Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionstructural constituent of chromatin

H3C1 H3-3A H3Y1 H3-4 H3C15

8.94e-05100905GO:0030527
GeneOntologyBiologicalProcesschromatin organization

MTA2 MYD88 SAMD1 LRWD1 UBE2A UBE2B L3MBTL1 H3C1 TRIM28 H3-3A LSM11 INO80 H3-4 H3C15

2.83e-058968914GO:0006325
GeneOntologyCellularComponentchromatin

MTA2 TGIF1 LRWD1 VENTX UBE2A UBE2B PRAMEF5 L3MBTL1 H3C1 TRIM28 H3-3A INO80 H3Y1 PRAMEF18 H3-4 PRAMEF13 H3C15 TFCP2

5.93e-0514809118GO:0000785
GeneOntologyCellularComponentHULC complex

UBE2A UBE2B

1.12e-044912GO:0033503
GeneOntologyCellularComponentubiquitin ligase complex

TRPC4AP UBE2A UBE2B PRAMEF5 TMEM183A CDC26 PRAMEF18 PRAMEF13

1.51e-04352918GO:0000151
GeneOntologyCellularComponentcullin-RING ubiquitin ligase complex

TRPC4AP PRAMEF5 TMEM183A CDC26 PRAMEF18 PRAMEF13

3.30e-04212916GO:0031461
GeneOntologyCellularComponentnucleosome

H3C1 H3-3A H3Y1 H3-4 H3C15

3.44e-04138915GO:0000786
GeneOntologyCellularComponentubiquitin conjugating enzyme complex

UBE2A UBE2B

6.61e-049912GO:0031371
GeneOntologyCellularComponentsex chromosome

UBE2A UBE2B H3-3A

9.29e-0444913GO:0000803
GeneOntologyCellularComponentCul2-RING ubiquitin ligase complex

