Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionubiquitin protein ligase activity

RNF168 UBR4 TRIM63 RNF34 UHRF1 RNF213 TRIM71 HERC2 CBL

7.42e-06372729GO:0061630
GeneOntologyMolecularFunctionubiquitin-like protein ligase activity

RNF168 UBR4 TRIM63 RNF34 UHRF1 RNF213 TRIM71 HERC2 CBL

1.27e-05398729GO:0061659
GeneOntologyMolecularFunctionubiquitin-protein transferase activity

RNF168 UBR4 TRIM63 RNF34 UHRF1 RNF213 TRIM71 HERC2 CBL

4.93e-05473729GO:0004842
GeneOntologyMolecularFunctiondeath receptor activity

NGFR TNFRSF10C TNFRSF10B

5.71e-0521723GO:0005035
GeneOntologyMolecularFunctionTRAIL receptor activity

TNFRSF10C TNFRSF10B

7.66e-054722GO:0036463
GeneOntologyMolecularFunctionubiquitin-like protein transferase activity

RNF168 UBR4 TRIM63 RNF34 UHRF1 RNF213 TRIM71 HERC2 CBL

9.05e-05512729GO:0019787
GeneOntologyMolecularFunctionaminoacyltransferase activity

RNF168 UBR4 TRIM63 RNF34 UHRF1 RNF213 TRIM71 HERC2 CBL

1.21e-04532729GO:0016755
GeneOntologyMolecularFunctionNotch binding

DLL1 NOTCH4 CCN3

1.24e-0427723GO:0005112
GeneOntologyMolecularFunctionTRAIL binding

TNFRSF10C TNFRSF10B

1.27e-045722GO:0045569
GeneOntologyMolecularFunctionnodal binding

LEFTY2 LEFTY1

3.54e-048722GO:0038100
GeneOntologyMolecularFunctionhistone ubiquitin ligase activity

RNF168 UHRF1

8.27e-0412722GO:0140852
GeneOntologyMolecularFunctioncalcium ion binding

NELL1 FAT4 FBN1 DSC1 SLIT3 DLL1 CBL NOTCH4 CDH18

1.44e-03749729GO:0005509
GeneOntologyMolecularFunctionacyltransferase activity

RNF168 UBR4 TRIM63 RNF34 UHRF1 RNF213 TRIM71 HERC2 CBL

1.82e-03775729GO:0016746
GeneOntologyBiologicalProcesscirculatory system development

LEFTY2 LEFTY1 FAT4 ERBB4 IGF1R FBN1 PBRM1 TENM4 ACKR3 SLIT3 NGFR RNF213 FLRT3 DLL1 S1PR1 NOTCH4 CCN3

7.03e-0614427217GO:0072359
GeneOntologyBiologicalProcessheart development

LEFTY2 LEFTY1 FAT4 ERBB4 IGF1R FBN1 PBRM1 TENM4 SLIT3 FLRT3 DLL1 S1PR1

1.11e-057577212GO:0007507
GeneOntologyBiologicalProcessnegative regulation of nodal receptor complex assembly

LEFTY2 LEFTY1

1.20e-052722GO:1900124
GeneOntologyBiologicalProcessregulation of nodal receptor complex assembly

LEFTY2 LEFTY1

1.20e-052722GO:1900123
GeneOntologyBiologicalProcessnodal receptor complex assembly

LEFTY2 LEFTY1

1.20e-052722GO:0038099
GeneOntologyBiologicalProcessnegative regulation of cell population proliferation

LEFTY2 NELL1 LEFTY1 ERBB4 PBRM1 ZBTB17 ACKR3 TNFRSF8 SLIT3 WNT9A NGFR DLL1 CCN3

2.47e-059617213GO:0008285
GeneOntologyBiologicalProcesscellular response to growth factor stimulus

LEFTY1 KDM5B FAT4 ERBB4 IGF1R FBN1 NGFR KCP TRIM71 FLRT3 DLL1 CBL

3.50e-058507212GO:0071363
GeneOntologyBiologicalProcessresponse to growth factor

LEFTY1 KDM5B FAT4 ERBB4 IGF1R FBN1 NGFR KCP TRIM71 FLRT3 DLL1 CBL

5.06e-058837212GO:0070848
GeneOntologyBiologicalProcessenzyme-linked receptor protein signaling pathway

LEFTY2 LEFTY1 FAT4 ERBB4 IGF1R FBN1 RHBDF2 NGFR KCP TRIM71 FLRT3 DLL1 CBL CCN3

5.19e-0511867214GO:0007167
GeneOntologyBiologicalProcesstissue morphogenesis

KDM5B FAT4 ERBB4 IGF1R DEAF1 NGFR TRIM71 FLRT3 DLL1 S1PR1 NOTCH4

5.46e-057507211GO:0048729
GeneOntologyBiologicalProcessmorphogenesis of an epithelium

KDM5B FAT4 ERBB4 IGF1R DEAF1 NGFR TRIM71 FLRT3 DLL1 NOTCH4

5.53e-056197210GO:0002009
GeneOntologyBiologicalProcesscellular response to fibroblast growth factor stimulus

KDM5B FAT4 NGFR TRIM71 FLRT3

7.34e-05124725GO:0044344
GeneOntologyBiologicalProcessresponse to fibroblast growth factor

KDM5B FAT4 NGFR TRIM71 FLRT3

9.87e-05132725GO:0071774
GeneOntologyBiologicalProcessheart morphogenesis

LEFTY2 LEFTY1 FAT4 PBRM1 SLIT3 DLL1 S1PR1

1.28e-04321727GO:0003007
GeneOntologyBiologicalProcessprotein autoubiquitination

UHRF1 RNF213 TRIM71 CBL

1.60e-0478724GO:0051865
GeneOntologyBiologicalProcessnegative regulation of nodal signaling pathway

LEFTY2 LEFTY1

2.50e-047722GO:1900108
GeneOntologyBiologicalProcessmammary gland development

KDM5B ERBB4 IGF1R DEAF1 NOTCH4

2.57e-04162725GO:0030879
GeneOntologyBiologicalProcessextrinsic apoptotic signaling pathway via death domain receptors

RNF34 TNFRSF10C TNFRSF10B DEDD

3.15e-0493724GO:0008625
GeneOntologyBiologicalProcessubiquitin-dependent protein catabolic process

RNF168 UBR4 TRIM63 RNF34 UHRF1 RNF213 TRIM71 HERC2 CBL

3.75e-04640729GO:0006511
GeneOntologyBiologicalProcessfibroblast growth factor receptor signaling pathway

FAT4 NGFR TRIM71 FLRT3

3.85e-0498724GO:0008543
GeneOntologyBiologicalProcessmodification-dependent protein catabolic process

RNF168 UBR4 TRIM63 RNF34 UHRF1 RNF213 TRIM71 HERC2 CBL

4.25e-04651729GO:0019941
GeneOntologyBiologicalProcessregulation of nodal signaling pathway

LEFTY2 LEFTY1

4.26e-049722GO:1900107
GeneOntologyBiologicalProcessmodification-dependent macromolecule catabolic process

RNF168 UBR4 TRIM63 RNF34 UHRF1 RNF213 TRIM71 HERC2 CBL

4.49e-04656729GO:0043632
GeneOntologyBiologicalProcesstube morphogenesis

KDM5B FAT4 PBRM1 DEAF1 ACKR3 NGFR RNF213 TRIM71 DLL1 S1PR1 NOTCH4 CCN3

4.83e-0411257212GO:0035239
GeneOntologyBiologicalProcessprotein polyubiquitination

RNF168 UBR4 RNF34 RNF213 TRIM71 CBL

5.17e-04289726GO:0000209
GeneOntologyBiologicalProcessnegative regulation of Notch signaling pathway

HERC2 DLL1 NOTCH4

6.30e-0448723GO:0045746
GeneOntologyCellularComponentmembrane raft

ERBB4 IGF1R TNFRSF10C TNFRSF10B DLL1 CBL S1PR1

2.26e-04362717GO:0045121
GeneOntologyCellularComponentmembrane microdomain

ERBB4 IGF1R TNFRSF10C TNFRSF10B DLL1 CBL S1PR1

2.34e-04364717GO:0098857
MousePhenoabnormal left renal vein morphology

LEFTY2 LEFTY1

1.52e-052552MP:0011327
MousePhenoabnormal renal vein morphology

LEFTY2 LEFTY1

1.52e-052552MP:0011323
MousePhenoabnormal presacral vertebrae morphology

NELL1 FAT4 FBN1 DEAF1 TENM4 WNT9A DLL1

2.68e-05225557MP:0000459
MousePhenoabnormal aorta tunica intima morphology

FBN1 S1PR1

4.55e-053552MP:0009872
MousePhenoabnormal kidney venous blood vessel morphology

LEFTY2 LEFTY1

4.55e-053552MP:0011311
MousePhenoabnormal cardiovascular development

LEFTY2 LEFTY1 ERBB4 FAM120B ACKR3 UBR4 NGFR RNF213 FLRT3 DLL1 S1PR1 CCN3

5.22e-058025512MP:0002925
MousePhenoabnormal NK cell morphology

FBN1 DCLRE1C UHRF1 TNFRSF10C TNFRSF10B S1PR1

7.89e-05183556MP:0005068
MousePhenoabnormal large intestine placement

LEFTY2 LEFTY1

9.07e-054552MP:0003284
MousePhenoabnormal heart septum morphology

LEFTY2 LEFTY1 FAT4 FAM120B PBRM1 ACKR3 SLIT3 CCN3

1.27e-04388558MP:0006113
MousePhenoenlarged chest

FBN1 CCN3

1.51e-045552MP:0001267
MousePhenoabnormal vertebral column morphology

NELL1 FAT4 FBN1 DEAF1 TENM4 RNF168 CNTNAP1 WNT9A DLL1 SSPOP CCN3

2.06e-047875511MP:0004703
MousePhenoabnormal heart ventricle morphology

LEFTY2 LEFTY1 ERBB4 FAM120B FBN1 PBRM1 ACKR3 SLIT3 TRIM63 CBL CCN3

2.20e-047935511MP:0005294
MousePhenoabsent heart right ventricle

LEFTY2 LEFTY1

2.26e-046552MP:0003872
MousePhenoabnormal germ layer development

LEFTY2 LEFTY1 ZBTB17 UHRF1 FLRT3

2.49e-04144555MP:0001674
MousePhenoabnormal vertebrae morphology

NELL1 FAT4 FBN1 DEAF1 TENM4 RNF168 WNT9A DLL1 CCN3

2.53e-04546559MP:0000137
MousePhenoincreased NK cell number

DCLRE1C UHRF1 TNFRSF10C TNFRSF10B

2.99e-0482554MP:0008044
MousePhenoembryonic lethality during organogenesis, complete penetrance

