Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity	CHSY1 CHSY3	2.71e-05	4	43	2	GO:0050510
GeneOntologyMolecularFunction	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity	CHSY1 CHSY3	6.76e-05	6	43	2	GO:0047238
Domain	Chond_GalNAc	CHSY1 CHSY3	1.31e-04	8	41	2	IPR008428
Domain	CHGN	CHSY1 CHSY3	1.31e-04	8	41	2	PF05679
Pathway	KEGG_MEDICUS_REFERENCE_CHONDROITIN_SULFATE_BIOSYNTHESIS	CHSY1 CHSY3	1.14e-04	8	29	2	M47920
Pubmed	Sensory Nerve Maintains Intervertebral Disc Extracellular Matrix Homeostasis Via CGRP/CHSY1 Axis.	CHSY1 CHSY3 NTRK1	4.72e-07	12	46	3	36047655
Pubmed	Chondroitin sulfate synthase-3. Molecular cloning and characterization.	CHSY1 CHSY3	1.71e-06	2	46	2	12907687
Pubmed	NGF gene expression and secretion in white adipose tissue: regulation in 3T3-L1 adipocytes by hormones and inflammatory cytokines.	NTRK1 YLPM1	5.13e-06	3	46	2	15100092
Pubmed	Chondroitin synthase-3 regulates nucleus pulposus degeneration through actin-induced YAP signaling.	CHSY1 CHSY3	5.13e-06	3	46	2	33089528
Pubmed	Simultaneous mutation detection in 90 retinal disease genes in multiple patients using a custom-designed 300-kb retinal resequencing chip.	CDH23 PAX3 TULP1 GUCY2D	5.50e-06	87	46	4	20801516
Pubmed	Mast cells are an essential hematopoietic component for polyp development.	APC CD34	1.03e-05	4	46	2	18077429
Pubmed	Chondroitin synthases I, II, III and chondroitin sulfate glucuronyltransferase expression in colorectal cancer.	CHSY1 CHSY3	1.03e-05	4	46	2	21468578
Pubmed	Pax7, Pax3 and Mamstr genes are involved in skeletal muscle impaired regeneration of dy2J/dy2J mouse model of Lama2-CMD.	MAMSTR PAX3	1.71e-05	5	46	2	31348492
Pubmed	Limb bud colonization by somite-derived angioblasts is a crucial step for myoblast emigration.	PAX3 CD34	1.71e-05	5	46	2	22129828
Pubmed	Genetic and molecular control of folate-homocysteine metabolism in mutant mice.	APC PAX3	2.56e-05	6	46	2	12016514
Pubmed	Chondroitin sulfate N-acetylgalactosaminyltransferase-1 plays a critical role in chondroitin sulfate synthesis in cartilage.	CHSY1 CHSY3	3.58e-05	7	46	2	17145758
Pubmed	Selenoprotein N is dynamically expressed during mouse development and detected early in muscle precursors.	PAX3 NTRK1	3.58e-05	7	46	2	19698141
Pubmed	Loss of Elp1 perturbs histone H2A.Z and the Notch signaling pathway.	PAX3 NTRK1	3.58e-05	7	46	2	34590699
Pubmed	Biosynthesis of chondroitin sulphate by a Golgi-apparatus-enriched preparation from cultures of mouse mastocytoma cells.	CHSY1 CHSY3	4.77e-05	8	46	2	6781479
Pubmed	Distinct origins and genetic programs of head muscle satellite cells.	PAX3 CD34	6.12e-05	9	46	2	19531353
