Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	catalytic activity, acting on DNA	DDX12P ATRX RTEL1 MEIOB POLG2 RUVBL2 TOP3A	4.40e-05	262	72	7	GO:0140097
GeneOntologyMolecularFunction	Toll-like receptor 2 binding	TLR1 TLR6	7.66e-05	4	72	2	GO:0035663
Domain	NFAT	NFATC3 NFAT5	1.41e-04	5	71	2	IPR008366
Domain	Toll-like_receptor	TLR1 TLR6	1.41e-04	5	71	2	IPR017241
Domain	LRRCT	TLR1 SLIT3 TLR6	2.41e-04	32	71	3	PF01463
Domain	RHD_dimer	NFATC3 NFAT5	6.29e-04	10	71	2	IPR032397
Domain	RHD_dimer	NFATC3 NFAT5	6.29e-04	10	71	2	PF16179
Domain	NFkB/Dor	NFATC3 NFAT5	6.29e-04	10	71	2	IPR000451
Domain	REL_1	NFATC3 NFAT5	6.29e-04	10	71	2	PS01204
Domain	RHD_DNA_bind_dom	NFATC3 NFAT5	6.29e-04	10	71	2	IPR011539
Domain	RHD_DNA_bind	NFATC3 NFAT5	6.29e-04	10	71	2	PF00554
Domain	Glyco_transf_8	GXYLT2 UGGT2	6.29e-04	10	71	2	PF01501
Domain	REL_2	NFATC3 NFAT5	6.29e-04	10	71	2	PS50254
Domain	Glyco_trans_8	GXYLT2 UGGT2	6.29e-04	10	71	2	IPR002495
Domain	-	NFATC3 NFAT5	6.29e-04	10	71	2	2.60.40.340
Domain	Fd_Rdtase_FAD-bd	DUOX1 NOS2	2.34e-03	19	71	2	IPR017927
Domain	FAD_FR	DUOX1 NOS2	2.34e-03	19	71	2	PS51384
Domain	Riboflavin_synthase-like_b-brl	DUOX1 NOS2	2.34e-03	19	71	2	IPR017938
Domain	TIR	TLR1 TLR6	2.86e-03	21	71	2	SM00255
Domain	TIR	TLR1 TLR6	3.13e-03	22	71	2	PF01582
Domain	-	TLR1 TLR6	3.42e-03	23	71	2	3.40.50.10140
Domain	TIR	TLR1 TLR6	3.73e-03	24	71	2	PS50104
Domain	TIR_dom	TLR1 TLR6	4.04e-03	25	71	2	IPR000157
Domain	IPT	NFATC3 NFAT5	4.70e-03	27	71	2	SM00429
Domain	Cys-rich_flank_reg_C	TLR1 SLIT3 TLR6	4.88e-03	90	71	3	IPR000483
Domain	LRRCT	TLR1 SLIT3 TLR6	4.88e-03	90	71	3	SM00082
Domain	TIG	NFATC3 NFAT5	6.17e-03	31	71	2	PF01833
Domain	IPT	NFATC3 NFAT5	6.57e-03	32	71	2	IPR002909
Domain	-	TRIML1 KMT2B ATRX TRIM4 DZIP3 FGD6	7.17e-03	449	71	6	3.30.40.10
Pubmed	Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals.	WNT3 PLA2G3 LAMA3 UGGT2 WDR37 RUVBL2	5.21e-07	142	72	6	19851296
Pubmed	Association of genetic variants with hemorrhagic stroke in Japanese individuals.	WNT3 PLA2G3 LAMA3 UGGT2 WDR37 RUVBL2	5.43e-07	143	72	6	20198315
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	TRIML1 GTPBP2 ACAD11 TRIM4 ZNF460 MLLT1 NUP188 SIPA1L2 WDR37 RUVBL2 ILVBL SAP30	2.93e-06	1116	72	12	31753913
Pubmed	Species-specific recognition of Aspergillus fumigatus by Toll-like receptor 1 and Toll-like receptor 6.	TLR1 TLR6	4.23e-06	2	72	2	22315281
Pubmed	Role of TLR1 and TLR6 in the host defense against disseminated candidiasis.	TLR1 TLR6	4.23e-06	2	72	2	18036178
Pubmed	The association of genetic variants in toll-like receptor 2 subfamily with allergy and asthma after hospitalization for bronchiolitis in infancy.	TLR1 TLR6	4.23e-06	2	72	2	24445834
Pubmed	[DISTRIBUTION OF TWO-LOCUS HAPLOTYPES OF MICROBIAL COMPONENT SENSOR GENES TLR1 AND TLR6 IN MAJOR POPULATIONS OF SOUTH URALS].	TLR1 TLR6	4.23e-06	2	72	2	26470427
Pubmed	Association of human TLR1 and TLR6 deficiency with altered immune responses to BCG vaccination in South African infants.	TLR1 TLR6	4.23e-06	2	72	2	21852947
