Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	ciliary pocket membrane	EHD1 EHD3	3.31e-05	3	70	2	GO:0020018
GeneOntologyCellularComponent	ciliary pocket	EHD1 EHD3	3.31e-05	3	70	2	GO:0020016
Domain	EHD_N	EHD1 EHD3 EHD2	4.80e-07	5	69	3	IPR031692
Domain	EHD_N	EHD1 EHD3 EHD2	4.80e-07	5	69	3	PF16880
Domain	Spectrin_repeat	SYNE3 SPTAN1 ACTN1 PPL	3.78e-06	29	69	4	IPR002017
Domain	Spectrin/alpha-actinin	SYNE3 SPTAN1 ACTN1 PPL	5.67e-06	32	69	4	IPR018159
Domain	SPEC	SYNE3 SPTAN1 ACTN1 PPL	5.67e-06	32	69	4	SM00150
Domain	EF-hand_4	EHD1 EHD3 EHD2	5.68e-06	10	69	3	PF12763
Domain	EH	EHD1 EHD3 EHD2	7.80e-06	11	69	3	PS50031
Domain	EH	EHD1 EHD3 EHD2	7.80e-06	11	69	3	SM00027
Domain	EH_dom	EHD1 EHD3 EHD2	7.80e-06	11	69	3	IPR000261
Domain	EHD1/EHD3	EHD1 EHD3	1.35e-05	2	69	2	IPR029951
Domain	G_DYNAMIN_dom	EHD1 EHD3 EHD2	1.71e-05	14	69	3	IPR030381
Domain	G_DYNAMIN_2	EHD1 EHD3 EHD2	1.71e-05	14	69	3	PS51718
Domain	Dynamin_GTPase	EHD1 EHD3 EHD2	2.13e-05	15	69	3	IPR001401
Domain	Dynamin_N	EHD1 EHD3 EHD2	2.13e-05	15	69	3	PF00350
Domain	Dynamin_SF	EHD1 EHD3 EHD2	2.13e-05	15	69	3	IPR022812
Domain	Spectrin	SYNE3 SPTAN1 ACTN1	8.11e-05	23	69	3	PF00435
Domain	EF-hand_Ca_insen	SPTAN1 ACTN1	2.00e-04	6	69	2	IPR014837
Domain	EFhand_Ca_insen	SPTAN1 ACTN1	2.00e-04	6	69	2	PF08726
Domain	DHC_N1	DNAH5 DYNC1H1	3.71e-04	8	69	2	PF08385
Domain	Dynein_heavy_dom-1	DNAH5 DYNC1H1	3.71e-04	8	69	2	IPR013594
Domain	-	TTF2 DDX31 EHD1 RNF213 CHD8 CHST7 DNAH5 DYNC1H1 EHD3 EHD2	3.92e-04	746	69	10	3.40.50.300
Domain	-	SPTAN1 EHD1 ACTN1 STAT3 EHD3 EHD2	4.04e-04	261	69	6	1.10.238.10
Domain	EF_Hand_1_Ca_BS	SPTAN1 EHD1 ACTN1 EHD3 EHD2	4.72e-04	175	69	5	IPR018247
Domain	EF-hand-dom_pair	SPTAN1 EHD1 ACTN1 STAT3 EHD3 EHD2	6.65e-04	287	69	6	IPR011992
Domain	aa-tRNA-synt_IIb	EIF2AK4 TARS2	7.24e-04	11	69	2	IPR002314
Domain	tRNA-synt_2b	EIF2AK4 TARS2	7.24e-04	11	69	2	PF00587
Domain	-	EIF2AK4 TARS2	7.24e-04	11	69	2	3.40.50.800
Domain	EF_HAND_1	SPTAN1 EHD1 ACTN1 EHD3 EHD2	9.44e-04	204	69	5	PS00018
Domain	START	STARD13 STARD8	1.02e-03	13	69	2	SM00234
Domain	P-loop_NTPase	TTF2 DDX31 EHD1 RNF213 CHD8 CHST7 DNAH5 DYNC1H1 EHD3 EHD2	1.06e-03	848	69	10	IPR027417
Domain	Dynein_heavy_chain_D4_dom	DNAH5 DYNC1H1	1.19e-03	14	69	2	IPR024317
Domain	Dynein_HC_stalk	DNAH5 DYNC1H1	1.19e-03	14	69	2	IPR024743
Domain	Dynein_heavy_dom-2	DNAH5 DYNC1H1	1.19e-03	14	69	2	IPR013602
Domain	DHC_N2	DNAH5 DYNC1H1	1.19e-03	14	69	2	PF08393
Domain	MT	DNAH5 DYNC1H1	1.19e-03	14	69	2	PF12777
Domain	AAA_8	DNAH5 DYNC1H1	1.19e-03	14	69	2	PF12780
Domain	ATPase_dyneun-rel_AAA	DNAH5 DYNC1H1	1.19e-03	14	69	2	IPR011704
Domain	Anticodon-bd	EIF2AK4 TARS2	1.19e-03	14	69	2	IPR004154
Domain	AAA_5	DNAH5 DYNC1H1	1.19e-03	14	69	2	PF07728
Domain	DHC_fam	DNAH5 DYNC1H1	1.37e-03	15	69	2	IPR026983
Domain	START	STARD13 STARD8	1.37e-03	15	69	2	PF01852
Domain	START_lipid-bd_dom	STARD13 STARD8	1.37e-03	15	69	2	IPR002913
Domain	Dynein_heavy_dom	DNAH5 DYNC1H1	1.37e-03	15	69	2	IPR004273
Domain	START	STARD13 STARD8	1.37e-03	15	69	2	PS50848
Domain	Dynein_heavy	DNAH5 DYNC1H1	1.37e-03	15	69	2	PF03028
Domain	EF_HAND_2	SPTAN1 EHD1 ACTN1 EHD3 EHD2	1.64e-03	231	69	5	PS50222
Domain	EF_hand_dom	SPTAN1 EHD1 ACTN1 EHD3 EHD2	1.67e-03	232	69	5	IPR002048
Domain	aa-tRNA-synth_II	EIF2AK4 TARS2	1.98e-03	18	69	2	IPR006195
Domain	AA_TRNA_LIGASE_II	EIF2AK4 TARS2	1.98e-03	18	69	2	PS50862
Domain	EF-hand_1	SPTAN1 EHD1 ACTN1 EHD3	2.42e-03	152	69	4	PF00036
