Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionphosphatidylinositol 3-kinase binding

IRS4 ESR1 IRS1 IRS2

1.72e-0543724GO:0043548
GeneOntologyMolecularFunctioninsulin receptor binding

IRS4 IRS1 IRS2

1.70e-0430723GO:0005158
GeneOntologyMolecularFunctionphosphatidylinositol 3-kinase activator activity

IRS1 IRS2

4.54e-049722GO:0141038
GeneOntologyBiologicalProcessregulation of mesenchymal cell proliferation

CTNNBIP1 KDR IRS1 IRS2

1.93e-0545734GO:0010464
DomainPTBI

IRS4 IRS1 IRS2

8.87e-0611723SM00310
DomainIRS_PTB

IRS4 IRS1 IRS2

1.18e-0512723PS51064
DomainIRS_PTB

IRS4 IRS1 IRS2

1.94e-0514723IPR002404
DomainIRS

IRS4 IRS1 IRS2

1.94e-0514723PF02174
DomainIRF-3

IRF8 IRF3

3.04e-047722PF10401
DomainInterferon_reg_factor-3

IRF8 IRF3

3.04e-047722IPR019471
DomainIRF-3

IRF8 IRF3

3.04e-047722SM01243
DomainIRF

IRF8 IRF3

5.18e-049722SM00348
DomainInterferon_reg_fact_DNA-bd_dom

IRF8 IRF3

5.18e-049722IPR001346
DomainIRF

IRF8 IRF3

5.18e-049722PF00605
DomainIRF_1

IRF8 IRF3

5.18e-049722PS00601
DomainInterferon_reg_fac_CS

IRF8 IRF3

5.18e-049722IPR019817
DomainIRF_2

IRF8 IRF3

5.18e-049722PS51507
DomainSMAD_FHA_domain

STARD9 IRF8 IRF3

1.06e-0352723IPR008984
DomainSMAD_dom-like

IRF8 IRF3

1.70e-0316722IPR017855
Domain-

IRF8 IRF3

1.70e-03167222.60.200.10
DomainTyr_Pase_AS

DUSP18 EPM2A PTPN14

2.82e-0373723IPR016130
DomainProtein_kinase_ATP_BS

STK32A AURKC TNNI3K NUAK1 STK32B KDR

3.40e-03379726IPR017441
DomainFERM_CS

PTPN14 EPB41L4B

3.83e-0324722IPR019747
DomainTYR_PHOSPHATASE_1

DUSP18 EPM2A PTPN14

4.47e-0386723PS00383
DomainFERM_C

PTPN14 EPB41L4B

4.49e-0326722PF09380
DomainTYR_PHOSPHATASE_2

DUSP18 EPM2A PTPN14

4.62e-0387723PS50056
DomainTYR_PHOSPHATASE_dom

DUSP18 EPM2A PTPN14

4.62e-0387723IPR000387
DomainFERM_C

PTPN14 EPB41L4B

4.83e-0327722SM01196
DomainFERM_PH-like_C

PTPN14 EPB41L4B

4.83e-0327722IPR018980
Domain-

DUSP18 EPM2A PTPN14

5.40e-03927233.90.190.10
DomainDUSP

DUSP18 EPM2A

6.34e-0331722IPR024950
DomainProt-tyrosine_phosphatase-like

DUSP18 EPM2A PTPN14

6.61e-0399723IPR029021
DomainFERM_N

PTPN14 EPB41L4B

7.16e-0333722PF09379
DomainFERM_N

PTPN14 EPB41L4B

7.16e-0333722IPR018979
DomainTYR_PHOSPHATASE_DUAL

DUSP18 EPM2A

7.59e-0334722PS50054
PathwayWP_LEPTININSULIN_SIGNALING_OVERLAP

IRS4 IRS1 IRS2

2.44e-0517483M39517
PathwayREACTOME_SIGNALING_BY_TYPE_1_INSULIN_LIKE_GROWTH_FACTOR_1_RECEPTOR_IGF1R

IRS4 CILP IRS1 IRS2

3.30e-0554484M27168
PathwayWP_LEPTININSULIN_SIGNALING_OVERLAP

IRS4 IRS1 IRS2

4.06e-0520483MM15867
PathwayKEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY

ACSL4 IRS4 IRS1 IRS2

7.75e-0567484M10462
PathwayREACTOME_IRS_ACTIVATION

IRS1 IRS2

1.13e-045482M27707
PathwayREACTOME_SOS_MEDIATED_SIGNALLING

IRS1 IRS2

2.36e-047482M19489
PathwayKEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION

IRS4 IRS1 IRS2

3.87e-0442483M16473
PathwayREACTOME_PI3K_AKT_ACTIVATION

IRS1 IRS2

4.03e-049482M714
PathwayREACTOME_SIGNAL_ATTENUATION

IRS1 IRS2

5.02e-0410482M14236
PathwayKEGG_TYPE_II_DIABETES_MELLITUS

IRS4 IRS1 IRS2

5.41e-0447483M19708
PathwayREACTOME_SIGNALING_BY_TYPE_1_INSULIN_LIKE_GROWTH_FACTOR_1_RECEPTOR_IGF1R

IRS4 CILP IRS2

5.41e-0447483MM14885
PathwayREACTOME_SIGNALING_BY_LEPTIN

IRS1 IRS2

6.12e-0411482M27195
PathwaySIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES

IRS4 IRS1 IRS2

6.88e-0451483M7955
PathwayWP_INTERFERON_TYPE_I_SIGNALING

IRS1 IRS2 STAT4

8.14e-0454483M39435
Pubmed

Selective alterations in insulin receptor substrates-1, -2 and -4 in theca but not granulosa cells from polycystic ovaries.

IRS4 IRS1 IRS2

9.25e-09374315155816
Pubmed

Estrogen receptor-alpha regulates the degradation of insulin receptor substrates 1 and 2 in breast cancer cells.

ESR1 IRS1 IRS2

9.25e-09374312821935
Pubmed

53BP2S, interacting with insulin receptor substrates, modulates insulin signaling.

IRS4 IRS1 IRS2

3.69e-08474317965023
Pubmed

Protein kinase C-zeta phosphorylates insulin receptor substrate-1, -3, and -4 but not -2: isoform specific determinants of specificity in insulin signaling.

IRS4 IRS1 IRS2

9.22e-08574318202124
Pubmed

Differential roles of insulin receptor substrates in brown adipocyte differentiation.

IRS4 IRS1 IRS2

3.22e-07774314966273
Pubmed

Crosstalk between the p190-B RhoGAP and IGF signaling pathways is required for embryonic mammary bud development.

ESR1 IRS1 IRS2

7.70e-07974317662267
Pubmed

IRS2 signalling is required for the development of a subset of sensory spinal neurons.

IRS4 IRS1 IRS2

7.70e-07974322288475
Pubmed

Insulin-like growth factor axis gene polymorphisms and clinical outcomes in pancreatic cancer.

IRS4 IRS1 IRS2

1.10e-061074320416304
Pubmed

Insulin-like growth factor axis gene polymorphisms modify risk of pancreatic cancer.

