Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	DDT	BAZ2A BAZ2B	5.86e-05	4	59	2	PF02791
Domain	DDT	BAZ2A BAZ2B	9.75e-05	5	59	2	SM00571
Domain	WSD	BAZ2A BAZ2B	9.75e-05	5	59	2	PF15613
Domain	DDT_dom	BAZ2A BAZ2B	9.75e-05	5	59	2	IPR018501
Domain	WHIM2_dom	BAZ2A BAZ2B	9.75e-05	5	59	2	IPR028941
Domain	BRK	CHD8 CHD6	1.46e-04	6	59	2	SM00592
Domain	DDT	BAZ2A BAZ2B	1.46e-04	6	59	2	PS50827
Domain	BRK_domain	CHD8 CHD6	1.46e-04	6	59	2	IPR006576
Domain	BRK	CHD8 CHD6	1.46e-04	6	59	2	PF07533
Domain	-	BAZ2A BAZ2B	2.71e-04	8	59	2	3.30.890.10
Domain	Methyl_CpG_DNA-bd	BAZ2A BAZ2B	5.30e-04	11	59	2	IPR001739
Domain	MBD	BAZ2A BAZ2B	5.30e-04	11	59	2	PF01429
Domain	DNA-bd_dom	BAZ2A BAZ2B	5.30e-04	11	59	2	IPR016177
Domain	MBD	BAZ2A BAZ2B	5.30e-04	11	59	2	SM00391
Domain	MBD	BAZ2A BAZ2B	5.30e-04	11	59	2	PS50982
Domain	RCC1	HERC2 HERC1	1.80e-03	20	59	2	PF00415
Domain	MAGE_N	MAGEA1 MAGEB1	1.80e-03	20	59	2	SM01392
Domain	RCC1_1	HERC2 HERC1	1.98e-03	21	59	2	PS00625
Domain	RCC1_2	HERC2 HERC1	1.98e-03	21	59	2	PS00626
Domain	RCC1_3	HERC2 HERC1	1.98e-03	21	59	2	PS50012
Domain	Reg_chr_condens	HERC2 HERC1	2.18e-03	22	59	2	IPR000408
Domain	MAGE_N	MAGEA1 MAGEB1	2.18e-03	22	59	2	PF12440
Domain	-	HERC2 HERC1	2.18e-03	22	59	2	2.130.10.30
Domain	MAGE_N	MAGEA1 MAGEB1	2.18e-03	22	59	2	IPR021072
Domain	RCC1/BLIP-II	HERC2 HERC1	2.38e-03	23	59	2	IPR009091
Domain	Chromo_domain	CHD8 CHD6	2.59e-03	24	59	2	IPR023780
Domain	UBQ-conjugating_AS	UBE2D2 UBE2D3	2.81e-03	25	59	2	IPR023313
Domain	Bromodomain_CS	BAZ2A BAZ2B	3.04e-03	26	59	2	IPR018359
Domain	Chromo	CHD8 CHD6	3.04e-03	26	59	2	PF00385
Domain	HECT	HERC2 HERC1	3.27e-03	27	59	2	PF00632
Domain	HECTc	HERC2 HERC1	3.27e-03	27	59	2	SM00119
Domain	HECT_dom	HERC2 HERC1	3.27e-03	27	59	2	IPR000569
Domain	HECT	HERC2 HERC1	3.27e-03	27	59	2	PS50237
Domain	CHROMO_1	CHD8 CHD6	3.52e-03	28	59	2	PS00598
Domain	CHROMO_2	CHD8 CHD6	3.52e-03	28	59	2	PS50013
Domain	UBA	USP5 MARK2	4.03e-03	30	59	2	SM00165
Domain	SNF2_N	CHD8 CHD6	4.58e-03	32	59	2	IPR000330
Domain	Chromodomain-like	CHD8 CHD6	4.58e-03	32	59	2	IPR016197
Domain	SNF2_N	CHD8 CHD6	4.58e-03	32	59	2	PF00176
Domain	Helicase_C	CHD8 CHD6 DDX4	4.71e-03	107	59	3	PF00271
Domain	HELICc	CHD8 CHD6 DDX4	4.71e-03	107	59	3	SM00490
Domain	Helicase_C	CHD8 CHD6 DDX4	4.83e-03	108	59	3	IPR001650
Domain	Chromo/shadow_dom	CHD8 CHD6	4.86e-03	33	59	2	IPR000953
Domain	CHROMO	CHD8 CHD6	4.86e-03	33	59	2	SM00298
Domain	HELICASE_CTER	CHD8 CHD6 DDX4	4.96e-03	109	59	3	PS51194
Domain	HELICASE_ATP_BIND_1	CHD8 CHD6 DDX4	4.96e-03	109	59	3	PS51192
Domain	DEXDc	CHD8 CHD6 DDX4	4.96e-03	109	59	3	SM00487
Domain	Helicase_ATP-bd	CHD8 CHD6 DDX4	5.09e-03	110	59	3	IPR014001
Domain	MAGE	MAGEA1 MAGEB1	5.16e-03	34	59	2	SM01373
Domain	DNA/RNA_helicase_DEAH_CS	CHD8 CHD6	5.46e-03	35	59	2	IPR002464
