Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionsuperoxide-generating NADPH oxidase activator activity

NCF1 NCF1C NCF1B

3.71e-0610643GO:0016176
GeneOntologyMolecularFunctionsuperoxide-generating NAD(P)H oxidase activity

NCF1 NCF1C NCF1B

6.77e-0612643GO:0016175
GeneOntologyMolecularFunctionbenzoate-CoA ligase activity

ACSM2A ACSM2B

3.03e-053642GO:0018858
GeneOntologyMolecularFunctionoxidoreductase activity, acting on NAD(P)H, oxygen as acceptor

NCF1 NCF1C NCF1B

3.44e-0520643GO:0050664
GeneOntologyMolecularFunctiondecanoate-CoA ligase activity

ACSM2A ACSM2B

6.04e-054642GO:0102391
GeneOntologyMolecularFunctionphosphatidylinositol-3,4-bisphosphate binding

NCF1 NCF1C NCF1B

1.91e-0435643GO:0043325
GeneOntologyMolecularFunctionfatty-acyl-CoA synthase activity

ACSM2A ACSM2B

2.80e-048642GO:0004321
GeneOntologyMolecularFunctionmedium-chain fatty acid-CoA ligase activity

ACSM2A ACSM2B

5.46e-0411642GO:0031956
GeneOntologyMolecularFunctionhistone H3K36 methyltransferase activity

PRDM9 SETMAR

7.71e-0413642GO:0046975
GeneOntologyMolecularFunctionGTPase inhibitor activity

SLIT2 RTKN

7.71e-0413642GO:0005095
GeneOntologyMolecularFunctionacyltransferase activity, transferring groups other than amino-acyl groups

LPCAT3 SRCAP ACSM2A MOGAT3 ACSM2B

9.92e-04238645GO:0016747
GeneOntologyMolecularFunctiontransition metal ion binding

ADCY10 TRIM49 CPA6 USP5 PRDM9 SETMAR MGAT1 TIMP2 POLE TRIM49C ALOXE3

1.29e-0311896411GO:0046914
GeneOntologyMolecularFunctionhistone binding

SUPT6H RSF1 PARP9 SSRP1 SRCAP

1.60e-03265645GO:0042393
GeneOntologyBiologicalProcessneutrophil-mediated killing of gram-positive bacterium

NCF1 NCF1C NCF1B

2.84e-075643GO:0070946
GeneOntologyBiologicalProcessNADP catabolic process

NCF1 NCF1C NCF1B

9.88e-077643GO:0006742
GeneOntologyBiologicalProcessneutrophil-mediated killing of fungus

NCF1 NCF1C NCF1B

9.88e-077643GO:0070947
GeneOntologyBiologicalProcessnegative regulation of muscle contraction

ADCY10 NCF1 NCF1C NCF1B

4.11e-0635644GO:0045932
GeneOntologyBiologicalProcessregulation of respiratory burst involved in inflammatory response

NCF1 NCF1C NCF1B

4.62e-0611643GO:0060264
GeneOntologyBiologicalProcessreactive oxygen species biosynthetic process

ADCY10 CCN6 NCF1 NCF1C NCF1B

4.93e-0680645GO:1903409
GeneOntologyBiologicalProcessrespiratory burst involved in inflammatory response

NCF1 NCF1C NCF1B

7.97e-0613643GO:0002536
GeneOntologyBiologicalProcessneutrophil-mediated killing of bacterium

NCF1 NCF1C NCF1B

1.55e-0516643GO:0070944
GeneOntologyBiologicalProcessresponse to yeast

NCF1 NCF1C NCF1B

2.25e-0518643GO:0001878
GeneOntologyBiologicalProcessneutrophil-mediated killing of symbiont cell

NCF1 NCF1C NCF1B

2.66e-0519643GO:0070943
GeneOntologyBiologicalProcessrespiratory burst involved in defense response

NCF1 NCF1C NCF1B

3.13e-0520643GO:0002679
GeneOntologyBiologicalProcessneutrophil mediated cytotoxicity

NCF1 NCF1C NCF1B

3.64e-0521643GO:0070942
GeneOntologyBiologicalProcessnegative regulation of smooth muscle contraction

NCF1 NCF1C NCF1B

4.21e-0522643GO:0045986
GeneOntologyBiologicalProcesshydrogen peroxide biosynthetic process

NCF1 NCF1C NCF1B

4.21e-0522643GO:0050665
GeneOntologyBiologicalProcessregulation of respiratory burst

NCF1 NCF1C NCF1B

4.83e-0523643GO:0060263
GeneOntologyBiologicalProcesskilling by host of symbiont cells

NCF1 NCF1C NCF1B

2.22e-0438643GO:0051873
GeneOntologyBiologicalProcessleukotriene metabolic process

NCF1 NCF1C NCF1B

2.79e-0441643GO:0006691
GeneOntologyBiologicalProcessrespiratory burst

NCF1 NCF1C NCF1B

3.22e-0443643GO:0045730
GeneOntologyBiologicalProcessneutrophil mediated immunity

NCF1 NCF1C NCF1B

4.46e-0448643GO:0002446
GeneOntologyBiologicalProcesssuperoxide anion generation

NCF1 NCF1C NCF1B

5.03e-0450643GO:0042554
GeneOntologyBiologicalProcessnucleobase-containing small molecule metabolic process

ADCY10 MGAT1 NCF1 PFAS PARP9 ACSM2A NCF1C NCF1B ACSM2B

5.72e-04767649GO:0055086
GeneOntologyCellularComponentNADPH oxidase complex

NCF1 NCF1C NCF1B

2.16e-0518643GO:0043020
GeneOntologyCellularComponentSWI/SNF superfamily-type complex

ARID2 RSF1 SRCAP TRRAP

2.15e-0496644GO:0070603
GeneOntologyCellularComponentATPase complex

ARID2 RSF1 SRCAP TRRAP

6.60e-04129644GO:1904949
GeneOntologyCellularComponentSwr1 complex

SRCAP TRRAP

7.04e-0413642GO:0000812
MousePhenoincreased angiotensin I-converting enzyme activity

NCF1 NCF1C NCF1B

1.14e-066553MP:0003184
MousePhenoabnormal angiotensin I-converting enzyme activity

NCF1 NCF1C NCF1B

1.14e-066553MP:0013254
MousePhenoliver abscess

NCF1 NCF1C NCF1B

1.99e-067553MP:0003332
MousePhenoabnormal circulating renin level

NCF1 SUCNR1 NCF1C NCF1B

4.73e-0629554MP:0003349
MousePhenoimpaired granulocyte bactericidal activity

NCF1 NCF1C NCF1B

6.78e-0610553MP:0005074
MousePhenodecreased susceptibility to Orthomyxoviridae infection

