Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcessregulation of plasma membrane bounded cell projection organization

BMP7 TBC1D10B KREMEN1 PTPRG WASHC5 USP6NL PLEKHM1 WDR44 EHD1 PLCE1

1.23e-068463610GO:0120035
GeneOntologyBiologicalProcessregulation of cell projection organization

BMP7 TBC1D10B KREMEN1 PTPRG WASHC5 USP6NL PLEKHM1 WDR44 EHD1 PLCE1

1.47e-068633610GO:0031344
GeneOntologyBiologicalProcessregulation of plasma membrane bounded cell projection assembly

TBC1D10B USP6NL PLEKHM1 WDR44 PLCE1

6.71e-05248365GO:0120032
GeneOntologyBiologicalProcessregulation of cell projection assembly

TBC1D10B USP6NL PLEKHM1 WDR44 PLCE1

7.10e-05251365GO:0060491
GeneOntologyBiologicalProcessplasma membrane bounded cell projection assembly

TBC1D10B USP6NL PLEKHM1 WDR44 EHD1 PLCE1 EHD3

1.36e-04670367GO:0120031
GeneOntologyBiologicalProcesscell projection assembly

TBC1D10B USP6NL PLEKHM1 WDR44 EHD1 PLCE1 EHD3

1.56e-04685367GO:0030031
GeneOntologyCellularComponentciliary pocket membrane

EHD1 EHD3

8.16e-063352GO:0020018
GeneOntologyCellularComponentciliary pocket

EHD1 EHD3

8.16e-063352GO:0020016
GeneOntologyCellularComponentendosome membrane

ATG9B WASHC5 PLEKHM1 WDR44 EHD1 EHD3

4.43e-04602356GO:0010008
GeneOntologyCellularComponentrecycling endosome membrane

ATG9B EHD1 EHD3

8.65e-04112353GO:0055038
DomainEHD1/EHD3

EHD1 EHD3

3.61e-062362IPR029951
DomainEHD_N

EHD1 EHD3

3.60e-055362PF16880
DomainEHD_N

EHD1 EHD3

3.60e-055362IPR031692
DomainEF-hand_4

EHD1 EHD3

1.61e-0410362PF12763
DomainEH

EHD1 EHD3

1.97e-0411362PS50031
DomainEH

EHD1 EHD3

1.97e-0411362SM00027
DomainEH_dom

EHD1 EHD3

1.97e-0411362IPR000261
DomainG_DYNAMIN_dom

EHD1 EHD3

3.24e-0414362IPR030381
DomainG_DYNAMIN_2

EHD1 EHD3

3.24e-0414362PS51718
DomainDynamin_SF

EHD1 EHD3

3.73e-0415362IPR022812
DomainDynamin_GTPase

EHD1 EHD3

3.73e-0415362IPR001401
DomainDynamin_N

EHD1 EHD3

3.73e-0415362PF00350
Domain-

RCN1 EHD1 PLCE1 EHD3

1.54e-032613641.10.238.10
DomainEF-hand-dom_pair

RCN1 EHD1 PLCE1 EHD3

2.18e-03287364IPR011992
DomainEF-hand_1

RCN1 EHD1 EHD3

3.10e-03152363PF00036
DomainTBC

TBC1D10B USP6NL

4.01e-0349362SM00164
DomainEF_Hand_1_Ca_BS

RCN1 EHD1 EHD3

4.60e-03175363IPR018247
DomainRabGAP-TBC

TBC1D10B USP6NL

4.68e-0353362PF00566
DomainTBC_RABGAP

TBC1D10B USP6NL

5.03e-0355362PS50086
DomainRab-GTPase-TBC_dom

TBC1D10B USP6NL

5.03e-0355362IPR000195
Domain-

ACAD10 CTDNEP1

6.76e-03643623.40.50.1000
DomainEF_HAND_1

RCN1 EHD1 EHD3

7.03e-03204363PS00018
DomainEF_HAND_2

RCN1 EHD1 EHD3

9.87e-03231363PS50222
DomainEF_hand_dom

RCN1 EHD1 EHD3

9.99e-03232363IPR002048
DomainHAD-like_dom

ACAD10 CTDNEP1

1.01e-0279362IPR023214
Pubmed

Cooperative polarization of MCAM/CD146 and ERM family proteins in melanoma.

TBC1D10B PTPRG SLC20A2 USP6NL WDR44 EHD1 EHD3

1.06e-0737736738117590
Pubmed

SUMOylation of EHD3 Modulates Tubulation of the Endocytic Recycling Compartment.

EHD1 EHD3

1.04e-06236226226295
Pubmed

EHD3: a protein that resides in recycling tubular and vesicular membrane structures and interacts with EHD1.

EHD1 EHD3

3.12e-06336212121420
Pubmed

Differential roles of C-terminal Eps15 homology domain proteins as vesiculators and tubulators of recycling endosomes.

