Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
MousePheno	abnormal cochlear hair cell morphology	EPS8 FAT4 ESR2 LAMA2 KCNQ4 NFKB1 SLITRK6 BSN	1.79e-05	202	79	8	MP:0002622
MousePheno	abnormal cochlear sensory epithelium morphology	EPS8 FAT4 ESR2 LAMA2 KCNQ4 NFKB1 SLITRK6 BSN	2.14e-05	207	79	8	MP:0003308
MousePheno	abnormal organ of Corti morphology	EPS8 FAT4 ESR2 LAMA2 KCNQ4 NFKB1 SLITRK6 BSN	2.29e-05	209	79	8	MP:0000042
MousePheno	abnormal hair cell morphology	EPS8 FAT4 ESR2 LAMA2 KCNQ4 NFKB1 SLITRK6 BSN	2.72e-05	214	79	8	MP:0000045
MousePheno	abnormal mechanoreceptor morphology	EPS8 FAT4 ESR2 LAMA2 KCNQ4 NFKB1 SLITRK6 BSN	4.68e-05	231	79	8	MP:0000972
MousePheno	abnormal cochlear labyrinth morphology	EPS8 FAT4 ESR2 LAMA2 KCNQ4 NFKB1 SLITRK6 BSN	5.29e-05	235	79	8	MP:0004426
MousePheno	abnormal scala media morphology	EPS8 FAT4 ESR2 LAMA2 KCNQ4 NFKB1 SLITRK6 BSN	5.29e-05	235	79	8	MP:0003169
MousePheno	abnormal cochlea morphology	EPS8 FAT4 ESR2 LAMA2 KCNQ4 NFKB1 SLITRK6 BSN	7.72e-05	248	79	8	MP:0000031
MousePheno	abnormal membranous labyrinth morphology	EPS8 FAT4 ESR2 LAMA2 KCNQ4 NFKB1 SLITRK6 BSN	1.13e-04	262	79	8	MP:0000035
MousePheno	skeletal muscle fiber degeneration	FLNC SGCB RYR1	2.15e-04	21	79	3	MP:0009412
MousePheno	decreased skeletal muscle fiber number	FLNC LAMA2 RYR1	2.15e-04	21	79	3	MP:0009406
MousePheno	muscle degeneration	FLNC SGCB LAMA2 RYR1	2.59e-04	55	79	4	MP:0000749
MousePheno	abnormal inner ear morphology	EPS8 FAT4 ESR2 LAMA2 KCNQ4 NFKB1 SLITRK6 BSN	3.05e-04	303	79	8	MP:0000026
Domain	MULTICOPPER_OXIDASE2	CP HEPH	8.32e-05	3	99	2	PS00080
Domain	Cu-oxidase	CP HEPH	8.32e-05	3	99	2	PF00394
Domain	Cu-oxidase	CP HEPH	8.32e-05	3	99	2	IPR001117
Domain	Cu-oxidase_2	CP HEPH	1.66e-04	4	99	2	IPR011706
Domain	Cu-oxidase_2	CP HEPH	1.66e-04	4	99	2	PF07731
Domain	ACTININ_2	FLNC CLMN MACF1	2.37e-04	23	99	3	PS00020
Domain	ACTININ_1	FLNC CLMN MACF1	2.37e-04	23	99	3	PS00019
Domain	Actinin_actin-bd_CS	FLNC CLMN MACF1	2.37e-04	23	99	3	IPR001589
Domain	Cu-oxidase_3	CP HEPH	2.75e-04	5	99	2	IPR011707
Domain	MULTICOPPER_OXIDASE1	CP HEPH	2.75e-04	5	99	2	PS00079
Domain	Cu_oxidase_CS	CP HEPH	2.75e-04	5	99	2	IPR033138
Domain	Cu-oxidase_3	CP HEPH	2.75e-04	5	99	2	PF07732
Domain	CH	FLNC SPECC1 CLMN MACF1	3.92e-04	65	99	4	SM00033
Domain	Cu_oxidase_Cu_BS	CP HEPH	4.11e-04	6	99	2	IPR002355
Domain	CH	FLNC SPECC1 CLMN MACF1	5.21e-04	70	99	4	PF00307
Domain	-	FLNC SPECC1 CLMN MACF1	5.50e-04	71	99	4	1.10.418.10
Domain	CH	FLNC SPECC1 CLMN MACF1	6.11e-04	73	99	4	PS50021
Domain	CH-domain	FLNC SPECC1 CLMN MACF1	6.77e-04	75	99	4	IPR001715
Domain	PTB	EPS8 TNS1	7.63e-04	8	99	2	IPR013625
Domain	PTB	EPS8 TNS1	7.63e-04	8	99	2	PF08416
Domain	DUF1220	NBPF4 NBPF6	9.77e-04	9	99	2	SM01148
Domain	LAM_G_DOMAIN	FAT4 LAMA2 FAT1	1.07e-03	38	99	3	PS50025
Domain	ConA-like_dom	FAT4 ZAN LAMA2 RYR1 FAT1 HERC1	1.10e-03	219	99	6	IPR013320
Domain	PTB	EPS8 TNS1 ANKS1A	1.24e-03	40	99	3	SM00462
Domain	Laminin_G_2	FAT4 LAMA2 FAT1	1.24e-03	40	99	3	PF02210
Domain	PTB/PI_dom	EPS8 TNS1 ANKS1A	1.33e-03	41	99	3	IPR006020
Domain	DUF1220	NBPF4 NBPF6	1.48e-03	11	99	2	PF06758
Domain	NBPF_dom	NBPF4 NBPF6	1.48e-03	11	99	2	IPR010630
Domain	NBPF	NBPF4 NBPF6	1.48e-03	11	99	2	PS51316
Domain	LamG	FAT4 LAMA2 FAT1	1.63e-03	44	99	3	SM00282
Domain	-	CP HEPH	2.43e-03	14	99	2	2.60.40.420
Domain	Post-SET_dom	KMT2C SETD2	3.18e-03	16	99	2	IPR003616
Domain	PostSET	KMT2C SETD2	3.18e-03	16	99	2	SM00508
Domain	POST_SET	KMT2C SETD2	3.18e-03	16	99	2	PS50868
Domain	Laminin_G	FAT4 LAMA2 FAT1	3.61e-03	58	99	3	IPR001791
Domain	-	EPS8 ARHGEF28 SH2B2 PLEKHH3 IQSEC1 TNS1 ANKS1A	4.78e-03	391	99	7	2.30.29.30
Pathway	WP_TOLLLIKE_RECEPTOR_SIGNALING_RELATED_TO_MYD88	TICAM2 NFKB1 TLR3 MAPK1	2.69e-05	31	80	4	M39573
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	AARS1 SORBS2 HIVEP2 ARHGEF28 RALGAPB ARHGAP17 PRAG1 SPECC1 ALMS1 CLMN STARD9 N4BP2 SEC16A IQSEC1 MACF1 SSH2 EIF4G3 ANKS1A	4.69e-11	861	100	18	36931259
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	FLNC HIVEP2 SZT2 PEX6 ARHGAP17 ANKHD1 PRAG1 SH2B2 RNF43 RYR1 PLEKHH3 KMT2C FASN FAT1 KANSL1 DUSP16 SEC16A DISP2 HERC1	3.45e-10	1105	100	19	35748872
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	EPS8 FLNC CACNB4 SORBS2 MARK1 PKP4 OGDH SPECC1 GDA FASN CLMN SEC16A IQSEC1 PACS2 MACF1 ACTL6B SSH2 MAPK1 BSN EIF4G3 TNS1	6.28e-10	1431	100	21	37142655
Pubmed	A human MAP kinase interactome.	ZNF823 FLNC HIVEP2 ARHGAP17 MUC12 KMT2C KANSL1 N4BP2 DUSP16 MACF1 MAPK1 TNS1	1.67e-08	486	100	12	20936779
Pubmed	Comprehensive identification of phosphorylation sites in postsynaptic density preparations.	CACNA1E CACNB4 MARK1 PKP4 CLMN IQSEC1 MACF1 BSN	3.69e-07	231	100	8	16452087
Pubmed	Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.	CACNA1E ANKHD1 KMT2C ALMS1 XIRP2 STARD9 IQSEC1 BSN	3.94e-07	233	100	8	37704626
Pubmed	The forkhead genes, Foxc1 and Foxc2, regulate paraxial versus intermediate mesoderm cell fate.	WT1 MAPK1 FOXF1 SMAD9	5.46e-07	23	100	4	15196959
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	CACNA1E CACNB4 SORBS2 PKP4 GDA N4BP2 SEC16A IQSEC1 MACF1 SSH2 MAPK1 BSN TNS1 ANKS1A	6.88e-07	963	100	14	28671696
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	CACNA1E SORBS2 PKP4 PRAG1 GDA IQSEC1 MACF1 MAPK1	1.61e-06	281	100	8	28706196
Pubmed	Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.	SZT2 SPECC1 RYR1 KMT2C TLR3 CAPRIN2 BSN	2.47e-06	208	100	7	33230847
Pubmed	A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.	EPS8 DSC3 MARK1 PKP4 RALGAPB SPECC1 SEC16A MACF1 MPP7	3.69e-06	421	100	9	36976175
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	RBL1 PKP4 PEX6 ANKHD1 INO80D RNF43 SETD2 FAT1 ALMS1 CAPRIN2 SEC16A IQSEC1 MACF1 ACTL6B	3.84e-06	1116	100	14	31753913
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	RALGAPB HEPH KMT2C ALMS1 SEC16A MACF1 HPS5	4.15e-06	225	100	7	12168954
Pubmed	Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.	FLG EPS8 AARS1 PLEKHH3 KMT2C ZNF668 FAT1 CLMN NFKB1 SSH2 FOXF1	4.89e-06	689	100	11	36543142
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	EPS8 SORBS2 MARK1 PKP4 RALGAPB ALMS1 SEC16A MPP7 ANKS1A	5.87e-06	446	100	9	24255178
Pubmed	Impact of WIN site inhibitor on the WDR5 interactome.	SPECC1 KMT2C KANSL1 IQSEC1	7.28e-06	43	100	4	33472061
Pubmed	Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.	CACNA1E CACNB4 PKP4 SPECC1 IQSEC1 MACF1 BSN EIF4G3	7.59e-06	347	100	8	17114649
Pubmed	Leukemia virus long terminal repeat activates NFkappaB pathway by a TLR3-dependent mechanism.	NFKB1 TLR3	8.18e-06	2	100	2	16289658
Pubmed	Amentoflavone Effectively Blocked the Tumor Progression of Glioblastoma via Suppression of ERK/NF- κ B Signaling Pathway.	NFKB1 MAPK1	8.18e-06	2	100	2	31096773
Pubmed	Activation of the wt1 Wilms' tumor suppressor gene by NF-kappaB.	WT1 NFKB1	8.18e-06	2	100	2	9572484