LEFTY2 LEFTY1 ERBB4 FBN1 TENM4 UBR4 UHRF1 TRIM71 DLL1 S1PR1

3.51e-047005510MP:0011098
MousePhenoabnormal heart right ventricle morphology

LEFTY2 LEFTY1 FBN1 ACKR3 SLIT3

3.60e-04156555MP:0003920
MousePhenoabnormal interventricular septum morphology

LEFTY2 LEFTY1 FAM120B PBRM1 ACKR3 SLIT3 CCN3

3.65e-04342557MP:0000281
MousePhenoleft atrial isomerism

LEFTY2 LEFTY1

4.19e-048552MP:0008461
MousePhenoembryonic lethality during organogenesis

LEFTY2 LEFTY1 ERBB4 FBN1 TENM4 UBR4 UHRF1 TRIM71 FLRT3 DLL1 S1PR1

5.16e-048765511MP:0006207
MousePhenoaccessory spleen

LEFTY2 LEFTY1

5.38e-049552MP:0003342
MousePhenotricuspid valve atresia

LEFTY2 LEFTY1

5.38e-049552MP:0006123
MousePhenononsyndromic hearing impairment

USP53 OTOG

5.38e-049552MP:0006328
MousePhenoabnormal NK cell number

DCLRE1C UHRF1 TNFRSF10C TNFRSF10B S1PR1

5.63e-04172555MP:0008043
DomainEGF_3

NELL1 FAT4 FBN1 MALRD1 TENM4 ADAM21 CNTNAP1 SLIT3 DLL1 SSPOP NOTCH4 OTOG

5.57e-112356912PS50026
DomainVWF_dom

NELL1 VWF PXDNL KCP SSPOP CCN3 OTOG

1.67e-1042697IPR001007
DomainEGF-like_dom

NELL1 FAT4 FBN1 MALRD1 TENM4 ADAM21 CNTNAP1 SLIT3 DLL1 NOTCH4 OTOG

1.75e-092496911IPR000742
DomainEGF_1

NELL1 FAT4 FBN1 MALRD1 TENM4 ADAM21 CNTNAP1 SLIT3 DLL1 SSPOP NOTCH4

2.25e-092556911PS00022
DomainEGF_2

NELL1 FAT4 FBN1 MALRD1 TENM4 ADAM21 CNTNAP1 SLIT3 DLL1 SSPOP NOTCH4

3.36e-092656911PS01186
DomainVWFC_1

NELL1 VWF PXDNL KCP SSPOP CCN3

3.63e-0936696PS01208
DomainVWC

NELL1 VWF PXDNL KCP SSPOP CCN3

5.12e-0938696SM00214
DomainVWFC_2

NELL1 VWF PXDNL KCP SSPOP CCN3

5.12e-0938696PS50184
DomainGrowth_fac_rcpt_

NELL1 FAT4 ERBB4 IGF1R FBN1 SLIT3 DLL1 NOTCH4 CCN3

5.80e-09156699IPR009030
DomainVWC_out

NELL1 VWF KCP SSPOP OTOG

6.63e-0919695SM00215
Domain-

KDM5B RNF168 USP51 MEX3D TRIM63 RNF34 UHRF1 RNF213 TRIM71 CBL FGD6 RUFY4 SP140

8.56e-0944969133.30.40.10
DomainZnf_RING/FYVE/PHD

KDM5B RNF168 USP51 MEX3D TRIM63 RNF34 UHRF1 RNF213 TRIM71 CBL FGD6 RUFY4 SP140

1.11e-084596913IPR013083
DomainCys_knot_C

VWF SLIT3 SSPOP CCN3 OTOG

2.98e-0825695IPR006207
DomainCTCK_2

VWF SLIT3 SSPOP CCN3 OTOG

2.98e-0825695PS01225
DomainEGF-like_CS

NELL1 FAT4 FBN1 MALRD1 TENM4 ADAM21 CNTNAP1 SLIT3 DLL1 NOTCH4

3.94e-082616910IPR013032
DomainVWC

NELL1 VWF PXDNL KCP CCN3

5.46e-0828695PF00093
DomainUnchr_dom_Cys-rich

VWF KCP SSPOP OTOG

1.19e-0713694IPR014853
DomainC8

VWF KCP SSPOP OTOG

1.19e-0713694SM00832
DomainTIL_dom

VWF KCP SSPOP OTOG

1.66e-0714694IPR002919
DomainEGF

NELL1 FAT4 FBN1 MALRD1 TENM4 CNTNAP1 SLIT3 DLL1 NOTCH4

1.99e-07235699SM00181
DomainVWD

VWF KCP SSPOP OTOG

3.00e-0716694SM00216
DomainVWF_type-D

VWF KCP SSPOP OTOG

3.00e-0716694IPR001846
DomainVWFD

VWF KCP SSPOP OTOG

3.00e-0716694PS51233
DomainVWD

VWF KCP SSPOP OTOG

3.00e-0716694PF00094
DomainCTCK_1

VWF SLIT3 SSPOP CCN3

5.02e-0718694PS01185
DomainTNFR_c6

TNFRSF8 NGFR TNFRSF10C TNFRSF10B

1.19e-0622694PF00020
DomainCT

VWF SLIT3 CCN3 OTOG

1.19e-0622694SM00041
DomainEGF_Ca-bd_CS

NELL1 FAT4 FBN1 SLIT3 DLL1 NOTCH4

1.55e-0697696IPR018097
DomainEGF_CA

NELL1 FAT4 FBN1 SLIT3 DLL1 NOTCH4

1.74e-0699696PS01187
DomainTNFR

TNFRSF8 NGFR TNFRSF10C TNFRSF10B

2.40e-0626694SM00208
DomainEGF-type_Asp/Asn_hydroxyl_site

NELL1 FAT4 FBN1 SLIT3 DLL1 NOTCH4

2.60e-06106696IPR000152
DomainTNFR_NGFR_1

TNFRSF8 NGFR TNFRSF10C TNFRSF10B

3.78e-0629694PS00652
DomainTNFR_NGFR_2

TNFRSF8 NGFR TNFRSF10C TNFRSF10B

3.78e-0629694PS50050
DomainEGF_CA

NELL1 FAT4 FBN1 SLIT3 DLL1 NOTCH4

5.88e-06122696SM00179
DomainTNFR/NGFR_Cys_rich_reg

TNFRSF8 NGFR TNFRSF10C TNFRSF10B

6.44e-0633694IPR001368
DomainEGF-like_Ca-bd_dom

NELL1 FAT4 FBN1 SLIT3 DLL1 NOTCH4

6.46e-06124696IPR001881
DomainTIL

VWF SSPOP OTOG

1.04e-0512693PF01826
DomainC8

VWF SSPOP OTOG

1.04e-0512693PF08742
DomainLRDF

LEFTY2 LEFTY1

1.35e-052692IPR003942
DomainZF_RING_2

RNF168 MEX3D TRIM63 RNF34 UHRF1 RNF213 TRIM71 CBL

1.37e-05298698PS50089
DomainLaminin_G_2

NELL1 FAT4 CNTNAP1 SLIT3

1.41e-0540694PF02210
DomainRING

RNF168 MEX3D TRIM63 RNF34 UHRF1 RNF213 TRIM71 CBL

1.63e-05305698SM00184
DomainZnf_FYVE_PHD

KDM5B RNF34 UHRF1 FGD6 RUFY4 SP140

1.71e-05147696IPR011011
DomainLamG

NELL1 FAT4 CNTNAP1 SLIT3

2.07e-0544694SM00282
DomainZnf_RING

RNF168 MEX3D TRIM63 RNF34 UHRF1 RNF213 TRIM71 CBL

2.62e-05326698IPR001841
DomainASX_HYDROXYL

NELL1 FAT4 FBN1 DLL1 NOTCH4

3.41e-05100695PS00010
DomainLaminin_G

NELL1 FAT4 CNTNAP1 SLIT3

6.23e-0558694IPR001791
DomainTNFR_10

TNFRSF10C TNFRSF10B

8.03e-054692IPR020465
DomainZF_RING_1

RNF168 MEX3D TRIM63 RNF34 UHRF1 TRIM71 CBL

9.80e-05291697PS00518
DomainEGF

MALRD1 CNTNAP1 SLIT3 DLL1 NOTCH4

1.03e-04126695PF00008
DomainhEGF

FAT4 DLL1 NOTCH4

1.48e-0428693PF12661
DomainFurin-like

ERBB4 IGF1R

2.79e-047692PF00757
DomainRcpt_L-dom

ERBB4 IGF1R

2.79e-047692IPR000494
DomainFurin-like_Cys-rich_dom

ERBB4 IGF1R

2.79e-047692IPR006211
DomainRecep_L_domain

ERBB4 IGF1R

2.79e-047692PF01030
Domain-

ERBB4 IGF1R

2.79e-0476923.80.20.20
DomainEGF_CA

NELL1 FAT4 FBN1 NOTCH4

2.88e-0486694PF07645
DomainLAM_G_DOMAIN

FAT4 CNTNAP1 SLIT3

3.71e-0438693PS50025
DomainSAND_dom

DEAF1 SP140

3.71e-048692IPR000770
DomainSAND

DEAF1 SP140

3.71e-048692PF01342
DomainSAND

DEAF1 SP140

3.71e-048692PS50864
DomainSAND

DEAF1 SP140

3.71e-048692SM00258
Domain-

NELL1 FAT4 CNTNAP1 SLIT3

4.22e-04956942.60.120.200
DomainZF_FYVE

RNF34 FGD6 RUFY4

4.32e-0440693PS50178
Domain-

DEAF1 SP140

8.67e-04126923.10.390.10
DomainSAND_dom-like

DEAF1 SP140

8.67e-0412692IPR010919
DomainNHL

TENM4 TRIM71

1.02e-0313692PS51125
DomainConA-like_dom

NELL1 FAT4 MALRD1 CNTNAP1 SLIT3

1.29e-03219695IPR013320
Domainzf-C3HC4

RNF168 MEX3D TRIM63 RNF213 CBL

1.40e-03223695PF00097
DomainTSP_1

THSD7B SSPOP CCN3

1.64e-0363693PF00090
DomainTSP1

THSD7B SSPOP CCN3

1.79e-0365693SM00209
DomainTSP1_rpt

THSD7B SSPOP CCN3

1.79e-0365693IPR000884
DomainTSP1

THSD7B SSPOP CCN3

1.79e-0365693PS50092
DomainRib_L2_dom2

UHRF1 HERC2

1.98e-0318692IPR014722
Domain-

UHRF1 HERC2

1.98e-03186922.30.30.30
DomainFurin_repeat

ERBB4 IGF1R

1.98e-0318692IPR006212
DomainFU

ERBB4 IGF1R

1.98e-0318692SM00261
Domain-

CNTNAP1 HERC2 SSPOP

2.49e-03736932.60.120.260
DomainPHD

KDM5B UHRF1 SP140

2.69e-0375693PF00628
DomainFA58C

CNTNAP1 SSPOP

2.70e-0321692SM00231
DomainFA58C_3

CNTNAP1 SSPOP

2.70e-0321692PS50022
DomainFA58C_1

CNTNAP1 SSPOP

2.70e-0321692PS01285
DomainFA58C_2

CNTNAP1 SSPOP

2.70e-0321692PS01286
DomainZnf_RING_CS

TRIM63 UHRF1 TRIM71 CBL

3.11e-03163694IPR017907
DomainZnf_PHD-finger

KDM5B UHRF1 SP140

3.12e-0379693IPR019787
DomainF5_F8_type_C

CNTNAP1 SSPOP

3.52e-0324692PF00754
DomainFA58C

CNTNAP1 SSPOP

3.52e-0324692IPR000421
PathwayKEGG_MEDICUS_REFERENCE_REGULATION_OF_GF_RTK_RAS_ERK_SIGNALING_UBIQUITINATION_OF_RTK_BY_CBL

ERBB4 IGF1R NGFR CBL

1.82e-0625514M47934
PathwayPID_NOTCH_PATHWAY

DLL1 CBL SSPOP NOTCH4

5.97e-0559514M17
PathwayKEGG_MEDICUS_VARIANT_AMPLIFIED_MYCN_TO_TRANSCRIPTIONAL_REPRESSION

ZBTB17 NGFR

1.91e-046512M47445
Pubmed

Notch signaling regulates left-right asymmetry determination by inducing Nodal expression.

LEFTY2 LEFTY1 DLL1

4.73e-07872312730124
Pubmed

O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.

LEFTY2 LEFTY1 THSD7B SSPOP CCN3

5.09e-077572520637190