EHD1 EHD3

3.12e-06336224019528
Pubmed

Early steps in primary cilium assembly require EHD1/EHD3-dependent ciliary vesicle formation.

EHD1 EHD3

3.12e-06336225686250
Pubmed

Shared as well as distinct roles of EHD proteins revealed by biochemical and functional comparisons in mammalian cells and C. elegans.

EHD1 EHD3

6.24e-06436217233914
Pubmed

Interactions between EHD proteins and Rab11-FIP2: a role for EHD3 in early endosomal transport.

EHD1 EHD3

6.24e-06436216251358
Pubmed

EHD2, EHD3, and EHD4 encode novel members of a highly conserved family of EH domain-containing proteins.

EHD1 EHD3

6.24e-06436210673336
Pubmed

C-terminal EH-domain-containing proteins: consensus for a role in endocytic trafficking, EH?

EHD1 EHD3

6.24e-06436216155252
Pubmed

EHD3 Protein Is Required for Tubular Recycling Endosome Stabilization, and an Asparagine-Glutamic Acid Residue Pair within Its Eps15 Homology (EH) Domain Dictates Its Selective Binding to NPF Peptides.

EHD1 EHD3

6.24e-06436227189942
Pubmed

Rabenosyn-5 and EHD1 interact and sequentially regulate protein recycling to the plasma membrane.

EHD1 EHD3

6.24e-06436215020713
Pubmed

Role of the EHD Family of Endocytic Recycling Regulators for TCR Recycling and T Cell Function.

EHD1 EHD3

6.24e-06436229212907
Pubmed

EH domain proteins regulate cardiac membrane protein targeting.

EHD1 EHD3

1.04e-05536220489164
Pubmed

MICAL-L1 links EHD1 to tubular recycling endosomes and regulates receptor recycling.

EHD1 EHD3

1.56e-05636219864458
Pubmed

Myosin Vb interacts with Rab8a on a tubular network containing EHD1 and EHD3.

EHD1 EHD3

2.91e-05836217507647
Pubmed

Association of insulin-like growth factor 1 receptor with EHD1 and SNAP29.

EHD1 EHD3

3.73e-05936211423532
Pubmed

Combinatorial CRISPR screen identifies fitness effects of gene paralogues.

USP35 IDH3G UAP1L1 CNOT8

4.08e-0518636433637726
Pubmed

The endocytic recycling regulatory protein EHD1 Is required for ocular lens development.

EHD1 EHD3

5.70e-051136226455409
Pubmed

Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations.

ACAD10 PLCE1

5.70e-051136221642993
Pubmed

Comprehensive Expression of Wnt Signaling Pathway Genes during Development and Maturation of the Mouse Cochlea.

KREMEN1 MYO7A

6.83e-051236226859490
Pubmed

Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

WASHC5 WDR44 EHD1 EHD3

1.56e-0426336412665801
Pubmed

Specific Rab GTPase-activating proteins define the Shiga toxin and epidermal growth factor uptake pathways.

TBC1D10B USP6NL

2.16e-042136217562788
Pubmed

Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex.

RCN1 IDH3G WASHC5 ITIH2

2.70e-0430436432235678
Pubmed

The phosphatase Dullard negatively regulates BMP signalling and is essential for nephron maintenance after birth.

BMP7 CTDNEP1

2.83e-042436223360989
Pubmed

The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.

TBC1D10B PTPRG SLC20A2 USP6NL EHD1

2.86e-0456936530639242
Pubmed

Endocytic recycling protein EHD1 regulates primary cilia morphogenesis and SHH signaling during neural tube development.

EHD1 EHD3

3.87e-042836226884322
Pubmed

RNA microarray analysis in prenatal mouse cochlea reveals novel IGF-I target genes: implication of MEF2 and FOXM1 transcription factors.

DNAJB7 MYO7A

5.07e-043236220111592
Pubmed

Human variation in alcohol response is influenced by variation in neuronal signaling genes.

PTPRG MYO7A PLCE1

7.40e-0417136320201926
Pubmed

The LIFEdb database in 2006.

IDH3G LGALSL USP6NL CNOT8 WDR44

8.31e-0472036516381901
Pubmed

From ORFeome to biology: a functional genomics pipeline.

IDH3G LGALSL USP6NL CNOT8 WDR44

8.41e-0472236515489336
Pubmed

Functional dissection of Rab GTPases involved in primary cilium formation.

TBC1D10B USP6NL

9.16e-044336217646400
Pubmed

Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity.

