoexpressionHAMAI_APOPTOSIS_VIA_TRAIL_UP

SLF1 MYCBP2 PODXL RB1CC1 TRAPPC8 TASOR2 RLF TRMT10C SACS RAD54B ASPM RORA OBI1

4.53e-0565613813M18979
ToppCellSigmoid-(1)_T_cell-(18)_cycling_gd_T|Sigmoid / shred on region, Cell_type, and subtype

CABLES2 ORC6 TRAPPC8 PKD1L3 TRIP13 AFAP1L2 ASPM ZFYVE26 DNA2

1.50e-0820014096e367abd1a4b87e20eb9095b8337723163e8bbae
ToppCellSigmoid-T_cell-cycling_gd_T|Sigmoid / Region, Cell class and subclass

CABLES2 ORC6 TRAPPC8 PKD1L3 TRIP13 AFAP1L2 ASPM ZFYVE26 DNA2

1.50e-0820014099769185abae084ffac36420c749625e679b70ca8
ToppCellSigmoid-T_cell-cycling_gd_T|T_cell / Region, Cell class and subclass

CABLES2 TRAPPC8 PKD1L3 TRIP13 AFAP1L2 ASPM ZFYVE26 DNA2

2.40e-0720014084e489ecf472857357d45e9f6c7a812aa48b72ebf
ToppCellCOVID-19_Mild-Neu_3|COVID-19_Mild / 5 Neutrophil clusters in COVID-19 patients

ANKFY1 PARP8 FHOD1 AP1G2 RORA PRR14L ZMYM4

1.44e-0617614072049767fd591045cfcf5b1071d80798e52843f27
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8|GI_small-bowel / Manually curated celltypes from each tissue

RICTOR HMGCS1 RB1CC1 TASOR2 RLF NF1 RORA

2.24e-061881407ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell3'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)-|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TMEM45A CYP2F1 ORC6 PODXL BET1L LAS1L

1.76e-0517214065401ac7739f95fb8681cfb4747ab6e447a3c2ae8
ToppCell3'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TMEM45A CYP2F1 ORC6 PODXL BET1L LAS1L

1.76e-051721406b3da7f488d191214d7bb74fbac189fe8c29ee6cd
ToppCell3'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TMEM45A CYP2F1 ORC6 PODXL BET1L LAS1L

1.76e-05172140674dd4a7acb2cf857fed20219e4d7dc1adfbaa398
DiseaseCharlevoix-Saguenay spastic ataxia (implicated_via_orthology)

ANKFY1 SACS

2.05e-0521342DOID:0050946 (implicated_via_orthology)
Diseasebrain disease (implicated_via_orthology)

STIM2 MYCBP2

3.03e-0461342DOID:936 (implicated_via_orthology)
Diseaseaortic stenosis

BET1L CELSR2 IL6

3.75e-04311343EFO_0000266
DiseaseJuvenile-Onset Still Disease

BEND2 OLR1 SLC22A16 RNF103 IL6

3.87e-041351345C0087031
DiseaseLDL cholesterol change measurement

PKD1L3 CELSR2

4.24e-0471342EFO_0007804
Diseasesyndromic X-linked intellectual disability Najm type (implicated_via_orthology)

CSNK1D CSNK1E

4.24e-0471342DOID:0060807 (implicated_via_orthology)
Diseaseeye colour measurement

GAPVD1 MYCBP2 ZSWIM6 ARID5B LRP2 RORA

4.97e-042181346EFO_0009764
Diseasestanniocalcin-1 measurement

LARP4B CELSR2

5.63e-0481342EFO_0020753
DiseaseSchizophrenia

ANKK1 DLGAP2 DYM NDE1 RB1CC1 PTGER3 CFAP65 PRODH2 CSNK1E LRP2 IL6 CDK5

7.17e-0488313412C0036341
Diseasephosphatidylethanolamine measurement

SYCP2L GCNT3 CMAS ZZEF1 RORA

1.19e-031731345EFO_0010228
Diseasecholesteryl ester 24:5 measurement

SYCP2L AXDND1

1.31e-03121342EFO_0021448
Diseaseresponse to trauma exposure

BBS9 RORA DNAH11

1.63e-03511343EFO_0008483
Diseasemembranous glomerulonephritis (biomarker_via_orthology)

