Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionmetalloendopeptidase activity

ADAMTS12 MMP13 ADAMTSL2

4.42e-04120253GO:0004222
GeneOntologyMolecularFunctionfibronectin binding

IGFBP6 MMP13

1.03e-0338252GO:0001968
GeneOntologyMolecularFunctionendopeptidase activity

ADAMTS12 MMP13 HP ADAMTSL2

1.87e-03430254GO:0004175
GeneOntologyMolecularFunctionmetallopeptidase activity

ADAMTS12 MMP13 ADAMTSL2

1.94e-03200253GO:0008237
GeneOntologyCellularComponentextracellular matrix

ADAMTS12 CFP FCGBP IGFBP6 MMP13 ADAMTSL2

9.93e-05656256GO:0031012
GeneOntologyCellularComponentexternal encapsulating structure

ADAMTS12 CFP FCGBP IGFBP6 MMP13 ADAMTSL2

1.01e-04658256GO:0030312
GeneOntologyCellularComponenttertiary granule lumen

CFP HP

1.96e-0355252GO:1904724
GeneOntologyCellularComponentspecific granule lumen

CFP HP

2.48e-0362252GO:0035580
DomainTSP_1

ADAMTS12 CFP ADAMTSL2

7.04e-0563243PF00090
DomainTSP1

ADAMTS12 CFP ADAMTSL2

7.73e-0565243SM00209
DomainTSP1_rpt

ADAMTS12 CFP ADAMTSL2

7.73e-0565243IPR000884
DomainTSP1

ADAMTS12 CFP ADAMTSL2

7.73e-0565243PS50092
DomainVWFD

FCGBP VWDE

1.88e-0416242PS51233
DomainVWD

FCGBP VWDE

1.88e-0416242SM00216
DomainVWF_type-D

FCGBP VWDE

1.88e-0416242IPR001846
DomainVWD

FCGBP VWDE

1.88e-0416242PF00094
DomainPLAC

ADAMTS12 ADAMTSL2

2.67e-0419242IPR010909
DomainPLAC

ADAMTS12 ADAMTSL2

2.67e-0419242PS50900
DomainADAM_spacer1

ADAMTS12 ADAMTSL2

3.94e-0423242IPR010294
DomainADAM_spacer1

ADAMTS12 ADAMTSL2

3.94e-0423242PF05986
DomainPeptidase_M12B_ADAM-TS

ADAMTS12 ADAMTSL2

4.29e-0424242IPR013273
DomainCYSTEINE_SWITCH

ADAMTS12 MMP13

1.26e-0341242PS00546
DomainPept_M10_metallopeptidase

ADAMTS12 MMP13

1.38e-0343242IPR001818
DomainZinc_finger_PHD-type_CS

RSF1 NFX1

3.13e-0365242IPR019786
DomainEGF

FCGBP LRP1B VWDE

3.27e-03235243SM00181
DomainEGF-like_dom

FCGBP LRP1B VWDE

3.85e-03249243IPR000742
DomainZnf_PHD-finger

RSF1 NFX1

4.59e-0379242IPR019787
DomainMetalloPept_cat_dom

ADAMTS12 MMP13

4.82e-0381242IPR024079
Domain-

ADAMTS12 MMP13

4.82e-03812423.40.390.10
DomainZINC_PROTEASE

ADAMTS12 MMP13

6.98e-0398242PS00142
DomainGrowth_fac_rcpt_

IGFBP6 LRP1B

1.70e-02156242IPR009030
PathwayREACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS

ADAMTS12 CFP ADAMTSL2

8.71e-0639153MM15165
PathwayREACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS

ADAMTS12 CFP ADAMTSL2

8.71e-0639153M27417
PathwayREACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS

ADAMTS12 CFP ADAMTSL2

4.69e-0568153M27303
PathwayREACTOME_DISEASES_OF_METABOLISM

ADAMTS12 CFP BTD ADAMTSL2

1.13e-04250154M27554
PathwayREACTOME_O_LINKED_GLYCOSYLATION

ADAMTS12 CFP ADAMTSL2

1.91e-04109153MM15164
PathwayREACTOME_O_LINKED_GLYCOSYLATION

ADAMTS12 CFP ADAMTSL2

2.02e-04111153M27416
PathwayREACTOME_DISEASES_OF_GLYCOSYLATION

ADAMTS12 CFP ADAMTSL2

4.25e-04143153M27275
PathwayWP_TGFBETA_RECEPTOR_SIGNALING_IN_SKELETAL_DYSPLASIAS

TGFBR3 ADAMTSL2

1.75e-0359152M39886
Pubmed

O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.

