Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	ZNF17 ZNF134 ZNF211 NFATC3 ZNF570 PEG3 ZNF566 GLIS3 ZNF286B ZNF75D POU3F4 ZNF518B TBR1 RREB1 ZNF883 ZNF829 ZNF681 ZNF445	1.88e-05	1412	84	18	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ZNF17 ZNF134 ZNF211 NFATC3 ZNF570 PEG3 ZNF566 GLIS3 ZNF286B ZNF75D POU3F4 ZNF518B TBR1 RREB1 ZNF883 ZNF829 ZNF681 ZNF445	2.91e-05	1459	84	18	GO:0000977
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ZNF17 ZNF134 ZNF211 NFATC3 ZNF570 GLIS3 ZNF286B ZNF75D POU3F4 TBR1 RREB1 ZNF883 ZNF829 ZNF681 ZNF445	1.93e-04	1244	84	15	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	ZNF17 ZNF134 ZNF211 NFATC3 ZNF570 GLIS3 ZNF286B ZNF75D POU3F4 TBR1 RREB1 ZNF883 ZNF829 ZNF681 ZNF445	2.44e-04	1271	84	15	GO:0000987
GeneOntologyMolecularFunction	damaged DNA binding	CUL4B ERCC4 RBBP8 XPA	4.35e-04	84	84	4	GO:0003684
GeneOntologyMolecularFunction	DNA endonuclease activity	ERCC4 RBBP8 DNA2	8.40e-04	44	84	3	GO:0004520
GeneOntologyBiologicalProcess	nucleotide-excision repair involved in interstrand cross-link repair	ERCC4 XPA	1.60e-05	2	83	2	GO:1901255
GeneOntologyBiologicalProcess	UV-damage excision repair	CUL4B POLA1 XPA	2.22e-05	14	83	3	GO:0070914
GeneOntologyCellularComponent	nucleotide-excision repair factor 1 complex	ERCC4 XPA	4.66e-05	3	83	2	GO:0000110
Domain	Znf_C2H2/integrase_DNA-bd	ZNF17 ZNF134 ZNF211 ZNF570 PEG3 ZNF566 GLIS3 ZNF286B ZNF200 ZNF75D ZNF407 ZNF518B RREB1 ZNF883 ZNF829 ZNF681 ZNF445	8.32e-09	694	83	17	IPR013087
Domain	-	ZNF17 ZNF134 ZNF211 ZNF570 PEG3 ZNF566 GLIS3 ZNF286B ZNF200 ZNF75D ZNF407 RREB1 ZNF883 ZNF829 ZNF681 ZNF445	4.18e-08	679	83	16	3.30.160.60
Domain	ZINC_FINGER_C2H2_2	ZNF17 ZNF134 ZNF211 ZNF570 PEG3 ZNF566 GLIS3 ZNF286B ZNF200 ZNF75D ZNF407 ZNF518B RREB1 ZNF883 ZNF829 ZNF681 ZNF445	4.20e-08	775	83	17	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF17 ZNF134 ZNF211 ZNF570 PEG3 ZNF566 GLIS3 ZNF286B ZNF200 ZNF75D ZNF407 ZNF518B RREB1 ZNF883 ZNF829 ZNF681 ZNF445	4.36e-08	777	83	17	PS00028
Domain	zf-C2H2	ZNF17 ZNF134 ZNF211 ZNF570 PEG3 ZNF566 GLIS3 ZNF286B ZNF200 ZNF75D ZNF407 RREB1 ZNF883 ZNF829 ZNF681 ZNF445	5.54e-08	693	83	16	PF00096
Domain	Znf_C2H2-like	ZNF17 ZNF134 ZNF211 ZNF570 PEG3 ZNF566 GLIS3 ZNF286B ZNF200 ZNF75D ZNF407 ZNF518B RREB1 ZNF883 ZNF829 ZNF681 ZNF445	6.18e-08	796	83	17	IPR015880
Domain	Znf_C2H2	ZNF17 ZNF134 ZNF211 ZNF570 PEG3 ZNF566 GLIS3 ZNF286B ZNF200 ZNF75D ZNF407 ZNF518B RREB1 ZNF883 ZNF829 ZNF681 ZNF445	7.27e-08	805	83	17	IPR007087
Domain	ZnF_C2H2	ZNF17 ZNF134 ZNF211 ZNF570 PEG3 ZNF566 GLIS3 ZNF286B ZNF200 ZNF75D ZNF407 ZNF518B RREB1 ZNF883 ZNF829 ZNF681 ZNF445	7.67e-08	808	83	17	SM00355
Domain	zf-C2H2_6	ZNF17 ZNF211 ZNF570 PEG3 ZNF566 ZNF200 RREB1 ZNF883 ZNF681 ZNF445	1.29e-06	314	83	10	PF13912
Domain	EIF3C_N_dom	EIF3C EIF3CL	1.95e-05	2	83	2	IPR008905
Domain	eIF-3c_N	EIF3C EIF3CL	1.95e-05	2	83	2	PF05470
Domain	EIF3C	EIF3C EIF3CL	1.95e-05	2	83	2	IPR027516
Domain	KRAB	ZNF17 ZNF211 ZNF570 ZNF566 ZNF75D ZNF829 ZNF681 ZNF445	1.90e-04	358	83	8	PS50805
Domain	KRAB	ZNF17 ZNF211 ZNF570 ZNF566 ZNF75D ZNF829 ZNF681 ZNF445	1.90e-04	358	83	8	PF01352
Domain	Groucho_enhance	TLE1 TLE3	1.93e-04	5	83	2	IPR009146
Domain	TLE_N	TLE1 TLE3	1.93e-04	5	83	2	PF03920
Domain	Groucho/TLE_N	TLE1 TLE3	1.93e-04	5	83	2	IPR005617
Domain	KRAB	ZNF17 ZNF211 ZNF570 ZNF566 ZNF75D ZNF829 ZNF681 ZNF445	2.34e-04	369	83	8	SM00349
Domain	KRAB	ZNF17 ZNF211 ZNF570 ZNF566 ZNF75D ZNF829 ZNF681 ZNF445	2.38e-04	370	83	8	IPR001909