PRAMEF5 PRAMEF18 PRAMEF13

1.13e-0347913GO:0031462
GeneOntologyCellularComponentkinesin complex

KIF15 KIF13A KIF1C

1.27e-0349913GO:0005871
GeneOntologyCellularComponentcilium

NPHP1 SPTBN5 ULK3 EVC2 PRAMEF5 SLC24A4 MYO5A NMUR1 DLEC1 PRAMEF18 PRAMEF13

1.78e-038989111GO:0005929
DomainHISTONE_H3_1

H3C1 H3-3A H3-4

3.49e-067883PS00322
DomainH3

H3C1 H3-3A H3-4

5.56e-068883SM00428
DomainHISTONE_H3_2

H3C1 H3-3A H3-4

5.56e-068883PS00959
DomainHistone_H3/CENP-A

H3C1 H3-3A H3-4

5.56e-068883IPR000164
DomainPRAME_family

PRAMEF5 PRAMEF18 PRAMEF13

9.27e-0519883IPR026271
DomainKinesin_assoc

KIF13A KIF1C

3.25e-046882PF16183
DomainKinesin_assoc

KIF13A KIF1C

3.25e-046882IPR032405
DomainKinesin-like_fam

KIF15 KIF13A KIF1C

1.09e-0343883IPR027640
DomainKINESIN_MOTOR_1

KIF15 KIF13A KIF1C

1.16e-0344883PS00411
Domain-

KIF15 KIF13A KIF1C

1.16e-03448833.40.850.10
DomainKinesin_motor_dom

KIF15 KIF13A KIF1C

1.16e-0344883IPR001752
DomainKinesin

KIF15 KIF13A KIF1C

1.16e-0344883PF00225
DomainKINESIN_MOTOR_2

KIF15 KIF13A KIF1C

1.16e-0344883PS50067
DomainKISc

KIF15 KIF13A KIF1C

1.16e-0344883SM00129
DomainSpy1

SPDYE21 SPDYE5

1.17e-0311882PF11357
DomainSpeedy

SPDYE21 SPDYE5

1.17e-0311882IPR020984
DomainPH

SPTBN5 CDC42BPG RTKN2 ARHGAP23 FERMT1 OBSCN

2.01e-03278886SM00233
DomainPH_DOMAIN

SPTBN5 CDC42BPG RTKN2 ARHGAP23 FERMT1 OBSCN

2.05e-03279886PS50003
DomainPH_domain

SPTBN5 CDC42BPG RTKN2 ARHGAP23 FERMT1 OBSCN

2.09e-03280886IPR001849
DomainPkinase

ULK3 CDC42BPG GUCY2C OBSCN SNRK NEK9 NEK11

2.14e-03381887PF00069
DomainHistone

H3C1 H3-3A H3-4

2.34e-0356883PF00125
DomainHistone_H2A/H2B/H3

H3C1 H3-3A H3-4

2.34e-0356883IPR007125
DomainPH_dom-like

SPTBN5 CDC42BPG RTKN2 ARHGAP23 FERMT1 OBSCN WDFY4

3.97e-03426887IPR011993
DomainKinase-like_dom

ULK3 CDC42BPG GUCY2C OBSCN KNDC1 SNRK NEK9 NEK11

4.02e-03542888IPR011009
Domain-

LRWD1 NOD1 PRAMEF5 PRAMEF18 SHOC2 PRAMEF13

4.10e-033218863.80.10.10
Domain-

H3C1 H3-3A H3-4

4.23e-03698831.10.20.10
DomainL_dom-like

LRWD1 NOD1 PRAMEF5 PRAMEF18 SHOC2 PRAMEF13

4.55e-03328886IPR032675
DomainPH

SPTBN5 CDC42BPG RTKN2 FERMT1 OBSCN

4.56e-03229885PF00169
DomainUBQ-conjugating_AS

UBE2A UBE2B

6.14e-0325882IPR023313
DomainSer/Thr_kinase_AS

ULK3 CDC42BPG OBSCN SNRK NEK9 NEK11

6.81e-03357886IPR008271
DomainS_TKc

ULK3 CDC42BPG OBSCN SNRK NEK9 NEK11

6.99e-03359886SM00220
DomainHistone-fold

H3C1 H3-3A H3-4

7.08e-0383883IPR009072
DomainPROTEIN_KINASE_ST

ULK3 CDC42BPG OBSCN SNRK NEK9 NEK11

7.27e-03362886PS00108
PathwayKEGG_MEDICUS_VARIANT_IGH_MMSET_FUSION_TO_TRANSCRIPTIONAL_ACTIVATION

H3C1 H3-3A H3-4 H3C15

1.25e-0619624M47442
PathwayWP_EFFECT_OF_PROGERIN_ON_GENES_INVOLVED_IN_PROGERIA

MTA2 H3C1 H3-3A H3C15

2.01e-0537624M39756
PathwayREACTOME_REGULATION_OF_ENDOGENOUS_RETROELEMENTS_BY_KRAB_ZFP_PROTEINS

MTA2 H3C1 TRIM28 H3-3A H3C15

1.05e-04107625M48260