IRS4 IRS1 IRS2

1.10e-061074321852217
Pubmed

Insulin receptor substrate 4 associates with the protein IRAS.

IRS4 IRS1 IRS2

2.01e-061274311912194
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

IVNS1ABP IGSF10 DNAH3 EPB41L4B INTS1 ARID5B IRS1 HUWE1 STOX1 MEGF10

3.59e-06736741029676528
Pubmed

Clearance of HCV improves insulin resistance, beta-cell function, and hepatic expression of insulin receptor substrate 1 and 2.

IRS1 IRS2

4.47e-06274217222321
Pubmed

Roles of Insulin Receptor Substrates (IRS) in renal function and renal hemodynamics.

IRS1 IRS2

4.47e-06274233270683
Pubmed

Some human KIR haplotypes contain two KIR2DL5 genes: KIR2DL5A and KIR2DL5B.

KIR2DL5B KIR2DL5A

4.47e-06274212185535
Pubmed

Roles of insulin receptor substrates in insulin-induced stimulation of renal proximal bicarbonate absorption.

IRS1 IRS2

4.47e-06274215975995
Pubmed

Systematic modeling for the insulin signaling network mediated by IRS(1) and IRS(2).

IRS1 IRS2

4.47e-06274224703981
Pubmed

Differential hepatic distribution of insulin receptor substrates causes selective insulin resistance in diabetes and obesity.

IRS1 IRS2

4.47e-06274227708333
Pubmed

Gene structure and promoter variation of expressed and nonexpressed variants of the KIR2DL5 gene.

KIR2DL5B KIR2DL5A

4.47e-06274211086080
Pubmed

Impairment of bone healing by insulin receptor substrate-1 deficiency.

IRS1 IRS2

4.47e-06274214736890
Pubmed

Impaired insulin signaling in endothelial cells reduces insulin-induced glucose uptake by skeletal muscle.

IRS1 IRS2

4.47e-06274221356519
Pubmed

The study on the relationship between IRS-1 Gly972Arg and IRS-2 Gly1057Asp polymorphisms and type 2 diabetes in the Kurdish ethnic group in West Iran.

IRS1 IRS2

4.47e-06274222994406
Pubmed

Caspase-mediated Cleavage of Insulin Receptor Substrate.

IRS1 IRS2

4.47e-06274215069074
Pubmed

The Irs1 branch of the insulin signaling cascade plays a dominant role in hepatic nutrient homeostasis.

IRS1 IRS2

4.47e-06274219596788
Pubmed

Insulin receptor substrate (IRS)-2, not IRS-1, protects human neuroblastoma cells against apoptosis.

IRS1 IRS2

4.47e-06274219259821
Pubmed

Lack of insulin receptor substrate-2 causes progressive neointima formation in response to vessel injury.

IRS1 IRS2

4.47e-06274212810606
Pubmed

Role of allelic variants Gly972Arg of IRS-1 and Gly1057Asp of IRS-2 in moderate-to-severe insulin resistance of women with polycystic ovary syndrome.

IRS1 IRS2

4.47e-06274211522686
Pubmed

Association of IRS1 (Gly972Arg) and IRS2 (Gly1057Asp) genes polymorphisms with OSA and NAFLD in Asian Indians.

IRS1 IRS2

4.47e-06274234449768
Pubmed

Selective insulin resistance with differential expressions of IRS-1 and IRS-2 in human NAFLD livers.

IRS1 IRS2

4.47e-06274229717275
Pubmed

Increased expression of the sterol regulatory element-binding protein-1 gene in insulin receptor substrate-2(-/-) mouse liver.

IRS1 IRS2

4.47e-06274211546755
Pubmed

Increased insulin resistance in obese children who have both 972 IRS-1 and 1057 IRS-2 polymorphisms.

IRS1 IRS2

4.47e-06274212475767
Pubmed

Variations in insulin secretion in carriers of gene variants in IRS-1 and -2.

IRS1 IRS2

4.47e-06274211872698
Pubmed

Essential role of insulin receptor substrate 1 (IRS-1) and IRS-2 in adipocyte differentiation.

IRS1 IRS2

4.47e-06274211259600
Pubmed

Relationship of insulin receptor substrate-1 and -2 genotypes to phenotypic features of polycystic ovary syndrome.

IRS1 IRS2

4.47e-06274212213887
Pubmed

Selective Insulin Resistance in the Kidney.

IRS1 IRS2

4.47e-06274227247938
Pubmed

Night-Shift Work Duration and Risk of Colorectal Cancer According to IRS1 and IRS2 Expression.

IRS1 IRS2

4.47e-06274231666286
Pubmed

Differential involvement of insulin receptor substrate (IRS)-1 and IRS-2 in brain insulin signaling is associated with the effects on amyloid pathology in a mouse model of Alzheimer's disease.

IRS1 IRS2

4.47e-06274234537327
Pubmed

Insulin Receptor Substrate Adaptor Proteins Mediate Prognostic Gene Expression Profiles in Breast Cancer.

IRS1 IRS2

4.47e-06274226991655
Pubmed

Overexpression of IRS2 in isolated pancreatic islets causes proliferation and protects human beta-cells from hyperglycemia-induced apoptosis.

IRS1 IRS2

4.47e-06274215572028
Pubmed

Insulin receptor substrates are essential for the bioenergetic and hypertrophic response of the heart to exercise training.

IRS1 IRS2

4.47e-06274225002528
Pubmed

Association of KIR2DL5B gene with celiac disease supports the susceptibility locus on 19q13.4.

KIR2DL5B KIR2DL5A

4.47e-06274217215859
Pubmed

Targeting type 2 diabetes: lessons from a knockout model of insulin receptor substrate 2.

IRS1 IRS2

4.47e-06274224977713
Pubmed

Down-regulation of Insulin Receptor Substrate 1 during Hyperglycemia Induces Vascular Smooth Muscle Cell Dedifferentiation.

IRS1 IRS2

4.47e-06274228003360
Pubmed

Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia.

IRS1 IRS2

4.47e-06274211078455
Pubmed

PDGF-induced vascular smooth muscle cell proliferation is associated with dysregulation of insulin receptor substrates.

IRS1 IRS2

4.47e-06274221325637
Pubmed

Oncogenic transformation by the signaling adaptor proteins insulin receptor substrate (IRS)-1 and IRS-2.

IRS1 IRS2

4.47e-06274217374994
Pubmed

Prevalence of the insulin receptor substrate-1(IRS-1) Gly972Arg and the insulin receptor substrate-2(IRS-2) Gly1057Asp polymorphisms in PCOS patients and non-diabetic healthy women.

IRS1 IRS2

4.47e-06274222205343
Pubmed

Insulin Receptor Substrate-1 (IRS-1) and IRS-2 expression levels are associated with prognosis in non-small cell lung cancer (NSCLC).

IRS1 IRS2

4.47e-06274231393907
Pubmed

Myocardial loss of IRS1 and IRS2 causes heart failure and is controlled by p38α MAPK during insulin resistance.

IRS1 IRS2

4.47e-06274224159000
Pubmed

Inhibition of TNF-α improves the bladder dysfunction that is associated with type 2 diabetes.

IRS1 IRS2

4.47e-06274222688336
Pubmed

Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes.

