Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	storage vacuole	ARHGEF7 VAMP2	1.22e-04	4	95	2	GO:0000322
GeneOntologyCellularComponent	presynaptic active zone cytoplasmic component	UNC13B GUCY1B1 CTNNB1	1.51e-04	23	95	3	GO:0098831
GeneOntologyCellularComponent	transferase complex	KANSL3 UBR1 UBR2 PRAMEF7 PHF20 PIK3C2A POLG RNF19B SPTLC1 DEPDC5 ARIH1 PRAMEF8 IKBKB	4.08e-04	963	95	13	GO:1990234
GeneOntologyCellularComponent	intracellular protein-containing complex	KANSL3 UBR1 UBR2 PRAMEF7 KIF23 AGO4 PHF20 POLG RNF19B DEPDC5 CTNNB1 ARIH1 PRAMEF8	4.46e-04	972	95	13	GO:0140535
GeneOntologyCellularComponent	microtubule associated complex	KIF23 KIF15 DNAH17 TRIM54 RP1	8.45e-04	161	95	5	GO:0005875
GeneOntologyCellularComponent	terminal bouton	UNC13B GRIP1 POLG GRIK5	9.66e-04	96	95	4	GO:0043195
GeneOntologyCellularComponent	NSL complex	KANSL3 PHF20	1.09e-03	11	95	2	GO:0044545
GeneOntologyCellularComponent	cell cortex region	UNC13B GUCY1B1 CTNNB1	1.12e-03	45	95	3	GO:0099738
GeneOntologyCellularComponent	ubiquitin ligase complex	UBR1 UBR2 PRAMEF7 RNF19B DEPDC5 ARIH1 PRAMEF8	1.12e-03	352	95	7	GO:0000151
GeneOntologyCellularComponent	Cul2-RING ubiquitin ligase complex	PRAMEF7 ARIH1 PRAMEF8	1.28e-03	47	95	3	GO:0031462
GeneOntologyCellularComponent	synaptic membrane	UNC13B GRIP1 DLGAP1 IQSEC3 IL31RA KCND2 SYNE1 GRIK5 CTNNB1	1.34e-03	583	95	9	GO:0097060
GeneOntologyCellularComponent	cell cortex	UNC13B GRIP1 GUCY1B1 ARHGEF7 CTNNB1 FMNL1 EPB42	1.52e-03	371	95	7	GO:0005938
Domain	ClpS_core	UBR1 UBR2	2.35e-05	2	91	2	IPR003769
Domain	ClpS	UBR1 UBR2	2.35e-05	2	91	2	PF02617
Domain	-	UBR1 UBR2 BPTF PHF20 TRIM9 RNF19B VPS8 TRIM54 ARIH1 SP140	6.59e-05	449	91	10	3.30.40.10
Domain	Ribosomal_L7/12_C/ClpS-like	UBR1 UBR2	7.02e-05	3	91	2	IPR014719
Domain	-	UBR1 UBR2	7.02e-05	3	91	2	3.30.1390.10
Domain	Znf_RING/FYVE/PHD	UBR1 UBR2 BPTF PHF20 TRIM9 RNF19B VPS8 TRIM54 ARIH1 SP140	7.91e-05	459	91	10	IPR013083
Domain	Synaptobrevin/VAMP	VAMP5 VAMP2	3.48e-04	6	91	2	IPR016444
Domain	ZF_UBR	UBR1 UBR2	4.85e-04	7	91	2	PS51157
Domain	zf-UBR	UBR1 UBR2	4.85e-04	7	91	2	PF02207
Domain	Znf_UBR	UBR1 UBR2	4.85e-04	7	91	2	IPR003126
Domain	ZnF_UBR1	UBR1 UBR2	4.85e-04	7	91	2	SM00396
Domain	ZF_RING_1	UBR1 UBR2 TRIM9 RNF19B VPS8 TRIM54 ARIH1	5.50e-04	291	91	7	PS00518
Domain	ZF_RING_2	UBR1 UBR2 TRIM9 RNF19B VPS8 TRIM54 ARIH1	6.33e-04	298	91	7	PS50089
Domain	SYNAPTOBREVIN	VAMP5 VAMP2	6.45e-04	8	91	2	PS00417
Domain	-	VAMP5 VAMP2	6.45e-04	8	91	2	1.10.3840.10
Domain	MetalloPept_cat_dom	THOP1 MMEL1 ADAMTS20 ADAM29	6.59e-04	81	91	4	IPR024079
Domain	-	THOP1 MMEL1 ADAMTS20 ADAM29	6.59e-04	81	91	4	3.40.390.10
Domain	E3_UB_ligase_RBR	RNF19B ARIH1	1.03e-03	10	91	2	IPR031127
Domain	Znf_RING	UBR1 UBR2 TRIM9 RNF19B VPS8 TRIM54 ARIH1	1.07e-03	326	91	7	IPR001841
Domain	Synaptobrevin	VAMP5 VAMP2	1.25e-03	11	91	2	PF00957
Domain	ZINC_PROTEASE	THOP1 MMEL1 ADAMTS20 ADAM29	1.34e-03	98	91	4	PS00142
Domain	COS_domain	TRIM9 TRIM54	1.50e-03	12	91	2	IPR017903
Domain	COS	TRIM9 TRIM54	1.50e-03	12	91	2	PS51262
Domain	V_SNARE	VAMP5 VAMP2	1.50e-03	12	91	2	PS50892
Pubmed	Toll-like receptors 2, 4, and 9 modulate promoting effect of COPD-like airway inflammation on K-ras-driven lung cancer through activation of the MyD88/NF-ĸB pathway in the airway epithelium.	MYD88 TLR4 IKBKB	6.86e-07	7	95	3	37283745
Pubmed	The protein kinase PKR is required for macrophage apoptosis after activation of Toll-like receptor 4.	MYD88 TLR4 IKBKB	1.09e-06	8	95	3	15029200
Pubmed	Stimulation of TLR4 Attenuates Alzheimer's Disease-Related Symptoms and Pathology in Tau-Transgenic Mice.	MYD88 TLR4 IKBKB	1.09e-06	8	95	3	27605009
Pubmed	A20 prevents inflammasome-dependent arthritis by inhibiting macrophage necroptosis through its ZnF7 ubiquitin-binding domain.	MYD88 TLR4 IKBKB	3.21e-06	11	95	3	31086261