Pubmed	Poxviral regulation of the host NF-kappaB response: the vaccinia virus M2L protein inhibits induction of NF-kappaB activation via an ERK2 pathway in virus-infected human embryonic kidney cells.	NFKB1 MAPK1	8.18e-06	2	100	2	16912315
Pubmed	Deletion of hephaestin and ceruloplasmin induces a serious systemic iron deficiency and disrupts iron homeostasis.	CP HEPH	8.18e-06	2	100	2	30060949
Pubmed	6β-Hydroxytestosterone, a Cytochrome P450 1B1-Testosterone-Metabolite, Mediates Angiotensin II-Induced Renal Dysfunction in Male Mice.	CYP1B1 NFKB1	8.18e-06	2	100	2	26928804
Pubmed	Ferroxidase hephaestin's cell-autonomous role in the retinal pigment epithelium.	CP HEPH	8.18e-06	2	100	2	22342521
Pubmed	Inflammatory and catabolic signalling in intervertebral discs: the roles of NF-κB and MAP kinases.	NFKB1 MAPK1	8.18e-06	2	100	2	22354461
Pubmed	Inflammatory response and MAPK and NF-κB pathway activation induced by natural street rabies virus infection in the brain tissues of dogs and humans.	NFKB1 MAPK1	8.18e-06	2	100	2	33081802
Pubmed	The oral iron chelator deferiprone protects against iron overload-induced retinal degeneration.	CP HEPH	8.18e-06	2	100	2	21051716
Pubmed	Submersion and hypoxia inhibit alveolar epithelial Na+ transport through ERK/NF-κB signaling pathway.	NFKB1 MAPK1	8.18e-06	2	100	2	37095538
Pubmed	Cardiomyocyte Maturation Requires TLR3 Activated Nuclear Factor Kappa B.	NFKB1 TLR3	8.18e-06	2	100	2	29676038
Pubmed	Grape seed proanthocyanidin extract protects human lens epithelial cells from oxidative stress via reducing NF-кB and MAPK protein expression.	NFKB1 MAPK1	8.18e-06	2	100	2	21264233
Pubmed	Cp/Heph mutant mice have iron-induced neurodegeneration diminished by deferiprone.	CP HEPH	8.18e-06	2	100	2	26303407
Pubmed	Ablation of hephaestin and ceruloplasmin results in iron accumulation in adipocytes and type 2 diabetes.	CP HEPH	8.18e-06	2	100	2	29355933
Pubmed	Hephaestin and ceruloplasmin facilitate iron metabolism in the mouse kidney.	CP HEPH	8.18e-06	2	100	2	27991585
Pubmed	Advanced glycation end products promote triple negative breast cancer cells via ERK and NF-κB pathway.	NFKB1 MAPK1	8.18e-06	2	100	2	29196260
Pubmed	MAPK1 Mediates MAM Disruption and Mitochondrial Dysfunction in Diabetic Kidney Disease via the PACS-2-Dependent Mechanism.	PACS2 MAPK1	8.18e-06	2	100	2	38169625
Pubmed	Fatty acid synthase/oxidized low-density lipoprotein as metabolic oncogenes linking obesity to colon cancer via NF-kappa B in Egyptians.	FASN NFKB1	8.18e-06	2	100	2	25173531
Pubmed	TLR3 ligand induces NF-{kappa}B activation and various fates of multiple myeloma cells depending on IFN-{alpha} production.	NFKB1 TLR3	8.18e-06	2	100	2	19299748
Pubmed	Erk regulation of actin capping and bundling by Eps8 promotes cortex tension and leader bleb-based migration.	EPS8 MAPK1	8.18e-06	2	100	2	26163656
Pubmed	Ceruloplasmin/hephaestin knockout mice model morphologic and molecular features of AMD.	CP HEPH	8.18e-06	2	100	2	18326691
Pubmed	Hephaestin and ceruloplasmin play distinct but interrelated roles in iron homeostasis in mouse brain.	CP HEPH	8.18e-06	2	100	2	25788583
Pubmed	Disruption of ceruloplasmin and hephaestin in mice causes retinal iron overload and retinal degeneration with features of age-related macular degeneration.	CP HEPH	8.18e-06	2	100	2	15365174
Pubmed	Ceruloplasmin and hephaestin jointly protect the exocrine pancreas against oxidative damage by facilitating iron efflux.	CP HEPH	8.18e-06	2	100	2	29883959
Pubmed	Phosphatidylserine inhibits NFκB and p38 MAPK activation in human monocyte derived dendritic cells.	NFKB1 MAPK1	8.18e-06	2	100	2	21628073
Pubmed	Activation of ERK induces phosphorylation of MAPK phosphatase-7, a JNK specific phosphatase, at Ser-446.	DUSP16 MAPK1	8.18e-06	2	100	2	12794087
Pubmed	Iron induced oxidative damage as a potential factor in age-related macular degeneration: the Cogan Lecture.	CP HEPH	8.18e-06	2	100	2	17065470
Pubmed	Multi-copper ferroxidase deficiency leads to iron accumulation and oxidative damage in astrocytes and oligodendrocytes.	CP HEPH	8.18e-06	2	100	2	31263155
Pubmed	SORBS2 and TLR3 induce premature senescence in primary human fibroblasts and keratinocytes.	SORBS2 TLR3	8.18e-06	2	100	2	24165198
Pubmed	Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes.	ZAN SH2B2 ACTL6B	8.20e-06	14	100	3	9799793
Pubmed	A novel isoform of Vinexin, Vinexin gamma, regulates Sox9 gene expression through activation of MAPK cascade in mouse fetal gonad.	SORBS2 WT1 MAPK1	8.20e-06	14	100	3	15836771
Pubmed	Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression.	TICAM2 NFKB1 TLR3	8.20e-06	14	100	3	19570822
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	FLNC SGCB LAMA2 ZNF302 RYR1 ALMS1 XIRP2 CLMN MACF1	1.39e-05	497	100	9	23414517
Pubmed	FAT4 Fine-Tunes Kidney Development by Regulating RET Signaling.	FAT4 WT1 MAPK1	1.82e-05	18	100	3	30853441
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	SORBS2 RALGAPB KANSL1 STARD9 SEC16A PACS2 MACF1 DISP2	2.39e-05	407	100	8	12693553
Pubmed	Echinocystic acid inhibits RANKL-induced osteoclastogenesis by regulating NF-κB and ERK signaling pathways.	NFKB1 MAPK1	2.45e-05	3	100	2	27349866
Pubmed	Protective mechanism of epigallocatechin-3-gallate against Helicobacter pylori-induced gastric epithelial cytotoxicity via the blockage of TLR-4 signaling.	NFKB1 MAPK1	2.45e-05	3	100	2	15610077
Pubmed	RNF25 promotes gefitinib resistance in EGFR-mutant NSCLC cells by inducing NF-κB-mediated ERK reactivation.	NFKB1 MAPK1	2.45e-05	3	100	2	29789542
Pubmed	Thrombospondin-4 deletion does not exacerbate muscular dystrophy in β-sarcoglycan-deficient and laminin α2 chain-deficient mice.	SGCB LAMA2	2.45e-05	3	100	2	38926599
Pubmed	Advanced glycation end products decrease collagen I levels in fibroblasts from the vaginal wall of patients with POP via the RAGE, MAPK and NF-κB pathways.	NFKB1 MAPK1	2.45e-05	3	100	2	28849117
Pubmed	Electronegative L5-LDL induces the production of G-CSF and GM-CSF in human macrophages through LOX-1 involving NF-κB and ERK2 activation.	NFKB1 MAPK1	2.45e-05	3	100	2	29078142
Pubmed	Aromatase, CYP1B1 and fatty acid synthase expression in breast tumors of BRCA1 mutation carriers.	CYP1B1 FASN	2.45e-05	3	100	2	19083124
Pubmed	Helminth cysteine proteases inhibit TRIF-dependent activation of macrophages via degradation of TLR3.	TICAM2 TLR3	2.45e-05	3	100	2	19923225
Pubmed	Ferroportin and exocytoplasmic ferroxidase activity are required for brain microvascular endothelial cell iron efflux.	CP HEPH	2.45e-05	3	100	2	23640881
Pubmed	Dengue virus serotype 2 blocks extracellular signal-regulated kinase and nuclear factor-κB activation to downregulate cytokine production.	NFKB1 MAPK1	2.45e-05	3	100	2	22927911