PathwayREACTOME_SENESCENCE_ASSOCIATED_SECRETORY_PHENOTYPE_SASP

VENTX H3C1 CDC26 H3-3A H3C15

1.25e-04111625M27187
PathwayWP_SENESCENCEASSOCIATED_SECRETORY_PHENOTYPE_SASP

VENTX H3C1 CDC26 H3-3A H3C15

1.31e-04112625M48334
PathwayREACTOME_CELLULAR_SENESCENCE

VENTX H3C1 CDC26 H3-3A H3-4 H3C15

2.21e-04197626M27188
PathwayREACTOME_CONDENSATION_OF_PROPHASE_CHROMOSOMES

H3C1 H3-3A H3-4 H3C15

2.94e-0473624M27166
PathwayREACTOME_ERCC6_CSB_AND_EHMT2_G9A_POSITIVELY_REGULATE_RRNA_EXPRESSION

MTA2 H3C1 H3-3A H3C15

3.26e-0475624M27343
PathwayKEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS

H3C1 H3-3A H3Y1 H3-4 H3C15

3.57e-04139625M4741
PathwayREACTOME_MITOTIC_PROPHASE

H3C1 H3-3A H3-4 H3C15 NEK9

3.94e-04142625M27660
PathwayREACTOME_REGULATION_OF_ENDOGENOUS_RETROELEMENTS

MTA2 H3C1 TRIM28 H3-3A H3C15

3.94e-04142625M48257
PathwayWP_FBXL10_ENHANCEMENT_OF_MAPERK_SIGNALING_IN_DIFFUSE_LARGE_BCELL_LYMPHOMA

H3C1 H3-3A H3C15

4.02e-0433623M39800
PathwayREACTOME_MEIOTIC_RECOMBINATION

H3C1 H3-3A H3-4 H3C15

6.00e-0488624M1011
PathwayREACTOME_REPRODUCTION

OVGP1 H3C1 H3-3A H3-4 H3C15

6.42e-04158625M26956
PathwayREACTOME_FORMATION_OF_THE_BETA_CATENIN_TCF_TRANSACTIVATING_COMPLEX

H3C1 H3-3A H3-4 H3C15

6.81e-0491624M27101
PathwayREACTOME_REGULATION_OF_ENDOGENOUS_RETROELEMENTS_BY_PIWI_INTERACTING_RNAS_PIRNAS

MTA2 H3C1 H3-3A H3C15

8.66e-0497624M48262
PathwayREACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION

H3C1 KIF15 H3-3A H3C15 KIF1C

8.93e-04170625M941
PathwayREACTOME_POSITIVE_EPIGENETIC_REGULATION_OF_RRNA_EXPRESSION

MTA2 H3C1 H3-3A H3C15

1.16e-03105624M27425
Pubmed

Ligand-dependent activation of the farnesoid X-receptor directs arginine methylation of histone H3 by CARM1.

H3C1 ABCB11 H3-3A H3C15

1.63e-081194415471871
Pubmed

SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins.

TRIM28 H3-4 H3C15

1.90e-07594311959841
Pubmed

PELP1 is a reader of histone H3 methylation that facilitates oestrogen receptor-alpha target gene activation by regulating lysine demethylase 1 specificity.

H3C1 H3-3A H3-4

6.64e-07794320448663
Pubmed

Silencing of unpaired chromatin and histone H2A ubiquitination in mammalian meiosis.

UBE2A UBE2B H3-3A

6.64e-07794315657431
Pubmed

Set9, a novel histone H3 methyltransferase that facilitates transcription by precluding histone tail modifications required for heterochromatin formation.

MTA2 H3C1 H3-4

1.06e-06894311850410
Pubmed

Human tNASP promotes in vitro nucleosome assembly with histone H3.3.

H3C1 H3-3A H3-4 H3C15

1.49e-063194425615412
Pubmed

Crystal structure of DPF3b in complex with an acetylated histone peptide.

H3C1 H3-3A H3-4

1.59e-06994327402533
Pubmed

A standardized nomenclature for mammalian histone genes.

H3C1 H3-3A H3Y1 H3-4 H3C15

1.80e-067494536180920
Pubmed

Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.