IRS1 IRS2

4.47e-06274215467829
Pubmed

The estrogen receptor alpha:insulin receptor substrate 1 complex in breast cancer: structure-function relationships.

ESR1 IRS1

4.47e-06274217591841
Pubmed

The double life of Irs.

IRS1 IRS2

4.47e-06274218590687
Pubmed

Dynamic functional relay between insulin receptor substrate 1 and 2 in hepatic insulin signaling during fasting and feeding.

IRS1 IRS2

4.47e-06274218590692
Pubmed

Insulin receptor substrate-1/2 mediates IL-4-induced migration of human airway epithelial cells.

IRS1 IRS2

4.47e-06274219447894
Pubmed

Divergent roles for IRS-1 and IRS-2 in breast cancer metastasis.

IRS1 IRS2

4.47e-06274217361103
Pubmed

Disruption of IRS-2 causes type 2 diabetes in mice.

IRS1 IRS2

4.47e-0627429495343
Pubmed

Phosphorylation of insulin receptor substrates (IRS-1 and IRS-2) is attenuated following cecal ligation and puncture in mice.

IRS1 IRS2

4.47e-06274237550630
Pubmed

Insulin receptor substrate 1, but not IRS2, plays a dominant role in regulating pancreatic alpha cell function in mice.

IRS1 IRS2

4.47e-06274233839150
Pubmed

Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice.

IRS1 IRS2

4.47e-06274217928362
Pubmed

The type 2 vascular endothelial growth factor receptor recruits insulin receptor substrate-1 in its signalling pathway.

KDR IRS1

4.47e-06274212153400
Pubmed

Overexpression of insulin receptor substrate-1, but not insulin receptor substrate-2, protects a T cell hybridoma from activation-induced cell death.

IRS1 IRS2

4.47e-06274212055235
Pubmed

Irs1 serine 307 promotes insulin sensitivity in mice.

IRS1 IRS2

4.47e-06274220074531
Pubmed

Role of IRS-2 in insulin and cytokine signalling.

IRS1 IRS2

4.47e-0627427675087
Pubmed

Association of IRS-1 and IRS-2 genes polymorphisms with polycystic ovary syndrome: a meta-analysis.

IRS1 IRS2

4.47e-06274222523112
Pubmed

Decreased lactation capacity and altered milk composition in insulin receptor substrate null mice is associated with decreased maternal body mass and reduced insulin-dependent phosphorylation of mammary Akt.

IRS1 IRS2

4.47e-06274217641282
Pubmed

Association of Gly972Arg variant of insulin receptor subtrate-1 and Gly1057Asp variant of insulin receptor subtrate-2 with polycystic ovary syndrome in the Chinese population.

IRS1 IRS2

4.47e-06274225310961
Pubmed

Association of IRS-1 and IRS-2 polymorphisms with predisposition to type-2 diabetes (T2D): a meta-analysis and trial sequential analysis.

IRS1 IRS2

4.47e-06274237173295
Pubmed

Irs1 and Irs2 signaling is essential for hepatic glucose homeostasis and systemic growth.

IRS1 IRS2

4.47e-06274216374520
Pubmed

Study of association of IRS-1 and IRS-2 genes polymorphisms with clinical and metabolic features in women with polycystic ovary syndrome. Is there an impact?

IRS1 IRS2

4.47e-06274220210696
Pubmed

Developmental and hormonal signals dramatically alter the localization and abundance of insulin receptor substrate proteins in the mammary gland.

IRS1 IRS2

4.47e-06274212746333
Pubmed

Insulin receptor substrates 1 and 2 but not Shc can activate the insulin receptor independent of insulin and induce proliferation in CHO-IR cells.

IRS1 IRS2

4.47e-06274217222824
Pubmed

Polymorphism analysis of the Gly972Arg IRS-1 and Gly1057Asp IRS-2 genes in obese pregnant women.

IRS1 IRS2

4.47e-06274232540195
Pubmed

The IRS-signalling system: a network of docking proteins that mediate insulin action.

IRS4 IRS2

4.47e-0627429609109
Pubmed

Mammary tumorigenesis and metastasis caused by overexpression of insulin receptor substrate 1 (IRS-1) or IRS-2.

IRS1 IRS2

4.47e-06274217030631
Pubmed

Insulin receptor substrate 2 is essential for maturation and survival of photoreceptor cells.

IRS1 IRS2

4.47e-06274215689562
Pubmed

Increased islet cell proliferation, decreased apoptosis, and greater vascularization leading to beta-cell hyperplasia in mutant mice lacking insulin.

KDR IRS1 IRS2

5.08e-061674311897712
Pubmed

Targeted gene mutations define the roles of insulin and IGF-I receptors in mouse embryonic development.

IRS1 IRS2

1.34e-05374210417963
Pubmed

The proto-oncogene product c-Crk associates with insulin receptor substrate-1 and 4PS. Modulation by insulin growth factor-I (IGF) and enhanced IGF-I signaling.

IRS1 IRS2

1.34e-0537428621590
Pubmed

Glucose effects on beta-cell growth and survival require activation of insulin receptors and insulin receptor substrate 2.

IRS1 IRS2

1.34e-05374219273608
Pubmed

The type I interferon receptor mediates tyrosine phosphorylation of insulin receptor substrate 2.

IRS1 IRS2

1.34e-0537428550573
Pubmed

The double-stranded RNA-dependent protein kinase differentially regulates insulin receptor substrates 1 and 2 in HepG2 cells.

IRS1 IRS2

1.34e-05374220685959
Pubmed

Glucokinase and IRS-2 are required for compensatory beta cell hyperplasia in response to high-fat diet-induced insulin resistance.

IRS1 IRS2

1.34e-05374217200721
Pubmed

Upregulation of IRS1 Enhances IGF1 Response in Y537S and D538G ESR1 Mutant Breast Cancer Cells.

ESR1 IRS1

1.34e-05374229029116
Pubmed

Characterization of Drosophila insulin receptor substrate.

IRS1 IRS2

1.34e-05374210801879
Pubmed

IRS-2 Partially Compensates for the Insulin Signal Defects in IRS-1-/- Mice Mediated by miR-33.

IRS1 IRS2

1.34e-05374228190325
Pubmed

IRS-4 mediates protein kinase B signaling during insulin stimulation without promoting antiapoptosis.

IRS4 IRS2

1.34e-05374210594015
Pubmed

Association of insulin receptor H1085H C>T, insulin receptor substrate 1 G972R and insulin receptor substrate 2 1057G/A polymorphisms with refractory temporal lobe epilepsy in Han Chinese.

IRS1 IRS2

1.34e-05374225458098
Pubmed

Structural insights into suppressor of cytokine signaling 1 protein- identification of new leads for type 2 diabetes mellitus.

IRS1 IRS2

1.34e-05374229630758
Pubmed

Aflatoxin B1 induces Src phosphorylation and stimulates lung cancer cell migration.

IRS1 IRS2

1.34e-05374225820822
Pubmed

Insulin receptor substrates differentially exacerbate insulin-mediated left ventricular remodeling.