ADAMTS12 CFP ADAMTSL2

2.42e-057526320637190
Pubmed

Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

CFP FCGBP HP BTD

3.83e-0525726416335952
Pubmed

Human colostrum: identification of minor proteins in the aqueous phase by proteomics.

TGFBR3 HP BTD

2.38e-0416226316502470
Pubmed

Interferon gamma receptor 2 gene variants are associated with liver fibrosis in patients with chronic hepatitis C infection.

TGFBR3 MMP13

3.33e-043626220587546
Pubmed

Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry.

FCGBP HP

4.33e-044126216740002
InteractionTAFA2 interactions

TGFBR3 VWDE BTD

2.64e-0547253int:TAFA2
Cytoband2q21.2

NCKAP5 LRP1B

2.79e-05142622q21.2
CytobandEnsembl 112 genes in cytogenetic band chr7p21

DGKB VWDE

1.17e-0389262chr7p21
GeneFamilyPHD finger proteins

RSF1 NFX1

3.56e-039018288
ToppCellLPS_only-Endothelial-Endothelial-Vein|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TGFBR3 ABLIM1 IGFBP6 LRP1B

3.79e-0619225452acaecd3703166f5ce3b328aff7c82bd142fee4
ToppCellLA|World / Chamber and Cluster_Paper

TGFBR3 IGFBP6 HP LRP1B

3.87e-06193254d4bf89437216baf489ea0239136dcedf3b6714af
ToppCellIPF-Stromal-Fibroblast|Stromal / Disease state, Lineage and Cell class

TGFBR3 ABLIM1 IGFBP6 ABTB2

3.95e-06194254da3e1d39575969a069ef43e552afe94b2f441d0b
ToppCell3'-Adult-LymphNode-Mesenchymal-fibroblastic-mLN_Stroma_(FMO2+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TGFBR3 IGFBP6 LRP1B ADAMTSL2

4.28e-06198254abac765c4f6864bdb1700bc546c3b9771edc25c3
ToppCell3'-Adult-LymphNode-Mesenchymal-fibroblastic|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TGFBR3 IGFBP6 LRP1B ADAMTSL2

4.28e-06198254ff57addcbdd53e5d2d0c80ec76b5eab3b3a67ca2
ToppCell3'-Adult-LymphNode-Mesenchymal|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TGFBR3 IGFBP6 LRP1B ADAMTSL2

4.28e-06198254698166b4ca173176ed563af6a1efc8c7d0a18e0b
ToppCellParenchymal-10x5prime-Epithelial-Epi_submucosal-gland|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

WFDC3 FCGBP GPT2

2.98e-0510825375d635fc5bb004418db2e1328c24d96b718f10b1
ToppCellParenchymal-10x5prime-Epithelial-Epi_submucosal-gland-SMG_Duct|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

WFDC3 FCGBP GPT2

2.98e-051082539c7f3e25facfb54ef0be45044999bc36438bbea0
ToppCellE18.5-samps-Epithelial-Alveolar_epithelial-AT1|E18.5-samps / Age Group, Lineage, Cell class and subclass

FCGBP IGFBP6 MMP13

5.17e-05130253eb16a8f8f62add5fdd29c78d4608b6d1a06767f1
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Inner_Medullary_Collecting_Duct_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

GPT2 LRP1B ABTB2

7.01e-051442535665dd2839b6c8ddbf5ddb2d22e1ee6073f74c3b
ToppCellsaliva-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c02-AQP3|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

DGKB IGFBP6 QSOX2

7.31e-05146253159dd157a74f3c27dc1a1dcbbf0ed8f9462cac9e
ToppCellsaliva-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

TGFBR3 ABLIM1 MMP13

8.72e-051552537aba8ef53c9170ad8ed955c904c8991097ab1e32
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L2/3_IT-L2/3_IT_VISp_Agmat|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