ZNF512B MTA2 NOP14 MDN1 SUGP2 TRIM28 POP1 ZNF638 RPL35 INO80 IMP3 TFCP2

3.09e-06847941235850772
Pubmed

Human PAD4 regulates histone arginine methylation levels via demethylimination.

H3-3A H3-4 H3C15

3.11e-061194315345777
Pubmed

ATRX proximal protein associations boast roles beyond histone deposition.

ZNF512B MTA2 NOP14 H3-3A IMP3

5.01e-069194534780483
Pubmed

HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.

ZNF512B MTA2 TRPC4AP VENTX H3C1 TRABD ZNF638 RPL35 H3-4 KIF13A WWC1

6.24e-06754941135906200
Pubmed

Expression patterns and post-translational modifications associated with mammalian histone H3 variants.

H3C1 H3-3A H3C15

6.81e-061494316267050
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

TGIF1 PRAMEF5 TMEM183A POP1 OBSCN ZNF638 INO80 ACCSL PRAMEF18 KIF13A PRAMEF13 WDFY4 CHST8

7.11e-061084941311544199
Pubmed

RAD6 promotes DNA repair and stem cell signaling in ovarian cancer and is a promising therapeutic target to prevent and treat acquired chemoresistance.

UBE2A UBE2B

7.23e-06294228806395
Pubmed

The ubiquitin-conjugating DNA repair enzyme HR6A is a maternal factor essential for early embryonic development in mice.

UBE2A UBE2B

7.23e-06294215169909
Pubmed

Loss of HR6B ubiquitin-conjugating activity results in damaged synaptonemal complex structure and increased crossing-over frequency during the male meiotic prophase.

UBE2A UBE2B

7.23e-06294212556476
Pubmed

Structural and functional conservation of two human homologs of the yeast DNA repair gene RAD6.

UBE2A UBE2B

7.23e-0629421717990
Pubmed

Localization of two human homologs, HHR6A and HHR6B, of the yeast DNA repair gene RAD6 to chromosomes Xq24-q25 and 5q23-q31.

UBE2A UBE2B

7.23e-0629421559696
Pubmed

A unique H3K4me2 profile marks tissue-specific gene regulation.

H3-3A H3-4

7.23e-06294220841431
Pubmed

The NMR structure of the class I human ubiquitin-conjugating enzyme 2b.

UBE2A UBE2B

7.23e-06294211885984
Pubmed

The host control of a clinical isolate strain of P. aeruginosa infection is independent of Nod-1 but depends on MyD88.

MYD88 NOD1

7.23e-06294229450586
Pubmed

Alternative Splicing of RAD6B and Not RAD6A is Selectively Increased in Melanoma: Identification and Functional Characterization.

UBE2A UBE2B

7.23e-06294231683936
Pubmed

Serine ADP-Ribosylation Depends on HPF1.

H3C1 H3-3A H3-4

8.50e-061594328190768
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

ZNF512B MTA2 SAMD1 SUGP2 ARHGAP23 EARS2 FAM120C TRIM28 TRABD TPRN H3-3A INO80 WWC1

9.69e-061116941331753913
Pubmed

Human Asf1 regulates the flow of S phase histones during replicational stress.

H3C1 H3-3A H3-4

1.04e-051694315664198
Pubmed

Differential expression of PRAMEL1, a cancer/testis antigen, during spermatogenesis in the mouse.

PRAMEF5 PRAMEF18 PRAMEF13

1.26e-051794323565261
Pubmed

Mouse Pramel1 regulates spermatogonial development by inhibiting retinoic acid signaling during spermatogenesis.

PRAMEF5 PRAMEF18 PRAMEF13

1.26e-051794337781892
Pubmed

The promoter of the oocyte-specific gene, Oog1, functions in both male and female meiotic germ cells in transgenic mice.

PRAMEF5 PRAMEF18 PRAMEF13

1.51e-051894323894331
Pubmed

RAD6-Mediated transcription-coupled H2B ubiquitylation directly stimulates H3K4 methylation in human cells.

UBE2A UBE2B H3C1

1.51e-051894319410543
Pubmed

Oogenesin is a novel mouse protein expressed in oocytes and early cleavage-stage embryos.

PRAMEF5 PRAMEF18 PRAMEF13

1.51e-051894312890732
Pubmed

Oocyte-specific gene Oog1 suppresses the expression of spermatogenesis-specific genes in oocytes.

PRAMEF5 PRAMEF18 PRAMEF13

1.51e-051894329731491
Pubmed

Identification of a new expanding family of genes characterized by atypical LRR domains. Localization of a cluster preferentially expressed in oocyte.

PRAMEF5 PRAMEF18 PRAMEF13

1.51e-051894314675769
Pubmed

Regulation of transcription by the heterogeneous nuclear ribonucleoprotein E1B-AP5 is mediated by complex formation with the novel bromodomain-containing protein BRD7.

H3C1 H3-4 H3C15

1.51e-051894312489984
Pubmed

Pramel15 facilitates zygotic nuclear DNMT1 degradation and DNA demethylation.

PRAMEF5 PRAMEF18 PRAMEF13

1.51e-051894339181896
Pubmed

Pramel7 mediates ground-state pluripotency through proteasomal-epigenetic combined pathways.

PRAMEF5 PRAMEF18 PRAMEF13

1.80e-051994328604677
Pubmed

ZAR1 and ZAR2 are required for oocyte meiotic maturation by regulating the maternal transcriptome and mRNA translational activation.