IRS1 IRS2

1.34e-05374232213702
Pubmed

The insulin-like growth factor-1 pathway mediator genes: SHC1 Met300Val shows a protective effect in breast cancer.

IRS1 IRS2

1.34e-05374215308584
Pubmed

Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2.

IRS1 IRS2

1.34e-05374210642598
Pubmed

Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies.

IRS1 IRS2

1.34e-05374215380067
Pubmed

Nuclear insulin receptor substrate 1 interacts with estrogen receptor alpha at ERE promoters.

ESR1 IRS1

1.34e-05374215318176
Pubmed

Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation.

IRS1 IRS2

1.34e-05374218590693
Pubmed

Differential involvement of the microtubule cytoskeleton in insulin receptor substrate 1 (IRS-1) and IRS-2 signaling to AKT determines the response to microtubule disruption in breast carcinoma cells.

IRS1 IRS2

1.34e-05374228320862
Pubmed

Hepatitis C virus infection in vitro triggers endoplasmic reticulum stress and downregulates insulin receptor substrates 1 and 2 through upregulation of cytokine signaling suppressor 3.

IRS1 IRS2

1.34e-05374225283858
Pubmed

DPP-4 Inhibitor Sitagliptin Improves Cardiac Function and Glucose Homeostasis and Ameliorates β-Cell Dysfunction Together with Reducing S6K1 Activation and IRS-1 and IRS-2 Degradation in Obesity Female Mice.

IRS1 IRS2

1.34e-05374230116740
Pubmed

Identification of a 190-kDa protein as a novel substrate for the insulin receptor kinase functionally similar to insulin receptor substrate-1.

IRS1 IRS2

1.34e-0537427534300
Pubmed

Irs2 and Irs4 synergize in non-LepRb neurons to control energy balance and glucose homeostasis.

IRS4 IRS2

1.34e-05374224567904
Cytoband19p13.3

KIR2DL5B KIR2DL5A FUT6 KHSRP

6.00e-0423774419p13.3
Cytoband1q44

OR2T29 OR2T5 OR2T10

7.67e-041107431q44
Cytoband4q31.21

FREM3 TBC1D9

8.12e-04267424q31.21
CytobandEnsembl 112 genes in cytogenetic band chr1q44

OR2T29 OR2T5 OR2T10

1.19e-03128743chr1q44
Cytoband9q33.3

ZBTB34 LRSAM1

1.65e-03377429q33.3
GeneFamilyAtypical dual specificity phosphatases

DUSP18 EPM2A

8.64e-0418442896
GeneFamilyCD molecules|Killer cell immunoglobulin like receptors

KIR2DL5B KIR2DL5A

8.64e-0418442620
GeneFamilyOlfactory receptors, family 2

OR2T29 OR2T5 OR2T10

2.61e-03113443149
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW09-Neuronal-Cortical_neuron|GW09 / Sample Type, Dataset, Time_group, and Cell type.

ACSL4 CEP85L SPTAN1 AFF3 SYT4 WDR47

8.06e-0720071644bc4d6616fc8d0ad8498e56125939034e8cff01
ToppCelldroplet-Lung-immune-endo-depleted-3m-Lymphocytic-Zbtb32+_B|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

STK32A SLC18A1 ESR1 LRSAM1 FAAH

5.93e-06161715249c2b97cc25de5053f5048ee354615df49b2081
ToppCellfacs-Marrow-B-cells-24m-Myeloid-granulocyte_monocyte_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC18A1 CEP85L ESR1 KDR WDR72

6.68e-061657156d315e0734079ad05336cc2c3f24d870c9105bc8
ToppCellfacs-Marrow-B-cells-24m-Myeloid-granulocyte_monocyte_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC18A1 CEP85L ESR1 KDR WDR72

6.68e-0616571584f5597b1bb75f42de9a224196bb8ac198bbe3bf
ToppCell367C-Lymphocytic-NK_cells-NK_cell_D|367C / Donor, Lineage, Cell class and subclass (all cells)

GFOD1 LRSAM1 BRD7 CEMIP2 STAT4

8.18e-061727156379ae0aca9007c3a8a87e3330908fc90961ad3f
ToppCellTCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Adenocarcinoma_Mixed_Subtype-4|TCGA-Lung / Sample_Type by Project: Shred V9

STK32A CILP ESR1 KDR DCBLD2

9.14e-061767150923b01137d6f9956ca815b41102c81e82624065
ToppCelldroplet-Heart-4Chambers-18m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPHX2 PTPN14 NUAK1 SYT4 CEMIP2

1.10e-051837156c4a09c02e30e1f24dde39f8cb8c5b453826ee2e
ToppCelldroplet-Lung-1m-Endothelial-arterial_endothelial|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

STK32A EPHX2 PTPN14 NUAK1 CEMIP2

1.19e-05186715ffbc78058be8f0dc2e0335cc4c3195a636d17721
ToppCelldroplet-Lung-1m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

STK32A EPHX2 PTPN14 NUAK1 CEMIP2

1.19e-05186715ed924852cd7132c8f6703522037dc22bd2c83193
ToppCellCOVID-19-Epithelial-Ionocytes|COVID-19 / Condition, Lineage and Cell class

PTPN14 MUC16 IRS1 C11orf16 WDR72

1.26e-05188715a581cb9528d0febbf3addbb4f6bc140f91a584e6
ToppCelldroplet-Limb_Muscle-MUSCLE|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CTNNBIP1 CEP85L ARID5B KDR CEMIP2

1.46e-05194715e3d63874111d1e8da3977329426e4dcf68d6de87
ToppCell10x5'-GI_large-bowel-Lymphocytic_T_CD4/8-lo|GI_large-bowel / Manually curated celltypes from each tissue

IVNS1ABP GFOD1 SURF4 IRS2 CEMIP2

1.58e-051977152d7054234759a8dea525c26b3f7aae539ef7624c
ToppCell10x5'-GI_large-bowel-Lymphocytic_T_CD4/8-lo-Trm_Tgd|GI_large-bowel / Manually curated celltypes from each tissue

IVNS1ABP GFOD1 SURF4 IRS2 CEMIP2

1.58e-051977158546ddf096a1ca8c897b40d496bc507d79ac520e
ToppCell356C-Lymphocytic-NK_cells-NK_cell_A|NK_cells / Donor, Lineage, Cell class and subclass (all cells)

GFOD1 ARID5B IRF8 IRS2 CEMIP2

1.61e-05198715ec115c4a5dbc54206c72140aa0c8d6a7c29c5563
ToppCell390C-Lymphocytic-NK_cells-NK_cell_A|NK_cells / Donor, Lineage, Cell class and subclass (all cells)

IVNS1ABP GFOD1 IRF8 CNOT2 CEMIP2

1.61e-05198715a1c8e5c332336823c47c04e56b6d7bc8f057c9da
ToppCelllymphoid-NK_cell-NK_cell|NK_cell / Lineage, cell class and subclass

SURF4 IRF8 CNOT2 CEMIP2 STAT4

1.65e-05199715945fbf5845403a8b22d04963f50ad69c414b6153
ToppCellSevere-B_naive-4|Severe / disease group and sub_cluster of B and Plasma cells(res = 0.5)

AFF3 IRF8 IRS2 ARPC3 CEMIP2

1.65e-05199715e02e482cca6a00d2980e750bca6de598819aa1b2
ToppCell390C-Lymphocytic-NK_cells-NK_cell_A|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

IVNS1ABP GFOD1 IRF8 CNOT2 CEMIP2

1.69e-0520071548ca9269ee3962d13408fef12b5be120759eac52
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW10-Neuronal-Cortical_neuron|GW10 / Sample Type, Dataset, Time_group, and Cell type.

