Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionhistone H3K27 trimethyltransferase activity

EZH1 EZH2

7.46e-063322GO:0140951
GeneOntologyMolecularFunctionhistone H3K27 methyltransferase activity

EZH1 EZH2

3.72e-056322GO:0046976
GeneOntologyMolecularFunctiontransmembrane-ephrin receptor activity

EPHB2 EPHA8

2.58e-0415322GO:0005005
GeneOntologyMolecularFunctionprotein kinase activity

EPHB2 TRIO KALRN MMD2 CHUK EPHA8

3.34e-04600326GO:0004672
GeneOntologyMolecularFunctionephrin receptor activity

EPHB2 EPHA8

4.18e-0419322GO:0005003
GeneOntologyMolecularFunctionphosphotransferase activity, alcohol group as acceptor

EPHB2 TRIO KALRN MMD2 CHUK EPHA8

8.07e-04709326GO:0016773
GeneOntologyMolecularFunctionkinase activity

EPHB2 TRIO KALRN MMD2 CHUK EPHA8

1.19e-03764326GO:0016301
GeneOntologyMolecularFunctionhistone H3 methyltransferase activity

EZH1 EZH2

2.26e-0344322GO:0140938
GeneOntologyMolecularFunctiontransferase activity, transferring phosphorus-containing groups

EPHB2 TRIO KALRN MMD2 CHUK EPHA8

3.36e-03938326GO:0016772
GeneOntologyMolecularFunctiontransmembrane receptor protein tyrosine kinase activity

EPHB2 EPHA8

4.86e-0365322GO:0004714
GeneOntologyMolecularFunctionprotein-lysine N-methyltransferase activity

EZH1 EZH2

5.31e-0368322GO:0016279
GeneOntologyMolecularFunctionlysine N-methyltransferase activity

EZH1 EZH2

5.46e-0369322GO:0016278
GeneOntologyMolecularFunctionhistone methyltransferase activity

EZH1 EZH2

5.77e-0371322GO:0042054
GeneOntologyMolecularFunctionhistone modifying activity

EYA2 EZH1 EZH2

5.78e-03229323GO:0140993
GeneOntologyMolecularFunctionguanyl-nucleotide exchange factor activity

PLEKHG1 TRIO KALRN

5.92e-03231323GO:0005085
GeneOntologyBiologicalProcesshepatocyte homeostasis

EZH1 EZH2

2.48e-062332GO:0036333
GeneOntologyBiologicalProcessregulation of small GTPase mediated signal transduction

EPHB2 PLEKHG1 TRIM67 TRIO KALRN MMD2

1.30e-05333336GO:0051056
GeneOntologyBiologicalProcesssmall GTPase-mediated signal transduction

EPHB2 PLEKHG1 TRIM67 TRIO KALRN MMD2 CHUK

1.87e-05538337GO:0007264
GeneOntologyBiologicalProcessresponse to tetrachloromethane

EZH1 EZH2

2.47e-055332GO:1904772
GeneOntologyBiologicalProcessephrin receptor signaling pathway

EPHB2 KALRN EPHA8

8.75e-0554333GO:0048013
GeneOntologyBiologicalProcesssubtelomeric heterochromatin formation

EZH1 EZH2

8.87e-059332GO:0031509
GeneOntologyBiologicalProcessregulation of Ras protein signal transduction

EPHB2 TRIM67 MMD2

1.26e-0461333GO:0046578
GeneOntologyBiologicalProcessneuron projection development

EPHB2 SPTBN4 DIP2B TRIM67 EZH2 TRIO KALRN TPBG EPHA8

1.36e-041285339GO:0031175
GeneOntologyBiologicalProcesscell morphogenesis involved in neuron differentiation

EPHB2 SPTBN4 DIP2B TRIO KALRN TPBG EPHA8

1.50e-04748337GO:0048667
GeneOntologyBiologicalProcessconstitutive heterochromatin formation

EZH1 EZH2

1.91e-0413332GO:0140719
GeneOntologyBiologicalProcessneuron projection morphogenesis

EPHB2 SPTBN4 DIP2B TRIO KALRN TPBG EPHA8

2.31e-04802337GO:0048812
GeneOntologyBiologicalProcessaxonogenesis

EPHB2 SPTBN4 DIP2B TRIO KALRN EPHA8

2.45e-04566336GO:0007409
GeneOntologyBiologicalProcessplasma membrane bounded cell projection morphogenesis

EPHB2 SPTBN4 DIP2B TRIO KALRN TPBG EPHA8

2.62e-04819337GO:0120039
GeneOntologyBiologicalProcesscell projection morphogenesis

EPHB2 SPTBN4 DIP2B TRIO KALRN TPBG EPHA8

2.76e-04826337GO:0048858
GeneOntologyBiologicalProcessneuron development

EPHB2 SPTBN4 DIP2B TRIM67 EZH2 TRIO KALRN TPBG EPHA8

3.60e-041463339GO:0048666
GeneOntologyBiologicalProcessaxon development

EPHB2 SPTBN4 DIP2B TRIO KALRN EPHA8

4.80e-04642336GO:0061564
GeneOntologyBiologicalProcesspositive regulation of neuron projection development