Pubmed	Commensal-driven immune zonation of the liver promotes host defence.	MYD88 TLR4 CTNNB1	5.54e-06	13	95	3	33239787
Pubmed	Resistin competes with lipopolysaccharide for binding to toll-like receptor 4.	RETN TLR4	7.38e-06	2	95	2	19754671
Pubmed	MyD88-TLR4-dependent choroid plexus activation precedes perilesional inflammation and secondary brain edema in a mouse model of intracerebral hemorrhage.	MYD88 TLR4	7.38e-06	2	95	2	36482445
Pubmed	IL-4-dependent Th2 collateral priming to inhaled antigens independent of Toll-like receptor 4 and myeloid differentiation factor 88.	MYD88 TLR4	7.38e-06	2	95	2	15034070
Pubmed	Bound Waters Mediate Binding of Diverse Substrates to a Ubiquitin Ligase.	UBR1 UBR2	7.38e-06	2	95	2	28392261
Pubmed	Microglial activation by Citrobacter koseri is mediated by TLR4- and MyD88-dependent pathways.	MYD88 TLR4	7.38e-06	2	95	2	19812209
Pubmed	Ischemia-reperfusion lung injury is attenuated in MyD88-deficient mice.	MYD88 TLR4	7.38e-06	2	95	2	24146959
Pubmed	[Effect of yiqi huoxue recipe containing drug-serum on the Toll-Iike receptor-4 and its downstream signaling components MyD88 as well as the tumor necrosis factor receptor related factor-6 in human vein endothelial cells].	MYD88 TLR4	7.38e-06	2	95	2	20681284
Pubmed	Atorvastatin attenuates TLR4-mediated NF-kappaB activation in a MyD88-dependent pathway.	MYD88 TLR4	7.38e-06	2	95	2	19548630
Pubmed	Inhibitory Effects of the Lactobacillus rhamnosus GG Effector Protein HM0539 on Inflammatory Response Through the TLR4/MyD88/NF-кB Axis.	MYD88 TLR4	7.38e-06	2	95	2	33123130
Pubmed	Toll-like receptor 4 and myeloid differentiation factor 88 are required for gastric bypass-induced metabolic effects.	MYD88 TLR4	7.38e-06	2	95	2	34462225
Pubmed	Upregulated expression of toll-like receptor 4 in monocytes correlates with severity of acute cerebral infarction.	MYD88 TLR4	7.38e-06	2	95	2	18523439
Pubmed	DNAJC12 promotes lung cancer growth by regulating the activation of β‑catenin.	DNAJC12 CTNNB1	7.38e-06	2	95	2	33907820
Pubmed	Role of N-end rule ubiquitin ligases UBR1 and UBR2 in regulating the leucine-mTOR signaling pathway.	UBR1 UBR2	7.38e-06	2	95	2	20298436
Pubmed	Toll-like receptor 4 prompts human breast cancer cells invasiveness via lipopolysaccharide stimulation and is overexpressed in patients with lymph node metastasis.	MYD88 TLR4	7.38e-06	2	95	2	25299052
Pubmed	Lys694Arg polymorphism leads to blunted responses to LPS by interfering TLR4 with recruitment of MyD88.	MYD88 TLR4	7.38e-06	2	95	2	32513051
Pubmed	TLR4 activation mediates kidney ischemia/reperfusion injury.	MYD88 TLR4	7.38e-06	2	95	2	17853945
Pubmed	TLR4-MyD88 pathway promotes the imbalanced activation of NLRP3/NLRP6 via caspase-8 stimulation after alkali burn injury.	MYD88 TLR4	7.38e-06	2	95	2	30008389
Pubmed	The acute exposure of tetrachloro-p-benzoquinone (a.k.a. chloranil) triggers inflammation and neurological dysfunction via Toll-like receptor 4 signaling: The protective role of melatonin preconditioning.	MYD88 TLR4	7.38e-06	2	95	2	28238930
Pubmed	Platycodin D inhibits MPP+-induced inflammatory response in BV-2 cells through the TLR4/MyD88/NF-κB signaling pathway.	MYD88 TLR4	7.38e-06	2	95	2	32429710
Pubmed	Lipoprotein accumulation in macrophages via toll-like receptor-4-dependent fluid phase uptake.	MYD88 TLR4	7.38e-06	2	95	2	19461045
Pubmed	Deficiency of UBR1, a ubiquitin ligase of the N-end rule pathway, causes pancreatic dysfunction, malformations and mental retardation (Johanson-Blizzard syndrome).	UBR1 UBR2	7.38e-06	2	95	2	16311597
Pubmed	Toll-like receptor-4 inhibits enterocyte proliferation via impaired beta-catenin signaling in necrotizing enterocolitis.	TLR4 CTNNB1	7.38e-06	2	95	2	19786028
Pubmed	IKKβ is a β-catenin kinase that regulates mesenchymal stem cell differentiation.	CTNNB1 IKBKB	7.38e-06	2	95	2	29367460