Pubmed	Toll-like Receptor 1 743 A>G, 1805 T>G & Toll-like Receptor 6 745 C>T gene polymorphism and tuberculosis: a case control study of north Indian population from Agra (India).	TLR1 TLR6	4.23e-06	2	72	2	24984237
Pubmed	Cutting edge: functional interactions between toll-like receptor (TLR) 2 and TLR1 or TLR6 in response to phenol-soluble modulin.	TLR1 TLR6	4.23e-06	2	72	2	11123271
Pubmed	SNPs in the exons of Toll-like receptors are associated with susceptibility to type 1 diabetes in Chinese population.	TLR1 TLR6	4.23e-06	2	72	2	25261617
Pubmed	Emerging new role of NFAT5 in inducible nitric oxide synthase in response to hypoxia in mouse embryonic fibroblast cells.	NFAT5 NOS2	4.23e-06	2	72	2	31067085
Pubmed	Genetic ancestry effects on the distribution of toll-like receptors (TLRs) gene polymorphisms in a population of the Atlantic Forest, São Paulo, Brazil.	TLR1 TLR6	4.23e-06	2	72	2	29175392
Pubmed	Assignment of transcription factor NFAT5 to human chromosome 16q22.1, murine chromosome 8D and porcine chromosome 6p1.4 and comparison of the polyglutamine domains.	NFATC3 NFAT5	4.23e-06	2	72	2	11060450
Pubmed	The Roles of TLR Gene Polymorphisms in Atherosclerosis: A Systematic Review and Meta-Analysis of 35,317 Subjects.	TLR1 TLR6	4.23e-06	2	72	2	28474755
Pubmed	γ-Irradiated cancer cells promote tumor growth by activation of Toll-like receptor 1-mediated inducible nitric oxide synthase in macrophages.	TLR1 NOS2	4.23e-06	2	72	2	25632046
Pubmed	TOP3A amplification and ATRX inactivation are mutually exclusive events in pediatric osteosarcomas using ALT.	ATRX TOP3A	4.23e-06	2	72	2	35920001
Pubmed	A specific role for TLR1 in protective T(H)17 immunity during mucosal infection.	TLR1 TLR6	4.23e-06	2	72	2	22778390
Pubmed	Integrin CD11a cytoplasmic tail interacts with the CD45 membrane-proximal protein tyrosine phosphatase domain 1.	PTPRC ITGAL	4.23e-06	2	72	2	15946252
Pubmed	Heterozygous Arg753Gln polymorphism of human TLR-2 impairs immune activation by Borrelia burgdorferi and protects from late stage Lyme disease.	TLR1 TLR6	1.27e-05	3	72	2	16081826
Pubmed	Genetic variation in the toll-like receptor gene cluster (TLR10-TLR1-TLR6) and prostate cancer risk.	TLR1 TLR6	1.27e-05	3	72	2	18752252
Pubmed	Circular RNA mitochondrial translation optimization 1 homologue (CircMTO1) induced by zinc finger protein 460 (ZNF460) promotes oral squamous cell carcinoma progression through the microRNA miR-320a / alpha thalassemia/mental retardation, X-linked (ATRX) axis.	ATRX ZNF460	1.27e-05	3	72	2	34738503
Pubmed	Polymorphisms in TLR1, TLR6 and TLR10 genes and the risk of Graves' disease.	TLR1 TLR6	1.27e-05	3	72	2	25028161
Pubmed	Sublethal infection of C57BL/6 mice with Salmonella enterica Serovar Typhimurium leads to an increase in levels of Toll-like receptor 1 (TLR1), TLR2, and TLR9 mRNA as well as a decrease in levels of TLR6 mRNA in infected organs.	TLR1 TLR6	1.27e-05	3	72	2	15731092