EPHB2 TRIM67 EZH2 KALRN

6.44e-04249334GO:0010976
GeneOntologyCellularComponentESC/E(Z) complex

EZH1 EZH2

3.24e-0417332GO:0035098
DomainEZH2_WD-Binding

EZH1 EZH2

3.03e-062332PF11616
DomainCXC_dom

EZH1 EZH2

3.03e-062332IPR026489
DomainCXC

EZH1 EZH2

3.03e-062332PS51633
DomainEZH1/EZH2

EZH1 EZH2

3.03e-062332IPR021654
DomainSpectrin

SPTBN4 TRIO KALRN

8.69e-0623333PF00435
DomainSpectrin_repeat

SPTBN4 TRIO KALRN

1.78e-0529333IPR002017
DomainSpectrin/alpha-actinin

SPTBN4 TRIO KALRN

2.41e-0532333IPR018159
DomainSPEC

SPTBN4 TRIO KALRN

2.41e-0532333SM00150
DomainDMAP_binding

DIP2C DIP2B

3.02e-055332PF06464
DomainTesmin/TSO1-like_CXC

EZH1 EZH2

4.52e-056332IPR033467
DomainDMAP_binding

DIP2C DIP2B

4.52e-056332SM01137
DomainCXC

EZH1 EZH2

4.52e-056332SM01114
DomainDMAP1-bd

DIP2C DIP2B

4.52e-056332IPR010506
Domainfn3

EPHB2 TRIM67 KALRN EPHA8

1.83e-04162334PF00041
DomainDH_1

PLEKHG1 TRIO KALRN

1.86e-0463333PS00741
DomainRhoGEF

PLEKHG1 TRIO KALRN

2.33e-0468333SM00325
DomainDH_2

PLEKHG1 TRIO KALRN

2.54e-0470333PS50010
DomainRhoGEF

PLEKHG1 TRIO KALRN

2.54e-0470333PF00621
DomainDH-domain

PLEKHG1 TRIO KALRN

2.65e-0471333IPR000219
Domain-

PLEKHG1 TRIO KALRN

2.65e-04713331.20.900.10
DomainRECEPTOR_TYR_KIN_V_2

EPHB2 EPHA8

2.72e-0414332PS00791
DomainRECEPTOR_TYR_KIN_V_1

EPHB2 EPHA8

2.72e-0414332PS00790
DomainEphA2_TM

EPHB2 EPHA8

2.72e-0414332PF14575
DomainTyr_kinase_ephrin_rcpt

EPHB2 EPHA8

2.72e-0414332IPR016257
DomainEph_TM

EPHB2 EPHA8

2.72e-0414332IPR027936
DomainEphrin_rcpt_lig-bd_dom

EPHB2 EPHA8

2.72e-0414332IPR001090
DomainTyr_kinase_rcpt_V_CS

EPHB2 EPHA8

2.72e-0414332IPR001426
DomainEPH_LBD

EPHB2 EPHA8

2.72e-0414332PS51550
DomainEPH_lbd

EPHB2 EPHA8

2.72e-0414332SM00615
DomainEphrin_lbd

EPHB2 EPHA8

2.72e-0414332PF01404
DomainFN3

EPHB2 TRIM67 KALRN EPHA8

3.05e-04185334SM00060
DomainFN3

EPHB2 TRIM67 KALRN EPHA8

4.02e-04199334PS50853
DomainFN3_dom

EPHB2 TRIM67 KALRN EPHA8

4.83e-04209334IPR003961
DomainSAM

EPHB2 WDSUB1 EPHA8

4.98e-0488333SM00454
DomainCRAL_TRIO

TRIO KALRN

6.23e-0421332PF00650
DomainSAM_DOMAIN

EPHB2 WDSUB1 EPHA8

6.23e-0495333PS50105
DomainSAM

EPHB2 WDSUB1 EPHA8

6.62e-0497333IPR001660
DomainPH

SPTBN4 PLEKHG1 TRIO KALRN

6.81e-04229334PF00169
Domain-

TRIO KALRN

7.48e-04233323.40.525.10
Domain-

EPHB2 WDSUB1 EPHA8

8.57e-041063331.10.150.50
DomainEphrin_rec_like

EPHB2 EPHA8

8.85e-0425332SM01411
DomainSEC14

TRIO KALRN

8.85e-0425332SM00516
DomainTyr-kin_ephrin_A/B_rcpt-like

EPHB2 EPHA8

8.85e-0425332IPR011641
DomainCRAL_TRIO

TRIO KALRN

1.03e-0327332PS50191
DomainCRAL-TRIO_dom

TRIO KALRN

1.11e-0328332IPR001251
DomainSAM/pointed

EPHB2 WDSUB1 EPHA8

1.14e-03117333IPR013761
DomainPROTEIN_KINASE_ATP

EPHB2 TRIO KALRN CHUK EPHA8

1.18e-03459335PS00107
DomainAMP-binding

DIP2C DIP2B

1.28e-0330332PF00501
DomainAMP-dep_Synth/Lig

DIP2C DIP2B

1.28e-0330332IPR000873
DomainPH

SPTBN4 PLEKHG1 TRIO KALRN

1.40e-03278334SM00233
DomainPH_DOMAIN

SPTBN4 PLEKHG1 TRIO KALRN

1.42e-03279334PS50003
DomainPH_domain

SPTBN4 PLEKHG1 TRIO KALRN

1.44e-03280334IPR001849
DomainProt_kinase_dom

EPHB2 TRIO KALRN CHUK EPHA8

1.56e-03489335IPR000719
DomainPROTEIN_KINASE_DOM

EPHB2 TRIO KALRN CHUK EPHA8

1.62e-03493335PS50011
DomainGDS_CDC24_CS

PLEKHG1 TRIO

2.15e-0339332IPR001331
DomainSET

EZH1 EZH2

2.38e-0341332PF00856
DomainKinase-like_dom

EPHB2 TRIO KALRN CHUK EPHA8

2.45e-03542335IPR011009
DomainSET

EZH1 EZH2

2.98e-0346332SM00317
DomainSET_dom

EZH1 EZH2

3.52e-0350332IPR001214
DomainSANT

EZH1 EZH2

3.52e-0350332SM00717
DomainSET

EZH1 EZH2

3.52e-0350332PS50280
DomainSANT/Myb

EZH1 EZH2

3.80e-0352332IPR001005
DomainProtein_kinase_ATP_BS

EPHB2 KALRN CHUK EPHA8

4.29e-03379334IPR017441
Domain-

SPTBN4 PLEKHG1 TRIO KALRN

4.79e-033913342.30.29.30
PathwayREACTOME_NERVOUS_SYSTEM_DEVELOPMENT

EPHB2 SPTBN4 TRIO KALRN EPHA8

5.36e-05261235MM15676
PathwayWP_NODLIKE_RECEPTOR_NLR_SIGNALING

EPHB2 CHUK

9.10e-059232M39494
PathwayWP_NODLIKE_RECEPTOR_NLR_SIGNALING_PATHWAY

EPHB2 CHUK

9.10e-059232MM15889
PathwayBIOCARTA_PRC2_PATHWAY

EZH1 EZH2

1.39e-0411232MM1548
PathwayREACTOME_EPH_EPHRIN_SIGNALING

EPHB2 KALRN EPHA8

1.55e-0465233MM14911
PathwayBIOCARTA_PRC2_PATHWAY

EZH1 EZH2

2.29e-0414232M22025
PathwayWP_INTERACTOME_OF_POLYCOMB_REPRESSIVE_COMPLEX_2_PRC2

EZH1 EZH2

3.01e-0416232M39484
PathwayREACTOME_EPH_EPHRIN_SIGNALING

EPHB2 KALRN EPHA8

4.33e-0492233M27201