Pubmed

Notch activity induces Nodal expression and mediates the establishment of left-right asymmetry in vertebrate embryos.

LEFTY2 LEFTY1 DLL1

7.08e-07972312730123
Pubmed

The TNF and TNF receptor superfamilies: integrating mammalian biology.

TNFRSF8 NGFR TNFRSF10C TNFRSF10B

1.31e-063972411239407
Pubmed

Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity.

RNF168 UBR4 RNF213 HERC2 CBL

1.66e-069572529643511
Pubmed

Node and midline defects are associated with left-right development in Delta1 mutant embryos.

LEFTY2 LEFTY1 DLL1

2.40e-061372312441287
Pubmed

Notch signaling is required for the maintenance of enteric neural crest progenitors.

NGFR DLL1 NOTCH4

2.40e-061372318832397
Pubmed

The ubiquitin ligase TRIM25 targets ERG for degradation in prostate cancer.

UBR4 UHRF1 HERC2

3.05e-061472327626314
Pubmed

Defective Nodal and Cerl2 expression in the Arl13b(hnn) mutant node underlie its heterotaxia.

LEFTY2 LEFTY1 DLL1

3.05e-061472322554696
Pubmed

Baf60c is a nuclear Notch signaling component required for the establishment of left-right asymmetry.

LEFTY2 LEFTY1 DLL1

3.05e-061472317210915
Pubmed

LEFTY2 alleviates hepatic stellate cell activation and liver fibrosis by regulating the TGF-β1/Smad3 pathway.

LEFTY2 LEFTY1

4.23e-06272232745796
Pubmed

LEFTY, a member of the transforming growth factor-beta superfamily, inhibits uterine stromal cell differentiation: a novel autocrine role.

LEFTY2 LEFTY1

4.23e-06272220056823
Pubmed

Characterization and mutation analysis of human LEFTY A and LEFTY B, homologues of murine genes implicated in left-right axis development.

LEFTY2 LEFTY1

4.23e-06272210053005
Pubmed

Mutation analysis of human LEFTY A and LEFTY B genes in children with Ivemark syndrome.

LEFTY2 LEFTY1

4.23e-06272211100524
Pubmed

Lefty1 and lefty2 control the balance between self-renewal and pluripotent differentiation of mouse embryonic stem cells.

LEFTY2 LEFTY1

4.23e-06272224147624
Pubmed

Lefty antagonises TGF-beta1 induced epithelial-mesenchymal transition in tubular epithelial cells.

LEFTY2 LEFTY1

4.23e-06272220171171
Pubmed

Stra3/lefty, a retinoic acid-inducible novel member of the transforming growth factor-beta superfamily.

LEFTY2 LEFTY1

4.23e-0627229496783
Pubmed

A functional role of LEFTY during progesterone therapy for endometrial carcinoma.

LEFTY2 LEFTY1

4.23e-06272229268772
Pubmed

Cytotoxic effects of camptothecin and cisplatin combined with tumor necrosis factor-related apoptosis-inducing ligand (Apo2L/TRAIL) in a model of primary culture of non-small cell lung cancer.

TNFRSF10C TNFRSF10B

4.23e-06272219661294
Pubmed

Lefty1 Ameliorates Post-infarction Fibrosis by Suppressing p-Smad2 and p-ERK1/2 Signaling Pathways.

LEFTY2 LEFTY1

4.23e-06272233409963
Pubmed

LEFTY2 inhibits endometrial receptivity by downregulating Orai1 expression and store-operated Ca2+ entry.

LEFTY2 LEFTY1

4.23e-06272229230527
Pubmed

Molecular analysis of LEFTY-expressing cells in early human embryoid bodies.

LEFTY2 LEFTY1

4.23e-06272217038673
Pubmed

Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors.

TNFRSF10C TNFRSF10B

4.23e-0627229242611
Pubmed

Anti-inflammatory effects of Lefty-1 in renal tubulointerstitial inflammation via regulation of the NF-κB pathway.

LEFTY2 LEFTY1

4.23e-06272229286065
Pubmed

Tryptophol induces death receptor (DR) 5-mediated apoptosis in U937 cells.

TNFRSF10C TNFRSF10B

4.23e-06272217690453
Pubmed

FAT4-USP51 complex regulates the proliferation and invasion of endometrial cancer via Hippo pathway.

FAT4 USP51

4.23e-06272231217854
Pubmed

Isolation, characterization, and function of EBAF/LEFTY B: role in infertility.

LEFTY2 LEFTY1

4.23e-06272221401636
Pubmed

Lefty is expressed in mouse endometrium in estrous cycle and peri-implantation period.

LEFTY2 LEFTY1

4.23e-06272215640253
Pubmed

c-Cbl binds to tyrosine-phosphorylated neurotrophin receptor p75 and induces its ubiquitination.

NGFR CBL

4.23e-06272215337528
Pubmed

Rotatin is a novel gene required for axial rotation and left-right specification in mouse embryos.

LEFTY2 LEFTY1 DLL1

4.67e-061672311900971
Pubmed

HNF3beta and Lim1 interact in the visceral endoderm to regulate primitive streak formation and anterior-posterior polarity in the mouse embryo.

LEFTY2 LEFTY1 DLL1

9.46e-062072310498685
Pubmed

BMP signaling in the epiblast is required for proper recruitment of the prospective paraxial mesoderm and development of the somites.

LEFTY2 LEFTY1 DLL1

9.46e-062072316943278
Pubmed

UBE2S interacting with TRIM21 mediates the K11-linked ubiquitination of LPP to promote the lymphatic metastasis of bladder cancer.

UBR4 RNF213 HERC2

1.10e-052172337422473
Pubmed

Wnt3a links left-right determination with segmentation and anteroposterior axis elongation.

LEFTY2 LEFTY1 DLL1

1.10e-052172316291790
Pubmed

Nodal and lefty signaling regulates the growth of pancreatic cells.

LEFTY2 LEFTY1

1.27e-05372218393305
Pubmed

Lefty-1 inhibits renal epithelial-mesenchymal transition by antagonizing the TGF-β/Smad signaling pathway.

LEFTY2 LEFTY1

1.27e-05372232065356
Pubmed

c-Cbl-mediated degradation of TRAIL receptors is responsible for the development of the early phase of TRAIL resistance.

TNFRSF10B CBL

1.27e-05372219932172
Pubmed

Role of asymmetric signals in left-right patterning in the mouse.

LEFTY2 LEFTY1

1.27e-05372211471154
Pubmed

Decidual differentiation of stromal cells promotes Proprotein Convertase 5/6 expression and lefty processing.

LEFTY2 LEFTY1

1.27e-05372216141390
Pubmed

Chloroquine enhances TRAIL-mediated apoptosis through up-regulation of DR5 by stabilization of mRNA and protein in cancer cells.

TNFRSF10B CBL

1.27e-05372226964637
Pubmed

The nephroblastoma overexpressed gene (NOV/ccn3) protein associates with Notch1 extracellular domain and inhibits myoblast differentiation via Notch signaling pathway.

DLL1 CCN3

1.27e-05372212050162
Pubmed

P44, the 'longevity-assurance' isoform of P53, regulates tau phosphorylation and is activated in an age-dependent fashion.

IGF1R NGFR

1.27e-05372224341977
Pubmed

IFT46 plays an essential role in cilia development.

LEFTY2 LEFTY1

1.27e-05372225722189
Pubmed

Distinct transcriptional regulation and phylogenetic divergence of human LEFTY genes.

LEFTY2 LEFTY1

1.27e-05372210886363
Pubmed

Association of maternal hypertension and diabetes with variants of the NKX2-5, LEFTY1 and LEFTY2 genes in children with congenital heart defects: a case-control study from Pakistani Population.

LEFTY2 LEFTY1

1.27e-05372237097539
Pubmed

CCN3 and DLL1 co-regulate osteogenic differentiation of mouse embryonic fibroblasts in a Hey1-dependent manner.

DLL1 CCN3

1.27e-05372230538222
Pubmed

Proteomic identification and validation of novel interactions of the putative tumor suppressor PRELP with membrane proteins including IGFI-R and p75NTR.

IGF1R NGFR

1.27e-05372233428936
Pubmed

Lefty-1 alleviates TGF-β1-induced fibroblast-myofibroblast transdifferentiation in NRK-49F cells.

LEFTY2 LEFTY1

1.27e-05372226316705
Pubmed

Integrity of intracellular domain of Notch ligand is indispensable for cleavage required for release of the Notch2 intracellular domain.