Pubmed	Flotillin-2 regulates epidermal growth factor receptor activation, degradation by Cbl-mediated ubiquitination, and cancer growth.	CHCHD2 ARHGAP45 CHCHD2P9 ACTBL2	7.66e-05	170	46	4	36470425
Pubmed	Endoglin is required in Pax3-derived cells for embryonic blood vessel formation.	PAX3 CD34	9.34e-05	11	46	2	26481065
Pubmed	Postnatal lethality and chondrodysplasia in mice lacking both chondroitin sulfate N-acetylgalactosaminyltransferase-1 and -2.	CHSY1 CHSY3	1.12e-04	12	46	2	29287114
Pubmed	Probing nuclear pore complex architecture with proximity-dependent biotinylation.	APC ACTBL2 GUCY2D	1.48e-04	77	46	3	24927568
Pubmed	Dorsally derived netrin 1 provides an inhibitory cue and elaborates the 'waiting period' for primary sensory axons in the developing spinal cord.	PAX3 NTRK1	1.54e-04	14	46	2	16510500
Pubmed	Loss of Elp1 disrupts trigeminal ganglion neurodevelopment in a model of familial dysautonomia.	PAX3 NTRK1	1.54e-04	14	46	2	35713404
Pubmed	LIG family receptor tyrosine kinase-associated proteins modulate growth factor signals during neural development.	LINGO1 NTRK1	1.54e-04	14	46	2	19755105
Pubmed	Familial dysautonomia model reveals Ikbkap deletion causes apoptosis of Pax3+ progenitors and peripheral neurons.	PAX3 NTRK1	1.78e-04	15	46	2	24173031
Pubmed	Modifier genes in mice and humans.	APC PAX3	2.03e-04	16	46	2	11256068
Pubmed	Zeb family members and boundary cap cells underlie developmental plasticity of sensory nociceptive neurons.	PAX3 NTRK1	2.03e-04	16	46	2	25942625
Pubmed	Modifier genes and protective alleles in humans and mice.	APC CDH23	2.03e-04	16	46	2	12787792
Pubmed	The cell proliferation antigen Ki-67 organises heterochromatin.	TICRR RIC8A QSER1 CCDC137 YLPM1	2.05e-04	410	46	5	26949251
Pubmed	The protein composition of mitotic chromosomes determined using multiclassifier combinatorial proteomics.	LRWD1 CCDC137	2.30e-04	17	46	2	20813266
Pubmed	Leber Congenital Amaurosis – RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY	TULP1 GUCY2D	2.30e-04	17	46	2	20301475
Pubmed	The paired homeodomain protein DRG11 is required for the projection of cutaneous sensory afferent fibers to the dorsal spinal cord.	PAX3 NTRK1	2.88e-04	19	46	2	11498051
Pubmed	Lbx1 specifies somatosensory association interneurons in the dorsal spinal cord.	PAX3 NTRK1	3.54e-04	21	46	2	12062038
Pubmed	The receptor guanylyl cyclase Npr2 is essential for sensory axon bifurcation within the spinal cord.	NTRK1 GUCY2D	4.25e-04	23	46	2	17954614
Pubmed	Dual role of delta-like 1 homolog (DLK1) in skeletal muscle development and adult muscle regeneration.	PAX3 CD34	4.25e-04	23	46	2	23946446
Pubmed	Leber Congenital Amaurosis / Early-Onset Severe Retinal Dystrophy Overview	TULP1 GUCY2D	5.04e-04	25	46	2	30285347