Domain	-	TDRD6 RNF17	2.89e-04	6	83	2	2.40.50.90
Domain	Staphylococal_nuclease_OB-fold	TDRD6 RNF17	2.89e-04	6	83	2	IPR016071
Domain	p53-like_TF_DNA-bd	NFATC3 TBR1 FUT3	1.69e-03	53	83	3	IPR008967
Domain	TUDOR	TDRD6 RNF17	1.72e-03	14	83	2	PF00567
Domain	SCAN	PEG3 ZNF75D ZNF445	1.98e-03	56	83	3	SM00431
Domain	SCAN_BOX	PEG3 ZNF75D ZNF445	2.19e-03	58	83	3	PS50804
Domain	SCAN	PEG3 ZNF75D ZNF445	2.19e-03	58	83	3	PF02023
Domain	SCAN_dom	PEG3 ZNF75D ZNF445	2.19e-03	58	83	3	IPR003309
Domain	PINT	EIF3C EIF3CL	2.25e-03	16	83	2	SM00088
Domain	Retrov_capsid_C	PEG3 ZNF75D ZNF445	2.30e-03	59	83	3	IPR008916
Domain	PCI_dom	EIF3C EIF3CL	2.54e-03	17	83	2	IPR000717
Domain	PCI	EIF3C EIF3CL	2.54e-03	17	83	2	PF01399
Domain	TUDOR	TDRD6 RNF17	4.65e-03	23	83	2	PS50304
Domain	C2H2_Znf_fam	PEG3 ZNF518B	5.05e-03	24	83	2	IPR027775
Domain	TUDOR	TDRD6 RNF17	6.37e-03	27	83	2	SM00333
Domain	Tudor	TDRD6 RNF17	7.83e-03	30	83	2	IPR002999
Pubmed	CtIP promotes the motor activity of DNA2 to accelerate long-range DNA end resection.	RBBP8 DNA2	5.90e-06	2	85	2	32241893
Pubmed	EIF3C Promotes Lung Cancer Tumorigenesis by Regulating the APP/HSPA1A/LMNB1 Axis.	EIF3C EIF3CL	5.90e-06	2	85	2	36157221
Pubmed	Groucho/TLE family proteins and transcriptional repression.	TLE1 TLE3	5.90e-06	2	85	2	10831834
Pubmed	Differential functions of TLE1 and TLE3 depending on a specific phosphorylation site.	TLE1 TLE3	5.90e-06	2	85	2	33571907
Pubmed	Insulin-degrading enzyme deficiency in bone marrow cells increases atherosclerosis in LDL receptor-deficient mice.	IDE LDLR	5.90e-06	2	85	2	23684818
Pubmed	Nucleotide excision repair of abasic DNA lesions.	ERCC4 XPA	5.90e-06	2	85	2	31226203
Pubmed	Reduced levels of XPA, ERCC1 and XPF DNA repair proteins in testis tumor cell lines.	ERCC4 XPA	1.77e-05	3	85	2	15095299
Pubmed	Formation of a ternary complex by human XPA, ERCC1, and ERCC4(XPF) excision repair proteins.	ERCC4 XPA	1.77e-05	3	85	2	8197175
Pubmed	Epithelial expression and chromosomal location of human TLE genes: implications for notch signaling and neoplasia.	TLE1 TLE3	1.77e-05	3	85	2	8808280
Pubmed	The relationship between DNA repair genes (XPA, XPF, XPG) polymorphism and the risk of preeclampsia in Chinese Han Women.	ERCC4 XPA	1.77e-05	3	85	2	30527102
Pubmed	The structure-specific endonuclease Ercc1-Xpf is required to resolve DNA interstrand cross-link-induced double-strand breaks.	ERCC4 XPA	1.77e-05	3	85	2	15199134
Pubmed	Rescue of Mtp siRNA-induced hepatic steatosis by DGAT2 siRNA silencing.	DGAT2 LDLR	1.77e-05	3	85	2	22355095
Pubmed	The XPA-binding domain of ERCC1 is required for nucleotide excision repair but not other DNA repair pathways.	ERCC4 XPA	1.77e-05	3	85	2	19940136
Pubmed	Tle corepressors are differentially partitioned to instruct CD8+ T cell lineage choice and identity.	TLE1 TLE3	1.77e-05	3	85	2	30045946
Pubmed	BRCA1 and CtIP Are Both Required to Recruit Dna2 at Double-Strand Breaks in Homologous Recombination.	RBBP8 DNA2	1.77e-05	3	85	2	25909997
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	CUL4B PDS5B RBBP8 POLA1 TLE3 UBR4 EIF3C	2.10e-05	341	85	7	32971831
Pubmed	Expression of Groucho/TLE proteins during pancreas development.	TLE1 TLE3 POU3F4	2.75e-05	24	85	3	18778483
Pubmed	Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.	TLE1 GLIS3 IDE RREB1	3.01e-05	72	85	4	24509480
Pubmed	TLE expression correlates with mouse embryonic segmentation, neurogenesis, and epithelial determination.	TLE1 TLE3	3.53e-05	4	85	2	8645603