TBC1D10B USP6NL

9.16e-044336219077034
InteractionSCP2D1 interactions

EHD1 EHD3

9.30e-063362int:SCP2D1
InteractionLAMP1 interactions

TBC1D10B PTPRG DCTN5 SLC20A2 USP6NL PLEKHM1 EPAS1 EHD1

1.43e-05644368int:LAMP1
InteractionMCAM interactions

TBC1D10B PTPRG SLC20A2 USP6NL WDR44 EHD1 EHD3

1.62e-05468367int:MCAM
CytobandEnsembl 112 genes in cytogenetic band chr10p14

USP6NL ITIH2

6.87e-0449362chr10p14
GeneFamilyEF-hand domain containing

RCN1 EHD1 EHD3

4.59e-03219283863
ToppCellfacs-Liver-Liver_non-hepato/SCs_st-18m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RCN1 MYO7A EPAS1 EHD3

1.67e-0519136488f91e57a1409bdeb91e9bf47510a6fb998a1bf5
ToppCellfacs-Liver-Liver_non-hepato/SCs_st-18m-Endothelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RCN1 MYO7A EPAS1 EHD3

1.67e-051913641924af7d8b0a0b892e480a9fd6d874941b0c0b5d
ToppCell3'-GW_trimst-2-SmallIntestine-Mesenchymal-fibroblastic-Stromal_2_(CH25H+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

BMP7 KREMEN1 PTPRG EHD3

1.92e-05198364447d7182edb2cd8a72ebd3c0d16bc6e4ddcaaa5c
Diseaseesophageal carcinoma

ACAD10 PLCE1

5.49e-0430342EFO_0002916
Diseasealopecia

BMP7 PLEKHM1 EHD3

2.67e-03241343MONDO_0004907
DiseaseHereditary Diffuse Gastric Cancer

BMP7 PTPRG PLCE1

4.62e-03293343C1708349
DiseaseStomach Neoplasms

BMP7 PTPRG PLCE1

4.80e-03297343C0038356
DiseaseMalignant neoplasm of stomach

BMP7 PTPRG PLCE1

4.93e-03300343C0024623
Diseaseuric acid measurement

CSTB ACAD10 SLC20A2 EPAS1

5.13e-03610344EFO_0004761
DiseaseSquamous cell carcinoma of esophagus

CSTB PLCE1

5.38e-0395342C0279626

Protein segments in the cluster

PeptideGeneStartEntry
HHEKETFLDPFVLRD

PTPRG

226

P23470
IFDFTHPCDHEEIRE

EPAS1

131

Q99814
EHHLSDREFVFKEPQ

ALKBH3

46

Q96Q83
DEDFVHLRVFQSLPH

CSTB

61

P04080
HGDFRLDNLVFHPEE

ACAD10

461

Q6JQN1
PIRHHPDFEVFVFDV

CTBS

51

Q01459
FVNLVEHDKEFFHPR

BMP7

136

P18075
ATREEFTAFLHPEEF

RCN1

186

Q15293
EHPRFRVFVDGHQLF

LGALSL

131

Q3ZCW2
LRFLHVPDTFEGHFD

ITIH2

221

P19823
DPEEAHVIRFLEFFH

HIPK4

66

Q8NE63
RHEFRFPEEEFDGHQ

IFNA7

56

P01567
EFFRHIHAPEERGEY

FBXO8

216

Q9NRD0
HIHFSFPLFDIRDSA

KREMEN1

251

Q96MU8
VFKEIFHERDPFSFH

DNAJB7

96

Q7Z6W7
VFRHACVPVDFEEVH

IDH3G

76

P51553
RPRALEIIDFFHHFT

ATG9B

646

Q674R7
AFFPLHIGDHVFIEE

DCTN5

81

Q9BTE1
DSRLPEEEHEFFHIL

CNOT8

171

Q9UFF9
EEEHEFFHILNLFFP

CNOT8

176

Q9UFF9
RFHEFHSPALEDADF

EHD1

41

Q9H4M9
EEKDAPEVHLLFHFL

SLC20A2

476

Q08357
HHDIIFPFEFDTTVR

PLEKHM1

1006

Q9Y4G2
HIEDVHSEPLFRKDF

TMC3

846

Q7Z5M5
FHVHFEDLVFLRFAV

PLCE1

1926

Q9P212
RFHEFHSPALEDADF

EHD3

41

Q9NZN3
FFVHKRPHVDFFLEV

CTDNEP1

106

O95476
DRFGFLHEEELPDHN

USP6NL

46

Q92738
RVAEAHVPNFIFDEF

WASHC5

1141

Q12768
PFHRDTFHFLREEKF

ZNF223

51

Q9UK11
HHPDVFAEFFSARRV

USP35

71

Q9P2H5
HIDFVTAIAFHPRDD

WDR44

646

Q5JSH3
PTAEFFREHNFFHLD

UAP1L1

176

Q3KQV9
DVIEKDLHRQFPFHE

TBC1D10B

401

Q4KMP7
RPFLLNRTEHFIHEF

TOPORS

341

Q9NS56
DPLSEERFHVELHFS

PPIP5K1

896

Q6PFW1
VPENDFFFDFVRHLT

MYO7A

1956

Q13402