Pubmed	ERβ regulation of NF-kB activation in prostate cancer is mediated by HIF-1.	ESR2 NFKB1	2.45e-05	3	100	2	26450901
Pubmed	Cyp1B1 expression promotes angiogenesis by suppressing NF-κB activity.	CYP1B1 NFKB1	2.45e-05	3	100	2	24088896
Pubmed	Thioredoxin-2 impacts the inflammatory response via suppression of NF-κB and MAPK signaling in sepsis shock.	NFKB1 MAPK1	2.45e-05	3	100	2	32057359
Pubmed	Inhibition of MAPK and NF-κB signaling pathways alleviate carbon tetrachloride (CCl4)-induced liver fibrosis in Toll-like receptor 5 (TLR5) deficiency mice.	NFKB1 MAPK1	2.45e-05	3	100	2	26845355
Pubmed	[Ceruloplasmin, hephaestin and zyklopen: the three multicopper oxidases important for human iron metabolism].	CP HEPH	2.45e-05	3	100	2	24988611
Pubmed	Neither human hephaestin nor ceruloplasmin forms a stable complex with transferrin.	CP HEPH	2.45e-05	3	100	2	18022819
Pubmed	Toll-Like Receptor 3-TRIF Pathway Activation by Neospora caninum RNA Enhances Infection Control in Mice.	TICAM2 TLR3	2.45e-05	3	100	2	30670552
Pubmed	Analysis of genes induced by Sendai virus infection of mutant cell lines reveals essential roles of interferon regulatory factor 3, NF-kappaB, and interferon but not toll-like receptor 3.	NFKB1 TLR3	2.45e-05	3	100	2	15767394
Pubmed	Spatial Clustering of de Novo Missense Mutations Identifies Candidate Neurodevelopmental Disorder-Associated Genes.	PACS2 ACTL6B	2.45e-05	3	100	2	28867141
Pubmed	Severe Iron Metabolism Defects in Mice With Double Knockout of the Multicopper Ferroxidases Hephaestin and Ceruloplasmin.	CP HEPH	2.45e-05	3	100	2	30182051
Pubmed	Gambogic acid synergistically potentiates cisplatin-induced apoptosis in non-small-cell lung cancer through suppressing NF-κB and MAPK/HO-1 signalling.	NFKB1 MAPK1	2.45e-05	3	100	2	24300974
Pubmed	β-Catenin and NF-κB co-activation triggered by TLR3 stimulation facilitates stem cell-like phenotypes in breast cancer.	NFKB1 TLR3	2.45e-05	3	100	2	25257174
Pubmed	Reverse signaling initiated from GITRL induces NF-kappaB activation through ERK in the inflammatory activation of macrophages.	NFKB1 MAPK1	2.45e-05	3	100	2	17602748
Pubmed	Activation of Toll-like receptor 3 augments myofibroblast differentiation.	NFKB1 TLR3	2.45e-05	3	100	2	18988918
Pubmed	Iron promotes oxidative cell death caused by bisretinoids of retina.	CP HEPH	2.45e-05	3	100	2	29686088
Pubmed	Urotensin II increases foam cell formation by repressing ABCA1 expression through the ERK/NF-κB pathway in THP-1 macrophages.	NFKB1 MAPK1	2.45e-05	3	100	2	25223800
Pubmed	Subcellular localization determines the protective effects of activated ERK2 against distinct apoptogenic stimuli in myeloid leukemia cells.	NFKB1 MAPK1	2.45e-05	3	100	2	15173174
Pubmed	Filamin C is a highly dynamic protein associated with fast repair of myofibrillar microdamage.	FLNC XIRP2	2.45e-05	3	100	2	27206985
Pubmed	Downregulating p22phox ameliorates inflammatory response in Angiotensin II-induced oxidative stress by regulating MAPK and NF-κB pathways in ARPE-19 cells.	NFKB1 MAPK1	2.45e-05	3	100	2	26415877
Pubmed	Double-stranded RNA upregulates the expression of inflammatory mediators in human aortic valve cells through the TLR3-TRIF-noncanonical NF-κB pathway.	NFKB1 TLR3	2.45e-05	3	100	2	28052863
Pubmed	Oncogene KRAS activates fatty acid synthase, resulting in specific ERK and lipid signatures associated with lung adenocarcinoma.	FASN MAPK1	2.45e-05	3	100	2	28400509
Pubmed	A combined laser microdissection and mass spectrometry approach reveals new disease relevant proteins accumulating in aggregates of filaminopathy patients.	FLNC XIRP2	2.45e-05	3	100	2	23115302
Pubmed	Long Non-Coding RNA-GDA-1 Promotes Keratinocyte Proliferation and Psoriasis Inflammation by Regulating the STAT3/NF-κB Signaling Pathway via Forkhead Box M1.	GDA NFKB1	2.45e-05	3	100	2	36943641
Pubmed	Polymorphisms in estrogen-metabolizing and estrogen receptor genes and the risk of developing breast cancer among a cohort of women with benign breast disease.	CYP1B1 ESR2	2.45e-05	3	100	2	16808847
Pubmed	Filaggrin knockdown and Toll-like receptor 3 (TLR3) stimulation enhanced the production of thymic stromal lymphopoietin (TSLP) from epidermal layers.	FLG TLR3	2.45e-05	3	100	2	21255094
Pubmed	Toll-like receptor 3 signalling up-regulates expression of the HIV co-receptor G-protein coupled receptor 15 on human CD4+ T cells.	GPR15 TLR3	2.45e-05	3	100	2	24558379
Pubmed	Myeloid-specific GPCR kinase-2 negatively regulates NF-κB1p105-ERK pathway and limits endotoxemic shock in mice.	NFKB1 MAPK1	2.45e-05	3	100	2	20717897
Pubmed	Diallyl sulfide induces apoptosis in Colo 320 DM human colon cancer cells: involvement of caspase-3, NF-kappaB, and ERK-2.	NFKB1 MAPK1	2.45e-05	3	100	2	18256791
Pubmed	Andrographolide exerted its antimicrobial effects by upregulation of human β-defensin-2 induced through p38 MAPK and NF-κB pathway in human lung epithelial cells.	NFKB1 MAPK1	2.45e-05	3	100	2	22537555
Pubmed	Conditional knockout of hephaestin in the neural retina disrupts retinal iron homeostasis.	CP HEPH	2.45e-05	3	100	2	35271829
Pubmed	GPR34 Knockdown Relieves Cognitive Deficits and Suppresses Neuroinflammation in Alzheimer's Disease via the ERK/NF-κB Signal.	NFKB1 MAPK1	2.45e-05	3	100	2	37557947
Pubmed	Phosphorylation of TPL-2 on serine 400 is essential for lipopolysaccharide activation of extracellular signal-regulated kinase in macrophages.	NFKB1 MAPK1	2.45e-05	3	100	2	17709378
Pubmed	Loss of dystrophin and β-sarcoglycan significantly exacerbates the phenotype of laminin α2 chain-deficient animals.	SGCB LAMA2	2.45e-05	3	100	2	24393714
Pubmed	Phosphodiesterase inhibitors suppress Lactobacillus casei cell-wall-induced NF-κB and MAPK activations and cell proliferation through protein kinase A--or exchange protein activated by cAMP-dependent signal pathway.	NFKB1 MAPK1	2.45e-05	3	100	2	22645447
Pubmed	Analysis of interaction partners for eukaryotic translation elongation factor 1A M-domain by functional proteomics.	SORBS2 XIRP2 MACF1	2.54e-05	20	100	3	21689717
Pubmed	Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.	CACNA1E SORBS2 MARK1 SPECC1 STARD9 IQSEC1 MACF1 TUBAL3	3.53e-05	430	100	8	32581705
Pubmed	Stromal Fat4 acts non-autonomously with Dchs1/2 to restrict the nephron progenitor pool.	FAT4 WT1 FAT1	4.47e-05	24	100	3	26116661
Interaction	YWHAG interactions	AARS1 SORBS2 HIVEP2 ARHGEF28 MARK1 ESR2 RALGAPB ARHGAP17 PRAG1 SPECC1 ALMS1 CLMN STARD9 N4BP2 DUSP16 SEC16A IQSEC1 PACS2 MACF1 SSH2 EIF4G3 ANKS1A	1.27e-07	1248	99	22	int:YWHAG
Interaction	YWHAH interactions	SORBS2 HIVEP2 ARHGEF28 MARK1 ESR2 RALGAPB ARHGAP17 PRAG1 SPECC1 ALMS1 CLMN STARD9 DUSP16 SEC16A PACS2 MACF1 SSH2 HERC1 EIF4G3 ANKS1A	3.33e-07	1102	99	20	int:YWHAH
Interaction	C2CD4B interactions	FAT4 SETD2 FAT1 MACF1 HERC1	2.41e-06	44	99	5	int:C2CD4B