Pubmed	Interaction between the Ret finger protein and the Int-6 gene product and co-localisation into nuclear bodies.	EIF3C EIF3CL	3.53e-05	4	85	2	10504338
Pubmed	Dynamic expression of Groucho-related genes Grg1 and Grg3 in foregut endoderm and antagonism of differentiation.	TLE1 TLE3	3.53e-05	4	85	2	20108349
Pubmed	Polymorphisms of nucleotide-excision repair genes may contribute to sperm DNA fragmentation and male infertility.	ERCC4 XPA	3.53e-05	4	85	2	20864414
Pubmed	Groucho-mediated transcriptional repression establishes progenitor cell pattern and neuronal fate in the ventral neural tube.	TLE1 TLE3	3.53e-05	4	85	2	11290324
Pubmed	ERCC1-XPF targeting to psoralen-DNA crosslinks depends on XPA and FANCD2.	ERCC4 XPA	3.53e-05	4	85	2	31392348
Pubmed	Corepressors TLE1 and TLE3 interact with HESX1 and PROP1.	TLE1 TLE3	3.53e-05	4	85	2	20181723
Pubmed	A role for cell cycle-regulated phosphorylation in Groucho-mediated transcriptional repression.	TLE1 TLE3	3.53e-05	4	85	2	12397081
Pubmed	Reconstitution of human excision nuclease with recombinant XPF-ERCC1 complex.	ERCC4 XPA	3.53e-05	4	85	2	9013642
Pubmed	Modulation of Tcf3 repressor complex composition regulates cdx4 expression in zebrafish.	TLE1 TLE3	3.53e-05	4	85	2	21666599
Pubmed	CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation.	CUL4B TLE1 TLE3	4.42e-05	28	85	3	17041588
Pubmed	Interactions between exposure to environmental polycyclic aromatic hydrocarbons and DNA repair gene polymorphisms on bulky DNA adducts in human sperm.	ERCC4 XPA	5.87e-05	5	85	2	20957144
Pubmed	The winged-helix protein brain factor 1 interacts with groucho and hes proteins to repress transcription.	TLE1 TLE3	5.87e-05	5	85	2	11238932
Pubmed	RPA phosphorylation in mitosis alters DNA binding and protein-protein interactions.	POLA1 XPA	5.87e-05	5	85	2	12641457
Pubmed	Human homologs of a Drosophila Enhancer of split gene product define a novel family of nuclear proteins.	TLE1 TLE3	5.87e-05	5	85	2	1303260
Pubmed	Grg3, a murine Groucho-related gene, is expressed in the developing nervous system and in mesenchyme-induced epithelial structures.	TLE1 TLE3	5.87e-05	5	85	2	8989517
Pubmed	RNF17, a component of the mammalian germ cell nuage, is essential for spermiogenesis.	TDRD6 RNF17	5.87e-05	5	85	2	16093322
Pubmed	Conversion of low density lipoprotein-associated phosphatidylcholine to triacylglycerol by primary hepatocytes.	DGAT2 LDLR	5.87e-05	5	85	2	18175806
Pubmed	Red meat and poultry intake, polymorphisms in the nucleotide excision repair and mismatch repair pathways and colorectal cancer risk.	ERCC4 XPA	5.87e-05	5	85	2	19029193
Pubmed	Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein.	TLE1 TLE3	5.87e-05	5	85	2	8365415
Pubmed	Transducin-like enhancer of split proteins, the human homologs of Drosophila groucho, interact with hepatic nuclear factor 3beta.	TLE1 TLE3	5.87e-05	5	85	2	10748198
Pubmed	Evaluation of genetic risk loci for intracranial aneurysms in sporadic arteriovenous malformations of the brain.	STARD13 RBBP8	5.87e-05	5	85	2	25053769
Pubmed	Tissue specific mutagenic and carcinogenic responses in NER defective mouse models.	ERCC4 XPA	5.87e-05	5	85	2	16769089
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	GREB1L ZZZ3 RBBP8 TLE1 TLE3 UBR4 RREB1	7.60e-05	418	85	7	34709266
Pubmed	Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q.	NFATC3 HPR EIF3C EIF3CL	7.88e-05	92	85	4	10493829