DGKB IGFBP6 ADAMTSL2

8.89e-0515625309e0702400570089d9012dcf94dfb4827c97e49d
ToppCellfacs-Brain_Myeloid-Striatum_-18m-Myeloid-macrophage|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFP IGFBP6 HP

9.06e-051572539d4308312301cb922f156a7b6aededc9e1c62807
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-myeloid-myeloid_macrophage-microglial_cell|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

NCKAP5 FCGBP ADAMTSL2

9.41e-0515925331ec8222c766cb614e1cf27f74ee9d99489eca5c
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L2/3_IT|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

DGKB IGFBP6 ADAMTSL2

9.76e-05161253e3327c296d48e821004e61a573abb75624a6f040
ToppCellfacs-Liver-Non-hepatocytes-24m-Lymphocytic-T_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABLIM1 LRP1B VWDE

9.94e-0516225315d5d31a75e26bcd41919a00300c68e9f00f0002
ToppCellfacs-MAT-Fat-3m-Myeloid-myeloid_cell|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFP MMP13 HP

1.01e-041632535fc836444bc156c8248abee001b0ecbe43f980c9
ToppCellfacs-Brain_Myeloid-Hippocampus-24m-Myeloid-macrophage|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TGFBR3 CFP HP

1.05e-04165253ab6ed7e30096c418e7be2d5eec33feeddd1387d9
ToppCellChildren_(3_yrs)-Epithelial-lung_neuroendocrine_cell_(PNEC)-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

DGKB GPT2 VWDE

1.09e-04167253c87ebfa8c3284ad33579190e148c95bcaf670d17
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Astrocytoma-9|TCGA-Brain / Sample_Type by Project: Shred V9

TGFBR3 ABLIM1 GPT2

1.09e-04167253013971700e80b71e4b8c79b8fff0d8beeac295c3
ToppCell3'_v3-Lung-Myeloid_Mac-Intestinal_macrophages|Lung / Manually curated celltypes from each tissue

NCKAP5 FCGBP MMP13

1.13e-04169253241644823e6f949aaf4c671d4579721d7ef6b0e5
ToppCelldroplet-Heart-HEART_(LV+RV_ONLY)-30m-Hematologic-fibroblast|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NCKAP5 GPT2 HP

1.13e-0416925315a9183c838cc6384d7f5dfeae3d30602964c9b3
ToppCellRA-01._Fibroblast_I|RA / Chamber and Cluster_Paper

IGFBP6 ABTB2 ADAMTSL2

1.13e-041692536373562ab3b1765060212a6a53d6543e7e942e80
ToppCelldroplet-Fat-Scat|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFP IGFBP6 HP

1.15e-04170253de722bea7527d6ad11b69f8e9589638f52854beb
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DGKB NCKAP5 GPT2

1.17e-04171253f5014e3c387fe3118944af392abe10d6b9b0abab
ToppCell3'-Airway_Nasal_SMG-Epithelial-Epithelial_transtional-secretory-SMG_mucus_secreting_cell-SMG_mucous-SMG_mucous_L.0.6.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ABLIM1 FCGBP GPT2

1.23e-04174253b1b54e4e23df8cfc04bf298d5c53de203a38b267
ToppCellFetal_29-31_weeks-Epithelial-lung_goblet_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

FCGBP GPT2 VWDE

1.29e-04177253a4c001a8e44142babf9f24dfe6f7b73a70b11b16
ToppCellwk_08-11-Epithelial-PNS-FGFBP2+_Neural_progenitor|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

DGKB HMX2 VWDE

1.29e-0417725315a5c96ea840376e54933ebe7a8334a11d9ce411
ToppCellmetastatic_Brain-Fibroblasts-Undetermined|metastatic_Brain / Location, Cell class and cell subclass

ADAMTS12 TGFBR3 IGFBP6

1.29e-0417725354f39be5d90363cfd44dea1a96ae06d3143aa795
ToppCellFetal_29-31_weeks-Epithelial-lung_goblet_cell-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

FCGBP GPT2 VWDE

1.29e-04177253363e07b0f347f3716d530a28ead854b98e27d37c
ToppCellLPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ADAMTS12 TGFBR3 IGFBP6