Interaction	KCTD13 interactions	EPS8 FLNC CACNB4 SORBS2 MARK1 PKP4 OGDH SPECC1 GDA FASN CLMN SEC16A IQSEC1 PACS2 MACF1 ACTL6B SSH2 MAPK1 BSN EIF4G3 TNS1	3.28e-06	1394	99	21	int:KCTD13
Interaction	KCNA3 interactions	DSC3 SZT2 SPECC1 RYR1 GMPS KMT2C FASN TLR3 CAPRIN2 SEC16A MACF1 BSN EIF4G3 MPP7 ANKS1A	2.20e-05	871	99	15	int:KCNA3
Interaction	DUSP16 interactions	SZT2 ALMS1 N4BP2 DUSP16 SEC16A MAPK1 HPS5 TUBAL3	2.22e-05	237	99	8	int:DUSP16
Interaction	CNOT2 interactions	ESR2 ANKHD1 FASN ALMS1 N4BP2 NFKB1 SEC16A	2.80e-05	178	99	7	int:CNOT2
Interaction	HPS5 interactions	ESR2 PHKG2 DUSP16 HPS5	2.86e-05	36	99	4	int:HPS5
Interaction	TOP3B interactions	FLNC HIVEP2 SZT2 PEX6 ARHGAP17 ANKHD1 PRAG1 SH2B2 RNF43 RYR1 PLEKHH3 KMT2C FASN FAT1 KANSL1 DUSP16 SEC16A DISP2 HERC1	8.58e-05	1470	99	19	int:TOP3B
Interaction	C6orf141 interactions	EPS8 FLNC ANKHD1 ALMS1 IQSEC1	9.06e-05	92	99	5	int:C6orf141
Interaction	CNOT6L interactions	ESR2 N4BP2 NFKB1 TLR3 SEC16A	9.54e-05	93	99	5	int:CNOT6L
Interaction	DCANP1 interactions	FAT4 FAT1 BOLL	1.05e-04	19	99	3	int:DCANP1
Interaction	YWHAQ interactions	SORBS2 HIVEP2 ARHGEF28 MARK1 ESR2 SPECC1 RNF43 FASN STARD9 NFKB1 DUSP16 PACS2 MACF1 SSH2 SMAD9 ANKS1A	1.05e-04	1118	99	16	int:YWHAQ
Cytoband	7q22	ZAN MUC12 SH2B2 ACTL6B	1.48e-06	38	100	4	7q22
Cytoband	13q12-q14	USPL1 SMAD9	1.41e-05	3	100	2	13q12-q14
Cytoband	4q35	FAT1 TLR3	4.84e-04	15	100	2	4q35
Cytoband	Ensembl 112 genes in cytogenetic band chr7q22	ZAN MUC12 SH2B2 ACTL6B	1.38e-03	219	100	4	chr7q22
Cytoband	Ensembl 112 genes in cytogenetic band chr4q35	SORBS2 FAT1 TLR3	2.18e-03	117	100	3	chr4q35
GeneFamily	Cadherin related	FAT4 FAT1	1.72e-03	17	66	2	24
GeneFamily	Neuroblastoma breakpoint family	NBPF4 NBPF6	3.16e-03	23	66	2	662
GeneFamily	Calcium voltage-gated channel subunits	CACNA1E CACNB4	4.03e-03	26	66	2	253
GeneFamily	Calcium voltage-gated channel subunits\|Membrane associated guanylate kinases	CACNB4 MPP7	4.03e-03	26	66	2	904
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF823 HIVEP2 ZBTB20 WT1 ZNF302 ZNF668 ZNF433 ZNF44	4.47e-03	718	66	8	28
Coexpression	RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_DN	SORBS2 HIVEP2 ZBTB20 PKP4 PRAG1 INO80D CES2 SETD2 KANSL1 ALMS1 CLMN HERC1 TNS1 SMAD9 ANKS1A	3.62e-07	807	99	15	M16651
Coexpression	LAKE_ADULT_KIDNEY_C4_PROXIMAL_TUBULE_EPITHELIAL_CELLS_S2	EPS8 SORBS2 ZBTB20 KANSL1 SSH2 EIF4G3	5.63e-05	176	99	6	M39223
Coexpression	GSE27241_WT_VS_RORGT_KO_TH17_POLARIZED_CD4_TCELL_TREATED_WITH_DIGOXIN_UP	KMT2C SETD2 FASN KANSL1 MACF1 HERC1	6.37e-05	180	99	6	M8239
Coexpression	GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN	EPS8 ZBTB20 SGCB MARK1 PKP4 ANKHD1 PRAG1 SPECC1 KANSL1 NKD1 ALMS1 CLMN PACS2 TNS1	6.73e-05	1102	99	14	M2369
Coexpression	XIE_TRASTUZUMAB_CARDIOTOXICITY_MMU_MIR_669C_3P_GENES	ZNF823 INO80D CLMN EIF4G3 TNS1 ZNF44	6.98e-05	183	99	6	MM17506
Coexpression	GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN	EPS8 ZBTB20 SGCB MARK1 PKP4 ANKHD1 PRAG1 SPECC1 KANSL1 NKD1 ALMS1 CLMN PACS2 TNS1	8.31e-05	1124	99	14	MM1070
Coexpression	GSE3982_MEMORY_CD4_TCELL_VS_TH1_UP	RALGAPB SETD2 CAPRIN2 MACF1 MAPK1 HERC1	1.05e-04	197	99	6	M5378
Coexpression	GSE36476_CTRL_VS_TSST_ACT_40H_MEMORY_CD4_TCELL_OLD_UP	AMT ZBTB20 TLR3 IQSEC1 MROH7 USPL1	1.08e-04	198	99	6	M5299
Coexpression	GSE29618_PRE_VS_DAY7_FLU_VACCINE_MDC_DN	SLC4A3 IQSEC1 MACF1 HERC1 EIF4G3 ANKS1A	1.08e-04	198	99	6	M4981
Coexpression	OVSYANNIKOVA_PBMC_FLUARIX_AGE_50_74YO_COMMON_WITH_BOTH_HAI_AND_VNA_28DY_VS_3DY_USED_IN_HAI_AND_VNA_RESPONSE_MODELS_UP	OGDH FASN TLR3	1.13e-04	25	99	3	M40987
Coexpression	GSE24634_TEFF_VS_TCONV_DAY7_IN_CULTURE_DN	CYP1B1 LILRA2 ARHGAP17 PHKG2 ZNF668 TNS1	1.14e-04	200	99	6	M4624
Coexpression	GSE360_L_MAJOR_VS_B_MALAYI_LOW_DOSE_DC_DN	ZBTB20 RBL1 OGDH SETD2 FASN TLR3	1.14e-04	200	99	6	M5212
Coexpression	GSE17721_0.5H_VS_4H_CPG_BMDC_DN	SGCB RBL1 PKP4 CP NFKB1 DUSP16	1.14e-04	200	99	6	M4125
Coexpression	XIE_TRASTUZUMAB_CARDIOTOXICITY_MMU_MIR_3095_3P_GENES	ZNF823 FLNC CLMN ZNF44	1.22e-04	67	99	4	MM17499
CoexpressionAtlas	DevelopingGonad_e18.5_epididymis_emap-13166_top-relative-expression-ranked_1000	CYP1B1 SORBS2 ZBTB20 PKP4 LAMA2 CP GMPS KMT2C KANSL1 CLMN STARD9 SLITRK6 HERC1 TNS1 MPP7	3.75e-06	799	98	15	gudmap_developingGonad_e18.5_epididymis_1000
CoexpressionAtlas	DevelopingGonad_e18.5_epididymis_emap-13166_k-means-cluster#3_top-relative-expression-ranked_1000	CYP1B1 SORBS2 PKP4 KANSL1 CLMN STARD9 SLITRK6 MPP7	4.79e-05	281	98	8	gudmap_developingGonad_e18.5_epididymis_1000_k3
CoexpressionAtlas	DevelopingLowerUrinaryTract_P1_bladder_J_emap-30374_top-relative-expression-ranked_1000	EPS8 FLNC CACNB4 SORBS2 HIVEP2 ZBTB20 GDA KANSL1 TLR3 SLITRK6 TNS1 FOXF1 MPP7	5.46e-05	772	98	13	gudmap_developingLowerUrinaryTract_P1_bladder_1000_J
CoexpressionAtlas	DevelopingGonad_P2_epididymis_emap-30199_top-relative-expression-ranked_1000	CYP1B1 SORBS2 ZBTB20 PKP4 LAMA2 CP GMPS KANSL1 STARD9 HERC1 TNS1 BOLL MPP7	7.53e-05	797	98	13	gudmap_developingGonad_P2_epididymis_1000
ToppCell	Children_(3_yrs)-Mesenchymal-pericyte_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	MARK1 LAMA2 RASL12 NKD1 CLMN STARD9 TNS1 FOXF1	1.07e-08	188	100	8	ee151792c7ac9afe820f1a281c6dab383799f358
ToppCell	nucseq-Mesenchymal-Myocytic-Myocytic_1-Pericyte\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	EPS8 MARK1 RASL12 FAT1 KCNQ4 CLMN STARD9 TNS1	1.17e-08	190	100	8	4eb92aef1ee868f4537483d19014d947b7684612
ToppCell	nucseq-Mesenchymal-Myocytic-Myocytic_1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	EPS8 MARK1 RASL12 FAT1 KCNQ4 CLMN STARD9 TNS1	1.17e-08	190	100	8	7be4341e2909101d756f14031c21e705eb45e69a
ToppCell	Fetal_29-31_weeks-Mesenchymal-myofibroblast_cell-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	FAT4 MARK1 PRAG1 HEPH FAT1 NKD1 SLITRK6 FOXF1	1.26e-08	192	100	8	72881b280a415e65f87a80ca1369cbb0b722a0c4
ToppCell	Tracheal-NucSeq\|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations	ZBTB20 ARHGEF28 INO80D KMT2C KANSL1 SSH2 HERC1 EIF4G3	1.67e-08	199	100	8	94b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCell	Parenchyma_Control_(B.)-Stromal-TX-Smooth_muscle-1\|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type	MARK1 LAMA2 RASL12 PLEKHH3 FAT1 STARD9 TNS1 FOXF1	1.74e-08	200	100	8	0c648941447c738caf62f2d71e296d6cca492c8b
ToppCell	Lung_Parenchyma-Control-Mesenchymal-Mesenchymal-Smooth_muscle-1-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	MARK1 LAMA2 RASL12 PLEKHH3 FAT1 STARD9 TNS1 FOXF1	1.74e-08	200	100	8	522a51a284d2992d519c4669e1a48c8ebcc08c80
ToppCell	Lung_Parenchyma-Control-Mesenchymal-Mesenchymal-Smooth_muscle-1\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	MARK1 LAMA2 RASL12 PLEKHH3 FAT1 STARD9 TNS1 FOXF1	1.74e-08	200	100	8	94f1fa61aa82eb9f411b2b1cb759476939ab5db7