Domain	SH3_9	RIMBP3 SH3D19 MAP3K11	3.01e-03	78	69	3	PF14604
Domain	-	STARD13 STARD8	3.24e-03	23	69	2	3.30.530.20
Domain	START-like_dom	STARD13 STARD8	3.24e-03	23	69	2	IPR023393
Pathway	REACTOME_BUTYROPHILIN_BTN_FAMILY_INTERACTIONS	BTN2A2 BTN2A1 PPL	4.39e-06	9	54	3	MM15487
Pathway	REACTOME_BUTYROPHILIN_BTN_FAMILY_INTERACTIONS	BTN2A2 BTN2A1 PPL	1.14e-05	12	54	3	M27738
Pathway	REACTOME_DISINHIBITION_OF_SNARE_FORMATION	STXBP3 PRKCA	1.43e-04	5	54	2	M26920
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	TTF2 BPTF WDR33 SPTAN1 SH3D19 CCDC85C CHD8 ACTN1 PRPF40A DYNC1H1 STAT3	1.28e-08	549	70	11	38280479
Pubmed	C-terminal EH-domain-containing proteins: consensus for a role in endocytic trafficking, EH?	EHD1 EHD3 EHD2	3.12e-08	4	70	3	16155252
Pubmed	Rabenosyn-5 and EHD1 interact and sequentially regulate protein recycling to the plasma membrane.	EHD1 EHD3 EHD2	3.12e-08	4	70	3	15020713
Pubmed	Shared as well as distinct roles of EHD proteins revealed by biochemical and functional comparisons in mammalian cells and C. elegans.	EHD1 EHD3 EHD2	3.12e-08	4	70	3	17233914
Pubmed	EHD2, EHD3, and EHD4 encode novel members of a highly conserved family of EH domain-containing proteins.	EHD1 EHD3 EHD2	3.12e-08	4	70	3	10673336
Pubmed	EH domain proteins regulate cardiac membrane protein targeting.	EHD1 EHD3 EHD2	7.79e-08	5	70	3	20489164
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	DDX31 SYNE3 STXBP3 PIEZO1 SPTAN1 MTR VARS2 EBNA1BP2 MAP7 NCLN TARS2 HSPA12B DNAJC3 TOP3B PRPF40A	2.14e-07	1487	70	15	33957083
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	TTF2 CLASP1 WDR33 SPTAN1 EHD1 CHD8 EBNA1BP2 MAP7 PRPF40A DYNC1H1	2.57e-07	582	70	10	20467437
Pubmed	Defining the membrane proteome of NK cells.	SYNE3 CLASP1 NBEAL2 EHD1 MAP3K11 RNF213 EIF3D NCLN FUT7 DNAJC3 G6PD PRPF40A DYNC1H1	5.19e-07	1168	70	13	19946888
Pubmed	The endocytic recycling regulatory protein EHD1 Is required for ocular lens development.	EHD1 EHD3 EHD2	1.27e-06	11	70	3	26455409
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	TNRC18 LRFN1 SYNE3 NBEAL2 PIEZO1 SREBF1 MAP3K11 CHD8 PKN1 NCLN TOP3B DYNC1H1	1.94e-06	1105	70	12	35748872
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	NEFH LRFN1 CLASP1 SPTAN1 SH3D19 PRKCA CHD8 PKN1 TOP3B DYNC1H1 EHD3	3.37e-06	963	70	11	28671696
Pubmed	Pathological shear stress stimulates the tyrosine phosphorylation of alpha-actinin associated with the glycoprotein Ib-IX complex.	PKN1 ACTN1	3.99e-06	2	70	2	11802708
Pubmed	STAT3 and PKC differentially regulate telomerase activity during megakaryocytic differentiation of K562 cells.	PRKCA STAT3	3.99e-06	2	70	2	17525530
Pubmed	SUMOylation of EHD3 Modulates Tubulation of the Endocytic Recycling Compartment.	EHD1 EHD3	3.99e-06	2	70	2	26226295
Pubmed	VARS2 and TARS2 mutations in patients with mitochondrial encephalomyopathies.	VARS2 TARS2	3.99e-06	2	70	2	24827421
Pubmed	Elevated G6PD expression contributes to migration and invasion of hepatocellular carcinoma cells by inducing epithelial-mesenchymal transition.	G6PD STAT3	3.99e-06	2	70	2	29471502
Pubmed	The specific PKC-α inhibitor chelerythrine blunts costunolide-induced eryptosis.	PRKCA G6PD	3.99e-06	2	70	2	32638182
Pubmed	G6PD downregulation triggered growth inhibition and induced apoptosis by regulating STAT3 signaling pathway in esophageal squamous cell carcinoma.	G6PD STAT3	3.99e-06	2	70	2	26250461