1.34e-0417925302c90d8306016365ed811f0c63cfb3ac7b85464c
ToppCellRA-11._Adipocyte|RA / Chamber and Cluster_Paper

ADAMTS12 GPT2 LRP1B

1.36e-04180253d48a3d27357f7d184132a6805950f93080146b59
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

DGKB NCKAP5 GPT2

1.36e-041802531363b3254470f6ff98630d1df83a1bdbacc137e0
ToppCellRA-01._Fibroblast_I|World / Chamber and Cluster_Paper

IGFBP6 ABTB2 ADAMTSL2

1.38e-041812532b6ddeb53a79a658e2ba78527ff48c155b20daa6
ToppCellfacs-Spleen-nan-3m-Lymphocytic-Cd3e_T_cell|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TGFBR3 ABLIM1 ABTB2

1.38e-04181253be7c7db6b99603759593e6f79cdcaa4bbf234cb7
ToppCellClub-club-8|World / Class top

FCGBP IGFBP6 HP

1.40e-041822538111d917e588008d947021460ddf8f1e7ae1337a
ToppCellLA-11._Adipocyte|World / Chamber and Cluster_Paper

ADAMTS12 GPT2 LRP1B

1.43e-04183253b177be283e1553fb1f69a346f1ba79ad00297fa2
ToppCellLA-11._Adipocyte|LA / Chamber and Cluster_Paper

ADAMTS12 GPT2 LRP1B

1.43e-041832533f9011976782fa8aa95cdd6f00f07a91094d411b
ToppCellfacs-Spleen-nan-3m-Lymphocytic-CD4-positive,_alpha-beta_T_cell|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TGFBR3 ABLIM1 ABTB2

1.45e-04184253c37c623c4a5ff1628486d8a6461fa355ad5c264c
ToppCellAdult-Mesenchymal-matrix_fibroblast_2_cell-D122|Adult / Lineage, Cell type, age group and donor

TGFBR3 IGFBP6 ADAMTSL2

1.45e-041842532b7e6f91e11c228f0521e099886867d9e998e78d
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

DGKB ABLIM1 NCKAP5

1.50e-04186253b1edc341d6684b347dc9e21b34f62f51d095d735
ToppCellLA-01._Fibroblast_I|World / Chamber and Cluster_Paper

TGFBR3 IGFBP6 ABTB2

1.52e-041872534ea486991f66c29728d127171a07b81404ec0b78
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

DGKB LRP1B ABTB2

1.52e-04187253f124d2c699b717b7c02a1a70493f515b83dc2f4c
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Degenerative_Proximal_Tubule_Epithelial_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ABLIM1 NCKAP5 GPT2

1.52e-041872533ae3b8de1a195d4d5057cf3c64fcdb5f48681ce5
ToppCellControl-Fibroblasts-Adventitial_FB|Control / group, cell type (main and fine annotations)

TGFBR3 IGFBP6 ABTB2

1.54e-04188253706a26c372add839d947749f0521a0e1f5c9b0ec
ToppCellfacs-Pancreas-Exocrine-3m-Epithelial-pancreatic_ductal_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

WFDC3 GPT2 ABTB2

1.54e-04188253842982de2197770f999a70083ed9fca40ac22d79
ToppCellfacs-Pancreas-Exocrine-3m-Epithelial-pancreatic_ductal_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

WFDC3 GPT2 ABTB2

1.54e-04188253a0815eaf68eedd6e5ec4af520df80a6ab4eb0864
ToppCellRA-11._Adipocyte|World / Chamber and Cluster_Paper

ADAMTS12 GPT2 LRP1B

1.54e-041882534dac9d636e5cad4cda540b93d4bfed6b5732c880
ToppCell10x3'2.3-week_14-16-Mesenchymal_fibro-stroma-endosteal_fibroblast|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

DGKB TGFBR3 IGFBP6

1.54e-041882530e2d1b21f0a7ee306e7dae16fc8c19d16a467883
ToppCellIPF-Endothelial-VE_Capillary_A|World / Disease state, Lineage and Cell class

