Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	histone H3K4me/H3K4me2/H3K4me3 demethylase activity	KDM5A KDM5C KDM5D	1.48e-06	6	85	3	GO:0034647
GeneOntologyMolecularFunction	histone H3K4 demethylase activity	KDM5A KDM5C KDM5D	4.11e-06	8	85	3	GO:0032453
GeneOntologyMolecularFunction	histone H3 demethylase activity	KDM5A KDM5C KDM5D	2.26e-04	28	85	3	GO:0141052
GeneOntologyMolecularFunction	histone demethylase activity	KDM5A KDM5C KDM5D	3.07e-04	31	85	3	GO:0032452
GeneOntologyMolecularFunction	protein demethylase activity	KDM5A KDM5C KDM5D	3.38e-04	32	85	3	GO:0140457
GeneOntologyMolecularFunction	angiotensin receptor binding	ARRB1 AGT	7.88e-04	10	85	2	GO:0031701
GeneOntologyMolecularFunction	demethylase activity	KDM5A KDM5C KDM5D	8.69e-04	44	85	3	GO:0032451
GeneOntologyMolecularFunction	enzyme regulator activity	TGFB1 RALGAPA1 ARRB1 AFAP1L2 KDM5A STXBP5L AGT EIF2B2 TOPBP1 DOCK7 KIAA1755 ITPRIP DENND1A ARHGAP21 VEGFA	8.77e-04	1418	85	15	GO:0030234
GeneOntologyMolecularFunction	myosin II binding	SHROOM1 STXBP5L	1.35e-03	13	85	2	GO:0045159
GeneOntologyMolecularFunction	nucleoside-triphosphatase regulator activity	RALGAPA1 ARRB1 STXBP5L EIF2B2 DOCK7 KIAA1755 DENND1A ARHGAP21	1.42e-03	507	85	8	GO:0060589
GeneOntologyMolecularFunction	GTPase regulator activity	RALGAPA1 ARRB1 STXBP5L EIF2B2 DOCK7 KIAA1755 DENND1A ARHGAP21	1.42e-03	507	85	8	GO:0030695
GeneOntologyBiologicalProcess	regulation of morphogenesis of an epithelium	TGFB1 SFRP1 PIK3CD AGT VEGFA	1.74e-05	76	87	5	GO:1905330
GeneOntologyBiologicalProcess	female gonad development	SFRP1 ARRB1 GRK2 AGT EIF2B2 VEGFA	2.60e-05	138	87	6	GO:0008585
GeneOntologyBiologicalProcess	positive regulation of morphogenesis of an epithelium	TGFB1 PIK3CD AGT VEGFA	2.92e-05	42	87	4	GO:1905332
GeneOntologyBiologicalProcess	development of primary female sexual characteristics	SFRP1 ARRB1 GRK2 AGT EIF2B2 VEGFA	3.06e-05	142	87	6	GO:0046545
GeneOntologyBiologicalProcess	response to ionizing radiation	TGFB1 TLK2 SFRP1 RAD54B TOPBP1 BRAT1	4.32e-05	151	87	6	GO:0010212
GeneOntologyBiologicalProcess	female sex differentiation	SFRP1 ARRB1 GRK2 AGT EIF2B2 VEGFA	5.37e-05	157	87	6	GO:0046660
GeneOntologyBiologicalProcess	glial cell differentiation	TGFB1 GRK2 AGT ASPA EIF2B2 LAMB2 AFDN F2	6.34e-05	321	87	8	GO:0010001
GeneOntologyBiologicalProcess	positive regulation of branching involved in ureteric bud morphogenesis	TGFB1 AGT VEGFA	1.05e-04	22	87	3	GO:0090190
GeneOntologyBiologicalProcess	extracellular matrix assembly	TGFB1 AGT LAMB2 ANTXR1	1.13e-04	59	87	4	GO:0085029
GeneOntologyBiologicalProcess	regulation of branching involved in ureteric bud morphogenesis	TGFB1 AGT VEGFA	1.38e-04	24	87	3	GO:0090189
GeneOntologyBiologicalProcess	miRNA metabolic process	TGFB1 XPO5 AGT TENT2 VEGFA	1.49e-04	119	87	5	GO:0010586
GeneOntologyBiologicalProcess	regulation of morphogenesis of a branching structure	TGFB1 SFRP1 AGT VEGFA	1.64e-04	65	87	4	GO:0060688
GeneOntologyBiologicalProcess	positive regulation of receptor signaling pathway via STAT	TGFB1 AGT F2 VEGFA	1.64e-04	65	87	4	GO:1904894
GeneOntologyBiologicalProcess	cardiac vascular smooth muscle cell development	PBRM1 VEGFA	1.74e-04	5	87	2	GO:0060948
GeneOntologyBiologicalProcess	hematopoietic progenitor cell differentiation	TGFB1 SFRP1 DOCK7 KCP TENT2 VEGFA	1.87e-04	197	87	6	GO:0002244
GeneOntologyBiologicalProcess	regulation of extracellular matrix assembly	TGFB1 AGT ANTXR1	2.45e-04	29	87	3	GO:1901201
GeneOntologyBiologicalProcess	positive regulation of cell growth	SFRP1 EIF2B2 AFDN F2 BRAT1 VEGFA	2.85e-04	213	87	6	GO:0030307
GeneOntologyBiologicalProcess	positive regulation of epidermal growth factor receptor signaling pathway	TGFB1 AFAP1L2 AGT	2.99e-04	31	87	3	GO:0045742
GeneOntologyBiologicalProcess	regulation of androgen receptor signaling pathway	SFRP1 KDM5D PIAS2	2.99e-04	31	87	3	GO:0060765
GeneOntologyBiologicalProcess	regulation of muscle cell apoptotic process	LIFR ARRB1 GRK2 AGT ACOT1	3.28e-04	141	87	5	GO:0010660
GeneOntologyBiologicalProcess	positive regulation of ERBB signaling pathway	TGFB1 AFAP1L2 AGT	3.61e-04	33	87	3	GO:1901186
GeneOntologyBiologicalProcess	negative regulation of miRNA metabolic process	TGFB1 TENT2 VEGFA	3.95e-04	34	87	3	GO:2000629
GeneOntologyBiologicalProcess	positive regulation of endothelial cell migration	TGFB1 SPARC PIK3CD AGT VEGFA	4.09e-04	148	87	5	GO:0010595
GeneOntologyBiologicalProcess	muscle cell apoptotic process	LIFR ARRB1 GRK2 AGT ACOT1	4.35e-04	150	87	5	GO:0010657
GeneOntologyBiologicalProcess	regulation of extracellular matrix organization	TGFB1 AGT LAMB2 ANTXR1	4.41e-04	84	87	4	GO:1903053
GeneOntologyBiologicalProcess	cell morphogenesis	TGFB1 LIFR VLDLR SPARC SHROOM1 EIF2B2 DOCK7 LAMA3 KIAA1755 LAMB2 AFDN F2 PIAS2 VEGFA	4.50e-04	1194	87	14	GO:0000902
GeneOntologyBiologicalProcess	follicle-stimulating hormone signaling pathway	ARRB1 GRK2	4.84e-04	8	87	2	GO:0042699
GeneOntologyBiologicalProcess	gliogenesis	TGFB1 GRK2 AGT ASPA EIF2B2 LAMB2 AFDN F2	5.01e-04	435	87	8	GO:0042063
GeneOntologyBiologicalProcess	blood vessel remodeling	TGFB1 PBRM1 AGT VEGFA	5.03e-04	87	87	4	GO:0001974
GeneOntologyBiologicalProcess	ovarian follicle development	ARRB1 GRK2 EIF2B2 VEGFA	5.03e-04	87	87	4	GO:0001541
GeneOntologyBiologicalProcess	glial cell development	TGFB1 AGT ASPA EIF2B2 LAMB2	5.36e-04	157	87	5	GO:0021782
GeneOntologyBiologicalProcess	regulation of kidney development	TGFB1 AGT VEGFA	5.50e-04	38	87	3	GO:0090183
GeneOntologyBiologicalProcess	positive regulation of growth	SFRP1 AGT EIF2B2 AFDN F2 BRAT1 VEGFA	5.77e-04	339	87	7	GO:0045927
GeneOntologyBiologicalProcess	kidney epithelium development	TGFB1 SFRP1 AGT LAMB2 VEGFA	6.18e-04	162	87	5	GO:0072073
GeneOntologyBiologicalProcess	regulation of epithelial tube formation	PIK3CD VEGFA	6.21e-04	9	87	2	GO:1905276
GeneOntologyBiologicalProcess	positive regulation of epithelial tube formation	PIK3CD VEGFA	6.21e-04	9	87	2	GO:1905278
GeneOntologyCellularComponent	laminin-3 complex	LAMA3 LAMB2	5.36e-05	3	89	2	GO:0005608
Domain	Lys_sp_deMease-like_dom	KDM5A KDM5C KDM5D	3.76e-07	4	86	3	IPR013637
Domain	PLU-1	KDM5A KDM5C KDM5D	3.76e-07	4	86	3	PF08429
Domain	zf-C5HC2	KDM5A KDM5C KDM5D	9.36e-07	5	86	3	PF02928
Domain	Znf_C5HC2	KDM5A KDM5C KDM5D	9.36e-07	5	86	3	IPR004198
Domain	JmjN	KDM5A KDM5C KDM5D	1.11e-05	10	86	3	SM00545
Domain	JMJN	KDM5A KDM5C KDM5D	1.11e-05	10	86	3	PS51183
Domain	JmjN	KDM5A KDM5C KDM5D	1.11e-05	10	86	3	PF02375
Domain	JmjN	KDM5A KDM5C KDM5D	1.11e-05	10	86	3	IPR003349
Domain	-	KDM5A KDM5C KDM5D	4.12e-05	15	86	3	1.10.150.60
Domain	BRIGHT	KDM5A KDM5C KDM5D	4.12e-05	15	86	3	SM00501
Domain	ARID_dom	KDM5A KDM5C KDM5D	4.12e-05	15	86	3	IPR001606
Domain	ARID	KDM5A KDM5C KDM5D	4.12e-05	15	86	3	PS51011
Domain	ARID	KDM5A KDM5C KDM5D	4.12e-05	15	86	3	PF01388
Domain	JmjC	KDM5A KDM5C KDM5D	1.78e-04	24	86	3	PF02373
Domain	BAAT_C	ACOT1 ACOT6	2.08e-04	5	86	2	IPR014940
Domain	BAAT_C	ACOT1 ACOT6	2.08e-04	5	86	2	PF08840
Domain	JMJC	KDM5A KDM5C KDM5D	4.25e-04	32	86	3	PS51184
Domain	JmjC_dom	KDM5A KDM5C KDM5D	4.25e-04	32	86	3	IPR003347
Domain	JmjC	KDM5A KDM5C KDM5D	4.65e-04	33	86	3	SM00558
Domain	Unchr_dom_Cys-rich	KCP MUC5AC	1.58e-03	13	86	2	IPR014853
Domain	C8	KCP MUC5AC	1.58e-03	13	86	2	SM00832
Domain	TIL_dom	KCP MUC5AC	1.84e-03	14	86	2	IPR002919
Domain	Glyco_hormone_CN	TSHB MUC5AC	2.12e-03	15	86	2	IPR006208