Domain	UBA	USP5 MARK2	5.77e-03	36	59	2	PF00627
Domain	MAGE	MAGEA1 MAGEB1	5.77e-03	36	59	2	PS50838
Domain	MAGE	MAGEA1 MAGEB1	5.77e-03	36	59	2	PF01454
Domain	MHD_dom	MAGEA1 MAGEB1	5.77e-03	36	59	2	IPR002190
Domain	BROMODOMAIN_1	BAZ2A BAZ2B	6.09e-03	37	59	2	PS00633
Pubmed	Identification of substrates of SMURF1 ubiquitin ligase activity utilizing protein microarrays.	USP5 UBE2D2 UBE2D3 MAP4K5 PRKCI MARK2	9.24e-09	87	60	6	20804422
Pubmed	System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.	UBE2D2 UBE2D3 HERC2 HERC1	1.16e-07	26	60	4	26949039
Pubmed	Inflammasome activation and metabolic remodelling in p16-positive aging cells aggravates high-fat diet-induced lung fibrosis by inhibiting NEDD4L-mediated K48-polyubiquitin-dependent degradation of SGK1.	UBE2D2 UBE2D3 GAA	5.81e-07	10	60	3	37345264
Pubmed	Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity.	UBR2 UBE2D2 UBE2D3 HERC2 HERC1	6.63e-07	95	60	5	29643511
Pubmed	Filamin-A is required to mediate SST2 effects in pancreatic neuroendocrine tumours.	FLNA SSTR2	2.93e-06	2	60	2	26733502
Pubmed	Filamin A (FLNA) plays an essential role in somatostatin receptor 2 (SST2) signaling and stabilization after agonist stimulation in human and rat somatotroph tumor cells.	FLNA SSTR2	2.93e-06	2	60	2	24828612
Pubmed	Autoregulation of the 26S proteasome by in situ ubiquitination.	UBE2D2 UBE2D3 HERC2	4.64e-06	19	60	3	24743594
Pubmed	Filamin A interacts with the coactivator MKL1 to promote the activity of the transcription factor SRF and cell migration.	FLNA MRTFA	8.77e-06	3	60	2	26554816
Pubmed	Identification of a family of closely related human ubiquitin conjugating enzymes.	UBE2D2 UBE2D3	8.77e-06	3	60	2	8530467
Pubmed	Structural basis of molecular recognition of helical histone H3 tail by PHD finger domains.	BAZ2A BAZ2B	8.77e-06	3	60	2	28341809
Pubmed	Structural and functional characterization of hMEX-3C Ring finger domain as an E3 ubiquitin ligase.	UBE2D2 UBE2D3	8.77e-06	3	60	2	30095198
Pubmed	Chfr regulates a mitotic stress pathway through its RING-finger domain with ubiquitin ligase activity.	UBE2D2 UBE2D3	8.77e-06	3	60	2	11912157
Pubmed	The cell polarity kinase Par1b/MARK2 activation selects specific NF-kB transcripts via phosphorylation of core mediator Med17/TRAP80.	PRKCI MARK2	8.77e-06	3	60	2	33596087
Pubmed	The ATP-dependent chromatin remodeling enzymes CHD6, CHD7, and CHD8 exhibit distinct nucleosome binding and remodeling activities.	CHD8 CHD6	8.77e-06	3	60	2	28533432
Pubmed	HERC2 is an E3 ligase that targets BRCA1 for degradation.	UBE2D3 HERC2	8.77e-06	3	60	2	20631078
Pubmed	In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.	EPHX2 FLNA UBE2D2 UBE2D3 ATP8A1 PXDN POTEJ PATJ MUC4 GAA	1.36e-05	1070	60	10	23533145