NCF1 NCF1C NCF1B

4.51e-0518553MP:0020947
MousePhenoabnormal Purkinje cell dendrite morphology

SLIT2 GRID2 STK38L MICU1

7.77e-0558554MP:0008572
MousePhenodecreased vasoconstriction

NCF1 NCF1C NCF1B

8.42e-0522553MP:0003026
MousePhenosingle kidney

TIMP2 NCF1 NCF1C NCF1B

9.48e-0561554MP:0003604
MousePhenoincreased circulating renin level

NCF1 NCF1C NCF1B

9.65e-0523553MP:0003352
MousePhenooxidative stress

NCF1 QDPR NCF1C NCF1B MICU1

3.19e-04152555MP:0003674
MousePhenoimpaired smooth muscle contractility

NCF1 NCF1C NCF1B

3.45e-0435553MP:0000740
MousePhenogranulomatous inflammation

NCF1 NCF1C NCF1B

3.75e-0436553MP:0002500
MousePhenoabnormal redox activity

NCF1 QDPR NCF1C NCF1B MICU1

5.78e-04173555MP:0003186
DomainAMP-bd_C

ACSM2A ACSM2B

1.38e-0317612IPR025110
DomainAMP-binding_C

ACSM2A ACSM2B

1.38e-0317612PF13193
DomainRNaseH-like_dom

SETMAR SUPT6H POLE

1.49e-0369613IPR012337
DomainCTCK_1

CCN6 SLIT2

1.55e-0318612PS01185
DomainPLAT

ALOXE3 PNLIPRP3

2.12e-0321612PS50095
Domain-

ALOXE3 PNLIPRP3

2.12e-03216122.60.60.20
DomainPLAT

ALOXE3 PNLIPRP3

2.12e-0321612PF01477
DomainPLAT/LH2_dom

ALOXE3 PNLIPRP3

2.12e-0321612IPR001024
DomainCT

CCN6 SLIT2

2.32e-0322612SM00041
DomainCys_knot_C

CCN6 SLIT2

3.00e-0325612IPR006207
DomainCTCK_2

CCN6 SLIT2

3.00e-0325612PS01225
DomainAMP-binding_CS

ACSM2A ACSM2B

3.24e-0326612IPR020845
DomainAMP_BINDING

ACSM2A ACSM2B

3.76e-0328612PS00455
DomainAMP-binding

ACSM2A ACSM2B

4.30e-0330612PF00501
DomainAMP-dep_Synth/Lig

ACSM2A ACSM2B

4.30e-0330612IPR000873
DomainConA-like_dom

TRIM49 SLIT2 CLGN TRIM49C

5.70e-03219614IPR013320
DomainSET

PRDM9 SETMAR

7.93e-0341612PF00856
PathwayREACTOME_CROSS_PRESENTATION_OF_PARTICULATE_EXOGENOUS_ANTIGENS_PHAGOSOMES

NCF1 NCF1C NCF1B

3.92e-069523MM14524
PathwayREACTOME_RHO_GTPASES_ACTIVATE_NADPH_OXIDASES

NCF1 NCF1C NCF1B

1.03e-0425523MM15269
PathwayREACTOME_CONJUGATION_OF_SALICYLATE_WITH_GLYCINE

ACSM2A ACSM2B

1.98e-046522MM14693
PathwayBIOCARTA_FMLP_PATHWAY

NCF1 NCF1C NCF1B

2.61e-0434523MM1399
PathwayREACTOME_AMINO_ACID_CONJUGATION

ACSM2A ACSM2B

2.77e-047522MM14598
PathwayREACTOME_DETOXIFICATION_OF_REACTIVE_OXYGEN_SPECIES

NCF1 NCF1C NCF1B

2.85e-0435523MM14944
PathwayREACTOME_ROS_AND_RNS_PRODUCTION_IN_PHAGOCYTES

NCF1 NCF1C NCF1B

3.65e-0438523MM14519
PathwayREACTOME_AMINO_ACID_CONJUGATION

ACSM2A ACSM2B

4.73e-049522M26968
PathwayWP_MICROGLIA_PATHOGEN_PHAGOCYTOSIS_PATHWAY

NCF1 NCF1C NCF1B

6.43e-0446523MM15837
Pubmed

Distinct histopathological phenotypes of severe alcoholic hepatitis suggest different mechanisms driving liver injury and failure.

NCF1 LYZ NCF1C NCF1B

1.04e-11464435838051
Pubmed

Cancer cells induce metastasis-supporting neutrophil extracellular DNA traps.

NCF1 LYZ NCF1C NCF1B

1.04e-11464427798263
Pubmed

Riboflavin (vitamin B2 ) deficiency impairs NADPH oxidase 2 (Nox2) priming and defense against Listeria monocytogenes.

NCF1 LYZ NCF1C NCF1B

5.20e-11564424272050
Pubmed

Enriched conditioning expands the regenerative ability of sensory neurons after spinal cord injury via neuronal intrinsic redox signaling.

NCF1 LYZ NCF1C NCF1B

1.56e-10664433349630
Pubmed

Phagocyte respiratory burst activates macrophage erythropoietin signalling to promote acute inflammation resolution.

NCF1 LYZ NCF1C NCF1B

1.56e-10664427397585
Pubmed

Experimental lupus is aggravated in mouse strains with impaired induction of neutrophil extracellular traps.

NCF1 LYZ NCF1C NCF1B

1.56e-10664428515366
Pubmed

Reactive oxygen species regulate axonal regeneration through the release of exosomal NADPH oxidase 2 complexes into injured axons.

NCF1 LYZ NCF1C NCF1B

3.63e-10764429434374
Pubmed

Memory CD8+ T cells mediate antibacterial immunity via CCL3 activation of TNF/ROI+ phagocytes.

NCF1 LYZ NCF1C NCF1B

7.26e-10864417698589
Pubmed

Developmental expression of NADPH phagocytic oxidase components in mouse embryos.

NCF1 LYZ NCF1C NCF1B

1.30e-09964410447107
Pubmed

Reactive oxygen species and p47phox activation are essential for the Mycobacterium tuberculosis-induced pro-inflammatory response in murine microglia.

NCF1 NCF1C NCF1B

5.94e-09364318036262
Pubmed

Transient loss of resistance to pulmonary tuberculosis in p47(phox-/-) mice.

NCF1 NCF1C NCF1B

5.94e-09364310678931
Pubmed

Colitis susceptibility in p47(phox-/-) mice is mediated by the microbiome.

NCF1 NCF1C NCF1B

5.94e-09364327044504
Pubmed

Suppression of microglial inflammatory activity by myelin phagocytosis: role of p47-PHOX-mediated generation of reactive oxygen species.

NCF1 NCF1C NCF1B

5.94e-09364317167081
Pubmed

Mice lacking NCF1 exhibit reduced growth of implanted melanoma and carcinoma tumors.

NCF1 NCF1C NCF1B

5.94e-09364324358335
Pubmed

Molecular characterization of the mouse p47-phox (Ncf1) gene and comparative analysis of the mouse p47-phox (Ncf1) gene to the human NCF1 gene.

NCF1 NCF1C NCF1B

5.94e-09364310891396
Pubmed

P47phox-/- mice are compromised in expansion and activation of CD8+ T cells and susceptible to Trypanosoma cruzi infection.

NCF1 NCF1C NCF1B

5.94e-09364325474113
Pubmed

NADPH oxidase in bone marrow-derived cells mediates pulmonary ischemia-reperfusion injury.

NCF1 NCF1C NCF1B

5.94e-09364318787174
Pubmed

NAD(P)H oxidase subunit p47phox is elevated, and p47phox knockout prevents diaphragm contractile dysfunction in heart failure.

NCF1 NCF1C NCF1B

5.94e-09364326209274
Pubmed

Deficient production of reactive oxygen species leads to severe chronic DSS-induced colitis in Ncf1/p47phox-mutant mice.

NCF1 NCF1C NCF1B

5.94e-09364324873968
Pubmed

p47(phox) is required for afferent arteriolar contractile responses to angiotensin II and perfusion pressure in mice.

NCF1 NCF1C NCF1B

5.94e-09364322184329
Pubmed

NADPH oxidase-derived free radicals are key oxidants in alcohol-induced liver disease.

NCF1 NCF1C NCF1B

5.94e-09364311018074
Pubmed

Natural Loss-of-Function Mutations in Qa2 and NCF1 Cause the Spread of Mannan-Induced Psoriasis.

NCF1 NCF1C NCF1B

5.94e-09364333545139
Pubmed

Small-molecule screen identifies reactive oxygen species as key regulators of neutrophil chemotaxis.

NCF1 NCF1C NCF1B

5.94e-09364320142487
Pubmed

Enhanced host defense after gene transfer in the murine p47phox-deficient model of chronic granulomatous disease.