Domain	Cys_knot	TSHB MUC5AC	2.12e-03	15	86	2	PF00007
Domain	VWD	KCP MUC5AC	2.41e-03	16	86	2	SM00216
Domain	VWF_type-D	KCP MUC5AC	2.41e-03	16	86	2	IPR001846
Domain	Laminin_N	LAMA3 LAMB2	2.41e-03	16	86	2	IPR008211
Domain	LAMININ_NTER	LAMA3 LAMB2	2.41e-03	16	86	2	PS51117
Domain	VWFD	KCP MUC5AC	2.41e-03	16	86	2	PS51233
Domain	Laminin_N	LAMA3 LAMB2	2.41e-03	16	86	2	PF00055
Domain	VWD	KCP MUC5AC	2.41e-03	16	86	2	PF00094
Domain	LamNT	LAMA3 LAMB2	2.41e-03	16	86	2	SM00136
Domain	Zinc_finger_PHD-type_CS	KDM5A KDM5C KDM5D	3.35e-03	65	86	3	IPR019786
Domain	VWC_out	KCP MUC5AC	3.41e-03	19	86	2	SM00215
Domain	-	TGFB1 TSHB VEGFA	3.65e-03	67	86	3	2.10.90.10
Domain	Cystine-knot_cytokine	TGFB1 TSHB VEGFA	3.65e-03	67	86	3	IPR029034
Domain	BRCT	SLF1 TOPBP1	4.56e-03	22	86	2	SM00292
Domain	-	SLF1 TOPBP1	4.98e-03	23	86	2	3.40.50.10190
Domain	PHD	KDM5A KDM5C KDM5D	5.01e-03	75	86	3	PF00628
Pubmed	Novel JARID1C/SMCX mutations in patients with X-linked mental retardation.	KDM5A KDM5C KDM5D	6.47e-08	4	89	3	16541399
Pubmed	Molecular interactions and functional interference between vitronectin and transforming growth factor-beta.	TGFB1 F2 VEGFA	8.99e-07	8	89	3	11796824
Pubmed	Dynamic patterns of histone H3 lysine 4 methyltransferases and demethylases during mouse preimplantation development.	KDM5A KDM5C KDM5D	4.55e-06	13	89	3	24619213
Pubmed	Immunohistochemical analysis of TGF-β1 and VEGF in gingival and periodontal tissues: a role of these biomarkers in the pathogenesis of scleroderma and periodontal disease.	TGFB1 VEGFA	6.48e-06	2	89	2	22692760
Pubmed	SPARC is a key mediator of TGF-β-induced renal cancer metastasis.	TGFB1 SPARC	6.48e-06	2	89	2	32780451
Pubmed	SPARC (BM-40, osteonectin) inhibits the mitogenic effect of vascular endothelial growth factor on microvascular endothelial cells.	SPARC VEGFA	6.48e-06	2	89	2	9792673
Pubmed	The Effects of the Transforming Growth Factor-β1 (TGF-β1) Signaling Pathway on Cell Proliferation and Cell Migration are Mediated by Ubiquitin Specific Protease 4 (USP4) in Hypertrophic Scar Tissue and Primary Fibroblast Cultures.	TGFB1 USP4	6.48e-06	2	89	2	32308208
Pubmed	Genetic control of VEGF and TGF-beta1 gene polymorphisms in childhood urinary tract infection and vesicoureteral reflux.	TGFB1 VEGFA	6.48e-06	2	89	2	17597658
Pubmed	GRK2 and beta-arrestin 1 as negative regulators of thyrotropin receptor-stimulated response.	ARRB1 GRK2	6.48e-06	2	89	2	8885248
Pubmed	Functional polymorphisms in transforming growth factor-beta-1 (TGFbeta-1) and vascular endothelial growth factor (VEGF) genes modify risk of renal parenchymal scarring following childhood urinary tract infection.	TGFB1 VEGFA	6.48e-06	2	89	2	19861314
Pubmed	Abrogation of TGF-beta by antisense oligonucleotides modulates expression of VEGF and increases angiogenic potential in isolated fibroblasts from radiated skin.	TGFB1 VEGFA	6.48e-06	2	89	2	18813854
Pubmed	[Expression Level of TGFβ1 and VEGF Gene in Acute Myeloid Patients and Its Clinical Prognostic Value].	TGFB1 VEGFA	6.48e-06	2	89	2	32027265
Pubmed	Contraction-dependent TGF-β1 activation is required for thrombin-induced remodeling in human airway smooth muscle cells.	TGFB1 F2	6.48e-06	2	89	2	29428600
Pubmed	TGFβ1 induces in-vitro and ex-vivo angiogenesis through VEGF production in human ovarian follicular fluid-derived granulosa cells during in-vitro fertilization cycle.	TGFB1 VEGFA	6.48e-06	2	89	2	33812317
Pubmed	The relationship between transforming growth factor-beta1, vascular endothelial growth factor, nitric oxide and Hashimoto's thyroiditis.	TGFB1 VEGFA	6.48e-06	2	89	2	19028605
Pubmed	Mouse H-Y encoding Smcy gene and its X chromosomal homolog Smcx.	KDM5C KDM5D	6.48e-06	2	89	2	10441747
Pubmed	Inefficient purifying selection: the mammalian Y chromosome in the rodent genus Mus.	KDM5C KDM5D	6.48e-06	2	89	2	16416087
Pubmed	SPARC acts as a mediator of TGF-β1 in promoting epithelial-to-mesenchymal transition in A549 and H1299 lung cancer cells.	TGFB1 SPARC	6.48e-06	2	89	2	30346081
Pubmed	The VEGF -634G>C promoter polymorphism is associated with risk of gastric cancer.	TGFB1 VEGFA	6.48e-06	2	89	2	19835575
Pubmed	Mutations of histone demethylase genes encoded by X and Y chromosomes, Kdm5c and Kdm5d, lead to noncompaction cardiomyopathy in mice.	KDM5C KDM5D	6.48e-06	2	89	2	32081420
Pubmed	VEGF -460 genotype plays an important role in progression to chronic kidney disease stage 5.	TGFB1 VEGFA	6.48e-06	2	89	2	16046504
Pubmed	Losartan slows pancreatic tumor progression and extends survival of SPARC-null mice by abrogating aberrant TGFβ activation.	TGFB1 SPARC	6.48e-06	2	89	2	22348081
Pubmed	Platelet VEGF and serum TGF-β1 levels predict chemotherapy response in non-small cell lung cancer patients.	TGFB1 VEGFA	6.48e-06	2	89	2	25820820
Pubmed	SPARC regulates TGF-beta1-dependent signaling in primary glomerular mesangial cells.	TGFB1 SPARC	6.48e-06	2	89	2	15034927
Pubmed	Inhibition of VEGF blocks TGF-beta1 production through a PI3K/Akt signalling pathway.	TGFB1 VEGFA	6.48e-06	2	89	2	18057050
Pubmed	The Relationship between VEGFA and TGFB1 Polymorphisms and Target Lesion Revascularization after Elective Percutaneous Coronary Intervention.	TGFB1 VEGFA	6.48e-06	2	89	2	28811677
Pubmed	TGF-β/VEGF-A Genetic Variants Interplay in Genetic Susceptibility to Non-Melanocytic Skin Cancer.	TGFB1 VEGFA	6.48e-06	2	89	2	35886018
Pubmed	Reduced angiotensinogen expression attenuates renal interstitial fibrosis in obstructive nephropathy in mice.	TGFB1 AGT	6.48e-06	2	89	2	9884332
Pubmed	SPARC is expressed in scars of the Tenon's capsule and mediates scarring properties of human Tenon's fibroblasts in vitro.	TGFB1 SPARC	6.48e-06	2	89	2	21264231
Pubmed	TGF-β1 induces VEGF expression in human granulosa-lutein cells: a potential mechanism for the pathogenesis of ovarian hyperstimulation syndrome.	TGFB1 VEGFA	6.48e-06	2	89	2	32152452
Pubmed	The role of thrombin in the neo-vascularization of malignant gliomas: an intrinsic modulator for the up-regulation of vascular endothelial growth factor.	F2 VEGFA	6.48e-06	2	89	2	11956584
Pubmed	The Relationship between VEGF and AGT Gene Single Nucleotide Polymorphisms and Susceptibility to Renal and Bladder Cancers.	AGT VEGFA	6.48e-06	2	89	2	37455529
Pubmed	TGF-β1-VEGF-A pathway induces neoangiogenesis with peritoneal fibrosis in patients undergoing peritoneal dialysis.	TGFB1 VEGFA	6.48e-06	2	89	2	28978530
Pubmed	NLRC5 regulates TGF-β1-induced proliferation and activation of hepatic stellate cells during hepatic fibrosis.	TGFB1 NLRC5	6.48e-06	2	89	2	26592197
Pubmed	Effect of budesonide on TGF-beta1-enhanced VEGF production by lung fibroblasts.	TGFB1 VEGFA	6.48e-06	2	89	2	20359293
Pubmed	Dual action of TGF-β induces vascular growth in vivo through recruitment of angiogenic VEGF-producing hematopoietic effector cells.	TGFB1 VEGFA	6.48e-06	2	89	2	22581517
Pubmed	High serum levels of vascular endothelial growth factor-A and transforming growth factor-β1 before neoadjuvant chemoradiotherapy predict poor outcomes in patients with esophageal squamous cell carcinoma receiving combined modality therapy.	TGFB1 VEGFA	6.48e-06	2	89	2	24623035
Pubmed	Protein and mRNA expression levels of VEGF-A and TGF-beta1 in different types of human coronary atherosclerotic lesions.	TGFB1 VEGFA	6.48e-06	2	89	2	15754021