Pubmed	Cutting edge: FimH adhesin of type 1 fimbriae is a novel TLR4 ligand.	MYD88 TLR4	7.38e-06	2	95	2	18981086
Pubmed	Toll-like receptor 4-myeloid differentiation factor 88 signaling contributes to ventilator-induced lung injury in mice.	MYD88 TLR4	7.38e-06	2	95	2	20683250
Pubmed	The MyD88-independent pathway is not mobilized in human neutrophils stimulated via TLR4.	MYD88 TLR4	7.38e-06	2	95	2	17513785
Pubmed	Dioscin prevents LPS‑induced acute lung injury through inhibiting the TLR4/MyD88 signaling pathway via upregulation of HSP70.	MYD88 TLR4	7.38e-06	2	95	2	29512786
Pubmed	Evidence that tricyclic small molecules may possess toll-like receptor and myeloid differentiation protein 2 activity.	MYD88 TLR4	7.38e-06	2	95	2	20381591
Pubmed	The protective effects of S14G-humanin (HNG) against lipopolysaccharide (LPS)- induced inflammatory response in human dental pulp cells (hDPCs) mediated by the TLR4/MyD88/NF-κB pathway.	MYD88 TLR4	7.38e-06	2	95	2	34605740
Pubmed	Cellular responses to bacterial cell wall components are mediated through MyD88-dependent signaling cascades.	MYD88 TLR4	7.38e-06	2	95	2	10607756
Pubmed	TLR-dependent phagosome tubulation in dendritic cells promotes phagosome cross-talk to optimize MHC-II antigen presentation.	MYD88 TLR4	7.38e-06	2	95	2	25313083
Pubmed	High expression of Toll-like receptor 4/myeloid differentiation factor 88 signals correlates with poor prognosis in colorectal cancer.	MYD88 TLR4	7.38e-06	2	95	2	20145615
Pubmed	The TLR4-MyD88 Signaling Axis Regulates Lung Monocyte Differentiation Pathways in Response to Streptococcus pneumoniae.	MYD88 TLR4	7.38e-06	2	95	2	33042124
Pubmed	Glabridin attenuates atopic dermatitis progression through downregulating the TLR4/MyD88/NF-κB signaling pathway.	MYD88 TLR4	7.38e-06	2	95	2	34021857
Pubmed	Expression and significance of the TLR4/MyD88 signaling pathway in ovarian epithelial cancers.	MYD88 TLR4	7.38e-06	2	95	2	22985132
Pubmed	Nuclear factor translocation and acute anterior uveitis.	MYD88 TLR4	7.38e-06	2	95	2	21264236
Pubmed	The role of MyD88 and TLR4 in the LPS-mimetic activity of Taxol.	MYD88 TLR4	7.38e-06	2	95	2	11500829
Pubmed	The critical role of toll-like receptor (TLR) 4 in alcoholic liver disease is independent of the common TLR adapter MyD88.	MYD88 TLR4	7.38e-06	2	95	2	18792393
Pubmed	The MyD88+ phenotype is an adverse prognostic factor in epithelial ovarian cancer.	MYD88 TLR4	7.38e-06	2	95	2	24977712
Pubmed	Toll-like receptor-4 is required for intestinal response to epithelial injury and limiting bacterial translocation in a murine model of acute colitis.	MYD88 TLR4	7.38e-06	2	95	2	15826931
Pubmed	Heparan sulfate, an endogenous TLR4 agonist, promotes acute GVHD after allogeneic stem cell transplantation.	MYD88 TLR4	7.38e-06	2	95	2	22760779
Pubmed	Is serum amyloid A an endogenous TLR4 agonist?	MYD88 TLR4	7.38e-06	2	95	2	18252871
Pubmed	TLR4 signaling induced by lipopolysaccharide or paclitaxel regulates tumor survival and chemoresistance in ovarian cancer.	MYD88 TLR4	7.38e-06	2	95	2	19826413
Pubmed	Schistosome larvae stimulate macrophage cytokine production through TLR4-dependent and -independent pathways.	MYD88 TLR4	7.38e-06	2	95	2	16186163
Pubmed	Dendritic-cell function in Toll-like receptor- and MyD88-knockout mice.	MYD88 TLR4	7.38e-06	2	95	2	11286707
Pubmed	Positive Correlation between Enhanced Expression of TLR4/MyD88/NF-κB with Insulin Resistance in Placentae of Gestational Diabetes Mellitus.	MYD88 TLR4	7.38e-06	2	95	2	27340831
Pubmed	Concomitant inhalation of cigarette smoke and aerosolized protein activates airway dendritic cells and induces allergic airway inflammation in a TLR-independent way.	MYD88 TLR4	7.38e-06	2	95	2	19635922