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	ZBTB20 INO80D KMT2C KANSL1 NFKB1 MACF1 HERC1	2.29e-07	188	100	7	ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell	Mesenchymal-myofibroblast_cell\|World / Lineage, Cell type, age group and donor	FAT4 MARK1 LAMA2 HEPH FAT1 NKD1 SLITRK6	2.38e-07	189	100	7	44e37f88137bb249933eb615235b2cf2ae7f3925
ToppCell	Bronchial-NucSeq-Epithelial-Epi_airway_basal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DSC3 MARK1 SLC4A3 GDA FAT1 DMRT3 CLMN	3.48e-07	200	100	7	8827653738a931e4a4545e0c7d75be12bed40740
ToppCell	3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell-Pericytes-Pericytes_L.2.3.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	RASL12 PLEKHH3 KCNQ4 STARD9 TNS1 FOXF1	2.99e-06	177	100	6	452ec2df36c6d656a7cdadc55be545ccdb146a29
ToppCell	Fetal_29-31_weeks-Mesenchymal-airway_smooth_muscle_cell-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	RASL12 FAT1 NKD1 SLITRK6 FOXF1 SMAD9	3.40e-06	181	100	6	25915e2500430a902db37d79a749ce2990b69810
ToppCell	droplet-Kidney-nan-18m-Mesenchymal-podocyte\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CYP1B1 SORBS2 WT1 LAMA2 CP PLEKHH3	3.51e-06	182	100	6	e3248d108b51c49ca2c978636e13017e23b53860
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	EPS8 LAMA2 RASL12 SPECC1 NKD1 TNS1	3.62e-06	183	100	6	667717366cb181b8a04a347e64f0f5a4dfc6ee7f
ToppCell	3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell-Pericytes-Pericytes_L.2.3.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MARK1 LAMA2 RASL12 FAT1 STARD9 TNS1	3.98e-06	186	100	6	888e85a025bd982d36c910db0f5a3385b1ca3b28
ToppCell	droplet-Limb_Muscle-Pre-Sort-18m-Mesenchymal-smooth_muscle_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SORBS2 MARK1 RASL12 SLC4A3 NKD1 TNS1	4.63e-06	191	100	6	8e8beb8e8a3b33cac83d3f7ce915a71e3654fdab
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	EPS8 LAMA2 ARHGAP17 RASL12 SPECC1 CLMN	4.63e-06	191	100	6	7b0d42a877540dbb346a76a62403e0d5d3e07fa6
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	EPS8 LAMA2 ARHGAP17 RASL12 SPECC1 CLMN	4.63e-06	191	100	6	cd854b9c426924fdc84bf7f411f6dea447143e79
ToppCell	nucseq\|World / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ZBTB20 ANKHD1 KMT2C KANSL1 SSH2 EIF4G3	4.92e-06	193	100	6	779276e775cb2492e8dd36436295a536084a6415
ToppCell	Posterior_cortex-Neuronal\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	USP29 DISP2 ACTL6B HERC1 BSN EIF4G3	4.92e-06	193	100	6	b4989e3436e84dbec3789b46057e0f7a0ebf09d4
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_myocytic-mes_immature_ASM1_(8)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	LAMA2 PRAG1 RNF43 FAT1 NKD1 FOXF1	5.06e-06	194	100	6	fb80a0271ccb1cb3f954ebcf2c5945cb6adb6b8c
ToppCell	(3)_Chondrocytes-(30)_Chondro\|(3)_Chondrocytes / Cell class and subclass of bone marrow stroma cells in homeostatis	CACNA1E FAT4 SORBS2 DSC3 LAMA2 NFKB1	5.22e-06	195	100	6	f5597d3ed37770c6fa2b339f98a80ac7ecd4f9ff
ToppCell	Bronchial-NucSeq-Stromal-Fibroblastic-Fibro_myofibroblast\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	FAT4 DSC3 MARK1 LAMA2 SLC4A3 NKD1	5.22e-06	195	100	6	f5e91ce20a7ce528dc4c1a968c7bf096bf45c528
ToppCell	Bronchial-NucSeq-Epithelial-Epi_airway_basal-Basal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DSC3 MARK1 SLC4A3 FAT1 CLMN SLITRK6	5.53e-06	197	100	6	1e915957ea6a4550ecb9d6ee4b232aa5800faf20
ToppCell	ILEUM-non-inflamed-(8)_Fibroblast-(8)_Pericytes\|(8)_Fibroblast / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	EPS8 SORBS2 RASL12 SPECC1 CLMN TNS1	5.53e-06	197	100	6	608328608cef82adc867a449216839622253d486
ToppCell	PSB-critical-LOC-Epithelial-Basal\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CACNB4 DSC3 RYR1 PLEKHH3 SLITRK6 TNS1	5.86e-06	199	100	6	2add64c3e4cb6384ec381f34c3f1f77e13e3f27c
ToppCell	LPS_IL1RA_TNF-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	EPS8 ARHGEF28 CP RNF43 FASN FAT1	6.03e-06	200	100	6	e8db082aa4d0597500e4f16a5c0ea3e62c6c59ae
ToppCell	LPS_IL1RA\|World / Treatment groups by lineage, cell group, cell type	CYP1B1 HIVEP2 PKP4 CP SH2B2 NFKB1	6.03e-06	200	100	6	a02fa5b3c4723a6eaa3c685588666c710478dd25
ToppCell	Tracheal-NucSeq-Epithelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CACNB4 SORBS2 ARHGEF28 PKP4 CLMN MPP7	6.03e-06	200	100	6	d3af0a706baf66e3f32e67b17dcfc31e5b32ce0e
ToppCell	LPS_anti-TNF-Mesenchymal_myocytic-Pericyte-Pericyte_2\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	EPS8 LAMA2 RASL12 SPECC1 PLEKHH3 FAT1	6.03e-06	200	100	6	786f1ae53e60b5ffbf4bfd393d10b802478148b3
ToppCell	Globus_pallidus\|World / BrainAtlas - Mouse McCarroll V32	ZBTB20 ZAN SZT2 N4BP2 MROH7	9.68e-06	126	100	5	44b63f945d5bedf1a2ca1810e7e100276ea9dd89
ToppCell	Club_cells-Donor_03\|World / lung cells shred on cell class, cell subclass, sample id	PKP4 CP BTBD16 FAT1 SLITRK6	2.04e-05	147	100	5	5a824c89e4d045af465d7333275f8191fb29b041
ToppCell	TCGA-Bone_and_Soft_Tissue-Primary_Tumor-Sarcoma-Conventional_Leiomyosarcoma\|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9	RASL12 SPECC1 KCNQ4 TNS1 MPP7	2.47e-05	153	100	5	ec6fe6b8c884fa76adc7a0f9db041f7b1567a2ee
ToppCell	10x5'-bone_marrow-Lymphocytic_T_CD4-T_CD4/CD8\|bone_marrow / Manually curated celltypes from each tissue	HIVEP2 KMT2C KANSL1 MACF1 HERC1	2.71e-05	156	100	5	1545169694f686d28648a68b552c2ae606599d66
ToppCell	wk_15-18-Mesenchymal-Myofibro_&_SMC-Myofibro_2\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	PRAG1 RNF43 FAT1 NKD1 FOXF1	2.80e-05	157	100	5	b9d04ee417c0d8ea0801d10f1c54e138587009fd
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	EPS8 ARHGEF28 TMPRSS11E MPP7 SMAD9	3.45e-05	164	100	5	d847d509bb1791638032ade6755d8164586b5bd5
ToppCell	TCGA-Ovary-Primary_Tumor-Ovarian_Carcinoma-Serous_Cystadenocarcinoma-5\|TCGA-Ovary / Sample_Type by Project: Shred V9	SZT2 INO80D SETD2 KCNQ4 ANKS1A	3.65e-05	166	100	5	32d2eaf8a5d03881bf74d680825af2d5110b082d
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Outer_Medullary_Collecting_Duct_Intercalated_Cell_Type_A\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	EPS8 ARHGEF28 TMPRSS11E MPP7 SMAD9	3.65e-05	166	100	5	6fe8db8d45177a78605681f22e04fa8d0594f2df
ToppCell	E18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_prolif\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SH2B2 STARD9 MACF1 SLITRK6 TNS1	3.98e-05	169	100	5	16c52a0f6d96ecc1832922fce9b39691849f0d73
ToppCell	facs-Heart-RA-18m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MARK1 RASL12 CAPRIN2 FOXF1 SMAD9	4.21e-05	171	100	5	b54d9d6b03c9c6f28a71cf2ed2bfa9a335bba949
ToppCell	facs-Heart-RA-18m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MARK1 RASL12 CAPRIN2 FOXF1 SMAD9	4.21e-05	171	100	5	9d825a2e799421af4f2cf4f4dc8e239b5d00476d
ToppCell	Control-Fibroblasts-Pericytes\|Control / group, cell type (main and fine annotations)	EPS8 MARK1 LAMA2 KCNQ4 TNS1	4.21e-05	171	100	5	080003f698f867935c2bfc55d241d3650f45a0ab