Pubmed	Variant G6PD levels promote tumor cell proliferation or apoptosis via the STAT3/5 pathway in the human melanoma xenograft mouse model.	G6PD STAT3	3.99e-06	2	70	2	23693134
Pubmed	Human transcription factor protein interaction networks.	BPTF DDX31 WDR33 SPTAN1 MTR CCDC85C CHD8 EIF3D EBNA1BP2 MAP7 PRPF40A DYNC1H1 STAT3	4.82e-06	1429	70	13	35140242
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	BPTF DDX31 SPTAN1 CHD8 ACTN1 EIF3D EBNA1BP2 PRPF40A DYNC1H1	6.44e-06	653	70	9	22586326
Pubmed	Expanding the Interactome of TES by Exploiting TES Modules with Different Subcellular Localizations.	SPTAN1 PRKCA ACTN1 EBNA1BP2 DYNC1H1 STAT3	8.16e-06	235	70	6	28378594
Pubmed	PKN associates and phosphorylates the head-rod domain of neurofilament protein.	NEFH PKN1	1.20e-05	3	70	2	8621664
Pubmed	Prothymosin α promotes colorectal carcinoma chemoresistance through inducing lipid droplet accumulation.	SREBF1 STAT3	1.20e-05	3	70	2	33872798
Pubmed	Synaptic adhesion-like molecules (SALMs) promote neurite outgrowth.	LRFN1 LRFN3	1.20e-05	3	70	2	18585462
Pubmed	Protein kinase C regulates rod photoreceptor differentiation through modulation of STAT3 signaling.	PRKCA STAT3	1.20e-05	3	70	2	20237998
Pubmed	Endocytic recycling proteins EHD1 and EHD2 interact with fer-1-like-5 (Fer1L5) and mediate myoblast fusion.	EHD1 EHD2	1.20e-05	3	70	2	21177873
Pubmed	Early steps in primary cilium assembly require EHD1/EHD3-dependent ciliary vesicle formation.	EHD1 EHD3	1.20e-05	3	70	2	25686250
Pubmed	Dysregulation of sterol regulatory element binding protein-1c in livers of morbidly obese women is associated with altered suppressor of cytokine signaling-3 and signal transducer and activator of transcription-1 signaling.	SREBF1 STAT3	1.20e-05	3	70	2	19913854
Pubmed	Interaction of PKN with alpha-actinin.	PKN1 ACTN1	1.20e-05	3	70	2	9030526
Pubmed	Butyrophilin 2a2 (Btn2a2) expression on thymic epithelial cells promotes central T cell tolerance and prevents autoimmune disease.	BTN2A2 BTN2A1	1.20e-05	3	70	2	37356345
Pubmed	EHD Proteins Cooperate to Generate Caveolar Clusters and to Maintain Caveolae during Repeated Mechanical Stress.	EHD1 EHD2	1.20e-05	3	70	2	28943089
Pubmed	RANKL-Induced Btn2a2 - A T Cell Immunomodulatory Molecule - During Osteoclast Differentiation Fine-Tunes Bone Resorption.	BTN2A2 BTN2A1	1.20e-05	3	70	2	34421818
Pubmed	Differential roles of C-terminal Eps15 homology domain proteins as vesiculators and tubulators of recycling endosomes.	EHD1 EHD3	1.20e-05	3	70	2	24019528
Pubmed	EHD3: a protein that resides in recycling tubular and vesicular membrane structures and interacts with EHD1.	EHD1 EHD3	1.20e-05	3	70	2	12121420
Pubmed	PIKE-A promotes glioblastoma growth by driving PPP flux through increasing G6PD expression mediated by phosphorylation of STAT3.	G6PD STAT3	1.20e-05	3	70	2	34411567
Pubmed	A muscle-specific protein 'myoferlin' modulates IL-6/STAT3 signaling by chaperoning activated STAT3 to nucleus.	STAT3 EHD2	1.20e-05	3	70	2	28745314
Pubmed	Optimized fragmentation schemes and data analysis strategies for proteome-wide cross-link identification.	NEFH SPTAN1 ACTN1 EIF3D EBNA1BP2 G6PD DYNC1H1 STAT3	1.27e-05	538	70	8	28524877
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	STARD13 TTF2 GTF2H4 SPTAN1 EHD1 PRKCA CHD8 ACTN1 EIF3D EBNA1BP2 G6PD DYNC1H1	1.51e-05	1353	70	12	29467282
Pubmed	Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry.	MAP3K11 PRKCA PKN1 EIF2AK4	1.92e-05	78	70	4	17192257