Pubmed	Lipopolysaccharide stimulation of trophoblasts induces corticotropin-releasing hormone expression through MyD88.	MYD88 TLR4	7.38e-06	2	95	2	18771998
Pubmed	Disruption of membrane cholesterol stimulates MyD88-dependent NF-kappaB activation in immature B cells.	MYD88 TLR4	7.38e-06	2	95	2	15331330
Pubmed	A Novel 1,8-Naphthyridine-2-Carboxamide Derivative Attenuates Inflammatory Responses and Cell Migration in LPS-Treated BV2 Cells via the Suppression of ROS Generation and TLR4/Myd88/NF-κB Signaling Pathway.	MYD88 TLR4	7.38e-06	2	95	2	33802409
Pubmed	Long-term bezafibrate treatment improves skin and spleen phenotypes of the mtDNA mutator mouse.	POLG TLR4	7.38e-06	2	95	2	22962610
Pubmed	Chlamydial heat shock protein 60 induces acute pulmonary inflammation in mice via the Toll-like receptor 4- and MyD88-dependent pathway.	MYD88 TLR4	7.38e-06	2	95	2	19398543
Pubmed	Dioscin alleviates alcoholic liver fibrosis by attenuating hepatic stellate cell activation via the TLR4/MyD88/NF-κB signaling pathway.	MYD88 TLR4	7.38e-06	2	95	2	26655640
Pubmed	V gamma 4+ gamma delta T cells regulate airway hyperreactivity to methacholine in ovalbumin-sensitized and challenged mice.	MYD88 TLR4	7.38e-06	2	95	2	12960345
Pubmed	Toll-Like Receptor 4 Is an Essential Upstream Regulator of On-Time Parturition and Perinatal Viability in Mice.	MYD88 TLR4	7.38e-06	2	95	2	26151355
Pubmed	Zhikang Capsule ameliorates dextran sodium sulfate-induced colitis by inhibition of inflammation, apoptosis, oxidative stress and MyD88-dependent TLR4 signaling pathway.	MYD88 TLR4	7.38e-06	2	95	2	27452656
Pubmed	Adjuvant-mediated tumor regression and tumor-specific cytotoxic response are impaired in MyD88-deficient mice.	MYD88 TLR4	7.38e-06	2	95	2	14744795
Pubmed	Lipopolysaccharide stimulates platelet secretion and potentiates platelet aggregation via TLR4/MyD88 and the cGMP-dependent protein kinase pathway.	MYD88 TLR4	7.38e-06	2	95	2	19494325
Pubmed	Novel critical role of Toll-like receptor 4 in lung ischemia-reperfusion injury and edema.	MYD88 TLR4	7.38e-06	2	95	2	19376887
Pubmed	TLR4 Influences Hepatitis B Virus Related Hepatocellular Carcinoma by Regulating the Wnt/β-Catenin Pathway.	TLR4 CTNNB1	7.38e-06	2	95	2	28578348
Pubmed	Qing Hua Chang Yin exerts therapeutic effects against ulcerative colitis through the inhibition of the TLR4/NF-κB pathway.	MYD88 TLR4	7.38e-06	2	95	2	23900586
Pubmed	Regulative Loop between β-catenin and Protein Tyrosine Receptor Type γ in Chronic Myeloid Leukemia.	PTPRG CTNNB1	7.38e-06	2	95	2	32225105
Pubmed	Opioid activation of toll-like receptor 4 contributes to drug reinforcement.	MYD88 TLR4	7.38e-06	2	95	2	22895704
Pubmed	HBsAg/β2GPI activates the NF‑κB pathway via the TLR4/MyD88/IκBα axis in hepatocellular carcinoma.	MYD88 TLR4	7.38e-06	2	95	2	29916535
Pubmed	Impaired neurogenesis and cardiovascular development in mice lacking the E3 ubiquitin ligases UBR1 and UBR2 of the N-end rule pathway.	UBR1 UBR2	7.38e-06	2	95	2	16606826
Pubmed	Resistin inhibits neuronal autophagy through Toll-like receptor 4.	RETN TLR4	7.38e-06	2	95	2	29773580
Pubmed	Humoral immune response to flagellin requires T cells and activation of innate immunity.	MYD88 TLR4	7.38e-06	2	95	2	16920916
Pubmed	Resistin facilitates breast cancer progression via TLR4-mediated induction of mesenchymal phenotypes and stemness properties.	RETN TLR4	7.38e-06	2	95	2	28991224
Pubmed	TLR4/MyD88 signaling determines the metastatic potential of breast cancer cells.	MYD88 TLR4	7.38e-06	2	95	2	30066873
Pubmed	Maternal Neutrophil Depletion Fails to Avert Systemic Lipopolysaccharide-Induced Early Pregnancy Defects in Mice.	MYD88 TLR4	7.38e-06	2	95	2	34360700
Pubmed	Ursolic acid exhibits anti-inflammatory effects through blocking TLR4-MyD88 pathway mediated by autophagy.	MYD88 TLR4	7.38e-06	2	95	2	31302461