Pubmed	Adenomatous polyposis coli is required for early events in the normal growth and differentiation of the developing cerebral cortex.	APC PAX3	5.04e-04	25	46	2	19149881
Pubmed	Dynamic expression of secreted Frizzled-related protein 3 (sFRP3) in the developing mouse spinal cord and dorsal root ganglia.	PAX3 NTRK1	5.45e-04	26	46	2	23827310
Pubmed	Germline Saturation Mutagenesis Induces Skeletal Phenotypes in Mice.	CHSY1 CHSY3	5.45e-04	26	46	2	33905568
Pubmed	miR669a and miR669q prevent skeletal muscle differentiation in postnatal cardiac progenitors.	PAX3 CD34	5.45e-04	26	46	2	21708977
Pubmed	Altered gene expression in murine branchial arches following in utero exposure to retinoic acid.	PAX3 NTRK1	7.77e-04	31	46	2	7601910
Pubmed	Developmental expression of morphoregulatory genes in the mouse embryo: an analytical approach using a novel technology.	PAX3 NTRK1	7.77e-04	31	46	2	9169087
Pubmed	Specific functions for ERK/MAPK signaling during PNS development.	APC NTRK1	7.77e-04	31	46	2	21220101
Pubmed	Genome-wide association study of lung function decline in adults with and without asthma.	CDH23 KANK1	8.28e-04	32	46	2	22424883
Pubmed	Prdm12 Directs Nociceptive Sensory Neuron Development by Regulating the Expression of the NGF Receptor TrkA.	PAX3 NTRK1	8.80e-04	33	46	2	30917309
Pubmed	Expression pattern of LRR and Ig domain-containing protein (LRRIG protein) in the early mouse embryo.	LINGO1 NTRK1	9.35e-04	34	46	2	18848646
Pubmed	A cellular and molecular mosaic establishes growth and differentiation states for cranial sensory neurons.	PAX3 NTRK1	9.90e-04	35	46	2	26988119
GeneFamily	Beta 4-glycosyltransferases	CHSY1 CHSY3	2.08e-04	17	23	2	425
GeneFamily	Beta 3-glycosyltransferases	CHSY1 CHSY3	4.20e-04	24	23	2	426
ToppCell	E17.5-Mesenchymal-mesenchymal_fibroblast-mesothelial_cell_of_visceral_pleura\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	FAH KANK1 CYP2S1 LINGO1 FAM237B	1.45e-06	184	47	5	607b55022de21ddb6a2d75e085df76df7abf6624
Disease	frontotemporal dementia and/or amyotrophic lateral sclerosis-2 (implicated_via_orthology)	CHCHD2 CHCHD2P9	6.51e-06	3	44	2	DOID:0060214 (implicated_via_orthology)
Disease	Parkinson's disease 22 (implicated_via_orthology)	CHCHD2 CHCHD2P9	6.51e-06	3	44	2	DOID:0080504 (implicated_via_orthology)
Disease	spinal muscular atrophy, Jokela type (implicated_via_orthology)	CHCHD2 CHCHD2P9	6.51e-06	3	44	2	DOID:0081356 (implicated_via_orthology)
Disease	Leber congenital amaurosis (implicated_via_orthology)	PALS1 GUCY2D	1.68e-04	13	44	2	DOID:14791 (implicated_via_orthology)
Disease	S-6-hydroxywarfarin measurement	NAV2 CDH23 LINGO1 CHCHD2P9 CBLN2	2.14e-04	368	44	5	EFO_0803326