NCF1 NCF1C NCF1B

5.94e-0936439116268
Pubmed

Mice producing less reactive oxygen species are relatively resistant to collagen glycopeptide vaccination against arthritis.

NCF1 NCF1C NCF1B

5.94e-09364320686129
Pubmed

Angiotensin II induced catabolic effect and muscle atrophy are redox dependent.

NCF1 NCF1C NCF1B

5.94e-09364321570954
Pubmed

p47(phox) contributes to albuminuria and kidney fibrosis in mice.

NCF1 NCF1C NCF1B

5.94e-09364325565313
Pubmed

Knockout of neutrophil cytosolic factor 1 ameliorates neuroinflammation and motor deficit after traumatic brain injury.

NCF1 NCF1C NCF1B

5.94e-09364339357591
Pubmed

Oscillatory shear stress stimulates endothelial production of O2- from p47phox-dependent NAD(P)H oxidases, leading to monocyte adhesion.

NCF1 NCF1C NCF1B

5.94e-09364312958309
Pubmed

Genetic demonstration of p47phox-dependent superoxide anion production in murine vascular smooth muscle cells.

NCF1 NCF1C NCF1B

5.94e-09364311435342
Pubmed

Neutrophil Cytosolic Factor 1 in Dendritic Cells Promotes Autoreactive CD8+ T Cell Activation via Cross-Presentation in Type 1 Diabetes.

NCF1 NCF1C NCF1B

5.94e-09364331118934
Pubmed

Female mice lacking p47phox have altered adipose tissue gene expression and are protected against high fat-induced obesity.

NCF1 NCF1C NCF1B

5.94e-09364323482812
Pubmed

Virulence comparisons of Aspergillus nidulans mutants are confounded by the inflammatory response of p47phox-/- mice.

NCF1 NCF1C NCF1B

5.94e-09364316041040
Pubmed

The p47(phox-/-) mouse model of chronic granulomatous disease has normal granuloma formation and cytokine responses to Mycobacterium avium and Schistosoma mansoni eggs.

NCF1 NCF1C NCF1B

5.94e-09364310085000
Pubmed

Oxidants from nicotinamide adenine dinucleotide phosphate oxidase are involved in triggering cell proliferation in the liver due to peroxisome proliferators.

NCF1 NCF1C NCF1B

5.94e-09364310987289
Pubmed

Methamphetamine alters occludin expression via NADPH oxidase-induced oxidative insult and intact caveolae.

NCF1 NCF1C NCF1B

5.94e-09364321435178
Pubmed

Intermittent hypoxia has organ-specific effects on oxidative stress.

NCF1 NCF1C NCF1B

5.94e-09364318703411
Pubmed

Mycobacterial infection induces higher interleukin-1β and dysregulated lung inflammation in mice with defective leukocyte NADPH oxidase.

NCF1 NCF1C NCF1B

5.94e-09364329228045
Pubmed

Mycobacteria-induced Gr-1+ subsets from distinct myeloid lineages have opposite effects on T cell expansion.

NCF1 NCF1C NCF1B

5.94e-09364317307863
Pubmed

Generation of reactive oxygen species (ROS) is a key factor for stimulation of macrophage proliferation by ceramide 1-phosphate.

NCF1 NCF1C NCF1B

5.94e-09364322155727
Pubmed

Ncf1 affects osteoclast formation but is not critical for postmenopausal bone loss.

NCF1 NCF1C NCF1B

5.94e-09364327829407
Pubmed

Mechanism of endoplasmic reticulum stress-induced vascular endothelial dysfunction.

NCF1 NCF1C NCF1B

5.94e-09364324576409
Pubmed

The presence of p47phox in liver parenchymal cells is a key mediator in the pathogenesis of alcoholic liver steatosis.

NCF1 NCF1C NCF1B

5.94e-09364322376231
Pubmed

Leishmania amazonensis amastigotes trigger neutrophil activation but resist neutrophil microbicidal mechanisms.

NCF1 NCF1C NCF1B

5.94e-09364323918780
Pubmed

NADPH oxidase NOX2 mediates TLR2/6-dependent release of GM-CSF from endothelial cells.

NCF1 NCF1C NCF1B

5.94e-09364328274989
Pubmed

The p47phox deficiency significantly attenuates the pathogenicity of Chlamydia muridarum in the mouse oviduct but not uterine tissues.

NCF1 NCF1C NCF1B

5.94e-09364326645958
Pubmed

Role of p47(phox) in vascular oxidative stress and hypertension caused by angiotensin II.

NCF1 NCF1C NCF1B

5.94e-09364312364355
Pubmed

NADPH oxidase promotes neutrophil extracellular trap formation in pulmonary aspergillosis.

NCF1 NCF1C NCF1B

5.94e-09364324549323
Pubmed

NOX2-Deficient Neutrophils Facilitate Joint Inflammation Through Higher Pro-Inflammatory and Weakened Immune Checkpoint Activities.

NCF1 NCF1C NCF1B

5.94e-09364334557202
Pubmed

Reactive Oxygen Species Regulate Both Priming and Established Arthritis, but with Different Mechanisms.

NCF1 NCF1C NCF1B

5.94e-09364328467721
Pubmed

P47(phox)-deficient NADPH oxidase defect in neutrophils of diabetic mouse strains, C57BL/6J-m db/db and db/+.

NCF1 NCF1C NCF1B

5.94e-09364310670582
Pubmed

NADPH oxidase deficiency regulates Th lineage commitment and modulates autoimmunity.

NCF1 NCF1C NCF1B

5.94e-09364320881184
Pubmed

Direct Comparison of a Natural Loss-Of-Function Single Nucleotide Polymorphism with a Targeted Deletion in the Ncf1 Gene Reveals Different Phenotypes.

NCF1 NCF1C NCF1B

5.94e-09364326528554
Pubmed

The role of reactive oxygen species in immunopathogenesis of rheumatoid arthritis.

NCF1 NCF1C NCF1B

5.94e-09364319052348
Pubmed

Effect of early particulate air pollution exposure on obesity in mice: role of p47phox.

NCF1 NCF1C NCF1B

5.94e-09364320864666
Pubmed

Reactive oxygen species delay control of lymphocytic choriomeningitis virus.

NCF1 NCF1C NCF1B

5.94e-09364323328631
Pubmed

p47phox-Dependent Oxidant Signalling through ASK1, MKK3/6 and MAPKs in Angiotensin II-Induced Cardiac Hypertrophy and Apoptosis.

NCF1 NCF1C NCF1B

5.94e-09364334572995
Pubmed

Acid aspiration-induced lung inflammation and injury are exacerbated in NADPH oxidase-deficient mice.

NCF1 NCF1C NCF1B

5.94e-09364317114280
Pubmed

Participation of mitochondrial respiratory complex III in neutrophil activation and lung injury.

NCF1 NCF1C NCF1B

5.94e-09364319168575
Pubmed

B-cell epitope spreading and inflammation in a mouse model of arthritis is associated with a deficiency in reactive oxygen species production.

NCF1 NCF1C NCF1B

5.94e-09364325989352
Pubmed

NADPH oxidase is the primary source of superoxide induced by NMDA receptor activation.

NCF1 NCF1C NCF1B

5.94e-09364319503084
Pubmed

Hypoglycemic neuronal death is triggered by glucose reperfusion and activation of neuronal NADPH oxidase.

NCF1 NCF1C NCF1B

5.94e-09364317404617
Pubmed

Critical role of the NAD(P)H oxidase subunit p47phox for left ventricular remodeling/dysfunction and survival after myocardial infarction.

NCF1 NCF1C NCF1B

5.94e-09364317332431
Pubmed

Lpp of Escherichia coli K1 inhibits host ROS production to counteract neutrophil-mediated elimination.