GFOD1 CEP85L SPTAN1 AFF3 SYT4

1.69e-05200715458fb0f40c1720f1cacedf78c40bd059692bfc62
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW16-Neuronal-Cortical_neuron|GW16 / Sample Type, Dataset, Time_group, and Cell type.

CEP85L SPTAN1 AFF3 SYT4 WDR47

1.69e-0520071519055194a5e0ea122f1b8fc62df44813f6843c95
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Myh8_Fibin|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

STK32A IRS4 ESR1 STK32B

3.22e-05113714feb3c6a7723263d58e5ce020a0097fedfcf78ca8
ToppCellNS-critical-d_0-4-Myeloid-pDC|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

ORC1 AFF3 IRF8 IRS1

8.28e-051447140fde5cd82df9b90aefde19275cff6c2ec3c9d5cb
ToppCellTCGA-Breast|World / Sample_Type by Project: Shred V9

CILP ESR1 AFF3 TBC1D9

9.69e-0515071408686ba1acac5c58667bf62e2af84c691d6bbdfb
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW10-OPC_related-Oligodendrocyte/OPC|GW10 / Sample Type, Dataset, Time_group, and Cell type.

AURKC CILP OTOF GPR156

9.95e-051517144533bccc996395f74b16af939ce79b6fe253c073
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW10-OPC_related|GW10 / Sample Type, Dataset, Time_group, and Cell type.

AURKC CILP OTOF GPR156

9.95e-05151714edb2f59789c295838d2030b80c792cbea25eaa3d
ToppCellfacs-Liver-Non-hepatocytes-3m-Endothelial-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KDR VWA5B1 MEGF10 CEMIP2

1.10e-041557148fdda4e3657ac56188ae88ed3caf145f4d9d1567
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L2/3_IT-L2/3_IT_VISp_Agmat|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

DUSP18 PTPN14 OTOF STAT4

1.13e-0415671409e0702400570089d9012dcf94dfb4827c97e49d
ToppCellfacs-Trachea-3m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l7|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

IRS4 CTNNBIP1 KDR VWA5B1

1.18e-0415871478b48b110b777bcc4c07cd23388bee911c0231d6
ToppCellIPF-Epithelial-Ionocyte|World / Disease state, Lineage and Cell class

EPB41L4B MUC16 SYT4 C11orf16

1.27e-04161714f1cd5c938cdc08ad8995371b72493850a6cf277a
ToppCellPosterior_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Sst-Inhibitory_Neuron.Gad1Gad2.Sst-Nr2f2_(Neuron.Gad1Gad2.Sst-Nr2f2)-|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

STK32A TNNI3K IRS4

1.33e-04627139db88da996b9977f5a89afe505cd55e7b5324bc9
ToppCellFrontal_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Sst-Inhibitory_Neuron.Gad1Gad2.Sst-Nr2f2_(MGE-derived_cortical_interneurons--Martinotti_cells)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

TNNI3K IRS4 CILP

1.33e-0462713a20620a8869721ea62984c2022ee1b484b455824
ToppCellFrontal_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Sst-Inhibitory_Neuron.Gad1Gad2.Sst-Nr2f2_(MGE-derived_cortical_interneurons--Martinotti_cells)-|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

TNNI3K IRS4 CILP

1.33e-0462713ee694c06bcd924b4ddf744178ba3a99e04eed51b
ToppCellPosterior_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Sst-Inhibitory_Neuron.Gad1Gad2.Sst-Nr2f2_(Neuron.Gad1Gad2.Sst-Nr2f2)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

STK32A TNNI3K IRS4

1.33e-0462713461d280a1b955033186cfc326f9ace85b4a53c54
ToppCelldroplet-Lung-immune-endo-depleted-3m-Lymphocytic-B_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

STK32A SLC18A1 ESR1 LRSAM1

1.40e-0416571422293c6b55f44636440cd737efb786ff5de3373d
ToppCellPND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

IVNS1ABP STK32A PTPN14 CEMIP2

1.43e-041667147a45785a40b7425f97be67bab1c5ceb69b2bd85a
ToppCellPND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

IVNS1ABP STK32A PTPN14 CEMIP2

1.43e-04166714bbd382812f8a84a5d99888de2d7cca3a8b5e4695
ToppCell3'_v3-GI_small-bowel-Lymphocytic_B-Memory_B_cells|GI_small-bowel / Manually curated celltypes from each tissue

AFF3 ARID5B IRF8 TBC1D9

1.50e-041687148e025bb0541746e232b77ac0e31412ae71420c47
ToppCell3'_v3-GI_small-bowel-Lymphocytic_B|GI_small-bowel / Manually curated celltypes from each tissue

AFF3 ARID5B IRF8 TBC1D9

1.50e-041687145535c1b8b7fde7b59a1bc0580cebdfa963aa1c39
ToppCellSevere-B_naive-11|Severe / disease group and sub_cluster of B and Plasma cells(res = 0.5)

AFF3 IRF8 ARPC3 CEMIP2

1.60e-041717147c2699f19ca38414447a286f7658f507882d57c2
ToppCellCOVID-19_Severe-NK_CD56bright|COVID-19_Severe / Disease condition and Cell class

GFOD1 CTNNBIP1 AFF3 IRF8

1.60e-041717145810f790012a0750ca3378595514f66a99f123be
ToppCellASK452-Endothelial-Lymphatic|ASK452 / Donor, Lineage and Cell class of Lung cells from Dropseq

PRPF40B CEP85L STARD9 KDR

1.79e-04176714b4d280ecc07701d526f50d44c45ea91b3eeb00b1
ToppCelldroplet-Limb_Muscle-MUSCLE-30m-Endothelial|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CTNNBIP1 CEP85L IRF8 KDR

1.83e-04177714ca5a30b3e7bcfdd8de01ceaf7449735b5cd503af
ToppCelldroplet-Limb_Muscle-MUSCLE-30m-Endothelial-nan|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CTNNBIP1 CEP85L IRF8 KDR

1.83e-04177714f471f7747d6e8db7546899019af9508f48a14f89
ToppCelldroplet-Limb_Muscle-MUSCLE-30m-Endothelial-endothelial_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CTNNBIP1 CEP85L IRF8 KDR

1.83e-04177714cd0684b876c2a7d5fe7e2773e8e25bb61ecbc795
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_B-B_cell-B_c02-MS4A1-CD27|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

AFF3 IRF8 SYT4 TBC1D9

1.83e-0417771437d1abe1a9d8f2b8f4d146bbf1db94104eab6593
ToppCellAdult-Endothelial-endothelial_cell_of_bronchial_vessel-D175|Adult / Lineage, Cell type, age group and donor

