| Category | Name | IntersectionWithQuery | PValue | GenesInTerm | GenesInQuery | GenesInTermInQuery | ID |
|---|---|---|---|---|---|---|---|
| GeneOntologyMolecularFunction | metal ion transmembrane transporter activity | KCNK5 KCNH6 KCNH7 PSEN1 PKD2L2 SLC24A4 P2RX4 CATSPER2 SLC24A1 KCNH2 SLC6A14 | 5.48e-12 | 465 | 26 | 11 | GO:0046873 |
| GeneOntologyMolecularFunction | monoatomic cation channel activity | KCNK5 KCNH6 KCNH7 PSEN1 PKD2L2 SLC24A4 P2RX4 CATSPER2 SLC24A1 KCNH2 | 8.17e-12 | 343 | 26 | 10 | GO:0005261 |
| GeneOntologyMolecularFunction | inorganic cation transmembrane transporter activity | KCNK5 KCNH6 KCNH7 PSEN1 PKD2L2 SLC24A4 P2RX4 CATSPER2 SLC24A1 KCNH2 SLC6A14 | 1.35e-10 | 627 | 26 | 11 | GO:0022890 |
| GeneOntologyMolecularFunction | monoatomic ion channel activity | KCNK5 KCNH6 KCNH7 PSEN1 PKD2L2 SLC24A4 P2RX4 CATSPER2 SLC24A1 KCNH2 | 1.43e-10 | 459 | 26 | 10 | GO:0005216 |
| GeneOntologyMolecularFunction | monoatomic cation transmembrane transporter activity | KCNK5 KCNH6 KCNH7 PSEN1 PKD2L2 SLC24A4 P2RX4 CATSPER2 SLC24A1 KCNH2 SLC6A14 | 2.48e-10 | 664 | 26 | 11 | GO:0008324 |
| GeneOntologyMolecularFunction | channel activity | KCNK5 KCNH6 KCNH7 PSEN1 PKD2L2 SLC24A4 P2RX4 CATSPER2 SLC24A1 KCNH2 | 5.28e-10 | 525 | 26 | 10 | GO:0015267 |
| GeneOntologyMolecularFunction | passive transmembrane transporter activity | KCNK5 KCNH6 KCNH7 PSEN1 PKD2L2 SLC24A4 P2RX4 CATSPER2 SLC24A1 KCNH2 | 5.37e-10 | 526 | 26 | 10 | GO:0022803 |
| GeneOntologyMolecularFunction | inorganic molecular entity transmembrane transporter activity | KCNK5 KCNH6 KCNH7 PSEN1 PKD2L2 SLC24A4 P2RX4 CATSPER2 SLC24A1 KCNH2 SLC6A14 | 1.01e-09 | 758 | 26 | 11 | GO:0015318 |
| GeneOntologyMolecularFunction | monoatomic ion transmembrane transporter activity | KCNK5 KCNH6 KCNH7 PSEN1 PKD2L2 SLC24A4 P2RX4 CATSPER2 SLC24A1 KCNH2 SLC6A14 | 1.62e-09 | 793 | 26 | 11 | GO:0015075 |
| GeneOntologyMolecularFunction | transmembrane transporter activity | KCNK5 KCNH6 KCNH7 PSEN1 PKD2L2 SLC24A4 P2RX4 CATSPER2 SLC24A1 SLC27A6 KCNH2 SLC6A14 | 7.65e-09 | 1180 | 26 | 12 | GO:0022857 |
| GeneOntologyMolecularFunction | calcium channel activity | 1.34e-08 | 129 | 26 | 6 | GO:0005262 | |
| GeneOntologyMolecularFunction | transporter activity | KCNK5 KCNH6 KCNH7 PSEN1 PKD2L2 SLC24A4 P2RX4 CATSPER2 SLC24A1 SLC27A6 KCNH2 SLC6A14 | 2.06e-08 | 1289 | 26 | 12 | GO:0005215 |
| GeneOntologyMolecularFunction | calcium ion transmembrane transporter activity | 3.44e-08 | 151 | 26 | 6 | GO:0015085 | |
| GeneOntologyMolecularFunction | potassium ion transmembrane transporter activity | 6.27e-08 | 167 | 26 | 6 | GO:0015079 | |
| GeneOntologyMolecularFunction | ligand-gated monoatomic cation channel activity | 9.21e-07 | 140 | 26 | 5 | GO:0099094 | |
| GeneOntologyMolecularFunction | voltage-gated monoatomic cation channel activity | 1.38e-06 | 152 | 26 | 5 | GO:0022843 | |
| GeneOntologyMolecularFunction | voltage-gated monoatomic ion channel activity | 3.35e-06 | 182 | 26 | 5 | GO:0005244 | |
| GeneOntologyMolecularFunction | voltage-gated channel activity | 3.54e-06 | 184 | 26 | 5 | GO:0022832 | |
| GeneOntologyMolecularFunction | gated channel activity | 3.63e-06 | 334 | 26 | 6 | GO:0022836 | |
| GeneOntologyMolecularFunction | ligand-gated monoatomic ion channel activity | 4.47e-06 | 193 | 26 | 5 | GO:0015276 | |
| GeneOntologyMolecularFunction | ligand-gated channel activity | 4.94e-06 | 197 | 26 | 5 | GO:0022834 | |
| GeneOntologyMolecularFunction | inward rectifier potassium channel activity | 6.28e-06 | 28 | 26 | 3 | GO:0005242 | |
| GeneOntologyMolecularFunction | voltage-gated potassium channel activity | 8.80e-06 | 102 | 26 | 4 | GO:0005249 | |
| GeneOntologyMolecularFunction | calcium, potassium:sodium antiporter activity | 1.63e-05 | 5 | 26 | 2 | GO:0008273 | |
| GeneOntologyMolecularFunction | potassium channel activity | 2.16e-05 | 128 | 26 | 4 | GO:0005267 | |
| GeneOntologyMolecularFunction | aspartic endopeptidase activity, intramembrane cleaving | 4.54e-05 | 8 | 26 | 2 | GO:0042500 | |
| GeneOntologyMolecularFunction | calcium:sodium antiporter activity | 7.29e-05 | 10 | 26 | 2 | GO:0005432 | |
| GeneOntologyMolecularFunction | calcium:monoatomic cation antiporter activity | 1.26e-04 | 13 | 26 | 2 | GO:0015368 | |
| GeneOntologyMolecularFunction | solute:potassium antiporter activity | 2.75e-04 | 19 | 26 | 2 | GO:0022821 | |
| GeneOntologyMolecularFunction | symporter activity | 9.52e-04 | 150 | 26 | 3 | GO:0015293 | |
| GeneOntologyMolecularFunction | aspartic-type endopeptidase activity | 1.06e-03 | 37 | 26 | 2 | GO:0004190 | |
| GeneOntologyMolecularFunction | aspartic-type peptidase activity | 1.11e-03 | 38 | 26 | 2 | GO:0070001 | |
| GeneOntologyMolecularFunction | sodium ion transmembrane transporter activity | 1.39e-03 | 171 | 26 | 3 | GO:0015081 | |
| GeneOntologyMolecularFunction | metal cation:monoatomic cation antiporter activity | 1.42e-03 | 43 | 26 | 2 | GO:0140828 | |
| GeneOntologyMolecularFunction | secondary active transmembrane transporter activity | 6.51e-03 | 296 | 26 | 3 | GO:0015291 | |
| GeneOntologyMolecularFunction | active monoatomic ion transmembrane transporter activity | 6.82e-03 | 301 | 26 | 3 | GO:0022853 | |