NCF1 NCF1C NCF1B

5.94e-09364336592568
Pubmed

Genetic requirement of p47phox for superoxide production by murine microglia.

NCF1 NCF1C NCF1B

5.94e-09364311156938
Pubmed

Tumour-elicited neutrophils engage mitochondrial metabolism to circumvent nutrient limitations and maintain immune suppression.

NCF1 NCF1C NCF1B

5.94e-09364330504842
Pubmed

Genomic structure of the human p47-phox (NCF1) gene.

NCF1 NCF1C NCF1B

5.94e-09364310772875
Pubmed

A Feed-Forward Mechanism Involving the NOX Complex and RyR-Mediated Ca2+ Release During Axonal Specification.

NCF1 NCF1C NCF1B

5.94e-09364327798190
Pubmed

Endothelium-dependent coronary vasodilatation requires NADPH oxidase-derived reactive oxygen species.

NCF1 NCF1C NCF1B

5.94e-09364320702812
Pubmed

Direct interaction of HIV gp120 with neuronal CXCR4 and CCR5 receptors induces cofilin-actin rod pathology via a cellular prion protein- and NOX-dependent mechanism.

NCF1 NCF1C NCF1B

5.94e-09364333705493
Pubmed

Inhibition of NADPH oxidase by apocynin attenuates progression of atherosclerosis.

NCF1 NCF1C NCF1B

5.94e-09364323965970
Pubmed

Macrophage-derived reactive oxygen species protects against autoimmune priming with a defined polymeric adjuvant.

NCF1 NCF1C NCF1B

5.94e-09364326455429
Pubmed

Superoxide generation from Kupffer cells contributes to hepatocarcinogenesis: studies on NADPH oxidase knockout mice.

NCF1 NCF1C NCF1B

5.94e-09364315513930
Pubmed

Conditional haploinsufficiency of NCF1 (encoding p47(phox)), a signaling gene with a heterozygous phenotype potentially subject to natural selection.

NCF1 NCF1C NCF1B

5.94e-09364315626477
Pubmed

Phosphoinositide 3-kinase regulates the phosphorylation of NADPH oxidase component p47(phox) by controlling cPKC/PKCdelta but not Akt.

NCF1 NCF1C NCF1B

5.94e-09364315033459
Pubmed

NCF1 gene and pseudogene pattern: association with parasitic infection and autoimmunity.

NCF1 NCF1C NCF1B

5.94e-09364319077231
Pubmed

Neutrophil-derived ROS contribute to oxidative DNA damage induction by quartz particles.

NCF1 NCF1C NCF1B

5.94e-09364320828610
Pubmed

p47phox Phox homology domain regulates plasma membrane but not phagosome neutrophil NADPH oxidase activation.

NCF1 NCF1C NCF1B

5.94e-09364320817944
Pubmed

Reduction of NADPH-oxidase activity ameliorates the cardiovascular phenotype in a mouse model of Williams-Beuren Syndrome.

NCF1 NCF1C NCF1B

5.94e-09364322319452
Pubmed

Early determinants of H2O2-induced endothelial dysfunction.

NCF1 NCF1C NCF1B

5.94e-09364316895801
Pubmed

Role and cellular source of nicotinamide adenine dinucleotide phosphate oxidase in hepatic fibrosis.

NCF1 NCF1C NCF1B

5.94e-09364320690191
Pubmed

Endosomal acidification and activation of NADPH oxidase isoforms are upstream events in hyperosmolarity-induced hepatocyte apoptosis.

NCF1 NCF1C NCF1B

5.94e-09364316772302
Pubmed

Aging increases vulnerability to stress-induced depression via upregulation of NADPH oxidase in mice.

NCF1 NCF1C NCF1B

5.94e-09364332504071
Pubmed

Effect of p47phox gene deletion on ROS production and oxygen sensing in mouse carotid body chemoreceptor cells.

NCF1 NCF1C NCF1B

5.94e-09364316280459
Pubmed

Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease.

NCF1 NCF1C NCF1B

5.94e-09364318185592
Pubmed

NCF1-dependent production of ROS protects against lupus by regulating plasmacytoid dendritic cell development and functions.

NCF1 NCF1C NCF1B

5.94e-09364336853827
Pubmed

Prolonged production of reactive oxygen species in response to B cell receptor stimulation promotes B cell activation and proliferation.

NCF1 NCF1C NCF1B

5.94e-09364323024271
Pubmed

Ncf1 (p47phox) is essential for direct regulatory T cell mediated suppression of CD4+ effector T cells.

NCF1 NCF1C NCF1B

5.94e-09364321253614
Pubmed

Synergistic innate and adaptive immune response to combination immunotherapy with anti-tumor antigen antibodies and extended serum half-life IL-2.

NCF1 NCF1C NCF1B

5.94e-09364325873172
Pubmed

Enhanced autoimmunity, arthritis, and encephalomyelitis in mice with a reduced oxidative burst due to a mutation in the Ncf1 gene.

NCF1 NCF1C NCF1B

5.94e-09364315310853
Pubmed

Exogenous PP2A inhibitor exacerbates the progression of nonalcoholic fatty liver disease via NOX2-dependent activation of miR21.

NCF1 NCF1C NCF1B

5.94e-09364331393787
Pubmed

Vascular effects following homozygous disruption of p47(phox) : An essential component of NADPH oxidase.

NCF1 NCF1C NCF1B

5.94e-09364310725280
Pubmed

Ncf1 Governs Immune Niches in the Lung to Mediate Pulmonary Inflammation in Mice.

NCF1 NCF1C NCF1B

5.94e-09364334970267
Pubmed

Germ-free mice deficient of reactive oxygen species have increased arthritis susceptibility.

NCF1 NCF1C NCF1B

5.94e-09364325689796
Pubmed

Opposing roles of p47phox in basal versus angiotensin II-stimulated alterations in vascular O2- production, vascular tone, and mitogen-activated protein kinase activation.

NCF1 NCF1C NCF1B

5.94e-09364314993144
Pubmed

Inhibition of NADPH oxidase promotes alternative and anti-inflammatory microglial activation during neuroinflammation.

NCF1 NCF1C NCF1B

5.94e-09364322050439
Pubmed

The vascular NADPH oxidase subunit p47phox is involved in redox-mediated gene expression.

NCF1 NCF1C NCF1B

5.94e-09364312031896
Pubmed

NAD(P)H oxidase-derived superoxide mediates hypercholesterolemia-induced leukocyte-endothelial cell adhesion.

NCF1 NCF1C NCF1B

5.94e-09364311249873
Pubmed

Ncf1 (p47phox) polymorphism determines oxidative burst and the severity of arthritis in rats and mice.

NCF1 NCF1C NCF1B

5.94e-09364315936744
Pubmed

NADPH oxidase modulates myocardial Akt, ERK1/2 activation, and angiogenesis after hypoxia-reoxygenation.