PathwayKEGG_MEDICUS_REFERENCE_ACTIVATION_OF_PRC2.2_BY_UBIQUITINATION_OF_H2AK119

EZH1 EZH2

5.77e-0422232M47924
PathwayREACTOME_CONSTITUTIVE_SIGNALING_BY_AKT1_E17K_IN_CANCER

RICTOR CHUK

8.08e-0426232M27558
PathwayKEGG_MEDICUS_REFERENCE_ACTIVATION_OF_PRC2.2_BY_UBIQUITINATION_OF_H2AK119_IN_GERMLINE_GENES

EZH1 EZH2

8.72e-0427232M47941
PathwayREACTOME_DEVELOPMENTAL_BIOLOGY

EPHB2 SPTBN4 TRIO KALRN EPHA8

1.11e-03502235MM14537
PathwayREACTOME_EPH_EPHRIN_MEDIATED_REPULSION_OF_CELLS

EPHB2 EPHA8

1.38e-0334232MM15025
PathwayPID_PI3KCI_AKT_PATHWAY

RICTOR CHUK

1.47e-0335232M249
PathwayREACTOME_DEATH_RECEPTOR_SIGNALING

TRIO KALRN CHUK

1.53e-03142233MM15431
PathwayREACTOME_EPHB_MEDIATED_FORWARD_SIGNALING

EPHB2 KALRN

1.64e-0337232MM15022
PathwayPID_RAC1_REG_PATHWAY

TRIO KALRN

1.73e-0338232M241
PathwayREACTOME_SYNTHESIS_OF_PA

PLA2R1 AGPAT5

1.82e-0339232M653
PathwayWP_NEURAL_CREST_CELL_MIGRATION_DURING_DEVELOPMENT

EPHB2 TRIO

1.91e-0340232M39798
PathwayPID_EPHB_FWD_PATHWAY

EPHB2 KALRN

1.91e-0340232M62
PathwayKEGG_MEDICUS_REFERENCE_GENE_SILENCING_BY_METHYLATION_OF_H3K27_AND_UBIQUITINATION_OF_H2AK119

EZH1 EZH2

1.91e-0340232M47917
PathwayREACTOME_DEATH_RECEPTOR_SIGNALING

TRIO KALRN CHUK

1.93e-03154233M27697
PathwayREACTOME_SYNTHESIS_OF_PA

PLA2R1 AGPAT5

2.01e-0341232MM14583
PathwayREACTOME_NERVOUS_SYSTEM_DEVELOPMENT

EPHB2 SPTBN4 TRIO KALRN EPHA8

2.03e-03575235M29853
PathwayREACTOME_EPHB_MEDIATED_FORWARD_SIGNALING

EPHB2 KALRN

2.11e-0342232M27308
PathwayWP_NEURAL_CREST_CELL_MIGRATION_IN_CANCER

EPHB2 TRIO

2.21e-0343232M39788
Pubmed

The competitive mechanism of EZH1 and EZH2 in promoting oral squamous cell carcinoma.

EZH1 EZH2

9.28e-07234238309675
Pubmed

Sex-biased genetic programs in liver metabolism and liver fibrosis are controlled by EZH1 and EZH2.

EZH1 EZH2

9.28e-07234232428001
Pubmed

Mammalian homologues of the Polycomb-group gene Enhancer of zeste mediate gene silencing in Drosophila heterochromatin and at S. cerevisiae telomeres.

EZH1 EZH2

9.28e-0723429214638
Pubmed

PRC2 specifies ectoderm lineages and maintains pluripotency in primed but not naïve ESCs.

EZH1 EZH2

9.28e-07234228939884
Pubmed

EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair.

EZH1 EZH2

9.28e-07234221317239
Pubmed

Aberrant differential expression of EZH1 and EZH2 in Polycomb repressive complex 2 among B- and T/NK-cell neoplasms.

EZH1 EZH2

9.28e-07234227311868
Pubmed

Characterization of EZH1, a human homolog of Drosophila Enhancer of zeste near BRCA1.

EZH1 EZH2

9.28e-0723428921387
Pubmed

Developmental control of polycomb subunit composition by GATA factors mediates a switch to non-canonical functions.

EZH1 EZH2

9.28e-07234225578878
Pubmed

The methyltransferases enhancer of zeste homolog (EZH) 1 and EZH2 control hepatocyte homeostasis and regeneration.

EZH1 EZH2

9.28e-07234225477280
Pubmed

EZH2 variants differentially regulate polycomb repressive complex 2 in histone methylation and cell differentiation.

EZH1 EZH2

9.28e-07234230522506
Pubmed

The role of EZH1 and EZH2 in development and cancer.

EZH1 EZH2

9.28e-07234236476271
Pubmed

Cloning and expression of a human/mouse Polycomb group gene, ENX-2/Enx-2.

EZH1 EZH2

9.28e-0723429473645
Pubmed

Targeting Excessive EZH1 and EZH2 Activities for Abnormal Histone Methylation and Transcription Network in Malignant Lymphomas.

EZH1 EZH2

9.28e-07234231747604
Pubmed

Polycomb repressive complex 2 (PRC2) silences genes responsible for neurodegeneration.

EZH1 EZH2

9.28e-07234227526204
Pubmed

The murine polycomb-group genes Ezh1 and Ezh2 map close to Hox gene clusters on mouse chromosomes 11 and 6.

EZH1 EZH2

9.28e-07234210051331
Pubmed

EZH1/2 function mostly within canonical PRC2 and exhibit proliferation-dependent redundancy that shapes mutational signatures in cancer.

EZH1 EZH2

9.28e-07234230867289
Pubmed

Rapid induction of dendritic spine morphogenesis by trans-synaptic ephrinB-EphB receptor activation of the Rho-GEF kalirin.

EPHB2 KALRN

9.28e-07234212546821
Pubmed

EZH1 and EZH2 promote skeletal growth by repressing inhibitors of chondrocyte proliferation and hypertrophy.

EZH1 EZH2

9.28e-07234227897169
Pubmed

Kalirin and Trio proteins serve critical roles in excitatory synaptic transmission and LTP.

TRIO KALRN

9.28e-07234226858404
Pubmed

Polycomb Repressive Complex 2 Proteins EZH1 and EZH2 Regulate Timing of Postnatal Hepatocyte Maturation and Fibrosis by Repressing Genes With Euchromatic Promoters in Mice.