Pubmed	Low-intensity pulsed ultrasound (LIPUS) inhibits LPS-induced inflammatory responses of osteoblasts through TLR4-MyD88 dissociation.	MYD88 TLR4	7.38e-06	2	95	2	24091132
Pubmed	Human resistin protects against endotoxic shock by blocking LPS-TLR4 interaction.	RETN TLR4	7.38e-06	2	95	2	29133417
Pubmed	Methicillin-Resistant Staphylococcus Aureus infection exacerbates NSCLC cell metastasis by up-regulating TLR4/MyD88 pathway.	MYD88 TLR4	7.38e-06	2	95	2	27545207
Pubmed	Regulation of protein catabolism by muscle-specific and cytokine-inducible ubiquitin ligase E3alpha-II during cancer cachexia.	UBR1 UBR2	7.38e-06	2	95	2	15548684
Pubmed	MyD88 Signaling Accompanied by Microbiota Changes Supports Urinary Bladder Carcinogenesis.	MYD88 TLR4	7.38e-06	2	95	2	39000291
Pubmed	Aspirin-Triggered Lipoxin Protects Lipopolysaccharide-Induced Acute Kidney Injury via the TLR4/MyD88/NF-κB Pathway.	MYD88 TLR4	7.38e-06	2	95	2	33229758
Pubmed	Role of Bacillus anthracis spore structures in macrophage cytokine responses.	MYD88 TLR4	7.38e-06	2	95	2	17339355
Pubmed	Sepsis-induced organ failure is mediated by different pathways in the kidney and liver: acute renal failure is dependent on MyD88 but not renal cell apoptosis.	MYD88 TLR4	7.38e-06	2	95	2	16518342
Pubmed	Essential role for TLR4 and MyD88 in the development of chronic intestinal nematode infection.	MYD88 TLR4	7.38e-06	2	95	2	14579265
Pubmed	TLR4 activates the β-catenin pathway to cause intestinal neoplasia.	TLR4 CTNNB1	7.38e-06	2	95	2	23691015
Pubmed	Inhibiting the TLR4-MyD88 signalling cascade by genetic or pharmacological strategies reduces acute alcohol-induced sedation and motor impairment in mice.	MYD88 TLR4	7.38e-06	2	95	2	21955045
Pubmed	The Toll-receptor family and control of innate immunity.	MYD88 TLR4	7.38e-06	2	95	2	10047546
Pubmed	B cell receptor cross-talk: exposure to lipopolysaccharide induces an alternate pathway for B cell receptor-induced ERK phosphorylation and NF-kappa B activation.	MYD88 TLR4	7.38e-06	2	95	2	17579042
Pubmed	Role of progesterone in TLR4-MyD88-dependent signaling pathway in pre-eclampsia.	MYD88 TLR4	7.38e-06	2	95	2	24142728
Pubmed	Kinesin family member 23 knockdown inhibits cell proliferation and epithelial-mesenchymal transition in esophageal carcinoma by inactivating the Wnt/β-catenin pathway.	KIF23 CTNNB1	7.38e-06	2	95	2	37162618
Pubmed	Anti-inflammatory effects of royal poinciana through inhibition of toll-like receptor 4 signaling pathway.	MYD88 TLR4	7.38e-06	2	95	2	26971223
Pubmed	Toll-like receptor 4 deficiency causes pulmonary emphysema.	MYD88 TLR4	7.38e-06	2	95	2	17053835
Pubmed	Prognostic value of myeloid differentiation primary response 88 and Toll-like receptor 4 in breast cancer patients.	MYD88 TLR4	7.38e-06	2	95	2	25360699
Pubmed	Gliadin stimulation of murine macrophage inflammatory gene expression and intestinal permeability are MyD88-dependent: role of the innate immune response in Celiac disease.	MYD88 TLR4	7.38e-06	2	95	2	16456012
Pubmed	Melatonin modulates TLR4-mediated inflammatory genes through MyD88- and TRIF-dependent signaling pathways in lipopolysaccharide-stimulated RAW264.7 cells.	MYD88 TLR4	7.38e-06	2	95	2	22537289
Pubmed	Structural basis of substrate recognition and specificity in the N-end rule pathway.	UBR1 UBR2	7.38e-06	2	95	2	20835242
Pubmed	Immune activated monocyte exosomes alter microRNAs in brain endothelial cells and initiate an inflammatory response through the TLR4/MyD88 pathway.	MYD88 TLR4	7.38e-06	2	95	2	28855621
Pubmed	Toll-Like Receptor 4-Myeloid Differentiation Primary Response Gene 88 Pathway Is Involved in the Inflammatory Development of Polymyositis by Mediating Interferon-γ and Interleukin-17A in Humans and Experimental Autoimmune Myositis Mouse Model.	MYD88 TLR4	7.38e-06	2	95	2	28446897