NCF1 NCF1C NCF1B

5.94e-09364317220182
Cytoband7q11.23

NCF1 NCF1C NCF1B

3.47e-04976437q11.23
Cytoband3q25.1

SUCNR1 EIF2A

9.82e-04336423q25.1
Cytoband16p12.3

ACSM2A ACSM2B

1.04e-033464216p12.3
CytobandEnsembl 112 genes in cytogenetic band chr11q14

TRIM49 RSF1 TRIM49C

1.38e-03156643chr11q14
Cytoband12p13

USP5 LPCAT3

3.65e-036464212p13
CytobandEnsembl 112 genes in cytogenetic band chr12p11

PPFIBP1 STK38L

6.34e-0385642chr12p11
CytobandEnsembl 112 genes in cytogenetic band chr7q11

NCF1 NCF1C NCF1B

6.50e-03271643chr7q11
GeneFamilyAcyl-CoA synthetase family

ACSM2A ACSM2B

1.81e-032644240
CoexpressionZENG_GU_ICB_CONTROL_METAGENE_25_PRECICTIVE_ICB_RESPONSE

TRIM49 NCF1 TRIM49C LYZ NCF1C NCF1B

1.85e-05225646MM17079
CoexpressionGAVIN_PDE3B_TARGETS

NCF1 NCF1C NCF1B

3.07e-0525643MM726
CoexpressionWOO_LIVER_CANCER_RECURRENCE_DN

EPHX2 CSAD ACY1 QDPR

4.03e-0578644M9911
CoexpressionHOWARD_DENDRITIC_CELL_INACT_MONOV_INFLUENZA_A_INDONESIA_05_2005_H5N1_AGE_18_49YO_1DY_UP

NCF1 PARP9 SUCNR1 NCF1C NCF1B

4.41e-05159645M40998
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

EPHX2 ACY1 ACSM2A MOGAT3 ACSM2B

6.62e-0618364585446581999cd66b171c4f69b7eb8b0bbbaa8617
ToppCell5'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial-LEC5_(CLDN11+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ELAPOR2 RAMP3 NALCN PPFIBP1 ACSM2B

6.97e-06185645241ea1e178fffef9e7df971de739e794332d5173
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_hypoxia/MES-D|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

MGAT1 NCF1 NCF1C NCF1B ARPC3

8.14e-06191645a143af67fc3270439f390edec599d2e3d29a107f
ToppCelldistal-Hematologic-Interstitial_Macrophage-3|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

NCF1 SUCNR1 LYZ NCF1C NCF1B

9.23e-06196645e4f40274df940e0996c555082f2bb4f99e5b0881
ToppCellcontrol-CD163+_Monocytes_(Sample_ID1_d7)|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

TIMP2 SCARB2 NCF1 PARP9 LYZ

9.93e-06199645933201d32eda12a89660bdbae9114a95cc428a38
ToppCell10x3'2.3-week_14-16-Myeloid_neutrophil-granulo-neutrophil-neutrophil|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

SELL MGAT1 NCF1 LYZ ARPC3

9.93e-061996450dde17381b8a95bfddb4d1052b13d33f37b05d13
ToppCellSevere-Myeloid-Macrophages|Severe / Condition, Lineage, Cell class and cell subclass

MGAT1 TIMP2 SCARB2 NCF1 LYZ

1.02e-05200645ee1d80fa5d4609f9a6b10c33950e888f509a063c
ToppCellsevere-immature_Neutrophil|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

CLTCL1 POLE NCF1 SUCNR1 LYZ

1.02e-05200645a9b87accdaa6956116ab82427e1330e8f007ef94
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_hypoxia/MES-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

MGAT1 NCF1 SRCAP NCF1C NCF1B

1.02e-05200645851c57187db8bc91a393655bca5f13e787a723d4
ToppCellCOVID-19-kidney-Technical/muscle_(PCT)|COVID-19 / Disease (COVID-19 only), tissue and cell type

XKR7 GRID2 ACSM2A ACSM2B

4.80e-05139644a1945b07f177cde40e7eea03a19236ce76165857
ToppCellBLOOD--(3)_MNP-(3)_Classical_Mono-1|(3)_MNP / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

SELL TIMP2 NCF1 LYZ

5.22e-05142644395f80e99be4a0ef07fb9d65c74399e7e67c9a8d
ToppCellfacs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ADCY10 ELAPOR2 POLE ACSM2B

8.70e-05162644bf886e22ff2a20353499004b53f25fb9e6574896
ToppCell3'_v3-GI_small-bowel-Lymphocytic_T_CD8-Tem/emra_CD8|GI_small-bowel / Manually curated celltypes from each tissue

SLIT2 FAM131C SUCNR1 LYZ

8.91e-051636441a8c79903ed416f286ebe8a9922233affbc55d82
ToppCell343B-Myeloid-Macrophage-SPP1+_Macrophage|343B / Donor, Lineage, Cell class and subclass (all cells)

XKR7 TIMP2 SUCNR1 LYZ

9.12e-05164644057ca87847373eff7fe97dd9f4358509e66ca4c3
ToppCellHippocampus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Cbln1-Excitatory_Neuron.Slc17a7.Reln_(Medial_entorrhinal_cortexm,_Reln+/Cbln1+)-|Hippocampus / BrainAtlas - Mouse McCarroll V32

ADCY10 CPA6 XKR7

9.31e-05616435e855b5462f42b7a1d0bbd518cc11072342ce0cc
ToppCellHippocampus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Cbln1-Excitatory_Neuron.Slc17a7.Reln_(Medial_entorrhinal_cortexm,_Reln+/Cbln1+)|Hippocampus / BrainAtlas - Mouse McCarroll V32

ADCY10 CPA6 XKR7

9.31e-05616432fc13475581431f82e0b5ef42e18cd29c9787666
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Granulocytic|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SELL PRDM9 NCF1 SLC24A3

1.02e-041696442e15a9317da4017757d184f7cc91bd66b072ac51
ToppCell3'-Airway_Nasal-Immune_Myeloid-Myeloid_monocytic-classical_monocyte-Classical_monocytes|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SELL NCF1 LYZ ARPC3

1.05e-0417064446a81d505de845cc59f80594fce338f7fdb9250f
ToppCell3'-Airway_Nasal-Immune_Myeloid-Myeloid_monocytic-classical_monocyte|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SELL NCF1 LYZ ARPC3

1.05e-041706441a9a0487c35cf3fd5806d1f0f0e91ef0e0b9cd0a
ToppCell3'-Airway_Nasal-Immune_Myeloid-Myeloid_monocytic|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SELL NCF1 LYZ ARPC3

1.05e-04170644830646815410c47e9bca8c9bae75dfc45c9c9b33
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage-Monocyte-derived_macrophage-Monocyte-derived_macrophage_L.1.2.5.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MGAT1 NCF1 LYZ JMJD1C

1.07e-041716445e93c76ee60f9d0590ebb140812653a5e1369417
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L5-6_SST_ISOC1|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SLIT2 TIMP2 FAM131C GRID2

1.20e-04176644d09e28606e2a6ed1f660898316765ca215085c18
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ACY1 ACSM2A MOGAT3 ACSM2B

1.39e-04183644d73cac83cde82665f110baad7cf28db75f9ffe52
ToppCellControl-Endothelial-Endothelial-Activated_Alv_Cap|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

RAMP3 PARP9 QDPR LYZ

1.39e-04183644e81c142770f44fd902b0631bc360c5b5339d4c75
ToppCellfacs-Trachea-24m-Epithelial-glandular_epithelial|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

EPHX2 ELAPOR2 SV2A FAM131C

1.42e-0418464461caaa31975e05c9a6512079c791fed5a9e2d39f
ToppCellfacs-Trachea-24m-Epithelial-glandular_epithelial-lung_secretory_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

EPHX2 ELAPOR2 SV2A FAM131C

1.42e-0418464403da0f0f89f1ca5a3ccca1e22972f3129464e68e
ToppCellfacs-Trachea-24m-Epithelial-glandular_epithelial-lung_secretory_cell-mucous|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

EPHX2 ELAPOR2 SV2A FAM131C

1.42e-041846449ed2a65a4ca0ebbbb89ace61027522f93369843d
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L4_RORB_CACNG5|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CPA6 SLIT2 SLC24A3 GRID2

1.42e-04184644658f2e522055e88c92bc482a845c40f8f5f1a8e3
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L5-6_SST_ISOC1|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SLIT2 TIMP2 GRID2 PNLIPRP3

1.45e-04185644ae53aa2ecfe418a5dbd7d963a995bc06dab94f56
ToppCell3'-Child09-12-SmallIntestine-Endothelial-lymphatic_endothelial-LEC3_(ADGRG3+)|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NALCN PPFIBP1 ACSM2A ACSM2B