TGFBR3 ABLIM1 NCKAP5

1.57e-04189253ea3aa3ef38f1d405bb527ae383cd12c551a3dd6f
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

DGKB LRP1B ABTB2

1.57e-04189253e32172ad09e93f6ac6ea2b92145b2b73003f7970
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_myocytic-mes_ASM_(13)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

LRP1B ABTB2 ADAMTSL2

1.59e-04190253938d1f66094b1c94606e0d40213a39e5112f3322
ToppCellfacs-Mammary_Gland-Mammary_Gland-21m-Epithelial-luminal_progenitor_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

WFDC3 FCGBP HP

1.59e-041902530bad41d19dc515e6bc61e699f4d56664cf2e72fd
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro1_(4)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

TGFBR3 NCKAP5 LRP1B

1.59e-041902537986586b7c82e91c71102cc8c4d7a689ae63ab4d
ToppCellIPF-Endothelial-VE_Capillary_A|IPF / Disease state, Lineage and Cell class

TGFBR3 ABLIM1 NCKAP5

1.59e-04190253b4e35cbfe4d43d2cd51f29c3085e4d9b1012e6f0
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro1_(4)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

ADAMTS12 NCKAP5 LRP1B

1.62e-04191253fa380a8752de158974b2ae5e741573439719cc0d
ToppCellPND01-03-samps-Mesenchymal-Matrix_fibroblast-MatrixFB-A|PND01-03-samps / Age Group, Lineage, Cell class and subclass

ADAMTS12 DGKB ADAMTSL2

1.62e-04191253e7c605b56934d1383237c1f946dbccef25d91368
ToppCellfacs-Heart-LV-3m-Mesenchymal-fibroblast_of_cardiac_tissue|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TGFBR3 IGFBP6 ADAMTSL2

1.64e-04192253671d4e1eee5aba03c43dbc98f4b51ce42b3df5d5
ToppCellfacs-Heart-LV-3m-Mesenchymal-fibroblast_of_cardiac_tissue|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TGFBR3 IGFBP6 ADAMTSL2

1.64e-04192253840a34c1b82d218be999ab5e1bcafd6370d7a4b1
ToppCell3'-Adult-LargeIntestine-Mesenchymal-fibroblastic-mLN_Stroma_(FMO2+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TGFBR3 IGFBP6 LRP1B

1.64e-0419225311867f30f0b420c18cb0b34d3990237aa737a0e8
ToppCellfacs-Mammary_Gland-Mammary_Gland-18m-Epithelial-luminal_epithelial_cell_of_mammary_gland|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

WFDC3 FCGBP HP

1.67e-041932531526f51b589a7dc7a28f35f0e788dc38d338d2bc
ToppCellParenchymal-NucSeq-Stromal-Fibroblastic-Fibro_perichondrial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

IGFBP6 LRP1B ABTB2

1.67e-04193253e5016959f24370579a8770787e96869f264cf7b3
ToppCellControl-Stromal-Myofibroblast|Stromal / Disease state, Lineage and Cell class

ADAMTS12 NCKAP5 ADAMTSL2

1.67e-041932535896242f713ae5fd1a4ebb63827f15d7279dced2
ToppCellControl-CD8+_T_naive|Control / Disease condition and Cell class

ABLIM1 ZNF609 FCGBP

1.67e-04193253627d345baf1940218c61907305705298e473dbab
ToppCelldroplet-Mammary_Gland-nan-21m-Epithelial-luminal_epithelial_cell_of_mammary_gland|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

WFDC3 FCGBP HP

1.67e-0419325322ebc3f586eb0aabc5785e468c88d7416c624ff4
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-4M-Mesenchymal|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.