Pubmed	Drosophila MyD88 is required for the response to fungal and Gram-positive bacterial infections.	MYD88 TLR4	7.38e-06	2	95	2	11743586
Interaction	CROCC interactions	UBR1 UBR2 SYNE1 CEP250 CTNNB1	7.32e-06	59	92	5	int:CROCC
GeneFamily	Ubiquitin protein ligase E3 component n-recognins	UBR1 UBR2	2.56e-04	7	64	2	785
GeneFamily	Vesicle associated membrane proteins	VAMP5 VAMP2	2.56e-04	7	64	2	12
Coexpression	MCCLUNG_COCAINE_REWARD_5D	KIF23 KRT16 KCND2 VAMP2 FMNL1	7.94e-06	75	95	5	MM658
Coexpression	MCCLUNG_COCAINE_REWARD_5D	KIF23 KRT16 KCND2 VAMP2 FMNL1	7.94e-06	75	95	5	M1539
ToppCell	Control-Epithelial_cells-AT2\|Control / group, cell type (main and fine annotations)	UNC13B DLGAP1 PTPRG NECAB1 SYNE1 CFAP221	2.44e-06	180	95	6	198b19e7910b4a8cc7e820c525ab357c7f99f578
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PTPRG CFAP221 DNAH17 RP1 PLEKHD1 BICD1	3.33e-06	190	95	6	1cf023e3c6924d6a06f353d4b62444b6f2fee8a7
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell-Ascending_Thin_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PTPRG CFAP221 DNAH17 RP1 PLEKHD1 BICD1	3.33e-06	190	95	6	59bbbd2c8d4b7ce46c54ca8022b1557e7e5eee2a
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Rorb-Excitatory_Neuron.Sc17a7.Rorb-Gpr83_(Layer_5a)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	MMEL1 CFAP221 TKTL2 C4orf54 MYBPC3	3.54e-06	108	95	5	5af010a1ee6535b144ccd16999c225508a4b3433
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	KIF23 ATP11B TRIM9 HMGCS1 RP1	2.46e-05	161	95	5	4bb7bae54ba3bdf46b525c01f5ad3db8e49819cb
ToppCell	facs-Diaphragm-Limb_Muscle-24m\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRANK1 OTOGL SPTLC1 MYH15 RP1	3.11e-05	169	95	5	12bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCell	Healthy-RBC\|Healthy / disease group, cell group and cell class	KIF23 KIF15 SLFN14 TKTL2 EPB42	3.87e-05	177	95	5	945d72ab52efa9a9468daace9f9ec676a891d963
ToppCell	Globus_pallidus-Neuronal-Inhibitory\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	GRIP1 IQSEC3 MMEL1 TCF25 PLEKHD1	4.42e-05	182	95	5	04ccfa951eaa31fed6d140edb6c702d49363c5fa
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DLGAP1 PTPRG SYNE1 CFAP221 RP1	4.91e-05	186	95	5	f0c8de4f6ae9047b9108a47a2af8c5f42bc103b0
ToppCell	pdx-Tumor_cells-T5\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	PIK3C2A SLC6A16 CFAP221 APLF BICD1	5.03e-05	187	95	5	7e376831a11ee72ed87abcdac631ca46ae29c250
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PTPRG CFAP221 DNAH17 RP1 BICD1	5.03e-05	187	95	5	c41a2c81dd2ceef303f39f699032aa7d6ea67cf0
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2-D122\|Adult / Lineage, Cell type, age group and donor	UNC13B PTPRG NECAB1 CFAP221 HMGCS1	5.70e-05	192	95	5	06013a07e3a873b1d1c0451643c528593ac32a9c
ToppCell	facs-Aorta-Heart-3m\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRRC8C UBR2 PTPRG SYNE1 CTNNB1	5.70e-05	192	95	5	1ccc47792edf9ee23501c8e2165d11271636b66a
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-AT2-AT2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	UNC13B PTPRG NECAB1 SYNE1 CFAP221	5.84e-05	193	95	5	fd4d3c0d7caf8a2fff5b3d901fc28d19a8163cdf
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.3\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	UNC13B NECAB1 SYNE1 CFAP221 RP1	5.84e-05	193	95	5	bdb7401dd9059032f930f2b575f2ef8e504b6594
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-AT2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	UNC13B PTPRG NECAB1 SYNE1 CFAP221	5.84e-05	193	95	5	f3cc7cfdbc164a4ed42f87647111522b7d393bcb
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	UNC13B PTPRG NECAB1 SYNE1 PACSIN2	5.99e-05	194	95	5	97534c8bba895a7913665e03ae4e5c4a6ad71daf
ToppCell	COVID-19-T_cells-Cycling_NK/T_cells\|COVID-19 / group, cell type (main and fine annotations)	KIF23 KIF15 CCDC73 APOLD1 EPB42	6.14e-05	195	95	5	764ed100c28d9bc93ee5ecabc5291c8f184d78da