1.45e-041856449de1db2ce9e44956b1214daf6e1e161334679c88
ToppCell3'-Child09-12-SmallIntestine-Endothelial-lymphatic_endothelial|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NALCN PPFIBP1 ACSM2A ACSM2B

1.45e-0418564418f5d9438c76e37988a7d17aa2a080af6bedbfc4
ToppCellControl-B_naive-5|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)

SELL NCF1 LYZ ARPC3

1.51e-041876448c48d67435e168edb892217b3f82c74f2dcedc14
ToppCellCOVID-19_Convalescent-Classical_Monocyte|COVID-19_Convalescent / Disease condition and Cell class

SELL NCF1 LYZ

1.53e-047264373db21be480920fc936f3a965495f5cf004e350a
ToppCellControl-B_naive-5|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

SELL NCF1 LYZ ARPC3

1.57e-04189644d39e112417a850f6e7b33315eab636fa90448301
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SLIT2 NALCN SLC24A3 STK38L

1.61e-041906442e88e366d377d74deb53a4ea870973ce5c6532e8
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SLIT2 NALCN SLC24A3 STK38L

1.61e-041906440028f886c789ba238c031eae5d96acaed4af8c25
ToppCell3'-Pediatric_IBD-SmallIntestine-Endothelial-lymphatic_endothelial-LEC3_(ADGRG3+)|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TIMP2 PPFIBP1 ACSM2A ACSM2B

1.64e-04191644361b123c8289015206d5e706ab2c615d9a724179
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_I-D|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SELL NCF1 NCF1C NCF1B

1.64e-041916447d00796459f4ff0ab7f06a8379b2d34e76b078b2
ToppCellILEUM-inflamed-(7)_Endothelial_cell-(7)_Lymphatics|(7)_Endothelial_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

TIMP2 PPFIBP1 ACSM2A ACSM2B

1.67e-04192644d43caf42ec744e895137f31ef65a990e250669d2
ToppCellrenal_cortex_nuclei|World / Celltypes from Cells and Nuclei per compartment and clinical group

SLIT2 ACSM2A JMJD1C ACSM2B

1.67e-04192644e8cc4d08fcfceeab75a02558817e4ccd7dbafe3a
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SLIT2 TIMP2 FAM131C SLC24A3

1.71e-0419364453bcd50892c379b2a571751f6eb1062436339fe7
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Myeloid_monocytic-classical_monocyte-Classical_monocytes-Classical_monocytes_L.1.2.0.2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SELL NCF1 LYZ ARPC3

1.71e-041936443d254bc85187745ba41d86646bd4cc681a71d13e
ToppCell3'-Parenchyma_lung-Immune_Myeloid-Myeloid_monocytic-classical_monocyte-Classical_monocytes-Classical_monocytes_L.1.2.4.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SELL MGAT1 LYZ ARPC3

1.71e-04193644891c0d4119a1c090b8230d00f9f69997850cab8c
ToppCellSmart-seq2-lymph_node_(Smart-seq2)-lymphocytic-B_lymphocytic-B_cell|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

NCF1 NCF1C NCF1B JMJD1C

1.74e-04194644ff661419b697aef51a53fdeac8d37d870d65f491
ToppCellMild/Remission-B_activate-7|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)

SELL NCF1 PARP9 JMJD1C

1.74e-0419464401c97543972159a9468272da06e7e611e2c21fae
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_hypoxia/MES-E|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

MGAT1 ALOXE3 SUCNR1 NCF1C

1.77e-04195644d53585715c7f5827c4f5a6db11cb31857ee9d4f0
ToppCellBronchial-NucSeq-Immune_Lymphocytic-B-B_cell-B_mature|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SELL NCF1 INPP5F ACSM2A

1.77e-041956443311a1bf4ed94820b45047d44fc14b14ac72e6fb
ToppCellcontrol-CD163+_Monocytes_(Sample_ID1_d7)|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

TIMP2 NCF1 PARP9 LYZ

1.77e-0419564419413dc6aa0010686cdfa0c750ef0a7a76caf308
ToppCelldistal-2-Endothelial-Lymphatic|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

PPFIBP1 RTKN ACSM2A ACSM2B

1.77e-041956448e0f67a67af3bc0b16f48a621f74540f136383b7
ToppCellmyeloid-Monocyte-CD14+_Monocyte|myeloid / Lineage, cell class and subclass

SELL TIMP2 NCF1 LYZ

1.77e-0419564415ba9c5f6ecb6ae2c603e6b036eb92b00b46f13f
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_hypoxia/MES-C|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

NCF1 NCF1C NCF1B ARPC3

1.77e-04195644de47651c84da62f273535fc80115f0154746699d
ToppCelldistal-Endothelial-Lymphatic-2|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

PPFIBP1 RTKN ACSM2A ACSM2B

1.77e-04195644f45c1349932ee7eb419cced8a4fdedae3610953f
ToppCellmetastatic_Brain-Myeloid_cells-Monocytes|Myeloid_cells / Location, Cell class and cell subclass

SELL NCF1 LYZ JMJD1C

1.81e-04196644d1a2768a1d0e5928fbd9debb7dcd7436134e09f6
ToppCelldistal-Endothelial-Lymphatic|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

PPFIBP1 RTKN ACSM2A ACSM2B

1.81e-041966443e8a20e1d163dcbd3bbd99fe179d54af02298af0
ToppCellURO-Myeloid-CD14_Mono|URO / Disease, Lineage and Cell Type

SELL TIMP2 NCF1 LYZ

1.84e-0419764445c16125fa32e50304fdd45a7cb457488bd50ee3
ToppCellsevere_COVID-19-Classical_Monocyte|World / disease group, cell group and cell class (v2)

SELL TIMP2 NCF1 LYZ

1.84e-04197644cdffd49db7374d223ded46d636cd4be12d464ea4
ToppCellTracheal-10x5prime-Stromal-Peri/Epineurial_|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

CPA6 CCN6 NALCN TIMP2

1.84e-041976442cb1f557ce1400398975de94638126b4522567f3
ToppCell390C-Myeloid-Monocyte-CD14+_Monocyte|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

SELL MGAT1 LYZ ARPC3

1.84e-04197644cd941c5ef76897047bd8508d98510c4ff164d223
ToppCellInfluenza_Severe-Classical_Monocyte|World / Disease group and Cell class

SELL TIMP2 NCF1 LYZ

1.84e-04197644e9a01f0fbbeaf6b23bce4603f62053c003848da4
ToppCellT_cells-Treg_cells|T_cells / Immune cells in Kidney/Urine in Lupus Nephritis

SELL EPHX2 SV2A INPP5F

1.84e-04197644ec9398ae3577f61d6b1e6aba50ef4261aaaa7610
ToppCellproximal-Hematologic-B_cell|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

SELL NCF1 NCF1C NCF1B

1.84e-04197644735b5026d28cd3677947ae8e462f6fd640cf9c9b
ToppCellT_cells-Treg_cells|World / Immune cells in Kidney/Urine in Lupus Nephritis

SELL EPHX2 SV2A INPP5F

1.84e-04197644de5448fcdf4e433fc167496413abe5d0c8a5c6d8
ToppCellproximal-Hematologic-B_cell-3|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

SELL NCF1 NCF1C NCF1B

1.84e-0419764408b3f2e3933242b9fa93998cfce3d094a3db833e
ToppCellproximal-3-Hematologic-B_cell|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

SELL NCF1 NCF1C NCF1B

1.84e-0419764481ba0eb2222e83b4ba2db3228dc04c390c2dbc63
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_hypoxia/MES-Z|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

MGAT1 NCF1 LYZ ARPC3

1.84e-04197644367aaf277c56962c96ddb4de06949fb33fc6170b
ToppCellcontrol-Myeloid|control / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