ToppCell	3'_v3-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8\|lymph-node_spleen / Manually curated celltypes from each tissue	KANSL1 NFKB1 DUSP16 MACF1 HERC1	4.21e-05	171	100	5	2e9a20f8980b78325c52065a9c14ab3656267c05
ToppCell	Children_(3_yrs)-Mesenchymal-myofibroblast_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	FAT4 MARK1 LAMA2 NKD1 SLITRK6	4.45e-05	173	100	5	1f16d47f5548e257e4b17f8070c5619780a9c5fd
ToppCell	Children_(3_yrs)-Mesenchymal-vascular_smooth_muscle_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	MARK1 NKD1 KCNQ4 CLMN TNS1	4.45e-05	173	100	5	5416b092321c7d9b63f0418c60f2402a138355bf
ToppCell	Tuft-tuft-4\|World / Class top	CACNB4 AMT NKD1 PACS2 USPL1	4.57e-05	174	100	5	d6f306ebf66061bf9e9742000bfedce12d277452
ToppCell	3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts-Myofibroblasts_L.2.3.2.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FAT4 LAMA2 NKD1 MACF1 TNS1	4.70e-05	175	100	5	1799a7be623dc3bf53ba580a7c47d2619969d708
ToppCell	facs-Heart-RV-18m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SORBS2 DSC3 MARK1 RASL12 FOXF1	4.70e-05	175	100	5	d8e385320f554d974538b7cdc4f8e4767f1455f2
ToppCell	COVID-19-Heart-VSMC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	EPS8 MARK1 RASL12 SPECC1 CLMN	4.70e-05	175	100	5	1125f0d3a5b2388fa77a820dea0288e824d84a82
ToppCell	facs-Heart-RV-18m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SORBS2 DSC3 MARK1 RASL12 FOXF1	4.70e-05	175	100	5	cf15465855602ba135752c18755e3e058dbd42ec
ToppCell	Children_(3_yrs)-Mesenchymal-airway_smooth_muscle_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	FAT4 MARK1 LAMA2 NKD1 SLITRK6	4.96e-05	177	100	5	b59967219f7d874805768e247c0eb2bc4d4420c8
ToppCell	3'-Adult-Appendix-Epithelial-epithelial_progenitor_cell-Stem_cells\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ZNF823 CACNB4 DPH7 ZNF302 PACS2	4.96e-05	177	100	5	34458f1eb7f3b1fd0cb9904529c01a9ca2f15500
ToppCell	droplet-Liver-hepatocytes-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAT4 INO80D NKD1 ALMS1 DISP2	4.96e-05	177	100	5	8ef41ee5d63737b810ad7371b0437625e7e1badf
ToppCell	Children_(3_yrs)-Mesenchymal-pericyte_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	MARK1 RASL12 CLMN STARD9 TNS1	5.09e-05	178	100	5	185b44700f06ec58b3c09c80520502166c965fd6
ToppCell	droplet-Kidney-nan-18m-Epithelial-Epcam____podocyte\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNC MARK1 WT1 CP FOXF1	5.09e-05	178	100	5	445fb243d738a34794d66f34b92dde1f3ea6738e
ToppCell	10x5'v1-week_12-13-Mesenchymal_osteo-stroma-osteochondral_precursor\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	NBPF6 RASL12 HEPH FAT1 FOXF1	5.23e-05	179	100	5	98c0c5c8034ae8a4b3ceea7fd1d0386ee5f89d09
ToppCell	Children_(3_yrs)-Mesenchymal-myofibroblast_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	FAT4 MARK1 LAMA2 NKD1 SLITRK6	5.37e-05	180	100	5	01f2e5d96016823482f89ba503d007d4bd88eeac
ToppCell	10x5'-Liver-Lymphocytic_T_CD4-T_CD4/CD8\|Liver / Manually curated celltypes from each tissue	ZBTB20 KANSL1 NFKB1 MACF1 HERC1	5.51e-05	181	100	5	f2315414e714ac86211546a935660c4be6e85f1b
ToppCell	Globus_pallidus-Neuronal-Inhibitory\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	GMPS IQSEC1 DISP2 EIF4G3 SMAD9	5.66e-05	182	100	5	04ccfa951eaa31fed6d140edb6c702d49363c5fa
ToppCell	RA-13._Vascular_Smooth_Muscle\|RA / Chamber and Cluster_Paper	ARHGEF28 SPECC1 NKD1 CLMN MPP7	5.80e-05	183	100	5	818fd886e0188091310825f9145fa53328f2c979
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	EPS8 CACNB4 SORBS2 RNF43 MPP7	5.80e-05	183	100	5	6847c1252d6bb105524f812658112517fd351eab
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-myocytic-myofibroblast_(RSPO2+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FLNC SORBS2 NKD1 TNS1 FOXF1	5.80e-05	183	100	5	61a73de857f4ae02dcba3af348f436f602b28ff2
ToppCell	Adult-Mesenchymal-pericyte_cell-D122\|Adult / Lineage, Cell type, age group and donor	MARK1 RASL12 KCNQ4 CLMN TNS1	5.80e-05	183	100	5	fc31a43a637423cb3bb9aa184a3a889a0b9aaea6
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	EPS8 LAMA2 RASL12 FAT1 KCNQ4	5.96e-05	184	100	5	689a8af81a79a4bb3123cfa01958c953eab5de98
ToppCell	LPS_only-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	EPS8 LAMA2 FAT1 KCNQ4 STARD9	5.96e-05	184	100	5	327ff3ac8d2fecdd5d242bdc34f0dfdb1c59a68b
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal-Mesenchymal-Mes-Pericyte\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	EPS8 RASL12 NKD1 CLMN TNS1	6.11e-05	185	100	5	0e26a71fea526ebfe3b2d1c8d0d6d9b70282bbe9
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	EPS8 MARK1 RASL12 SPECC1 CLMN	6.11e-05	185	100	5	51dfe6ac7df8b330343b37e3bee71e5c65267189
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal-Mesenchymal-Mes-Pericyte-Peri_L1-6_MUSTN1\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	EPS8 RASL12 NKD1 CLMN TNS1	6.11e-05	185	100	5	b3320b794b22e654a33f28b575c9f00023baf5f0
ToppCell	droplet-Heart-4Chambers-21m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SORBS2 MARK1 RASL12 FAT1 NKD1	6.11e-05	185	100	5	30df02fbe2828e3c4f3e5c4cda855e74fb31be39
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	EPS8 MARK1 RASL12 SPECC1 CLMN	6.11e-05	185	100	5	a8c02cec3c414f3a0da9f2d6d28ce563b0030705
ToppCell	LPS-IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SORBS2 ARHGEF28 CP RNF43 MPP7	6.27e-05	186	100	5	4e94158db52df41d71e67b02b9895a358eebee0f
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	EPS8 CACNB4 ARHGEF28 CP RNF43	6.27e-05	186	100	5	e83718fabb057100835d3357df407f283d23fe16
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1E HIVEP2 SLC4A3 GDA BSN	6.27e-05	186	100	5	7278a1a1bf9bb27aeb03852134defb31b62f30d6
ToppCell	Adult-Mesenchymal-pericyte_cell\|Adult / Lineage, Cell type, age group and donor	MARK1 RASL12 KCNQ4 STARD9 TNS1	6.43e-05	187	100	5	62759efb660179402fb574ce5701c89a2e17bcfe
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	EPS8 RASL12 SPECC1 NKD1 CLMN	6.43e-05	187	100	5	ec4b694487cc446999c7b27b119950a4f252c4b3
ToppCell	droplet-Heart-4Chambers-21m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SORBS2 MARK1 RASL12 FAT1 NKD1	6.43e-05	187	100	5	8ff9f771d10c372d771c92dfa9006aa81aec4681
ToppCell	human_hepatoblastoma-Tumor_cells-T2\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	SORBS2 ZBTB20 ARHGEF28 RNF43 CLMN	6.43e-05	187	100	5	f3e37c18ac6471c7992609bbddfa4975571c815c
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	EPS8 RASL12 SPECC1 NKD1 CLMN	6.43e-05	187	100	5	530e4e6d91b5c0d9aa4543caa2b734a1674c5788
ToppCell	Fetal_29-31_weeks-Mesenchymal-myofibroblast_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	MARK1 HEPH FAT1 NKD1 SLITRK6	6.43e-05	187	100	5	c104fbfef2d0bef64077ac721edf2379fd59d547
