Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionphosphatase binding

DTNA DTNB

1.03e-0326442GO:0019902
GeneOntologyCellularComponentside of membrane

ADAM21 DTNA

9.93e-0387542GO:0098552
GeneOntologyCellularComponentaxon

ADAM21 DTNA

1.03e-0289142GO:0030424
DomainDistrobrevin

DTNA DTNB

3.44e-08242IPR017432
DomainEF-hand_2

DTNA DTNB

5.16e-07642PF09068
DomainEF-hand_3

DTNA DTNB

5.16e-07642PF09069
DomainEF-hand_dom_typ1

DTNA DTNB

5.16e-07642IPR015153
DomainEF-hand_dom_typ2

DTNA DTNB

5.16e-07642IPR015154
DomainZZ

DTNA DTNB

5.26e-061842PF00569
DomainZF_ZZ_1

DTNA DTNB

5.26e-061842PS01357
DomainZF_ZZ_2

DTNA DTNB

5.26e-061842PS50135
DomainZnf_ZZ

DTNA DTNB

5.88e-061942IPR000433
DomainZnF_ZZ

DTNA DTNB

5.88e-061942SM00291
Domain-

DTNA DTNB

1.15e-03261421.10.238.10
DomainEF-hand-dom_pair

DTNA DTNB

1.38e-0328742IPR011992
Pubmed

Muscular dystrophies and the dystrophin-glycoprotein complex.

DTNA DTNB

9.92e-092429146999
Pubmed

Dysbindin, a novel coiled-coil-containing protein that interacts with the dystrobrevins in muscle and brain.

DTNA DTNB

2.98e-0834211316798
Pubmed

beta-dystrobrevin, a member of the dystrophin-related protein family.

DTNA DTNB

2.98e-083429419360
Pubmed

Molecular basis of dystrobrevin interaction with kinesin heavy chain: structural determinants of their binding.

DTNA DTNB

2.98e-0834216288919
Pubmed

Cerebellar synaptic defects and abnormal motor behavior in mice lacking alpha- and beta-dystrobrevin.

DTNA DTNB

2.98e-0834216540561
Pubmed

Biglycan regulates the expression and sarcolemmal localization of dystrobrevin, syntrophin, and nNOS.

DTNA DTNB

5.95e-0844216807372
Pubmed

DAMAGE, a novel alpha-dystrobrevin-associated MAGE protein in dystrophin complexes.

DTNA DTNB

5.95e-0844214623885
Pubmed

Myospryn is a novel binding partner for dysbindin in muscle.

DTNA DTNB

1.49e-0764214688250
Pubmed

Different dystrophin-like complexes are expressed in neurons and glia.

DTNA DTNB

1.49e-0764210545507
Pubmed

MLC1 trafficking and membrane expression in astrocytes: role of caveolin-1 and phosphorylation.

DTNA DTNB

2.08e-0774219931615
Pubmed

Reinvestigation of the dysbindin subunit of BLOC-1 (biogenesis of lysosome-related organelles complex-1) as a dystrobrevin-binding protein.

DTNA DTNB

2.08e-0774216448387
Pubmed

Gamma1- and gamma2-syntrophins, two novel dystrophin-binding proteins localized in neuronal cells.

DTNA DTNB

2.08e-0774210747910
Pubmed

Alpha-dystrobrevin-1 recruits alpha-catulin to the alpha1D-adrenergic receptor/dystrophin-associated protein complex signalosome.

DTNA DTNB

2.08e-0774221115837
Pubmed

Absence of alpha-syntrophin leads to structurally aberrant neuromuscular synapses deficient in utrophin.

DTNA DTNB

5.45e-07114210995443
Pubmed

gamma-Syntrophin scaffolding is spatially and functionally distinct from that of the alpha/beta syntrophins.

DTNA DTNB

5.45e-07114216857187
Pubmed

Blood pressure is regulated by an alpha1D-adrenergic receptor/dystrophin signalosome.