ToppCell	CV-Moderate-6\|CV / Virus stimulation, Condition and Cluster	BPTF PHF20 VAMP2 ARIH1 FMNL1	6.29e-05	196	95	5	7bced0cc2112697593c478fa291b8ed3941fb811
ToppCell	3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	UNC13B NECAB1 SYNE1 HMGCS1 ARIH1	6.44e-05	197	95	5	bf10727fbe90b71d2ac60a11711e5f0701b3799d
ToppCell	Bronchial-NucSeq-Epithelial-Epi_alveolar-AT2\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	UNC13B PTPRG NECAB1 CFAP221 HMGCS1	6.60e-05	198	95	5	f948391296c261c473d339069a6d0f20ccd6f38f
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GRIP1 DLGAP1 KCND2 STRBP SYNE1	6.60e-05	198	95	5	4ca5ff320905ab4ff60ed90a5522227c782142a6
ToppCell	kidney_cells-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PTPRG PIK3C2A VAMP5 SYNE1 TLR4	6.75e-05	199	95	5	5d976d57872a8a25a11fe8cd53b01aa21a1a519a
ToppCell	5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.3.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	UNC13B PTPRG NECAB1 SYNE1 HMGCS1	6.75e-05	199	95	5	2dc33804f6691d7c9682e6c9b885e945fb97fc36
ToppCell	kidney_cells-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	APOLD1 PIK3C2A VAMP5 SYNE1 TLR4	6.75e-05	199	95	5	14e09eaa2335d4503de50250eb4258dd5b85b304
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	BPTF TUT4 AGO4 PTPRG PIK3C2A	6.92e-05	200	95	5	dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCell	LPS_only-Hematopoietic_Erythro-Megakary\|LPS_only / Treatment groups by lineage, cell group, cell type	KIF23 ATP11B KIF15 SLFN14 EPB42	6.92e-05	200	95	5	ce8281c9556a1f64f8ca8a029110077d4ef5b35e
ToppCell	kidney_cells-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	APOLD1 PIK3C2A VAMP5 SYNE1 TLR4	6.92e-05	200	95	5	3007583eaad3a5ae2df010513d3e4df59155123d
ToppCell	LPS_only-Hematopoietic_Erythro-Megakary-Erythro-Mega-Erythroid\|LPS_only / Treatment groups by lineage, cell group, cell type	KIF23 ATP11B KIF15 SLFN14 EPB42	6.92e-05	200	95	5	83c4181c083b364f0d3a89ae7a0504781fa9fa9f
ToppCell	LPS_only-Hematopoietic_Erythro-Megakary-Erythro-Mega\|LPS_only / Treatment groups by lineage, cell group, cell type	KIF23 ATP11B KIF15 SLFN14 EPB42	6.92e-05	200	95	5	f15baf287ec467664c23faa53fdea45257f7b9d0
Drug	CPG-oligonucleotide	MYD88 TRANK1 POLG POLH TLR4 ATXN3 INTS3 JMY	9.62e-07	184	94	8	ctd:C408982
Disease	cerebellar ataxia (is_implicated_in)	SYNE1 POLG	9.77e-05	5	93	2	DOID:0050753 (is_implicated_in)
Disease	unipolar depression, bipolar disorder	CCDC73 SYNE1 TLR4 MYH15 GRIK5	1.38e-04	156	93	5	EFO_0003761, MONDO_0004985
Disease	Eosinophilia, Tropical	MYD88 TLR4	2.04e-04	7	93	2	C0014458
Disease	Eosinophilia	MYD88 TLR4	2.72e-04	8	93	2	C0014457
Disease	Sudden Cardiac Arrest	KCND2 MYBPC3	2.72e-04	8	93	2	C1720824
Disease	Pneumonia	MYD88 TLR4 IKBKB	6.69e-04	54	93	3	C0032285
Disease	Lobar Pneumonia	MYD88 TLR4 IKBKB	6.69e-04	54	93	3	C0032300
Disease	Pneumonitis	MYD88 TLR4 IKBKB	6.69e-04	54	93	3	C3714636
Disease	Experimental Lung Inflammation	MYD88 TLR4 IKBKB	6.69e-04	54	93	3	C0887898
Disease	eosinophil percentage of granulocytes	KANSL3 UBR2 BPTF CYP21A2 SP140	8.86e-04	234	93	5	EFO_0007996
Disease	1-Methylhistidine measurement	KCND2 OTOGL	1.30e-03	17	93	2	EFO_0021543
Disease	colorectal cancer, inflammatory bowel disease	GRIK5 SP140	1.62e-03	19	93	2	EFO_0003767, MONDO_0005575
Disease	hepatitis B (is_marker_for)	MYD88 CTNNB1	1.98e-03	21	93	2	DOID:2043 (is_marker_for)
Disease	triacylglycerol 58:9 measurement	APOLD1 CYP21A2	2.18e-03	22	93	2	EFO_0010443
Disease	hypertrophic cardiomyopathy (is_implicated_in)	RETN MYBPC3	2.18e-03	22	93	2	DOID:11984 (is_implicated_in)
Disease	hepatocellular carcinoma (is_implicated_in)	MYD88 POLG TLR4 CTNNB1	2.61e-03	181	93	4	DOID:684 (is_implicated_in)