ToppCell	Fetal_29-31_weeks-Mesenchymal-pericyte_cell-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	EPS8 MARK1 RASL12 CLMN STARD9	6.59e-05	188	100	5	ccddc08121caff958a2b6f9e278a018858af6b4d
ToppCell	LPS-IL1RA-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	EPS8 CACNB4 ARHGEF28 CP RNF43	6.59e-05	188	100	5	4bdf8d49af0e9da349b16e3f012e1b0eec04cc4f
ToppCell	Fetal_29-31_weeks-Mesenchymal-airway_smooth_muscle_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	FLNC MARK1 FAT1 NKD1 FOXF1	6.59e-05	188	100	5	4d1e5f85342ae550086609d7680e32730b78b5d2
ToppCell	Substantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	CACNA1E USP29 OGDH DISP2 BSN	6.59e-05	188	100	5	b73e8a40393c3f656e2fcfe395a761b1f985c254
ToppCell	Pericytes-IPF_03\|World / lung cells shred on cell class, cell subclass, sample id	FLNC MARK1 RASL12 NKD1 KCNQ4	6.59e-05	188	100	5	14c1c88a944c66f2eaac1ce7526815dcce1f5147
ToppCell	LA-13._Vascular_Smooth_Muscle\|World / Chamber and Cluster_Paper	ARHGEF28 SPECC1 NKD1 MACF1 MPP7	6.76e-05	189	100	5	6b3e88751b95fc2173f2c3d5061ed632d0c5f01c
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	EPS8 RASL12 SPECC1 NKD1 STARD9	6.76e-05	189	100	5	fac5c291a9a87418bb0878c3d624829bdbf1f428
ToppCell	droplet-Kidney-KIDNEY-30m-Epithelial-Epcam____podocyte\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CYP1B1 FLNC WT1 CP FAT1	6.76e-05	189	100	5	319e42f6e2322208de78bc666fb2c074707eb4da
ToppCell	RV-15._Ventricular_Cardiomyocyte_III\|RV / Chamber and Cluster_Paper	FLNC SORBS2 LAMA2 FAT1 XIRP2	6.93e-05	190	100	5	93c3188dfeb0b2f9889f8ae9b9c1f2f34129c99b
ToppCell	Mesenchymal-airway_smooth_muscle_cell\|World / Lineage, Cell type, age group and donor	FLNC MARK1 FAT1 NKD1 FOXF1	6.93e-05	190	100	5	645e56b02edc3702c7db917b8ecd5eed0decaf71
ToppCell	droplet-Kidney-KIDNEY-30m-Epithelial-podocyte\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CYP1B1 FLNC WT1 CP FAT1	6.93e-05	190	100	5	050d6e0546954675b6adbfecb67854b1e09739d1
ToppCell	droplet-Kidney-nan-21m-Epithelial-kidney_mesangial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SORBS2 MARK1 RASL12 PLEKHH3 KCNQ4	6.93e-05	190	100	5	1803b1e7c36285f9eaabc3c6e9a9752c5908db3d
ToppCell	Mesenchymal_cells-Smooth_muscle\|World / Lineage and Cell class	SORBS2 MARK1 RASL12 NKD1 KCNQ4	6.93e-05	190	100	5	5aa62a363a25f4a110136263b21289a11e8c1e6d
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2\|Children_(3_yrs) / Lineage, Cell type, age group and donor	EPS8 CACNB4 SORBS2 FASN MPP7	7.11e-05	191	100	5	a0332a4ef629510fb313ec119195c44a3f704a80
ToppCell	facs-Lung-24m-Mesenchymal-fibroblast\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	LAMA2 CP RASL12 MACF1 TNS1	7.11e-05	191	100	5	094c9d3270fc1e487ccf10fb4936af5f081f6009
ToppCell	3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	LAMA2 RASL12 STARD9 TNS1 FOXF1	7.11e-05	191	100	5	1626b23a57429f835fddc052e3c57f63a4e5b8bb
ToppCell	3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell-Pericytes\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	LAMA2 RASL12 STARD9 TNS1 FOXF1	7.11e-05	191	100	5	716dfa7fccbd62b5f574792e68a26dc6c45511dc
ToppCell	10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell-Pericyte-A\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	EPS8 SORBS2 LAMA2 RASL12 CLMN	7.28e-05	192	100	5	fee99ca7e658963acf968aa724ef8c96cfc00a5d
ToppCell	10x5'-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8\|lymph-node_spleen / Manually curated celltypes from each tissue	KMT2C KANSL1 NFKB1 MACF1 HERC1	7.28e-05	192	100	5	47646d7e4990be85072987f92bf18d52f8da752e
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_myocytic-mes_immature_ASM1_(8)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	PKP4 PRAG1 FAT1 NKD1 FOXF1	7.28e-05	192	100	5	4c9d748f209cc1e13d28c8c7f5180ab8522e0fbf
Drug	methylparaben	CACNA1E GPR15 ESR2 CES2 BOLL	2.17e-08	20	100	5	CID000007456
Disease	Intellectual Disability	CACNA1E HIVEP2 PEX6 KMT2C SETD2 FASN KANSL1 IQSEC1 PACS2 MACF1 ACTL6B	3.25e-07	447	99	11	C3714756
Disease	lung adenocarcinoma (is_implicated_in)	RNF43 KMT2C SETD2 IQSEC1	2.25e-05	49	99	4	DOID:3910 (is_implicated_in)
Disease	Colorectal Neoplasms	CYP1B1 FLNC ESR2 RNF43 FAT1 BOLL SMAD9	4.25e-05	277	99	7	C0009404
Disease	Global developmental delay	CACNA1E SZT2 IQSEC1 PACS2 ACTL6B	8.79e-05	133	99	5	C0557874
Disease	ovarian neoplasm	CYP1B1 RNF43 FASN KANSL1 MAPK1	9.10e-05	134	99	5	C0919267
Disease	Malignant neoplasm of ovary	CYP1B1 RNF43 FASN KANSL1 MAPK1	1.01e-04	137	99	5	C1140680
Disease	smoking cessation	CACNA1E ZBTB20 OGDH ALMS1 CCDC181 BSN ANKS1A	1.15e-04	325	99	7	EFO_0004319
Disease	glucagon measurement, glucose tolerance test	MACF1 HERC1	1.66e-04	6	99	2	EFO_0004307, EFO_0008463
Disease	primary pulmonary hypertension (is_implicated_in)	RYR1 SMAD9	1.66e-04	6	99	2	DOID:14557 (is_implicated_in)
Disease	malignant mesothelioma (is_implicated_in)	WT1 SETD2	2.31e-04	7	99	2	DOID:1790 (is_implicated_in)
Disease	Malignant neoplasm of breast	CYP1B1 DSC3 ESR2 WT1 LAMA2 ZNF668 SETD2 FASN N4BP2 MROH7 MACF1 TNS1	2.55e-04	1074	99	12	C0006142
Disease	Squamous cell carcinoma of esophagus	FAT4 KMT2C FASN FAT1	3.00e-04	95	99	4	C0279626
Disease	retinal vasculature measurement	SORBS2 LAMA2 MUC12 PRAG1 XIRP2 IQSEC1 ACTL6B TNS1	3.57e-04	517	99	8	EFO_0010554
Disease	Adenoid Cystic Carcinoma	KMT2C SETD2 FAT1 KANSL1	3.65e-04	100	99	4	C0010606
Disease	Liver Diseases, Parasitic	RNF43 KMT2C	3.95e-04	9	99	2	C0023897
Disease	Tendinopathy	CACNA1E MPP7	3.95e-04	9	99	2	EFO_1001434
Disease	Hereditary Diffuse Gastric Cancer	FAT4 ZBTB20 MARK1 RNF43 KMT2C MAPK1	4.71e-04	293	99	6	C1708349
Disease	pancreatic adenocarcinoma (is_marker_for)	NFKB1 MAPK1	4.93e-04	10	99	2	DOID:4074 (is_marker_for)
Disease	Stomach Neoplasms	FAT4 ZBTB20 MARK1 RNF43 KMT2C MAPK1	5.06e-04	297	99	6	C0038356
Disease	Malignant neoplasm of stomach	FAT4 ZBTB20 MARK1 RNF43 KMT2C MAPK1	5.33e-04	300	99	6	C0024623
Disease	Cardiomyopathy, Dilated	SGCB FASN ALMS1	5.68e-04	48	99	3	C0007193
Disease	hematocrit	HIVEP2 ZBTB20 ZAN ESR2 WT1 PEX6 RNF43 FAT1 ACTL6B SSH2 BSN	5.84e-04	1011	99	11	EFO_0004348
Disease	46,XY partial gonadal dysgenesis	WT1 DMRT3	6.01e-04	11	99	2	C4510744
Disease	Carcinoma, Granular Cell	FAT4 ESR2 KMT2C NFKB1	6.40e-04	116	99	4	C0205644
Disease	Adenocarcinoma, Tubular	FAT4 ESR2 KMT2C NFKB1	6.40e-04	116	99	4	C0205645
Disease	Adenocarcinoma, Oxyphilic	FAT4 ESR2 KMT2C NFKB1	6.40e-04	116	99	4	C0205642
Disease	Carcinoma, Cribriform	FAT4 ESR2 KMT2C NFKB1	6.40e-04	116	99	4	C0205643
Disease	Adenocarcinoma, Basal Cell	FAT4 ESR2 KMT2C NFKB1	6.40e-04	116	99	4	C0205641
Disease	Adenocarcinoma	FAT4 ESR2 KMT2C NFKB1	6.40e-04	116	99	4	C0001418
Disease	Congenital muscular dystrophy	LAMA2 RYR1	7.20e-04	12	99	2	cv:C0699743