EZH1 EZH2

9.28e-07234230689973
Pubmed

CGG-repeat expansion in the DIP2B gene is associated with the fragile site FRA12A on chromosome 12q13.1.

DIP2C DIP2B

2.78e-06334217236128
Pubmed

Signaling function of PRC2 is essential for TCR-driven T cell responses.

EZH1 EZH2

2.78e-06334229523590
Pubmed

Targeting EZH1 and EZH2 contributes to the suppression of fibrosis-associated genes by miR-214-3p in cardiac myofibroblasts.

EZH1 EZH2

2.78e-06334227823969
Pubmed

Ezh1 Targets Bivalent Genes to Maintain Self-Renewing Stem Cells in Ezh2-Insufficient Myelodysplastic Syndrome.

EZH1 EZH2

2.78e-06334230396150
Pubmed

Ezh2 loss in hematopoietic stem cells predisposes mice to develop heterogeneous malignancies in an Ezh1-dependent manner.

EZH1 EZH2

2.78e-06334226219303
Pubmed

The polycomb-group gene Ezh2 is required for early mouse development.

EZH1 EZH2

2.78e-06334211390661
Pubmed

Chronic Myelogenous Leukemia- Initiating Cells Require Polycomb Group Protein EZH2.

EZH1 EZH2

2.78e-06334227630126
Pubmed

Genetic analysis of the role of Eph receptors in the development of the mammalian nervous system.

EPHB2 EPHA8

2.78e-0633429321682
Pubmed

Synaptic Kalirin-7 and Trio Interactomes Reveal a GEF Protein-Dependent Neuroligin-1 Mechanism of Action.

TRIO KALRN

2.78e-06334231801062
Pubmed

eek and erk, new members of the eph subclass of receptor protein-tyrosine kinases.

EPHB2 EPHA8

2.78e-0633421648701
Pubmed

Dependency on the polycomb gene Ezh2 distinguishes fetal from adult hematopoietic stem cells.

EZH1 EZH2

2.78e-06334222042701
Pubmed

Polycomb subunits Ezh1 and Ezh2 regulate the Merkel cell differentiation program in skin stem cells.

EZH1 EZH2

2.78e-06334223673358
Pubmed

Ezh1 and Ezh2 differentially regulate PSD-95 gene transcription in developing hippocampal neurons.

EZH1 EZH2

5.56e-06434223932971
Pubmed

Polycomb Ezh1 maintains murine muscle stem cell quiescence through non-canonical regulation of Notch signaling.

EZH1 EZH2

5.56e-06434237105173
Pubmed

EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency.

EZH1 EZH2

5.56e-06434219026780
Pubmed

Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms.

EZH1 EZH2

5.56e-06434219026781
Pubmed

Regulation of embryonic haematopoietic multipotency by EZH1.

EZH1 EZH2

5.56e-06434229342143
Pubmed

Loss of EZH2 Reprograms BCAA Metabolism to Drive Leukemic Transformation.

EZH1 EZH2

5.56e-06434231189531
Pubmed

New quantitative trait loci that regulate wound healing in an intercross progeny from DBA/1J and 129 x 1/SvJ inbred strains of mice.

EPHB2 EPHA8

9.26e-06534216208538
Pubmed

A covalently bound inhibitor triggers EZH2 degradation through CHIP-mediated ubiquitination.

EZH1 EZH2

9.26e-06534228320739
Pubmed

Assembly of high order G alpha q-effector complexes with RGS proteins.

TRIO KALRN

9.26e-06534218936096
Pubmed

PRC2 insufficiency causes p53-dependent dyserythropoiesis in myelodysplastic syndrome.

EZH1 EZH2

9.26e-06534232820269
Pubmed

Interaction of mouse polycomb-group (Pc-G) proteins Enx1 and Enx2 with Eed: indication for separate Pc-G complexes.

EZH1 EZH2

9.26e-0653429584197
Pubmed

IKK interacts with rictor and regulates mTORC2.

RICTOR CHUK

1.39e-05634223872070
Pubmed

X chromosome reactivation and regulation in cloned embryos.

EZH1 EZH2

1.94e-05734215733677
Pubmed

Loss of Ezh2 in the medial ganglionic eminence alters interneuron fate, cell morphology and gene expression profiles.

EZH1 EZH2

2.59e-05834238419656
Pubmed

Polycomb-like 2 associates with PRC2 and regulates transcriptional networks during mouse embryonic stem cell self-renewal and differentiation.

EZH1 EZH2

2.59e-05834220144788
Pubmed

New insights into BS69 functions.

EZH1 EZH2

2.59e-05834216565076
Pubmed

PRC2 directly methylates GATA4 and represses its transcriptional activity.

EZH1 EZH2

3.33e-05934222215809
Pubmed

EZH1 in germ cells safeguards the function of PRC2 during spermatogenesis.

EZH1 EZH2

3.33e-05934228254491
Pubmed

Ezh2-dependent methylation in oral epithelia promotes secondary palatogenesis.

EZH1 EZH2

3.33e-05934237435868
Pubmed

JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells.

EZH1 EZH2

3.33e-05934220075857
Pubmed

HUWE1 E3 ligase promotes PINK1/PARKIN-independent mitophagy by regulating AMBRA1 activation via IKKα.

GABARAPL2 CHUK

4.15e-051034230217973
Pubmed

Divergent Requirements for EZH1 in Heart Development Versus Regeneration.

EZH1 EZH2

4.15e-051034228512107
Pubmed

EZHIP constrains Polycomb Repressive Complex 2 activity in germ cells.

EZH1 EZH2

4.15e-051034231451685
Pubmed

Polycomb-like 3 promotes polycomb repressive complex 2 binding to CpG islands and embryonic stem cell self-renewal.

EZH1 EZH2

5.07e-051134222438827
Pubmed

Brain proteins interacting with the tetramerization region of non-erythroid alpha spectrin.

SPTBN4 KALRN

5.07e-051134217607528
Pubmed

An H3K36 methylation-engaging Tudor motif of polycomb-like proteins mediates PRC2 complex targeting.

EZH1 EZH2

5.07e-051134223273982
Pubmed

Conditional ablation of Ezh2 in murine hearts reveals its essential roles in endocardial cushion formation, cardiomyocyte proliferation and survival.