DTNA DTNB

3.48e-06274218468998
InteractionTAGAP interactions

DTNA DTNB

5.05e-061942int:TAGAP
InteractionSPZ1 interactions

DTNA DTNB

6.20e-062142int:SPZ1
InteractionMLC1 interactions

DTNA DTNB

8.14e-062442int:MLC1
InteractionSNTG2 interactions

DTNA DTNB

9.59e-062642int:SNTG2
InteractionSNTG1 interactions

DTNA DTNB

1.46e-053242int:SNTG1
InteractionSNTB1 interactions

DTNA DTNB

5.75e-056342int:SNTB1
InteractionKCNA4 interactions

DTNA DTNB

6.70e-056842int:KCNA4
InteractionMARK1 interactions

DTNA DTNB

7.94e-057442int:MARK1
InteractionPLEKHA2 interactions

DTNA DTNB

1.28e-049442int:PLEKHA2
InteractionFAM167A interactions

DTNA DTNB

1.34e-049642int:FAM167A
InteractionDTNB interactions

DTNA DTNB

1.48e-0410142int:DTNB
InteractionFYCO1 interactions

DTNA DTNB

1.54e-0410342int:FYCO1
InteractionSNTA1 interactions

DTNA DTNB

1.60e-0410542int:SNTA1
InteractionDTNA interactions

DTNA DTNB

2.27e-0412542int:DTNA
InteractionDMD interactions

DTNA DTNB

2.89e-0414142int:DMD
InteractionSNTB2 interactions

DTNA DTNB

2.97e-0414342int:SNTB2
InteractionDTNBP1 interactions

DTNA DTNB

3.81e-0416242int:DTNBP1
InteractionSGF29 interactions

DTNA DTNB

3.91e-0416442int:SGF29
InteractionCOG6 interactions

DTNA DTNB

3.91e-0416442int:COG6
InteractionINSYN1 interactions

DTNA DTNB

4.15e-0416942int:INSYN1
InteractionZGPAT interactions

DTNA DTNB

4.50e-0417642int:ZGPAT
InteractionUTRN interactions

DTNA DTNB

6.83e-0421742int:UTRN
InteractionCASK interactions

DTNA DTNB

7.08e-0422142int:CASK
InteractionTNS2 interactions

DTNA DTNB

8.00e-0423542int:TNS2
InteractionHMG20A interactions

DTNA DTNB

8.62e-0424442int:HMG20A
InteractionMARK3 interactions

DTNA DTNB

8.76e-0424642int:MARK3
InteractionNUP62 interactions

DTNA DTNB

1.08e-0327342int:NUP62
InteractionMARK2 interactions

DTNA DTNB

1.09e-0327442int:MARK2
InteractionCARM1 interactions

DTNA DTNB

1.52e-0332542int:CARM1
InteractionH1-5 interactions

DTNA DTNB

3.06e-0346342int:H1-5
InteractionFLOT1 interactions

DTNA DTNB

3.22e-0347542int:FLOT1
GeneFamilyZinc fingers ZZ-type|Lysine acetyltransferases

DTNA DTNB

5.61e-06184291
CoexpressionGSE20727_ROS_INH_VS_ROS_INH_AND_DNFB_ALLERGEN_TREATED_DC_DN

ADAM21 DTNA

3.31e-0419642M9248
CoexpressionGSE29949_DC_BRAIN_VS_MONOCYTE_BONE_MARROW_DN

ADAM21 DTNB

3.37e-0419842M8419
CoexpressionGSE17721_LPS_VS_CPG_24H_BMDC_UP

ZNF142 DTNB

3.41e-0419942M4010
CoexpressionGSE27786_LSK_VS_LIN_NEG_CELL_DN

ZNF142 DTNA

3.44e-0420042M4742
CoexpressionMILI_PSEUDOPODIA_HAPTOTAXIS_DN

ZNF142 DTNA

3.91e-0368142M5314
CoexpressionMILI_PSEUDOPODIA_HAPTOTAXIS_DN

ZNF142 DTNA

4.16e-0370342MM1055
ToppCell343B-Myeloid-Macrophage-SPP1+_Macrophage_2|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

ZNF142 DTNB

6.60e-0515042744050a1b665c6989f37141348af3df7579a73c9
ToppCellTCGA-Endometrium-Primary_Tumor-Endometrial_Adenocarcinoma-Serous_adenocarcinoma-5|TCGA-Endometrium / Sample_Type by Project: Shred V9