Pubmed	Physical and functional interactions between ZIP kinase and UbcH5.	UBE2D2 UBE2D3	1.75e-05	4	60	2	18515077
Pubmed	E6-AP/UBE3A protein acts as a ubiquitin ligase toward SOX9 protein.	UBE2D3 HERC1	1.75e-05	4	60	2	24155239
Pubmed	Intrinsic flexibility of ubiquitin on proliferating cell nuclear antigen (PCNA) in translesion synthesis.	UBE2D3 POLH	1.75e-05	4	60	2	22989887
Pubmed	The ubiquitin-specific protease USP8 directly deubiquitinates SQSTM1/p62 to suppress its autophagic activity.	UBE2D2 UBE2D3	1.75e-05	4	60	2	31241013
Pubmed	Enzymes catalyzing ubiquitination and proteolytic processing of the p105 precursor of nuclear factor kappaB1.	UBE2D2 UBE2D3	1.75e-05	4	60	2	9535861
Pubmed	Molecular basis for the association of human E4B U box ubiquitin ligase with E2-conjugating enzymes UbcH5c and Ubc4.	UBE2D2 UBE2D3	1.75e-05	4	60	2	20696396
Pubmed	Expression dynamics of Mage family genes during self-renewal and differentiation of mouse pluripotent stem and teratocarcinoma cells.	MAGEA1 MAGEB1 DDX4	2.57e-05	33	60	3	31143371
Pubmed	ADP-ribosylation factor domain protein 1 (ARD1), a multifunctional protein with ubiquitin E3 ligase, GAP, and ARF domains.	UBE2D2 UBE2D3	2.92e-05	5	60	2	16413270
Pubmed	E3 ubiquitin ligase activity of the trifunctional ARD1 (ADP-ribosylation factor domain protein 1).	UBE2D2 UBE2D3	2.92e-05	5	60	2	15684077
Pubmed	Systematic E2 screening reveals a UBE2D-RNF138-CtIP axis promoting DNA repair.	UBE2D2 UBE2D3	2.92e-05	5	60	2	26502057
Pubmed	The RING domain of mitochondrial E3 ubiquitin ligase 1 and its complex with Ube2D2: crystallization and X-ray diffraction.	UBE2D2 UBE2D3	2.92e-05	5	60	2	31929179
Pubmed	Activity-enhancing mutations in an E3 ubiquitin ligase identified by high-throughput mutagenesis.	UBE2D2 UBE2D3	2.92e-05	5	60	2	23509263
Pubmed	A novel family of bromodomain genes.	BAZ2A BAZ2B	2.92e-05	5	60	2	10662543
Pubmed	Identification of the ubiquitin carrier proteins, E2s, involved in signal-induced conjugation and subsequent degradation of IkappaBalpha.	UBE2D2 UBE2D3	2.92e-05	5	60	2	10329681
Pubmed	A ubiquitin shuttle DC-UbP/UBTD2 reconciles protein ubiquitination and deubiquitination via linking UbE1 and USP5 enzymes.	USP5 UBE2D3	2.92e-05	5	60	2	25207809
Pubmed	Allosteric activation of the RNF146 ubiquitin ligase by a poly(ADP-ribosyl)ation signal.	UBE2D2 UBE2D3	2.92e-05	5	60	2	25327252
Pubmed	The RING-H2 protein RNF11 is overexpressed in breast cancer and is a target of Smurf2 E3 ligase.	UBE2D2 UBE2D3	2.92e-05	5	60	2	14562029
Pubmed	The von Hippel-Lindau tumor suppressor protein mediates ubiquitination of activated atypical protein kinase C.	UBE2D2 PRKCI	2.92e-05	5	60	2	11574546