| GeneOntologyMolecularFunction | antiporter activity | 1.38e-02 | 138 | 26 | 2 | GO:0015297 | |
| GeneOntologyMolecularFunction | endopeptidase activity | 1.79e-02 | 430 | 26 | 3 | GO:0004175 | |
| GeneOntologyBiologicalProcess | inorganic cation transmembrane transport | KCNK5 KCNH6 KCNH7 PSEN1 PKD2L2 PSEN2 SLC24A4 P2RX4 CATSPER2 SLC24A1 KCNH2 SLC6A14 | 3.21e-10 | 922 | 26 | 12 | GO:0098662 |
| GeneOntologyBiologicalProcess | monoatomic cation transmembrane transport | KCNK5 KCNH6 KCNH7 PSEN1 PKD2L2 PSEN2 SLC24A4 P2RX4 CATSPER2 SLC24A1 KCNH2 SLC6A14 | 4.10e-10 | 942 | 26 | 12 | GO:0098655 |
| GeneOntologyBiologicalProcess | metal ion transport | KCNK5 KCNH6 KCNH7 PSEN1 PKD2L2 PSEN2 SLC24A4 P2RX4 CATSPER2 SLC24A1 KCNH2 SLC6A14 | 8.12e-10 | 1000 | 26 | 12 | GO:0030001 |
| GeneOntologyBiologicalProcess | inorganic ion transmembrane transport | KCNK5 KCNH6 KCNH7 PSEN1 PKD2L2 PSEN2 SLC24A4 P2RX4 CATSPER2 SLC24A1 KCNH2 SLC6A14 | 9.85e-10 | 1017 | 26 | 12 | GO:0098660 |
| GeneOntologyBiologicalProcess | monoatomic ion transmembrane transport | KCNK5 KCNH6 KCNH7 PSEN1 PKD2L2 PSEN2 SLC24A4 P2RX4 CATSPER2 SLC24A1 KCNH2 SLC6A14 | 2.80e-09 | 1115 | 26 | 12 | GO:0034220 |
| GeneOntologyBiologicalProcess | monoatomic cation transport | KCNK5 KCNH6 KCNH7 PSEN1 PKD2L2 PSEN2 SLC24A4 P2RX4 CATSPER2 SLC24A1 KCNH2 SLC6A14 | 4.26e-09 | 1157 | 26 | 12 | GO:0006812 |
| GeneOntologyBiologicalProcess | monoatomic ion transport | KCNK5 KCNH6 KCNH7 PSEN1 PKD2L2 PSEN2 SLC24A4 P2RX4 CATSPER2 SLC24A1 KCNH2 SLC6A14 | 2.93e-08 | 1374 | 26 | 12 | GO:0006811 |
| GeneOntologyBiologicalProcess | import across plasma membrane | 3.44e-07 | 230 | 26 | 6 | GO:0098739 | |
| GeneOntologyBiologicalProcess | potassium ion transmembrane transport | 3.62e-07 | 232 | 26 | 6 | GO:0071805 | |
| GeneOntologyBiologicalProcess | calcium ion transmembrane transport | 4.09e-07 | 392 | 26 | 7 | GO:0070588 | |
| GeneOntologyBiologicalProcess | potassium ion transport | 9.18e-07 | 272 | 26 | 6 | GO:0006813 | |
| GeneOntologyBiologicalProcess | calcium ion transport | 2.34e-06 | 509 | 26 | 7 | GO:0006816 | |
| GeneOntologyBiologicalProcess | regulation of membrane potential | 4.35e-06 | 559 | 26 | 7 | GO:0042391 | |
| GeneOntologyBiologicalProcess | protein catabolic process at postsynapse | 9.15e-06 | 4 | 26 | 2 | GO:0140249 | |
| GeneOntologyBiologicalProcess | protein catabolic process at synapse | 2.28e-05 | 6 | 26 | 2 | GO:0140246 | |
| GeneOntologyBiologicalProcess | inorganic ion import across plasma membrane | 2.86e-05 | 142 | 26 | 4 | GO:0099587 | |
| GeneOntologyBiologicalProcess | inorganic cation import across plasma membrane | 2.86e-05 | 142 | 26 | 4 | GO:0098659 | |
| GeneOntologyBiologicalProcess | embryonic limb morphogenesis | 3.37e-05 | 148 | 26 | 4 | GO:0030326 | |
| GeneOntologyBiologicalProcess | embryonic appendage morphogenesis | 3.37e-05 | 148 | 26 | 4 | GO:0035113 | |
| GeneOntologyBiologicalProcess | membrane repolarization | 4.72e-05 | 56 | 26 | 3 | GO:0086009 | |
| GeneOntologyBiologicalProcess | Notch receptor processing | 6.83e-05 | 10 | 26 | 2 | GO:0007220 | |
| GeneOntologyBiologicalProcess | appendage morphogenesis | 8.03e-05 | 185 | 26 | 4 | GO:0035107 | |
| GeneOntologyBiologicalProcess | limb morphogenesis | 8.03e-05 | 185 | 26 | 4 | GO:0035108 | |
| GeneOntologyBiologicalProcess | regulation of resting membrane potential | 8.35e-05 | 11 | 26 | 2 | GO:0060075 | |
| GeneOntologyBiologicalProcess | skin morphogenesis | 1.59e-04 | 15 | 26 | 2 | GO:0043589 | |
| GeneOntologyBiologicalProcess | negative regulation of epidermal growth factor-activated receptor activity | 1.59e-04 | 15 | 26 | 2 | GO:0007175 | |
| GeneOntologyBiologicalProcess | limb development | 1.68e-04 | 224 | 26 | 4 | GO:0060173 | |
| GeneOntologyBiologicalProcess | appendage development | 1.68e-04 | 224 | 26 | 4 | GO:0048736 | |
| GeneOntologyBiologicalProcess | anagen | 1.81e-04 | 16 | 26 | 2 | GO:0042640 | |
| GeneOntologyBiologicalProcess | monoatomic cation homeostasis | 2.00e-04 | 705 | 26 | 6 | GO:0055080 | |
| GeneOntologyBiologicalProcess | export across plasma membrane | 2.01e-04 | 91 | 26 | 3 | GO:0140115 | |
| GeneOntologyBiologicalProcess | response to light intensity | 2.05e-04 | 17 | 26 | 2 | GO:0009642 | |
| GeneOntologyBiologicalProcess | monoatomic ion homeostasis | 2.19e-04 | 717 | 26 | 6 | GO:0050801 | |
| GeneOntologyBiologicalProcess | negative regulation of ubiquitin-protein transferase activity | 2.31e-04 | 18 | 26 | 2 | GO:0051444 | |
| GeneOntologyBiologicalProcess | positive regulation of receptor recycling | 2.31e-04 | 18 | 26 | 2 | GO:0001921 | |
| GeneOntologyBiologicalProcess | neuroinflammatory response | 2.73e-04 | 101 | 26 | 3 | GO:0150076 | |
| GeneOntologyBiologicalProcess | import into cell | 2.80e-04 | 1074 | 26 | 7 | GO:0098657 | |
| GeneOntologyBiologicalProcess | potassium ion export across plasma membrane | 3.16e-04 | 21 | 26 | 2 | GO:0097623 | |
| GeneOntologyBiologicalProcess | regulation of epidermal growth factor-activated receptor activity | 3.48e-04 | 22 | 26 | 2 | GO:0007176 | |