Disease	platelet component distribution width	TRANK1 VAMP5 SYNE1 CYP21A2 SLFN14 C4orf54 JMY PACSIN2	2.67e-03	755	93	8	EFO_0007984
Disease	coronary artery calcification	KCND2 TRIM9 ATXN3 ADAM29 ARL9 GRIK5	3.04e-03	450	93	6	EFO_0004723
Disease	anogenital venereal wart (is_marker_for)	MYD88 TLR4	3.04e-03	26	93	2	DOID:11168 (is_marker_for)

Protein segments in the cluster

Peptide	Gene	Start	Entry
DFEEVQRCTADMNIT	PTPRG	851	P23470
QAQVDEVVDIMRVNV	VAMP2	36	P63027
ITCRMEFEEIDNSTQ	ADAM29	171	Q9UKF5
LQRLTVEVDCNMFQN	EPB42	661	P16452
EVEMQCTLRNSQVLD	APLF	106	Q8IW19
RCDEYVTQLDEMQRQ	BICD1	751	Q96G01
VCINTEDSQMEFLEI	ARL9	56	Q6T311
TTKMENEECNEQRER	DNAJC12	121	Q9UKB3
VSEMEVNGQFESVCE	DLGAP1	451	O14490
EICSFQQMLVQSLEE	ARHGEF7	321	Q14155
IEFMCEVLDIQNINE	AGO4	221	Q9HCK5
AEREENQRMIVCNQV	BPTF	2686	Q12830
MECTDNQIRQVNEIV	ADAMTS20	1556	P59510
DREDINSLCMTVVQN	HMGCS1	61	Q01581
NVEEMFNCITELVLR	RAB35	156	Q15286
DTEAQCEVMQEIVDQ	INTS3	591	Q68E01
VREFVMQEAQQNDDV	PPP4R3A	396	Q6IN85
QHMVECIREVNEVIQ	ARIH1	111	Q9Y4X5
VQEIAATCQDQMREI	APOLD1	151	Q96LR9
EETQQVLMEERNVFC	FBXW10B	386	O95170
IAMVCQERSQNETYE	OVOS1	61	Q6IE37
VQMTAQQVFEEFICQ	DEPDC5	791	O75140
MAAVVRCQEQAQTTD	PLA2G12A	16	Q9BZM1
TQQQFVEGVRMEEIV	CTNNB1	556	P35222
DLMNQIQELRTSVCE	KIF15	986	Q9NS87
EMTEQEIDTLCYQLQ	JMY	276	Q8N9B5
EMEQAVELCGRENEV	IKBKB	516	O14920
FQCIEVMQACVAEDQ	IL31RA	326	Q8NI17
EEEECNDHIQRMNFV	HORMAD2	266	Q8N7B1
DCEADQLLQMIRVQQ	ATXN3	171	P54252
EPVVEQLTQEFCERM	CYP21A2	136	P08686
QNNLIETMQRDVFCD	OPTC	276	Q9UBM4
LQEVEVQNEEMAAFC	PIK3C2A	371	O00443
EEEFQQDVMARACLQ	POLG	536	P54098
SVEEQLAQLRCEMEQ	KRT16	381	P08779
EQVFEESCMEVATVN	KCND2	496	Q9NZV8
DIQFVQEMIRQLEQT	MYD88	171	Q99836
VDIIENQVMDFRTQL	GSTM3	101	P21266
EIDMKVIQQRNEECD	GUCY1B1	161	Q02153
RDSCLVQEDMVQVLE	MMEL1	296	Q495T6
QFNRDVLDCVVDEMD	IQSEC3	711	Q9UPP2
MEQVFEQCQQFEEKR	PACSIN2	226	Q9UNF0
VILQEFCNQIIEMTR	DNAH17	336	Q9UFH2
VNQISLDECMEQRQE	DHX57	236	Q6P158
NTEQEIREENMENFC	CCDC73	421	Q6ZRK6
QLEEENQSVCSRMEA	CEP250	621	Q9BV73
EEERTQAESALCQMQ	CEP250	906	Q9BV73
LELTQREFVRQDDCM	FMNL1	926	O95466
LTQSMVDRCIQDEIV	KANSL3	451	Q9P2N6
SEEVSVCQEMLQELR	GRIK5	836	Q16478
MEDAVQILQQCEDLV	GRIP1	636	Q9Y3R0
MVITCQAVVNQREDS	C4orf54	1151	D6RIA3
VLNMVELDCIQEVEV	PRAMEF8	196	Q5VWM4
REDQFMIQVRQEEPC	OTOGL	1986	Q3ZCN5
MERQNQSCVVEFILL	OR10A6	1	Q8NH74
EENLQVMRFAEVTQE	KIF23	421	Q02241
ICEVQEENDFMIQCE	PHF20	656	Q9BVI0
EEINIQMTDQVAETC	RP1	406	P56715
VERELCEQNVEVMLT	CFAP221	771	Q4G0U5
ERIQPEDMFVCDINE	APIP	66	Q96GX9
DRECNNMEIQVDIEA	RNF19B	581	Q6ZMZ0
QVLNRCIQEEEDMRI	SLFN14	171	P0C7P3
MVLREVTECNIETQF	SLC6A16	456	Q9GZN6
VTECESRMVQSIDFQ	SYNE1	4876	Q8NF91
VARMQKEAEEVVQEC	MYH15	1746	Q9Y2K3
TRMVTQINCEFEEVV	SHOC1	26	Q5VXU9
EELEAVQNMVSTVEC	STRBP	26	Q96SI9
VEDTMVETIALCQRN	VPS8	1116	Q8N3P4
LVDMDCFFVQVEQRQ	POLH	11	Q9Y253
EQDVRLLQEIVDQCM	SPTLC1	406	O15269
EQVKSFLENMEVECN	COA7	11	Q96BR5
TLTENEMQFRECSIN	ATP11B	411	Q9Y2G3
VLNMVELDCIQEVEV	PRAMEF7	196	Q5VXH5
REQVEVDAQQCMLEI	nan	41	A6NIZ1
DRVQAVITQMEEVCQ	TRIM54	186	Q9BYV2
VITQMEEVCQTIEDN	TRIM54	191	Q9BYV2
TIMLRDSVIQECVQF	TTC30B	601	Q8N4P2
FEEVVQELRMEQEQI	PLEKHD1	201	A6NEE1
ERFIECIIAEQNMVS	TKTL2	361	Q9H0I9
QESDQCVMEVSDRRN	TFF2	76	Q03403
CQEEQEVKIENNAMV	UBR1	1101	Q8IWV7
CIIEEIARSQETNQM	UBR1	1726	Q8IWV7
CERMSEQIFTNVTQV	TANGO6	651	Q9C0B7
LERCQQQANEVTEIM	VAMP5	6	O95183
RQTMAEVFEKEQSIC	SEC63	476	Q9UGP8
FQVRIDECVRQMADI	UNC13B	1226	O14795
MVQQIQENSVEFEAC	TRIM9	301	Q9C026
QESEVLERQMCPEEQ	SP140	746	Q13342
DCLMQDITVLIQQVE	TRANK1	686	O15050
CSLVIRDAQMQDESQ	SIGLEC10	101	Q96LC7
MNQVEETRYCVDQNL	THOP1	341	P52888
INAEREQPVQCDEMD	TUT4	756	Q5TAX3
CQEEQEVKVESRAMV	UBR2	1111	Q8IWV8
LCSMEEAINERIQEV	RETN	21	Q9HD89
DQRQLLVEVERMECA	TLR4	596	O00206
FRMINEQQVEDITID	PTDSS1	21	P48651
CRFQEDQEMARDLVE	TCF25	296	Q9BQ70
ATLQRQEELETMCVQ	UBXN11	121	Q5T124
QEELETMCVQLQRQV	UBXN11	126	Q5T124
KVQFTVDCNVDIQDM	LRRC8C	286	Q8TDW0
EDQLVMVGQRVEFEC	MYBPC3	461	Q14896
ECAMETTEEQTRQER	NECAB1	151	Q8N987