Pubmed	Tripartite motif ligases catalyze polyubiquitin chain formation through a cooperative allosteric mechanism.	UBE2D2 UBE2D3	2.92e-05	5	60	2	23408431
Pubmed	A cancer-associated RING finger protein, RNF43, is a ubiquitin ligase that interacts with a nuclear protein, HAP95.	UBE2D2 UBE2D3	2.92e-05	5	60	2	18313049
Pubmed	Mitochondrial ubiquitin ligase MITOL ubiquitinates mutant SOD1 and attenuates mutant SOD1-induced reactive oxygen species generation.	UBE2D2 UBE2D3	2.92e-05	5	60	2	19741096
Pubmed	Identification of a human ubiquitin-conjugating enzyme that mediates the E6-AP-dependent ubiquitination of p53.	UBE2D2 UBE2D3	2.92e-05	5	60	2	8090726
Pubmed	Enzymatic analysis of WWP2 E3 ubiquitin ligase using protein microarrays identifies autophagy-related substrates.	USP5 UBE2D2 UBE2D3	3.94e-05	38	60	3	35331737
Pubmed	Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating enzymes.	UBE2D2 UBE2D3	4.37e-05	6	60	2	9990509
Pubmed	Role of E2-RING Interactions in Governing RNF4-Mediated Substrate Ubiquitination.	UBE2D2 UBE2D3	4.37e-05	6	60	2	27678051
Pubmed	aPKC acts upstream of PAR-1b in both the establishment and maintenance of mammalian epithelial polarity.	PRKCI MARK2	4.37e-05	6	60	2	15324659
Pubmed	Positive regulation of p53 stability and activity by the deubiquitinating enzyme Otubain 1.	UBE2D2 UBE2D3	4.37e-05	6	60	2	22124327
Pubmed	Regulation of p53 by the ubiquitin-conjugating enzymes UbcH5B/C in vivo.	UBE2D2 UBE2D3	4.37e-05	6	60	2	15280377
Pubmed	Negative regulation of the RLH signaling by the E3 ubiquitin ligase RNF114.	UBE2D2 UBE2D3	4.37e-05	6	60	2	28625874
Pubmed	h-Goliath, paralog of GRAIL, is a new E3 ligase protein, expressed in human leukocytes.	UBE2D2 UBE2D3	4.37e-05	6	60	2	16549277
Pubmed	The E3 ubiquitin ligase TRIM32 regulates myoblast proliferation by controlling turnover of NDRG2.	UBE2D2 UBE2D3	4.37e-05	6	60	2	25701873
Pubmed	Trim17-mediated ubiquitination and degradation of Mcl-1 initiate apoptosis in neurons.	UBE2D2 UBE2D3	4.37e-05	6	60	2	22976837
Pubmed	The signaling adaptor GAB1 regulates cell polarity by acting as a PAR protein scaffold.	PRKCI MARK2	4.37e-05	6	60	2	22883624
Pubmed	NEDD4 regulates ubiquitination and stability of the cell adhesion molecule IGPR-1 via lysosomal pathway.	UBE2D2 UBE2D3	4.37e-05	6	60	2	33962630
Pubmed	In vivo CRISPR screening identifies BAZ2 chromatin remodelers as druggable regulators of mammalian liver regeneration.	BAZ2A BAZ2B	4.37e-05	6	60	2	35090595
Pubmed	Znf179 E3 ligase-mediated TDP-43 polyubiquitination is involved in TDP-43- ubiquitinated inclusions (UBI) (+)-related neurodegenerative pathology.	UBE2D2 UBE2D3	4.37e-05	6	60	2	30404641
Pubmed	Lysine 63-linked polyubiquitination of the dopamine transporter requires WW3 and WW4 domains of Nedd4-2 and UBE2D ubiquitin-conjugating enzymes.	UBE2D2 UBE2D3	6.11e-05	7	60	2	20051513