| GeneOntologyBiologicalProcess | sodium ion transport | 3.67e-04 | 275 | 26 | 4 | GO:0006814 | |
| GeneOntologyBiologicalProcess | hair cycle phase | 3.80e-04 | 23 | 26 | 2 | GO:0044851 | |
| GeneOntologyBiologicalProcess | organic anion transport | 4.05e-04 | 515 | 26 | 5 | GO:0015711 | |
| GeneOntologyBiologicalProcess | export from cell | 4.31e-04 | 1153 | 26 | 7 | GO:0140352 | |
| GeneOntologyBiologicalProcess | regulation of ventricular cardiac muscle cell membrane repolarization | 4.50e-04 | 25 | 26 | 2 | GO:0060307 | |
| GeneOntologyBiologicalProcess | dorsal/ventral neural tube patterning | 4.50e-04 | 25 | 26 | 2 | GO:0021904 | |
| GeneOntologyBiologicalProcess | heart contraction | 4.97e-04 | 298 | 26 | 4 | GO:0060047 | |
| GeneOntologyBiologicalProcess | membrane repolarization during cardiac muscle cell action potential | 5.26e-04 | 27 | 26 | 2 | GO:0086013 | |
| GeneOntologyBiologicalProcess | heart process | 5.69e-04 | 309 | 26 | 4 | GO:0003015 | |
| GeneOntologyBiologicalProcess | hair follicle maturation | 6.07e-04 | 29 | 26 | 2 | GO:0048820 | |
| GeneOntologyBiologicalProcess | endoplasmic reticulum calcium ion homeostasis | 6.07e-04 | 29 | 26 | 2 | GO:0032469 | |
| GeneOntologyBiologicalProcess | ventricular cardiac muscle cell membrane repolarization | 6.50e-04 | 30 | 26 | 2 | GO:0099625 | |
| GeneOntologyBiologicalProcess | regulation of cardiac muscle cell membrane repolarization | 6.50e-04 | 30 | 26 | 2 | GO:0099623 | |
| GeneOntologyBiologicalProcess | negative regulation of protein tyrosine kinase activity | 6.50e-04 | 30 | 26 | 2 | GO:0061099 | |
| GeneOntologyBiologicalProcess | membrane repolarization during action potential | 6.95e-04 | 31 | 26 | 2 | GO:0086011 | |
| GeneOntologyBiologicalProcess | regulation of receptor recycling | 6.95e-04 | 31 | 26 | 2 | GO:0001919 | |
| GeneOntologyBiologicalProcess | chemical homeostasis | 6.97e-04 | 1249 | 26 | 7 | GO:0048878 | |
| GeneOntologyBiologicalProcess | negative regulation of epidermal growth factor receptor signaling pathway | 7.40e-04 | 32 | 26 | 2 | GO:0042059 | |
| GeneOntologyBiologicalProcess | negative regulation of signaling receptor activity | 7.88e-04 | 33 | 26 | 2 | GO:2000272 | |
| GeneOntologyBiologicalProcess | positive regulation of coagulation | 8.36e-04 | 34 | 26 | 2 | GO:0050820 | |
| GeneOntologyBiologicalProcess | intracellular monoatomic cation homeostasis | 8.81e-04 | 611 | 26 | 5 | GO:0030003 | |
| GeneOntologyBiologicalProcess | anatomical structure maturation | 9.46e-04 | 354 | 26 | 4 | GO:0071695 | |
| GeneOntologyBiologicalProcess | intracellular monoatomic ion homeostasis | 9.54e-04 | 622 | 26 | 5 | GO:0006873 | |
| GeneOntologyBiologicalProcess | inorganic ion homeostasis | 9.54e-04 | 622 | 26 | 5 | GO:0098771 | |
| GeneOntologyBiologicalProcess | negative regulation of ERBB signaling pathway | 9.90e-04 | 37 | 26 | 2 | GO:1901185 | |
| GeneOntologyBiologicalProcess | intracellular calcium ion homeostasis | 9.97e-04 | 359 | 26 | 4 | GO:0006874 | |
| GeneOntologyBiologicalProcess | cardiac muscle contraction | 1.18e-03 | 167 | 26 | 3 | GO:0060048 | |
| GeneOntologyBiologicalProcess | cardiac muscle cell membrane repolarization | 1.22e-03 | 41 | 26 | 2 | GO:0099622 | |
| GeneOntologyBiologicalProcess | regulation of heart rate by cardiac conduction | 1.22e-03 | 41 | 26 | 2 | GO:0086091 | |
| GeneOntologyBiologicalProcess | regulation of membrane repolarization | 1.22e-03 | 41 | 26 | 2 | GO:0060306 | |
| GeneOntologyBiologicalProcess | calcium ion homeostasis | 1.34e-03 | 389 | 26 | 4 | GO:0055074 | |
| GeneOntologyBiologicalProcess | neural tube patterning | 1.46e-03 | 45 | 26 | 2 | GO:0021532 | |
| GeneOntologyBiologicalProcess | carboxylic acid transport | 1.63e-03 | 410 | 26 | 4 | GO:0046942 | |
| GeneOntologyBiologicalProcess | organic acid transport | 1.66e-03 | 412 | 26 | 4 | GO:0015849 | |
| GeneOntologyBiologicalProcess | regulation of ubiquitin-protein transferase activity | 1.66e-03 | 48 | 26 | 2 | GO:0051438 | |
| GeneOntologyBiologicalProcess | calcium ion import across plasma membrane | 1.66e-03 | 48 | 26 | 2 | GO:0098703 | |
| GeneOntologyBiologicalProcess | calcium ion import into cytosol | 1.66e-03 | 48 | 26 | 2 | GO:1902656 | |
| GeneOntologyBiologicalProcess | brain morphogenesis | 1.73e-03 | 49 | 26 | 2 | GO:0048854 | |
| GeneOntologyBiologicalProcess | potassium ion import across plasma membrane | 1.88e-03 | 51 | 26 | 2 | GO:1990573 | |
| GeneOntologyBiologicalProcess | action potential | 2.01e-03 | 201 | 26 | 3 | GO:0001508 | |
| GeneOntologyBiologicalProcess | membrane protein ectodomain proteolysis | 2.02e-03 | 53 | 26 | 2 | GO:0006509 | |
| GeneOntologyBiologicalProcess | biological phase | 2.02e-03 | 53 | 26 | 2 | GO:0044848 | |
| GeneOntologyBiologicalProcess | developmental maturation | 2.09e-03 | 439 | 26 | 4 | GO:0021700 | |
| GeneOntologyBiologicalProcess | receptor recycling | 2.18e-03 | 55 | 26 | 2 | GO:0001881 | |
| GeneOntologyBiologicalProcess | sodium ion transmembrane transport | 2.21e-03 | 208 | 26 | 3 | GO:0035725 | |
| GeneOntologyBiologicalProcess | amino acid import across plasma membrane | 2.42e-03 | 58 | 26 | 2 | GO:0089718 | |