Pubmed	Interactions between EHD proteins and Rab11-FIP2: a role for EHD3 in early endosomal transport.	EHD1 EHD3	2.39e-05	4	70	2	16251358
Pubmed	Btn2a2 Regulates ILC2-T Cell Cross Talk in Type 2 Immune Responses.	BTN2A2 BTN2A1	2.39e-05	4	70	2	35145516
Pubmed	Mesenchymal stromal cell-derived CCL2 suppresses plasma cell immunoglobulin production via STAT3 inactivation and PAX5 induction.	PAX5 STAT3	2.39e-05	4	70	2	18812467
Pubmed	EHD3 Protein Is Required for Tubular Recycling Endosome Stabilization, and an Asparagine-Glutamic Acid Residue Pair within Its Eps15 Homology (EH) Domain Dictates Its Selective Binding to NPF Peptides.	EHD1 EHD3	2.39e-05	4	70	2	27189942
Pubmed	Protease-activated receptor-1 activation of endothelial cells induces protein kinase Calpha-dependent phosphorylation of syntaxin 4 and Munc18c: role in signaling p-selectin expression.	STXBP3 PRKCA	2.39e-05	4	70	2	15576373
Pubmed	Role of the EHD Family of Endocytic Recycling Regulators for TCR Recycling and T Cell Function.	EHD1 EHD3	2.39e-05	4	70	2	29212907
Pubmed	Nanomolar amyloid beta protein activates a specific PKC isoform mediating phosphorylation of MARCKS in Neuro2A cells.	PRKCA PKN1	2.39e-05	4	70	2	11930178
Pubmed	PRK1 phosphorylates MARCKS at the PKC sites: serine 152, serine 156 and serine 163.	PRKCA PKN1	2.39e-05	4	70	2	8557118
Pubmed	Coxsackievirus B3 infection activates the unfolded protein response and induces apoptosis through downregulation of p58IPK and activation of CHOP and SREBP1.	SREBF1 DNAJC3	2.39e-05	4	70	2	20554776
Pubmed	Btn2a2, a T cell immunomodulatory molecule coregulated with MHC class II genes.	BTN2A2 BTN2A1	2.39e-05	4	70	2	26809444
Pubmed	EHD proteins associate with syndapin I and II and such interactions play a crucial role in endosomal recycling.	EHD1 EHD2	2.39e-05	4	70	2	15930129
Pubmed	p58IPK is an inhibitor of the eIF2α kinase GCN2 and its localization and expression underpin protein synthesis and ER processing capacity.	EIF2AK4 DNAJC3	2.39e-05	4	70	2	25329545
Pubmed	Butyrophilin Btn2a2 inhibits TCR activation and phosphatidylinositol 3-kinase/Akt pathway signaling and induces Foxp3 expression in T lymphocytes.	BTN2A2 BTN2A1	2.39e-05	4	70	2	23589618
Pubmed	Endocytic recycling protein EHD1 regulates primary cilia morphogenesis and SHH signaling during neural tube development.	EHD1 EHD3 EHD2	2.47e-05	28	70	3	26884322
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	GTF2H4 CLASP1 WDR33 SREBF1 CCDC85C CHD8 ACTN1 EBNA1BP2 NCLN PRPF40A STAT3	2.70e-05	1203	70	11	29180619
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	SPTAN1 EHD1 PRKCA RNF213 EIF3D EBNA1BP2 MAP7 NCLN G6PD DYNC1H1 STAT3 EHD2	2.79e-05	1440	70	12	30833792
Pubmed	Targeting RICTOR Sensitizes SMAD4-Negative Colon Cancer to Irinotecan.	EHD1 MTR PKN1 EIF2AK4 DNAJC3	3.50e-05	183	70	5	31932471
Pubmed	Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy.	NEFH CLASP1 SPTAN1 RNF213 EIF3D	3.88e-05	187	70	5	26460568
Pubmed	NSD3-Short Is an Adaptor Protein that Couples BRD4 to the CHD8 Chromatin Remodeler.	BPTF CHD8	3.98e-05	5	70	2	26626481
Pubmed	Cell type-dependent pro- and anti-inflammatory role of signal transducer and activator of transcription 3 in alcoholic liver injury.	SREBF1 STAT3	3.98e-05	5	70	2	18395093
Pubmed	Selective high-level expression of epsin 3 in gastric parietal cells, where it is localized at endocytic sites of apical canaliculi.	EHD1 EHD2	3.98e-05	5	70	2	21115825