AURKC GFOD1 STK32B KDR

1.83e-04177714c9f269765c7d5d29caab75910e51645606ed562e
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

IVNS1ABP STK32A ACSL4 TBC1D9

1.83e-04177714c9e8149639551a4c8daa90fcb2b895fdcff2e2ba
ToppCelldroplet-Heart-4Chambers-18m-Endothelial-coronary_vascular_endothelial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CTNNBIP1 ARID5B SYT4 KDR

1.87e-04178714ba2f0585626988b511046630bc16be5c5fec3fb2
ToppCellTCGA-Liver-Primary_Tumor-Hepatocellular_Carcinoma-Hepatocellular_Carcinoma-1|TCGA-Liver / Sample_Type by Project: Shred V9

DUSP18 PTPN14 PIGS WDR47

1.87e-0417871451c59dabf2d7aef1b1964f6f766d5ec07ef90f5a
ToppCellhuman_hepatoblastoma-Tumor_cells-T6|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

NUAK1 CEP85L ESR1 CEMIP2

1.91e-0417971414fc8ccb6b215063d747643f47d780d2b237eb67
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

IVNS1ABP STK32A ACSL4 TBC1D9

1.91e-04179714666072c0e8448dbaec1683d18368ec2502453f90
ToppCellIPF-Lymphoid-B|World / Disease state, Lineage and Cell class

AFF3 ARID5B IRF8 CEMIP2

1.95e-0418071430f9398c9b784f49470847a025bac90687e997a1
ToppCellfacs-Lung-Endomucin-3m-Endothelial-Artery_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

STK32A EPHX2 NUAK1 CEMIP2

2.04e-04182714aa113a0d2c1d28bda24cbb1221afd21b5628dc6d
ToppCellIPF-Lymphoid-B|IPF / Disease state, Lineage and Cell class

AFF3 ARID5B IRF8 CEMIP2

2.08e-04183714e37d2c015c34471a8a54a0299e94b0371e1ada5a
ToppCellCOVID-19-kidney-PCT-S1|COVID-19 / Disease (COVID-19 only), tissue and cell type

STK32B OR2T10 FUT6 WDR72

2.08e-041837146878d14026c3df6aa12e45dfad94b32fa9d9b0b7
ToppCellE18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_prolif|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DUSP18 CEP85L AFF3 IRS1

2.12e-04184714a6dee97ee4ef9d89e11d17339e0dadaea1210ce5
ToppCelldroplet-Limb_Muscle-nan-18m-Macroglial-unknown|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

STK32A EPB41L4B GPR156 MEGF10

2.12e-04184714a7399a72f065d68800e3e0b2031d9894e0cc0ba4
ToppCellPBMC-Severe-Lymphocyte-B-B_cell-B_memory-B_memory-3|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

AFF3 ARID5B IRF8 OR2T10

2.17e-0418571491c9a3ea1afd97d35bd05648875d29b35fe09128
ToppCellCOPD-Lymphoid-B|COPD / Disease state, Lineage and Cell class

AFF3 ARID5B IRF8 CEMIP2

2.17e-04185714925e79c35c381dd44ec5fb921dca09ce43140135
ToppCelldroplet-Liver-LIVER_HEP-30m-Endothelial-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IGSF10 PTPN14 KDR CEMIP2

2.17e-04185714bdd2e6cb20294b39a9d856004bf57ba69cf877e2
ToppCellSmart-seq2-spleen_(Smart-seq2)-lymphocytic-innate_lymphocytic|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

NUAK1 GFOD1 CEMIP2 STAT4

2.21e-04186714fc0b488c201a32d829047b58460297df2818b45d
ToppCellP28-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_vein|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

PTPN14 NUAK1 PRPF40B CEMIP2

2.21e-04186714153c8b2fd8a6e2141ca97c626f82e5f081f3180a
ToppCelldroplet-Heart-nan-3m-Endothelial|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTPN14 CEP85L KDR CEMIP2

2.21e-041867140ae5fbe9f210cb25092394267e1d3d6ed05627b8
ToppCellPBMC-Severe-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-10|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

AFF3 IRF8 TBC1D9 CEMIP2

2.21e-04186714d7d884ff4184636081c350d29f797bd923c6a3b4
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

STK32A EPHX2 EPM2A STK32B

2.26e-04187714b93cf4dfe8ffb89348ee7bccc9f284189f7240a2
ToppCell10x_3'_v3-bone_marrow_(10x_3'_v3)-lymphocytic-B_lymphocytic-memory_B_cell|bone_marrow_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

AFF3 ARID5B IRF8 TBC1D9

2.26e-04187714b5cb8760fa667c237902d50a78dea4cb1babd607
ToppCellHealthy_donor-B_memory|World / disease group, cell group and cell class (v2)

AFF3 ARID5B MUC16 TBC1D9

2.26e-041877144f68e3243071a4549c80aff8bff32c6ad892ee7f
ToppCell3'-Adult-Appendix-Endothelial-blood_vessel_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PTPN14 NUAK1 GFOD1 KDR

2.26e-0418771437d8ee5c8bd6324749e5a2adef1d0482c75da80c
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell__prolif|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NUAK1 GFOD1 STARD9 KDR

2.26e-0418771435c382c0aabd46906113e5db30ea24bb8e658899
ToppCellfacs-Heart-LA-24m-Endothelial-endothelial_cell_of_endocardium|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPHX2 PTPN14 NUAK1 CEMIP2

2.26e-04187714d9943e65eedab73d141eae524e2411653a751705
ToppCell3'-Adult-Appendix-Endothelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PTPN14 NUAK1 GFOD1 KDR

2.26e-04187714ec98d5e480b08854dfd0ba6b1dc6610455f90640
ToppCelldroplet-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l30|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

EPHX2 DUSP18 EPB41L4B WDR47

2.26e-041877148e8b147258982b359447add5027318f5b6d51963
ToppCellfacs-Heart-LA-24m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPHX2 PTPN14 NUAK1 CEMIP2

2.26e-041877147b13c3b67d66f3afb410141d5471c9e78a4d8623
ToppCellSmart-seq2-spleen_(Smart-seq2)-lymphocytic-innate_lymphocytic-mature_NK_T_cell|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

NUAK1 GFOD1 CEMIP2 STAT4

2.26e-041877146981b856187a2e689260ecb7d0a1193a374ee9b9
ToppCelldroplet-Limb_Muscle-nan-18m-Macroglial-Schwann_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

STK32A EPB41L4B GPR156 MEGF10

2.31e-041887148385fd384fc55e3b17802bb6698eb93b2c16d7f2
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8|GI_small-bowel / Manually curated celltypes from each tissue

CEP85L HUWE1 CEMIP2 STAT4

2.31e-04188714ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCellnormal-na-Lymphocytic_B-B_naive-male|normal / PBMC cell types (v2) per disease, treatment status, and sex

AFF3 ARID5B IRF8 CEMIP2

2.31e-04188714ec72ba73b10c6f2ff39699b6b46b90a3e95a4c24
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

IVNS1ABP STK32A ACSL4 STK32B

2.31e-041887142ee64bc73a2251fd9f374be759b442cf4ed0d19e
ToppCell10x5'-GI_small-bowel-Lymphocytic_B-Memory_B_cells|GI_small-bowel / Manually curated celltypes from each tissue

