Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	growth factor activity	ANGPTL3 LEP GKN1	5.59e-04	173	19	3	GO:0008083
GeneOntologyMolecularFunction	palmitoyltransferase activity	ZDHHC12 HHAT	5.60e-04	37	19	2	GO:0016409
GeneOntologyMolecularFunction	acyltransferase activity, transferring groups other than amino-acyl groups	CERS5 ZDHHC12 HHAT	1.41e-03	238	19	3	GO:0016747
GeneOntologyBiologicalProcess	lipoprotein metabolic process	PIGB LEP ZDHHC12 HHAT	8.83e-06	147	19	4	GO:0042157
GeneOntologyBiologicalProcess	regulation of glucagon secretion	PASK LEP	3.60e-05	10	19	2	GO:0070092
GeneOntologyBiologicalProcess	glucagon secretion	PASK LEP	3.60e-05	10	19	2	GO:0070091
GeneOntologyBiologicalProcess	protein lipidation	PIGB ZDHHC12 HHAT	1.04e-04	101	19	3	GO:0006497
GeneOntologyBiologicalProcess	lipoprotein biosynthetic process	PIGB ZDHHC12 HHAT	1.20e-04	106	19	3	GO:0042158
GeneOntologyBiologicalProcess	energy reserve metabolic process	PASK LEP ADRB1	1.49e-04	114	19	3	GO:0006112
GeneOntologyBiologicalProcess	glycerol metabolic process	ANGPTL3 LEP	1.84e-04	22	19	2	GO:0006071
GeneOntologyBiologicalProcess	carbohydrate metabolic process	ANGPTL3 PASK LEP ADRB1 GLB1L2	2.39e-04	646	19	5	GO:0005975
GeneOntologyBiologicalProcess	alditol metabolic process	ANGPTL3 LEP	2.58e-04	26	19	2	GO:0019400
GeneOntologyBiologicalProcess	energy homeostasis	PASK LEP ADRB1	2.98e-04	144	19	3	GO:0097009
GeneOntologyBiologicalProcess	protein palmitoylation	ZDHHC12 HHAT	4.17e-04	33	19	2	GO:0018345
GeneOntologyBiologicalProcess	cholesterol metabolic process	ANGPTL3 LEP DHCR7	4.28e-04	163	19	3	GO:0008203
GeneOntologyBiologicalProcess	secondary alcohol metabolic process	ANGPTL3 LEP DHCR7	5.35e-04	176	19	3	GO:1902652
GeneOntologyBiologicalProcess	sterol metabolic process	ANGPTL3 LEP DHCR7	5.44e-04	177	19	3	GO:0016125
GeneOntologyBiologicalProcess	response to dietary excess	LEP ADRB1	8.48e-04	47	19	2	GO:0002021
GeneOntologyBiologicalProcess	peptidyl-cysteine modification	ZDHHC12 HHAT	9.59e-04	50	19	2	GO:0018198
Domain	GSG-1	GSG1L2 GSG1L	2.94e-06	3	19	2	IPR012478
Domain	GSG-1	GSG1L2 GSG1L	2.94e-06	3	19	2	PF07803
Domain	-	GLB1L2 EPHA8	2.47e-03	73	19	2	2.60.120.260
Domain	Galactose-bd-like	GLB1L2 EPHA8	4.05e-03	94	19	2	IPR008979
Pubmed	Leptin and insulin down-regulate angiopoietin-like protein 3, a plasma triglyceride-increasing factor.	ANGPTL3 LEP	2.83e-07	2	19	2	15336575
Pubmed	The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.	ANGPTL3 MAMDC4 ADAMTSL4 GSG1L GLB1L2 PRG3 GKN1	5.35e-07	985	19	7	12975309
Pubmed	Role of angiopoietin-like 3 (ANGPTL3) in regulating plasma level of low-density lipoprotein cholesterol.	ANGPTL3 LEP	1.70e-06	4	19	2	29183623