Disease	colorectal cancer (is_implicated_in)	ESR2 RNF43 SETD2 FAT1	7.50e-04	121	99	4	DOID:9256 (is_implicated_in)
Disease	juvenile polyposis syndrome (implicated_via_orthology)	HIVEP2 SMAD9	8.48e-04	13	99	2	DOID:0050787 (implicated_via_orthology)
Disease	superior parietal cortex volume measurement	BTBD16 MAPK1	1.14e-03	15	99	2	EFO_0010330
Disease	Tremor, Rubral	CACNB4 CP	1.30e-03	16	99	2	C0750940
Disease	Ataxia, Appendicular	CACNB4 CP	1.30e-03	16	99	2	C0750937
Disease	Ataxia, Motor	CACNB4 CP	1.30e-03	16	99	2	C0278161
Disease	Ataxia, Sensory	CACNB4 CP	1.30e-03	16	99	2	C0240991
Disease	Abnormal coordination	CACNB4 CP	1.30e-03	16	99	2	C0520966
Disease	Ataxia, Truncal	CACNB4 CP	1.30e-03	16	99	2	C0427190
Disease	IGF-1 measurement	SORBS2 MARK1 ESR2 TMPRSS11E OGDH STARD9 HPS5	1.30e-03	488	99	7	EFO_0004627
Disease	stomach cancer (is_marker_for)	RNF43 GDA SETD2 NFKB1	1.36e-03	142	99	4	DOID:10534 (is_marker_for)
Disease	myocardial infarction (implicated_via_orthology)	CYP1B1 RYR1 MAPK1	1.44e-03	66	99	3	DOID:5844 (implicated_via_orthology)
Disease	muscular dystrophy (is_implicated_in)	SGCB LAMA2	1.47e-03	17	99	2	DOID:9884 (is_implicated_in)
Disease	1-Methylhistidine measurement	SORBS2 ALMS1	1.47e-03	17	99	2	EFO_0021543
Disease	neurodegenerative disease (implicated_via_orthology)	FAT4 MARK1 OGDH NFKB1	1.47e-03	145	99	4	DOID:1289 (implicated_via_orthology)
Disease	Febrile seizure (within the age range of 3 months to 6 years)	HERC1 BSN	1.65e-03	18	99	2	HP_0002373
Disease	Congenital hernia of foramen of Morgagni	WT1 FOXF1	1.84e-03	19	99	2	C0265699
Disease	blood metabolite measurement	GMPS ALMS1	1.84e-03	19	99	2	EFO_0005664
Disease	Congenital hernia of foramen of Bochdalek	WT1 FOXF1	1.84e-03	19	99	2	C0265700
Disease	colorectal cancer, inflammatory bowel disease	ALMS1 KCNQ4	1.84e-03	19	99	2	EFO_0003767, MONDO_0005575
Disease	major depressive disorder	HIVEP2 ESR2 BSN MUCL3	1.87e-03	155	99	4	MONDO_0002009
Disease	unipolar depression, bipolar disorder	CACNA1E FAT4 ESR2 STARD9	1.92e-03	156	99	4	EFO_0003761, MONDO_0004985
Disease	intellectual disability (implicated_via_orthology)	HIVEP2 RBL1 KANSL1	2.08e-03	75	99	3	DOID:1059 (implicated_via_orthology)
Disease	Congenital diaphragmatic hernia	WT1 FOXF1	2.24e-03	21	99	2	C0235833
Disease	Colorectal Carcinoma	CYP1B1 FLNC ESR2 RNF43 KMT2C FAT1 BOLL SMAD9	2.53e-03	702	99	8	C0009402
Disease	primary open angle glaucoma (is_implicated_in)	CYP1B1 ESR2	2.69e-03	23	99	2	DOID:1070 (is_implicated_in)
Disease	phosphatidylcholine measurement	ESR2 TMPRSS11E PEX6 IQSEC1 MACF1	2.73e-03	284	99	5	EFO_0010226
Disease	Intrahepatic Cholangiocarcinoma	RNF43 KMT2C	2.93e-03	24	99	2	C0345905
Disease	Extrahepatic Cholangiocarcinoma	RNF43 KMT2C	2.93e-03	24	99	2	C3805278
Disease	Cancer of Head	FAT1 MAPK1	2.93e-03	24	99	2	C0751177
Disease	stomach carcinoma (is_marker_for)	RNF43 KMT2C	2.93e-03	24	99	2	DOID:5517 (is_marker_for)
Disease	Head Neoplasms	FAT1 MAPK1	2.93e-03	24	99	2	C0018675
Disease	Upper Aerodigestive Tract Neoplasms	FAT1 MAPK1	2.93e-03	24	99	2	C0887900
Disease	Ataxia	CACNB4 CP	3.18e-03	25	99	2	C0004134
Disease	Neck Neoplasms	FAT1 MAPK1	3.18e-03	25	99	2	C0027533
Disease	Cancer of Neck	FAT1 MAPK1	3.18e-03	25	99	2	C0746787

Protein segments in the cluster

Peptide	Gene	Start	Entry
EQGTLYSPEQTSLHE	PKP4	121	Q99569
YSPEQTSLHESEGSL	PKP4	126	Q99569
IIYSPESTDSGNTHQ	nan	446	A8MVM7
PSHTSTDYHELGRSI	SLC4A3	561	P48751
HGIYLPSDTQEHAGS	CACNA1E	1981	Q15878
TDLESPSAVYEHNHV	BTBD16	426	Q32M84
ATHTTAIPVHDGYVL	ACTL6B	171	O94805
HNGVAYFHTPEVTSV	BOLL	141	Q8N9W6
DIRETHSHVPYTSVF	GPR15	21	P49685
HITVTEENYHTPEFS	FAT4	3076	Q6V0I7
LQTVPSGTYSHGENH	ALMS1	2181	Q8TCU4
YLEHSPNSEGAASHT	SPECC1	256	Q5M775
VDSTGYTPLHHAALN	ANKS1A	76	Q92625
GSSLYQVSTHEQPDS	FLG	466	P20930
SSSQHSRDHYPLVEE	CACNB4	476	O00305
ETVYDPSLPASHHSS	DISP2	1346	A7MBM2
YGISLHSSTHEPNST	MROH7	306	Q68CQ1
HTIYEVVDSSVNHSP	NKD1	161	Q969G9
NEVYLTPSVHHDVSD	NBPF4	436	Q96M43
TYSSEETVDHQPVHL	RASL12	56	Q9NYN1
SHNHSSEYSDPLELV	LILRA2	101	Q8N149
VIHQDATYPTTQSHS	ARHGEF28	1586	Q8N1W1
PYSIHAHGVQTESST	CP	831	P00450
DADGPSNSHIHYSII	FAT1	3361	Q14517
PDHDHTGFLTEYVAT	MAPK1	176	P28482
ITHGHSYPGSTQSLI	KMT2C	3576	Q8NEZ4
EHGSIYIPSSYVDSH	ESR2	26	Q92731
SSLSPDHYEHTSVGA	IQSEC1	51	Q6DN90
HTHVASLLGYSSPSD	HERC1	896	Q15751
STSGHVDHTLQQYSP	HPS5	756	Q9UPZ3
SDYHSPVDHEDISVS	KCNQ4	666	P56696
HSPTTANYGSQTEDL	BSN	1421	Q9UPA5
LHIEIVSSPHYSTNG	PEX6	321	Q13608
LSIYTPAHSHEGSNL	CES2	126	O00748
NGDGTHTVHYTPATD	FLNC	1496	Q14315
SDTQHYGVTVPHTTR	MPP7	391	Q5T2T1
PHRSLDVEHTTLYSN	KANSL1	211	Q7Z3B3
TAQDEVYLHPSEEHT	LAMA2	636	P24043
PYFEGLSHSSSQTEI	PACS2	321	Q86VP3
GHPHIITLIDSYESS	PHKG2	86	P15735
HTLETEYIHDETGGS	MACF1	2181	Q9UPN3
LSDLPSYTTHGTVHV	OGDH	426	Q02218
IHAVTHSSTGEPLAY	CCDC181	276	Q5TID7
HSFYNGTTTLPISDE	GMPS	301	P49915
SVHPSTGVITTVSHY	DSC3	296	Q14574
QSSPHREHILATGSY	DPH7	246	Q9BTV6
GHIFEHTLSSYPISS	DMRT3	311	Q9NQL9
SPLHRSGSVEDNYHT	DUSP16	501	Q9BY84
AAAQTTHTTYPEGLE	CENPJ	1211	Q9HC77
THTTYPEGLEVLHFS	CENPJ	1216	Q9HC77
VHSQETAANYHPDGT	CAPRIN2	816	Q6IMN6
SITSATDEQPHIGNY	MARK1	46	Q9P0L2
DSEHVPSPYSDHITS	INO80D	831	Q53TQ3
DHITSPHTTSYSGDN	INO80D	841	Q53TQ3
PGLVDTHIHASQYSF	GDA	76	Q9Y2T3
HATTANTSVLGYHIP	CYP1B1	401	Q16678
STEHSSVSEYHPADG	EPS8	476	Q12929
SLPVQYRDSHTDSHL	AMT	56	P48728
TSSESPDHYLVDHTL	FASN	866	P49327
HPHYEVSRVDGTVDT	RYR1	1251	P21817
HSPVVYGTVESAHLA	EIF4G3	191	O43432
ITSEATGNESHPYLN	MUCL3	411	Q3MIW9
SGSLSTHSLEQPYLH	FOXF1	301	Q12946
DSESPPAQLVSTYHH	SZT2	3401	Q5T011
GETEPIHSVSYGHVA	PLEKHH3	696	Q7Z736
THHTTERPSASLYEQ	SLITRK6	666	Q9H5Y7
VPEHVETRTLYSHSQ	FER1L5	1671	A0AVI2
NEVYLTPSVHHDVSD	NBPF6	436	Q5VWK0
HYTQSTDEQPGSHID	RBL1	441	P28749
STSHLDEFYSDPHAV	ARHGAP17	306	Q68EM7
SRPYSVHAHGVLEST	HEPH	831	Q9BQS7
VVPTGETQVSSHVHY	RNF43	536	Q68DV7
HSVDTSPGYHESDSK	TICAM2	21	Q86XR7
PYNSVLTTHSTTEHT	TUBAL3	191	A6NHL2
PGNITEESHDSVYSS	STARD9	1836	Q9P2P6
STDYETHEFHLPSGV	SGCB	181	Q16585
QHGTSLDSTDTYPQH	SORBS2	26	O94875
YHATEASETQSGQPV	SMAD9	231	O15198
VYPSVDIDAHTESNH	ANKHD1	1041	Q8IWZ3
NGERTYTVNHETSHP	CLMN	331	Q96JQ2
ADVYHDLIHSPASET	C12orf4	126	Q9NQ89
PTLDHTLNETDHSYE	XIRP2	2541	A4UGR9
HPSHDYDISLAELSS	TMPRSS11E	271	Q9UL52
SVRNHETTHTGEKPY	ZNF823	346	P16415
TVPGVSLYSSQTHEE	USPL1	956	Q5W0Q7
INETHTNIPELSSHY	TLR3	661	O15455
SYQSHERTHSGEKPF	ZNF668	266	Q96K58
NEHTYVHSSATIPLD	AARS1	21	P49588
ATLHTVHPDSVSSSY	SEC16A	511	O15027
IIEYTHIVTSPNHTG	SSH2	1011	Q76I76
HLENGPSVSVDYNTS	TNS1	316	Q9HBL0
NHSTGYESDNHTTPI	WT1	266	P19544
HIGSSPNSGHYISDV	USP29	831	Q9HBJ7
PYGHSRSSEDVSTHA	SH2B2	111	O14492
VHDESHFSYSLSPGN	PRAG1	856	Q86YV5
QGHTSVLHSYPESVG	RALGAPB	16	Q86X10
HAPEIVSTVHEDYSG	SETD2	1026	Q9BYW2
DTESGYLQSHPQHSV	ZBTB20	226	Q9HC78
SFQTEIHSSYPLEHV	HIVEP2	1246	P31629
YSPSSLQTHEKTHTG	ZNF433	376	Q8N7K0
FQSHETTHSEEEPYE	ZNF44	511	P15621
ESHYVSFDGSNHSIP	ZAN	1936	Q9Y493
LTNHQSTHTGEKPYE	ZNF302	351	Q9NR11
GHVEESTAYHRSPGS	MUC12	496	Q9UKN1
VTETGDNIHSPSHFS	N4BP2	1271	Q86UW6
HVDSTTYDGTTPLHI	NFKB1	711	P19838