DLL1 NOTCH4

1.27e-05372211823422
Pubmed

Generation of robust left-right asymmetry in the mouse embryo requires a self-enhancement and lateral-inhibition system.

LEFTY2 LEFTY1

1.27e-05372217011489
Pubmed

Novel Helicobacter species H.japonicum isolated from laboratory mice from Japan induces typhlocolitis and lower bowel carcinoma in C57BL/129 IL10-/- mice.

LEFTY2 LEFTY1

1.27e-05372227655833
Pubmed

Differential inhibition of TRAIL-mediated DR5-DISC formation by decoy receptors 1 and 2.

TNFRSF10C TNFRSF10B

1.27e-05372216980609
Pubmed

Embryonic asymmetry: the left side gets all the best genes.

LEFTY2 LEFTY1

1.27e-0537229889116
Pubmed

Characterization of two receptors for TRAIL.

TNFRSF10C TNFRSF10B

1.27e-0537229373179
Pubmed

Two modes by which Lefty proteins inhibit nodal signaling.

LEFTY2 LEFTY1

1.27e-05372215062104
Pubmed

An antagonist decoy receptor and a death domain-containing receptor for TRAIL.

TNFRSF10C TNFRSF10B

1.27e-0537229242610
Pubmed

Requirements of LEFTY and Nodal overexpression for tumor cell survival under hypoxia in glioblastoma.

LEFTY2 LEFTY1

1.27e-05372233111989
Pubmed

Lefty1 alleviates renal tubulointerstitial injury in mice with unilateral ureteral obstruction.

LEFTY2 LEFTY1

1.27e-05372226647776
Pubmed

TGFβ signaling in establishing left-right asymmetry.

LEFTY2 LEFTY1

1.27e-05372224704359
Pubmed

Randomization of left-right asymmetry due to loss of nodal cilia generating leftward flow of extraembryonic fluid in mice lacking KIF3B motor protein.

LEFTY2 LEFTY1

1.27e-0537229865700
Pubmed

Nodal activates smad and extracellular signal-regulated kinases 1/2 pathways promoting renal cell carcinoma proliferation.

LEFTY2 LEFTY1

1.27e-05372225672326
Pubmed

Elevation of LncRNA ENST00000453774.1 Prevents Renal Fibrosis by Upregulating FBN1, IGF1R, and KLF7.

IGF1R FBN1

1.27e-05372234614499
Pubmed

Identification of single nucleotide polymorphisms in the tumor necrosis factor (TNF) and TNF receptor superfamily in the Korean population.

TNFRSF8 TNFRSF10C TNFRSF10B

1.27e-052272315301860
Pubmed

Genetic ablation of FLRT3 reveals a novel morphogenetic function for the anterior visceral endoderm in suppressing mesoderm differentiation.

LEFTY2 LEFTY1 FLRT3

1.89e-052572319056886
Pubmed

Comparative analysis of apoptosis and inflammation genes of mice and humans.

NGFR TNFRSF10C TNFRSF10B DEDD

2.37e-058072412819136
Pubmed

Asymmetric Nodal expression in the mouse is governed by the combinatorial activities of two distinct regulatory elements.

LEFTY2 LEFTY1

2.53e-05472215454269
Pubmed

TRAIL receptor deficiency sensitizes mice to dextran sodium sulphate-induced colitis and colitis-associated carcinogenesis.

TNFRSF10C TNFRSF10B

2.53e-05472224117005
Pubmed

The dynamic right-to-left translocation of Cerl2 is involved in the regulation and termination of Nodal activity in the mouse node.

LEFTY2 LEFTY1

2.53e-05472223544137
Pubmed

Membrane expression of TRAIL receptors DR4, DR5, DcR1 and DcR2 in the normal endometrium, atypical endometrial hyperplasia and endometrioid adenocarcinoma: a tissue microarray study.

TNFRSF10C TNFRSF10B

2.53e-05472223584885
Pubmed

Blockade of TRAIL pathway ameliorates HBV-induced hepatocyte apoptosis in an acute hepatitis model.

TNFRSF10C TNFRSF10B

2.53e-05472217126290
Pubmed

TRAIL-R Deficient Mice Are Protected from Neurotoxic Effects of Amyloid-β.

TNFRSF10C TNFRSF10B

2.53e-05472236232931
Pubmed

TRAIL-R deficiency in mice promotes susceptibility to chronic inflammation and tumorigenesis.

TNFRSF10C TNFRSF10B

2.53e-05472218079962
Pubmed

TRAIL-R as a negative regulator of innate immune cell responses.

TNFRSF10C TNFRSF10B

2.53e-05472215589175
Pubmed

ErbB2 and ErbB4 Cbl binding sites can functionally replace the ErbB1 Cbl binding site.

ERBB4 CBL

2.53e-05472219263517
Pubmed

TRAIL decoy receptors mediate resistance of acute myeloid leukemia cells to TRAIL.

TNFRSF10C TNFRSF10B

2.53e-05472215921376
Pubmed

T Cell-Specific Deletion of TRAIL Receptor Reveals Its Critical Role for Regulating Pathologic T Cell Activation and Disease Induction in Experimental Autoimmune Encephalomyelitis.

TNFRSF10C TNFRSF10B

2.53e-05472235264458
Pubmed

The anterior visceral endoderm of the mouse embryo is established from both preimplantation precursor cells and by de novo gene expression after implantation.

LEFTY2 LEFTY1

2.53e-05472217662710
Pubmed

The expression pattern of nodal and lefty in the mouse mutant Ft suggests a function in the establishment of handedness.

LEFTY2 LEFTY1

2.53e-0547229376323
Pubmed

Adoptively transferred TRAIL+ T cells suppress GVHD and augment antitumor activity.

TNFRSF10C TNFRSF10B

2.53e-05472223676461
Pubmed

Inhibition of IGF-1R-dependent PI3K activation sensitizes colon cancer cells specifically to DR5-mediated apoptosis but not to rhTRAIL.

IGF1R TNFRSF10B

2.53e-05472221538027
Pubmed

Wnt3a-dependent and -independent protein interaction networks of chromatin-bound β-catenin in mouse embryonic stem cells.

LEFTY2 LEFTY1

2.53e-05472223592333
Pubmed

Two closely-related left-right asymmetrically expressed genes, lefty-1 and lefty-2: their distinct expression domains, chromosomal linkage and direct neuralizing activity in Xenopus embryos.

LEFTY2 LEFTY1

2.53e-0547229348041
Pubmed

Death receptor 5 contributes to cardiomyocyte hypertrophy through epidermal growth factor receptor transactivation.

TNFRSF10C TNFRSF10B

2.53e-05472231473246
Pubmed

Endoplasmic Reticulum Stress Activated by Androgen Enhances Apoptosis of Granulosa Cells via Induction of Death Receptor 5 in PCOS.

TNFRSF10C TNFRSF10B

2.53e-05472230423122
Pubmed

Induction of tumor-specific T cell immunity by anti-DR5 antibody therapy.

TNFRSF10C TNFRSF10B

2.53e-05472214769851
Pubmed

TNFRSF10A downregulation induces retinal pigment epithelium degeneration during the pathogenesis of age-related macular degeneration and central serous chorioretinopathy.

TNFRSF10C TNFRSF10B

2.53e-05472235103281
Pubmed

The role of the brachyury gene in heart development and left-right specification in the mouse.

LEFTY2 LEFTY1

2.53e-05472210349618
Pubmed

The murine TRAIL receptor signals caspase-independent cell death through ceramide.

TNFRSF10C TNFRSF10B

2.53e-05472217026999
Pubmed

Membrane expression of the death ligand trail receptors DR4 and DR5 in the normal endometrium, endometrial atypical hyperplasia and endometrioid endometrial cancer.

TNFRSF10C TNFRSF10B

2.53e-05472223815209
Pubmed

Distinct transcriptional regulatory mechanisms underlie left-right asymmetric expression of lefty-1 and lefty-2.

LEFTY2 LEFTY1

2.53e-0547229990851
Pubmed

TRAIL-R1 is a negative regulator of pro-inflammatory responses and modulates long-term sequelae resulting from Chlamydia trachomatis infections in humans.

TNFRSF10C TNFRSF10B

2.53e-05472224695582
Pubmed

Activation of TRAIL-DR5 pathway promotes sensorineural degeneration in the inner ear.

TNFRSF10C TNFRSF10B

2.53e-05472226791792
Pubmed

Antagonistic effect of the matricellular signaling protein CCN3 on TGF-beta- and Wnt-mediated fibrillinogenesis in systemic sclerosis and Marfan syndrome.

FBN1 CCN3

2.53e-05472220182440
Pubmed

Different downstream pathways for Notch signaling are required for gliogenic and chondrogenic specification of mouse mesencephalic neural crest cells.

NGFR DLL1

2.53e-05472218299190
Pubmed

LEFTYA Activates the Epithelial Na+ Channel (ENaC) in Endometrial Cells via Serum and Glucocorticoid Inducible Kinase SGK1.

LEFTY2 LEFTY1

2.53e-05472227606670
Pubmed

Induction of death receptor 5 expression in tumor vasculature by perifosine restores the vascular disruption activity of TRAIL-expressing CD34(+) cells.

TNFRSF10C TNFRSF10B

2.53e-05472223605004
Pubmed

Pitx2, a bicoid-type homeobox gene, is involved in a lefty-signaling pathway in determination of left-right asymmetry.

LEFTY2 LEFTY1

2.53e-0547229708732
Pubmed

lefty-1 is required for left-right determination as a regulator of lefty-2 and nodal.

LEFTY2 LEFTY1

2.53e-0547229708731
Pubmed

Death receptor 5 is required for intestinal stem cell activity during intestinal epithelial renewal at homoeostasis.

TNFRSF10C TNFRSF10B

2.53e-05472238199990
Pubmed

The ErbB4 CYT2 variant protects EGFR from ligand-induced degradation to enhance cancer cell motility.