ADAM21 DTNA

7.23e-051574259450e9f580555091b159fbbe0a0756e51bcd9ad
Drugbromoacetylcholamine

DTNA DTNB

2.31e-08242CID000192097
DrugDTNP

DTNA DTNB

3.47e-07642CID000016474
DrugC11122

DTNA DTNB

2.43e-061542CID000119498
Drugthiocholine

DTNA DTNB

3.54e-061842CID000012234
Drugacetylthiocholine

DTNA DTNB

9.38e-062942CID000020544
Drug2-nitrobenzoate

DTNA DTNB

1.37e-053542CID000011087
DrugMoldin

DTNA DTNB

2.83e-055042CID000026331
DrugNL-4

ADAM21 DTNB

3.55e-055642CID016074496
DrugAC1LASJR

DTNA DTNB

4.08e-056042CID000474231
Drug2,2'-dithiodipyridine

DTNA DTNB

4.36e-056242CID000065093
DrugCPDS

DTNA DTNB

5.25e-056842CID000085040
Druglead arsenate

DTNA DTNB

9.02e-058942CID000024572
DrugDAPs

DTNA DTNB

9.64e-059242CID000146339
DrugDithiol

DTNA DTNB

1.14e-0410042CID000010334
DrugPCMBS

DTNA DTNB

1.26e-0410542CID000011136
Drug2-nitroimidazole

DTNA DTNB

1.90e-0412942CID000010701
Drugdithionite

DTNA DTNB

2.56e-0415042CID000001086
Drug5,5'-dithiobis(2-nitrobenzoic acid

DTNA DTNB

2.81e-0415742CID000006254
Drugdiphenylamine-2-carboxylate

DTNA DTNB

3.06e-0416442CID000004386
DrugDanazol [17230-88-5]; Down 200; 11.8uM; HL60; HG-U133A

ZNF142 DTNA

4.15e-04191422038_DN
DrugNimodipine [66085-59-4]; Up 200; 9.6uM; MCF7; HT_HG-U133A

DTNA DTNB

4.24e-04193425421_UP
DrugDNA-PK Inhibitor III; Up 200; 1uM; MCF7; HT_HG-U133A

DTNA DTNB

4.29e-04194427543_UP
DrugDipyrone [5907-38-0]; Up 200; 12uM; PC3; HT_HG-U133A

DTNA DTNB

4.29e-04194424310_UP
DrugClopamide [636-54-4]; Down 200; 11.6uM; HL60; HG-U133A

ZNF142 DTNA

4.33e-04195421605_DN
DrugChicago sky blue 6B [2610-05-1]; Up 200; 4uM; PC3; HT_HG-U133A

DTNA DTNB

4.33e-04195426626_UP
DrugNafronyl oxalate [3200-06-4]; Down 200; 8.4uM; HL60; HT_HG-U133A

ZNF142 DTNA

4.33e-04195421267_DN
DrugChicago sky blue 6B [2610-05-1]; Down 200; 4uM; HL60; HT_HG-U133A

ZNF142 DTNA

4.33e-04195421330_DN
DrugAtractyloside potassium salt [102130-43-8]; Up 200; 5uM; MCF7; HT_HG-U133A

DTNA DTNB

4.37e-04196423435_UP
DrugAcacetin [480-44-4]; Up 200; 14uM; PC3; HT_HG-U133A

DTNA DTNB

4.37e-04196424324_UP
DrugMegestrol acetate [595-33-5]; Up 200; 10.4uM; PC3; HT_HG-U133A

DTNA DTNB

4.37e-04196426667_UP
Drug(-)-Isoproterenol hydrochloride [5984-95-2]; Up 200; 16.2uM; MCF7; HT_HG-U133A

DTNA DTNB

4.37e-04196423571_UP
Drugcox-2 inhibitor I; Down 200; 10uM; MCF7; HG-U133A

ZNF142 DTNA

4.37e-0419642253_DN
DrugSulfanilamide [63-74-1]; Up 200; 23.2uM; MCF7; HT_HG-U133A

DTNA DTNB

4.37e-04196426810_UP
DrugAmyleine hydrochloride [532-59-2]; Up 200; 14.8uM; MCF7; HT_HG-U133A

DTNA DTNB

4.37e-04196424169_UP
DrugMefenamic acid [61-68-7]; Down 200; 16.6uM; HL60; HT_HG-U133A

ZNF142 DTNA

4.42e-04197421863_DN
DrugVigabatrin [60643-86-9]; Down 200; 31uM; HL60; HT_HG-U133A

ZNF142 DTNA

4.42e-04197422452_DN
DrugHydroxyzine dihydrochloride [2192-20-3]; Down 200; 9uM; PC3; HG-U133A

ZNF142 DTNA

4.42e-04197421941_DN
DrugPropranolol hydrochloride [318-98-9]; Up 200; 13.6uM; PC3; HT_HG-U133A

DTNA DTNB

4.42e-04197426759_UP
DrugCotinine (-) [486-56-6]; Down 200; 22.6uM; HL60; HG-U133A

ZNF142 DTNA

4.42e-04197422011_DN
DrugAzathioprine [446-86-6]; Up 200; 14.4uM; MCF7; HT_HG-U133A

DTNA DTNB

4.42e-04197425262_UP
DrugGuanabenz acetate [23256-50-0]; Down 200; 13.8uM; PC3; HT_HG-U133A

DTNA DTNB

4.42e-04197424642_DN
DrugFluphenazine dihydrochloride [146-56-5]; Down 200; 7.8uM; HL60; HG-U133A

ZNF142 DTNA

4.42e-04197421577_DN
DrugTetramisole hydrochloride [16595-80-5]; Up 200; 16.6uM; PC3; HT_HG-U133A