Disease	Leber congenital amaurosis	TULP1 GUCY2D	2.57e-04	16	44	2	cv:C0339527
Disease	diabetic neuropathy (biomarker_via_orthology)	BECN1 NTRK1	2.91e-04	17	44	2	DOID:9743 (biomarker_via_orthology)
Disease	eye morphology measurement	CDH23 KANK1 ARHGAP45 CBLN2	3.12e-04	218	44	4	EFO_0007858
Disease	Leber Congenital Amaurosis	TULP1 GUCY2D	4.93e-04	22	44	2	C0339527
Disease	Lewy Body Disease	BECN1 NTRK1	4.93e-04	22	44	2	C0752347
Disease	Alzheimer's disease (is_marker_for)	APC BECN1 NTRK1 AKR7A2	5.80e-04	257	44	4	DOID:10652 (is_marker_for)
Disease	Ciliopathies	CDH23 TULP1 GUCY2D	5.97e-04	110	44	3	C4277690
Disease	breast cancer (implicated_via_orthology)	APC BECN1	6.38e-04	25	44	2	DOID:1612 (implicated_via_orthology)
Disease	glaucoma (biomarker_via_orthology)	BECN1 NTRK1	8.01e-04	28	44	2	DOID:1686 (biomarker_via_orthology)
Disease	prostate cancer (implicated_via_orthology)	APC PAX3	1.11e-03	33	44	2	DOID:10283 (implicated_via_orthology)
Disease	nasal disorder	MAMSTR CYP2S1	1.25e-03	35	44	2	MONDO_0002436

Protein segments in the cluster

Peptide	Gene	Start	Entry
PGRRSQMLRMLLSPG	CCDC137	221	Q6PK04
PRVASVLGTMEMGRR	AKR7A2	36	O43488
VFPSMIGRPRHQGVM	ACTBL2	31	Q562R1
MGDQRPRDRPRSPGM	FAM47DP	1	A6NHR8
FRMVRGRRVPILMVT	HDAC11	286	Q96DB2
RGMPPLSSTMLVGIR	CDH23	1826	Q9H251
MPRGSRSRTSRMAPP	CHCHD2	1	Q9Y6H1
RMPNRTRRPGTQMVR	QSER1	1171	Q2KHR3
MGPLSARLLMQRGRP	LRWD1	1	Q9UFC0
YRVGGRTMLPIRWMP	NTRK1	681	P04629
APLPPMRLRGGRMTL	ARHGAP45	1111	Q92619
GTFRMRHMPEVPVRI	GUCY2D	961	Q02846
DGVSRRFIPPARMMS	BECN1	76	Q14457
LVPMGIPRTLMRTTR	CYP2S1	366	Q96SQ9
TMQMTPGEFRRPRLA	KANK1	171	Q14678
RMLAGGVRSMPSPLL	LINGO1	6	Q96FE5
VPIMVMAVTRPRDGA	OPRD1	181	P41143
MTTLAGAVPRMMRPG	PAX3	1	P23760
GDLGTRMMPIRRSAQ	PALS1	41	Q8N3R9
RMNRRMVGPDVIPLP	FAM189A2	161	Q15884
MPRGSRSRTSRMAPP	CHCHD2P9	1	Q5T1J5
MEGKPMRRCTNIRPG	KLHL20	1	Q9Y2M5
GRLMRRLPSVGGRMT	LINC00304	56	Q8N9R0
GRCVVMVGMPFPNIR	DDX11L8	791	A8MPP1
LRLMMPGRRGALREP	CBLN2	11	Q8IUK8
SMLLERMRGGAPPRE	MAMSTR	196	Q6ZN01
MGPGGRVARLLAPLM	MALSU1	1	Q96EH3
RGPMIDQRGLPMDGR	CSTF2T	396	Q9H0L4
RGMDARGLEMRGPVP	CSTF2T	451	Q9H0L4
VVVSGTPIRRPMGQM	FAH	166	P16930
LSRSHGMGRRQVMPP	FAM237B	106	A0A1B0GVD1
MLVRRGARAGPRMPR	CD34	1	P28906
EAMPMVRIVPRGHTA	OPLAH	221	O14841
RRGMTAQVGITMPRT	NAV2	1061	Q8IVL1
SRNRVIQPMGMSPRG	RIC8A	491	Q9NPQ8
MPSISRGRTMIHIPG	APC	2221	P25054
GGPGVIMSREVLRRM	CHSY1	221	Q86X52
GGPGMIFSREVLRRM	CHSY3	311	Q70JA7
RGPRRMTVIIPGMSA	TULP1	416	O00294
RGVPRTPVRQKMNTM	TICRR	561	Q7Z2Z1
RPKSGLIVRGMMSGP	MINDY4	201	Q4G0A6
RPRRINMTDTGISPM	SAGE1	226	Q9NXZ1
MPVMPIPRRVRSFHG	TMEM250	1	H0YL14
MVPAAGRRPPRVMRL	TXNDC15	1	Q96J42
MPSPRRSMEGRPLGV	PLPP6	1	Q8IY26
RPERIVVIMRGLPGS	YLPM1	1831	P49750
TLPVMLAMRLVRRGP	UTS2R	181	Q9UKP6
GGRMSRTRFIIMPTQ	THSD7B	1266	Q9C0I4
MAERPGSPGSREMRL	ZNF722	1	A0A1W2PQL4