ERBB4 CBL

2.53e-05472225140053
InteractionEGFL7 interactions

NELL1 IGF1R ADAM21 UBR4 NOTCH4

7.63e-0677715int:EGFL7
InteractionUBE2D2 interactions

RNF168 UBR4 TRIM63 RNF34 UHRF1 RNF213 HERC2 CBL

1.58e-05318718int:UBE2D2
InteractionUBE2N interactions

IGF1R RNF168 RHBDF2 TRIM63 UHRF1 RNF213 HERC2 CBL

3.20e-05351718int:UBE2N
InteractionUBE2D3 interactions

RNF168 TRIM63 RNF34 UHRF1 RNF213 HERC2 CBL

6.17e-05283717int:UBE2D3
InteractionLEFTY1 interactions

LEFTY2 LEFTY1

7.31e-054712int:LEFTY1
InteractionLEFTY2 interactions

LEFTY2 LEFTY1

7.31e-054712int:LEFTY2
InteractionUBE2D1 interactions

RNF168 TRIM63 RNF34 UHRF1 TRIM71 HERC2 CBL

7.84e-05294717int:UBE2D1
Cytoband8p22-p21

TNFRSF10C TNFRSF10B

7.27e-0637228p22-p21
Cytoband1q42.1

LEFTY2 LEFTY1

1.58e-04127221q42.1
GeneFamilyRing finger proteins

RNF168 MEX3D TRIM63 RNF34 UHRF1 RNF213 TRIM71 CBL

6.80e-0727549858
GeneFamilyCD molecules|Tumor necrosis factor receptor superfamily|Death inducing signaling complex

TNFRSF8 NGFR TNFRSF10C TNFRSF10B

1.08e-0629494782
GeneFamilyADAM metallopeptidase domain containing|CD molecules

IGF1R TNFRSF8 NGFR TNFRSF10C TNFRSF10B S1PR1

6.53e-04394496471
GeneFamilyPHD finger proteins

KDM5B UHRF1 SP140

1.86e-039049388
GeneFamilyZinc fingers FYVE-type|Pleckstrin homology domain containing|Rho guanine nucleotide exchange factors

FGD6 RUFY4

3.18e-033149281
CoexpressionNABA_ECM_GLYCOPROTEINS

NELL1 FBN1 VWF PXDNL SLIT3 KCP SSPOP CCN3 OTOG

3.04e-09196719M3008
CoexpressionNABA_ECM_GLYCOPROTEINS

NELL1 FBN1 VWF SLIT3 KCP SSPOP CCN3 OTOG

4.93e-08191718MM17059
CoexpressionNABA_CORE_MATRISOME

NELL1 FBN1 VWF PXDNL SLIT3 KCP SSPOP CCN3 OTOG

5.70e-08275719M5884
CoexpressionNABA_CORE_MATRISOME

NELL1 FBN1 VWF SLIT3 KCP SSPOP CCN3 OTOG

6.94e-07270718MM17057
CoexpressionNABA_MATRISOME

LEFTY2 NELL1 LEFTY1 FBN1 VWF ADAM21 PXDNL SLIT3 WNT9A KCP SSPOP CCN3 OTOG

3.32e-0610267113M5889
CoexpressionNABA_MATRISOME

LEFTY2 NELL1 LEFTY1 FBN1 VWF ADAM21 SLIT3 WNT9A KCP SSPOP CCN3 OTOG

1.55e-0510087112MM17056
CoexpressionAtlasratio_induced-Mesoderm_vs_StemCell_top-relative-expression-ranked_100

LEFTY2 LEFTY1 ERBB4 VWF ACKR3 FLRT3

8.33e-0799696PCBC_ratio_MESO-5_vs_SC_100
CoexpressionAtlasDevelopingGonad_e12.5_ovary_emap-28876_k-means-cluster#5_top-relative-expression-ranked_500

USP53 TENM4 RNF213 TRIM71 THSD7B

1.17e-0591695gudmap_developingGonad_e12.5_ovary_k5_500
CoexpressionAtlasMesoderm Day 5-reprogram_NA_vs_Mesoderm Day 5-reprogram_OSK-L-l-p53KD-Confounder_removed-fold2.0_adjp0.05

LEFTY2 LEFTY1 ERBB4 VWF ACKR3

1.24e-0592695PCBC_ratio_MESO-5_from-ESC_vs_MESO-5_from-OSK-L-l-p53KD_cfr-2X-p05
CoexpressionAtlasMesoderm Day 5-method_NA_vs_Mesoderm Day 5-method_episomal-Confounder_removed-fold2.0_adjp0.05

LEFTY2 LEFTY1 ERBB4 VWF

1.38e-0545694PCBC_ratio_MESO-5_from-ESC_vs_MESO-5_from-episomal_cfr-2X-p05
CoexpressionAtlasratio_induced-DefinitiveEndoderm_vs_StemCell_top-relative-expression-ranked_100

LEFTY2 LEFTY1 VWF ACKR3 FLRT3

1.77e-0599695PCBC_ratio_DE_vs_SC_100
CoexpressionAtlasEctoderm Differentiated Cells-method_mRNA_vs_Ectoderm Differentiated Cells-method_NA-Confounder_removed-fold2.0_adjp0.05

LEFTY2 LEFTY1 TMEM74 DLL1

3.07e-0555694PCBC_ratio_ECTO_from-mRNA_vs_ECTO_from-ESC_cfr-2X-p05
CoexpressionAtlasEctoderm Differentiated Cells-reprogram_OSKM-L_vs_Ectoderm Differentiated Cells-reprogram_NA-Confounder_removed-fold2.0_adjp0.05

LEFTY2 LEFTY1 TMEM74 DLL1

3.07e-0555694PCBC_ratio_ECTO_from-OSKM-L_vs_ECTO_from-ESC_cfr-2X-p05
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-5517_k-means-cluster#1_top-relative-expression-ranked_1000

FAT4 TENM4 ACKR3 FLRT3 THSD7B

4.46e-05120695gudmap_developingLowerUrinaryTract_e14.5_ urogenital sinus_1000_k1
CoexpressionAtlasEndoderm Differentiated Cells_vs_Ectoderm Differentiated Cells-Confounder_removed-fold2.0_adjp0.05

LEFTY2 USP53 OLFML2A LEFTY1 VWF TENM4 ACKR3 RNF213 ZNF80 HERC2 FGD6

4.80e-057966911PCBC_ratio_DE_vs_ECTO_cfr-2X-p05
CoexpressionAtlasDevelopingGonad_e12.5_epididymis_emap-29139_k-means-cluster#5_top-relative-expression-ranked_1000

USP53 TENM4 RNF213 TRIM71 THSD7B

8.68e-05138695gudmap_developingGonad_e12.5_epididymis_k5_1000
CoexpressionAtlasStromal Cells, BEC.MLN, gp38- CD31+, Lymph Node, avg-5

OLFML2A FAT4 VWF TNFRSF10B DLL1 S1PR1 NOTCH4 CCN3

1.13e-04456698GSM777032_500
CoexpressionAtlasStromal Cells, BEC.SLN, gp38- CD31+, Lymph Node, avg-4

OLFML2A FAT4 VWF TNFRSF10B DLL1 S1PR1 NOTCH4 CCN3

1.18e-04459698GSM777037_500
CoexpressionAtlasratio_induced-Mesoderm_vs_StemCell_top-relative-expression-ranked_1000_k-means-cluster#5

LEFTY2 LEFTY1 ERBB4 TENM4 ACKR3 KCP FLRT3 SSPOP

1.61e-04480698ratio_MESO_vs_SC_1000_K5
CoexpressionAtlasratio_induced-DefinitiveEndoderm_vs_StemCell_top-relative-expression-ranked_500_k-means-cluster#1

LEFTY2 USP53 LEFTY1 VWF TENM4 ACKR3 FLRT3

2.10e-04374697ratio_DE_vs_SC_500_K1
CoexpressionAtlasdev gonad_e12.5_F_VasAssocMesStromOvary_Sma_top-relative-expression-ranked_1000

USP53 FAT4 FBN1 TENM4 RNF34 UHRF1 RNF213 FLRT3 THSD7B S1PR1

2.40e-047976910gudmap_dev gonad_e12.5_F_VasAssocMesStromOvary_Sma_1000
CoexpressionAtlasdev gonad_e13.5_F_VascAssocMesenchStromOvary_Sma_top-relative-expression-ranked_1000

NELL1 FAT4 FBN1 TENM4 RNF34 MOB3B RNF213 THSD7B S1PR1 SP140

2.40e-047976910gudmap_dev gonad_e13.5_F_VascAssocMesenchStromOvary_Sma_1000
CoexpressionAtlasProgenitor-Cell-Biology-Consortium_induced-Mesoderm_from_inducedPluripotentialStemCells_derived from_from_fibroblast_top-relative-expression-ranked_1000

LEFTY2 LEFTY1 ERBB4 VWF TENM4 ACKR3 TMEM74 KCP TRIM71 FLRT3 THSD7B

2.72e-049696911PCBC_MESO-5_fibroblast_1000
CoexpressionAtlasProgenitor-Cell-Biology-Consortium_induced-Mesoderm_top-relative-expression-ranked_1000

LEFTY2 LEFTY1 ERBB4 VWF ACKR3 TMEM74 KCP TRIM71 FLRT3 THSD7B FGD6

2.84e-049746911PCBC_MESO-5_1000
CoexpressionAtlasECTO blastocyst_vs_ECTO cord blood-Confounder_removed-fold2.0_adjp0.05

TENM4 NGFR FLRT3 DLL1 S1PR1

3.75e-04189695PCBC_ratio_ECTO blastocyst_vs_ECTO cord blood_cfr-2X-p05
ToppCellTCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Colon_Adenocarcinoma-10|TCGA-Colorectal / Sample_Type by Project: Shred V9

FBN1 TENM4 TNFRSF8 CNTNAP1 SLIT3 NGFR S1PR1

2.79e-08193727194e7fa00a50cc4e026987b715323d125d79594e
ToppCellE18.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

OLFML2A NELL1 VWF ACKR3 DLL1 S1PR1

4.01e-071757262e54961846c65b185d9bd6e305dd81205579d890
ToppCellE18.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

OLFML2A NELL1 VWF ACKR3 DLL1 S1PR1

4.01e-07175726efa6a05f7417d46141b6e635f258c126b7a03aa1
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

USP53 NELL1 MALRD1 TENM4 PXDNL KCP

4.43e-071787264df6218b20c2f076c22346d23260964cc0d73e65
ToppCellE18.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NELL1 FBN1 VWF ACKR3 DLL1 S1PR1

6.30e-07189726d17e8467699c7ca7694a313c26111f085df5204e
ToppCell10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_arterial-C|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

VWF FGD6 S1PR1 NOTCH4 CCN3 SLC5A4

6.50e-0719072606bfb62b94b0faf467ef93d5bc5d08924c770098
ToppCellCOVID-19-kidney-AQP1+SLC14A1+EC|kidney / Disease (COVID-19 only), tissue and cell type

FAT4 FBN1 VWF S1PR1 NOTCH4 SLC5A4

6.50e-071907261519f34d31fe0817184c5865a0bc9f0cb479b1a4
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FAT4 FBN1 VWF S1PR1 NOTCH4 SLC5A4

7.34e-07194726b0c15e7e4bcf30856fb628dedd7ba82df33489f5
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW09-Neuronal-GABAergic_neurons|GW09 / Sample Type, Dataset, Time_group, and Cell type.