EZH1 EZH2

6.08e-051234222312437
Pubmed

Maternal Ezh1/2 deficiency in oocyte delays H3K27me2/3 restoration and impairs epiblast development responsible for embryonic sub-lethality in mouse.

EZH1 EZH2

7.19e-051334235796552
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

DIP2B RICTOR EZH2 INTS3 KLHDC4 CLASRP

9.41e-0577434615302935
Pubmed

Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome.

SPTBN4 DIP2B TRIO KALRN

1.04e-0425134427507650
Pubmed

Dissecting the Roles of Polycomb Repressive Complex 2 Subunits in the Control of Skin Development.

EZH1 EZH2

1.10e-041634226994968
Pubmed

PRC2 Acts as a Critical Timer That Drives Oligodendrocyte Fate over Astrocyte Identity by Repressing the Notch Pathway.

EZH1 EZH2

1.10e-041634232937136
Pubmed

KDM6B interacts with TFDP1 to activate P53 signaling in regulating mouse palatogenesis.

EZH1 EZH2

1.10e-041634235212626
Pubmed

Rnf2 (Ring1b) deficiency causes gastrulation arrest and cell cycle inhibition.

EZH1 EZH2

1.25e-041734212589020
Pubmed

Disruption of segmental neural crest migration and ephrin expression in delta-1 null mice.

EPHB2 EPHA8

1.25e-041734212217323
Pubmed

Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells.

EZH1 EZH2

1.41e-041834219303854
Pubmed

Jumonji modulates polycomb activity and self-renewal versus differentiation of stem cells.

EZH1 EZH2

1.41e-041834220064376
Pubmed

Polycomb repressive complex 2 regulates normal development of the mouse heart.

EZH1 EZH2

1.57e-041934222158708
Pubmed

The polycomb proteins EZH1 and EZH2 co-regulate chromatin accessibility and nephron progenitor cell lifespan in mice.

EZH1 EZH2

1.57e-041934232554463
Pubmed

Protein Palmitoylation by ZDHHC13 Protects Skin against Microbial-Driven Dermatitis.

EPHB2 CHUK

1.57e-041934228017833
Pubmed

Postnatal onset of retinal degeneration by loss of embryonic Ezh2 repression of Six1.

EYA2 EZH2

1.57e-041934227677711
Pubmed

Expression of Ephs and ephrins in developing mouse inner ear.

EPHB2 EPHA8

1.57e-041934212684176
Pubmed

Epigenetic repression of cardiac progenitor gene expression by Ezh2 is required for postnatal cardiac homeostasis.

EZH1 EZH2

1.74e-042034222267199
Pubmed

Eph receptors and ephrins: effectors of morphogenesis.

EPHB2 EPHA8

1.74e-042034210207129
Pubmed

Multiple roles of EPH receptors and ephrins in neural development.

EPHB2 EPHA8

1.74e-042034211256076
Pubmed

The Eph family receptors and ligands.

EPHB2 EPHA8

1.74e-04203429576626
Pubmed

The ephrins and Eph receptors in neural development.

EPHB2 EPHA8

1.74e-04203429530499
Pubmed

Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee.

EPHB2 EPHA8

1.93e-04213429267020
Pubmed

Developmental expression of Eph and ephrin family genes in mammalian small intestine.

EPHB2 EPHA8

1.93e-042134220112066
Pubmed

Eph receptors and ephrins demarcate cerebellar lobules before and during their formation.

EPHB2 EPHA8

1.93e-042134210495276
Pubmed

Roles of Eph receptors and ephrins in segmental patterning.

EPHB2 EPHA8

1.93e-042134211128993
Pubmed

Eph receptors and ephrins: regulators of guidance and assembly.

EPHB2 EPHA8

1.93e-042134210730216
Pubmed

Thalamic afferents influence cortical progenitors via ephrin A5-EphA4 interactions.

EPHB2 EPHA8

2.32e-042334225480914
Pubmed

Unravelling the transcriptional responses of TGF-β: Smad3 and EZH2 constitute a regulatory switch that controls neuroretinal epithelial cell fate specification.

EZH1 EZH2

2.32e-042334230779601
Pubmed

CATACOMB: An endogenous inducible gene that antagonizes H3K27 methylation activity of Polycomb repressive complex 2 via an H3K27M-like mechanism.

EZH1 EZH2

2.32e-042334231281901
Pubmed

Eph receptors and their ephrin ligands are expressed in developing mouse pancreas.

EPHB2 EPHA8

2.53e-042434216446123
Pubmed

Loss of Ezh2 promotes a midbrain-to-forebrain identity switch by direct gene derepression and Wnt-dependent regulation.

EZH1 EZH2

2.74e-042534226621269
Pubmed

Autism candidate gene DIP2A regulates spine morphogenesis via acetylation of cortactin.

DIP2C DIP2B

3.45e-042834231600191
Pubmed

Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals.

SPTBN4 DIP2C CHUK

3.63e-0414234319851296
Pubmed

Stage- and subunit-specific functions of polycomb repressive complex 2 in bladder urothelial formation and regeneration.

EZH1 EZH2

3.70e-042934228049658
Pubmed

Association of genetic variants with hemorrhagic stroke in Japanese individuals.

SPTBN4 DIP2C CHUK

3.71e-0414334320198315
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

DIP2B RICTOR EZH2 INTS3 DHX38

3.99e-0465034538777146
Pubmed

MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development.

EZH1 EZH2 TRIO EPHA8

4.01e-0435834432460013
Pubmed

Polycomb-Mediated Repression and Sonic Hedgehog Signaling Interact to Regulate Merkel Cell Specification during Skin Development.

EZH1 EZH2

4.81e-043334227414999
Pubmed

Multiplexed barcoded CRISPR-Cas9 screening enabled by CombiGEM.

EZH1 EZH2

4.81e-043334226864203
Pubmed

PRC1 sustains the integrity of neural fate in the absence of PRC2 function.

EZH1 EZH2

6.38e-043834234994686
Pubmed

New candidate genes identified for controlling mouse gonadal sex determination and the early stages of granulosa and Sertoli cell differentiation.

CSGALNACT1 MMD2

7.07e-044034219864314
Pubmed

Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature.