Pubmed	Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.	ZNF17 ZNF211 ZNF566 ZNF681 ZNF445	8.46e-05	181	85	5	37372979
Pubmed	ERCC1 function in nuclear excision and interstrand crosslink repair pathways is mediated exclusively by the ERCC1-202 isoform.	ERCC4 XPA	8.80e-05	6	85	2	24036546
Pubmed	Premature aging in mice activates a systemic metabolic response involving autophagy induction.	ERCC4 XPA	8.80e-05	6	85	2	18443001
Pubmed	Low-density lipoprotein receptor represents an apolipoprotein E-independent pathway of Aβ uptake and degradation by astrocytes.	IDE LDLR	8.80e-05	6	85	2	22383525
Pubmed	Transcripts of Grg4, a murine groucho-related gene, are detected in adjacent tissues to other murine neurogenic gene homologues during embryonic development.	TLE1 TLE3	8.80e-05	6	85	2	8892234
Pubmed	Protein characterization and targeted disruption of Grg, a mouse gene related to the groucho transcript of the Drosophila Enhancer of split complex.	TLE1 TLE3	8.80e-05	6	85	2	8573724
Pubmed	Interindividual variation in nucleotide excision repair genes and risk of endometrial cancer.	ERCC4 XPA	8.80e-05	6	85	2	16284373
Pubmed	Common variations in ERCC2 are associated with response to cisplatin chemotherapy and clinical outcome in osteosarcoma patients.	ERCC4 XPA	8.80e-05	6	85	2	19434073
Pubmed	WDR62 is required for centriole duplication in spermatogenesis and manchette removal in spermiogenesis.	TDRD6 TBR1 MAPKBP1	1.12e-04	38	85	3	34059773
Pubmed	Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	GREB1L DCLK3 ZNF407 ZNF518B	1.18e-04	102	85	4	11214970
Pubmed	Polymorphisms in DNA damage response genes and head and neck cancer risk.	ERCC4 XPA	1.23e-04	7	85	2	20429839
Pubmed	A Gro/TLE-NuRD corepressor complex facilitates Tbx20-dependent transcriptional repression.	TLE1 TLE3	1.23e-04	7	85	2	24024827
Pubmed	A genome-wide association study identifies novel risk loci for type 2 diabetes.	EXT2 IDE	1.23e-04	7	85	2	17293876
Pubmed	Nucleotide excision repair pathway genes and oral premalignant lesions.	ERCC4 XPA	1.23e-04	7	85	2	17575242
Pubmed	Glucose-Dependent Insulinotropic Polypeptide Stimulates Osteopontin Expression in the Vasculature via Endothelin-1 and CREB.	NFATC3 LDLR	1.23e-04	7	85	2	26395740
Pubmed	A summary of mutations in the UV-sensitive disorders: xeroderma pigmentosum, Cockayne syndrome, and trichothiodystrophy.	ERCC4 XPA	1.23e-04	7	85	2	10447254
Pubmed	Genome-wide association study of intracranial aneurysm identifies three new risk loci.	STARD13 RBBP8	1.23e-04	7	85	2	20364137
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	PDS5B TLE3 PEG3 ZNF566 GLIS3 ZNF286B LENG9 ZNF681 ZNF445	1.61e-04	808	85	9	20412781
Pubmed	A comparison of Notch, Hes and Grg expression during murine embryonic and post-natal development.	TLE1 TLE3	1.64e-04	8	85	2	10512199
Pubmed	Generation of an integrated transcription map of the BRCA2 region on chromosome 13q12-q13.	STARD13 PDS5B	1.64e-04	8	85	2	8812419
Pubmed	Six3 and Six6 activity is modulated by members of the groucho family.	TLE1 TLE3	1.64e-04	8	85	2	12441302
Pubmed	The Groucho-related gene family regulates the gonadotropin-releasing hormone gene through interaction with the homeodomain proteins MSX1 and OCT1.	TLE1 TLE3	1.64e-04	8	85	2	16002402
Pubmed	Gene-environment interaction involved in oral carcinogenesis: molecular epidemiological study for metabolic and DNA repair gene polymorphisms.	ERCC4 XPA	1.64e-04	8	85	2	16393248