PRAMEF5 RPL35 PRAMEF18 PRAMEF13

1.90e-055894431598710
Pubmed

Np95 is a histone-binding protein endowed with ubiquitin ligase activity.

H3C1 H3-3A H3-4

2.11e-052094314993289
Pubmed

Preferentially Expressed Antigen in Melanoma (PRAME) and the PRAME Family of Leucine-Rich Repeat Proteins.

PRAMEF5 PRAMEF18 PRAMEF13

2.11e-052094326694250
Pubmed

Oog1, an oocyte-specific protein, interacts with Ras and Ras-signaling proteins during early embryogenesis.

PRAMEF5 PRAMEF18 PRAMEF13

2.11e-052094316580637
Pubmed

Pramel7 mediates LIF/STAT3-dependent self-renewal in embryonic stem cells.

PRAMEF5 PRAMEF18 PRAMEF13

2.11e-052094321425410
Pubmed

Helicobacter pylori cag pathogenicity island (cagPAI) involved in bacterial internalization and IL-8 induced responses via NOD1- and MyD88-dependent mechanisms in human biliary epithelial cells.

MYD88 NOD1

2.16e-05394224143223
Pubmed

RNF168 forms a functional complex with RAD6 during the DNA damage response.

UBE2A UBE2B

2.16e-05394223525009
Pubmed

The human RAD18 gene product interacts with HHR6A and HHR6B.

UBE2A UBE2B

2.16e-05394210908344
Pubmed

Relevance of the myeloid differentiation factor 88 (MyD88) on RANKL, OPG, and nod expressions induced by TLR and IL-1R signaling in bone marrow stromal cells.

MYD88 NOD1

2.16e-05394225125146
Pubmed

Molecular recognition of histone H3 by the WD40 protein WDR5.

H3C1 H3C15

2.16e-05394216829960
Pubmed

Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex.

H3C1 H3C15

2.16e-05394216829959
Pubmed

Activation of host mitogen-activated protein kinases by secreted Legionella pneumophila effectors that inhibit host protein translation.

MYD88 NOD1

2.16e-05394222851749
Pubmed

Enhanced genomic instability and defective postreplication repair in RAD18 knockout mouse embryonic stem cells.

UBE2A UBE2B

2.16e-05394212509447
Pubmed

UBE2A and UBE2B are recruited by an atypical E3 ligase module in UBR4.

UBE2A UBE2B

2.16e-05394238182926
Pubmed

Dysfunction of human Rad18 results in defective postreplication repair and hypersensitivity to multiple mutagens.

UBE2A UBE2B

2.16e-05394210884424
Pubmed

Regulation of bone mass by the gut microbiota is dependent on NOD1 and NOD2 signaling.

MYD88 NOD1

2.16e-05394228576260
Pubmed

Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins.

H3C1 H3-3A H3C15

2.45e-052194311242053
Pubmed

Sertoli cell-only phenotype and scRNA-seq define PRAMEF12 as a factor essential for spermatogenesis in mice.

PRAMEF5 PRAMEF18 PRAMEF13

2.84e-052294331729367
Pubmed

Mouse screen reveals multiple new genes underlying mouse and human hearing loss.

MYD88 TRPC4AP PRAMEF5 MDN1 MYO5A USHBP1 EARS2 LSM11 KLK5 PRAMEF18 PRAMEF13 NEK9 RNF157

2.97e-051242941330973865
Pubmed

Oogenesis specific genes (Nobox, Oct4, Bmp15, Gdf9, Oogenesin1 and Oogenesin2) are differentially expressed during natural and gonadotropin-induced mouse follicular development.

PRAMEF5 PRAMEF18 PRAMEF13

3.26e-052394319480014
Pubmed

CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.

ZNF512B MTA2 NOP14 MDN1 SUGP2 TRIM28 ZNF638 RPL35 H3C15

3.93e-0560594928977666
Pubmed

Identification and classification of 16 new kinesin superfamily (KIF) proteins in mouse genome.

KIF15 KIF13A KIF1C

4.21e-05259439275178
Pubmed

MAGE-B4, a binding partner of PRAMEF12, is dispensable for spermatogenesis and male fertility in mice.

PRAMEF5 PRAMEF18 PRAMEF13

4.21e-052594337451217
Pubmed

Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei.

PRAMEF5 PRAMEF18 PRAMEF13

4.21e-052594312620990
Pubmed

Viral reprogramming of the Daxx histone H3.3 chaperone during early Epstein-Barr virus infection.

H3C1 H3-3A

4.32e-05494225275136
Pubmed

Homeostatic control of memory cell progenitors in the natural killer cell lineage.

MYD88 NOD1

4.32e-05494225578733
Pubmed

Rad6 overexpression induces multinucleation, centrosome amplification, abnormal mitosis, aneuploidy, and transformation.

UBE2A UBE2B

4.32e-05494211929833
Pubmed

Intestinal lysozyme liberates Nod1 ligands from microbes to direct insulin trafficking in pancreatic beta cells.

MYD88 NOD1

4.32e-05494231201384
Pubmed

Identification and characterization of propionylation at histone H3 lysine 23 in mammalian cells.

H3C1 H3C15

4.32e-05494219801601
Pubmed

Hemi-methylated DNA regulates DNA methylation inheritance through allosteric activation of H3 ubiquitylation by UHRF1.

H3C1 H3-4

4.32e-05494227595565
Pubmed

Histone methyltransferase Suv39h1 represses MyoD-stimulated myogenic differentiation.

H3C1 H3-4

4.32e-05494216858404
Pubmed

Nod1 and Nod2 induce CCL5/RANTES through the NF-kappaB pathway.