EPHB2 EPHA8

7.79e-044234211439183
InteractionMORC3 interactions

SPTBN4 TRIM67 EZH2 KALRN

8.63e-0680334int:MORC3
InteractionRFX2 interactions

EYA2 TRIM67 FOXN4

1.27e-0528333int:RFX2
InteractionEIF2S3B interactions

TRIM67 EZH2 TRIO

1.42e-0529333int:EIF2S3B
InteractionNUDC interactions

ANKRD30B RICTOR GABARAPL2 TRIM67 EZH2 WDFY2

1.58e-05337336int:NUDC
InteractionKALRN interactions

EPHB2 TRIM67 TRIO KALRN

1.78e-0596334int:KALRN
InteractionANK2 interactions

EPHB2 GABARAPL2 TRIM67 KALRN

1.93e-0598334int:ANK2
InteractionEDIL3 interactions

RICTOR TRIM67 EZH2

2.53e-0535333int:EDIL3
InteractionEPHB3 interactions

EPHB2 TRIM67 EPHA8

2.53e-0535333int:EPHB3
InteractionTASOR interactions

RICTOR TRIM67 EZH2 INTS3

3.04e-05110334int:TASOR
InteractionHACD3 interactions

EPHB2 GABARAPL2 TRIM67 EZH2 EPHA8

4.32e-05242335int:HACD3
InteractionCDC37 interactions

EPHB2 SPTBN4 GABARAPL2 TRIM67 TRIO CHUK EPHA8

6.88e-05645337int:CDC37
InteractionCYRIA interactions

RICTOR TRIM67

7.24e-058332int:CYRIA
InteractionNUDT19 interactions

EPHB2 GABARAPL2 TRIM67 EPHA8

7.59e-05139334int:NUDT19
InteractionEPOP interactions

EZH1 EZH2 INTS3

8.37e-0552333int:EPOP
InteractionDIP2C interactions

DIP2C TRIM67

9.29e-059332int:DIP2C
InteractionCTNND2 interactions

ZMYND19 TRIM67 KALRN

9.37e-0554333int:CTNND2
InteractionPDIA4 interactions

EPHB2 RICTOR TRIM67 EZH2 DHX38 EPHA8

9.88e-05468336int:PDIA4
InteractionTMSB10 interactions

RICTOR TRIM67 EZH2

1.05e-0456333int:TMSB10
InteractionINTS8 interactions

TRIM67 EZH2 INTS3

1.42e-0462333int:INTS8
InteractionHYOU1 interactions

EPHB2 RICTOR TRIM67 EZH2 EPHA8

1.54e-04317335int:HYOU1
InteractionARFGAP2 interactions

RICTOR TRIM67 EZH2 EPHA8

1.58e-04168334int:ARFGAP2
InteractionST13P5 interactions

RICTOR TRIM67

1.70e-0412332int:ST13P5
InteractionZNG1E interactions

ZMYND19 TRIM67

1.70e-0412332int:ZNG1E
InteractionSEPTIN3 interactions

EPHB2 GABARAPL2 TRIM67

1.71e-0466333int:SEPTIN3
InteractionGIT1 interactions

EPHB2 RICTOR TRIM67 KALRN

1.73e-04172334int:GIT1
InteractionEFNA5 interactions

EPHB2 RICTOR EPHA8

1.86e-0468333int:EFNA5
InteractionAK3 interactions

GABARAPL2 TRIM67 EZH2

2.03e-0470333int:AK3
InteractionSTK38 interactions

RICTOR TRIM67 EZH1 EZH2

2.15e-04182334int:STK38
InteractionSKIDA1 interactions

EZH1 EZH2

2.34e-0414332int:SKIDA1
InteractionTRIR interactions

RICTOR TRIM67 EZH2

2.40e-0474333int:TRIR
InteractionDIP2B interactions

EPHB2 DIP2B TRIM67

2.49e-0475333int:DIP2B
InteractionKRT6C interactions

RICTOR TRIM67 EZH2

2.59e-0476333int:KRT6C
InteractionNCOR1 interactions

RICTOR GABARAPL2 EYA2 EZH2 CHUK

2.89e-04363335int:NCOR1
InteractionRBBP4 interactions

RICTOR TRIM67 EZH1 EZH2 INTS3 CLASRP

2.96e-04573336int:RBBP4
InteractionRAB35 interactions

EPHB2 DIP2B RICTOR TRIM67 EZH2 TRIO

2.96e-04573336int:RAB35
InteractionTMSB4X interactions

RICTOR TRIM67 EZH2

3.02e-0480333int:TMSB4X
InteractionCLASRP interactions

TRIM67 EZH2 CLASRP

3.02e-0480333int:CLASRP
InteractionLRRC14 interactions

TRIM67 CHUK

3.08e-0416332int:LRRC14
InteractionWWC3 interactions

TRIM67 EZH2

3.08e-0416332int:WWC3
InteractionZNF592 interactions

TRIM67 EZH2 INTS3

3.13e-0481333int:ZNF592
InteractionUSP39 interactions

TRIM67 EZH2 DHX38 TPBG

3.13e-04201334int:USP39
InteractionMYO5A interactions

RICTOR TRIM67 EZH2 KALRN

3.31e-04204334int:MYO5A
InteractionTPX2 interactions

TRIM67 EZH1 EZH2 CHUK

3.31e-04204334int:TPX2
CytobandEnsembl 112 genes in cytogenetic band chr2q24

PLA2R1 WDSUB1

3.79e-03127332chr2q24
GeneFamilyLysine methyltransferases|Myb/SANT domain containing|Polycomb repressive complex 2

EZH1 EZH2

2.97e-0562621347
GeneFamilyFibronectin type III domain containing

EPHB2 TRIM67 KALRN EPHA8

7.59e-05160264555
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

PLEKHG1 TRIO KALRN

1.14e-0466263722
GeneFamilyFibronectin type III domain containing|Sterile alpha motif domain containing|EPH receptors

EPHB2 EPHA8

1.79e-04142621095
GeneFamilySterile alpha motif domain containing

EPHB2 WDSUB1 EPHA8

2.67e-0488263760
GeneFamilyZinc fingers C2H2-type|Lysine methyltransferases|PR/SET domain family

EZH1 EZH2

1.08e-0334262487
GeneFamilyGATA zinc finger domain containing|Myb/SANT domain containing

EZH1 EZH2

2.62e-0353262532
GeneFamilyBlood group antigens|CD molecules|I-set domain containing|Immunoglobulin like domain containing

TRIO KALRN

2.23e-02161262593
ToppCellrenal_cortex_nuclei|World / Celltypes from Cells and Nuclei per compartment and clinical group