Pubmed	Recognition of Coxiella burnetii by toll-like receptors and nucleotide-binding oligomerization domain-like receptors.	TLR1 TLR6	1.27e-05	3	72	2	25246533
Pubmed	The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors.	TLR1 TLR6	1.27e-05	3	72	2	11095740
Pubmed	IFNs activate toll-like receptor gene expression in viral infections.	TLR1 TLR6	1.27e-05	3	72	2	11607792
Pubmed	[Association of polymorphisms in toll-like receptor genes with atopic dermatitis in the Republic of Bashkortostan].	TLR1 TLR6	1.27e-05	3	72	2	25850295
Pubmed	Ureaplasma parvum lipoproteins, including MB antigen, activate NF-{kappa}B through TLR1, TLR2 and TLR6.	TLR1 TLR6	1.27e-05	3	72	2	18451040
Pubmed	Inhibition of ICAM-1/LFA-1 interactions prevents B-cell-dependent anti-CD45RB-induced transplantation tolerance.	PTPRC ITGAL	1.27e-05	3	72	2	18337659
Pubmed	TLR1- and TLR6-independent recognition of bacterial lipopeptides.	TLR1 TLR6	1.27e-05	3	72	2	16455646
Pubmed	Toll-like receptor polymorphisms are associated with increased neurosyphilis risk.	TLR1 TLR6	1.27e-05	3	72	2	24922103
Pubmed	Molecular mechanisms of TLR2-mediated antigen cross-presentation in dendritic cells.	TLR1 TLR6	1.27e-05	3	72	2	24683188
Pubmed	A dipalmitoylated lipoprotein from Mycoplasma pneumoniae activates NF-kappa B through TLR1, TLR2, and TLR6.	TLR1 TLR6	1.27e-05	3	72	2	16177110
Pubmed	Genetic variation in the Toll-like receptor gene cluster (TLR10-TLR1-TLR6) influences disease course in sarcoidosis.	TLR1 TLR6	1.27e-05	3	72	2	22150367
Pubmed	Toll-like receptor 1, 2 and 6 polymorphisms: no association with 11 serum cytokine concentrations.	TLR1 TLR6	1.27e-05	3	72	2	30028533
Pubmed	Human inducible nitric oxide synthase (iNOS) expression depends on chromosome region maintenance 1 (CRM1)- and eukaryotic translation initiation factor 4E (elF4E)-mediated nucleocytoplasmic mRNA transport.	XPO1 NOS2	1.27e-05	3	72	2	23471078
Pubmed	Recognition of lipopeptide patterns by Toll-like receptor 2-Toll-like receptor 6 heterodimer.	TLR1 TLR6	1.27e-05	3	72	2	19931471
Pubmed	Divergent roles of amino acid residues inside and outside the BB loop affect human Toll-like receptor (TLR)2/2, TLR2/1 and TLR2/6 responsiveness.	TLR1 TLR6	1.27e-05	3	72	2	23626692
Pubmed	Sequence variants in Toll-like receptor gene cluster (TLR6-TLR1-TLR10) and prostate cancer risk.	TLR1 TLR6	1.27e-05	3	72	2	15812078
Pubmed	Epistatic effect of TLR-1, -6 and -10 polymorphisms on organic dust-mediated cytokine response.	TLR1 TLR6	1.27e-05	3	72	2	28123183
Pubmed	Atherosclerosis induced by endogenous and exogenous toll-like receptor (TLR)1 or TLR6 agonists.	TLR1 TLR6	1.27e-05	3	72	2	22822027
Pubmed	TLR1, TLR2, and TLR6 gene polymorphisms are associated with increased susceptibility to complicated skin and skin structure infections.	TLR1 TLR6	1.27e-05	3	72	2	24511099