SELL TIMP2 LYZ NCF1C

1.88e-04198644abf08cde20c1843d54ba008c1db5a6ab376c761e
ToppCell10x3'2.3-week_14-16-Myeloid_neutrophil-granulo-neutrophil-myelocyte|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

SELL MGAT1 LYZ ARPC3

1.88e-04198644c7c5865395992131d0766a03c9c63bad9196b02f
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Myeloid_monocytic-classical_monocyte-Classical_monocytes-Classical_monocytes_L.1.2.0.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SELL NCF1 LYZ ARPC3

1.88e-04198644d5c816fb894f55acbbab188e6262668acc422fb9
ToppCellproximal-Hematologic-Classical_Monocyte-3|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

SELL NCF1 LYZ NCF1C

1.88e-041986446a7ca6eef6b74aa7fc3aec84e9ffd0beedaa589b
ToppCellLPS_IL1RA_TNF-Hematopoietic_Myeloid|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

SELL NCF1 LYZ ARPC3

1.88e-04198644c4a004f211f72f28aacbb512c6e075cbd049be53
ToppCellmild-Myeloid|mild / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

SELL TIMP2 LYZ NCF1C

1.88e-04198644908746384e10c6b833bb3bc124045d7b0bfd73b5
ToppCell10x3'2.3-week_12-13-Myeloid_neutrophil-granulo-neutrophil-myelocyte|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

SELL NCF1 LYZ ARPC3

1.88e-04198644c65103828a4755fcf3c0776c60d8ada1f0ad5278
ToppCell390C-Myeloid-Monocyte|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

MGAT1 TIMP2 LYZ ARPC3

1.88e-0419864436e49a4860b37d674511120b9e0366efa1e08480
ToppCellsevere-Myeloid|severe / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

SELL TIMP2 LYZ NCF1C

1.88e-04198644d19902a6353445f9875dec59933b7553f5145b8b
ToppCellproximal-3-Hematologic-Classical_Monocyte|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

SELL NCF1 LYZ NCF1C

1.88e-041986446c6a63b8ec03b7a8f46b70bf13261fab56355f92
ToppCell3'-Parenchyma_lung-Immune_Myeloid-Myeloid_monocytic-classical_monocyte-Classical_monocytes-Classical_monocytes_L.1.2.0.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SELL NCF1 LYZ ARPC3

1.88e-041986446d547122b8c4ddbdd0d3dae3bce4a125740d5457
ToppCellproximal-Hematologic-Classical_Monocyte|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

SELL NCF1 LYZ NCF1C

1.88e-0419864498bd2b3e03ab659ce163d5773660ce008e4cc2ca
ToppCellInfluenza_Severe-Classical_Monocyte|Influenza_Severe / Disease group and Cell class

SELL TIMP2 NCF1 LYZ

1.92e-04199644077ace6e0faedb8c701fcb227427204678867237
ToppCell10x3'2.3-week_12-13-Myeloid_neutrophil-granulo-neutrophil-neutrophil|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

SELL NCF1 LYZ ARPC3

1.92e-041996447cbd98dd10c91584dee04593910031e90c1340b8
ToppCellBAL-Mild-Myeloid|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

TIMP2 SCARB2 NCF1 LYZ

1.92e-041996440f0fcc6fb980167cfa9aa404b845441fb95a08f4
ToppCellLPS_IL1RA-Hematopoietic_Myeloid|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

SELL NCF1 LYZ ARPC3

1.92e-041996440e696f13c9bd135fbb31368d6dca29897d6a1a25
ToppCellBAL-Mild-Myeloid|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TIMP2 SCARB2 NCF1 LYZ

1.92e-041996443662ed5d929ab64293e65f33dabcefc3458a08e5
ToppCellMild-Myeloid-Macrophages|Mild / Condition, Lineage, Cell class and cell subclass

TIMP2 SCARB2 NCF1 LYZ

1.92e-04199644d8a00e6aecc4bfd1f868f1ee54bcfa820401efaf
ToppCellMild_COVID-19-Myeloid|Mild_COVID-19 / Disease group,lineage and cell class (2021.01.30)

TIMP2 SCARB2 NCF1 LYZ

1.92e-04199644c0a9f5629db5beff7c07c9d111a7707e062d746f
ToppCellBAL-Control-cDC_0|Control / Compartment, Disease Groups and Clusters

TIMP2 SCARB2 NCF1 LYZ

1.92e-041996444518ffa51ead9da1ddf07bf048b18602e50f0f84
ToppCellLPS_only-Hematopoietic_Myeloid|LPS_only / Treatment groups by lineage, cell group, cell type

SELL NCF1 LYZ ARPC3

1.92e-0419964420523dee39a4c5f6423259920f108127b47525c4
ToppCellMild-Myeloid|Mild / Condition, Lineage, Cell class and cell subclass

TIMP2 SCARB2 NCF1 LYZ

1.92e-041996440678e50ffda664fb76681a1ee9021deab73bf850
ToppCellMild-Myeloid-Macrophages-FCN1+SPP1+|Mild / Condition, Lineage, Cell class and cell subclass

TIMP2 SCARB2 NCF1 LYZ

1.92e-041996442cbaef86af870a228cb46895dd765ea8894c83c5
ToppCellsevere_influenza-Classical_Monocyte|severe_influenza / disease group, cell group and cell class (v2)

SELL TIMP2 NCF1 LYZ

1.92e-04199644899d9fa9e3d97e876da27674de89c33bff1affe9
ToppCell390C-Myeloid-Monocyte-CD16+_Monocyte|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

MGAT1 TIMP2 LYZ ARPC3

1.92e-041996441a691dbf3da26f5450bde428a7c886dbc4834c81
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-myeloid-myeloid_macrophage-macrophage|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

MGAT1 TIMP2 SCARB2 LYZ

1.95e-04200644bc56d6d6d32405685e9bd553ebdbe48b8fbe6902
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW26|fetalBrain_Zhong_nature / Sample Type, Dataset, Time_group, and Cell type.

RAMP3 TIMP2 PPFIBP1 SLC24A3

1.95e-0420064461d7dd0a78942b069c3f5e75044368dc00e6e8e6
ToppCellSevere-Myeloid|Severe / Condition, Lineage, Cell class and cell subclass

MGAT1 SCARB2 NCF1 LYZ

1.95e-0420064477ae7b037226d479b37077d20a3cc150da251900
ToppCellCOVID-19-COVID-19_Severe-Myeloid-immature_Neutrophil|COVID-19_Severe / Disease, condition lineage and cell class

CLTCL1 POLE NCF1 LYZ

1.95e-04200644cbe667eda1af222467df8bfa157aa22df488f133
ToppCellBAL-Severe-Myeloid|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

MGAT1 TIMP2 SCARB2 LYZ

1.95e-04200644bb246c630b2fde1633b28838a5f087fdfb4bc4a5
ToppCell3'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage-Monocyte-derived_macrophage-Monocyte-derived_macrophage_L.1.0.1.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MGAT1 TIMP2 LYZ ARPC3

1.95e-0420064435bbd3fc96c4f249bd79c4c5ad8ee6eb6df32c33
ToppCellSepsis-URO-Myeloid-CD14+_Monocyte|URO / Disease, condition lineage and cell class

SELL TIMP2 NCF1 LYZ

1.95e-04200644209976dbbfc1edbeb3ea128cd0453ec9572f54cb
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_hypoxia/MES-F|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

MGAT1 NCF1 SRCAP NCF1C

1.95e-042006445f1de1f9305e1784c12d526f6c8bdd7d56229f9b
ToppCellInfluenza-Influenza_Severe-Myeloid|Influenza_Severe / Disease, condition lineage and cell class