| GeneOntologyBiologicalProcess | striated muscle contraction | 2.50e-03 | 217 | 26 | 3 | GO:0006941 | |
| GeneOntologyBiologicalProcess | calcium ion transmembrane import into cytosol | 2.50e-03 | 217 | 26 | 3 | GO:0097553 | |
| GeneOntologyBiologicalProcess | amyloid-beta formation | 2.50e-03 | 59 | 26 | 2 | GO:0034205 | |
| GeneOntologyBiologicalProcess | negative regulation of peptidyl-tyrosine phosphorylation | 2.50e-03 | 59 | 26 | 2 | GO:0050732 | |
| GeneOntologyBiologicalProcess | negative regulation of ubiquitin-dependent protein catabolic process | 2.67e-03 | 61 | 26 | 2 | GO:2000059 | |
| GeneOntologyBiologicalProcess | thymus development | 2.67e-03 | 61 | 26 | 2 | GO:0048538 | |
| GeneOntologyBiologicalProcess | positive regulation of organic acid transport | 2.85e-03 | 63 | 26 | 2 | GO:0032892 | |
| GeneOntologyBiologicalProcess | membrane protein proteolysis | 2.94e-03 | 64 | 26 | 2 | GO:0033619 | |
| GeneOntologyBiologicalProcess | amyloid-beta metabolic process | 3.40e-03 | 69 | 26 | 2 | GO:0050435 | |
| GeneOntologyBiologicalProcess | regulation of protein tyrosine kinase activity | 3.40e-03 | 69 | 26 | 2 | GO:0061097 | |
| GeneOntologyCellularComponent | gamma-secretase complex | 5.36e-05 | 7 | 34 | 2 | GO:0070765 | |
| GeneOntologyCellularComponent | monoatomic ion channel complex | 3.40e-04 | 378 | 34 | 5 | GO:0034702 | |
| HumanPheno | Semantic dementia | 1.06e-04 | 7 | 12 | 2 | HP:0030219 | |
| HumanPheno | Finger agnosia | 1.06e-04 | 7 | 12 | 2 | HP:0010525 | |
| HumanPheno | Abnormal atrioventricular conduction | 1.76e-04 | 131 | 12 | 4 | HP:0005150 | |
| HumanPheno | Atrioventricular nodal disease | 1.76e-04 | 131 | 12 | 4 | HP:0005142 | |
| HumanPheno | Anomic aphasia | 1.81e-04 | 9 | 12 | 2 | HP:0030784 | |
| HumanPheno | Deposits immunoreactive to beta-amyloid protein | 1.81e-04 | 9 | 12 | 2 | HP:0003791 | |
| HumanPheno | Alzheimer disease | 1.81e-04 | 9 | 12 | 2 | HP:0002511 | |
| HumanPheno | Heart block | 2.04e-04 | 136 | 12 | 4 | HP:0012722 | |
| HumanPheno | Senile plaques | 2.77e-04 | 11 | 12 | 2 | HP:0100256 | |
| HumanPheno | Fibular aplasia | 2.77e-04 | 11 | 12 | 2 | HP:0002990 | |
| Domain | K_chnl_volt-dep_ERG | 3.37e-09 | 3 | 29 | 3 | IPR003967 | |
| Domain | PAS_9 | 4.01e-07 | 10 | 29 | 3 | PF13426 | |
| Domain | NPIP | 1.21e-06 | 14 | 29 | 3 | IPR009443 | |
| Domain | K_chnl_volt-dep_EAG/ELK/ERG | 1.21e-06 | 14 | 29 | 3 | IPR003938 | |
| Domain | Peptidase_A22A | 2.33e-06 | 2 | 29 | 2 | IPR001108 | |
| Domain | Presenilin | 2.33e-06 | 2 | 29 | 2 | PF01080 | |
| Domain | PAS-assoc_C | 6.66e-06 | 24 | 29 | 3 | IPR000700 | |
| Domain | PAC | 8.54e-06 | 26 | 29 | 3 | IPR001610 | |
| Domain | PAC | 8.54e-06 | 26 | 29 | 3 | SM00086 | |
| Domain | PAC | 8.54e-06 | 26 | 29 | 3 | PS50113 | |
| Domain | CNMP_BINDING_1 | 1.62e-05 | 32 | 29 | 3 | PS00888 | |
| Domain | CNMP_BINDING_2 | 1.62e-05 | 32 | 29 | 3 | PS00889 | |
| Domain | cNMP | 1.95e-05 | 34 | 29 | 3 | SM00100 | |
| Domain | PAS | 1.95e-05 | 34 | 29 | 3 | IPR000014 | |
| Domain | PAS | 1.95e-05 | 34 | 29 | 3 | PS50112 | |
| Domain | cNMP_binding | 1.95e-05 | 34 | 29 | 3 | PF00027 | |
| Domain | cNMP-bd_dom | 2.13e-05 | 35 | 29 | 3 | IPR000595 | |
| Domain | CNMP_BINDING_3 | 2.13e-05 | 35 | 29 | 3 | PS50042 | |
| Domain | K/Na/Ca-exchanger | 2.32e-05 | 5 | 29 | 2 | IPR004481 | |
| Domain | cNMP-bd-like | 2.74e-05 | 38 | 29 | 3 | IPR018490 | |
| Domain | Ion_trans_dom | 2.78e-05 | 114 | 29 | 4 | IPR005821 | |
| Domain | Ion_trans | 2.78e-05 | 114 | 29 | 4 | PF00520 | |
| Domain | Preselin/SPP | 4.87e-05 | 7 | 29 | 2 | IPR006639 | |
| Domain | PSN | 4.87e-05 | 7 | 29 | 2 | SM00730 | |
| Domain | - | 5.55e-05 | 48 | 29 | 3 | 2.60.120.10 | |
| Domain | RmlC-like_jellyroll | 6.67e-05 | 51 | 29 | 3 | IPR014710 | |
| Domain | Na_Ca_ex | 8.32e-05 | 9 | 29 | 2 | PF01699 | |
| Domain | NaCa_Exmemb | 8.32e-05 | 9 | 29 | 2 | IPR004837 | |
| Domain | PAS | 6.83e-04 | 25 | 29 | 2 | PF00989 | |
| Domain | PAS_fold | 6.83e-04 | 25 | 29 | 2 | IPR013767 | |
| Domain | PAS | 1.12e-03 | 32 | 29 | 2 | SM00091 | |
| Pathway | REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS | 4.43e-05 | 41 | 24 | 3 | MM14546 | |
| Pathway | REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS | 5.12e-05 | 43 | 24 | 3 | M1056 | |
| Pathway | REACTOME_NONCANONICAL_ACTIVATION_OF_NOTCH3 | 7.73e-05 | 8 | 24 | 2 | M27887 | |
| Pathway | REACTOME_NOTCH4_ACTIVATION_AND_TRANSMISSION_OF_SIGNAL_TO_THE_NUCLEUS | 1.51e-04 | 11 | 24 | 2 | M27882 | |
| Pathway | REACTOME_SODIUM_CALCIUM_EXCHANGERS | 1.51e-04 | 11 | 24 | 2 | M27336 | |
| Pathway | REACTOME_TGFBR3_PTM_REGULATION | 1.51e-04 | 11 | 24 | 2 | M48251 | |
| Pathway | KEGG_MEDICUS_REFERENCE_NOTCH_PROTEOLYTIC_ACTIVATION | 1.51e-04 | 11 | 24 | 2 | M47865 | |
| Pathway | WP_INCLUSION_BODY_MYOSITIS | 1.51e-04 | 11 | 24 | 2 | M42545 | |
| Pathway | REACTOME_REGULATED_PROTEOLYSIS_OF_P75NTR | 1.51e-04 | 11 | 24 | 2 | M2661 | |
| Pathway | REACTOME_DISORDERS_OF_TRANSMEMBRANE_TRANSPORTERS | 2.10e-04 | 177 | 24 | 4 | M27476 | |
| Pathway | REACTOME_SODIUM_CALCIUM_EXCHANGERS | 2.14e-04 | 13 | 24 | 2 | MM15078 | |