Pubmed	Full-exon resequencing reveals toll-like receptor variants contribute to human susceptibility to tuberculosis disease.	TLR1 TLR6	1.27e-05	3	72	2	18091991
Pubmed	TLR1 and TLR6 polymorphisms are associated with susceptibility to invasive aspergillosis after allogeneic stem cell transplantation.	TLR1 TLR6	1.27e-05	3	72	2	16461792
Pubmed	Toll-like receptor 2 subfamily gene polymorphisms are associated with Bacillus Calmette-Guérin osteitis following newborn vaccination.	TLR1 TLR6	1.27e-05	3	72	2	25605403
Pubmed	Saturated fatty acid activates but polyunsaturated fatty acid inhibits Toll-like receptor 2 dimerized with Toll-like receptor 6 or 1.	TLR1 TLR6	1.27e-05	3	72	2	14966134
Pubmed	Association between Toll-like receptor gene cluster (TLR6, TLR1, and TLR10) and prostate cancer.	TLR1 TLR6	1.27e-05	3	72	2	17932345
Pubmed	Toll-like receptor 2 subfamily genotypes are not associated with severity of bronchiolitis or postbronchiolitis wheezing in infants.	TLR1 TLR6	1.27e-05	3	72	2	24112285
Pubmed	Variation in the TLR10/TLR1/TLR6 locus is the major genetic determinant of interindividual difference in TLR1/2-mediated responses.	TLR1 TLR6	1.27e-05	3	72	2	23151486
Pubmed	Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins.	TLR1 TLR6	1.27e-05	3	72	2	12077222
Pubmed	Toll-like receptors 1 and 6 are involved in TLR2-mediated macrophage activation by hepatitis C virus core and NS3 proteins.	TLR1 TLR6	1.27e-05	3	72	2	17595379
Pubmed	Heterodimerization of TLR2 with TLR1 or TLR6 expands the ligand spectrum but does not lead to differential signaling.	TLR1 TLR6	1.27e-05	3	72	2	18056480
Pubmed	Toll-like receptor-1, -2, and -6 polymorphisms influence disease extension in inflammatory bowel diseases.	TLR1 TLR6	1.27e-05	3	72	2	16374251
Pubmed	TLR1/TLR2 heterodimers play an important role in the recognition of Borrelia spirochetes.	TLR1 TLR6	1.27e-05	3	72	2	21998742
Pubmed	Soluble Toll-like receptor 1 family members in the amniotic fluid of women with preterm prelabor rupture of the membranes.	TLR1 TLR6	1.27e-05	3	72	2	22280448
Pubmed	Indefinite survival of neonatal porcine islet xenografts by simultaneous targeting of LFA-1 and CD154 or CD45RB.	PTPRC ITGAL	1.27e-05	3	72	2	15677502
Pubmed	Toll-like receptor 2 expression on c-kit+ cells tracks the emergence of embryonic definitive hematopoietic progenitors.	PTPRC TLR1 TLR6	1.27e-05	22	72	3	31729371
Pubmed	Toll-like receptor heterodimer variants protect from childhood asthma.	TLR1 TLR6	2.53e-05	4	72	2	18547625
Pubmed	TLR2 is a primary receptor for Alzheimer's amyloid β peptide to trigger neuroinflammatory activation.	TLR1 TLR6	2.53e-05	4	72	2	22198949
Pubmed	NADPH oxidase deficient mice develop colitis and bacteremia upon infection with normally avirulent, TTSS-1- and TTSS-2-deficient Salmonella Typhimurium.	PTPRC NOS2	2.53e-05	4	72	2	24143212
Pubmed	A recombinant lipoprotein containing an unsaturated fatty acid activates NF-kappaB through the TLR2 signaling pathway and induces a differential gene profile from a synthetic lipopeptide.	TLR1 TLR6	2.53e-05	4	72	2	20478617