Pubmed	A ubiquitin ligase complex assembles linear polyubiquitin chains.	UBE2D2 UBE2D3	6.11e-05	7	60	2	17006537
Pubmed	Measuring rates of ubiquitin chain formation as a functional readout of ligase activity.	UBE2D2 UBE2D3	6.11e-05	7	60	2	22350887
Pubmed	In Vitro Analysis of E3 Ubiquitin Ligase Function.	UBE2D2 UBE2D3	6.11e-05	7	60	2	34057440
Pubmed	Monoubiquitination promotes calpain cleavage of the protein phosphatase 2A (PP2A) regulatory subunit α4, altering PP2A stability and microtubule-associated protein phosphorylation.	UBE2D2 UBE2D3	6.11e-05	7	60	2	22613722
Pubmed	Lys-63-linked ubiquitination by E3 ubiquitin ligase Nedd4-1 facilitates endosomal sequestration of internalized α-synuclein.	UBE2D2 UBE2D3	6.11e-05	7	60	2	24831002
Pubmed	UbcH8 regulates ubiquitin and ISG15 conjugation to RIG-I.	UBE2D2 UBE2D3	6.11e-05	7	60	2	17719635
Pubmed	The ancestral gene for transcribed, low-copy repeats in the Prader-Willi/Angelman region encodes a large protein implicated in protein trafficking, which is deficient in mice with neuromuscular and spermiogenic abnormalities.	HERC2 HERC1	6.11e-05	7	60	2	9949213
Pubmed	Analysis of the Zn-Binding Domains of TRIM32, the E3 Ubiquitin Ligase Mutated in Limb Girdle Muscular Dystrophy 2H.	UBE2D2 UBE2D3	6.11e-05	7	60	2	30884854
Pubmed	Cooperation of HECT-domain ubiquitin ligase hHYD and DNA topoisomerase II-binding protein for DNA damage response.	UBE2D2 UBE2D3	6.11e-05	7	60	2	11714696
Pubmed	The IDOL-UBE2D complex mediates sterol-dependent degradation of the LDL receptor.	UBE2D2 UBE2D3	6.11e-05	7	60	2	21685362
Pubmed	RNF122: a novel ubiquitin ligase associated with calcium-modulating cyclophilin ligand.	UBE2D2 UBE2D3	6.11e-05	7	60	2	20553626
Pubmed	The E3 ubiquitin ligase MID1 catalyzes ubiquitination and cleavage of Fu.	UBE2D2 UBE2D3	6.11e-05	7	60	2	25278022
Pubmed	Ubiquitylation of p62/sequestosome1 activates its autophagy receptor function and controls selective autophagy upon ubiquitin stress.	UBE2D2 UBE2D3	6.11e-05	7	60	2	28322253
Pubmed	Priming and extending: a UbcH5/Cdc34 E2 handoff mechanism for polyubiquitination on a SCF substrate.	UBE2D2 UBE2D3	6.11e-05	7	60	2	20347421
Pubmed	Bifunctional apoptosis regulator (BAR), an endoplasmic reticulum (ER)-associated E3 ubiquitin ligase, modulates BI-1 protein stability and function in ER Stress.	UBE2D2 UBE2D3	6.11e-05	7	60	2	21068390
Pubmed	The E3 Ubiquitin Ligase NEDD4L Targets OGG1 for Ubiquitylation and Modulates the Cellular DNA Damage Response.	UBE2D2 UBE2D3	6.11e-05	7	60	2	33282879
Pubmed	Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome.	MAGEA1 LENG8 LEMD3 BUB1 MARK2	6.26e-05	242	60	5	34011540
Pubmed	Functional proteomics mapping of a human signaling pathway.	FLNA USP5 UBE2D2 LEMD3 CHD6 HERC2 HERC1	6.99e-05	591	60	7	15231748