NELL1 ERBB4 ACKR3 CDADC1 KCP NOTCH4

8.02e-0719772621f3ef7c3c10b4e3adde431097dfdcd513c74a95
ToppCellBronchial-NucSeq-Stromal-Fibroblastic-Fibro_perichondrial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

FAT4 FBN1 TENM4 ACKR3 SLIT3 CDADC1

8.51e-07199726abd6117f8a3d7e798d8471c16d97b34aaf50fc9c
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW19-Neuronal-Interneuron|GW19 / Sample Type, Dataset, Time_group, and Cell type.

NELL1 ERBB4 ACKR3 CNTNAP1 THSD7B

1.57e-06121725b2d571f571133c281d72584fe925cebbd2317829
ToppCell368C-Fibroblasts-Fibroblast-F|368C / Donor, Lineage, Cell class and subclass (all cells)

OLFML2A FBN1 PXDNL SLIT3 WNT9A

5.62e-0615772574038192f016f95f80e0189035ee8ccc22ceb1b8
ToppCell368C-Fibroblasts-Fibroblast-F-|368C / Donor, Lineage, Cell class and subclass (all cells)

OLFML2A FBN1 PXDNL SLIT3 WNT9A

5.62e-06157725982e6ea78c7dabdb7c07c4a5fb2425d5e45b5b94
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

NELL1 ERBB4 MALRD1 TENM4 ZNF862

6.17e-0616072503b88dc7ad41c6ae443cab7e77ec666340bf432e
ToppCellPND03-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_prolif|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

VWF RNF168 USP51 ACKR3 UHRF1

6.36e-06161725f4f5d6eaa32169de699c8ff8e8ae35179c8e25c0
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

NELL1 ERBB4 MALRD1 TENM4 PXDNL

9.53e-06175725e5467dacf81f1f913b1719931cf1a7331434a7e7
ToppCellNS-moderate-d_07-13-Lymphoid-NK|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

FAT4 FBN1 NGFR TRIM63 S1PR1

9.53e-06175725f6cd24d22f62469319f9d244e3e5de527d3d4d94
ToppCellE18.5-Endothelial-Endothelial_lymphatic-Lymphatic_EC|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

OLFML2A RNF213 TNFRSF10B DLL1 FGD6

1.01e-051777258dfadd9852e0c256363471a7cfe6af120c8c51e0
ToppCellE18.5-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

OLFML2A RNF213 TNFRSF10B DLL1 FGD6

1.01e-05177725767b2af5f224d100b22bed32f86cec1cd17e8711
ToppCellE18.5-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

OLFML2A RNF213 TNFRSF10B DLL1 FGD6

1.01e-051777255ef2527e9b41e62f1724cdabaad9d8979266bb7d
ToppCellE18.5-Endothelial-Endothelial_lymphatic|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

OLFML2A RNF213 TNFRSF10B DLL1 FGD6

1.01e-05177725ae1d2fdd4f67f50c906b27ea084de058c6908aa2
ToppCellCerebellum-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Lrg1_(Lrg1)--|Cerebellum / BrainAtlas - Mouse McCarroll V32

VWF RHBDF2 KCP TNFRSF10B

1.01e-05837243aa95bf2d8ac37e648037faf3d54ebb243a4fde1
ToppCellCerebellum-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Lrg1_(Lrg1)-|Cerebellum / BrainAtlas - Mouse McCarroll V32

VWF RHBDF2 KCP TNFRSF10B

1.01e-058372470804dd63221dd5ed26068ec1b50f11875abbc50
ToppCellCerebellum-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Lrg1_(Lrg1)|Cerebellum / BrainAtlas - Mouse McCarroll V32

VWF RHBDF2 KCP TNFRSF10B

1.01e-0583724c1818411438f53aec76afead5c8caab701b95d39
ToppCellCerebellum-Endothelial-ENDOTHELIAL_STALK-Flt1_2|Cerebellum / BrainAtlas - Mouse McCarroll V32

VWF RHBDF2 KCP TNFRSF10B

1.01e-05837241e7af8aaa20b4c2a77cf2f330113db0faa9d483c
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FAT4 VWF S1PR1 NOTCH4 SLC5A4

1.03e-051787255f779a66aa42d1d8e8af17b4a08d5dcc733efd4c
ToppCellEndothelial-A-IPF_04|World / lung cells shred on cell class, cell subclass, sample id

FAT4 VWF ACKR3 S1PR1 NOTCH4

1.03e-051787252f2602b9305d55f25afa9861dd6c6347ae179337
ToppCelldroplet-Heart-HEART_(LV+RV_ONLY)-30m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWF ACKR3 FLRT3 ABLIM2 DLL1

1.12e-05181725cef034030e6b029a49ae56be37ea1fac1a5c350e
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

NELL1 ERBB4 MALRD1 TENM4 PXDNL

1.21e-05184725e8238fe58f94b4f5700ab7f343fb06ea61e899a9
ToppCell5'-GW_trimst-2-LymphNode-Mesenchymal-fibroblastic-Stromal_3_(C7+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FBN1 TENM4 SLIT3 NGFR CCN3

1.21e-051847254d4d8f3f44c67d74c57e7af7b7c158f0157b2f49
ToppCelldroplet-Lung-21m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l27|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FBN1 VWF MEX3D ABLIM2 RUFY4

1.28e-05186725c116cc9f41971622264434ebe29d18e719b0ae19
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

NELL1 ERBB4 MALRD1 PXDNL KCP

1.31e-0518772585e58a312fc325e4063a2d250666b99b8f99beb6
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

NELL1 ERBB4 MALRD1 PXDNL KCP

1.31e-0518772552b5b38bef3cc06487cf42c6fb22fb33f0c7ce2b
ToppCelldroplet-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l20-25|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FBN1 ACKR3 SLIT3 WNT9A TRIM71

1.31e-051877250d4b7da81036c2aa678654b9fe49c939d08fcd9b
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

USP53 NELL1 ERBB4 MALRD1 MOB3B

1.31e-051877257ea8731288e2a99f45e3958590ee1d76f49ae888
ToppCellTCGA-Breast-Primary_Tumor-Breast_Carcinoma-Infiltrating_Lobular_Carcinoma-6|TCGA-Breast / Sample_Type by Project: Shred V9

NGFR THSD7B DLL1 S1PR1 NOTCH4

1.35e-05188725c90669b51e1902fe7726555290c91c92a911df83
ToppCell5'-Adult-Appendix-Endothelial-blood_vessel_EC-arterial_capillary|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

VWF TNFRSF10C S1PR1 NOTCH4 CCN3

1.35e-05188725a11b12f1857953bcdbfb5f25e127f2350c39567d
ToppCell10x3'2.3-week_12-13-Mesenchymal_fibro-stroma-endosteal_fibroblast|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

OLFML2A FBN1 NGFR FLRT3 CCN3

1.38e-05189725c392491aabe8a3e90974ab2ea123bbbe5200439d
ToppCellE17.5-Endothelial-large_vessel_endothelial_cell|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

NELL1 FBN1 VWF ACKR3 S1PR1

1.38e-05189725360f09f46231a83f99d8fa0158b72a38068e1642
ToppCellPND01-Endothelial-Endothelial_blood-vessel-Macrovascular_EC|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

VWF ACKR3 DLL1 S1PR1 NOTCH4

1.38e-051897251e1afa66b32ae752c0a42b02b80f10205464569c
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

NELL1 ERBB4 MALRD1 TENM4 PXDNL

1.42e-051907253dcadabbefe0128a5f30ab51234f049ab4d870c6
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NELL1 ERBB4 MALRD1 TENM4 PXDNL

1.42e-05190725cc17ab84a9328124f146951c06be3eff9650d9fd
ToppCellEndothelial-A-Myositis-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

FAT4 FBN1 VWF S1PR1 NOTCH4

1.45e-05191725f702dfe88a9b04091dae87df61b2b4f43525f86a
ToppCelldroplet-Lung-nan-21m-Endothelial-Vein_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWF ACKR3 DLL1 S1PR1 NOTCH4

1.45e-0519172592b2faa72c184b6ae49530fd3b50848510904997
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Degenerative_Medullary_Thick_Ascending_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

USP53 NELL1 ERBB4 MALRD1 PXDNL

1.45e-05191725f631749ef1f2270133664cf5eb4cf545a8482bd3
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

NELL1 ERBB4 MALRD1 TENM4 PXDNL

1.45e-05191725963f4f2e852bbb4faf070aafb0d368297abacd3b
ToppCelldroplet-Lung-nan-21m-Endothelial-vein_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWF ACKR3 DLL1 S1PR1 NOTCH4

1.45e-05191725d0bbbf42d00165a53253c833adef65da6ec36bba
ToppCell10x5'v1-week_12-13-Mesenchymal_adipo-stroma|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

FAT4 TENM4 CNTNAP1 SLIT3 NGFR

1.53e-05193725cf2461af78f65616ce40d552ee9452295e3895ed
ToppCellkidney_cells-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

OLFML2A VWF ACKR3 DLL1 S1PR1

1.53e-05193725daefbfd3a3dd1351fbe94b9abfd807db44d56c24
ToppCell10x5'v1-week_12-13-Mesenchymal_adipo|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

FAT4 TENM4 CNTNAP1 SLIT3 NGFR

1.53e-051937256ef9007c9d18fb775d08fb20cdf954a28d54d7eb
ToppCell10x5'v1-week_12-13-Mesenchymal_adipo-stroma-adipo-CAR|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

FAT4 TENM4 CNTNAP1 SLIT3 NGFR

1.53e-05193725e4ea7ce011a80b81b841c907719aa532bed39d2e
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FAT4 VWF S1PR1 NOTCH4 SLC5A4

1.57e-05194725a429d22c8c9d0fd3bfa9f877a6364cecad68db30
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

USP53 FAT4 FBN1 ACKR3 SLIT3

1.61e-05195725f54bc4454270ff06e85596f98199372b50d0179f
ToppCellBronchial-NucSeq-Stromal-Peri/Epineurial_-NAF_epineurial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

TENM4 CDADC1 NGFR THSD7B ABLIM2

1.69e-05197725dfeb4a0eb4dfba90f4a3e6ba31e0ab0e4aba5849
ToppCellTracheal-NucSeq-Endothelial-Endothelia_vascular-VE_capillary|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