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	DDX31 STXBP3 SPTAN1 CCDC85C RNF213 EIF2AK4 TARS2 G6PD TOP3B MTMR9	4.59e-05	1049	70	10	27880917
Pubmed	The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.	TNRC18 DDX31 SPTAN1 CHD8 DNAH5 DYNC1H1	5.67e-05	332	70	6	37433992
Pubmed	MICAL-L1 links EHD1 to tubular recycling endosomes and regulates receptor recycling.	EHD1 EHD3	5.96e-05	6	70	2	19864458
Pubmed	Phosphorylation of histone H3T6 by PKCbeta(I) controls demethylation at histone H3K4.	PRKCA PKN1	5.96e-05	6	70	2	20228790
Pubmed	A NUDEL-dependent mechanism of neurofilament assembly regulates the integrity of CNS neurons.	NEFH DYNC1H1	5.96e-05	6	70	2	15208636
Pubmed	BTN1A1, the mammary gland butyrophilin, and BTN2A2 are both inhibitors of T cell activation.	BTN2A2 BTN2A1	5.96e-05	6	70	2	20208008
Pubmed	Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.	RNF213 EIF2AK4 DNAH5 PPL EHD3	6.44e-05	208	70	5	33230847
Pubmed	Comparative analysis of structure, expression and PSD95-binding capacity of Lrfn, a novel family of neuronal transmembrane proteins.	LRFN1 LRFN3	8.33e-05	7	70	2	16828986
Pubmed	Requirement for math5 in the development of retinal ganglion cells.	NEFH PRKCA	8.33e-05	7	70	2	11156601
Pubmed	The cluster of BTN genes in the extended major histocompatibility complex.	BTN2A2 BTN2A1	8.33e-05	7	70	2	11170752
Pubmed	Brain spectrin binding to the NMDA receptor is regulated by phosphorylation, calcium and calmodulin.	SPTAN1 PRKCA	8.33e-05	7	70	2	9670010
Pubmed	A novel family of adhesion-like molecules that interacts with the NMDA receptor.	LRFN1 LRFN3	8.33e-05	7	70	2	16495444
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	DDX31 CLASP1 WDR33 SPTAN1 EHD1 EIF2AK4 VARS2 EBNA1BP2 PRPF40A DYNC1H1 STAT3	8.77e-05	1371	70	11	36244648
Pubmed	N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.	BPTF SPTAN1 G6PD DYNC1H1 PPL EHD2	8.86e-05	360	70	6	33111431
Pubmed	Role of EHD1 and EHBP1 in perinuclear sorting and insulin-regulated GLUT4 recycling in 3T3-L1 adipocytes.	EHD1 EHD2	1.11e-04	8	70	2	15247266
Pubmed	M phase-specific association of human topoisomerase IIIbeta with chromosomes.	CHD8 TOP3B	1.11e-04	8	70	2	11549288
Pubmed	Myosin Vb interacts with Rab8a on a tubular network containing EHD1 and EHD3.	EHD1 EHD3	1.11e-04	8	70	2	17507647
Pubmed	mTORC1 accelerates retinal development via the immunoproteasome.	SREBF1 PRKCA STAT3	1.11e-04	46	70	3	29950673
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	STXBP3 SPTAN1 MTR EIF3D EBNA1BP2 NCLN TARS2 DNAH5 G6PD PRPF40A DYNC1H1	1.23e-04	1425	70	11	30948266
Pubmed	Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.	STXBP3 FASTKD1 EIF3D EBNA1BP2 MAP7 NCLN TARS2 STAT3	1.36e-04	754	70	8	33060197
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	STARD13 BPTF TNRC18 WDR33 SPTAN1 EIF2AK4 ACTN1 EBNA1BP2 DNAJC3 TOP3B PPL	1.37e-04	1442	70	11	35575683
Pubmed	Human platelets contain SNARE proteins and a Sec1p homologue that interacts with syntaxin 4 and is phosphorylated after thrombin activation: implications for platelet secretion.	STXBP3 PRKCA	1.42e-04	9	70	2	10194441
Pubmed	Association of insulin-like growth factor 1 receptor with EHD1 and SNAP29.	EHD1 EHD3	1.42e-04	9	70	2	11423532
Pubmed	Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.	STARD13 FASTKD1 RNF213 CHD8 VARS2 NCLN TARS2 DNAJC3 G6PD PRPF40A EHD2	1.44e-04	1451	70	11	30550785