ADAMTS12 TGFBR3 IGFBP6

1.69e-041942534bafe26573cb2ff966f4a688c5769da598eea415
ToppCellChildren_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

ADAMTS12 TGFBR3 ADAMTSL2

1.69e-04194253e93de9428c986b8943fc169258847c650cfab0e5
ToppCellPBMC-Control-Myeloid-cDC-cDC-cDC_4|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CFP NCKAP5 LRP1B

1.69e-041942535c60670ec24470225fabaa6071fdb4ef6e579840
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ABLIM1 LRP1B ABTB2

1.69e-0419425346070fbb0ee0eb9e1801c43b73a15707471056dc
ToppCellPBMC-Control-Myeloid-cDC-cDC-cDC_4|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

CFP NCKAP5 LRP1B

1.69e-041942536af2971d83f5ad6aed16d0ceb8bfc52f3947bc10
ToppCelldroplet-Mammary_Gland-nan-21m-Epithelial-luminal_progenitor_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

WFDC3 FCGBP HP

1.69e-041942530ef63abcfd057079a9a6f8b27404ff521d44845d
ToppCellPND01-03-samps-Mesenchymal|PND01-03-samps / Age Group, Lineage, Cell class and subclass

DGKB TGFBR3 ADAMTSL2

1.69e-041942534f9bd0ded0dde1df885850714f29e73e992539a5
ToppCellLV-02._Fibroblast_II|LV / Chamber and Cluster_Paper

TGFBR3 IGFBP6 ABTB2

1.69e-04194253014d2feb5db2a6a35ef759761a41e466e108c3c1
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ABLIM1 LRP1B ABTB2

1.69e-04194253abacb6a8d7a9003f2f6c2be0305507f1c1c50347
ToppCellLA-02._Fibroblast_II|LA / Chamber and Cluster_Paper

TGFBR3 IGFBP6 ABTB2

1.69e-04194253234d1494c114cce77c619708bbcd8d5ce805f19b
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-4M-Mesenchymal-choroid_plexus/mesenchymal-like_cells|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.

ADAMTS12 TGFBR3 IGFBP6

1.69e-041942538ac0b63c7a89e5ff78bbdd8dd1960aa2422a85f7
ToppCell3'_v3-blood-Lymphocytic_T_CD8-Tnaive/CM_CD8|blood / Manually curated celltypes from each tissue

ABLIM1 ZNF609 FCGBP

1.69e-04194253390bf41cccfd586725a2fe653a299a78e261ec9b
ToppCellproximal-Epithelial-Serous|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

FCGBP GPT2 ABTB2

1.72e-04195253cb62f04f0e45bfb36eed2e7a3fc54d6d390b2ed1
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ABLIM1 LRP1B ABTB2

1.72e-041952536477e6e7be5bd8eb99119a12ae16334ccddecd43
ToppCellproximal-Epithelial-Serous-3|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

FCGBP GPT2 ABTB2

1.72e-0419525306b73abc1f32543f2a51db52dc6424a2a398fe0f
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTS12 IGFBP6 ADAMTSL2

1.72e-041952533c3703f092b6fc1b7333426fb5e2823bfb74bb57
ToppCellNasal_Brush|World / Tissue, Lineage and Cell class of Lung Cells from 10X

ABLIM1 FCGBP GPT2

1.72e-041952537509b980b6b293df02bec619ef5b83a6c7b49c03
ToppCellfacs-Mammary_Gland-Mammary_Gland-21m-Epithelial-luminal_epithelial_cell_of_mammary_gland|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

WFDC3 FCGBP HP

1.72e-0419525325703e3c2e0512ef12e7aa389fad3968c3f13905
ToppCellRA-02._Fibroblast_II|RA / Chamber and Cluster_Paper

TGFBR3 IGFBP6 ABTB2

1.72e-041952536a02ebbeb3199447ddce64d92d8809436e040eba
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTS12 TGFBR3 ADAMTSL2

1.72e-04195253803f714d91f2d97ecbee8c15a5139fd9310f66c7
ToppCellBronchial-NucSeq-Stromal-Fibroblastic-Fibro_myofibroblast|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ADAMTS12 TGFBR3 ABTB2

1.72e-04195253f5e91ce20a7ce528dc4c1a968c7bf096bf45c528
ToppCellproximal-3-Epithelial-Serous|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

FCGBP GPT2 ABTB2

1.72e-0419525324a6a566143b04e37ad002e4c55037a0460ac2ef
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTS12 TGFBR3 ADAMTSL2

1.72e-041952534f70157d42a16ff0259bc24a62803c4df4285c44
ToppCellLA-02._Fibroblast_II|World / Chamber and Cluster_Paper