DTNA DTNB

4.42e-04197424587_UP
DrugAdiphenine hydrochloride [50-42-0]; Down 200; 11.4uM; MCF7; HT_HG-U133A

ZNF142 DTNA

4.42e-04197427037_DN
DrugAcyclovir [59277-89-3]; Up 200; 17.8uM; MCF7; HT_HG-U133A

DTNA DTNB

4.42e-04197425643_UP
DrugProstaglandin E1; Down 200; 10uM; MCF7; HT_HG-U133A

DTNA DTNB

4.46e-04198426576_DN
DrugCGX 0596987; Up 200; 20uM; PC3; HT_HG-U133A

DTNA DTNB

4.46e-04198426369_UP
DrugFursultiamine Hydrochloride [2105-43-3]; Up 200; 9.2uM; MCF7; HT_HG-U133A

DTNA DTNB

4.46e-04198427349_UP
DrugKawain [500-64-1]; Down 200; 17.4uM; HL60; HT_HG-U133A

ZNF142 DTNA

4.46e-04198422337_DN
DrugPhentolamine hydrochloride [73-05-2]; Down 200; 12.6uM; HL60; HT_HG-U133A

ZNF142 DTNA

4.46e-04198422362_DN
DrugAmiloride hydrochloride dihydrate [17440-83-4]; Down 200; 13.2uM; HL60; HG-U133A

ZNF142 DTNA

4.46e-04198421970_DN
Drugpioglitazone HCl; Down 200; 10uM; MCF7; HT_HG-U133A

DTNA DTNB

4.46e-04198427506_DN
DrugAzacyclonol [115-46-8]; Down 200; 15uM; HL60; HG-U133A

ZNF142 DTNA

4.46e-04198422020_DN
DrugPepstatin A [26305-03-3]; Down 200; 5.8uM; HL60; HT_HG-U133A

ZNF142 DTNA

4.46e-04198421328_DN
DrugSotalol hydrochloride [959-24-0]; Up 200; 13uM; PC3; HT_HG-U133A

DTNA DTNB

4.46e-04198424079_UP
DrugPhenelzine sulfate [156-51-4]; Up 200; 17uM; PC3; HT_HG-U133A

DTNA DTNB

4.46e-04198423802_UP
Drugsplitomicin; Down 200; 20uM; PC3; HG-U133A

ZNF142 DTNA

4.46e-0419842661_DN
DrugCP-863187 [668981-07-5]; Down 200; 10uM; MCF7; HT_HG-U133A

DTNA DTNB

4.46e-04198427508_DN
DrugThioperamide maleate [106243-16-7]; Up 200; 9.8uM; MCF7; HT_HG-U133A

DTNA DTNB

4.46e-04198425635_UP
DrugRiluzole hydrochloride; Down 200; 14.8uM; HL60; HT_HG-U133A

ZNF142 DTNA

4.46e-04198422334_DN
DrugAminophylline [317-34-0]; Up 200; 9.6uM; MCF7; HT_HG-U133A

DTNA DTNB

4.51e-04199425395_UP
Drugtolbutamide; Up 200; 100uM; MCF7; HG-U133A

ZNF142 DTNA

4.51e-0419942142_UP
Drug0317956-0000 [391210-11-0]; Up 200; 1uM; PC3; HT_HG-U133A

DTNA DTNB

4.51e-04199423777_UP
Drugmonastrol; Down 200; 100uM; PC3; HG-U133A

ZNF142 DTNA

4.51e-0419942668_DN
Drugcolchicine; Up 200; 0.1uM; MCF7; HG-U133A

ZNF142 DTNA

4.55e-0420042644_UP
DrugClidinium bromide [3485-62-9]; Up 200; 9.2uM; MCF7; HT_HG-U133A

DTNA DTNB

4.55e-04200426837_UP
Drugestradiol, USP; Down 200; 0.01uM; PC3; HG-U133A

ZNF142 DTNA

4.55e-0420042665_DN
DrugLabetalol hydrochloride [32780-64-6]; Up 200; 11uM; MCF7; HT_HG-U133A

DTNA DTNB

4.55e-04200423167_UP
DiseaseDuchenne muscular dystrophy (implicated_via_orthology)

DTNA DTNB

8.67e-063642DOID:11723 (implicated_via_orthology)
DiseaseS-6-hydroxywarfarin measurement

ADAM21 DTNA

9.15e-0436842EFO_0803326

Protein segments in the cluster

PeptideGeneStartEntry
YCYQKRCNNHDQHCR

ADAM21

501

Q9UKJ8
YRCQQCHNYQLCQNC

DTNB

256

O60941
YRCQQCHNYQLCQDC

DTNA

256

Q9Y4J8
QCNQCSYRCHRADQL

ZNF142

486

P52746