PTGER3 LRP2

1.80e-03141342DOID:10976 (biomarker_via_orthology)
Diseaseinsulin metabolic clearance rate measurement, glucose homeostasis measurement

ZZEF1 SLC22A16

1.80e-03141342EFO_0006830, EFO_0006896
DiseasePolyarthritis, Juvenile, Rheumatoid Factor Positive

BEND2 OLR1 SLC22A16 RNF103

3.05e-031311344C4704862
DiseasePolyarthritis, Juvenile, Rheumatoid Factor Negative

BEND2 OLR1 SLC22A16 RNF103

3.05e-031311344C4552091
DiseaseJuvenile arthritis

BEND2 OLR1 SLC22A16 RNF103

3.05e-031311344C3495559
DiseaseJuvenile psoriatic arthritis

BEND2 OLR1 SLC22A16 RNF103

3.05e-031311344C3714758
Diseaseblood metabolite measurement

PRODH2 SLC22A16

3.33e-03191342EFO_0005664
Diseaseneoplasm of mature B-cells

CXCR5 PHLPP1

3.69e-03201342EFO_0000096
Diseasealpha-tocopherol measurement

VPS26C IL6

3.69e-03201342EFO_0007898
DiseaseSeckel syndrome

ORC6 DNA2

4.46e-03221342C0265202
Diseasedepressive disorder (implicated_via_orthology)