TGFBR3 IGFBP6 ABTB2

1.72e-04195253a78b605b49acd8c9d68716266ca269dafcd910b9
ToppCell10x3'2.3-week_14-16-Mesenchymal_fibro|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

DGKB TGFBR3 IGFBP6

1.74e-04196253ee45e4de9d706ec87094e87f47d3e514539b8092
ToppCellfacs-Trachea-24m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l20-25|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TGFBR3 ABLIM1 IGFBP6

1.74e-04196253ed6047b48b6a96baa6a90c7af784e7c34b32824d
ToppCellCOPD-Stromal-Fibroblast|Stromal / Disease state, Lineage and Cell class

TGFBR3 ABLIM1 IGFBP6

1.74e-041962534930eeb303d174c28fd91021723e26fdf1af9170
ToppCell10x3'2.3-week_14-16-Mesenchymal_fibro-stroma|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

DGKB TGFBR3 IGFBP6

1.74e-04196253fa4a85a3cd52df0da5dfedc0e584e9df8c61ce89
ToppCellRA-02._Fibroblast_II|World / Chamber and Cluster_Paper

IGFBP6 ABTB2 ADAMTSL2

1.74e-04196253e8cbda03837f1f26470a9d93aa7fdaa04e08e38a
ToppCellCOVID-19-lung-Capillary_Aerocytes|lung / Disease (COVID-19 only), tissue and cell type

TGFBR3 ABLIM1 LRP1B

1.74e-041962534ac4073380d939a73cec7413e9f3f5ef616d2924
ToppCell10x3'2.3-week_17-19-Mesenchymal_adipo-stroma|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

NCKAP5 IGFBP6 MMP13

1.77e-04197253b9745e382baa2725dfcae060701fb53f6c8a31fa
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Myeloid-Dendritic|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

CFP NCKAP5 LRP1B

1.77e-0419725389fe4885efc8db142c0dc0506840ae8aceba9ef9
ToppCellHealthy/Control-cDC|Healthy/Control / Disease group and Cell class

CFP NCKAP5 LRP1B

1.77e-04197253926423aae9fcf654f84b0f7621103a6a22d3aced
ToppCell10x3'2.3-week_17-19-Mesenchymal_adipo|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

NCKAP5 IGFBP6 MMP13

1.77e-041972535afddde4e2b5cd55abe11e9b9efae02dbdc3da3a
DrugMemantine Hydrochloride [41100-52-1]; Down 200; 18.6uM; MCF7; HT_HG-U133A

ZNF609 ZNF227 IGFBP6 ABTB2

5.62e-051942547354_DN
DrugUrapidil hydrochloride [64887-14-5]; Up 200; 9.4uM; HL60; HT_HG-U133A

ZNF609 BTD ABTB2 FAM3A

5.73e-051952543078_UP
DrugAsiaticoside [16830-15-2]; Down 200; 4.2uM; MCF7; HT_HG-U133A

ABLIM1 BTD FAM3A NFX1

5.73e-051952547004_DN
DrugTamoxifen citrate [54965-24-1]; Down 200; 7uM; PC3; HT_HG-U133A

ABLIM1 ZNF609 BTD ABTB2

5.73e-051952542050_DN
DrugDobutamine hydrochloride [49745-95-1]; Down 200; 11.8uM; MCF7; HT_HG-U133A

TGFBR3 ZNF609 IGFBP6 NFX1

5.85e-051962545386_DN
DrugTubocurarine chloride pentahydrate (+) [6989-98-6]; Down 200; 5.2uM; MCF7; HT_HG-U133A

TGFBR3 ZNF609 IGFBP6 BTD

5.96e-051972545449_DN
DrugEtodolac [41340-25-4]; Up 200; 14uM; PC3; HT_HG-U133A

ZNF609 ZNF227 FAM3A NFX1

5.96e-051972542091_UP
DrugN-Acetyl-DL-homocysteine Thiolactone [1195-16-0]; Down 200; 25.2uM; HL60; HT_HG-U133A

TGFBR3 ZNF609 BTD FAM3A

5.96e-051972542176_DN
DrugRifampicin [13292-46-1]; Up 200; 4.8uM; HL60; HT_HG-U133A