Pubmed	Structure and catalytic activation of the TRIM23 RING E3 ubiquitin ligase.	UBE2D2 UBE2D3	8.14e-05	8	60	2	28681414
Pubmed	The mechanism of neural precursor cell expressed developmentally down-regulated 4-2 (Nedd4-2)/NEDD4L-catalyzed polyubiquitin chain assembly.	UBE2D2 UBE2D3	8.14e-05	8	60	2	28972136
Pubmed	Ube2W conjugates ubiquitin to α-amino groups of protein N-termini.	UBE2D2 UBE2D3	8.14e-05	8	60	2	23560854
Pubmed	Hypoxia-associated factor, a novel E3-ubiquitin ligase, binds and ubiquitinates hypoxia-inducible factor 1alpha, leading to its oxygen-independent degradation.	UBE2D2 UBE2D3	8.14e-05	8	60	2	18838541
Pubmed	Targeting of KRAS mutant tumors by HSP90 inhibitors involves degradation of STK33.	USP5 HERC2	8.14e-05	8	60	2	22451720
Pubmed	MID1 catalyzes the ubiquitination of protein phosphatase 2A and mutations within its Bbox1 domain disrupt polyubiquitination of alpha4 but not of PP2Ac.	UBE2D2 UBE2D3	8.14e-05	8	60	2	25207814
Pubmed	E2~Ub conjugates regulate the kinase activity of Shigella effector OspG during pathogenesis.	UBE2D2 UBE2D3	8.14e-05	8	60	2	24446487
Pubmed	Involvement of Rabring7 in EGF receptor degradation as an E3 ligase.	UBE2D2 UBE2D3	8.14e-05	8	60	2	17462600
Pubmed	A novel route for F-box protein-mediated ubiquitination links CHIP to glycoprotein quality control.	UBE2D2 UBE2D3	8.14e-05	8	60	2	16682404
Pubmed	Cbl-c suppresses v-Src-induced transformation through ubiquitin-dependent protein degradation.	UBE2D2 UBE2D3	8.14e-05	8	60	2	14661060
Pubmed	The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity.	UBE2D2 UBE2D3	8.14e-05	8	60	2	12670957
Pubmed	Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53.	UBE2D2 UBE2D3	8.14e-05	8	60	2	15247280
Pubmed	AMOTL2 mono-ubiquitination by WWP1 promotes contact inhibition by facilitating LATS activation.	UBE2D3 PATJ	8.14e-05	8	60	2	34404733
Pubmed	Inhibition of UVSSA ubiquitination suppresses transcription-coupled nucleotide excision repair deficiency caused by dissociation from USP7.	UBE2D2 UBE2D3	8.14e-05	8	60	2	29323787
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	FLNA POLH BUB1 CHD8 CHD6 MRTFA	8.42e-05	418	60	6	34709266
Pubmed	Cellular inhibitor of apoptosis 1 and 2 are ubiquitin ligases for the apoptosis inducer Smac/DIABLO.	UBE2D2 UBE2D3	1.05e-04	9	60	2	12525502
Pubmed	Neph-Nephrin proteins bind the Par3-Par6-atypical protein kinase C (aPKC) complex to regulate podocyte cell polarity.	PRKCI MARK2	1.05e-04	9	60	2	18562307
Pubmed	Negative regulation of the RIG-I signaling by the ubiquitin ligase RNF125.	UBE2D2 UBE2D3	1.05e-04	9	60	2	17460044
Pubmed	Comparison of Cross-Regulation by Different OTUB1:E2 Complexes.	UBE2D2 UBE2D3	1.05e-04	9	60	2	32049508