Pubmed	[Relation of advanced oxidation protein products with VEGF and TGF-β1 in colon cancer cells exposed to intermittent hypoxia].	TGFB1 VEGFA	6.48e-06	2	89	2	21515455
Pubmed	A mouse Y chromosome gene encoded by a region essential for spermatogenesis and expression of male-specific minor histocompatibility antigens.	KDM5C KDM5D	6.48e-06	2	89	2	7524912
Pubmed	Cyclic mechanical strain increases production of regulators of bone healing in cultured murine osteoblasts.	TGFB1 VEGFA	6.48e-06	2	89	2	17324777
Pubmed	Is endometrial polyp formation associated with increased expression of vascular endothelial growth factor and transforming growth factor-beta1?	TGFB1 VEGFA	6.48e-06	2	89	2	21726930
Pubmed	[Effect of myocardial revascularization on dynamics of factors of angiogenesis in patients with ischemic heart disease].	TGFB1 VEGFA	6.48e-06	2	89	2	20038274
Pubmed	Evaluation of transforming growth factor and vascular endothelial growth factor polymorphisms in Taiwan Chinese patients with pterygium.	TGFB1 VEGFA	6.48e-06	2	89	2	18203080
Pubmed	Different roles for TGF-beta and VEGF in the pathogenesis of the cardinal features of diabetic nephropathy.	TGFB1 VEGFA	6.48e-06	2	89	2	18842317
Pubmed	Small interfering RNA inhibition of SPARC attenuates the profibrotic effect of transforming growth factor beta1 in cultured normal human fibroblasts.	TGFB1 SPARC	6.48e-06	2	89	2	15641096
Pubmed	Effects of VEGF on phenotypic severity in children with hereditary hemorrhagic telangiectasia.	TGFB1 VEGFA	6.48e-06	2	89	2	19636272
Pubmed	SPARC-induced increase in glioma matrix and decrease in vascularity are associated with reduced VEGF expression and secretion.	SPARC VEGFA	6.48e-06	2	89	2	18350569
Pubmed	Upregulation of transforming growth factor-beta1 and vascular endothelial growth factor in cultured keloid fibroblasts: relevance to angiogenic activity.	TGFB1 VEGFA	6.48e-06	2	89	2	16184401
Pubmed	Decreased serum levels of the angiogenic factors VEGF and TGF-β1 in Alzheimer's disease and amnestic mild cognitive impairment.	TGFB1 VEGFA	6.48e-06	2	89	2	23827227
Pubmed	Polymorphisms of TGFB1 and VEGF genes and survival of patients with gastric cancer.	TGFB1 VEGFA	6.48e-06	2	89	2	19566948
Pubmed	Thrombin induces increased expression and secretion of VEGF from human FS4 fibroblasts, DU145 prostate cells and CHRF megakaryocytes.	F2 VEGFA	6.48e-06	2	89	2	11686329
Pubmed	Role of afadin in vascular endothelial growth factor- and sphingosine 1-phosphate-induced angiogenesis.	AFDN VEGFA	6.48e-06	2	89	2	20413783
Pubmed	TGF-beta1 and VEGF after fresh frozen bone allograft insertion in oral-maxillo-facial surgery.	TGFB1 VEGFA	6.48e-06	2	89	2	20183799
Pubmed	Serum cytokines in follicular lymphoma. Correlation of TGF-β and VEGF with survival.	TGFB1 VEGFA	6.48e-06	2	89	2	19582455
Pubmed	Prognostic value of tgfb1 protein in endometrioid adenocarcinoma.	TGFB1 VEGFA	6.48e-06	2	89	2	23176363
Pubmed	VEGF and TGF-beta are required for the maintenance of the choroid plexus and ependyma.	TGFB1 VEGFA	6.48e-06	2	89	2	18268040
Pubmed	The Clinical Research of Serum VEGF, TGF-β1, and Endostatin in Non-small Cell Lung Cancer.	TGFB1 VEGFA	6.48e-06	2	89	2	25548002
Pubmed	The roles of transforming growth factor-β₁ and vascular endothelial growth factor in the tracheal granulation formation.	TGFB1 VEGFA	6.48e-06	2	89	2	21056681
Pubmed	Dynamic biological changes in fibroblasts during hypertrophic scar formation and regression.	TGFB1 VEGFA	6.48e-06	2	89	2	24802644
Pubmed	Circulating TGF-β1 and VEGF and risk of cancer among liver transplant recipients.	TGFB1 VEGFA	6.48e-06	2	89	2	25919050
Pubmed	Effects of transforming growth factor-beta1 and vascular endothelial growth factor 165 gene transfer on Achilles tendon healing.	TGFB1 VEGFA	6.48e-06	2	89	2	19389474
Pubmed	VEGF, a prosurvival factor, acts in concert with TGF-beta1 to induce endothelial cell apoptosis.	TGFB1 VEGFA	6.48e-06	2	89	2	17088559
Pubmed	Analysis of mutation rates in the SMCY/SMCX genes shows that mammalian evolution is male driven.	KDM5C KDM5D	6.48e-06	2	89	2	9060413
Pubmed	Can serial monitoring of serum Vascular Endothelial Growth Factor (VEGF), Nitric Oxide (NO), and Angiotensin II (ANGII) levels have predictive role during Bevacizumab treatment?	AGT VEGFA	6.48e-06	2	89	2	24632679
Pubmed	Pro-fibrotic polymorphisms predictive of advanced liver fibrosis in the severely obese.	TGFB1 AGT	6.48e-06	2	89	2	14642613
Pubmed	SPARC Is Highly Expressed in Young Skin and Promotes Extracellular Matrix Integrity in Fibroblasts via the TGF-β Signaling Pathway.	TGFB1 SPARC	6.48e-06	2	89	2	37569556
Pubmed	Critical role of histone demethylase RBP2 in human gastric cancer angiogenesis.	KDM5A VEGFA	6.48e-06	2	89	2	24716659
Pubmed	Vascular endothelial growth factor is induced in response to transforming growth factor-beta in fibroblastic and epithelial cells.	TGFB1 VEGFA	6.48e-06	2	89	2	8119973
Pubmed	Slow binding kinetics of secreted protein, acidic, rich in cysteine-VEGF interaction limit VEGF activation of VEGF receptor 2 and attenuate angiogenesis.	SPARC VEGFA	6.48e-06	2	89	2	25921830
Pubmed	[Role of TGFβ1 and VEGF-А gene polymorphisms in development of chronic obliterating diseases of lower-limb arteries].	TGFB1 VEGFA	6.48e-06	2	89	2	30531766
Pubmed	Vascular endothelial growth factor A, secreted in response to transforming growth factor-β1 under hypoxic conditions, induces autocrine effects on migration of prostate cancer cells.	TGFB1 VEGFA	6.48e-06	2	89	2	22705563
Pubmed	Intragraft messenger RNA expression of angiotensinogen: relationship with transforming growth factor beta-1 and chronic allograft nephropathy in kidney transplant patients.	TGFB1 AGT	6.48e-06	2	89	2	12352892
Pubmed	Knockdown of NLRC5 inhibits renal fibroblast activation via modulating TGF-β1/Smad signaling pathway.	TGFB1 NLRC5	1.94e-05	3	89	2	29608899
Pubmed	β-arrestin1 mediates metastatic growth of breast cancer cells by facilitating HIF-1-dependent VEGF expression.	ARRB1 VEGFA	1.94e-05	3	89	2	21685944
Pubmed	Urinary fibrogenic cytokines ET-1 and TGF-β1 are associated with urinary angiotensinogen levels in obese children.	TGFB1 AGT	1.94e-05	3	89	2	26482255
Pubmed	Secreted protein acidic and rich in cysteine (SPARC) suppresses angiogenesis by down-regulating the expression of VEGF and MMP-7 in gastric cancer.	SPARC VEGFA	1.94e-05	3	89	2	22957090
Pubmed	Renin-angiotensin system transgenic mouse model recapitulates pathophysiology similar to human preeclampsia with renal injury that may be mediated through VEGF.	AGT VEGFA	1.94e-05	3	89	2	27927648
Pubmed	Patients with encapsulating peritoneal sclerosis have increased peritoneal expression of connective tissue growth factor (CCN2), transforming growth factor-β1, and vascular endothelial growth factor.	TGFB1 VEGFA	1.94e-05	3	89	2	25384022
Pubmed	Loss of SPARC in mouse skeletal muscle causes myofiber atrophy.	TGFB1 SPARC	1.94e-05	3	89	2	23424163
Pubmed	Retinal lipid and glucose metabolism dictates angiogenesis through the lipid sensor Ffar1.	VLDLR VEGFA	1.94e-05	3	89	2	26974308
Pubmed	NLRC5 promotes cell proliferation via regulating the AKT/VEGF-A signaling pathway in hepatocellular carcinoma.	NLRC5 VEGFA	1.94e-05	3	89	2	27338800
Pubmed	Inhibition of lncRNA-PAX8-AS1-N directly associated with VEGF/TGF-β1/8-OhdG enhances podocyte apoptosis in diabetic nephropathy.	TGFB1 VEGFA	1.94e-05	3	89	2	32633379