ABLIM1 ZNF609 BTD ABTB2

6.08e-051982542487_UP
DrugNomifensine maleate [32795-47-4]; Up 200; 11.2uM; HL60; HG-U133A

ADAMTS12 ZNF609 ZNF330 NFX1

6.08e-051982541378_UP
DrugDydrogesterone [152-62-5]; Up 200; 12.8uM; MCF7; HT_HG-U133A

ZNF609 IGFBP6 MMP13 NFX1

6.08e-051982544836_UP
DrugArcaine sulfate [14923-17-2]; Up 200; 14.8uM; HL60; HT_HG-U133A

TGFBR3 CFP BTD ABTB2

6.08e-051982543010_UP
DrugPiperacetazine [3819-00-9]; Down 200; 9.8uM; MCF7; HT_HG-U133A

TGFBR3 ZNF609 IGFBP6 BTD

6.20e-051992543574_DN
DrugAmprolium hydrochloride [137-88-2]; Up 200; 12.6uM; HL60; HG-U133A

ZNF609 IGFBP6 ABTB2 FAM3A

6.20e-051992541979_UP
Diseasesevere acute respiratory syndrome, COVID-19

ADAMTS12 DGKB TGFBR3 ABLIM1 LRP1B ABTB2

1.62e-06447256EFO_0000694, MONDO_0100096
Diseasenon-alcoholic fatty liver disease (is_marker_for)

GPT2 HP

2.39e-0427252DOID:0080208 (is_marker_for)
Diseasearteriosclerosis (is_implicated_in)

MMP13 HP

3.16e-0431252DOID:2349 (is_implicated_in)
Diseaseresponse to radiation, prostate carcinoma, erectile dysfunction

LRP1B NFX1

4.51e-0437252EFO_0001663, EFO_0004234, GO_0009314
Diseasemethylcobalamin deficiency type cblE

ABLIM1 VWDE

1.79e-0374252MONDO_0009354
Diseaseinformation processing speed

NCKAP5 LRP1B

2.36e-0385252EFO_0004363
Diseasecongestive heart failure (biomarker_via_orthology)

MMP13 HP

3.70e-03107252DOID:6000 (biomarker_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
KDHCDPKVLCIINPG

GPT2

256

Q8TD30
PSEKPVIHCHKCGEP

ABLIM1

91

O14639
QCLCDHKPRPPEFKK

ADAMTS12

1511

P58397
PTPDLCPACHEEIKG

QSOX2

531

Q6ZRP7
CPDHSDEAPLNPKCK

LRP1B

2871

Q9NZR2
CEADDGCPKPPEIAH

HP

86

P00738
EDPNPKHPKTPDKCD

MMP13

271

P45452
KAPACFCPDQHGPKE

HMX2

61

A2RU54
CHKGECLVDEPCKQP

NFX1

841

Q12986
TKPLAIHPCGDKNCP

ADAMTSL2

781

Q86TH1
EKRPCLHVPACKDPE

CFP

451

P27918
KYKCGLPQPCPEEHL

FAM3A

56

P98173
CHKLVDPQGPLKDCI

FCGBP

3876

Q9Y6R7
ASHLKPECDCGPLKD

DGKB

351

Q9Y6T7
KEPCHSSDPRCPKDG

BTD

176

P43251
DEPCKKCGLPNHPEL

RSF1

891

Q96T23
PNCAPGLQCHPPKDD

IGFBP6

76

P24592
PCKTADLGSPCKEPH

NCKAP5

451

O14513
PGLDCEPRQLKPEHC

ABTB2

456

Q8N961
EHAKEGECPPHKNPC

WFDC3

26

Q8IUB2
GECPPHKNPCKELCQ

WFDC3

31

Q8IUB2
DPDCKNHGKCIKPNI

VWDE

1331

Q8N2E2
PCHLPQESKTKTPDC

SPEM3

186

A0A1B0GUW6
SPVLIDCPHPNCNKK

ZNF609

491

O15014
QKLPLGEKPHPCGEC

ZNF227

241

Q86WZ6
EKGKQPPCPKCGHET

ZNF330

206

Q9Y3S2
PPCPKCGHETQETKD

ZNF330

211

Q9Y3S2
HPQKLPKCVPPDEAC

TGFBR3

716

Q03167