| Pathway | KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_PSEN_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY | 3.29e-04 | 16 | 24 | 2 | M47695 | |
| Pathway | REACTOME_NRIF_SIGNALS_CELL_DEATH_FROM_THE_NUCLEUS | 3.29e-04 | 16 | 24 | 2 | M7257 | |
| Pathway | REACTOME_POTASSIUM_CHANNELS | 5.93e-04 | 98 | 24 | 3 | MM14545 | |
| Pathway | REACTOME_SLC_TRANSPORTER_DISORDERS | 6.11e-04 | 99 | 24 | 3 | M27474 | |
| Pathway | REACTOME_NOTCH2_ACTIVATION_AND_TRANSMISSION_OF_SIGNAL_TO_THE_NUCLEUS | 6.28e-04 | 22 | 24 | 2 | M27210 | |
| Pathway | REACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT | 6.45e-04 | 238 | 24 | 4 | MM15076 | |
| Pathway | REACTOME_POTASSIUM_CHANNELS | 6.86e-04 | 103 | 24 | 3 | M1073 | |
| Pathway | REACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT | 7.64e-04 | 249 | 24 | 4 | M5988 | |
| Pathway | REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES | 7.87e-04 | 108 | 24 | 3 | M823 | |
| Pathway | REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES | 8.09e-04 | 109 | 24 | 3 | MM15074 | |
| Pathway | REACTOME_NOTCH3_ACTIVATION_AND_TRANSMISSION_OF_SIGNAL_TO_THE_NUCLEUS | 8.14e-04 | 25 | 24 | 2 | M27879 | |
| Pathway | WP_CANONICAL_AND_NONCANONICAL_NOTCH_SIGNALING | 9.50e-04 | 27 | 24 | 2 | M39545 | |
| Pathway | REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS | 1.25e-03 | 31 | 24 | 2 | M592 | |
| Pathway | REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 | 1.34e-03 | 32 | 24 | 2 | M571 | |
| Pathway | REACTOME_SIGNALING_BY_NOTCH2 | 1.42e-03 | 33 | 24 | 2 | M604 | |
| Pathway | WP_NOTCH_SIGNALING_WP268 | 2.63e-03 | 45 | 24 | 2 | M39571 | |
| Pathway | WP_NOTCH_SIGNALING_PATHWAY | 2.75e-03 | 46 | 24 | 2 | MM15971 | |
| Pathway | KEGG_NOTCH_SIGNALING_PATHWAY | 2.87e-03 | 47 | 24 | 2 | M7946 | |
| Pathway | REACTOME_SIGNALING_BY_TGFBR3 | 3.11e-03 | 49 | 24 | 2 | M48250 | |
| Pathway | WP_TROP2_REGULATORY_SIGNALING | 3.11e-03 | 49 | 24 | 2 | M46458 | |
| Pathway | REACTOME_SIGNALING_BY_NOTCH3 | 3.11e-03 | 49 | 24 | 2 | M618 | |
| Pathway | REACTOME_EPH_EPHRIN_MEDIATED_REPULSION_OF_CELLS | 3.37e-03 | 51 | 24 | 2 | M27311 | |
| Pathway | BIOCARTA_HIVNEF_PATHWAY | 4.04e-03 | 56 | 24 | 2 | MM1406 | |
| Pathway | BIOCARTA_HIVNEF_PATHWAY | 4.04e-03 | 56 | 24 | 2 | M13968 | |
| Pathway | REACTOME_SIGNALING_BY_ERBB4 | 4.33e-03 | 58 | 24 | 2 | M544 | |
| Pathway | REACTOME_SIGNALING_BY_NOTCH1_PEST_DOMAIN_MUTANTS_IN_CANCER | 4.33e-03 | 58 | 24 | 2 | M29616 | |
| Pubmed | Potassium Ion Channel Protein (KCNH) Levels in Patients with Fibromyalgia Syndrome. | 7.78e-10 | 3 | 33 | 3 | 35818223 | |
| Pubmed | 7.78e-10 | 3 | 33 | 3 | 14643686 | ||
| Pubmed | HERG K(+) currents in human prolactin-secreting adenoma cells. | 7.78e-10 | 3 | 33 | 3 | 12634931 | |
| Pubmed | Bimodal regulation of an Elk subfamily K+ channel by phosphatidylinositol 4,5-bisphosphate. | 9.30e-08 | 10 | 33 | 3 | 26503718 | |
| Pubmed | Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development. | 2.06e-07 | 139 | 33 | 5 | 16985003 | |
| Pubmed | Presenilin 2 modulates endoplasmic reticulum (ER)-mitochondria interactions and Ca2+ cross-talk. | 8.73e-07 | 2 | 33 | 2 | 21285369 | |
| Pubmed | 8.73e-07 | 2 | 33 | 2 | 33973882 | ||
| Pubmed | Novel role of presenilins in maturation and transport of integrin beta 1. | 8.73e-07 | 2 | 33 | 2 | 18293935 | |
| Pubmed | 8.73e-07 | 2 | 33 | 2 | 16135086 | ||
| Pubmed | 8.73e-07 | 2 | 33 | 2 | 12460542 | ||
| Pubmed | Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo. | 8.73e-07 | 2 | 33 | 2 | 8755489 | |
| Pubmed | 8.73e-07 | 2 | 33 | 2 | 34067945 | ||
| Pubmed | 8.73e-07 | 2 | 33 | 2 | 37864790 | ||
| Pubmed | 8.73e-07 | 2 | 33 | 2 | 10662508 | ||
| Pubmed | 8.73e-07 | 2 | 33 | 2 | 34758364 | ||
| Pubmed | 8.73e-07 | 2 | 33 | 2 | 24699228 | ||
| Pubmed | Presenilins regulate synaptic plasticity in the perforant pathways of the hippocampus. | 8.73e-07 | 2 | 33 | 2 | 36710361 | |
| Pubmed | 8.73e-07 | 2 | 33 | 2 | 14566063 | ||
| Pubmed | Presenilin 1 and 2 are expressed differentially in the cerebral cortex of mice during development. | 8.73e-07 | 2 | 33 | 2 | 22796216 | |
| Pubmed | 8.73e-07 | 2 | 33 | 2 | 9073509 | ||
| Pubmed | 8.73e-07 | 2 | 33 | 2 | 17499883 | ||
| Pubmed | 8.73e-07 | 2 | 33 | 2 | 27177724 | ||
| Pubmed | Endogenous beta-amyloid production in presenilin-deficient embryonic mouse fibroblasts. | 8.73e-07 | 2 | 33 | 2 | 11715026 | |
| Pubmed | 8.73e-07 | 2 | 33 | 2 | 34102969 | ||
| Pubmed | Exploring the Role of PSEN Mutations in the Pathogenesis of Alzheimer's Disease. | 8.73e-07 | 2 | 33 | 2 | 32556937 | |
| Pubmed | 8.73e-07 | 2 | 33 | 2 | 15287885 | ||
| Pubmed | Novel presenilin mutations within Moroccan patients with Early-Onset Alzheimer's Disease. | 8.73e-07 | 2 | 33 | 2 | 24704512 | |
| Pubmed | 8.73e-07 | 2 | 33 | 2 | 34662541 | ||
| Pubmed | 8.73e-07 | 2 | 33 | 2 | 15537629 | ||
| Pubmed | 8.73e-07 | 2 | 33 | 2 | 10518543 | ||
| Pubmed | 8.73e-07 | 2 | 33 | 2 | 29867447 | ||
| Pubmed | MicroRNA Profiling in Aging Brain of PSEN1/PSEN2 Double Knockout Mice. | 8.73e-07 | 2 | 33 | 2 | 28879407 | |
| Pubmed | 8.73e-07 | 2 | 33 | 2 | 12885769 | ||