Pubmed	RBP2 belongs to a family of demethylases, specific for tri-and dimethylated lysine 4 on histone 3.	KDM5A KDM5C	1.94e-05	3	89	2	17320161
Pubmed	KDM5 family of demethylases promotes CD44-mediated chemoresistance in pancreatic adenocarcinomas.	KDM5A KDM5C	1.94e-05	3	89	2	37880235
Pubmed	β-Arrestin 1 and 2 and G protein-coupled receptor kinase 2 expression in pituitary adenomas: role in the regulation of response to somatostatin analogue treatment in patients with acromegaly.	ARRB1 GRK2	1.94e-05	3	89	2	24169548
Pubmed	USP25 inhibits renal fibrosis by regulating TGFβ-SMAD signaling pathway in Ang II-induced hypertensive mice.	TGFB1 AGT	1.94e-05	3	89	2	37059312
Pubmed	Involvement of pro-inflammatory cytokines and growth factors in the pathogenesis of Dupuytren's contracture: a novel target for a possible future therapeutic strategy?	TGFB1 VEGFA	1.94e-05	3	89	2	26201022
Pubmed	Genetic polymorphisms located in TGFB1, AGTR1, and VEGFA genes are associated to chronic renal allograft dysfunction.	TGFB1 VEGFA	1.94e-05	3	89	2	22433249
Pubmed	Angiotensin II increases glomerular permeability by β-arrestin mediated nephrin endocytosis.	ARRB1 AGT	1.94e-05	3	89	2	28004760
Pubmed	Angiotensin II induces connective tissue growth factor expression in human hepatic stellate cells by a transforming growth factor β-independent mechanism.	TGFB1 AGT	1.94e-05	3	89	2	28798388
Pubmed	Astrocytic thrombin-evoked VEGF release is dependent on p44/42 MAPKs and PAR1.	F2 VEGFA	1.94e-05	3	89	2	30606478
Pubmed	G protein-coupled receptor kinase and beta-arrestin-mediated desensitization of the angiotensin II type 1A receptor elucidated by diacylglycerol dynamics.	ARRB1 GRK2	1.94e-05	3	89	2	17008309
Pubmed	Histone demethylase KDM5 regulates cardiomyocyte maturation by promoting fatty acid oxidation, oxidative phosphorylation, and myofibrillar organization.	KDM5A KDM5C	1.94e-05	3	89	2	38230606
Pubmed	The novel circFKBP8/miR-432-5p/E2F7 cascade functions as a regulatory network in breast cancer.	E2F7 FKBP8	1.94e-05	3	89	2	39192374
Pubmed	Hyaluronic acid modulates gene expression of connective tissue growth factor (CTGF), transforming growth factor-beta1 (TGF-beta1), and vascular endothelial growth factor (VEGF) in human fibroblast-like synovial cells from advanced-stage osteoarthritis in vitro.	TGFB1 VEGFA	1.94e-05	3	89	2	19890996
Pubmed	Relationship between RSUME and HIF-1α/VEGF-A with invasion of pituitary adenoma.	RWDD3 VEGFA	1.94e-05	3	89	2	27989771
Pubmed	Suppression of the production of transforming growth factor β1, interleukin-10, and vascular endothelial growth factor in the B16F10 cells by Ganoderma lucidum polysaccharides.	TGFB1 VEGFA	1.94e-05	3	89	2	24673200
Pubmed	Correlation between SPARC, TGFβ1, Endoglin and angiogenesis mechanism in lung cancer.	TGFB1 SPARC	1.94e-05	3	89	2	30574760
Pubmed	Human pregnancy specific beta-1-glycoprotein 1 (PSG1) has a potential role in placental vascular morphogenesis.	TGFB1 VEGFA	1.94e-05	3	89	2	20335639
Interaction	SPATA1 interactions	TLK2 KDM5C UBR4 SPATA1	9.76e-06	31	88	4	int:SPATA1
Cytoband	Ensembl 112 genes in cytogenetic band chr14q24	EIF2B2 MAP3K9 ACOT1 ACOT6	6.39e-04	200	89	4	chr14q24
Cytoband	14q24.3	EIF2B2 ACOT1 ACOT6	8.06e-04	93	89	3	14q24.3
Cytoband	Xp21.3	DCAF8L1 DCAF8L2	1.46e-03	29	89	2	Xp21.3
Cytoband	3p21	PBRM1 LAMB2	1.89e-03	33	89	2	3p21
Cytoband	18q21.1	HDHD2 PIAS2	2.50e-03	38	89	2	18q21.1
Cytoband	8q22.1	RAD54B NDUFAF6	2.76e-03	40	89	2	8q22.1
Cytoband	Ensembl 112 genes in cytogenetic band chr3p21	PBRM1 LAMB2 USP4 CDHR4	3.40e-03	316	89	4	chr3p21
GeneFamily	AT-rich interaction domain containing	KDM5A KDM5C KDM5D	1.54e-05	15	60	3	418
GeneFamily	PHD finger proteins\|Lysine demethylases	KDM5A KDM5C KDM5D	6.69e-05	24	60	3	485
GeneFamily	Acyl-CoA thioesterases	ACOT1 ACOT6	4.79e-04	10	60	2	41
GeneFamily	Laminin subunits	LAMA3 LAMB2	7.00e-04	12	60	2	626
GeneFamily	Endogenous ligands	TGFB1 AGT LRRC4B TSHB F2	1.13e-03	237	60	5	542
GeneFamily	General transcription factors\|Xeroderma pigmentosum complementation groups\|DNA helicases\|ERCC excision repair associated	GTF2H3 BRF1	3.09e-03	25	60	2	565
GeneFamily	PHD finger proteins	KDM5A KDM5C KDM5D	3.33e-03	90	60	3	88
GeneFamily	Complement system\|Sushi domain containing	C1R C7	6.35e-03	36	60	2	492
Coexpression	GSE32986_UNSTIM_VS_GMCSF_AND_CURDLAN_HIGHDOSE_STIM_DC_UP	VLDLR XPO5 MRPL37 RAD54B TOPBP1 E2F7 SIAH2	5.10e-06	200	88	7	M8608
ToppCell	10x3'2.3-week_17-19-Mesenchymal_fibro-stroma-arteriolar_fibroblast\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	SFRP1 ASPA KIAA1755 LAMB2 ANTXR1 C1R LRRC4B	1.51e-07	199	89	7	95d95e9b7bd3933188998ae94986213eb0f1e5ea
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-stromal_related\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SPARC SFRP1 AGT C1R C7 SPATA1	1.41e-06	175	89	6	b8995e7ada85ba959f06264a0295b61e390c4e6c
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-stromal_related-T_reticular\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SPARC SFRP1 AGT C1R C7 SPATA1	1.41e-06	175	89	6	7ae76bd3b4f610b2f98716a4456437cd3696b686
ToppCell	5'-GW_trimst-2-LymphNode-Mesenchymal-fibroblastic-Stromal_3_(C7+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LIFR VLDLR SPARC SFRP1 C1R C7	1.89e-06	184	89	6	4d4d8f3f44c67d74c57e7af7b7c158f0157b2f49
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SPARC MRGPRF KIAA1755 ANTXR1 C1R C7	2.35e-06	191	89	6	0fae1c2ef9f83ac7721d0a9d69455bf97eed9257
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts-Alveolar_fibroblasts_L.2.1.4.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SPARC MRGPRF HHIPL2 SLC38A5 C1R C7	2.49e-06	193	89	6	5bee7abc550ddaa28cbb3b9ecaf6b924ab175de0
ToppCell	facs-GAT-Fat-3m-Mesenchymal-mesenchymal_progenitor\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VLDLR SPARC SFRP1 LAMB2 ANTXR1 C7	2.64e-06	195	89	6	69a29d03e664b72f32d41876510c62345c3aed31
ToppCell	ASK428-Mesenchymal\|ASK428 / Donor, Lineage and Cell class of Lung cells from Dropseq	SPARC ASPA SLC38A5 ANTXR1 C1R C7	2.64e-06	195	89	6	2b156163975d9a3d3fda1402acd9831d0fdc9e25
ToppCell	facs-GAT-Fat-3m-Mesenchymal\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VLDLR SPARC SFRP1 LAMB2 ANTXR1 C7	2.64e-06	195	89	6	1cffae2b08dbfa1c633ce24023e89b66d28b5431
ToppCell	ASK428-Mesenchymal-Fibroblast\|ASK428 / Donor, Lineage and Cell class of Lung cells from Dropseq	SPARC ASPA SLC38A5 ANTXR1 C1R C7	2.64e-06	195	89	6	c269c0d894a0f55da6495b59d4b9abb9f68df684
ToppCell	facs-GAT-Fat-3m-Mesenchymal-mesenchymal_stem_cell_of_adipose\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VLDLR SPARC SFRP1 LAMB2 ANTXR1 C7	2.64e-06	195	89	6	9cef6f18664518060af7c192310dddce6d70345a
ToppCell	metastatic_Lymph_Node-Fibroblasts\|metastatic_Lymph_Node / Location, Cell class and cell subclass	SPARC MRGPRF KIAA1755 ANTXR1 C1R C7	2.72e-06	196	89	6	275e153347caf94edc0c50021bbab49c8696fecb
ToppCell	tumor_Lung-Fibroblasts-COL14A1+_matrix_FBs\|tumor_Lung / Location, Cell class and cell subclass	SPARC SFRP1 MRGPRF ANTXR1 C1R C7	2.89e-06	198	89	6	74f2c7ef702b25a5b99e56121229e678ed992524
ToppCell	proximal-mesenchymal-Alveolar_Fibroblast\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	SPARC MRGPRF ASPA SLC38A5 C1R C7	2.97e-06	199	89	6	7f4840ae6a888380feca722543e5e52783f3e35d