Pubmed	Induction of glucose uptake in skeletal muscle by central leptin is mediated by muscle β2-adrenergic receptor but not by AMPK.	LEP ADRB1	1.70e-06	4	19	2	29123236
Pubmed	PAQR4 regulates adipocyte function and systemic metabolic health by mediating ceramide levels.	CERS5 LEP	2.82e-06	5	19	2	38961186
Pubmed	Dense Intra-adipose Sympathetic Arborizations Are Essential for Cold-Induced Beiging of Mouse White Adipose Tissue.	LEP ADRB1	5.93e-06	7	19	2	28918935
Pubmed	The rheumatoid arthritis drug auranofin lowers leptin levels and exerts antidiabetic effects in obese mice.	LEP ADRB1	5.93e-06	7	19	2	36243005
Pubmed	Sphingolipid subtypes differentially control proinsulin processing and systemic glucose homeostasis.	CERS5 LEP	7.90e-06	8	19	2	36543979
Pubmed	Three-dimensional volume fluorescence-imaging of vascular plasticity in adipose tissues.	LEP ADRB1	7.90e-06	8	19	2	29914852
Pubmed	A candidate gene study of obstructive sleep apnea in European Americans and African Americans.	LEP ADRB1	3.69e-04	52	19	2	20538960
Pubmed	A multivariate analysis of 59 candidate genes in personality traits: the temperament and character inventory.	LEP ADRB1	4.59e-04	58	19	2	11140838
Drug	BRL 37344	LEP ADRB1	1.84e-05	8	19	2	ctd:C057368
Drug	3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate	LEP ADRB1	2.96e-05	10	19	2	ctd:C097869
Disease	Hypercholesterolemia	ANGPTL3 LEP	2.87e-04	39	19	2	C0020443
Disease	Metastatic melanoma	PASK EPHA8	5.51e-04	54	19	2	C0278883
Disease	Autistic Disorder	PASK LEP DHCR7	5.97e-04	261	19	3	C0004352
Disease	cystic fibrosis (is_marker_for)	LEP ADRB1	7.26e-04	62	19	2	DOID:1485 (is_marker_for)
Disease	chronic obstructive pulmonary disease (is_implicated_in)	LEP ADRB1	7.49e-04	63	19	2	DOID:3083 (is_implicated_in)
Disease	Hypermetropia	SSBP3 HHAT	1.99e-03	103	19	2	HP_0000540
Disease	hypertension (is_implicated_in)	LEP ADRB1	2.72e-03	121	19	2	DOID:10763 (is_implicated_in)
Disease	alkaline phosphatase measurement	SSBP3 GSG1L EPHA8 GKN1	3.57e-03	1015	19	4	EFO_0004533

Protein segments in the cluster

Peptide	Gene	Start	Entry
GWSHLAWPGLGGYSW	MAMDC4	981	Q6UXC1
WGRWEYGSFFCELWT	ADRB1	121	P08588
TWRWYTGPWGECSSE	ADAMTSL4	911	Q6UY14
PHSWDYGWSFCLAWG	GSG1L	211	Q6UXU4
HFNCPEGYSGGWWWH	ANGPTL3	391	Q9Y5C1
HFGWYLGWGDCVWLP	DHCR7	301	Q9UBM7
CYGIRFLWSSPWFWD	CERS5	156	Q8N5B7
WDYGWSYCLAWGSFA	GSG1L2	201	A8MUP6
PCYGSEWGLWWRSQD	PASK	611	Q96RG2
MHWGTLCGFLWLWPY	LEP	1	P41159
SYWHGGYDYLWCWAA	HHAT	376	Q5VTY9
CWTDGSHWNFAYWSP	PRG3	176	Q9Y2Y8
GWDSWNSIWDYGNGF	GKN1	56	Q9NS71
DRFTGYWWCPTASWE	DPP9	251	Q86TI2
YWWCPTASWEGSEGL	DPP9	256	Q86TI2
HGDWGWLTYPAHGWD	EPHA8	41	P29322
MEYWTGWFDSWGGPH	GLB1L2	276	Q8IW92
LQNWGTFYGSHPWHW	PIGB	296	Q92521
PGFLHSWWCVFWDLY	SSBP3	56	Q9BWW4
HFFCGWPSGSWETLW	ZDHHC12	241	Q96GR4