DIP2C DIP2B MED13L TRIO

1.35e-05192344e8cc4d08fcfceeab75a02558817e4ccd7dbafe3a
ToppCellTracheal-NucSeq|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations

DIP2C DIP2B MED13L TRIO

1.55e-0519934494b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Oligodendroglioma-3|TCGA-Brain / Sample_Type by Project: Shred V9

DIP2B RICTOR MED13L

1.48e-04135343b128596653a5e3b64ed7f657bbfeda35438e2e48
ToppCellLPS-antiTNF-Epithelial_alveolar-Mes-like-Differentiating_AT2|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ZMYND19 TRIM67 CSGALNACT1

1.71e-041423435690eee2ce1ecd02e34eac4193578bd13c4228b9
ToppCellEndothelial-endothelial_cell_of_bronchial_vessel|World / Lineage, Cell type, age group and donor

PLEKHG1 KALRN CSGALNACT1

2.67e-0416534384e553d699ac56df89a77248f7308b9133e1b683
ToppCellEndothelial-B-HP_01|World / lung cells shred on cell class, cell subclass, sample id

PLA2R1 KALRN CSGALNACT1

2.67e-0416534310087d8bd2985906ef19547fe77eb178ae5e1638
ToppCellChildren_(3_yrs)-Immune-B_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

PLEKHG1 TRIM67 CSGALNACT1

2.91e-04170343e421f9eedf74baffda1d03707a710ece4b777f29
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

EPHB2 TRIO CSGALNACT1

3.01e-041723430c2d0bb767e5ce089b42ad49e8b303a103de2d5c
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

EPHB2 TRIO CSGALNACT1

3.01e-04172343eeed177a03c116e9815a8e086d24efc9643b16a4
ToppCellAdult-Endothelial-endothelial_cell_of_bronchial_vessel|Adult / Lineage, Cell type, age group and donor

PLEKHG1 KALRN CSGALNACT1

3.01e-04172343ad4ffdb3fc0c560a9cbaa2bc048476cbc43e8fd6
ToppCellAdult-Endothelial-endothelial_cell_of_lymph_vessel-D122|Adult / Lineage, Cell type, age group and donor

PLEKHG1 KALRN CSGALNACT1

3.06e-04173343dba09ba9748871e38a16449d500ae4d7b405c42f
ToppCellControl-Neuronal_cells|Control / group, cell type (main and fine annotations)

PLEKHG1 KALRN CSGALNACT1

3.22e-04176343c29d09ecf0eb17f767d78af4b7f2e7725c967ff8
ToppCellControl-Neuronal_cells-Neuronal_cells|Control / group, cell type (main and fine annotations)

PLEKHG1 KALRN CSGALNACT1

3.22e-0417634398c07d26ba0dc0fe15ca0ea81f633d4591782bd1
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma|TCGA-Brain / Sample_Type by Project: Shred V9

DIP2C RICTOR EZH1

3.27e-04177343e8ab340b20cd41554c3841fe980e078e878af35f
ToppCellAdult-Endothelial-endothelial_cell_of_bronchial_vessel-D175|Adult / Lineage, Cell type, age group and donor

PLEKHG1 KALRN CSGALNACT1

3.27e-04177343c9f269765c7d5d29caab75910e51645606ed562e
ToppCellAdult-Endothelial-endothelial_cell_of_lymph_vessel-D231|Adult / Lineage, Cell type, age group and donor

PLEKHG1 KALRN CSGALNACT1

3.33e-04178343c80ca7a2d3f976089a5e71d0cd9ba9a1c0bd2815
ToppCelldroplet-Liver-nan-3m-Endothelial-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLEKHG1 PLA2R1 KALRN

3.50e-04181343fcc94f04dae98b817ec06b282d2e887804d37ae5
ToppCellFetal_29-31_weeks-Mesenchymal-myofibroblast_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

DIP2C TRIO KALRN

3.55e-04182343ed6ae0fd8653f213fe29906a6a4e0729a62e1b75
ToppCellfacs-Lung-EPCAM-3m-Epithelial-Basal|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPHB2 EYA2 TPBG

3.61e-04183343ecac1cfaff7553a60305b34d6cede6973ffb5430
ToppCellfacs-Lung-EPCAM-3m-Epithelial-respiratory_basal_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPHB2 EYA2 TPBG

3.61e-04183343f6ebfd7f61e912f92bd07313cc213a171747ac03
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive|renal_medulla_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group

PLEKHG1 TRIO CSGALNACT1

3.67e-04184343d2bf0135eb56bb410997dccea39c5ede88a0617f
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DIP2C PPP2R3A CSGALNACT1

3.79e-04186343f0c8de4f6ae9047b9108a47a2af8c5f42bc103b0
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Degenerative_Descending_Thin_Limb_Cell_Type_3|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DIP2C PPP2R3A CSGALNACT1

3.85e-04187343c31130fc2f9f882944b2ba366a034a03f051c4b9
ToppCellIPF-Lymphoid-B|Lymphoid / Disease state, Lineage and Cell class

PLEKHG1 DIP2B TRIO

3.85e-04187343af1327559f7e01bec070881cae52834917c3da65
ToppCellAdult-Endothelial-endothelial_cell_of_lymph_vessel-D175|Adult / Lineage, Cell type, age group and donor

PLEKHG1 KALRN CSGALNACT1

3.85e-041873431e52d3d9d664c813d859b5b75e4c07b218818f95
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DIP2C PPP2R3A CSGALNACT1

3.91e-04188343af740fa78542438fdff627ea1f74f4eee43316be
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRIM67 TPBG EPHA8

3.91e-041883431efbc99bcd6542e5d9fa91edb7c4295167914786
ToppCellCOPD-Endothelial-VE_Capillary_A|Endothelial / Disease state, Lineage and Cell class

PLEKHG1 MED13L KALRN

3.91e-041883431aa0e35b1c28ac847886fece16c3ef7fc6fcdd51
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_lymph_vessel|Children_(3_yrs) / Lineage, Cell type, age group and donor

PLEKHG1 KALRN CSGALNACT1

3.91e-04188343c2805232618a7b6f844d34e37ad458a9923dbfe1
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_lymph_vessel-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

PLEKHG1 KALRN CSGALNACT1

3.91e-04188343aeecbc057dc823f8fcea8a98f18d213bacc7f4db
ToppCelldroplet-Lung-30m-Hematologic-myeloid-alveolar_macrophage-alveolar_macrophage|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DIP2C PLEKHG1 KLHDC4