ToppCell	stromal_cell\|World / Lineage and Cell class	LIFR SFRP1 MRGPRF ANTXR1 C1R C7	2.97e-06	199	89	6	507a82d0529b5b1fa5aebcfe43db53f0b6e3f8f0
ToppCell	stromal_cell-stromal_cell\|World / Lineage and Cell class	LIFR SFRP1 MRGPRF ANTXR1 C1R C7	2.97e-06	199	89	6	74262363a34da3a1eb55ab375fd61ddd7bb39b23
ToppCell	proximal-3-mesenchymal-Alveolar_Fibroblast\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	SPARC MRGPRF ASPA SLC38A5 C1R C7	2.97e-06	199	89	6	301d02bbb37e6f1d24b6e865bc3fe3e91260eb30
ToppCell	356C-Fibroblasts-Fibroblast-F\|356C / Donor, Lineage, Cell class and subclass (all cells)	SPARC SFRP1 MRGPRF ANTXR1 C1R C7	2.97e-06	199	89	6	59fe5f3c6338e019a149ab135acf9cc5657298bf
ToppCell	proximal-mesenchymal-Alveolar_Fibroblast-3\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	SPARC MRGPRF ASPA SLC38A5 C1R C7	2.97e-06	199	89	6	9a16e519fb0651a7c4d8e05b931df4fb3b0eb3d1
ToppCell	ILEUM-inflamed-(8)_Fibroblasts\|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	SPARC SFRP1 ASPA ANTXR1 C1R C7	2.97e-06	199	89	6	3a3e2bb21cd0293622b1a975263e918d9ba24265
ToppCell	356C-Fibroblasts-Fibroblast-F-\|356C / Donor, Lineage, Cell class and subclass (all cells)	SPARC SFRP1 MRGPRF ANTXR1 C1R C7	2.97e-06	199	89	6	136f24597ddca5cf2175120975c94782a3232ec6
ToppCell	Biopsy_Other_PF-Mesenchymal-Myofibroblasts\|Biopsy_Other_PF / Sample group, Lineage and Cell type	SPARC MRGPRF SLC38A5 ANTXR1 C1R C7	3.06e-06	200	89	6	e504570fd7eec1524c401b1cfa9d10822d80d994
ToppCell	Lung_Parenchyma-Severe-Mesenchymal-Mesenchymal-Fibroblasts-2,_SCARA5-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SPARC SFRP1 AGT KIAA1755 C1R C7	3.06e-06	200	89	6	0b2614b8513693dd508c9003699049efd9abac52
ToppCell	distal-3-mesenchymal-Pericyte\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	SPARC AFAP1L2 MRGPRF KCP C1R LRRC4B	3.06e-06	200	89	6	911db29f254bb697610e720ba78816e2c7f57933
ToppCell	normal_Lung-Fibroblasts\|normal_Lung / Location, Cell class and cell subclass	SPARC SFRP1 MRGPRF ANTXR1 C1R C7	3.06e-06	200	89	6	803cf7f1382d07220249029cd220233232027689
ToppCell	wk_20-22-Mesenchymal-Fibroblast-intermediate_fibro\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	LIFR SPARC SFRP1 ASPA C1R C7	3.06e-06	200	89	6	d769723f8fcb37d9b86589e0c41c1d7f16393cfe
ToppCell	Lung_Parenchyma-Severe-Mesenchymal-Mesenchymal-Fibroblasts-2,_SCARA5\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	SPARC SFRP1 AGT KIAA1755 C1R C7	3.06e-06	200	89	6	8d2ceb2080c67b20f452eeca605aa27a58033c04
ToppCell	Biopsy_IPF-Mesenchymal-Fibroblasts\|Biopsy_IPF / Sample group, Lineage and Cell type	SPARC SFRP1 MRGPRF KIAA1755 C1R C7	3.06e-06	200	89	6	d8637f1e62d3fb9476dc51e1b1dc2f4b14b5fcd8
ToppCell	(5)_Fibroblast-E\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	SPARC SFRP1 AGT KIAA1755 C1R C7	3.06e-06	200	89	6	75e5ecb05e965e24d569aa2ef5cdf740b1528c06
ToppCell	wk_15-18-Mesenchymal-Fibroblast-intermediate_fibro\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	LIFR SPARC SFRP1 ASPA C1R C7	3.06e-06	200	89	6	6461d25fd8fb52921b188f083fbe808535d3130b
ToppCell	normal_Lung-Fibroblasts-COL14A1+_matrix_FBs\|normal_Lung / Location, Cell class and cell subclass	SPARC SFRP1 MRGPRF ANTXR1 C1R C7	3.06e-06	200	89	6	ee3d06865a6300e1279edf6664320b71647f5efb
ToppCell	Parenchyma_COVID-19-Stromal-TX-Fibroblasts-2,_SCARA5\|Parenchyma_COVID-19 / Sample group, Lineage and Cell type	SPARC SFRP1 AGT KIAA1755 C1R C7	3.06e-06	200	89	6	c338a08c1605527ab9aaf62ea151a19e8469dc6d
ToppCell	distal-3-mesenchymal-Alveolar_Fibroblast\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	SPARC MRGPRF ASPA SLC38A5 C1R C7	3.06e-06	200	89	6	20112be28f80baffad92641c9cfd7c3718967dbb
ToppCell	356C-Fibroblasts-Fibroblast-C_(Myofibroblast)\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	RALGAPA1 LIFR E2F7 RWDD3 KCNRG	9.79e-06	142	89	5	7b6678a73d04feac12bbc909f2df478215511de0
ToppCell	356C-Fibroblasts-Fibroblast-C_(Myofibroblast)-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	RALGAPA1 LIFR E2F7 RWDD3 KCNRG	9.79e-06	142	89	5	347f5832a86f4e41752e36e3e737df7ca6f79e90
ToppCell	356C-Myeloid-Macrophage-FABP4+_Macrophage_3\|356C / Donor, Lineage, Cell class and subclass (all cells)	IQCH MRGPRF TMPRSS11E KIAA1755 C7	1.50e-05	155	89	5	e1a20e88b9c0eaf7ca7004acc0eda096d1588563
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell_cycling-Cycling_Connecting_Tubule_Cell_S-high\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	RAD54B E2F7 LAMA3 NDUFAF6 HELLS	2.14e-05	167	89	5	108ae6221c6edc63c0ec42c42471b3a15a594043
ToppCell	PND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_prolif\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	VLDLR SFRP1 SLC38A5 ACOT6 HELLS	2.33e-05	170	89	5	e20568c8f3f17d94de78229617eb2f7e4c5af2bc
ToppCell	PND07-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RAD54B TOPBP1 E2F7 F2 HELLS	2.61e-05	174	89	5	66555c610251ea04f968c258e312d720c18e7cde
ToppCell	PND14-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1/AT2\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	VLDLR XPO5 DOCK7 LAMA3 VEGFA	2.68e-05	175	89	5	96219e58dcb327fd27190be78193e7a0d611e62b
ToppCell	PND14-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1/AT2-AT1/AT2_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	VLDLR XPO5 DOCK7 LAMA3 VEGFA	2.68e-05	175	89	5	cb974fbebe8cb58c7d3f7defabb4e056f2fee5fa
ToppCell	(0)_Normal/No_Treatment-(3)_LEPR+_perivascular_cells\|World / Stress and Cell class	LIFR SPARC SFRP1 ANTXR1 VEGFA	2.75e-05	176	89	5	ce2c32b5ce0da848eb4da35ce4d215cdf74d9113
ToppCell	343B-Fibroblasts-Fibroblast-A_(Fibroblast_progenitors)-\|343B / Donor, Lineage, Cell class and subclass (all cells)	SPARC SFRP1 ASPA C1R C7	2.75e-05	176	89	5	2e94bbe17c0bb65dc58b4ebc0cb829258bd7373b
ToppCell	356C-Fibroblasts-Fibroblast-A_(Fibroblast_progenitors)\|356C / Donor, Lineage, Cell class and subclass (all cells)	SPARC SFRP1 ANTXR1 C1R C7	2.75e-05	176	89	5	135d51d28a7ad2a67d5a6c49eb6e661f4beb66f5
ToppCell	356C-Fibroblasts-Fibroblast-A_(Fibroblast_progenitors)-\|356C / Donor, Lineage, Cell class and subclass (all cells)	SPARC SFRP1 ANTXR1 C1R C7	2.75e-05	176	89	5	2287bd8382f41e36ebb0875a0133bada1ec81fa7
ToppCell	343B-Fibroblasts-Fibroblast-A_(Fibroblast_progenitors)\|343B / Donor, Lineage, Cell class and subclass (all cells)	SPARC SFRP1 ASPA C1R C7	2.75e-05	176	89	5	f33ab41d121b59d871ad7d48ca021524a027d2ef
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	RAD54B E2F7 LAMA3 NDUFAF6 HELLS	2.99e-05	179	89	5	88d44b04eb5c079531db663ed98ddb20b60feb9a
ToppCell	3'-Distal_airway-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SPARC SFRP1 MRGPRF C1R C7	3.32e-05	183	89	5	2beb5414958d38a5341870d55229f3b1707e76bf
ToppCell	droplet-Limb_Muscle-nan-3m-Macroglial-Schwann_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SFRP1 AFAP1L2 ASPA LRRC4B ACOT1	3.32e-05	183	89	5	2cf36ad89584eb9f8b04de52a1b511b7f3527884
ToppCell	droplet-Limb_Muscle-nan-3m-Macroglial\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SFRP1 AFAP1L2 ASPA LRRC4B ACOT1	3.32e-05	183	89	5	98fee6838acfaee5e2e449ba088764ec06b8bc57
ToppCell	droplet-Lung-18m-Hematologic-lymphocytic-Proliferating_T_cell-proliferating_T\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RAD54B E2F7 KIAA1755 UBASH3A HELLS	3.40e-05	184	89	5	1edefa2a049d7e22d0bdb1ea3d7ef1c8d6ae0fe3