VWF ABLIM2 S1PR1 NOTCH4 SLC5A4

1.69e-0519772531bec97c3952c48031bd66a5dad16a70a61519c3
ToppCell3'-Child09-12-SmallIntestine-Endothelial-blood_vessel_EC-arterial_capillary|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

OLFML2A VWF S1PR1 NOTCH4 CCN3

1.69e-05197725947042f888335c0829d4d5daeb623973eadb3348
ToppCell(5)_Fibroblasts-(5)_Fibroblast-G|(5)_Fibroblasts / Lung cell shreds - cell class (v4) and cell subclass (v4)

USP53 OLFML2A NELL1 SLIT3 S1PR1

1.69e-05197725a21a710c824f9e5c7ef1674168d1ce5aef85bd35
ToppCellTracheal-NucSeq-Endothelial-Endothelia_vascular-VE_systemic_venous|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

VWF TNFRSF10B ABLIM2 NOTCH4 SLC5A4

1.73e-051987255c82dad416938d5c460069796d808170e7dbc8d9
ToppCellTracheal-NucSeq-Endothelial-Endothelia_vascular|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

VWF ABLIM2 S1PR1 NOTCH4 SLC5A4

1.73e-05198725f7aa809040fa9f5782b92eec1f289d690eb5c7bd
ToppCellILEUM-inflamed-(7)_CD36+_endothelial_cells|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

NELL1 VWF S1PR1 NOTCH4 CCN3

1.73e-0519872505d6558c7990ad2277db999025a073d29b273dfc
ToppCellTracheal-NucSeq-Endothelial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

VWF ABLIM2 S1PR1 NOTCH4 SLC5A4

1.73e-0519872577e31b6edeeb5ccd5cd3f080898c96bf9ab9f98d
ToppCellASK428-Endothelial|ASK428 / Donor, Lineage and Cell class of Lung cells from Dropseq

OLFML2A FAT4 VWF S1PR1 NOTCH4

1.73e-05198725d69d0ff115298596173a4278897a65007a71f5df
ToppCell10x5'v1-week_14-16-Mesenchymal_adipo-stroma|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

FBN1 TENM4 SLIT3 NGFR FLRT3

1.77e-051997259b2262edbdec89166d895ab97527e0ee5f9b6010
ToppCell10x5'v1-week_14-16-Mesenchymal_adipo|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

FBN1 TENM4 SLIT3 NGFR FLRT3

1.77e-05199725251b3643dcd8f4645b17101bd716e66f12a20e88
ToppCell10x5'v1-week_14-16-Mesenchymal_adipo-stroma-adipo-CAR|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

FBN1 TENM4 SLIT3 NGFR FLRT3

1.77e-05199725117f4f43b6c06dda553799b1063e827bce697370
ToppCellLPS_IL1RA-Endothelial-Endothelial-Gen_Cap|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

FAT4 VWF RNF213 FGD6 NOTCH4

1.81e-05200725dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCellParenchymal-10x3prime_v2-Endothelial-Endothelia_vascular-VE_systemic_arterial|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

VWF RNF34 ABLIM2 S1PR1 NOTCH4

1.81e-05200725a8b59e6fe04271fef61db911a286b5c48438bb84
ToppCellILEUM-non-inflamed-(7)_CD36+_endothelial_cells|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

NELL1 VWF S1PR1 NOTCH4 CCN3

1.81e-0520072545755a597725015dc3ee36f9166f9e82f6f9c603
ToppCellILEUM-non-inflamed-(7)_Endothelial_cell|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

NELL1 VWF S1PR1 NOTCH4 CCN3

1.81e-05200725ec92fe4eafe527d351ee73c9735e96855ac506a3
ToppCellCerebellum-Endothelial-ENDOTHELIAL_TIP-Dcn_2|Cerebellum / BrainAtlas - Mouse McCarroll V32

FBN1 WNT9A NGFR TRIM63

5.21e-0512672483f3540683b3b175b10af059ab8898c46eaccc13
ToppCellCerebellum-Endothelial-ENDOTHELIAL_TIP-Dcn_2-Dcn_2_1-Endothelial_Tip.Dcn.Nnat_(Nnat)|Cerebellum / BrainAtlas - Mouse McCarroll V32

FBN1 WNT9A NGFR TRIM63

5.21e-051267246d5075d659dac7b96e6857f8485a7d2c4105d685
ToppCellCerebellum-Endothelial-ENDOTHELIAL_TIP-Dcn_2-Dcn_2_1-Endothelial_Tip.Dcn.Nnat_(Nnat)-|Cerebellum / BrainAtlas - Mouse McCarroll V32

FBN1 WNT9A NGFR TRIM63

5.21e-05126724fd0001a0f3a0a4421f96fd21813c21cf6f01d40e
ToppCellCerebellum-Endothelial-ENDOTHELIAL_TIP-Dcn_2-Dcn_2_1|Cerebellum / BrainAtlas - Mouse McCarroll V32

FBN1 WNT9A NGFR TRIM63

5.21e-05126724f20424f9baf3c4059cd6b701761e7595400fc47c
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Igfbp6_Pltp|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

NELL1 FAT4 ERBB4 THSD7B

7.63e-051397249e9f29f92dbe65b26cc78b3a1c00778c6a701f5b
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell_prolif|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

VWF TNFRSF10C NOTCH4 SLC5A4

7.63e-05139724b07929348ec9ad95d7bce33a7deac0938227b19f
ToppCellTCGA-Endometrium-Primary_Tumor-Endometrial_Adenocarcinoma-Endometrioid-7|TCGA-Endometrium / Sample_Type by Project: Shred V9

LEFTY2 OLFML2A S1PR1 NOTCH4

8.98e-05145724ffbdadea0185e5d3b85f2868d5ec82b50cf2e2a1
ToppCellCOVID-19-kidney-Technical/muscle_(Imm)|COVID-19 / Disease (COVID-19 only), tissue and cell type

NELL1 THSD7B MDFIC2 CDH18

1.02e-041507240205318a870e091add66ee4305747dda9f51510d
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Lamp5-Lamp5_Ntn1_Npy2r|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

LEFTY2 FAT4 ERBB4 FLRT3

1.08e-041527248ff5a178a8f3550d89a003c0858820aab3773386
ToppCellfacs-Marrow-KLS-18m-Myeloid-CD4+_macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LEFTY1 MEX3D FGD6 NOTCH4

1.22e-041577245d08ff0ba9d3df9cc30f13cab2d2b395ea6f3446
ToppCellfacs-Marrow-KLS-18m-Myeloid-macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LEFTY1 MEX3D FGD6 NOTCH4

1.22e-04157724ad9c9b7dfeee3ae46e7e593c51a0407df12195b4
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NELL1 ERBB4 TENM4 MEX3D

1.28e-04159724c186bf05c61fac348cf41973827cced83fafd58a
ToppCellEntopeduncular-Endothelial-ENDOTHELIAL_STALK|Entopeduncular / BrainAtlas - Mouse McCarroll V32

VWF RHBDF2 TNFRSF10B SP140

1.31e-0416072404714d0b9bad4c11fa193ed168e2d84a4df39e2e
ToppCellTCGA-Kidney-Primary_Tumor-Renal_Cell_Carcinoma-Kidney_Clear_Cell_Renal_Carcinoma-1|TCGA-Kidney / Sample_Type by Project: Shred V9

OLFML2A VWF S1PR1 NOTCH4

1.34e-041617246cacae4a759ace763597ee394cff498dc5d96f74
ToppCelllymphoid-B_cell-pro-B|World / Lineage, cell class and subclass

WNT9A NGFR TRIM63 UHRF1

1.34e-0416172423138e579f07d5a6f20d41457cb573b4ac95a4ef
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_bronchial_vessel|Children_(3_yrs) / Lineage, Cell type, age group and donor

FAT4 VWF NOTCH4 SLC5A4

1.41e-04163724977a970b1296234c22178420294cea73506ee02f
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW16-Neuronal-GABAergic_neurons|GW16 / Sample Type, Dataset, Time_group, and Cell type.

NELL1 ERBB4 ACKR3 THSD7B

1.44e-041647244d7b2d0980fb4f47721fa2891151e2bd892ccb91
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

VWF S1PR1 NOTCH4 SLC5A4

1.48e-04165724a74751e0ec857aa974bec04ccc747c004a8f6e01
ToppCelllymphoid-B_cell-pro-B|lymphoid / Lineage, cell class and subclass

WNT9A NGFR TRIM63 UHRF1

1.48e-041657248126c2f7810fc6e09b18783aadf6434ae12b0514
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW26-Neuronal-Interneuron|GW26 / Sample Type, Dataset, Time_group, and Cell type.

ERBB4 ACKR3 MOB3B

1.53e-0464723fefabdf8d72a8f3caf78eb79d759edb475bdb2ad
ToppCellTCGA-Thryoid-Primary_Tumor-Thyroid_Papillary_Carcinoma-Classical-8|TCGA-Thryoid / Sample_Type by Project: Shred V9

CNTNAP1 SLIT3 NGFR DLL1

1.58e-0416872400646601548b0fee42ae16bfa5e93603bc7c5129
ToppCelldroplet-Thymus-nan-24m-Lymphocytic-DN_to_DP_transition,_dividing_(more_DN)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAM120B IGF1R DEAF1 MEX3D

1.58e-04168724b9db0b1e4fe54a1fe79530d15d206155a1bfac39
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1-5_VIP_KCNJ2|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LEFTY2 FAT4 ERBB4 THSD7B

1.58e-04168724237a6a6e3bd3ed0e9f24a964b939bfdad442fc19
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1-5_VIP_KCNJ2|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FAT4 ERBB4 ZNF80 THSD7B

1.62e-04169724d161dd8eb22633392b6c6466ee9eff4042464149
ToppCellfacs-Lung-Endomucin-24m-Endothelial-Vein_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWF USP51 ACKR3 S1PR1

1.62e-041697248dba7546adc6b1345933eec81fc77fc9611fae60
ToppCell356C-Endothelial_cells-Endothelial-B_(Artery)|356C / Donor, Lineage, Cell class and subclass (all cells)

VWF TMEM74 S1PR1 NOTCH4

1.62e-04169724605cc2638271803cf1d972ab3fa8f13f89666376
ToppCell356C-Endothelial_cells-Endothelial-B_(Artery)-|356C / Donor, Lineage, Cell class and subclass (all cells)

VWF TMEM74 S1PR1 NOTCH4

1.62e-04169724337be3bf485b54afad86e256cb0c4c1d0c2a9a2a
ToppCellfacs-Lung-Endomucin-24m-Endothelial-vein_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWF USP51 ACKR3 S1PR1

