Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	epoxide hydrolase activity	AKR7A3 EPHX2 AKR7L	3.61e-07	11	27	3	GO:0004301
GeneOntologyMolecularFunction	hydrolase activity, acting on ether bonds	AKR7A3 EPHX2 AKR7L	6.25e-07	13	27	3	GO:0016801
GeneOntologyMolecularFunction	ether hydrolase activity	AKR7A3 EPHX2 AKR7L	6.25e-07	13	27	3	GO:0016803
GeneOntologyMolecularFunction	phenanthrene-9,10-epoxide hydrolase activity	AKR7A3 AKR7L	5.28e-06	3	27	2	GO:0019119
GeneOntologyMolecularFunction	phenanthrene-epoxide hydrolase activity	AKR7A3 AKR7L	5.28e-06	3	27	2	GO:0019118
GeneOntologyMolecularFunction	aldose reductase (NADPH) activity	AKR7A3 AKR7L	1.59e-04	14	27	2	GO:0004032
GeneOntologyMolecularFunction	alcohol dehydrogenase (NADP+) activity	AKR7A3 AKR7L	6.05e-04	27	27	2	GO:0008106
GeneOntologyMolecularFunction	aldo-keto reductase (NADPH) activity	AKR7A3 AKR7L	8.52e-04	32	27	2	GO:0004033
Domain	NADP_OxRdtase_dom	AKR7A3 AKR7L	2.91e-04	17	28	2	IPR023210
Domain	Aldo_ket_red	AKR7A3 AKR7L	2.91e-04	17	28	2	PF00248
Domain	Aldo/ket_red/Kv-b	AKR7A3 AKR7L	2.91e-04	17	28	2	IPR001395
Domain	Znf_FYVE_PHD	RAG2 CHD4 RPH3A	1.35e-03	147	28	3	IPR011011
Domain	ZF_PHD_2	RAG2 CHD4	8.88e-03	95	28	2	PS50016
Domain	ZF_PHD_1	RAG2 CHD4	9.06e-03	96	28	2	PS01359
Pathway	WP_AFLATOXIN_B1_METABOLISM	AKR7A3 AKR7L	3.47e-05	6	22	2	MM15846
Pubmed	[Purification of recombinant AKR7A5 protein and measurement of substrate specificity of AKR7A5 towards naphthoquinone and its derivatives].	AKR7A3 AKR7L	1.87e-06	3	28	2	22863590
Pubmed	Aldo-keto reductase 7A5 (AKR7A5) attenuates oxidative stress and reactive aldehyde toxicity in V79-4 cells.	AKR7A3 AKR7L	1.87e-06	3	28	2	24590062
Pubmed	AKR7A5 knockout promote acute liver injury by inducing inflammatory response, oxidative stress and apoptosis in mice.	AKR7A3 AKR7L	1.87e-06	3	28	2	39365156
Pubmed	Novel homodimeric and heterodimeric rat gamma-hydroxybutyrate synthases that associate with the Golgi apparatus define a distinct subclass of aldo-keto reductase 7 family proteins.	AKR7A3 AKR7L	1.87e-06	3	28	2	12071861
Pubmed	Mouse aldo-keto reductase AKR7A5 protects V79 cells against 4-hydroxynonenal-induced apoptosis.	AKR7A3 AKR7L	1.87e-06	3	28	2	16919859
Pubmed	Characterisation of a novel mouse liver aldo-keto reductase AKR7A5.	AKR7A3 AKR7L	1.87e-06	3	28	2	12123834
Pubmed	Aflatoxin B1 aldehyde reductase (AFAR) genes cluster at 1p35-1p36.1 in a region frequently altered in human tumour cells.	AKR7A3 AKR7L	3.75e-06	4	28	2	12879023
Pubmed	Malignant astrocytomas originate from neural stem/progenitor cells in a somatic tumor suppressor mouse model.	RAG2 NF1	9.36e-06	6	28	2	19111880
Pubmed	Identification of Lineage-Specific Transcription Factors That Prevent Activation of Hepatic Stellate Cells and Promote Fibrosis Resolution.	RAG2 NF1	1.31e-05	7	28	2	31982409
Pubmed	CHD4-regulated plasmin activation impacts lymphovenous hemostasis and hepatic vascular integrity.	FGB CHD4	4.10e-05	12	28	2	27140400