ToppCell	droplet-Lung-18m-Hematologic-lymphocytic-Proliferating_T_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RAD54B E2F7 KIAA1755 UBASH3A HELLS	3.40e-05	184	89	5	8578c50eaa8ce1cefc0228185c66c8e25f4bfc32
ToppCell	Adult-Mesenchymal-matrix_fibroblast_2_cell-D231\|Adult / Lineage, Cell type, age group and donor	SFRP1 KIAA1755 ANTXR1 C1R C7	3.49e-05	185	89	5	fb6bd7e849ecf4ed9cd9c4e2a946a2d12d62f804
ToppCell	Adult-Mesenchymal-pericyte_cell\|Adult / Lineage, Cell type, age group and donor	SPARC AFAP1L2 STARD9 KCP LRRC4B	3.68e-05	187	89	5	62759efb660179402fb574ce5701c89a2e17bcfe
ToppCell	TCGA-Breast-Primary_Tumor-Breast_Carcinoma-Infiltrating_Lobular_Carcinoma-6\|TCGA-Breast / Sample_Type by Project: Shred V9	TGFB1 SHROOM1 MRGPRF LRRC4B C7	3.77e-05	188	89	5	c90669b51e1902fe7726555290c91c92a911df83
ToppCell	droplet-Heart-HEART-1m-Neuronal-cardiac_neuron\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SFRP1 AFAP1L2 ASPA LRRC4B ACOT6	3.77e-05	188	89	5	921a2c9212a0f2a00fd72c594d80924f27e8b9b7
ToppCell	10x5'v1-week_14-16-Mesenchymal_fibro-stroma\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	SPARC MRGPRF ANTXR1 C1R FRMPD3	3.87e-05	189	89	5	eccf3d49354a67c94f1ed7c15a98a48a5e8e2ed0
ToppCell	10x5'v1-week_14-16-Mesenchymal_fibro\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	SPARC MRGPRF ANTXR1 C1R FRMPD3	3.87e-05	189	89	5	40764f461b8aa1d3a2c5a30590b7fb9307d47d09
ToppCell	facs-SCAT-Fat-24m-Mesenchymal-mesenchymal_progenitor\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPARC SFRP1 AGT LAMB2 C7	3.97e-05	190	89	5	dc7e92f1b18d0f5efec11d09d56ba954d4f8b3bd
ToppCell	facs-SCAT-Fat-24m-Mesenchymal-mesenchymal_stem_cell_of_adipose\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPARC SFRP1 AGT LAMB2 C7	3.97e-05	190	89	5	0bb06df3d5a50416854370f234718c6cec3d773b
ToppCell	PND01-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_mature\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SPARC SFRP1 MRGPRF KIAA1755 ANTXR1	3.97e-05	190	89	5	947807863a9b247c301c6cf63d6fd5a2c8018e66
ToppCell	facs-SCAT-Fat-24m-Mesenchymal\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPARC SFRP1 AGT LAMB2 C7	3.97e-05	190	89	5	008290bb5c79446681dd6bf354336c57ad0d6f13
ToppCell	PCW_13-14\|World / Celltypes from embryonic and fetal-stage human lung	LIFR ASPA AFDN C7 KDM5D	3.97e-05	190	89	5	62a3ec1ae0829602b0569cc051210551644f1d46
ToppCell	10x5'v1-week_14-16-Mesenchymal_fibro-stroma-arteriolar_fibroblast\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	SPARC MRGPRF ANTXR1 C1R FRMPD3	4.07e-05	191	89	5	5271198116343c07202649889057e5774d7fdde3
ToppCell	PND01-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SPARC SFRP1 MRGPRF KIAA1755 ANTXR1	4.07e-05	191	89	5	db4943dd19207663fb9e27f8940fa4b06a933625
ToppCell	metastatic_Lymph_Node-Fibroblasts-Myofibroblasts\|metastatic_Lymph_Node / Location, Cell class and cell subclass	SPARC MRGPRF KIAA1755 ANTXR1 C1R	4.07e-05	191	89	5	aa43b472bc8362f79ae63f09f1ca764718bbf22c
ToppCell	facs-GAT\|facs / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VLDLR SFRP1 AGT ASPA SLC38A5	4.07e-05	191	89	5	1f5d1e8c313a8dc83c06d2ee45f369b0ec507fbf
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_2_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	VLDLR SPARC KIAA1755 C1R C7	4.17e-05	192	89	5	e0f4e4470a71bfa81d9dcd8594e5f82aafc24f81
ToppCell	Mesenchymal-matrix_fibroblast_2_cell\|World / Lineage, Cell type, age group and donor	SPARC KIAA1755 ANTXR1 C1R C7	4.17e-05	192	89	5	a769158c49d2b208c4224d85e7ae68c85cc372ed
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Degenerative_Fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SPARC KIAA1755 ANTXR1 C1R C7	4.27e-05	193	89	5	dc8e62df6121ee99b156aca6b1b3ae555739b6f2
ToppCell	21-Trachea-Epithelial-Epithelial\|Trachea / Age, Tissue, Lineage and Cell class	SPARC KIAA1755 C1R LRRC4B C7	4.27e-05	193	89	5	9a8bb44a37f3202e3123a6680bd5545dc91a6d40
ToppCell	10x5'v1-week_12-13-Mesenchymal_fibro-stroma-arteriolar_fibroblast\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	MRGPRF KIAA1755 ANTXR1 C1R LRRC4B	4.27e-05	193	89	5	3d85c28f6ebdcb15e875ad01d52d6c138fbf8525
ToppCell	10x3'2.3-week_14-16-Mesenchymal_fibro-stroma-arteriolar_fibroblast\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	SFRP1 MRGPRF ANTXR1 C1R LRRC4B	4.27e-05	193	89	5	09de51f8ac509e03d480ed3dc9dfe7e7defc59cb
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_2_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SPARC KIAA1755 ANTXR1 C1R C7	4.27e-05	193	89	5	9ab47b360bee1d4f1092c2269e58acebe9584021
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_119\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SPARC KIAA1755 ANTXR1 C1R C7	4.27e-05	193	89	5	e2ee077fd381bd906e6b4329f22e7d106e422a7f
ToppCell	3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SPARC SFRP1 ASPA KIAA1755 C1R	4.38e-05	194	89	5	35b30bc954750e939f81a9a7498b8bc2ce69a299
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_adventitial_fibro_(9)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	LIFR SPARC SFRP1 ASPA C7	4.38e-05	194	89	5	99577a5a631e607b5abe7a1b0d8d6a5eabe50196
ToppCell	facs-Trachea-24m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l1\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SPARC SFRP1 LAMB2 ANTXR1 C7	4.38e-05	194	89	5	889c6e231bdd5b59902c7d2afdc077360b1d3256
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_adventitial_fibro_(9)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	LIFR SPARC SFRP1 ASPA C7	4.49e-05	195	89	5	70387a62f121f8c374dba1aca9ab65cfed6a0b10
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_2_cell-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	SPARC SFRP1 MRGPRF C1R C7	4.60e-05	196	89	5	525d6c8a277364e624e7cc586275f8a891436b57
ToppCell	356C-Fibroblasts-Fibroblast-K_(Pericytes)\|356C / Donor, Lineage, Cell class and subclass (all cells)	SPARC MRGPRF AGT ANTXR1 C1R	4.60e-05	196	89	5	a5cc4f76e1a3825aaccba9a686d7da6f7e4300ff
ToppCell	3'-Broncho-tracheal-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell-Pericytes\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SPARC AFAP1L2 STARD9 MRGPRF LRRC4B	4.60e-05	196	89	5	9d18381d7aaa063094a5df769a04c73350471525
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_1_(CCL11+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NBPF3 LIFR SPARC ANTXR1 C1R	4.60e-05	196	89	5	2ab9735aa7a7e95dcf6b0bdf0427f7b57f6349ee
ToppCell	356C-Fibroblasts-Fibroblast-K_(Pericytes)-\|356C / Donor, Lineage, Cell class and subclass (all cells)	SPARC MRGPRF AGT ANTXR1 C1R	4.60e-05	196	89	5	476812fc1422aca8010d771eff11fa6081f15a2d
ToppCell	3'-Broncho-tracheal-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell-Pericytes-Pericytes_L.2.3.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SPARC AFAP1L2 STARD9 MRGPRF LRRC4B	4.60e-05	196	89	5	a52cb512c6173be92aa9c4d96e2abbc32f45478d
ToppCell	3'-Broncho-tracheal-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SPARC AFAP1L2 STARD9 MRGPRF LRRC4B	4.60e-05	196	89	5	afddacc0fb8b9c73dad5333137deb471a6ebdc06
ToppCell	MatrixFB\|World / shred on cell class and cell subclass (v4)	VLDLR SPARC AGT SLC38A5 ANTXR1	4.71e-05	197	89	5	e325de44e32021a36fffb7b7e88167b46bb051c7
ToppCell	(5)_Fibroblasts-(5)_Fibroblast-E\|(5)_Fibroblasts / Lung cell shreds - cell class (v4) and cell subclass (v4)	SFRP1 AGT LAMB2 C1R C7	4.71e-05	197	89	5	9b1c1d72c5a8c90d71ae31e4c198d2276872eaa0