SELL TIMP2 NCF1 LYZ

1.95e-042006442bf931ec2c6165698ba600b151fd30d8dd921d95
ToppCellNeuronal-Inhibitory-iB-iB_3(PVALB-SST)-NPM1P10|Neuronal / cells hierarchy compared to all cells using T-Statistic

SLIT2 TIMP2 GRID2 PNLIPRP3

1.95e-042006447b3284bf0000e14f5a51e4422231e5639a184579
Drugtesaglitazar

SELL ADCY10 EPHX2 SLIT2 NALCN LPCAT3 CSAD SLC24A3 GRID2 LYZ

9.56e-075026210ctd:C501413
Diseasechronic granulomatous disease (implicated_via_orthology)

NCF1 NCF1C NCF1B

8.81e-085623DOID:3265 (implicated_via_orthology)
Diseaserheumatoid arthritis (implicated_via_orthology)

NCF1 NCF1C NCF1B

1.92e-0612623DOID:7148 (implicated_via_orthology)
DiseaseX-21319 measurement

ACSM2A ACSM2B

4.34e-062622EFO_0800807
DiseaseX-11478 measurement

ACSM2A ACSM2B

1.30e-053622EFO_0021242
Disease3-hydroxyhexanoate measurement

ACSM2A ACSM2B

4.33e-055622EFO_0800378
Diseasegamma-enolase measurement

USP5 JMJD1C

6.48e-056622EFO_0021845
Diseaseindoleacetoylcarnitine measurement

ACSM2A ACSM2B

6.48e-056622EFO_0800106
DiseaseREM sleep behavior disorder

SCARB2 INPP5F

6.48e-056622EFO_0007462
Diseasematrix metalloproteinase measurement

DYNC2H1 SLC24A3

3.34e-0413622EFO_0004744
Diseasepsychosis

NALCN SLC24A3

3.89e-0414622EFO_0005407
DiseaseX-24309 measurement

EPHX2 DNAJC13

8.05e-0420622EFO_0800872
Diseasephosphatidylinositol measurement

RAMP3 SUPT6H SCARB2

1.07e-0395623EFO_0010230
Diseaseurinary uromodulin measurement

LYZ ACSM2A ACSM2B

1.10e-0396623EFO_0005663
DiseaseAdenoid Cystic Carcinoma

SLC24A3 SRCAP JMJD1C

1.24e-03100623C0010606
Diseasemigraine disorder, pulse pressure measurement

DYNC2H1 SLC24A3

1.37e-0326622EFO_0005763, MONDO_0005277
Diseaseuridine measurement

SLIT2 NALCN

2.07e-0332622EFO_0010546

Protein segments in the cluster

PeptideGeneStartEntry
WVNGKGKELMWNFRE

ACSM2A

71

Q08AH3
NFMCLWQSCKKWFQT

ARID2

1631

Q68CP9
NILEKCWLNMNKESW

ADCY10

1546

Q96PN6
FKNCDLMWKQSIWTS

QDPR

101

P09417
NRNWKVKWCDEGASM

CPA6

271

Q8N4T0
DMMGKVDVWKWCNLS

RAMP3

46

O60896
WMEWDKQGCTGKLQR

PARP9

201

Q8IXQ6
WKTDGKWQRDMCNVL

PNLIPRP3

96

Q17RR3
ISLANWMCLAKWESG

LYZ

41

P61626
WCVSAWNDNGKEQMV

MGAT1

236

P26572
DMPFAKWTKEQVCNW

PPFIBP1

641

Q86W92
KWTKEQVCNWLMEQG

PPFIBP1

646

Q86W92
GSWKKLDDMQNIFWC

ALOXE3

241

Q9BYJ1
SSNWKLFKECWKQGQ

JMJD1C

2176

Q15652
EKWGWIMFECGLENL

KIAA1109

1886

Q2LD37
LMQAMWKCAQETAWD

MICU1

456

Q9BPX6
CFIAMLETWWNKRKG

GRID2

846

O43424
VEKSESGWWFCQMKA

NCF1

186

P14598
AKWDACANMKVWLFE

LPCAT3

311

Q6P1A2
NIFKLWGWTMLCCDF

SELL

16

P14151
ANCQRKMAWQWRGEF

POLE

661

Q07864
KWWNVLPGNMKTSCF

ELAPOR2

441

A8MWY0
NCNKPRWEKWFMVTF

SLC24A3

466

Q9HC58
VVEKSESGWWFCQMK

NCF1B

186

A6NI72
VVEKSESGWWFCQMK

NCF1C

161

A8MVU1
GSWQHWCQLTFKKLM

MOGAT3

246

Q86VF5
DGKDKSWANWMRYVN

PRDM9

306

Q9NQV7
NEGSFKWKMLWITSC

CCN6

321

O95389
KKCQVLWMEGWSNSS

DYNC2H1

2801

Q8NCM8
FWNQGLTWKVLFCSM

CLCN6

271

P51797
YRNMERNWKWACKSL

EPHX2

466

P34913
PSKWWTCFVKRQFMN

ARPC3

156

O15145
SQEMKCILHWFANWS

C14orf119

36

Q9NWQ9
KDKQMDFCWDPWQRC

FAM131C

46

Q96AQ9
DCLKLWLMWKAQGDQ

CSAD

361

Q9Y600
ELWTKGMLNAKTRCW

DNAJC13

996

O75165
LWCPTTENMDKDGKW

ELSPBP1

151

Q96BH3
KSFIQKKMQNWCPSW

EIF2A

121

Q9BY44
KKMQNWCPSWSEDET

EIF2A

126

Q9BY44
QEFNSTWAWEMEKKG

RSF1

96

Q96T23
MKWCWVDEAGVICKQ

INPP5F

436

Q9Y2H2
LWQLFFDMSQWKQCC

RTKN

411

Q9BST9
WNWAFGVCNMYRKEK

TRIM49

351

P0CI25
MQTGYNKLCDWWSLG

STK38L

296

Q9Y2H1
ANERTVQWWFKKFCK

SETMAR

381

Q53H47
AEWWKQAGLNLKMME

SHOC1

361

Q5VXU9
SLDWWITDKCNMING

SCARB2

236

Q14108
NWEMELKRWCPSFKI

SRCAP

681

Q6ZRS2
QEKRGEHLSWLCMFW

SV2A

286

Q7L0J3
ELMEKDLCVKGWNWG

SSRP1

96

Q08945
WVNGKGKELMWNFRE

ACSM2B

71

Q68CK6
NPWWAAFSRVCKDMN

ACY1

321

Q03154
ADGWRWKIMIANANK

CLGN

441

O14967
KGNNWWAQSVELCKK

CLTCL1

1516

P53675
NNVCAKKMDWTGSIW

CLCC1

251

Q96S66
AIDWGKMAEQWLQEK

SUPT6H

1671

Q7KZ85
MGQCRNWKWGLESFD

ZSCAN5DP

1

P0CG00
FWVIQGETDFCMSKW

XKR7

341

Q5GH72
VTDLRDVKCSGNWMW

PFAS

756

O15067
DVKCSGNWMWAAKLP

PFAS

761

O15067
WNWAFGVCNMYRKEK

TRIM49C

351

P0CI26
ECLWMDWVTEKNING

TIMP2

171

P16035
LYCDCNMQWLSDWVK

SLIT2

861

O94813
MLGIMAWNATCKNWL

SUCNR1

1

Q9BXA5
EMACQGHKWALKALW

TTLL4

826

Q14679
QNWEAMGNHFWIKQC

TRRAP

2481

Q9Y4A5
QEEDMWAGLWQKRCK

TRRAP

2756

Q9Y4A5
GWKCSKCDMRENLWL

USP5

196

P45974
MTDAASCGSEVKKWW

NALCN

1706

Q8IZF0