| Pubmed | Late onset familial Alzheimer's disease: novel presenilin 2 mutation and PS1 E318G polymorphism. | 8.73e-07 | 2 | 33 | 2 | 18350357 | |
| Pubmed | 8.73e-07 | 2 | 33 | 2 | 16620965 | ||
| Pubmed | Dysregulation of hypoxia-inducible factor by presenilin/γ-secretase loss-of-function mutations. | 8.73e-07 | 2 | 33 | 2 | 23365231 | |
| Pubmed | Changes in cholesterol metabolism are associated with PS1 and PS2 gene regulation in SK-N-BE. | 8.73e-07 | 2 | 33 | 2 | 17401156 | |
| Pubmed | 8.73e-07 | 2 | 33 | 2 | 36944398 | ||
| Pubmed | 8.73e-07 | 2 | 33 | 2 | 24018889 | ||
| Pubmed | Age and sex dependent alteration in presenilin expression in mouse cerebral cortex. | 8.73e-07 | 2 | 33 | 2 | 17874292 | |
| Pubmed | 8.73e-07 | 2 | 33 | 2 | 20573903 | ||
| Pubmed | Presenilin-2 and Calcium Handling: Molecules, Organelles, Cells and Brain Networks. | 8.73e-07 | 2 | 33 | 2 | 32992716 | |
| Pubmed | Two homologous genes causing early-onset familial Alzheimer's disease. | 8.73e-07 | 2 | 33 | 2 | 9246482 | |
| Pubmed | A {gamma}-secretase-independent mechanism of signal transduction by the amyloid precursor protein. | 8.73e-07 | 2 | 33 | 2 | 16103124 | |
| Pubmed | Identification of Structural Calcium Binding Sites in Membrane-Bound Presenilin 1 and 2. | 8.73e-07 | 2 | 33 | 2 | 32420742 | |
| Pubmed | Impaired default network functional connectivity in autosomal dominant Alzheimer disease. | 8.73e-07 | 2 | 33 | 2 | 23884042 | |
| Pubmed | 8.73e-07 | 2 | 33 | 2 | 12817569 | ||
| Pubmed | 8.73e-07 | 2 | 33 | 2 | 28106563 | ||
| Pubmed | 8.73e-07 | 2 | 33 | 2 | 17268505 | ||
| Pubmed | 8.73e-07 | 2 | 33 | 2 | 33413468 | ||
| Pubmed | 8.73e-07 | 2 | 33 | 2 | 31167792 | ||
| Pubmed | 8.73e-07 | 2 | 33 | 2 | 7651536 | ||
| Pubmed | 8.73e-07 | 2 | 33 | 2 | 37465679 | ||
| Pubmed | 8.73e-07 | 2 | 33 | 2 | 31376499 | ||
| Pubmed | 8.73e-07 | 2 | 33 | 2 | 18367332 | ||
| Pubmed | 8.73e-07 | 2 | 33 | 2 | 18297084 | ||
| Pubmed | Partial loss of presenilins causes seborrheic keratosis and autoimmune disease in mice. | 8.73e-07 | 2 | 33 | 2 | 15128703 | |
| Pubmed | Endoproteolysis of presenilin in vitro: inhibition by gamma-secretase inhibitors. | 8.73e-07 | 2 | 33 | 2 | 11876645 | |
| Pubmed | Partial loss of presenilin impairs age-dependent neuronal survival in the cerebral cortex. | 8.73e-07 | 2 | 33 | 2 | 25429133 | |
| Pubmed | 8.73e-07 | 2 | 33 | 2 | 21414900 | ||
| Pubmed | 8.73e-07 | 2 | 33 | 2 | 21914807 | ||
| Pubmed | 8.73e-07 | 2 | 33 | 2 | 19359372 | ||
| Pubmed | 8.73e-07 | 2 | 33 | 2 | 29078389 | ||
| Pubmed | Environment enrichment rescues the neurodegenerative phenotypes in presenilins-deficient mice. | 8.73e-07 | 2 | 33 | 2 | 17614943 | |
| Pubmed | Presenilins are enriched in endoplasmic reticulum membranes associated with mitochondria. | 8.73e-07 | 2 | 33 | 2 | 19834068 | |
| Pubmed | 8.73e-07 | 2 | 33 | 2 | 25323700 | ||
| Pubmed | 8.73e-07 | 2 | 33 | 2 | 18971484 | ||
| Pubmed | Presenilin Gene Mutation-associated Psychosis: Phenotypic Characteristics and Clinical Implications. | 8.73e-07 | 2 | 33 | 2 | 38227890 | |
| Pubmed | Genetic analyses of early-onset Alzheimer's disease using next generation sequencing. | 8.73e-07 | 2 | 33 | 2 | 31182772 | |
| Pubmed | Inactivation of presenilins causes pre-synaptic impairment prior to post-synaptic dysfunction. | 8.73e-07 | 2 | 33 | 2 | 20854432 | |
| Pubmed | 8.73e-07 | 2 | 33 | 2 | 17560791 | ||
| Pubmed | Epigenetic regulation of presenilin 1 and 2 in the cerebral cortex of mice during development. | 8.73e-07 | 2 | 33 | 2 | 25652771 | |
| Pubmed | 8.73e-07 | 2 | 33 | 2 | 36370840 | ||
| Pubmed | Identification of PSEN1 and PSEN2 gene mutations and variants in Turkish dementia patients. | 8.73e-07 | 2 | 33 | 2 | 22503161 | |
| Pubmed | PSEN1 and PSEN2 gene expression in Alzheimer's disease brain: a new approach. | 8.73e-07 | 2 | 33 | 2 | 24927704 | |
| Pubmed | Age-related neuropsychiatric symptoms in presenilins conditional double knockout mice. | 8.73e-07 | 2 | 33 | 2 | 23792007 | |
| Pubmed | Lack of evidence for presenilins as endoplasmic reticulum Ca2+ leak channels. | 8.73e-07 | 2 | 33 | 2 | 22311977 | |
| Pubmed | 8.73e-07 | 2 | 33 | 2 | 20953898 | ||
| Pubmed | Molecular signatures of neurodegeneration in the cortex of PS1/PS2 double knockout mice. | 8.73e-07 | 2 | 33 | 2 | 18834536 | |
| Pubmed | Loss of presenilin function enhances tau phosphorylation and aggregation in mice. | 8.73e-07 | 2 | 33 | 2 | 34593029 | |
| Pubmed | Presenilin-1 and presenilin-2 exhibit distinct yet overlapping gamma-secretase activities. | 8.73e-07 | 2 | 33 | 2 | 12684521 | |
| Pubmed | 8.73e-07 | 2 | 33 | 2 | 25204494 | ||
| Pubmed | 8.73e-07 | 2 | 33 | 2 | 11987239 | ||
| Pubmed | Specificity of presenilin-1- and presenilin-2-dependent γ-secretases towards substrate processing. | 8.73e-07 | 2 | 33 | 2 | 28994238 | |
| Pubmed | Adult neurogenesis is functionally associated with AD-like neurodegeneration. | 8.73e-07 | 2 | 33 | 2 | 17980611 | |
| Pubmed | Phenylpiperidine-type γ-secretase modulators target the transmembrane domain 1 of presenilin 1. | 8.73e-07 | 2 | 33 | 2 | 22002539 | |
| Pubmed | 8.73e-07 | 2 | 33 | 2 | 16014629 | ||