Pubmed	Novel engagement of CD14 and multiple toll-like receptors by group B streptococci.	TLR1 TLR6	2.53e-05	4	72	2	11739528
Pubmed	Toll-like receptor 2 is required for inflammatory responses to Francisella tularensis LVS.	TLR1 TLR6	2.53e-05	4	72	2	16622218
Pubmed	Association of Toll-like receptor polymorphisms with HIV status in North Americans.	TLR1 TLR6	2.53e-05	4	72	2	25253287
Pubmed	Racial variation in toll-like receptor variants among women with pelvic inflammatory disease.	TLR1 TLR6	2.53e-05	4	72	2	23255565
Pubmed	Polymorphisms in the toll-like receptor 2 subfamily and risk of asthma: a case-control analysis in a Chinese population.	TLR1 TLR6	2.53e-05	4	72	2	20815312
Pubmed	Human TLRs 10 and 1 share common mechanisms of innate immune sensing but not signaling.	TLR1 TLR6	2.53e-05	4	72	2	20348427
Pubmed	Lipopeptides are signaled by Toll-like receptor 1, 2 and 6 in endolysosomes.	TLR1 TLR6	2.53e-05	4	72	2	24860120
Pubmed	Structural basis for signal transduction by the Toll/interleukin-1 receptor domains.	TLR1 TLR6	2.53e-05	4	72	2	11081518
Pubmed	Identification and characterization of SAP25, a novel component of the mSin3 corepressor complex.	TTLL12 XPO1 SAP30	3.32e-05	30	72	3	16449650
Pubmed	STK40 Is a Pseudokinase that Binds the E3 Ubiquitin Ligase COP1.	PPP6C NFATC3 RUVBL2	3.67e-05	31	72	3	28089446
Pubmed	Association between toll-like receptors/CD14 gene polymorphisms and inflammatory bowel disease in Korean population.	TLR1 TLR6	4.21e-05	5	72	2	22219617
Pubmed	Variants in toll-like receptors 2 and 9 influence susceptibility to pulmonary tuberculosis in Caucasians, African-Americans, and West Africans.	TLR1 TLR6	4.21e-05	5	72	2	19771452
Pubmed	TLR6: A novel member of an expanding toll-like receptor family.	TLR1 TLR6	4.21e-05	5	72	2	10231569
Pubmed	Cutaneous Na+ storage strengthens the antimicrobial barrier function of the skin and boosts macrophage-driven host defense.	NFAT5 NOS2	4.21e-05	5	72	2	25738463
Pubmed	TLR2 and its co-receptors determine responses of macrophages and dendritic cells to lipoproteins of Mycobacterium tuberculosis.	TLR1 TLR6	4.21e-05	5	72	2	19362712
Pubmed	Toll-like receptor 2 mediates microglia/brain macrophage MT1-MMP expression and glioma expansion.	TLR1 TLR6	4.21e-05	5	72	2	24014382
Pubmed	Toll-like receptor gene polymorphisms confer susceptibility to graft-versus-host disease in allogenic hematopoietic stem cell transplantation.	TLR1 TLR6	4.21e-05	5	72	2	22703024
Pubmed	Association of MBL2, TLR1, TLR2 and TLR6 Polymorphisms With Production of IFN-γ and IL-12 in BCG Osteitis Survivors R1.	TLR1 TLR6	4.21e-05	5	72	2	27755461
Pubmed	TLR-dependent control of Francisella tularensis infection and host inflammatory responses.	TLR1 TLR6	4.21e-05	5	72	2	19936231