Pubmed	TRAF-interacting protein (TRIP) is a RING-dependent ubiquitin ligase.	UBE2D2 UBE2D3	1.05e-04	9	60	2	17544371
Pubmed	Negative Regulation of CARD11 Signaling and Lymphoma Cell Survival by the E3 Ubiquitin Ligase RNF181.	UBE2D2 UBE2D3	1.05e-04	9	60	2	26711259
Pubmed	Atypical protein kinase C is involved in the evolutionarily conserved par protein complex and plays a critical role in establishing epithelia-specific junctional structures.	PRKCI MARK2	1.05e-04	9	60	2	11257119
Pubmed	Bag1 directly routes immature BCR-ABL for proteasomal degradation.	UBE2D2 UBE2D3	1.31e-04	10	60	2	20675402
Pubmed	Mechanism and chain specificity of RNF216/TRIAD3, the ubiquitin ligase mutated in Gordon Holmes syndrome.	UBE2D2 UBE2D3	1.31e-04	10	60	2	31087003
Pubmed	E2 conjugating enzyme selectivity and requirements for function of the E3 ubiquitin ligase CHIP.	UBE2D2 UBE2D3	1.31e-04	10	60	2	21518764
Pubmed	Targeting ubiquitin conjugating enzyme UbcH5b by a triterpenoid PC3-15 from Schisandra plants sensitizes triple-negative breast cancer cells to lapatinib.	UBE2D2 UBE2D3	1.31e-04	10	60	2	33607208
Pubmed	Osmotic and heat stress-dependent regulation of MLK4β and MLK3 by the CHIP E3 ligase in ovarian cancer cells.	UBE2D2 UBE2D3	1.31e-04	10	60	2	28757353
Pubmed	A dimer-monomer switch controls CHIP-dependent substrate ubiquitylation and processing.	UBE2D2 UBE2D3	1.59e-04	11	60	2	36027913
Pubmed	Reconstruction of an active SOCS3-based E3 ubiquitin ligase complex in vitro: identification of the active components and JAK2 and gp130 as substrates.	UBE2D2 UBE2D3	1.59e-04	11	60	2	24438103
Interaction	RNF166 interactions	MAGEA1 PARP11 UBE2D2 UBE2D3 HERC2 PATJ	2.40e-07	91	58	6	int:RNF166
Cytoband	2p25	PXDN ODC1	2.54e-04	18	60	2	2p25
GeneFamily	Zinc fingers CXXC-type\|Methyl-CpG binding domain containing	BAZ2A BAZ2B	2.59e-04	11	40	2	1025
GeneFamily	CD molecules\|Mucins	OVGP1 MUC4	9.76e-04	21	40	2	648
GeneFamily	MAGE family	MAGEA1 MAGEB1	3.53e-03	40	40	2	1136
GeneFamily	Ubiquitin conjugating enzymes E2	UBE2D2 UBE2D3	3.71e-03	41	40	2	102
GeneFamily	PHD finger proteins	BAZ2A BAZ2B	1.69e-02	90	40	2	88
Coexpression	GSE41978_ID2_KO_AND_BIM_KO_VS_BIM_KO_KLRG1_LOW_EFFECTOR_CD8_TCELL_DN	LEMD3 BAZ2B POLH C11orf68 ODC1 MUC4	6.32e-06	199	60	6	M9567
ToppCell	Adult-Epithelial-club_cell-D231\|Adult / Lineage, Cell type, age group and donor	SLC6A1 HCAR1 SLC39A6 PATJ MUC4	5.33e-06	187	60	5	ee59d7d3de5879738ff0b9c3ea5e4847fb48cb86
ToppCell	human_hepatoblastoma-Tumor_cells\|human_hepatoblastoma / Sample and Cell Type and Tumor Cluster (all cells)	EPHX2 RALGPS2 CHD6 PATJ TMEM117	6.22e-06	193	60	5	503a979328c68b096680b71359a26f02fafdff35
Disease	3-hydroxyisobutyrate measurement	LVRN PARP11	4.91e-05	6	54	2	EFO_0010983