| Pubmed | 8.73e-07 | 2 | 33 | 2 | 19584449 | ||
| Pubmed | 8.73e-07 | 2 | 33 | 2 | 20701429 | ||
| Pubmed | Presence of presenilin 1/2 affects the invasion and replication of Salmonella typhimurium. | 8.73e-07 | 2 | 33 | 2 | 15922300 | |
| Pubmed | Aberrant splicing of PSEN2, but not PSEN1, in individuals with sporadic Alzheimer's disease. | 8.73e-07 | 2 | 33 | 2 | 35949106 | |
| Pubmed | 8.73e-07 | 2 | 33 | 2 | 28619096 | ||
| Pubmed | 8.73e-07 | 2 | 33 | 2 | 8574969 | ||
| Pubmed | 8.73e-07 | 2 | 33 | 2 | 18539391 | ||
| Pubmed | 8.73e-07 | 2 | 33 | 2 | 9521418 | ||
| Pubmed | Biology of presenilins as causative molecules for Alzheimer disease. | 8.73e-07 | 2 | 33 | 2 | 10361981 | |
| Pubmed | 8.73e-07 | 2 | 33 | 2 | 12846562 | ||
| Pubmed | Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein. | 8.73e-07 | 2 | 33 | 2 | 9450754 | |
| Pubmed | The mechanism of γ-Secretase dysfunction in familial Alzheimer disease. | 8.73e-07 | 2 | 33 | 2 | 22505025 | |
| Pubmed | 8.73e-07 | 2 | 33 | 2 | 9298903 | ||
| Cytoband | 16p12.2 | 2.83e-06 | 37 | 34 | 3 | 16p12.2 | |
| Cytoband | Ensembl 112 genes in cytogenetic band chr16p12 | 2.84e-04 | 172 | 34 | 3 | chr16p12 | |
| Cytoband | 16p11.2 | 3.86e-04 | 191 | 34 | 3 | 16p11.2 | |
| Cytoband | Ensembl 112 genes in cytogenetic band chr16p11 | 1.14e-03 | 278 | 34 | 3 | chr16p11 | |
| Cytoband | Ensembl 112 genes in cytogenetic band chr5q23 | 3.43e-03 | 117 | 34 | 2 | chr5q23 | |
| Cytoband | Ensembl 112 genes in cytogenetic band chr14q24 | 9.67e-03 | 200 | 34 | 2 | chr14q24 | |
| GeneFamily | Potassium voltage-gated channels | 1.30e-05 | 40 | 21 | 3 | 274 | |
| GeneFamily | Solute carriers | 1.00e-03 | 395 | 21 | 4 | 752 | |
| Coexpression | JINESH_BLEBBISHIELD_TRANSFORMED_STEM_CELL_SPHERES_DN | 2.28e-06 | 302 | 34 | 6 | M38975 | |
| Coexpression | JINESH_BLEBBISHIELD_VS_LIVE_CONTROL_UP | 8.52e-06 | 380 | 34 | 6 | M38974 | |
| Coexpression | JOHNSTONE_PARVB_TARGETS_1_DN | 7.87e-05 | 64 | 34 | 3 | M2237 | |
| ToppCell | PBMC-Control-Myeloid-Neutrophil-Neutrophil-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09) | 6.57e-06 | 160 | 34 | 4 | 70f3637dd0bcfcef421aa114f946fff0048f192e | |
| Drug | MK-499 | 1.07e-08 | 19 | 31 | 4 | CID000127718 | |
| Drug | Doxazosin | 4.56e-08 | 6 | 31 | 3 | DB00590 | |
| Drug | Prazosin | 4.56e-08 | 6 | 31 | 3 | DB00457 | |
| Drug | Terazosin | 4.56e-08 | 6 | 31 | 3 | DB01162 | |
| Drug | Miconazole | 1.27e-07 | 8 | 31 | 3 | DB01110 | |
| Drug | Ibutilide | 2.72e-07 | 10 | 31 | 3 | DB00308 | |
| Drug | WAY-123,398 | 2.72e-07 | 10 | 31 | 3 | CID000132160 | |
| Drug | S-182 | 1.79e-06 | 2 | 31 | 2 | CID003033995 | |
| Drug | N-(1-(2,3-dimethoxyphenyl)-4-methyl-3-penten-1-yl)-1-(5-bromofurfuryl)-1-piperidyl-4-amine | 1.79e-06 | 2 | 31 | 2 | ctd:C531033 | |
| Drug | Hdba | 2.18e-06 | 19 | 31 | 3 | CID000003896 | |
| Drug | clofilium | 3.03e-06 | 74 | 31 | 4 | CID000002798 | |
| Drug | ether-a | 3.46e-06 | 22 | 31 | 3 | CID000501025 | |
| Drug | NS1643 | 1.07e-05 | 4 | 31 | 2 | CID010177784 | |
| Drug | methanethiosulfonate | 1.13e-05 | 103 | 31 | 4 | CID004188587 | |
| Drug | XE991 | 1.21e-05 | 33 | 31 | 3 | CID000656732 | |
| Drug | diazoxide | 1.30e-05 | 227 | 31 | 5 | CID000003019 | |
| Drug | reazide | 1.79e-05 | 5 | 31 | 2 | CID000008820 | |
| Drug | mM Q | 2.35e-05 | 41 | 31 | 3 | CID000445446 | |
| Drug | niflumic acid | 2.43e-05 | 125 | 31 | 4 | CID000004488 | |
| Drug | linopirdine | 2.72e-05 | 43 | 31 | 3 | CID000003932 | |
| Drug | sodium | 2.86e-05 | 944 | 31 | 8 | CID000000923 | |
| Drug | astemizole | 3.12e-05 | 45 | 31 | 3 | CID000002247 | |
| Drug | CsCl | 3.38e-05 | 136 | 31 | 4 | CID000024293 | |
| Drug | sertindole | 4.29e-05 | 50 | 31 | 3 | CID000060149 | |
| Drug | time t | 5.11e-05 | 53 | 31 | 3 | CID000004790 | |
| Drug | ziprasidone | 5.11e-05 | 53 | 31 | 3 | CID000060853 | |
| Drug | E 4031 | 5.41e-05 | 54 | 31 | 3 | CID000003184 | |
| Drug | W-A-Y | 6.03e-05 | 56 | 31 | 3 | CID000004368 | |
| Drug | quetiapine | 6.36e-05 | 57 | 31 | 3 | CID000005002 | |
| Drug | terfenadine | 7.80e-05 | 61 | 31 | 3 | CID000005405 | |
| Drug | methylglucamine | 8.19e-05 | 62 | 31 | 3 | CID000004049 | |
| Drug | dofetilide | 8.59e-05 | 63 | 31 | 3 | CID000071329 | |
| Drug | hydroxyethylene dipeptide isostere | 9.79e-05 | 11 | 31 | 2 | CID005479484 | |
| Drug | carbanilide | 9.79e-05 | 11 | 31 | 2 | CID000007595 | |
| Drug | L-364,373 | 1.17e-04 | 12 | 31 | 2 | CID000656755 | |
| Drug | Exiproben | 1.17e-04 | 12 | 31 | 2 | CID000018995 | |
| Drug | Imidurea [39236-46-9]; Up 200; 10.4uM; MCF7; HT_HG-U133A | 1.37e-04 | 195 | 31 | 4 | 3522_UP | |
| Drug | AC1L9QP0 | 1.39e-04 | 13 | 31 | 2 | CID000453015 | |
| Drug | NSC 670881 | 1.39e-04 | 13 | 31 | 2 | CID000060874 | |
| Drug | AC1L6KTW | 1.39e-04 | 74 | 31 | 3 | CID000247705 | |
| Drug | Rubidium chromate | 1.39e-04 | 74 | 31 | 3 | CID000061605 | |
| Drug | Rifampicin [13292-46-1]; Up 200; 4.8uM; MCF7; HT_HG-U133A | 1.40e-04 | 196 | 31 | 4 | 2847_UP | |
| Drug | Phenelzine sulfate [156-51-4]; Down 200; 17uM; MCF7; HT_HG-U133A | 1.42e-04 | 197 | 31 | 4 | 3884_DN | |