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	TTF2 WDR33 SH3D19 FASTKD1 MTR RNF213 VARS2 EBNA1BP2 NCLN TARS2 TOP3B	1.88e-04	1496	70	11	32877691
Pubmed	Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.	EHD1 PRKCA ACTN1 G6PD EHD3	1.93e-04	263	70	5	12665801
Pubmed	Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).	ENPP3 EHD1 ACTN1 DNAJC3 DYNC1H1 PPL	1.97e-04	417	70	6	19199708
Pubmed	LINC01554-Mediated Glucose Metabolism Reprogramming Suppresses Tumorigenicity in Hepatocellular Carcinoma via Downregulating PKM2 Expression and Inhibiting Akt/mTOR Signaling Pathway.	TTF2 ACTN1 G6PD DYNC1H1	1.98e-04	142	70	4	30809309
Pubmed	Identification of different proteins binding to Na, K-ATPase α1 in LPS-induced ARDS cell model by proteomic analysis.	RNF213 NCLN G6PD DYNC1H1	2.09e-04	144	70	4	35681168
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	DDX31 WDR33 FASTKD1 EIF3D EBNA1BP2 TOP3B PRPF40A DYNC1H1	2.15e-04	807	70	8	22681889
Pubmed	Brain proteins interacting with the tetramerization region of non-erythroid alpha spectrin.	SPTAN1 AKIP1	2.17e-04	11	70	2	17607528
Pubmed	Phosphorylation of tau is regulated by PKN.	PRKCA PKN1	2.17e-04	11	70	2	11104762
Pubmed	Genetic predictors of medically refractory ulcerative colitis.	GTF2H4 VARS2	2.17e-04	11	70	2	20848476
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	BPTF SPTAN1 EBNA1BP2 MAP7 NCLN DNAJC3 G6PD TOP3B DYNC1H1 STAT3	2.61e-04	1297	70	10	33545068
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	LRFN1 STXBP3 CLASP1 FASTKD1 RNF213 CHD8 PKN1 TARS2 PRPF40A	2.71e-04	1061	70	9	33845483
Pubmed	DDX39B facilitates the malignant progression of hepatocellular carcinoma via activation of SREBP1-mediated de novo lipid synthesis.	SPTAN1 SREBF1 ACTN1	2.84e-04	63	70	3	37052853
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	STARD13 LRFN1 CLASP1 CCDC85C ACTN1 EIF3D MAP7 NCLN DYNC1H1 EHD3	3.02e-04	1321	70	10	27173435
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	RIMBP3 TTF2 STXBP3 CCDC85C PRKCA DYNC1H1 MTMR9 STAT3	3.13e-04	853	70	8	28718761
Cytoband	Ensembl 112 genes in cytogenetic band chr9q34	RALGDS DDX31 SPTAN1 FUT7	1.57e-03	325	70	4	chr9q34
GeneFamily	C2 domain containing protein kinases	PRKCA PKN1	3.06e-04	10	48	2	835
GeneFamily	Butyrophilins\|V-set domain containing\|C2-set domain containing	BTN2A2 BTN2A1	7.09e-04	15	48	2	458
GeneFamily	StAR related lipid transfer domain containing	STARD13 STARD8	7.09e-04	15	48	2	759
GeneFamily	EF-hand domain containing	SPTAN1 EHD1 EHD3 EHD2	2.69e-03	219	48	4	863
Coexpression	TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_MONOCYTE_UP	NEFH SPTAN1 FASTKD1 EBNA1BP2 NCLN EHD2	1.74e-05	203	70	6	M10184
Coexpression	MULLIGHAN_NPM1_MUTATED_SIGNATURE_1_DN	BTN2A2 SPTAN1 EHD1 EIF3D CHST7	2.15e-05	125	70	5	M19629
ToppCell	Control-Endothelial-Endothelial-Alv_Cap\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	STARD13 BTN2A2 MAP3K11 HSPA12B EHD3	1.14e-05	187	70	5	ea9d34bcd3bd1f36745846309ede349773de501a
ToppCell	control-Lymphoid-CTL\|Lymphoid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	BPTF PCSK7 RNF213 PKN1 BTN2A1	1.33e-05	193	70	5	89d407a88b5956559a589425b89b3eb8dc78e1dd
ToppCell	356C-Epithelial_cells-Epithelial-I_(AT1)-\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	TRIL NBEAL2 PIEZO1 EHD1 EHD2	1.47e-05	197	70	5	69d5b8588046d119b5dff9a7fd6f49e97e00a5b7