Pubmed	The mouse Rhl1 and Rhag genes: sequence, organization, expression, and chromosomal mapping.	AKR7A3 AKR7L	4.10e-05	12	28	2	10495887
Pubmed	Four paralogous protein 4.1 genes map to distinct chromosomes in mouse and human.	AKR7A3 AKR7L	1.18e-04	20	28	2	9828140
Pubmed	In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.	AKR7A3 FGB EPHX2 C1R MAN2B2 AKR7L	1.76e-04	1070	28	6	23533145
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	CHD4 NF1 ITSN1 PURB SHCBP1	3.46e-04	774	28	5	15302935
Pubmed	Identification of candidate alkylator-induced cancer susceptibility genes by whole genome scanning in mice.	FGB TBC1D21	4.09e-04	37	28	2	16707424
Cytoband	1p36.13	AKR7A3 AKR7L	5.41e-04	56	28	2	1p36.13
Cytoband	12p13	C1R CHD4	7.06e-04	64	28	2	12p13
Coexpression	DESCARTES_ORGANOGENESIS_HEPATOCYTES	FGB EPHX2 C1R FPGS AGMO KLB	1.81e-05	535	28	6	MM3635
Disease	kidney disease (implicated_via_orthology)	APOL4 KLB	6.47e-04	41	27	2	DOID:557 (implicated_via_orthology)
Disease	total cholesterol measurement, triglyceride measurement, low density lipoprotein cholesterol measurement, high density lipoprotein cholesterol measurement	NF1 RPH3A	9.23e-04	49	27	2	EFO_0004530, EFO_0004574, EFO_0004611, EFO_0004612
Disease	Non-alcoholic Fatty Liver Disease	RAG2 KLB	1.87e-03	70	27	2	C0400966
Disease	Nonalcoholic Steatohepatitis	RAG2 KLB	1.87e-03	70	27	2	C3241937
Disease	p-tau measurement	MTBP AGMO	1.98e-03	72	27	2	EFO_0004763
Disease	squamous cell lung carcinoma, family history of lung cancer	NF1 PURB	2.75e-03	85	27	2	EFO_0000708, EFO_0006953
Disease	reaction time measurement	COL24A1 TBC1D21 RPH3A PURB	2.86e-03	658	27	4	EFO_0008393
Disease	alcohol use disorder measurement, alcohol consumption measurement	NF1 KLB	3.56e-03	97	27	2	EFO_0007878, EFO_0009458
Disease	coronary artery disease (is_implicated_in)	FGB EPHX2	3.78e-03	100	27	2	DOID:3393 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
GKQPVGRFFGTQWAE	AKR7L	216	Q8NHP1
GKQPVGRFFGNTWAE	AKR7A3	216	O95154
FFNKFSVIFKGPGWG	AGMO	291	Q6ZNB7
PGWTVAGQFQEKKRF	APOL4	21	Q9BPW4
QNGGWENGFVKKFEP	BCL2A1	136	Q16548
GGQKAKMGNFPWQVF	C1R	466	P00736
GQVFFFGQKGWPKRS	RAG2	26	P55895
FGKPNKRRGFSAGLW	HDGFL1	66	Q5TGJ6
DFGRKWDPYKQGFGN	FGB	291	P02675
VQQFKKSGFRGPLNW	EPHX2	451	P34913
FTPGGFVNRFQKWFQ	AWAT2	236	Q6E213
FGEVQGQKGWFPKSY	ITSN1	951	Q15811
NRSGFYWNGVAVFPK	MAN2B2	226	Q9Y2E5
WQKGGIFKQGVPAFT	FPGS	241	Q05932
FPKNFFWGIGTGALQ	KLB	81	Q86Z14
GAKWREFSTNNPFKG	CHD4	206	Q14839
RDFFWKTGNKIGFKP	DERA	241	Q9Y315
NAITVPFKAWGKFGG	PURB	256	Q96QR8
GGIPGSKKWFFAVQA	MTBP	71	Q96DY7
FPGQSSFLWQRGRKF	TOR1AIP2	266	Q8NFQ8
KRSGAWFFKGFPKQV	RPH3A	151	Q9Y2J0
KGKGAGAVQSLFPWF	TBC1D21	226	Q8IYX1
FVGIVGNQFKWNGKG	SHCBP1	651	Q8NEM2
QEKAGWFRFPKLGFS	AHNAK2	5691	Q8IVF2
GFKGWNGQIFKVNTL	COL24A1	1641	Q17RW2
RKGGTFKGFPDWKSF	SPATA31D1	71	Q6ZQQ2
FKCKGTFVGHQGPVW	TRAF7	386	Q6Q0C0
FGFNGLWRFAGPFSK	NF1	2706	P21359