Pubmed	Common variants in CDKAL1, CDKN2A/B, IGF2BP2, SLC30A8, and HHEX/IDE genes are associated with type 2 diabetes and impaired fasting glucose in a Chinese Han population.	EXT2 IDE	1.64e-04	8	85	2	18633108
Pubmed	Nolz1 promotes striatal neurogenesis through the regulation of retinoic acid signaling.	TLE1 TLE3	1.64e-04	8	85	2	20735826
Pubmed	FANCD2 binds CtIP and regulates DNA-end resection during DNA interstrand crosslink repair.	ERCC4 RBBP8	1.64e-04	8	85	2	24794430
Pubmed	Constitutive scaffolding of multiple Wnt enhanceosome components by Legless/BCL9.	TLE1 TLE3	1.64e-04	8	85	2	28296634
Pubmed	Tagging genes with cassette-exchange sites.	DOCK9 UBR4 EIF3C RNF17 ZNF681 EIF3CL	1.76e-04	335	85	6	15741177
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	PDS5B RTCB POLA1 VPS13C UBR4 EIF3C IDE TDRD6 PFKL EIF3CL VAT1 SEPTIN2	1.77e-04	1425	85	12	30948266
Pubmed	The pleiotropic mouse phenotype extra-toes spotting is caused by translation initiation factor Eif3c mutations and is associated with disrupted sonic hedgehog signaling.	EIF3C EIF3CL	2.10e-04	9	85	2	21292980
Pubmed	Xeroderma Pigmentosum	ERCC4 XPA	2.10e-04	9	85	2	20301571
Pubmed	The m subunit of murine translation initiation factor eIF3 maintains the integrity of the eIF3 complex and is required for embryonic development, homeostasis, and organ size control.	EIF3C EIF3CL	2.10e-04	9	85	2	24003236
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	CUL4B RTCB POLA1 TLE3 UBR4 EIF3C IDE PFKL GMPPA EIF3CL VAT1 SEPTIN2	2.14e-04	1455	85	12	22863883
Pubmed	Systematic identification of cancer cell vulnerabilities to natural killer cell-mediated immune surveillance.	CUL4B PTS EXT2 GMPPA SEPTIN2	2.38e-04	226	85	5	31452512
Pubmed	Rapid and efficient cloning of cDNAs encoding Krüppel-like zinc finger proteins by degenerate PCR.	ZNF566 ZNF681 ZNF445	2.39e-04	49	85	3	9630514
Pubmed	mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events.	EIF3C EIF3CL	2.62e-04	10	85	2	16286006
Pubmed	ERCC1 haplotypes modify bladder cancer risk: a case-control study.	ERCC4 XPA	2.62e-04	10	85	2	20061190
Pubmed	Conservation and diversity of eukaryotic translation initiation factor eIF3.	EIF3C EIF3CL	2.62e-04	10	85	2	8995409
Pubmed	Spatial distribution of the full-length members of the Grg family during embryonic neurogenesis reveals a "Grg-mediated repression map" in the mouse telencephalon.	TLE1 TLE3	2.62e-04	10	85	2	30571765
Pubmed	Grg3/TLE3 and Grg1/TLE1 induce monohormonal pancreatic β-cells while repressing α-cell functions.	TLE1 TLE3	2.62e-04	10	85	2	24487024
Pubmed	Identification, chromosomal location, and genome organization of mammalian G-protein-coupled receptors.	HPR MCC LDLR	2.86e-04	52	85	3	8288218
Pubmed	Coexpression of Cux-1 and Notch signaling pathway components during kidney development.	TLE1 TLE3	3.20e-04	11	85	2	15499562
Pubmed	Strong functional interactions of TFIIH with XPC and XPG in human DNA nucleotide excision repair, without a preassembled repairosome.	ERCC4 XPA	3.20e-04	11	85	2	11259578
Pubmed	The association of microcephaly protein WDR62 with CPAP/IFT88 is required for cilia formation and neocortical development.	TBR1 MAPKBP1	3.20e-04	11	85	2	31816041
Pubmed	Polymorphism in nucleotide excision repair gene XPC correlates with bleomycin-induced chromosomal aberrations.	ERCC4 XPA	3.20e-04	11	85	2	17685459
Pubmed	A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.	VPS13C GLIS3 RREB1	3.37e-04	55	85	3	22581228