AFF3 ARID5B IRF8 TBC1D9

2.31e-04188714ab1384e6f71053946368502282aeebf1ba92d33e
ToppCelldroplet-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l32-30|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

STK32A EPB41L4B GPR156 MEGF10

2.31e-04188714502045a39ffb1e92bd9499848368e8fa971edb88
ToppCellP28-Endothelial-large_vessel_endothelial_cell|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

IVNS1ABP STK32A PTPN14 CEMIP2

2.31e-04188714263169029293e005bcffd87db20221fdd2d3917e
ToppCelldroplet-Limb_Muscle-nan-18m-Macroglial|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

STK32A EPB41L4B GPR156 MEGF10

2.31e-04188714cb9d0b48e2fd9cc576132803273b9c0382900944
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

IVNS1ABP STK32A ACSL4 STK32B

2.35e-04189714f51cdc9a47371cab8ed9ae63a6f14da07ede446c
ToppCelldroplet-Heart-nan-3m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPHX2 PTPN14 NUAK1 CEMIP2

2.35e-041897148e583ec4df0f5b79ce5211cc99ecd8616d180bde
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

EPHX2 CEP85L SPTAN1 STAT4

2.35e-041897149ab77c6fcb573854da5922412f53d2168bda6b58
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

IVNS1ABP ACSL4 PTPN14 STK32B

2.35e-04189714e059be2965cca70ff5576df055d0af1775b76e00
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

EPHX2 CEP85L SPTAN1 STAT4

2.35e-041897145a9e2ca9a9ee2dc37ab9147a902115a9f1a80169
ToppCelldroplet-Heart-nan-3m-Endothelial-endocardial_endothelial_cells|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPHX2 PTPN14 NUAK1 CEMIP2

2.35e-04189714fb2253b8463d08b3d28e952a31a23dea2c2d986b
ToppCelldroplet-Lung-1m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l27|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

STK32A EPHX2 PTPN14 NUAK1

2.40e-041907143b9abc25b17e7295356ded57ff2ca519fa9f2686
ToppCellChildren_(3_yrs)-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

GFOD1 STARD9 AFF3 KDR

2.40e-041907140e9847d7f49b2236b8a191e1a7df37556351ba9e
ToppCellP15-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_vein|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

PTPN14 NUAK1 PRPF40B CEMIP2

2.40e-04190714d072bb285bd34d518b958e7c9ad44739c60b359c
ToppCellfacs-Lung-nan-3m-Mesenchymal-pulmonary_interstitial_fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IGSF10 IRS2 FREM3 MEGF10

2.40e-04190714c7bd087f36321cec61b98657433b4d19d135791f
ToppCellfacs-Lung-nan-3m-Mesenchymal-Myofibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IGSF10 IRS2 FREM3 MEGF10

2.40e-04190714834218fcc59df5e7e52de154272f3d55d81d0dac
ToppCellCOPD-Lymphoid-B|Lymphoid / Disease state, Lineage and Cell class

AFF3 ARID5B IRF8 TBC1D9

2.40e-041907141e85ee686ff6dd27c69415d524d54fa825b1daad
ToppCellPBMC-Control-Lymphocyte-B-B_cell-B_memory|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

AFF3 ARID5B IRF8 TBC1D9

2.45e-0419171403f6da73e7b706252d2096507222229c4101a27b
ToppCellPBMC-Control-Lymphocyte-B-B_cell-B_memory-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

AFF3 ARID5B IRF8 TBC1D9

2.45e-04191714578b58782e816ecaeabfbc616ceb1dcd53ee428b
ToppCellB_cell_maturation-Memory_B_cell|World / Lineage and Cell class

ARID5B IRF8 ARPC3 TBC1D9

2.45e-04191714528c3dea44238233dc1aa8d6ba5c3a191d18d985
ToppCellChildren_(3_yrs)-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)|Children_(3_yrs) / Lineage, Cell type, age group and donor

GFOD1 STARD9 AFF3 KDR

2.45e-04191714f229abf69a1217194f74b0502486907e07dba989
ToppCellfacs-Lung-3m-Endothelial-arterial_endothelial|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

STK32A EPHX2 NUAK1 CEMIP2

2.45e-041917146e6b2cb390cc5cd0356924a2c36fbe5b5bd5966c
ToppCellfacs-Lung-3m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

STK32A EPHX2 NUAK1 CEMIP2

2.45e-04191714482db995930346be69072ace2fd78fd453e97fb5
Diseaseamnestic disorder (implicated_via_orthology)

IRS4 IRS1 IRS2

1.02e-069693DOID:10914 (implicated_via_orthology)
Diseaseosteoporosis (biomarker_via_orthology)

ESR1 IRS1 IRS2

1.83e-0522693DOID:11476 (biomarker_via_orthology)
DiseaseLiver carcinoma

ACSL4 ORC1 ESR1 DEPDC5 IRS1 IRS2 TST STAT4

2.40e-05507698C2239176
Diseaseintellectual disability (implicated_via_orthology)

ZNF280A IRS4 IRS1 IRS2

2.94e-0575694DOID:1059 (implicated_via_orthology)
Diseaseglucose metabolism disease (implicated_via_orthology)

IRS4 IRS1 IRS2

3.84e-0528693DOID:4194 (implicated_via_orthology)
Diseasetype 2 diabetes mellitus (implicated_via_orthology)

IRS4 AFF3 IRS1 IRS2

1.10e-04105694DOID:9352 (implicated_via_orthology)
Diseaseoccupational attainment

ESR1 AFF3 SYT4

1.32e-0442693EFO_0020977
DiseaseMalignant neoplasm of breast

PTPN14 OTOF CEP85L ESR1 PIGS SPTAN1 IRF8 KDR FAAH STAT4

1.89e-0410746910C0006142
DiseaseMental Retardation, X-Linked Nonsyndromic

ACSL4 HUWE1

4.13e-0413692C3501611
Diseaseattention deficit hyperactivity disorder, substance abuse, antisocial behaviour measurement

TNNI3K EPM2A PRPF40B ESR1 AFF3 ARID5B SYT4 CEMIP2

5.52e-04801698EFO_0003888, EFO_0007052, MONDO_0002491
Diseaseamyotrophic lateral sclerosis, age at onset

SLC18A1 CNOT2

5.55e-0415692EFO_0004847, MONDO_0004976
Diseasephosphatidylcholine 38:6 measurement

DEPDC5 TMEM258

6.33e-0416692EFO_0010388
Diseasetotal blood protein measurement

DNAH3 SLC18A1 ESR1 AFF3 ARID5B CEMIP2

6.41e-04449696EFO_0004536
Diseaserheumatoid arthritis, anti-citrullinated protein antibody seropositivity, rheumatoid factor seropositivity measurement

AFF3 ARID5B TMEM258 STAT4

6.87e-04170694EFO_0000685, EFO_0007791, EFO_0007837
Diseaserheumatoid arthritis

ZBTB34 NUAK1 AFF3 ARID5B TMEM258 STAT4

7.43e-04462696EFO_0000685
DiseaseRheumatoid Arthritis

AFF3 ARID5B IRF8 STAT4

7.49e-04174694C0003873
Diseaseselenium measurement, response to dietary selenium supplementation