RNF103 CDK5

4.46e-03221342DOID:1596 (implicated_via_orthology)
DiseasePrimary microcephaly

NDE1 ASPM

4.46e-03221342C0431350
Diseasee-selectin measurement

CELSR2 GBGT1

4.46e-03221342EFO_0004575
Diseasetotal blood protein measurement

CABLES2 TTC41P RRBP1 ARID5B ROCK1 RORA IL6

4.53e-034491347EFO_0004536

Protein segments in the cluster

PeptideGeneStartEntry
KVAATLKTLVLKDCR

PRAMEF33

346

A0A0G2JMD5
AVSEKKILLEALTCS

TRHDE

881

Q9UKU6
LDTLARLKAVDNTCK

CXCR5

281

P32302
LSGATIKSTKELLCR

ALPK2

1061

Q86TB3
SSALREICLLKELKH

CDK5

46

Q00535
SKALARKVSCKLSLR

ANKK1

301

Q8NFD2
DSLASKVTRLKSLAL

BET1L

26

Q9NYM9
LSSTALVKKSCLAEL

AFAP1L2

26

Q8N4X5
CLKLIASSRFTDKRV

AP1G2

71

O75843
KDLQSRLSLCEKALA

DNAH11

1601

Q96DT5
KDALAKLSTLVSRAL

BTBD11

126

A6QL63
LVSKAEELLKSRCSS

DLGAP2

701

Q9P1A6
LSELTDSLRLCSKIL

DOP1A

526

Q5JWR5
VLSKEVRKALKLACS

CELSR2

2611

Q9HCU4
KTCCLLAILLKTTNR

ASPM

3371

Q8IZT6
SALDKITASLCDLKS

HMGCS1

396

Q01581
KVTALTSTRLCKELA

PRODH2

236

Q9UF12
KSSSKLKLVRSLAVC

R3HDM1

71

Q15032
IKTTTALISLSCEKR

RAD54B

441

Q9Y620
RDTSLKDVLVLACSL

RANBP17

181

Q9H2T7
AFLKCARTILNKIDS

RAB4B

161

P61018
VCLLLTLSSRDKGKL

CYP2F1

16

P24903
RKCLHSIKLKDSILS

SPAG9

991

O60271
ISTICSLEKKSLLRD

ANAPC7

221

Q9UJX3
RDFLLKLSSVSICRK

C8orf88

81

P0DMB2
KLAETEKRCALLAAQ

ANKFY1

26

Q9P2R3
LKLKVSDLSDTRCKL

RB1CC1

1046

Q8TDY2
ASDEKLISLICRAVK

PODXL

371

O00592
VKSEECLTLKSHRLL

PARP8

371

Q8N3A8
SCILESLFRAVITKK

MAGEA1

91

P43355
CLTKVELAKSRLAGA

NCKAP5L

771

Q9HCH0
TSLAEDLRLSCAKKA

NRAP

1146

Q86VF7
LSAALLAAELKSKSC

GPC4

16

O75487
LAAELKSKSCSEVRR

GPC4

21

O75487
RSLLLVNKDCKLLTF

CFAP65

796

Q6ZU64
KKKLRLALCSADSVA

GAPVD1

1121

Q14C86
KKTLEFCLSRENLAS

LARP4B

161

Q92615
VLTLAKTKSCASLSA

BEND2

676

Q8NDZ0
RKAAELALKTLSKVC

ECPAS

1221

Q5VYK3
KKLKRFIAIIAVSCS

HTD2

131

P86397
NRSKESKDCSGLVLL

PCDHGA10

6

Q9Y5H3
ATIKALVSRCRAKAT

PTGER3

251

P43115
AAAAALSVRRCKALK

NEMP2

26

A6NFY4
IRGSTLRFLCKLKEA

COPB1

116

P53618
CSRKFSLKTVLLLAD

CSNK1D

96

P48730
CKSSLFLKLVRDKLQ

FMO4

531

P31512
EKSGLCLSKRLNSIR

OBI1

501

Q5W0B1
ASCLATRLNLFKLSK

KLHL41

591

O60662
KTCKDGATELLLLAR

LRP6

321

O75581
LAVASTADLIRCKLL

LAS1L

86

Q9Y4W2
EASLCRIKVSKAAAD

GNG3

26

P63215
RTCKVTASESLLLLV

LRP2

1426

P98164
CRALSKRLALAEKSK

PPP1R21

696

Q6ZMI0
ILAAACESETRKAAK

NOL4L

271

Q96MY1
KCLSLDAKLLKINST

OLR1

171

P78380
ILSKILTAATDACRL

RICTOR

716

Q6R327
SQLKKHITLLCDRLS

BBS9

806

Q3SYG4
LSRKKVIAFTLCAAR

OR2D2

86

Q9H210
TSLCKALAQKLTIRL

TRIP13

186

Q15645
KICLLSLRTQSLKTL

PALS1

571

Q8N3R9
LRSNIELKKALTDFC

KCTD18

116

Q6PI47
SLCTDRVKKATILIS

PAPPA2

341

Q9BXP8
LTSALKKLSTKRLCH

IFIT5

416

Q13325
LACSALKKTYRDILT

IDNK

81

Q5T6J7
KDNSSLLKRLACIAA

CASD1

766

Q96PB1
KLIRFSTLDKDISCL

GBGT1

331

Q8N5D6
FLSRTKELKLSAECQ

DYM

81

Q7RTS9
SCSHLKSDLVRIKRL

FRMPD2B

111

Q6IN97
CSCLLSNIKGRKITL

AXDND1