Pubmed	The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis.	TLE1 SLC39A6 EIF3C TBR1 EIF3CL	3.45e-04	245	85	5	19521500
Pubmed	FAM46C and FNDC3A Are Multiple Myeloma Tumor Suppressors That Act in Concert to Impair Clearing of Protein Aggregates and Autophagy.	RTCB IDE PFKL GMPPA VAT1	3.65e-04	248	85	5	32963011
Pubmed	Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor elF3.	EIF3C EIF3CL	3.83e-04	12	85	2	14519125
Pubmed	Reconstitution reveals the functional core of mammalian eIF3.	EIF3C EIF3CL	3.83e-04	12	85	2	17581632
Pubmed	International Lung Cancer Consortium: pooled analysis of sequence variants in DNA repair and cell cycle pathways.	ERCC4 XPA	3.83e-04	12	85	2	18990748
Pubmed	RPA governs endonuclease switching during processing of Okazaki fragments in eukaryotes.	POLA1 DNA2	3.83e-04	12	85	2	11473323
Pubmed	Af9/Mllt3 interferes with Tbr1 expression through epigenetic modification of histone H3K79 during development of the cerebral cortex.	TLE3 TBR1	3.83e-04	12	85	2	20348416
Pubmed	Aging and chronic DNA damage response activate a regulatory pathway involving miR-29 and p53.	ERCC4 XPA	3.83e-04	12	85	2	21522133
Pubmed	All Tcf HMG box transcription factors interact with Groucho-related co-repressors.	TLE1 TLE3	3.83e-04	12	85	2	11266540
Pubmed	Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.	CUL4B CAPN8 EIF3C CHI3L2 LDLR SMURF2 PTK6 EIF3CL	4.21e-04	730	85	8	34857952
Pubmed	Analysis of novel risk loci for type 2 diabetes in a general French population: the D.E.S.I.R. study.	EXT2 LDLR	4.52e-04	13	85	2	18210030
Cytoband	19q13.4	ZNF17 ZNF134 ZNF211 PEG3 LENG9	3.68e-07	79	84	5	19q13.4
Cytoband	19q13.12	ZNF570 ZNF566 ZNF829	3.22e-04	72	84	3	19q13.12
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	ZNF17 ZNF134 ZNF211 ZNF570 PEG3 ZNF566 TMEM143 LENG9 ZNF829	3.35e-04	1192	84	9	chr19q13
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF17 ZNF134 ZNF211 ZNF570 PEG3 ZNF566 GLIS3 ZNF286B ZNF200 ZNF75D ZNF407 ZNF518B RREB1 ZNF883 ZNF829 ZNF681 ZNF445	7.33e-11	718	59	17	28
GeneFamily	WD repeat domain containing\|Xeroderma pigmentosum complementation groups\|Nucleotide excision repair	ERCC4 XPA	2.89e-04	8	59	2	1125
ToppCell	CD8+_Memory_T_cell-CV-7\|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster	MMS22L ZZZ3 VPS13C DNA2 CBLB LDLR	1.79e-06	191	85	6	9454f642c3621370fa23640b631301346b300950
ToppCell	3'-Parenchyma_lung-Epithelial-Epithelial_transtional-epithelial_cell_of_lung-Transitional_Club-AT2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CAPN8 PTCHD1 GLIS3 SLC39A6 DAPK1 LDLR	1.96e-06	194	85	6	5b29c843186c2394f5bec3b1d5ae284a0d931d85
ToppCell	3'-Parenchyma_lung-Epithelial-Epithelial_transtional\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CAPN8 PTCHD1 GLIS3 SLC39A6 DAPK1 LDLR	1.96e-06	194	85	6	ebcf6c6d0eb20a5d422becf5a730089230c8ba9a
ToppCell	3'-Parenchyma_lung-Epithelial-Epithelial_transtional-epithelial_cell_of_lung\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CAPN8 PTCHD1 GLIS3 SLC39A6 DAPK1 LDLR	1.96e-06	194	85	6	8c6e5ba27a988e0cd6b8c25cb9a30a0da2b1f7f9
ToppCell	3'-Parenchyma_lung-Epithelial-Epithelial_transtional-epithelial_cell_of_lung-Transitional_Club-AT2-Transitional_Club-AT2_L.0.4.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CAPN8 PTCHD1 GLIS3 SLC39A6 DAPK1 LDLR	1.96e-06	194	85	6	6e78e3046c5b172af92a84e25f982377a0aaac58