SLC18A1 GPR156

9.96e-0420692EFO_0006331, EFO_0600021
Diseasesystemic scleroderma (is_implicated_in)

ESR1 STAT4

1.44e-0324692DOID:418 (is_implicated_in)
Diseasecoronary artery disease (is_implicated_in)

EPHX2 ESR1 IRS1

1.68e-03100693DOID:3393 (is_implicated_in)
DiseaseVitiligo

ARID5B IRF3 STAT4

1.73e-03101693EFO_0004208
Diseasemacular degeneration (is_implicated_in)

ESR1 KDR

1.82e-0327692DOID:4448 (is_implicated_in)
Diseaseosteoarthritis (is_implicated_in)

CILP ESR1

1.96e-0328692DOID:8398 (is_implicated_in)
DiseaseTYPE 2 DIABETES MELLITUS

IRS1 IRS2

1.96e-0328692125853
Diseaselumbar disc degeneration

PPP1R2P1 STOX1

1.96e-0328692EFO_0004994
DiseaseType 2 diabetes mellitus

IRS1 IRS2

1.96e-0328692cv:C0011860
DiseaseMarijuana Abuse

ESR1 FAAH

2.25e-0330692C0024809

Protein segments in the cluster

PeptideGeneStartEntry
TMKSSSEPGYKMSSP

ZNF280A

116

P59817
GPMESKSPYTMYSET

AFF3

1021

P51826
RPTPSDMAIVMYTSG

ACSL4

266

O60488
RKTMCGTLDYLPPEM

AURKC

196

Q9UQB9
PGYSMIIKHPMDFST

BRD7

166

Q9NPI1
TMYMELPNAKPRSLS

KIR2DL5A

326

Q8N109
KESSMPAVTYTPAMR

MEGF10

886

Q96KG7
VAMTPTYMDSPRKDG

DEPDC5

1076

O75140
RMAYSSGSSPEMTAP

MUC16

1296

Q8WXI7
PKATSPMGTTYTMGE

MUC16

8376

Q8WXI7
PMTPDTMIKLYREEG

EPM2A

211

O95278
PLTAAEMAPYMKRLS

INTS1

2041

Q8N201
LIEKPMSPMQYARSG

IVNS1ABP

346

Q9Y6Y0
EMLSLDASAMVYPPR

LRSAM1

176

Q6UWE0
MKIDEPSTPYHSTMG

PPP1R2P1

66

Q96PQ5
TMYMELPNAKPRSLS

KIR2DL5B

326

Q8NHK3
YDPTRPFSEASMMGL

ESR1

331

P03372
SVDDYMGMIKRSPSP

IRF8

151

Q02556
PSSYHTPEKDMMVSV

OR2T5

266

Q6IEZ7
DPLEMVMTGAYSKPT

LILRB3

111

O75022
YTRPPTTFPMDKMVA

OR4C11

256

Q6IEV9
RKGSGDYMPMSPKSV

IRS1

626

P35568
PSEIMESLTKMYSIP

HUWE1

236

Q7Z6Z7
LPSSYQTPEKDMMSS

OR2T10

261

Q8NGZ9
PSSYHTPEKDMMVSV

OR2T29

266

Q8NH02
CRMEGLPYPTMSETM

ORC1

806

Q13415
RSDDYMPMSPASVSA

IRS2

671

Q9Y4H2
SPAESSPEDSGYMRM

IRS2

731

Q9Y4H2
AVMTYAPTSIPMEKT

IGSF10

1141

Q6WRI0
MDMKGYGESSAPPEI

EPHX2

291

P34913
SPATVSRCGMIYMEP

DNAH3

1841

Q8TD57
MPAYHSSLMDPDTKL

ARPC3

1

O15145
MTSSEAFEPPKYLML

CEP85L

266

Q5SZL2
LSMTITRDEYPSNPM

CEMIP2

1006

Q9UHN6
KPLPQGTMMETLSRY

FUT6

226

P51993
MPLSKELGFSPYMVR

GPR156

586

Q8NFN8
ETDNYTMPSPAMRRA

FAAH

331

O00519
EYATPIIMDMSGHPT

DCBLD2

676

Q96PD2
SLPMKEETTGVCMYP

EPB41L4B

786

Q9H329
KVMMVALGRSPSDEY

MRTO4

71

Q9UKD2
DIKMEPSAGRPMDYQ

OTOF

241

Q9HC10
PDPGMSLTDRGVMSY

IRF3

246

Q14653
GVATPLVSSSDYMPM

IRS4

706

O14654
SSLLPQDMMSYIGPK

PIGS

151

Q96S52
PRTSMTEEYRVPDGM

KHSRP

141

Q92945
ATSSPNRDYVPMMVE

FREM3

256

P0C091
PAMDEQSMTSDPYIK

SYT4

181

Q9H2B2
SDIPSPYLRGTIKMM

GFOD1

296

Q9NXC2
PTPDYETVMRQMKRG

PTPN14

441

Q15678
YSAGTMDPALVSPEM

NUAK1

531

O60285
MFAGVPTMRESSPKQ

SURF4

141

O15260
YDTSMPRPSRKMVRG

STARD9

4626

Q9P2P6
AGTKPYMAPEMFSSR

STK32A

181

Q8WU08
TMDYRGTMIPSEAPL

MRPL24

101

Q96A35
RVSPMTMSGPKKYPE

ARID5B

956

Q14865
AETPYMVMNPETKAR

CILP

306

O75339
MNREGAPGKSPEEMY

CTNNBIP1

1

Q9NSA3
MESSTGPRMPLLKYC

C11orf16

1

Q9NQ32
RAPGMEPTMKTNTYE

CNOT2

481

Q9NZN8
SSPMRRPQSADAYMT

WDR47

296

O94967
YDMSTVMSRKGPAPE

SF3B2

806

Q13435
LPSDESRLMPASMTY

STOX1

206

Q6ZVD7
EQSTKMTYEGDPIPM

STAT4

281

Q14765
YGMMPRDETDSKTAS

SPTAN1

1176

Q13813
IRMMGKPLTSASDYE

TBC1D9

1246

Q6ZT07
MEKSTPYECGFDPMS

MT-ND3

31

P03897
SRPFVMGYMNERKEP

WDR72

321

Q3MJ13
AMKMVVTDPRYSALP

PRPF40B

301

Q6NWY9
RASSMAGTKPYMAPE

STK32B

176

Q9NY57
EGTRMRAPDYTTPEM

KDR

1121

P35968
MELEAMSRYTSPVNP

TMEM258

1

P61165
DTASPYEMMLPSEAG

TST

66

Q16762
PIDKYGYVSDPMSSM

TNNI3K

806

Q59H18
MMNNPGYESSPRERS

ZBTB34

346

Q8NCN2
RATMASDPMPAAKRY

VWA5B1

671

Q5TIE3
PMETRMYATQKPTKE

SLC18A1

496

P54219
MVSSPVGMIPDIYEK

DUSP18

166

Q8NEJ0