Pubmed	Lipopolysaccharide binding protein binds to triacylated and diacylated lipopeptides and mediates innate immune responses.	TLR1 TLR6	4.21e-05	5	72	2	15294986
Pubmed	Mac-1 (CD11b/CD18) and CD45 mediate the adhesion of hematopoietic progenitor cells to stromal cell elements via recognition of stromal heparan sulfate.	PTPRC ITGAL	4.21e-05	5	72	2	8043862
Pubmed	NFAT: ubiquitous regulator of cell differentiation and adaptation.	NFATC3 NFAT5	4.21e-05	5	72	2	11877454
Pubmed	Membrane sorting of toll-like receptor (TLR)-2/6 and TLR2/1 heterodimers at the cell surface determines heterotypic associations with CD36 and intracellular targeting.	TLR1 TLR6	4.21e-05	5	72	2	16880211
Pubmed	Abnormal high-density lipoprotein induces endothelial dysfunction via activation of Toll-like receptor-2.	TLR1 TLR6	4.21e-05	5	72	2	23477738
Pubmed	Interactions of sequence variants in interleukin-1 receptor-associated kinase4 and the toll-like receptor 6-1-10 gene cluster increase prostate cancer risk.	TLR1 TLR6	4.21e-05	5	72	2	16537705
Pubmed	A pooled investigation of Toll-like receptor gene variants and risk of non-Hodgkin lymphoma.	TLR1 TLR6	4.21e-05	5	72	2	19029192
Pubmed	NF-κB is activated from endosomal compartments in antiphospholipid antibodies-treated human monocytes.	TLR1 TLR6	4.21e-05	5	72	2	24612386
Pubmed	Role of TLR2-dependent IL-10 production in the inhibition of the initial IFN-γ T cell response to Porphyromonas gingivalis.	TLR1 TLR6	4.21e-05	5	72	2	23077245
Pubmed	Respiratory syncytial virus activates innate immunity through Toll-like receptor 2.	TLR1 TLR6	4.21e-05	5	72	2	19019963
Pubmed	The recombinant congenic strains--a novel genetic tool applied to the study of colon tumor development in the mouse.	GPD1 PTPRC ITGAL	4.86e-05	34	72	3	1686571
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	TTLL12 GTPBP2 ACAD11 ATRX UGGT2 RUVBL2 ILVBL TOP3A	5.96e-05	650	72	8	38777146
Pubmed	TLR2/6 signaling promotes the expansion of premalignant hematopoietic stem and progenitor cells in the NUP98-HOXD13 mouse model of MDS.	TLR1 TLR6	6.31e-05	6	72	2	32652111
Pubmed	Structural and functional understanding of the toll-like receptors.	TLR1 TLR6	6.31e-05	6	72	2	33576548
Pubmed	Genetic differences between five European populations.	TLR1 TLR6	6.31e-05	6	72	2	20616560
Pubmed	Conservation of dishevelled structure and function between flies and mice: isolation and characterization of Dvl2.	FER NOS2	6.31e-05	6	72	2	8887313
Pubmed	A strategy for probing the function of noncoding RNAs finds a repressor of NFAT.	NFATC3 NFAT5	6.31e-05	6	72	2	16141075
Pubmed	Toll-like receptor 9 acts at an early stage in host defence against pneumococcal infection.	TLR1 TLR6	6.31e-05	6	72	2	17004992
Pubmed	A Competitive binding mechanism between Skp1 and exportin 1 (CRM1) controls the localization of a subset of F-box proteins.	FBXO4 XPO1	6.31e-05	6	72	2	21378169
Cytoband	13q32.1	UGGT2 HS6ST3	2.87e-04	16	72	2	13q32.1
GeneFamily	Nuclear factors of activated T-cells	NFATC3 NFAT5	9.03e-05	5	55	2	665