ToppCell	tumor_Lymph_Node_/_Brain-B_lymphocytes-Undetermined\|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass	DGAT2 ZNF518B BANK1 ZNF829 ZNF681	1.16e-05	154	85	5	e16f200391537aa1002b0079481b94e1fb86b9ad
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	FAP DOCK9 RNF17 SH2D7 SMURF2	1.62e-05	165	85	5	a74751e0ec857aa974bec04ccc747c004a8f6e01
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MMS22L POLA1 CENPU DNA2 SH2D7	1.81e-05	169	85	5	121768fc51fc3441ec725346a1bbe29e21d05971
ToppCell	E16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-Chondrocyte-Chondrocyte_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MMS22L NFATC3 PEG3 GLIS3 PAM	2.14e-05	175	85	5	a5db428b078938627e61b7e944c1e0c1d61ac2da
ToppCell	E16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-Chondrocyte\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MMS22L NFATC3 PEG3 GLIS3 PAM	2.14e-05	175	85	5	8b498eea1ec1c1f27b171025c3d08adf3687bafc
ToppCell	Control-Epithelial_cells-Airway_club\|Control / group, cell type (main and fine annotations)	CAPN8 PTCHD1 GLIS3 DAPK1 LDLR	2.52e-05	181	85	5	c755d23dd9aabc717dc73e2b3fa99a1f751e6507
ToppCell	CV-Healthy-7\|CV / Virus stimulation, Condition and Cluster	MMS22L POLA1 DOCK9 ZNF829 ZNF681	2.73e-05	184	85	5	0e5cc77aaa73ceb791f8be7456177577fd2e5586
ToppCell	CV-Healthy-7\|Healthy / Virus stimulation, Condition and Cluster	MMS22L POLA1 DOCK9 ZNF829 ZNF681	2.80e-05	185	85	5	1979d189c204f4c2893e3170a514ee7d5523406c
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-Mono-Mono_anti-infl-A\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ADPRM DGAT2 POLA1 DAPK1 MAPKBP1	3.18e-05	190	85	5	63018acb7ad80415e861643162abdc2e55968ee4
ToppCell	pdx-Tumor_cells-T1\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	PDS5B MMS22L POLA1 CENPU DNA2	3.18e-05	190	85	5	d06ee5f89f1cec8db6897fe3b2a890a07cd3697b
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	STARD13 PDS5B FAP MCC CBLB	3.26e-05	191	85	5	1caf726bd07fdca389e678fc16304a6ef1790423
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	STARD13 PDS5B FAP MCC CBLB	3.26e-05	191	85	5	3d60c46bced2984c27a1fcf2910bc38b31fb0148
Disease	diabetes mellitus	TLE1 PAM IDE RREB1	2.92e-05	68	76	4	EFO_0000400
Disease	xeroderma pigmentosum (is_implicated_in)	ERCC4 XPA	9.75e-05	6	76	2	DOID:0050427 (is_implicated_in)
Disease	Autism spectrum disorder	PTCHD1 TBR1	1.36e-04	7	76	2	cv:C1510586
Disease	Xeroderma pigmentosum	ERCC4 XPA	2.33e-04	9	76	2	cv:C0043346
Disease	Basal cell carcinoma	ERCC4 XPA	3.55e-04	11	76	2	C0007117
Disease	non-alcoholic fatty liver disease (biomarker_via_orthology)	DGAT2 HPR IDE	6.39e-04	65	76	3	DOID:0080208 (biomarker_via_orthology)
Disease	intellectual disability (implicated_via_orthology)	CUL4B CAPN8 UBR4	9.70e-04	75	76	3	DOID:1059 (implicated_via_orthology)
Disease	mental or behavioural disorder	VPS13C MCC DAPK1 POU3F4	1.20e-03	179	76	4	EFO_0000677
Disease	ovarian carcinoma	PTCHD1 MMS22L TLE1 DAPK1 NCAM2	1.45e-03	321	76	5	EFO_0001075
Disease	Seckel syndrome	RBBP8 DNA2	1.46e-03	22	76	2	C0265202
Disease	visceral adipose tissue measurement, body mass index	TLE1 PCDHAC2 RREB1	1.49e-03	87	76	3	EFO_0004340, EFO_0004765
Disease	lipid measurement, lipoprotein measurement	DGAT2 HPR LDLR	1.64e-03	90	76	3	EFO_0004529, EFO_0004732
Disease	Micronuclei, Chromosome-Defective	ERCC4 XPA	2.04e-03	26	76	2	C1449861
Disease	Micronuclei, Genotoxicant-Induced	ERCC4 XPA	2.04e-03	26	76	2	C1449862
Disease	antipsychotic drug related weight gain	CBLB ZNF883	2.20e-03	27	76	2	EFO_0004567