806

Q5T1B0
KQRLLSCLLKLISTE

CRAMP1

726

Q96RY5
LLATVALKLSFRLKC

GCNT3

21

O95395
LKCATLDTRALLKLA

BMPR1A

321

P36894
KERFATRCKAATVLL

DUSP7

121

Q16829
TLAKMSSVKLRLLCS

COMMD4

21

Q9H0A8
LLLSRKAAAKESLCQ

MCCC1

496

Q96RQ3
KTACSLDARTETLLL

C4orf48

66

Q5BLP8
CASLSRLVVKTALKL

FHOD1

211

Q9Y613
EICRSKSIKSLALLE

DNA2

716

P51530
VALSFKKLKTILECR

RNF103

41

O00237
ACLRSSILLSLIDEK

SACS

2181

Q9NZJ4
SKIVLTRLCVALASL

IPO13

116

O94829
VTVCLSLTAKRLASK

ATP4A

351

P20648
CVLLAAKISSDLRKS

CABLES2

411

Q9BTV7
LDGISALRKETCNKS

IL6

61

P05231
CLVAESAVSKLLLSA

PRR14L

1956

Q5THK1
LLAISLTKCLESTKL

MIA2

11

Q96PC5
LKLRASVSTKCNLED

MIA3

1476

Q5JRA6
SSELSCSVDLLKKRL

FILIP1

586

Q7Z7B0
ERACSKQTLSSLKLD

CMAS

326

Q8NFW8
DDLCKFKSLIRTVSL

NLRP2B

21

P0DMW2
RASSCKLSELLSLDL

SLC22A16

316

Q86VW1
SKQLASVKALRKCSD

SNTN

41

A6NMZ2
RKCSDLEKAIATTAL

SNTN

51

A6NMZ2
QTKRILALLAKCSSS

PKD1L3

1231

Q7Z443
NLEKLAERFLAKTCS

SRGAP2B

66

P0DMP2
TSKLAECIGKTRTLL

MYCBP2

1491

O75592
TSAALLSACKILKLK

ORC6

141

Q9Y5N6
LQRCSLSATDLKTKR

SEC31B

1086

Q9NQW1
LALLCRRVSSALKSS

MRPL47

6

Q9HD33
TAEKLGLDICSAKTR

L3HYPDH

196

Q96EM0
LISKKKLIARDDLCS

ARID5B

716

Q14865
LEESKCLVRSFLKSV

CDYL2

456

Q8N8U2
DQLLSCLKTSLKVLT

PRAMEF6

286

Q5VXH4
KLSSCIAAIAALSAK

ZNF532

266

Q9HCE3
ITALLACKDRLKSLT

ZYG11B

201

Q9C0D3
RASADVLSKCKKALS

ZBTB5

586

O15062
SCSLRKFSTLKKLVL

UBTFL6

71

P0CB48
RKEESSALLLNSCKI

ZNF549

161

Q6P9A3
LATAEQACKEKLLSL

RRBP1

1031

Q9P2E9
LSALKEECRALTKGL

NIBAN1

291

Q9BZQ8
ATALSKLCAESKEIS

RLF

231

Q13129
ILTKLICKVSTLRAL

RORA

466

P35398
AKKALSELTTCLRER

STIM2

416

Q9P246
VAISEALCRLTIKKS

SYCP2L

231

Q5T4T6
DQLLSCLKTSLKVLT

PRAMEF5

286

Q5TYX0
LRKQLSISLSDTLCK

TTC41P

1036

Q6P2S7
LALKDFCSTKIKREL

USP29

336

Q9HBJ7
SRCSLKHRKSLLLTD

NF1

2451

P21359
KVAATLKTLVLKDCR

PRAMEF10

346

O60809
LCRVLRAKESLKELS

RNH1

276

P13489
LIAERLCKSEKFLAA

SLF1

46

Q9BQI6
LLDLNLAKCSSSLKK

SLF1

761

Q9BQI6
SKEAKNLICAFLTDR

ROCK1

306

Q13464
TRELCIKLDSSKELL

TSGA10

511

Q9BZW7
LLLALKFTCSRAKDV

TXNDC11

76

Q6PKC3
KSVKCATVLSDILRR

ZSWIM6

1096

Q9HCJ5
TSVKALCRLVELLKA

WASHC4

471

Q2M389
REFSVLTELLKKLCS

ZZEF1

1056

O43149
LAERCVLLSAELLKS

TRAPPC8

501

Q9Y2L5
TSAKVLILVLKRFCD

USP17L8

271

P0C7I0
SLCTRSLDRKTLLLK

PHLPP1

166

O60346
LSTLNCALLETKKSL

TASOR2

181

Q5VWN6
DSRSSTKAEILKCLL

TASOR2

2361

Q5VWN6
KTSSLVLEKCSLSAL

TEX2

396

Q8IWB9
LKRLCSSEVGLLKNA

TMEM45A

251

Q9NWC5
LVTDISALLTCKDRL

ZYG11A

216

Q6WRX3
SALLTCKDRLKSLTM

ZYG11A

221

Q6WRX3
AFLKSRSKLLATVAC

ZFYVE26

1306

Q68DK2
TSLAKAKRLNLATEC

TRMT10C

321

Q7L0Y3
VRSIKLKEDILSCTF

ZMYM4

1266

Q5VZL5
KKTCESDTLEALLLT

UGGT1

156

Q9NYU2
RSLLAKDLTKTCEFI

VPS26C

126

O14972
DCSTKESSLLLIRDK

KLRB1

121

Q12918
CSRKFSLKTVLLLAD

CSNK1E

96

P49674
RLSEILSCETLKKKA

KLHL38

141

Q2WGJ6
CKRLNKLRLSVSSHI

NLRP13

681

Q86W25
LRKVGALESKLASCR

NDE1

261

Q9NXR1