ToppCell	PND01-Mesenchymal\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	VLDLR SPARC SFRP1 AGT SLC38A5	4.71e-05	197	89	5	292b8cc3dafddf5d323fe4e3d3ea5ac61e6ce027
ToppCell	5'-GW_trimst-2-LargeIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NBPF3 KIAA1755 ANTXR1 C1R VEGFA	4.71e-05	197	89	5	236a40eb6c08e1d179cf0fb5450b032975c5f6b6
ToppCell	5'-GW_trimst-2-LymphNode-Mesenchymal\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LIFR SPARC LAMA3 C1R C7	4.71e-05	197	89	5	5fbbc570a4e77c703f569a4f85ce2d8af67d6297
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SPARC KIAA1755 ANTXR1 C1R C7	4.71e-05	197	89	5	4cf4e9553397cd8dee883dbec24f41bec41aff99
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	VLDLR SPARC SFRP1 C1R C7	4.71e-05	197	89	5	6b6440f1baad5680cf9e13ca3ab72a2c65523d59
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW09-Neuronal-GABAergic_neurons\|GW09 / Sample Type, Dataset, Time_group, and Cell type.	LIFR TM2D2 MAP3K9 KCP C7	4.71e-05	197	89	5	21f3ef7c3c10b4e3adde431097dfdcd513c74a95
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts-Alveolar_fibroblasts_L.2.1.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SPARC ASPA SLC38A5 C1R C7	4.71e-05	197	89	5	13896ec65ccda0b928c91d41112dc01b480036b7
ToppCell	5'-GW_trimst-2-SmallIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SPARC KIAA1755 ANTXR1 C1R VEGFA	4.83e-05	198	89	5	09be07ebfc3e49c3858e9b74605b69cf4fc28b56
ToppCell	(7)_Epithelial_cells-(7)_Epithelial-E_(AT2)\|(7)_Epithelial_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)	TGFB1 SPARC C7 KDM5D VEGFA	4.83e-05	198	89	5	498f11441c0a0982738537bcfcfc2877866b7400
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Subpleural_fibroblasts-Subpleural_fibroblasts_L.2.1.5.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SPARC MRGPRF KIAA1755 C1R C7	4.83e-05	198	89	5	c66097ae9ba0b50561083c423565665958ef0bb8
ToppCell	Fibroblasts-HLA-DRA_high_Fibroblasts\|World / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	LIFR SPARC KIAA1755 ANTXR1 C1R	4.83e-05	198	89	5	e8c0fbf306fae13e97caa294d7c99a564bd97130
ToppCell	3'-GW_trimst-2-LargeIntestine-Mesenchymal-fibroblastic\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LIFR SPARC SFRP1 C1R C7	4.83e-05	198	89	5	d9ffc6589ed510ffa60c591f2a0fe123210f1455
Computational	Genes upregulated in subsets of cells of a given type within various tumors	SPARC SFRP1 ANTXR1 C1R	8.81e-05	50	51	4	GAVISH_3CA_MALIGNANT_METAPROGRAM_15_EMT_4
Drug	benzylamide	TGFB1 SPARC F2 VEGFA	3.12e-06	27	86	4	CID000010391
Disease	syndromic X-linked intellectual disability Claes-Jensen type (implicated_via_orthology)	KDM5A KDM5C KDM5D	1.02e-07	4	88	3	DOID:0060809 (implicated_via_orthology)
Disease	Liver Cirrhosis	TGFB1 SPARC ARRB1 AGT F2 VEGFA	6.71e-07	103	88	6	C0023890
Disease	Fibrosis, Liver	TGFB1 SPARC ARRB1 AGT F2 VEGFA	7.52e-07	105	88	6	C0239946
Disease	Degenerative Intervertebral Discs	TGFB1 SPARC	8.79e-06	2	88	2	C2717759
Disease	syndromic intellectual disability (implicated_via_orthology)	KDM5A KDM5C KDM5D	1.40e-05	16	88	3	DOID:0050888 (implicated_via_orthology)
Disease	chronic obstructive pulmonary disease (implicated_via_orthology)	TGFB1 MUC5AC	2.63e-05	3	88	2	DOID:3083 (implicated_via_orthology)
Disease	Intervertebral Disc Degeneration	TGFB1 SPARC	2.63e-05	3	88	2	C0158266
Disease	Hypothyroidism	KDM5C TSHB	5.26e-05	4	88	2	C0020676
Disease	diabetic angiopathy (biomarker_via_orthology)	SPARC VEGFA	5.26e-05	4	88	2	DOID:11713 (biomarker_via_orthology)
Disease	bullous pemphigoid (is_marker_for)	F2 VEGFA	5.26e-05	4	88	2	DOID:8506 (is_marker_for)
Disease	pre-eclampsia (is_implicated_in)	AGT F2 VEGFA	5.62e-05	25	88	3	DOID:10591 (is_implicated_in)
Disease	intellectual disability (implicated_via_orthology)	KDM5A KDM5C UBR4 KDM5D	7.64e-05	75	88	4	DOID:1059 (implicated_via_orthology)
Disease	lung small cell carcinoma (is_implicated_in)	PBRM1 XPO5 LAMA3	7.96e-05	28	88	3	DOID:5409 (is_implicated_in)
Disease	limb ischemia (implicated_via_orthology)	GRK2 VEGFA	8.74e-05	5	88	2	DOID:0050852 (implicated_via_orthology)
Disease	Crohn's disease (is_marker_for)	PBRM1 F2 VEGFA	8.85e-05	29	88	3	DOID:8778 (is_marker_for)
Disease	Bipolar Disorder	TGFB1 SFRP1 PBRM1 STARD9 AGT TSHB TPH1 VEGFA	9.13e-05	477	88	8	C0005586
Disease	proteinuria (implicated_via_orthology)	TGFB1 LAMB2 VEGFA	9.82e-05	30	88	3	DOID:576 (implicated_via_orthology)
Disease	liver cirrhosis (is_marker_for)	TGFB1 GRK2 F2 VEGFA	1.08e-04	82	88	4	DOID:5082 (is_marker_for)
Disease	colorectal cancer (is_marker_for)	TGFB1 PBRM1 KDM5C ANTXR1 VEGFA	1.10e-04	157	88	5	DOID:9256 (is_marker_for)
Disease	Paratuberculosis	C1R F2	1.31e-04	6	88	2	C0030524
Disease	Liver Failure	F2 VEGFA	1.31e-04	6	88	2	C0085605
Disease	atherosclerosis (implicated_via_orthology)	AGT F2	1.83e-04	7	88	2	DOID:1936 (implicated_via_orthology)
Disease	nephrosis (implicated_via_orthology)	LAMB2 F2	1.83e-04	7	88	2	DOID:2527 (implicated_via_orthology)
Disease	cerebrospinal fluid biomarker measurement	AGT KIAA1755 C1R C7	1.99e-04	96	88	4	EFO_0006794
Disease	chronic obstructive pulmonary disease (is_marker_for)	TGFB1 F2 MUC5AC VEGFA	2.07e-04	97	88	4	DOID:3083 (is_marker_for)
Disease	breast cancer (is_marker_for)	TGFB1 KDM5A KDM5C AGT ANTXR1	2.36e-04	185	88	5	DOID:1612 (is_marker_for)
Disease	Nodular glomerulosclerosis	TGFB1 AGT VEGFA	2.52e-04	41	88	3	C0017667
Disease	Proteinuria	TGFB1 AGT VEGFA	2.90e-04	43	88	3	C0033687
Disease	alcohol use disorder (implicated_via_orthology)	PBRM1 KDM5A PIK3CD KDM5C KDM5D	3.01e-04	195	88	5	DOID:1574 (implicated_via_orthology)
Disease	Diabetic Nephropathy	TGFB1 AGT VEGFA	3.11e-04	44	88	3	C0011881
Disease	vascular endothelial growth factor A, isoform 121 measurement	VLDLR VEGFA	3.12e-04	9	88	2	EFO_0020847
Disease	Endomyocardial Fibrosis	TGFB1 AGT	3.12e-04	9	88	2	C0553980
Disease	X-17653 measurement	ACOT6 HELLS	3.12e-04	9	88	2	EFO_0800783
Disease	Streptozotocin Diabetes	TGFB1 AGT ACOT1 VEGFA	3.12e-04	108	88	4	C0038433
Disease	Diabetes Mellitus, Experimental	TGFB1 AGT ACOT1 VEGFA	3.12e-04	108	88	4	C0011853
Disease	Alloxan Diabetes	TGFB1 AGT ACOT1 VEGFA	3.12e-04	108	88	4	C0002152
Disease	Heart Diseases	SFRP1 AGT VEGFA	3.55e-04	46	88	3	C0018799
Disease	rhinitis (is_marker_for)	TGFB1 MUC5AC VEGFA	3.55e-04	46	88	3	DOID:4483 (is_marker_for)
Disease	allergic rhinitis (biomarker_via_orthology)	TGFB1 MUC5AC	3.90e-04	10	88	2	DOID:4481 (biomarker_via_orthology)
Disease	corneal resistance factor	EXOSC10 SFRP1 IQCH ANTXR1 NDUFAF6 BRAT1 SHLD3	4.07e-04	451	88	7	EFO_0010067
Disease	Fibrosis	TGFB1 SFRP1 AGT	4.54e-04	50	88	3	C0016059
Disease	Cirrhosis	TGFB1 SFRP1 AGT	4.54e-04	50	88	3	C1623038
Disease	Diabetic Retinopathy	AGT VEGFA	4.75e-04	11	88	2	C0011884
Disease	autoimmune hepatitis (is_marker_for)	F2 VEGFA	4.75e-04	11	88	2	DOID:2048 (is_marker_for)
Disease	glomerulonephritis (is_implicated_in)	F2 VEGFA	4.75e-04	11	88	2	DOID:2921 (is_implicated_in)
Disease	factor VIII deficiency (is_implicated_in)	TGFB1 F2	4.75e-04	11	88	2	DOID:12134 (is_implicated_in)
Disease	Ashkenazi Jewish disorders	TGFB1 ASPA	4.75e-04	11	88	2	cv:CN118946
Disease	systemic scleroderma (is_marker_for)	AGT F2 VEGFA	5.39e-04	53	88	3	DOID:418 (is_marker_for)
Disease	asthma (is_marker_for)	TGFB1 F2 MUC5AC VEGFA	5.60e-04	126	88	4	DOID:2841 (is_marker_for)