Disease	cognitive function measurement, self reported educational attainment	MMS22L PAM EIF3C BANK1 EIF3CL	2.25e-03	355	76	5	EFO_0004784, EFO_0008354
Disease	chronic kidney disease (biomarker_via_orthology)	DGAT2 HPR	2.37e-03	28	76	2	DOID:784 (biomarker_via_orthology)
Disease	Neoplasm Metastasis	ERCC4 SLC39A6 DAPK1 LECT2	2.41e-03	217	76	4	C0027627
Disease	serum gamma-glutamyl transferase measurement	ZZZ3 NUAK1 HPR GLIS3 MCC FUT3 RREB1 CBLB	2.42e-03	914	76	8	EFO_0004532

Protein segments in the cluster

Peptide	Gene	Start	Entry
PEEENVYNKLTIVHH	BANK1	731	Q8NDB2
IQHPNVITLHEVYEN	DAPK1	71	P53355
NPHVRYIEQTHTKLE	RBBP8	181	Q99708
PEFEKTHLEHQQRIE	CENPU	256	Q71F23
REDVVHVHKYNPTEK	PAM	401	P19021
LNTKFLEDQIVHHPE	ADPRM	126	Q3LIE5
YPDQKENTHFTVLIH	CHI3L2	146	Q15782
YQVPKELESHTDAHL	CAPN8	436	A6NHC0
IHLLAHDPDYVKVQD	PDS5B	996	Q9NTI5
PHIVHFQYEVTEVKV	OAZ2	76	O95190
PGYTQEEKIEIAHRH	LONP2	511	Q86WA8
KVQNAESHVPVHPYE	MMS22L	146	Q6ZRQ5
QLVEIEKVVLHPNYH	HPR	171	P00739
EKVVLHPNYHQVDIG	HPR	176	P00739
HPNIVKLHEVYETDM	DCLK3	411	Q9C098
EPTPHDHIKVTQEQY	CBLB	346	Q13191
EVTKAQEYLVHVAPH	LENG9	336	Q96B70
EDPFNIHDLKVNVEH	PFKL	596	P17858
LQKVYPGIQSHVHIE	LECT2	126	O14960
AHTEYPVNTIIIHED	PRSS54	106	Q6PEW0
VLQHIEATPKIVHYA	GREB1L	1651	Q9C091
VHKIDPDIIVGHNIY	POLA1	626	P09884
ELADHVTVHKNEPYE	PEG3	1296	Q9GZU2
DQQPHEVYSHTVKTD	POU3F4	341	P49335
LIKEDVYLSHDHNIP	PTK6	336	Q13882
NVYVVDMNDHAPHIL	PCDHAC2	566	Q9Y5I4
NTDPHSQEYVEHLKD	EIF3C	461	Q99613
VENPQTHEVLHYVEK	GMPPA	156	Q96IJ6
QNTDPHSQEYVEHLK	EIF3CL	461	B5ME19
QEQAYLVHIEHLKSE	MCC	656	P23508
VLHHHQNPEFYDEIK	DOCK9	701	Q9BZ29
YDQQEELVRHIEKVH	GLIS3	356	Q8NEA6
VAEHSQVAELQEHKY	MAPKBP1	121	O60336
EERHQPVHYDSIKII	DUS4L	191	O95620
HPFQEEHLKQLYKIV	IDE	291	P14735
KVEEAHYITTHEIQL	C4orf54	361	D6RIA3
IEEETQHLKQTHLEY	DNA2	426	P51530
PEYLHHVNKRLEEEA	CUL4B	411	Q13620
KLEHPTQQDIDLYHT	DGAT2	346	Q96PD7
DRKVYPQADTVIVHH	FUT3	96	P21217
HVIYDVSHNIAKVEQ	RTCB	346	Q9Y3I0
EFHSQENLVVHIPKD	STARD13	386	Q9Y3M8
IHILDKQDHQYVIEI	TDRD6	631	O60522
HKYQPRLHVVEVNED	TBR1	331	Q16650
YQVEESVEHLLAPQH	PTCHD1	46	Q96NR3
PHIEEQQKKIESYLH	TENT5D	271	Q8NEK8
LEKHEIQPYEIALVH	RMND1	251	Q9NWS8
NHPHIISIYEVFENK	NUAK1	111	O60285
EVMIAHAHPQEVYNE	SLC39A6	516	Q13433
ISHYHINLDETQVPK	ANKRD20A12P	126	Q8NF67
EQIVTLYDDEQHPVH	RNF17	1596	Q9BXT8
VEHNAYGEIIQHELK	SMURF2	551	Q9HAU4
HIHYIKDTVENAIQI	FAP	376	Q12884
VEVLHVNKPDKYQLH	TLE1	681	Q04724
PIHHYQVDVKEVASE	NCAM2	526	O15394
YALVVHHPQDEVQVT	TMEM143	176	Q96AN5
KQHLHVPEQDIESYV	RREB1	811	Q92766
HFLIEKHDEVTPNEI	TERB2	111	Q8NHR7
HKHQVFDYPQVLQEA	EXT2	301	Q93063
NLIQHQKVHSEERPY	ZNF211	271	Q13398
EVQPKTHHRAHYETE	NFATC3	436	Q12968
ELVHHYQEAQLEPFK	SH2D7	121	A6NKC9
VLQYRSEDIHVKHPA	VPS13C	2781	Q709C8
ELIQHQRIHTDEKPY	ZNF829	366	Q3KNS6
SNVEVLHHTKPDKYQ	TLE3	681	Q04726
PKNEEFVLHLQSHEA	ZNF200	346	P98182
KRETIVHQHEYGPEE	XPA	236	P23025
HEALKENGVTHPIDY	VAT1	226	Q99536
THKETQPVYERAVHD	ZNF75D	191	P51815
LVDHQRIHTGEKPYQ	ZNF445	696	P59923
LVQHQRIHTGEKPYE	ZNF570	261	Q96NI8
NLTEHKNIHTEEKPY	ZNF681	436	Q96N22
FATHEIIHTIEKPYE	ZNF566	186	Q969W8
HNIKIYHLPDAESDE	SEPTIN2	206	Q15019
LVQHQRIHTGEKPYE	ZNF286B	426	P0CG31
LVQHQRIHTGEKPYE	ZNF883	56	P0CG24
NSFLEQHKPEVVEIH	ERCC4	201	Q92889
VEFRNHLKEQHPDIE	ZNF407	1786	Q9C0G0
VIESESEILHHEKQY	UBR4	56	Q5T4S7
DIHKEDHQLEPIYRS	ZZZ3	861	Q8IYH5
HNYKVVVTVHGEIDP	PTS	51	Q03393
HEDLNRVHEKPYVEL	USP6	636	P35125
LVQHQRIHSGEKPYE	ZNF134	191	P52741
VVQHQKIHTGERPYE	ZNF17	261	P17021
DPLQYKKHTLQHEEI	ZNF518B	146	Q9C0D4
PVYQKTTEDEVHICH	LDLR	826	P01130