MYD88 NOD1

4.32e-05494217705131
Pubmed

RICK/RIP2 mediates innate immune responses induced through Nod1 and Nod2 but not TLRs.

MYD88 NOD1

4.32e-05494217277144
Pubmed

Human SFMBT is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3.

H3C1 H3-4

4.32e-05494217599839
Pubmed

A conserved RAD6-MDM2 ubiquitin ligase machinery targets histone chaperone ASF1A in tumorigenesis.

UBE2A UBE2B

4.32e-05494226336826
Pubmed

JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin.

H3C1 H3-4

4.32e-05494219783980
Pubmed

A novel enhancer of the Apaf1 apoptosome involved in cytochrome c-dependent caspase activation and apoptosis.

NOD1 APAF1

4.32e-05494211113115
Pubmed

Requirement of Rsk-2 for epidermal growth factor-activated phosphorylation of histone H3.

H3C1 H3-4

4.32e-05494210436156
Pubmed

Nod2-mediated recognition of the microbiota is critical for mucosal adjuvant activity of cholera toxin.

MYD88 NOD1

4.32e-05494227064448
Pubmed

RAD6 promotes homologous recombination repair by activating the autophagy-mediated degradation of heterochromatin protein HP1.

UBE2A UBE2B

4.32e-05494225384975
Pubmed

IFI16 Partners with KAP1 to Maintain Epstein-Barr Virus Latency.

H3C1 TRIM28

4.32e-05494235969079
Pubmed

Phosphorylation of KRAB-associated protein 1 (KAP1) at Tyr-449, Tyr-458, and Tyr-517 by nuclear tyrosine kinases inhibits the association of KAP1 and heterochromatin protein 1α (HP1α) with heterochromatin.

TRIM28 H3-4

4.32e-05494223645696
Pubmed

Purification and functional characterization of a histone H3-lysine 4-specific methyltransferase.

H3C1 H3-4

4.32e-05494211779497
Pubmed

RAD6 regulates the dosage of p53 by a combination of transcriptional and posttranscriptional mechanisms.

UBE2A UBE2B

4.32e-05494222083959
Pubmed

Mutations of Rad6 E2 ubiquitin-conjugating enzymes at alanine-126 in helix-3 affect ubiquitination activity and decrease enzyme stability.

UBE2A UBE2B

4.32e-05494236162503
Pubmed

ZNF198 protein, involved in rearrangement in myeloproliferative disease, forms complexes with the DNA repair-associated HHR6A/6B and RAD18 proteins.

UBE2A UBE2B

4.32e-05494212776193
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

ZNF512B MTA2 SAMD1 LRWD1 MDN1 H3C1 TRIM28 CDC26 POP1 ZNF638 RPL35 INO80 TFCP2

4.53e-051294941330804502
Pubmed

Expression profiling in transgenic FVB/N embryonic stem cells overexpressing STAT3.

PRAMEF5 PRAMEF18 PRAMEF13

4.75e-052694318500982
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

SAMD1 LRWD1 NOP14 MDN1 H3C1 MYO5A FAM120C POP1 LSM11 INO80 IMP3 H3C15 DGAT1 EPN2

4.89e-051497941431527615
Pubmed

Molecular Characterization of the Oncogene BTF3 and Its Targets in Colorectal Cancer.

MTA2 H3C1 MYO5A TRIM28 H3-3A RPL35 H3-4 H3C15 TFCP2

5.12e-0562694933644029
Pubmed

The ubiquitin-specific protease USP36 SUMOylates EXOSC10 and promotes the nucleolar RNA exosome function in rRNA processing.

MTA2 NOP14 H3C1 SUGP2 TRIM28 POP1 ZNF638 IMP3

5.12e-0548394836912080
Pubmed

Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination.

MTA2 SAMD1 H3C1 TRIM28

5.25e-057594425593309
Pubmed

Differences in gene expression between mouse and human for dynamically regulated genes in early embryo.

PRAMEF5 PRAMEF18 PRAMEF13

5.96e-052894325089626
Pubmed

Transcriptome analysis of mouse stem cells and early embryos.

ABHD4 PRAMEF5 MDN1 POP1 PRAMEF18 PRAMEF13 MOCS1

5.99e-0536394714691545
Pubmed

SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18.

MTA2 TRIM28 POP1 ZNF638 RPL35 H3C15

6.38e-0525194631076518
Pubmed

Structures of human nucleosomes containing major histone H3 variants.

H3C1 H3-3A H3C15

6.64e-052994321636898
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

MTA2 LRWD1 NOP14 MDN1 SUGP2 MYO5A ARHGAP23 TRIM28 FERMT1 POP1 ZNF638 RPL35 NEK9

7.12e-051353941329467282
Pubmed

Histone H4K20/H3K9 demethylase PHF8 regulates zebrafish brain and craniofacial development.

L3MBTL1 H3C1

7.19e-05594220622853
Pubmed

Modifications of human histone H3 variants during mitosis.

H3-3A H3C15

7.19e-05594216185088
Pubmed

MyD88 and TNF receptor-associated factor 6 are critical signal transducers in Helicobacter pylori-infected human epithelial cells.

MYD88 NOD1

7.19e-05594216517750
Pubmed

Rad18 guides poleta to replication stalling sites through physical interaction and PCNA monoubiquitination.

UBE2A UBE2B

7.19e-05594215359278
Pubmed

Recognition of gut microbiota by NOD2 is essential for the homeostasis of intestinal intraepithelial lymphocytes.