GeneFamily	CD molecules\|Toll like receptors	TLR1 TLR6	4.03e-04	10	55	2	948
GeneFamily	DNA helicases	RTEL1 RUVBL2	1.20e-03	17	55	2	1167
Drug	Cephalothin sodium salt [58-71-9]; Down 200; 9.6uM; MCF7; HT_HG-U133A	GTPBP2 RSPH14 RTEL1 PLA2G3 FER NFAT5 PCDH9 TOP3A	2.03e-07	197	72	8	6819_DN
Drug	Mimosine [500-44-7]; Down 200; 20.2uM; MCF7; HT_HG-U133A	NFATC3 ABHD6 LAMA3 PLEKHB1 FGD6 PCDH9 TOP3A	3.19e-06	199	72	7	5302_DN
Drug	Iopamidol [60166-93-0]; Down 200; 5.2uM; HL60; HT_HG-U133A	RTEL1 ABHD6 DZIP3 ANKRD26 NUP188 PCDH9 TOP3A	3.19e-06	199	72	7	2732_DN
Drug	Fungal Polysaccharides	ATRX NFATC3 TLR1 TLR6 NOS2	3.73e-06	74	72	5	ctd:D062610
Drug	FSL-1 lipoprotein, synthetic	TLR1 TLR6 NOS2	2.83e-05	19	72	3	ctd:C460864
Drug	Protriptyline hydrochloride [1225-55-4]; Up 200; 13.4uM; MCF7; HT_HG-U133A	RTEL1 PLA2G3 FER KCTD2 PLEKHB1 PDLIM5	3.18e-05	191	72	6	6498_UP
Drug	Betahistine mesylate [54856-23-4]; Down 200; 17.2uM; MCF7; HT_HG-U133A	ATRX RTEL1 DZIP3 ANKRD26 NFAT5 PDLIM5	3.37e-05	193	72	6	2833_DN
Drug	Trolox [53188-07-1]; Down 200; 16uM; MCF7; HT_HG-U133A	RSPH14 RTEL1 NFATC3 ANKRD26 LAMA3 TOP3A	3.67e-05	196	72	6	6007_DN
Drug	Ivermectin [70288-86-7]; Down 200; 4.6uM; PC3; HT_HG-U133A	NFATC3 ABHD6 DZIP3 UGGT2 NFAT5 SAP30	3.67e-05	196	72	6	2051_DN
Drug	Quinic acid [86-68-0]; Down 200; 19.6uM; PC3; HT_HG-U133A	RSPH14 KMT2B RTEL1 WDR37 FGD6 SAP30	3.67e-05	196	72	6	7317_DN
Drug	Cyclosporin A [59865-13-3]; Down 200; 3.4uM; MCF7; HT_HG-U133A	RTEL1 NFATC3 ABHD6 FER ANKRD26 FGD6	3.78e-05	197	72	6	3267_DN
Drug	Naltrexone hydrochloride dihydrate [16676-29-2]; Down 200; 9.6uM; MCF7; HT_HG-U133A	KMT2B NFATC3 DZIP3 LAMA3 KCTD2 PDLIM5	3.89e-05	198	72	6	6241_DN
Drug	Moxonidine [75438-57-2]; Down 200; 16.6uM; MCF7; HT_HG-U133A	KMT2B KCTD2 PLEKHB1 PCDH9 SAP30 TOP3A	4.00e-05	199	72	6	7343_DN
Drug	Ketolides	GPD1 FHAD1 PRDM11 PPP6C ATRX SBF2 ABHD6 TXNDC17 ITPA	4.40e-05	531	72	9	ctd:D048628
Drug	glycerylcysteine	TLR1 TLR6	5.89e-05	4	72	2	CID000152469
Disease	aspergillosis (is_implicated_in)	TLR1 TLR6	1.58e-04	8	71	2	DOID:13564 (is_implicated_in)
Disease	gastric adenocarcinoma (is_implicated_in)	RTEL1 XPO1	3.10e-04	11	71	2	DOID:3717 (is_implicated_in)
Disease	Cardiovascular Abnormalities	WDR37 NOS2	6.70e-04	16	71	2	C0243050
Disease	perinatal necrotizing enterocolitis (biomarker_via_orthology)	TLR1 TLR6	7.58e-04	17	71	2	DOID:8677 (biomarker_via_orthology)
Disease	bipolar disorder, sex interaction measurement	SLIT3 SIPA1L2	8.52e-04	18	71	2	EFO_0008343, MONDO_0004985
Disease	asthma, allergic disease	RTEL1 TLR1 TLR6	9.26e-04	79	71	3	MONDO_0004979, MONDO_0005271
Disease	age of onset of asthma	PTPRC TLR1 TLR6	9.26e-04	79	71	3	OBA_2001001
Disease	age of onset of childhood onset asthma	RTEL1 NFATC3 TLR1	1.44e-03	92	71	3	OBA_2001015
Disease	Retinal Diseases	PTPRC NOS2	1.93e-03	27	71	2	C0035309
Disease	thrombocytopenia (is_implicated_in)	ANKRD26 ITPA	1.93e-03	27	71	2	DOID:1588 (is_implicated_in)