ToppCell	356C-Epithelial_cells-Epithelial-I_(AT1)\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	TRIL NBEAL2 PIEZO1 EHD1 EHD2	1.47e-05	197	70	5	e6cbfa267eb2e05b441fd034786faae07bb0e081
ToppCell	(7)_Epithelial_cells-(7)_Epithelial-I_(AT1)\|(7)_Epithelial_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)	TRIL NBEAL2 PIEZO1 EHD1 EHD2	1.54e-05	199	70	5	5a002d49a8b84c158f7b4d7a3e78e6a937757bb7
ToppCell	10x5'v1-week_14-16-Myeloid_neutrophil-granulo-neutrophil-myelocyte\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	NBEAL2 EHD1 PKN1 ACTN1 G6PD	1.54e-05	199	70	5	a1635a52318be0423f8e4fc03d971c28cd22b57e
ToppCell	LPS_IL1RA-Endothelial-Endothelial\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	SPTAN1 RNF213 HSPA12B DYNC1H1 EHD2	1.58e-05	200	70	5	72ea9882a8ed26fa1534aeb6ba0d1897dccc20c5
ToppCell	LPS_IL1RA-Endothelial\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	SPTAN1 RNF213 HSPA12B DYNC1H1 EHD2	1.58e-05	200	70	5	5c092b2ecc081b5d04476c56333c338cd89ab984
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Activated_Alv_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	SPTAN1 RNF213 HSPA12B DYNC1H1 EHD2	1.58e-05	200	70	5	79e51afb57ca38aacebd0298e5e727b55c0cfff9
ToppCell	Control_saline-Endothelial-Endothelial-Activated_Alv_Cap\|Control_saline / Treatment groups by lineage, cell group, cell type	RNF213 HSPA12B DYNC1H1 STAT3 EHD2	1.58e-05	200	70	5	be55cef682ba87250dad97689332c8820b3a7420
Drug	dicaprylphosphatidylcholine	MTR PCSK7 PPL	1.54e-06	8	70	3	CID000166886
Drug	Khellin [82-02-0]; Down 200; 15.4uM; HL60; HG-U133A	NEFH PIEZO1 SPTAN1 PCSK7 PKN1 NCLN BTN2A1	2.31e-06	195	70	7	2004_DN
Drug	Acenocoumarol [152-72-7]; Up 200; 11.4uM; HL60; HG-U133A	NBEAL2 SPTAN1 PCSK7 ZNF202 PKN1 AKIP1 DNAJC3	2.47e-06	197	70	7	1394_UP
Drug	TIBA	MTR PAX5 DNAH5 DYNC1H1	5.01e-06	37	70	4	CID000006948
Drug	Starch	SREBF1 ACTN1 EHD3	3.06e-05	20	70	3	ctd:D013213
Drug	Condelphine [7633-69-4]; Down 200; 8.8uM; PC3; HT_HG-U133A	BTN2A2 NBEAL2 PIEZO1 PCSK7 ZNF202 PPL	3.13e-05	196	70	6	6357_DN
Drug	Troleandomycin [2751-09-9]; Down 200; 5uM; PC3; HT_HG-U133A	CRYBA2 WDR33 NBEAL2 EHD1 PPL EHD3	3.13e-05	196	70	6	3985_DN
Drug	Berberine chloride [633-65-8]; Down 200; 10.8uM; MCF7; HT_HG-U133A	NBEAL2 EHD1 PRKCA CHST7 DNAJC3 BTN2A1	3.22e-05	197	70	6	6791_DN
Drug	Lidocaone hydrochloride [73-78-9]; Down 200; 14.8uM; HL60; HG-U133A	NEFH BTN2A2 PIEZO1 EHD1 ACTN1 NCLN	3.31e-05	198	70	6	1999_DN
Drug	Dexamethasone acetate [1177-87-3]; Down 200; 9.2uM; MCF7; HT_HG-U133A	CLASP1 NBEAL2 EHD1 CCDC85C PCSK7 CHST7	3.31e-05	198	70	6	6271_DN
Drug	chlorpromazine hydrochloride; Down 200; 1uM; MCF7; HT_HG-U133A_EA	DDX31 PIEZO1 EHD1 PCSK7 DNAJC3 EHD3	3.40e-05	199	70	6	1055_DN
Drug	haloperidol; Down 200; 10uM; MCF7; HT_HG-U133A	STARD13 DDX31 EHD1 CCDC85C MAP7 PPL	3.40e-05	199	70	6	6963_DN
Drug	Diphemanil methylsulfate [62-97-5]; Down 200; 10.2uM; HL60; HG-U133A	NEFH STARD8 EHD1 PCSK7 PRKCA G6PD	3.50e-05	200	70	6	1994_DN
Drug	Haloperidol [52-86-8]; Down 200; 10.6uM; HL60; HG-U133A	STARD8 EHD1 PCSK7 PRKCA TARS2 BTN2A1	3.50e-05	200	70	6	2039_DN
Drug	sodium taurodihydrofusidate	PCSK7 PPL	5.57e-05	4	70	2	CID003035005
Disease	phenylketonuria (biomarker_via_orthology)	NEFH G6PD	1.48e-05	3	66	2	DOID:9281 (biomarker_via_orthology)
Disease	gonadal dysgenesis (implicated_via_orthology)	STARD13 STARD8	2.95e-05	4	66	2	DOID:14447 (implicated_via_orthology)