Disease	pulmonary fibrosis (implicated_via_orthology)	TGFB1 AGT	5.69e-04	12	88	2	DOID:3770 (implicated_via_orthology)
Disease	Leigh disease (implicated_via_orthology)	NDUFAF6 NDUFA10	5.69e-04	12	88	2	DOID:3652 (implicated_via_orthology)
Disease	vascular endothelial growth factor A measurement	VLDLR VEGFA	5.69e-04	12	88	2	EFO_0010804
Disease	focal segmental glomerulosclerosis (biomarker_via_orthology)	VLDLR AGT	5.69e-04	12	88	2	DOID:1312 (biomarker_via_orthology)
Disease	renal cell carcinoma (is_marker_for)	TGFB1 SPARC SFRP1 VEGFA	5.94e-04	128	88	4	DOID:4450 (is_marker_for)
Disease	triglycerides to total lipids in medium HDL percentage	DOCK7 NLRC5 VEGFA	6.34e-04	56	88	3	EFO_0022333
Disease	cholesteryl esters to total lipids in medium HDL percentage	DOCK7 NLRC5 VEGFA	6.34e-04	56	88	3	EFO_0022251
Disease	hyperglycemia (is_marker_for)	TSHB F2	6.71e-04	13	88	2	DOID:4195 (is_marker_for)
Disease	multiple myeloma (is_implicated_in)	TGFB1 XPO5 VEGFA	7.38e-04	59	88	3	DOID:9538 (is_implicated_in)
Disease	type 2 diabetes mellitus (is_marker_for)	TGFB1 AGT F2 VEGFA	7.46e-04	136	88	4	DOID:9352 (is_marker_for)
Disease	triglycerides to total lipids in large HDL percentage	DOCK7 NLRC5 VEGFA	7.76e-04	60	88	3	EFO_0022330
Disease	cholesterol to total lipids in medium HDL percentage	DOCK7 NLRC5 VEGFA	7.76e-04	60	88	3	EFO_0022237
Disease	gastric ulcer (implicated_via_orthology)	AGT MUC5AC	7.82e-04	14	88	2	DOID:10808 (implicated_via_orthology)
Disease	membranous glomerulonephritis (biomarker_via_orthology)	SPARC C7	7.82e-04	14	88	2	DOID:10976 (biomarker_via_orthology)
Disease	sickle cell anemia (is_marker_for)	TGFB1 F2	7.82e-04	14	88	2	DOID:10923 (is_marker_for)
Disease	Nephrosis	AGT F2	9.00e-04	15	88	2	C0027720
Disease	brain edema (biomarker_via_orthology)	F2 VEGFA	9.00e-04	15	88	2	DOID:4724 (biomarker_via_orthology)
Disease	impotence (implicated_via_orthology)	GRK2 AGT	9.00e-04	15	88	2	DOID:1875 (implicated_via_orthology)
Disease	level of Phosphatidylcholine (18:0_18:2) in blood serum	DOCK7 RWDD3	1.03e-03	16	88	2	OBA_2045090
Disease	autism spectrum disorder (implicated_via_orthology)	KDM5A KDM5C KDM5D TPH1	1.13e-03	152	88	4	DOID:0060041 (implicated_via_orthology)
Disease	Uremia	TGFB1 SPARC	1.16e-03	17	88	2	C0041948
Disease	Non-alcoholic Fatty Liver Disease	TGFB1 VLDLR F2	1.21e-03	70	88	3	C0400966
Disease	Nonalcoholic Steatohepatitis	TGFB1 VLDLR F2	1.21e-03	70	88	3	C3241937
Disease	Hypertrophy	AGT F2	1.30e-03	18	88	2	C0020564
Disease	triglycerides to total lipids in small HDL percentage	DOCK7 NLRC5 VEGFA	1.32e-03	72	88	3	EFO_0022336
Disease	osteochondrodysplasia (is_implicated_in)	TGFB1 LIFR	1.45e-03	19	88	2	DOID:2256 (is_implicated_in)
Disease	inflammatory bowel disease (is_implicated_in)	TGFB1 AGT	1.45e-03	19	88	2	DOID:0050589 (is_implicated_in)
Disease	toxic shock syndrome (is_marker_for)	GRK2 F2	1.45e-03	19	88	2	DOID:14115 (is_marker_for)
Disease	interleukin 10 measurement	VLDLR MRPL37 VEGFA	1.66e-03	78	88	3	EFO_0004750
Disease	Depressive disorder	TGFB1 SFRP1 AGT TPH1 VEGFA	1.76e-03	289	88	5	C0011581
Disease	Left Ventricle Remodeling	TGFB1 AGT	1.78e-03	21	88	2	C0600520
Disease	Ventricular Remodeling	TGFB1 AGT	1.78e-03	21	88	2	C0600519
Disease	platelet component distribution width	AFAP1L2 BRF1 DOCK7 ANTXR1 NDUFAF6 RWDD3 BRAT1 VEGFA	1.88e-03	755	88	8	EFO_0007984
Disease	portal hypertension (biomarker_via_orthology)	GRK2 VEGFA	1.95e-03	22	88	2	DOID:10762 (biomarker_via_orthology)
Disease	Liver Cirrhosis, Experimental	TGFB1 SPARC AGT DOCK7 NLRC5 C7 VEGFA HELLS	2.20e-03	774	88	8	C0023893
Disease	Ureteral obstruction	TGFB1 AGT	2.33e-03	24	88	2	C0041956
Disease	Kidney Diseases	TGFB1 SPARC AGT	2.34e-03	88	88	3	C0022658
Disease	paracentral lobule volume measurement	STXBP5L C7	2.52e-03	25	88	2	EFO_0010317
Disease	middle cerebral artery infarction (biomarker_via_orthology)	TGFB1 AGT VEGFA	2.74e-03	93	88	3	DOID:3525 (biomarker_via_orthology)
Disease	Myocardial Infarction	TGFB1 AGT F2	2.91e-03	95	88	3	C0027051
Disease	Nephrotic Syndrome	TGFB1 XPO5	2.94e-03	27	88	2	C0027726
Disease	chronic myeloid leukemia (is_marker_for)	TGFB1 AGT	2.94e-03	27	88	2	DOID:8552 (is_marker_for)

Protein segments in the cluster

Peptide	Gene	Start	Entry
QIICYPETGHYIEPP	ACOT1	351	Q86TX2
LLQNYHCAPDEPFIP	AFDN	881	P55196
THCPYAVALPEVAPA	BRAT1	671	Q6PJG6
PFSVEDTYLLCPAPI	ANTXR1	271	Q9H6X2
CEVVPDPSPDHLYSF	AFAP1L2	401	Q8N4X5
QIICYPETGHCIDPP	ACOT6	351	Q3I5F7
LHLVHQAPCNVPPYL	TENT2	366	Q6PIY7
TVGEICLPYPIEHPY	C7orf31	136	Q8N865
PNLLPICLPDNDTFY	C1R	571	P00736
HAPECEPPFQELTIY	CDHR4	546	A6H8M9
HAYPFTFEIPPNLPC	ARRB1	111	P49407
PFTESACLLLIQPHY	AGT	326	P01019
VPPDLFQPYIEEICQ	GRK2	141	P25098
YCFEAPTLATLDPPH	RAD54B	86	Q9Y620
HCTDPYFTPIPVLQA	IQCH	151	Q86VS3
LLCHLFVPFTPPEPY	ITPRIP	206	Q8IWB1
LPTVDPIAVCHELYN	PBRM1	41	Q86U86
CNHPYLIEYPIDPVT	HELLS	571	Q9NRZ9
PPQENCLLYQHLPVT	LAMA3	886	Q16787
SQLPAVLEGPFPYCH	KIAA1755	701	Q5JYT7
INPPPYLTCESFPHA	HDHD2	236	Q9H0R4
LPTCEPTVPYHTILF	KATNIP	1541	O60303
HFQPPHPNCLYTVEL	CFAP65	716	Q6ZU64
DDNYHIFCLLPPLPE	KDM5D	336	Q9BY66
INCLEPHPYLPVLAC	DCAF8L2	516	P0C7V8
VEDIYCDNPPHQPVA	NDUFAF6	121	Q330K2
HARYLIFPNPVCLEP	LAMB2	671	P55268
PQPYDPRLHEVECSV	LRATD2	71	Q96KN1
LPPQRPSYHDLVFQC	KCNRG	166	Q8N5I3
EPCHTVIPPLLFYEG	MUC5AC	5156	P98088
SIYEPPPEEVTCSHQ	PLA2G2F	146	Q9BZM2
FYPISPIIDLHECNI	MRPL37	256	Q9BZE1
DSYHTFCLIPPLPDV	KDM5A	316	P29375
PYQLPFHNFPLTCTD	NLRC5	636	Q86WI3
CDYLPPHLVIYIDVP	NDUFA10	196	O95299
STPFEYLELPDLCQP	NBPF3	426	Q9H094
QPQLYRPIEETPCHF	EXOSC10	276	Q01780
PYIPPHAALCLEVTL	FKBP8	186	Q14318
LSVDPEYCVNPLAHP	E2F7	486	Q96AV8
IDISPAPENPHYCLT	DOCK7	511	Q96N67
APENPHYCLTPELLQ	DOCK7	516	Q96N67
PPPADSELVSFCYLH	FRMPD3	551	Q5JV73
LEPHCFPLSLVPTEF	C7	556	P10643
VYIPVLPPHLLDYCC	DENND1A	226	Q8TEH3
GDIVNCLEPHPYLPV	DCAF8L1	481	A6NGE4
VSVHCPVFDYVPPEL	EIF2B2	306	P49770
PFQPPLHLEFCSDYE	HHIPL2	51	Q6UWX4
EDPSCYPPIQLLEID	MAP3K9	126	P80192
VPCQDLTEPYIPHYT	FAM166A	76	Q6J272
PENHVVVSYCPPIIE	LIFR	941	P42702
QSHFTCYAPVIVEPP	LRRC4B	356	Q9NT99
LDFLSLIPVDPQYCP	PIAS2	551	O75928
QIPAPFPEYVTDLCI	MRGPRF	266	Q96AM1
CHPEVLPIYTELCRP	SLC38A5	271	Q8WUX1
PRFPDITEDCYLHPN	TAF1B	291	Q53T94
VVPPEPFFAACVYDL	KCP	1426	Q6ZWJ8
LPDPNVQKYIHPCEI	PRDM15	1046	P57071
ILHYRPCESDPTQLP	SHLD3	6	Q6ZNX1
PVCFDYVLPPILQCQ	SIAH2	81	O43255
GQVTVPTEYPLHECP	SHROOM1	431	Q2M3G4
IDAYFQPCQDPRLIP	CCT8L1P	396	A6NM43
YLDPQFQPHCELQPH	STARD9	1276	Q9P2P6
FYTKPPQCVDIPADL	SFRP1	51	Q8N474
PQAILCHPSLQPEEY	OS9	241	Q13438
EYITLPDHPSLPCQP	SPATA1	266	Q5VX52
PIVEFLTLCETPYPN	STXBP5L	356	Q9Y2K9
DVQQLACDPYLLPHI	TLK2	731	Q86UE8
SLAPLPCYVYLIEHP	ASPA	146	P45381
LPSFHPYQPLECIVE	ANKHD1	766	Q8IWZ3
PVPYTNAVHRVCLPD	TMPRSS11E	286	Q9UL52
IECTLELYPPQVNFP	UBA3	221	Q8TBC4
DPFYTPEPDTCHELL	TPH1	261	P17752
LELVFHLPVNYPSCL	RWDD3	51	Q9Y3V2
PHSPVILCSYLPDEF	TM2D2	66	Q9BX73
VFLVPADPHCRPTQY	USP4	491	Q13107
NLYCELPSLHPNIPD	RALGAPA1	1246	Q6GYQ0
YIPPCLDSELTEFPL	SPARC	151	P09486
CVPQALEPLPIVYYV	TGFB1	356	P01137
VKPLVLFCPPEHYEA	XPO5	896	Q9HAV4
LFCPPEHYEALVSPI	XPO5	901	Q9HAV4
LLICLPEVAPHPVYY	PIK3CD	471	O00329
EELSTLQAHYIPPVC	SLF1	431	Q9BQI6
INAPAIDPCLYIPRF	BRF1	176	Q92994
TVEIPGCPLHVAPYF	TSHB	81	P01222
PVAFSDYIHPVCLPD	F2	471	P00734
PDEIEYIFKPSCVPL	VEGFA	66	P15692
AVPHPRFYCVLSPEA	UBR4	926	Q5T4S7
DCPPAHTNRYIPLIV	ARHGAP21	1151	Q5T5U3
ESPPHVENYCLPEAI	TOPBP1	1476	Q92547
LILPPPVHVDYRAAC	GTF2H3	241	Q13889
LDDPIPQEYALFLCP	UBASH3A	66	P57075
EYLCLPAPQINDHSP	VLDLR	716	P98155
DDNYHIFCLLPPLPE	KDM5C	346	P41229