MYD88 NOD1

7.19e-05594224062413
Pubmed

Human spleen histone H3. Isolation and amino acid sequence.

H3-3A H3C15

7.19e-0559427309716
Pubmed

Recognition of forked and single-stranded DNA structures by human RAD18 complexed with RAD6B protein triggers its recruitment to stalled replication forks.

UBE2A UBE2B

7.19e-05594218363965
InteractionMEN1 interactions

ZNF512B MTA2 SAMD1 NOP14 MDN1 H3C1 SUGP2 EARS2 FAM120C TRIM28 POP1 ZNF638 H3-3A RPL35 INO80 H3-4 IMP3 TFCP2

2.25e-0710298518int:MEN1
InteractionH2AC13 interactions

H3C1 H3-3A RPL35 H3-4 H3C15

1.62e-0575855int:H2AC13
InteractionGTF3C4 interactions

H3C1 TRIM28 ZNF638 H3-3A SNRK H3-4 H3C15

1.86e-05195857int:GTF3C4
InteractionH3-4 interactions

MTA2 LRWD1 H3C1 TRIM28 CDC26 POP1 APAF1 H3-3A H3-4 H3C15

1.88e-054488510int:H3-4
InteractionCBX5 interactions

ULK3 UBE2A UBE2B L3MBTL1 H3C1 TRIM28 H3-3A H3-4 H3C15

1.91e-05356859int:CBX5
InteractionH1-4 interactions

ZNF512B NOP14 L3MBTL1 H3C1 POP1 ZNF638 H3-3A H3-4 IMP3 H3C15 NEK9 FMNL1

1.92e-056568512int:H1-4
InteractionRAD18 interactions

MTA2 UBE2A UBE2B H3C1 TRIM28 POP1 ZNF638 H3-3A RPL35 H3C15

2.23e-054578510int:RAD18
InteractionDOT1L interactions

ZNF512B MTA2 NOP14 MDN1 TRIM28 POP1 ZNF638 H3-3A RPL35 INO80 H3-4 IMP3 TFCP2

3.18e-058078513int:DOT1L
InteractionMPHOSPH8 interactions

LRWD1 H3C1 ZNF638 H3-3A IMP3

4.60e-0593855int:MPHOSPH8
InteractionH2AC4 interactions

LRWD1 MDN1 H3C1 POP1 ZNF638 H3-3A INO80 H3-4 H3C15 TFCP2

5.28e-055068510int:H2AC4
InteractionEHMT2 interactions

ZNF512B LRWD1 L3MBTL1 H3C1 TRIM28 H3-3A H3-4 H3C15

5.52e-05315858int:EHMT2
InteractionSHPRH interactions

ZNF512B MTA2 UBE2A H3C1 H3-3A

5.63e-0597855int:SHPRH
InteractionH2AC20 interactions

ULK3 UBE2A UBE2B H3C1 H3-3A INO80 H3-4 H3C15

6.17e-05320858int:H2AC20
InteractionCHAF1A interactions

ZNF512B MTA2 MDN1 H3C1 TRIM28 H3-3A H3-4 TIGD6

6.44e-05322858int:CHAF1A
InteractionH2BC5 interactions

UBE2A NOP14 H3C1 H3-3A RPL35 H3-4 H3C15 EPN2

7.81e-05331858int:H2BC5
InteractionCBX3 interactions

ZNF512B ULK3 LRWD1 NOP14 L3MBTL1 H3C1 TRIM28 H3-3A SNRK H3-4 H3C15

8.35e-056468511int:CBX3
InteractionRPS27A interactions

ZNF512B NPHP1 H3C1 TRIM28 H3-3A RPL35 H3-4 WDFY4 H3C15 EPN2

8.52e-055368510int:RPS27A
InteractionUBA52 interactions

UBE2A UBE2B H3C1 TRIM28 H3-3A RPL35 H3-4 H3C15 EPN2

9.36e-05437859int:UBA52
InteractionH3C1 interactions

ZNF512B MTA2 LRWD1 UBE2A H3C1 TRIM28 POP1 ZNF638 H3-3A RPL35 H3-4 H3C15 WWC1

9.77e-059018513int:H3C1
InteractionKIFBP interactions

TRPC4AP KIF15 TRIM28 ZNF638 KIF13A KIF1C

1.14e-04180856int:KIFBP
InteractionHMGXB4 interactions

ZNF512B MTA2 H3C1 H3-3A H3-4

1.16e-04113855int:HMGXB4
InteractionYY1 interactions

ZNF512B MTA2 H3C1 POP1 ZNF638 H3-3A INO80 H3-4 TFCP2

1.25e-04454859int:YY1
InteractionLRWD1 interactions

LRWD1 H3C1 TRIM28 H3-3A H3-4

1.43e-04118855int:LRWD1
InteractionEHMT1 interactions

LRWD1 L3MBTL1 H3C1 TRIM28 H3-3A H3-4

1.44e-04188856int:EHMT1
InteractionSMARCA1 interactions

ZNF512B MTA2 H3C1 TRIM28 H3-3A EPN2

1.44e-04188856int:SMARCA1
InteractionZMYM2 interactions

ZNF512B MTA2 SAMD1 UBE2A UBE2B H3C1 H3-3A

1.49e-04271857int:ZMYM2
InteractionZNF780A interactions

H3C1 TRIM28 H3-3A

1.56e-0425853int:ZNF780A
InteractionZMYND8 interactions

ZNF512B MTA2 SAMD1 H3C1 TRIM28 WWC1

1.57e-04191856int:ZMYND8
InteractionZNF257 interactions

H3C1 TRIM28

1.74e-045852int:ZNF257
InteractionCBX2 interactions

MDN1 L3MBTL1 H3C1 H3-3A H3-4

1.94e-04126855int:CBX2
InteractionSIN3A interactions

ZNF512B MTA2 TGIF1 H3C1 TRIM28 H3-3A H3-4 TFCP2

2.02e-04380858int:SIN3A
InteractionHMGB1 interactions

TGIF1 NOP14 H3C1 ARHGAP23 TRIM28 H3-3A RPL35 KIF13A H3C15

2.08e-04486859int:HMGB1
InteractionLOC102724334 interactions

H3C1 H3-3A H3-4 SHOC2 H3C15

2.58e-04134855int:LOC102724334
InteractionKDM5A interactions

H3C1 H3-3A H3-4 H3C15

2.71e-0474854int:KDM5A
InteractionMYO6 interactions

H3C1 FAM120C TRIM28 ZNF638 WDFY4 H3C15 TFCP2 EPN2

2.76e-04398858int:MYO6
InteractionH3-3A interactions

ZNF512B MTA2 SAMD1 LRWD1 NOP14 H3C1 TRIM28 H3-3A INO80 H3-4 H3C15

3.03e-047498511int:H3-3A
InteractionHAT1 interactions

ZNF512B MTA2 H3C1 TRIM28 H3-3A H3-4

3.13e-04217856int:HAT1
InteractionFOXQ1 interactions

LRWD1 NOP14 SUGP2 POP1 TFCP2

3.27e-04141855int:FOXQ1
InteractionSETD7 interactions

L3MBTL1 H3C1 H3-3A H3-4

3.31e-0478854int:SETD7
InteractionSET interactions

MDN1 H3C1 TRIM28 H3-3A RPL35 H3-4 H3C15

3.44e-04311857int:SET
InteractionKMT5A interactions

L3MBTL1 H3C1 H3-3A RPL35

3.65e-0480854int:KMT5A
Cytoband15q21

SPTBN5 MYO5A

2.25e-041194215q21
Cytoband1p36.21

PRAMEF5 PRAMEF18 PRAMEF13

3.02e-04639431p36.21
GeneFamilyPRAME family

PRAMEF5 PRAMEF18 PRAMEF13

6.36e-0524593686
GeneFamilyKinesins|Pleckstrin homology domain containing

KIF15 KIF13A KIF1C

4.53e-0446593622
GeneFamilyHistones

H3C1 H3-3A H3-4 H3C15

5.58e-04116594864
GeneFamilyWD repeat domain containing|Caspase recruitment domain containing|Apoptosome

NOD1 APAF1

4.29e-0330592959
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

CDC42BPG RTKN2 ARHGAP23 FERMT1

4.57e-03206594682
GeneFamilyUbiquitin conjugating enzymes E2

UBE2A UBE2B

7.91e-0341592102
DiseaseGLIOMA SUSCEPTIBILITY 1

H3C1 H3-3A

1.28e-046872C2750850
DiseaseDiarrhea

GUCY2C DGAT1

4.65e-0411872C0011991
DiseasePneumoconiosis

OVGP1 H3-4

7.64e-0414872C0032273
DiseaseBagassosis

OVGP1 H3-4

7.64e-0414872C0004681
Diseasesyndromic intellectual disability (implicated_via_orthology)

UBE2A UBE2B

1.00e-0316872DOID:0050888 (implicated_via_orthology)
DiseaseQRS duration, response to sulfonylurea