Disease	post-traumatic stress disorder	BPTF BTN2A2 PRKCA ACTN1 BTN2A1	9.11e-05	202	66	5	EFO_0001358
Disease	Gastrointestinal Diseases	MTR CHD8	3.21e-04	12	66	2	C0017178
Disease	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	PAX5 STAT3	3.21e-04	12	66	2	C0023485
Disease	Functional Gastrointestinal Disorders	MTR CHD8	3.21e-04	12	66	2	C0559031
Disease	Cholera Infantum	MTR CHD8	3.21e-04	12	66	2	C1565321
Disease	prostate carcinoma (is_implicated_in)	PRKCA STAT3	3.78e-04	13	66	2	DOID:10286 (is_implicated_in)
Disease	response to irinotecan	TRIL SYNE3	5.08e-04	15	66	2	EFO_0004829
Disease	Autism Spectrum Disorders	ROGDI CHD8 UNC80	9.26e-04	85	66	3	C1510586
Disease	kidney disease (biomarker_via_orthology)	SREBF1 G6PD	1.01e-03	21	66	2	DOID:557 (biomarker_via_orthology)
Disease	triglyceride measurement, intermediate density lipoprotein measurement	BPTF PCSK7 STAT3	2.00e-03	111	66	3	EFO_0004530, EFO_0008595
Disease	endometrial carcinoma	BPTF PKN1 EIF2AK4	2.10e-03	113	66	3	EFO_1001512

Protein segments in the cluster

Peptide	Gene	Start	Entry
ELREIEWRCVIIDEA	CHD8	936	Q9HCK8
WLLNEIRRLERLDHL	ACTN1	381	P12814
DTVRLWRLFREILDG	EIF2AK4	821	Q9P2K8
RWFAERVDLIILLFD	EHD2	176	Q9NZN4
LEVLERAKRRAVDWH	AKIP1	26	Q9NQ31
LWDEEDFQGRRCRLL	CRYBA2	16	P53672
EELELWEIRAFAERV	BPTF	2016	Q12830
LEVCVWDAELRELRA	DNAJC3	181	Q13217
AQRLEERERIIREIW	EVA1A	121	Q9H8M9
HFVRSDELREAWRIF	G6PD	451	P11413
DVLAWEHERFAIRRL	NCLN	366	Q969V3
AWEIRDRLLAERVCD	PAX5	111	Q02548
LELEAWERGRAVDLR	GDF5	311	P43026
LAAREIVWLEREERA	MAP7	81	Q14244
RTIRGFEALIEREWL	MTMR9	356	Q96QG7
LWLRRLTREDDLETC	LRFN1	261	Q9P244
EELLRWSKEELARRL	CCDC85C	21	A6NKD9
CLAEFKRDLEWVERL	EBNA1BP2	56	Q99848
VWSAVDIRDRQRLLE	PCSK7	616	Q16549
RLWSLERELDDLKRL	PPL	1611	O60437
RVRLFTDWRERFCAI	FUT7	306	Q11130
ELVWLRRLAREDDLE	LRFN3	256	Q9BTN0
RLRWLVFDEADRILD	DDX31	381	Q9H8H2
LLVRDGRRWCTDVFE	HSPA12B	561	Q96MM6
IELDAVWEDIRERFV	PRPF40A	761	O75400
TLQSEEWFRVRLDRL	NEFH	286	P12036
LWVEERFTAHIARVR	ENPP3	826	O14638
RRWKLGDDIDLIVRC	EIF3D	361	O15371
VEALVTEAWRRLERF	FASTKD1	136	Q53R41
TEAWRRLERFDIKLL	FASTKD1	141	Q53R41
EELRWRRTFLHAVDV	BTN2A1	316	Q7KYR7
RVVEHWIEVARECRI	RALGDS	461	Q12967
LIRIWAHEALRLFQD	DYNC1H1	2821	Q14204
ELRWRRTFLHAADVV	BTN2A2	316	Q8WVV5
EWFAERVDRIILLFD	EHD1	176	Q9H4M9
REHLLAQWELEVFER	MAP3K11	441	Q16584
LEFEVLFHRAWLRQI	DNAH5	671	Q8TE73
EWISHIEECVRRQLR	PLEKHF1	121	Q96S99
EAWREEAELRDHRRI	TARS2	291	Q9BW92
RHELSREAFLREVWQ	VARS2	206	Q5ST30
ERAVLEEEFRWLLHD	ROGDI	11	Q9GZN7
VLNRVLRERHLWDED	STARD13	966	Q9Y3M8
LILWEEERAERRLTA	TRMT44	341	Q8IYL2
LVGDCRRVIWRDLEA	SYT15	256	Q9BQS2
DRIQILERLDSDWCR	SH3D19	686	Q5HYK7
RELAESWRALRLLEE	SYNE3	731	Q6ZMZ3
VREHAFFRRIDWEKL	PRKCA	591	P17252
LCLDLWGTERREERR	RIMBP3	1386	Q9UFD9
ELRLFLAQRLRWLCD	NBEAL2	466	Q6ZNJ1
AFAEELHERVRRELW	MTR	1136	Q99707
LELERARELELAVFW	PKN1	421	Q16512
ILEEEDDLWVRIRHR	STXBP3	281	O00186
EWFAERVDRIILLFD	EHD3	176	Q9NZN3
VLHRVLRERALWDED	STARD8	876	Q92502
WLRRDEEAAERLCPL	SREBF1	886	P36956
EVICEAWLRDLLFAR	CHST7	346	Q9NS84
RRRCFEFLDLLLQEW	CLASP1	461	Q7Z460
IRLWELERDRLRFTE	GTF2H4	391	Q92759
VEEALDWRREELLLL	RNF213	1136	Q63HN8
LLDWDRVRVFDREIA	TOP3B	256	O95985
DDLWTRRRSERIFLH	TNRC18	1991	O15417
LALWDFLDFIVRTRI	UNC80	2831	Q8N2C7
IARIVARCLWEESRL	STAT3	101	P40763
SEERAALLELWELRR	SPTAN1	446	Q13813
EAFWGLEALRELRLE	TRIL	271	Q7L0X0
RERERLHEEWLLREQ	ZRSR2P1	71	Q15695
RDTRARLVLWDCLIL	PIEZO1	1206	Q92508
RLWDLRTLRCERHFE	WDR27	736	A2RRH5
VRIWDFLRCHEERIL	WDR33	226	Q9C0J8
REALIRLRELCHQWL	ZNF202	61	O95125
LLRIAWARIILDEAH	TTF2	726	Q9UNY4