Disease	indole-3-propionate measurement	SLIT3 UNC13C	1.93e-03	27	71	2	EFO_0010501
Disease	tuberculosis (is_implicated_in)	TLR1 TLR6	2.07e-03	28	71	2	DOID:399 (is_implicated_in)
Disease	lung small cell carcinoma (is_implicated_in)	ATRX LAMA3	2.07e-03	28	71	2	DOID:5409 (is_implicated_in)
Disease	asthma	PRDM11 PTPRC RTEL1 TLR1 FER UNC13C NIBAN2	2.18e-03	751	71	7	MONDO_0004979

Protein segments in the cluster

Peptide	Gene	Start	Entry
IDGQVKRIHQFVECL	ABHD6	121	Q9BV23
RQLERVLKQPGCHKV	GTPBP2	331	Q9BX10
IPQIQKVCEVVDGFI	FBXO4	276	Q9UKT5
HREDGQNITPKICEV	CEP112	176	Q8N8E3
GHPEVVTLLVDRKCQ	ANKRD26	91	Q9UPS8
DNIVFHPKECRVIAV	ACAD11	226	Q709F0
FILPKAEVCVRNHVQ	NIBAN2	326	Q96TA1
QEVHPQVRKIGVFSC	DUOX1	1506	Q9NRD9
FRVGDCVIIENPLIQ	MEIOB	81	Q8N635
CETFDVRGKQHIQIP	NOS2	681	P35228
DQHECILPFVQVKGN	M1AP	71	Q8TC57
REHVVGKVCQRPENN	LAMA3	706	Q16787
CEFVPVEFHEIRQVK	SBF2	1336	Q86WG5
GKVLREENQCIAPVV	ARNTL2	11	Q8WYA1
VIQKGCFIEEVQVLH	C2CD6	211	Q53TS8
NGKVICFIEREVPFH	PCDH9	396	Q9HC56
VHTLCGRIPQVFLKQ	GXYLT2	406	A0PJZ3
IGVCFHPVFDTKQIR	POLG2	211	Q9UHN1
EPNCFSRVIHVEGQK	KMT2B	2656	Q9UMN6
VACGKPIRNNVFHLE	PDLIM5	506	Q96HC4
VKLEGHNEPVVLQVF	NFAT5	316	O94916
LQCDVPGIVKILFEV	DZIP3	326	Q86Y13
FGRHLVKNIRLEQPC	HS6ST3	161	Q8IZP7
GIKVIQPIECEFQRH	FSTL5	461	Q8N475
QPCQILKRIGHAVRV	GRIN3A	36	Q8TCU5
VVLDCQAHGEVPIKV	PRTG	56	Q2VWP7
EREEICHFPKGIKQI	ATRX	1021	P46100
ECHIQNVAVKLIPGD	FHAD1	66	B1AJZ9
QQCRDGHPVVVNILI	ILVBL	606	A1L0T0
DHPNIVKLIGVCTQR	FER	616	P16591
QRVLVKFIIGAHGCE	B3GALNT2	86	Q8NCR0
PAVHFAQVVKECRAV	DDX12P	621	Q92771
FVVPHQFIGKICDQL	GPD1	91	P21695
QTLIKEVGQRHCVDP	LYG2	81	Q86SG7
KCQEAVRQVQGPVLV	ITPA	56	Q9BY32
VRGPEQCDIQHFVEK	MLLT1	36	Q03111
LQQCTQEHAKEIPRF	SASS6	91	Q6UVJ0
GPVKHVYRVLQCQEE	KCTD2	181	Q14681
EEHLVCVQKGEVPNR	RBP5	91	P82980
QCPDGELQKRKEVVH	RUVBL2	226	Q9Y230
VRPHHKQQFEEVCIQ	RTEL1	956	Q9NZ71
IVGCHFRSIPVNEKD	SAP30	181	O75446
SDVRCVNEVIPKGHI	PRDM11	161	Q9NQV5
VFVIVKVHNPCTENV	SIPA1L2	731	Q9P2F8
CPVVFRQEILVQVIG	ITGAL	1021	P20701
PLIQIACGRVHIKEI	OR5M9	181	Q8NGP3
CEHQIGPREIEFQLL	PLA2G3	371	Q9NZ20
ICLHERNFVPGKSIV	TLR1	666	Q15399
HRFQCKGPVDINIVA	SLIT3	901	O75094
KKDFRQVIVNDCHLP	ZNF35	171	P13682
VRACKAVGHPFVIQL	XPO1	696	O14980
CFLVQHEQILPRVKP	ZNF460	181	Q14592
KIEFAQRIGHQRDCP	UNC13C	356	Q8NB66
RNQEIPHKGAFCDLV	PPP6C	181	O00743
REGKKQVCHFDVIPI	RSPH14	221	Q9UHP6
NVRDIKIGPECHDVQ	PLEKHB1	71	Q9UF11
GHRENLCVKQLVLEP	FGD6	121	Q6ZV73
EGVKLGIQECQHQFR	WNT3	71	P56703
IREKCQGAHIVLEVP	NFATC3	651	Q12968
ADVIQHCQRVKPIID	NUP188	556	Q5SRE5
VVLKQVHCEEFIPEF	TTLL12	521	Q14166
IGFEIIHVCKAVKPN	TOP3A	156	Q13472
KEDIQICLHERNFVP	TLR6	666	Q9Y2C9
ICLHERNFVPGKSIV	TLR6	671	Q9Y2C9
RCIHIGEKVDPVIEQ	TOB1	56	P50616
KGQHVREPVCKVGVF	TRIML1	396	Q8N9V2
CVQAEPVVREGLKHI	TXNDC17	46	Q9BRA2
PLKGVQEQQVRHECE	ZSCAN26	156	Q16670
VCVGQKIIALPHDNR	WDR37	416	Q9Y2I8
FVAVIDGEVLKPQCI	ZBED9	746	Q6R2W3
HQLFCQDVLKLRPGE	UGGT2	856	Q9NYU1
ERFQHLPCVLGKNVF	TRIM4	361	Q9C037
PELFENEHVRIGQKV	TBC1D19	221	Q8N5T2
FGDVVVKINQHKRCP	PTPRC	776	P08575
LCDIIVHIQGQPFRA	ZBTB34	31	Q8NCN2