MDN1 ZNF638

2.09e-0323872EFO_0005055, EFO_0007922

Protein segments in the cluster

PeptideGeneStartEntry
RLQERRSLMKILSEP

USHBP1

431

Q8N6Y0
IFADELPRLKLAMRR

ACCSL

531

Q4AC99
RLRILMLRKHPRSLL

APAF1

226

O14727
MLRLRLPNLKMVRLR

FERMT1

96

Q9BQL6
ARRPMLERIHLIRKD

ABHD4

266

Q8TB40
RALIRNPKILLLDMA

ABCB11

571

O95342
MLRRKPTRLELKLDD

CDC26

1

Q8NHZ8
PRIRKRFLLRRILEM

DGAT1

271

O75907
DRRLLGKRKRRELNM

CCDC121

161

Q6ZUS5
MALRGTLRPLKVRRR

SLC24A4

1

Q8NFF2
LTRLARRMCRDLLQP

MTA2

461

O94776
DRADRLNFMLLPRLV

GUCY2C

791

P25092
ETLPRARRLTKEMLL

INO80

331

Q9ULG1
LRDRLPEMLRDKASL

CDC42BPG

456

Q6DT37
ARLLMQRGRPKSDRL

LRWD1

6

Q9UFC0
ELELAELKTRRRPML

EXO5

191

Q9H790
SAMRRLKRRLVPSER

OR4D11

296

Q8NGI4
GELLRRLPKLRKRMR

MDN1

4051

Q9NU22
DPERIQRLRRLMVAK

LSM11

106

P83369
RLRLLEPVKRAQEMD

KIF15

526

Q9NS87
LRLRRERLLLMQEAK

NMUR1

256

Q9HB89
ELLDRPLLRKRRREM

NEK9

301

Q8TD19
RLLLRMLEKRQMDRA

WWC1

1041

Q8IX03
RLRRGDDLRLQMALE

EPN2

296

O95208
MPKDIQLARRIRGER

H3-3A

121

P84243
LNLMREEGIKLARRR

LIPT1

86

Q9Y234
TLPRARIMQRKRGLE

ATP9B

71

O43861
RREKLMLARRGITLQ

HMGN2P46

126

Q86SG4
MPRDMQLARRLRREG

H3Y1

121

P0DPK2
PDFLRLLRLIRDMEA

PNMA6F

411

A0A0J9YX94
MKLEAVDRRNPALIR

L3MBTL1

521

Q9Y468
ELMRILREVREPKRI

PRAMEF18

436

Q5VWM3
PRERMRLRKLQAADE

NEK11

341

Q8NG66
ARRMFPERALQDRLL

NOD1

361

Q9Y239
LRDRMLRMERVIPLA

KIF1C

861

O43896
QMDRSLALPKIRARV

EVC2

861

Q86UK5
PLAALNMRVRRRLSL

MYD88

21

Q99836
MPKDIQLARRIRGER

H3-4

121

Q16695
SNDLMLIKLNRRIRP

KLK5

151

Q9Y337
MPKDIQLARRIRGER

H3C1

121

P68431
LRKLEAERLRRMLGK

NOP14

286

P78316
MAARPLSRMLRRLLR

MOCS1

1

Q9NZB8
MPDDNKRIRRVRLLV

PTER

271

Q96BW5
EALARKRRMSREPTL

OBSCN

4741

Q5VST9
RRAMSHNVKRLPRRL

POP1

141

Q99575
LRVLKLVRFMPALRR

CACNA1I

736

Q9P0X4
TQRKMERLAMRRRLP

FAM120C

671

Q9NX05
RRPQMDLISELKRRQ

FMNL1

1036

O95466
FCRRRLPTVLLKLRM

IMP3

106

Q9NV31
LPRSLRMRDKRADFV

KLHDC8B

261

Q8IXV7
LPRRLKTLLLDMARR

KNDC1

551

Q76NI1
RSRRCMRKDLPDLLE

CCDC174

171

Q6PII3
HLGNEMLRLKRPILR

CCDC168

5321

Q8NDH2
MLRLKRPILRRISHI

CCDC168

5326

Q8NDH2
RLERRLRMLDNPVEK

FAM240B

56

A0A1B0GVZ2
RVPQRELDRLLLARM

DLEC1

306

Q9Y238
KARPDLERICRMVRR

SAMD1

46

Q6SPF0
MLARRQRDPLQALRR

NPHP1

1

O15259
HMLLTQKDRPRRRKL

PRAMEF13

86

Q5VWM6
AFRKEALLTMRPRLL

OVGP1

166

Q12889
SAMRRLKRRLVPSDR

OR4D10

296

Q8NGI6
RVRPMNRRELELNTK

KIF13A

11

Q9H1H9
MAAPRKLLPARRNRL

RTKN2

556

Q8IZC4
EVDRMLALQPRLRLR

SYT8

381

Q8NBV8
RMKRAERRILLLIDN

TIGD6

271

Q17RP2
LDLRPKKTRAMRRRL

RPL35

81

P42766
RLPFRALLQIRAMRK

RNF157

316

Q96PX1
LMLARRKERLPLYLR

TRPC4AP

696

Q8TEL6
RKERLPLYLRLLQRM

TRPC4AP

701

Q8TEL6
MPKDIQLARRIRGER

H3C15

121

Q71DI3
RLPLRLLCESMKRQI

SGSM2

481

O43147
LRMLDLRHNKLREIP

SHOC2

171

Q9UQ13
ITRMLQRDPKRRASL

SNRK

246

Q9NRH2
MAALLRRLLQRERPS

EARS2

1

Q5JPH6
RDRLPILLQRRMRVK

SPTBN5

2121

Q9NRC6
RLRQRRRRLLIKKMP

CHST8

106

Q9H2A9
INARRRLLPDMLRKD

TGIF1

216

Q15583
MRRLPRALLLQLRLA

POGLUT3

1

Q7Z4H8
LRLRPESMEKLRCLR

TMEM183A

186

Q8IXX5
RLFNALKGRMVRPRL

TFCP2

376

Q12800
LLEMKLKRRRQRPNL

TRABD

46

Q9H4I3
MLRQAARRLELPRAS

TRABD

266

Q9H4I3
IPLLRKRRFQLGRSM

SPDYE21

306

A0A494C086
IPLLRKRRFQLGRSM

SPDYE5

306

A6NIY4
IPLLRKRRFQLGRSM

SPDYE5

331

A6NIY4
RERMRTLRKLIRDLP

ARHGAP23

1011

Q9P227
NLRLPRRKMSFDIID

SUGP2

306

Q8IX01
FPQIRAELMKRVRDL

PRAMEF5

431

Q5TYX0
RMRKRIKRLSPLEAL

WDFY4

2296

Q6ZS81
RRRLMRDFKRLQEDP

UBE2A

6

P49459
RERLRKVLKQMGRLR

ZNF512B

581

Q96KM6
LRENPFMLLEAERRR

TPRN

56

Q4KMQ1
RRRLMRDFKRLQEDP

UBE2B

6

P63146
PLILRDIRMRKMGRR

ZNF638

171

Q14966
LSPLERKRLAREMQL

VENTX

116

O95231
KRRRRRRLMELAEPK

THEG

121

Q9P2T0
LMRKVPRVSLERLDL

TRIM28

481

Q13263
SARDLLREMARDKPR

ULK3

361

Q6PHR2
LREMARDKPRLLAAL

ULK3

366

Q6PHR2
IRTIQMRLRDRKDSP

MYO5A

1801

Q9Y4I1