| Drug | Gentamicine sulfate [1405-41-0]; Up 200; 2.6uM; PC3; HT_HG-U133A | 1.42e-04 | 197 | 31 | 4 | 5883_UP | |
| Drug | Harmaline hydrochloride dihydrate [6027-98-1]; Up 200; 14uM; MCF7; HT_HG-U133A | 1.42e-04 | 197 | 31 | 4 | 4968_UP | |
| Drug | Ceftazidime pentahydrate [78439-06-2]; Up 200; 6.2uM; PC3; HT_HG-U133A | 1.42e-04 | 197 | 31 | 4 | 5054_UP | |
| Drug | estradiol, USP; Down 200; 0.01uM; MCF7; HT_HG-U133A | 1.48e-04 | 199 | 31 | 4 | 5601_DN | |
| Drug | pisatin | 1.62e-04 | 14 | 31 | 2 | CID000101689 | |
| Drug | matrine | 1.62e-04 | 14 | 31 | 2 | ctd:C034244 | |
| Drug | thioridazine | 1.68e-04 | 79 | 31 | 3 | CID000005452 | |
| Drug | 77 B | 2.41e-04 | 17 | 31 | 2 | CID005494400 | |
| Drug | 3-(1H-pyrrole-2-carboxylate | 2.71e-04 | 233 | 31 | 4 | CID000005114 | |
| Drug | P-F-H | 3.02e-04 | 19 | 31 | 2 | CID000053657 | |
| Drug | Leu-asp-val | 3.36e-04 | 20 | 31 | 2 | CID000130816 | |
| Drug | potassium | 3.37e-04 | 1008 | 31 | 7 | CID000000813 | |
| Drug | itraconazole oral solution | 3.48e-04 | 101 | 31 | 3 | CID000003793 | |
| Drug | pyraclofos | 4.01e-04 | 106 | 31 | 3 | CID000093460 | |
| Drug | AC1NDOB4 | 4.46e-04 | 23 | 31 | 2 | CID004629010 | |
| Drug | cisapride | 4.71e-04 | 112 | 31 | 3 | CID000002769 | |
| Drug | ether | 4.84e-04 | 113 | 31 | 3 | CID000003283 | |
| Drug | Ad41 | 5.28e-04 | 25 | 31 | 2 | CID000073551 | |
| Drug | pimozide | 6.80e-04 | 127 | 31 | 3 | CID000016362 | |
| Drug | olanzapine | 7.11e-04 | 129 | 31 | 3 | CID000004585 | |
| Drug | piperidine | 7.27e-04 | 130 | 31 | 3 | CID000008082 | |
| Drug | risperidone | 8.29e-04 | 136 | 31 | 3 | CID000005073 | |
| Drug | amiloride | 8.42e-04 | 315 | 31 | 4 | CID000016230 | |
| Drug | lithium aluminum hydride | 8.93e-04 | 320 | 31 | 4 | CID000028112 | |
| Drug | chromanol 293B | 9.23e-04 | 33 | 31 | 2 | CID000121846 | |
| Drug | ropinirole | 9.23e-04 | 33 | 31 | 2 | CID000005095 | |
| Drug | CID5311039 | 1.04e-03 | 35 | 31 | 2 | CID005311039 | |
| Drug | barium | 1.06e-03 | 148 | 31 | 3 | CID000104810 | |
| Drug | AC1NDT8A | 1.16e-03 | 37 | 31 | 2 | CID004631218 | |
| Drug | AC1L1JOI | 1.16e-03 | 37 | 31 | 2 | CID000005135 | |
| Drug | CHAPSO | 1.22e-03 | 38 | 31 | 2 | CID000122145 | |
| Drug | LIGA20 | 1.29e-03 | 39 | 31 | 2 | CID006441213 | |
| Drug | Il 10 | 1.36e-03 | 40 | 31 | 2 | CID000146070 | |
| Disease | heart conduction disease (implicated_via_orthology) | 3.06e-08 | 32 | 30 | 4 | DOID:10273 (implicated_via_orthology) | |
| Disease | long QT syndrome (implicated_via_orthology) | 1.13e-07 | 10 | 30 | 3 | DOID:2843 (implicated_via_orthology) | |
| Disease | Alzheimer's disease 3 (implicated_via_orthology) | 9.99e-07 | 2 | 30 | 2 | DOID:0110042 (implicated_via_orthology) | |
| Disease | short QT syndrome (implicated_via_orthology) | 3.00e-06 | 3 | 30 | 2 | DOID:0050793 (implicated_via_orthology) | |
| Disease | early-onset Parkinson's disease (implicated_via_orthology) | 1.50e-05 | 6 | 30 | 2 | DOID:0060894 (implicated_via_orthology) | |
| Disease | Asphyxia Neonatorum | 1.50e-05 | 6 | 30 | 2 | C0004045 | |
| Disease | Early-onset autosomal dominant Alzheimer disease | 2.09e-05 | 7 | 30 | 2 | cv:CN043596 | |
| Disease | epilepsy (implicated_via_orthology) | 2.20e-05 | 163 | 30 | 4 | DOID:1826 (implicated_via_orthology) | |
| Disease | Alzheimer disease | 2.79e-05 | 8 | 30 | 2 | cv:C0002395 | |
| Disease | atrial fibrillation | 5.20e-04 | 371 | 30 | 4 | EFO_0000275 | |
| Disease | Primary dilated cardiomyopathy | 5.49e-04 | 34 | 30 | 2 | cv:C0007193 | |
| Disease | Duchenne muscular dystrophy (implicated_via_orthology) | 6.16e-04 | 36 | 30 | 2 | DOID:11723 (implicated_via_orthology) | |
| Disease | body weights and measures | 6.87e-04 | 38 | 30 | 2 | EFO_0004324 | |
| Disease | Familial dilated cardiomyopathy | 9.21e-04 | 44 | 30 | 2 | C0340427 |
| Peptide | Gene | Start | Entry |
|---|---|---|---|
| WFILLIFILEILLKW | 151 | Q96P56 | |
| KTLWLKIQKYLEIYW | 601 | A6NHC0 | |
| KIDLAYIWEEWPLLI | 1016 | Q9Y485 | |
| IVWWEGLVLIILYVF | 226 | Q8NFF2 | |
| YKVVITLWIVYLWVS | 71 | Q92617 | |
| QLLILAYVIGWVFVW | 36 | Q99571 | |
| YKVVITLWIVYLWVS | 71 | F8W0I5 | |
| LLTFLLWYLAWLDLE | 6 | P43026 | |
| LWYLAWLDLEFICTV | 11 | P43026 | |
| IAWWESLLLLLAYAF | 581 | O60721 | |
| FKAVWDWLILLLVIY | 406 | Q9NS40 | |
| FKAVWDWLILLLVIY | 406 | Q12809 | |
| KAVWDWLILLLVIYT | 256 | Q9H252 | |
| FVELWIYLGLAWLSL | 226 | O95279 | |
| YKVVITLWIVYLWVS | 71 | A8MRT5 | |
| YKVVITLWIVYLWVS | 71 | C9JG80 | |
| WLWYVKASLLILVIF | 296 | O00254 | |
| YKVVITLWIVYLWVS | 71 | E5RHQ5 | |
| RVVELSYWEWLPLLK | 731 | Q7L8L6 | |
| LILWRILYKKTLWYQ | 766 | Q9H799 | |
| EAELLWEVYLVLWAV | 151 | Q8IZ16 | |
| VIGDWLNLVFKWILF | 66 | P35575 | |
| YFLWHTYRWLLLKLL | 1956 | Q9HC10 | |
| YKVVITLWIVYLWVS | 71 | A6NJU9 | |
| WCLFWATVLLLIIYL | 241 | P59025 | |
| VVWWLNLLSIALYLL | 596 | Q9UKY4 | |
| VFIKYLPEWTAWLIL | 236 | P49768 | |
| LMLEAAYKLLWLLLW | 46 | Q5STR5 | |
| HLWYIWLLVVIGALL | 41 | Q4KMG9 | |
| LVFIKYLPEWSAWVI | 241 | P49810 | |
| YFKSIWNWLELLLLL | 311 | Q9NZM6 | |
| FKLWFDELIGLWVSV | 231 | Q14997 | |
| IYFVSLLAPWLEFWK | 271 | Q5GH77 | |
| YFWDDFWFVLKVVLI | 26 | Q9Y2P4 | |
| VWYLALCLLLAWLIV | 236 | Q9UN76 | |
| EIRWLLIVYAVLITW | 81 | P0C672 |