Disease	CHARGE syndrome (implicated_via_orthology)	CHD8 CHD6	6.86e-05	7	54	2	DOID:0050834 (implicated_via_orthology)
Disease	beta-defensin 1 measurement	LVRN MAP4K5	1.47e-04	10	54	2	EFO_0801415
Disease	Macrocephaly	CHD8 ODC1	1.79e-04	11	54	2	C0221355
Disease	ferritin measurement	BAZ2B MAP4K5 OTOP3	1.37e-03	119	54	3	EFO_0004459
Disease	eosinophil count	UBR2 FLNA UBE2D3 PXDN MAP4K5 C11orf68 CPO PRKCI ZNF568	1.40e-03	1488	54	9	EFO_0004842
Disease	Astigmatism	LVRN CHD6 HERC2	1.72e-03	129	54	3	HP_0000483
Disease	response to vaccine, cytokine measurement	UBE2D2 ATP8A1 SLC4A5	1.80e-03	131	54	3	EFO_0004645, EFO_0004873

Protein segments in the cluster

Peptide	Gene	Start	Entry
GMDVPLAMEEWHHER	PI16	96	Q6UXB8
MDHENMFWYRQDPGL	TRBV28	46	A0A5B6
MPEGLDPLVWNHFCM	CFAP43	1361	Q8NDM7
ELEMWLQGHPEFAVD	CHD8	2336	Q9HCK8
MHEFHKFWIEEDPMD	ELMOD1	281	Q8N336
DLADYWIKPGDHVMM	PRMT9	441	Q6P2P2
DMWNEFFHVMLNIPD	BUB1	1026	O43683
MGDEDWEAEINPHMS	DDX4	1	Q9NQI0
FIIEAPGHMSDVEWM	CCDC62	521	Q6P9F0
LMEMESHDAAWPFLE	BAZ2A	1806	Q9UIF9
MILTEMETHEDAWPF	BAZ2B	2071	Q9UIF8
FDNHAMENWGLMIFD	LVRN	376	Q6Q4G3
HPMGEIYEWMREISE	CPO	51	Q8IVL8
WDLDMHYEPTDTAAM	ATP8A1	376	Q9Y2Q0
MFDPVMEIGDQWHLA	LEMD3	791	Q9Y2U8
PEEMLFHFGMTWQIN	MUC4	4861	Q99102
LWMMPAFGIHPEFEN	OTOP3	541	Q7RTS5
IQGHPFFRNVDWDMM	PRKCI	516	P41743
MIAMEGGHAPEEEIW	MAGEA1	201	P43355
DPVAWEAGMLMHFIL	MAGEB1	106	P43366
ELWMQLHEAGMGLEE	GPAA1	391	O43292
DDHEELAWPGIMESF	HERC2	1181	O95714
ENGMETPMHENPEWE	LENG8	26	Q96PV6
TVLAMWMIEHPGHED	HERC1	2786	Q15751
PMVHMLWAAFEEQQG	PRPF39	421	Q86UA1
MWEANPEMFHKAEEL	PARP11	1	Q9NR21
DGEVMPTLDMALFDW	DRAXIN	221	Q8NBI3
DFVLVPQMSQHMEDW	EPHX2	496	P34913
MEELLPDGQIWANMD	HYLS1	1	Q96M11
KHMERWMHGLENDEF	CHD6	1941	Q8TD26
WMHGLENDEFEIEKP	CHD6	1946	Q8TD26
LHYSISMPMWDEEED	FLNA	146	P21333
DPQMWDFDDLNFTGM	CXCR1	6	P25024
FHDQVPFDGMWIDMN	GAA	506	P10253
MHGTPGHEDFVQWEM	MARK2	736	Q7KZI7
MFPRGAEAQDWHLDM	KLHDC7A	1	Q5VTJ3
WHDIMFQLEFFMPLG	HCAR1	176	Q9BXC0
DLPEMHVGDWMLFEN	ODC1	371	P11926
DEMGLSSDPNFMLQW	MAP4K5	356	Q9Y4K4
REHFGGAMVWTLDMD	OVGP1	346	Q12889
GWMVMMADDPEHPDL	RALGPS2	521	Q86X27
EFWERNMHQMTDGLD	SLC6A1	191	P30531
KYPMEHGIITNWDDM	POTEJ	731	P0CG39
SDSGLLPRWHMMDFF	SCN5A	871	Q14524
LVPVWDMPEHMDYHF	POLH	641	Q9Y253
DLIWAAQAFMMAHPE	SPATA25	176	Q9BR10
MDMADEPLNGSHTWL	SSTR2	1	P30874
MGLDLADGHLDSMDW	MRTFA	876	Q969V6
AWMVIMGDGLHNFSD	SLC39A6	596	Q13433
YLVDEDPERMNEHWM	CHST14	266	Q8NCH0
DPERMNEHWMPVYHL	CHST14	271	Q8NCH0
LAAEAMAADMDPWLV	C11orf68	66	Q9H3H3
VGDDMFHWQATIMGP	UBE2D2	26	P62837
PWVMEEEMFGRHCPE	ZNF568	106	Q3ZCX4
WEMHEFLTPRLQEMD	PATJ	851	Q8NI35
HMLMQWGQFLDHDLD	PXDN	816	Q92626
VGDDMFHWQATIMGP	UBE2D3	26	P61077
GEMPAMHEIGEELIW	SLC4A5	476	Q9BY07
LLIVMQDWEFPHFMG	TMEM117	251	Q9H0C3
EDMLAQHVLLGPMEW	UBR2	61	Q8IWV8
IDHLMVMFGETPSWD	TTC4	301	O95801
WVMSHMDDPDFANPL	USP5	691	P45974