1.62e-04169724d2862a7ddee6d7a65d84ef9d0800ba6f4690973f
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_artery-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

LEFTY1 FAT4 VWF NOTCH4

1.69e-041717241597459c971d6befa991d59dc66b41b6a522f797
ToppCelllymphoid-B_cell-pro-B|B_cell / Lineage, cell class and subclass

WNT9A NGFR TRIM63 UHRF1

1.73e-04172724da1e2e54f442f5c2032c857c4812e9060f2053cd
ToppCellfacs-Trachea-24m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l10|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ERBB4 TNFRSF10B S1PR1 NOTCH4

1.73e-04172724c84cab89c97d647b8a256fd08e33d9102810febd
DrugParathion

OLFML2A NELL1 ZNF136 DSC1 USP51 SLIT3 NGFR UHRF1 TNFRSF10C S1PR1 NOTCH4 SP140

7.02e-068227012ctd:D010278
DrugFonofos

OLFML2A NELL1 ZNF136 DSC1 USP51 SLIT3 NGFR UHRF1 TNFRSF10C S1PR1 SP140

1.07e-057147011ctd:D004397
Drugterbufos

OLFML2A NELL1 ZNF136 DSC1 USP51 SLIT3 NGFR UHRF1 TNFRSF10C S1PR1 SP140

1.22e-057247011ctd:C012568
Diseasepulse pressure measurement

FBN1 PBRM1 MALRD1 TENM4 PXDNL SLIT3 TMEM74 UHRF1 RNF213 SSPOP FGD6 CCN3

8.43e-0513926912EFO_0005763
DiseaseNeoplasm of uncertain or unknown behavior of breast

ERBB4 PBRM1 HERC2

1.22e-0441693C0496956
DiseaseBreast adenocarcinoma

ERBB4 PBRM1 HERC2

1.22e-0441693C0858252
Diseasemesangial proliferative glomerulonephritis (biomarker_via_orthology)

FBN1 VWF

1.50e-048692DOID:4783 (biomarker_via_orthology)
Diseasedementia (is_implicated_in)

IGF1R NOTCH4

3.50e-0412692DOID:1307 (is_implicated_in)
Diseaseprogression free survival, urinary bladder cancer

ERBB4 TENM4

3.50e-0412692EFO_0004920, MONDO_0001187
DiseaseMalignant neoplasm of skin

ERBB4 IGF1R NOTCH4

3.62e-0459693C0007114
DiseaseSkin Neoplasms

ERBB4 IGF1R NOTCH4

3.62e-0459693C0037286
Diseasemood disorder

PBRM1 FLRT3

4.13e-0413692EFO_0004247
DiseaseParoxysmal atrial fibrillation

ERBB4 IGF1R VWF SLIT3

4.97e-04156694C0235480
Diseasefamilial atrial fibrillation

ERBB4 IGF1R VWF SLIT3

4.97e-04156694C3468561
DiseasePersistent atrial fibrillation

ERBB4 IGF1R VWF SLIT3

4.97e-04156694C2585653
DiseaseAtrial Fibrillation

ERBB4 IGF1R VWF SLIT3

5.47e-04160694C0004238
Diseasemigraine disorder, endometriosis

NELL1 ERBB4 FGD6

6.77e-0473693EFO_0001065, MONDO_0005277
DiseaseChild Behaviour Checklist assessment

LEFTY1 TENM4

8.05e-0418692EFO_0005661
DiseaseLewy body dementia (is_marker_for)

IGF1R NGFR

8.98e-0419692DOID:12217 (is_marker_for)
Diseasetype 1 diabetes mellitus (biomarker_via_orthology)

VWF CBL

8.98e-0419692DOID:9744 (biomarker_via_orthology)
Diseaseosteoarthritis (biomarker_via_orthology)

TNFRSF10C TNFRSF10B

1.10e-0321692DOID:8398 (biomarker_via_orthology)
Diseaseremission, hepatitis C virus infection

MALRD1 NOTCH4

1.32e-0323692EFO_0003047, EFO_0009785
Diseasecongenital diaphragmatic hernia (biomarker_via_orthology)

SLIT3 CBL

1.44e-0324692DOID:3827 (biomarker_via_orthology)
Diseasesystemic scleroderma (is_implicated_in)

FBN1 NOTCH4

1.44e-0324692DOID:418 (is_implicated_in)
Diseaseupper face morphology measurement

NELL1 CCN3 SP140

1.54e-0397693EFO_0010949
DiseaseBreast Carcinoma

ERBB4 IGF1R PBRM1 HERC2 DLL1 NOTCH4

1.62e-03538696C0678222
DiseaseMental deterioration

ERBB4 TENM4

2.10e-0329692HP_0001268
Diseaseglutamate measurement

LEFTY2 OTOG

2.10e-0329692EFO_0010487

Protein segments in the cluster

PeptideGeneStartEntry
SLASIMCCPEVAKSC

C21orf140

151

B9A014
MSIICCDSRIACGKV

ERICH6

406

Q7L0X2
SSSCVRACPSSKMEV

ERBB4

301

Q15303
DTCGITDRCSPNMCE

CNTNAP1

536

P78357
SHVCLPETCNMKGIC

ADAM21

631

Q9UKJ8
CSCPDSHTGRTCEMV

FAT4

4451

Q6V0I7
VMAKSCPSVCRCDAG

FLRT3

26

Q9NZU0
CCGDTVCVRTTMEQK

RTL10

51

Q7L3V2
GKECMCQKCSLPVSV

ABLIM2

126

Q6H8Q1
RSMIFVTKCPCDECV

CDADC1

416

Q9BWV3
VVCCPTSGPQMCSKR

DEDD

151

O75618
GTICEFCTERTCPVM

MOB3B

76

Q86TA1
EETCPMTCILGKCAV

PBRM1

1221

Q86U86
CDPEAPMTEGTRCCR

LEFTY1

251

O75610
DTCSVPICRECTMGR

TRIM71

291

Q2Q1W2
DRCVLSCPSMDLVTC

HERC2

3721

O95714
CQKMCPSTCGKRACT

IGF1R

211

P08069
CMDCAVRICGKSEPE

MEX3D

621

Q86XN8
MSAISCSCKPGLLVC

KDM5B

701

Q9UGL1
GTFVVARTVICMSCC

OR6X1

81

Q8NH79
TCKSGAVECRRMSCP

NELL1

296

Q92832
KACTRCGCVTMLKSP

MED16

796

Q9Y2X0
CPDKSDEASCVMEVC

MALRD1

1076

Q5VYJ5
LVKGTCCPVCRDRGM

PXDNL

1441

A1KZ92
QTPGCCRAECMQSSR

DCLRE1C

431

Q96SD1
MVIGTCTCHTNCPKN

CCN3

326

P48745
CAACCDDMTLSGPVR

DEAF1

281

O75398
KICELSAMTCADGPC

DLL1

361

O00548
VCINMVGSFRCECPV

FBN1

1781

P35555
CNSSDCIVVDTVMCP

ACKR3

21

P25106
CDPEAPMTEGTRCCR

LEFTY2

251

O00292
MKITSTSCICPVLVC

CDH18

1

Q13634
TVRVCDCSTPSECRM

DSC1

661

Q08554
QSSVCMPVSCTRIVC

KRTAP12-3

31

P60328
MPVSCTRIVCVAPSC

KRTAP12-3

36

P60328
VKIEPCGHLMCTSCL

CBL

391

P22681
AFIRIMSCCKCPSGD

S1PR1

321

P21453
GCTPTIVVDAMCCLR

FAM120B

36

Q96EK7
CLLMLPGTCETVCTK

MDFIC2

121

A0A1B0GVS7
PGTCETVCTKMCCPS

MDFIC2

126

A0A1B0GVS7
TSEGSDCRCKCIMRP

OLFML2A

41

Q68BL7
CHCKDGVMSCDSRAP

OTOG

866

Q6ZRI0
APGSATMKECNRCIC

SSPOP

891

A2VEC9
CVSGKMACTSERCPV

SSPOP

2971

A2VEC9
DPTCSLCTCQEGSMR

KCP

861

Q6ZWJ8
MAPECCVACSKIFGR

RUFY4

516

Q6ZNE9
DMVACVVPSECVKHC

SLC5A4

341

Q9NY91
TCVNRPGTFSCLCAM

NOTCH4

781

Q99466
TCEVPTCSMCKVFGI

TRIM63

136

Q969Q1
VPSRDADMCTSKSCI

USP53

136

Q70EK8
SCATASKVPIMECRG

SLIT3

1466

O75094
RDMKMGVLFCSSCCP

PWP1

426

Q13610
CSVGECGRPMEQSIC

RNF213

4511

Q63HN8
HKCIMTSPSLCLVCE

USP51

396

Q70EK9
CKECGEAFSCIPSMR

ZNF136

366

P52737
KTSACCPSCRCERME

VWF

2566

P04275
PGKTVMIDVCTTCRC

VWF

2591

P04275
GKIMKIPGTCCDTCE

VWF

2706

P04275
CTKCGKRMSECPICR

RNF34

346

Q969K3
CTECVGLQSMSAPCV

NGFR

86

P08138
ISPMCSCSSECIHKL

FGD6

106

Q6ZV73
CTMTRDTVCQCKEGT

TNFRSF10C

101

O14798
SPEMCRKCSRCPSGE

TNFRSF10C

121

O14798
NSSRVCECRPGMFCS

TNFRSF8

101

P28908
CECRPGMFCSTSAVN

TNFRSF8

106

P28908
NSSRTCECRPGMICA

TNFRSF8

276

P28908
CECRPGMICATSATN

TNFRSF8

281

P28908
DCMDPTCSGRGVCVR

TENM4

661

Q6N022
EEDSPEMCRKCRTGC

TNFRSF10B

146

O14763
KETAVMPCGRTESGC

RNF168

341

Q8IYW5
MAVVVCVPISTSCCE

ZNF862

1026

O60290
MRIHTGEKPCKCVEC

ZNF80

96

P51504
MACVGRTKECTIVPS

UHRF1

401

Q96T88
VRIHTGEKPCQCVMC

ZBTB17

521

Q13105
CSAGRMERCTCDEAP

WNT9A

141

O14904
IFCRMKESPGSQQCC

SP140

731

Q13342
RCMETTPSLACANKC

TYW1

406

Q9NV66
CCQKQCASTPRATEM

TMEM74

41

Q96NL1
SCVCSDGKPVSMDQC

THSD7B

1211

Q9C0I4
TCKMVDGVGVCTVCA

UBR4

1681

Q5T4S7
MDCEIKGRPCCIGTK

RHBDF2

591

Q6PJF5