3.97e-0418934398f517af255ef234eefc3ed7e6c1d63331ab8af0
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

EPHB2 TRIO CSGALNACT1

3.97e-041893438c8ca3b30d9be6c854615459a7bfba82b427c8bc
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPTBN4 TRIM67 EPHA8

3.97e-04189343f57200c93d39c9bce1adba0a6a1c178c028dd86b
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

EPHB2 TRIO CSGALNACT1

3.97e-041893435d902a4660a27548764bf04c6de152b565da835c
ToppCelldroplet-Lung-30m-Hematologic-myeloid-alveolar_macrophage|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DIP2C PLEKHG1 KLHDC4

3.97e-04189343f7e9b6e6a4de297b660a5b6c9a62f860c147185e
ToppCellAdult-Endothelial-endothelial_cell_of_lymph_vessel|Adult / Lineage, Cell type, age group and donor

PLEKHG1 KALRN CSGALNACT1

4.03e-0419034391bf3b7e9148589757436a53a4f58e0ebfe54400
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_lymph_vessel-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

PLEKHG1 KALRN CSGALNACT1

4.03e-041903436e6ce6dd549d1c38cfef5b3f8be06ab01ce344b7
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_B-B_cell-B_c03-CD27-AIM2|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

PLEKHG1 EZH2 TRIO

4.03e-041903430db545a4cba7534bad2693e0d565cde7dbc7a586
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro1_(4)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

PLA2R1 EYA2 KALRN

4.09e-04191343fa380a8752de158974b2ae5e741573439719cc0d
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

EPHB2 PPP2R3A TRIO

4.09e-04191343d0e9afe7b6334dd515d3e68892efdc76347a55e5
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

EPHB2 PPP2R3A TRIO

4.09e-041913439032aa974aa1b7b1095b8d1b58dcb087358a5001
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

EPHB2 PPP2R3A TRIO

4.09e-041913435717809a1476c20f65bce722c5a57cff92ee0d7a
ToppCellLPS_only-Endothelial-Endothelial-Activated_Alv_Cap|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PLEKHG1 PLA2R1 CSGALNACT1

4.09e-04191343a7b18bcf27c38ad2353c239ecb309c80f3ef3359
ToppCellwk_08-11-Mesenchymal-Fibroblast-Mesenchymal_3|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

EPHB2 TRIO TPBG

4.15e-04192343d88753b200d9c8da6716222d697ddf0a1548d6c8
ToppCell3'-Distal_airway-Endothelial-Lymphatic_EC|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PLEKHG1 AGPAT5 KALRN

4.15e-041923432ec132a1740e865e7cc0f82ffd4772d43f7ac086
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_chondroblast_(18)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

EYA2 CSGALNACT1 TPBG

4.15e-041923433a6f2c255da46a0b0f5b657b0f56f3d7798ae85a
ToppCell3'-Distal_airway-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_mature|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PLEKHG1 AGPAT5 KALRN

4.15e-041923433792c53b5d4b759573e1c7bb89ef9b654c9cbfcd
ToppCell3'-Distal_airway-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PLEKHG1 AGPAT5 KALRN

4.15e-0419234364022a47dccd7966777f6741d1c68e298f37ca9d
ToppCell3'-Distal_airway-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_mature-Lymphatic_EC_mature_L.2.5.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PLEKHG1 AGPAT5 KALRN

4.15e-04192343f67a88bd039944d3d7a5a4a9f2e053985075155c
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PLEKHG1 KALRN CSGALNACT1

4.15e-0419234328eb3a5728e8901bcb5ba12f6b009f41b065fa37
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD|renal_papilla_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group

EPHB2 DIP2C CSGALNACT1

4.22e-04193343ca7c0a4ceb05bced90f6cdc53d278e547fb241e9
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_B-B_cell-B_c02-MS4A1-CD27|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

PLEKHG1 AGPAT5 EZH2

4.28e-041943435cd72330c9d9bb21b6c9d5d35085eade101486d1
ToppCellmoderate-Epithelial-FOXN4+|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

AGPAT5 EZH2 FOXN4

4.28e-04194343dff3fb10372053951d41e0ccd41aac3ece6009bd
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PLEKHG1 TRIO CSGALNACT1

4.35e-04195343938b31dbf1674ee6fd0123bc88391ddcaf151217
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PLEKHG1 KALRN CSGALNACT1

4.35e-041953436bdef651cf73d7381e5012d0eb3c809138fb6b92
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PLEKHG1 TRIO CSGALNACT1

4.35e-04195343d39e9e6544f49e677ebe528c6fe60b99a3630e30
ToppCell367C-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

DIP2C EYA2 CSGALNACT1

4.35e-041953434008fa86b5166087a4b20f89ae07e1dfc87c855d
ToppCellBronchial-NucSeq-Immune_Lymphocytic-B-B_cell-B_naive|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

PLEKHG1 AGPAT5 FOXN4

4.41e-04196343de43dd0697e1daf4d50800957cf0b27b54a7a333
ToppCellCOVID-19-Fibroblasts-Intermediate_pathological_FB|COVID-19 / group, cell type (main and fine annotations)

DIP2C PLA2R1 KALRN

4.48e-04197343f1c8936986123a3151140c374fcd62d6705c530b
ToppCellParenchymal-NucSeq-Endothelial-Endothelia_lymphatic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

PLEKHG1 KALRN CSGALNACT1

4.54e-041983439ab0db78394e730f6866b2db80047149024ad5f6
ToppCellParenchymal-NucSeq|Parenchymal / Cell types per location group and 10X technology with lineage, and cell group designations

DIP2C MED13L TRIO

4.54e-041983431996373bdccc55aac347d349bd22f6aad6d0c668
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PLEKHG1 KALRN CSGALNACT1

4.54e-04198343b027a141ab531d0f5d6a26811a53427e7b0771dd
ToppCellBronchial-NucSeq-Endothelial-Endothelia_lymphatic-Endothelia_Lymphatic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

PLEKHG1 KALRN CSGALNACT1

4.54e-04198343b3a020522e064bb61949d38e442f24026e339364
ToppCellBronchial-NucSeq-Endothelial-Endothelia_lymphatic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

PLEKHG1 KALRN CSGALNACT1

4.54e-04198343fc4b7c3ad52bc5c8b40fa04a156bfbb58afa2872
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PLEKHG1 KALRN CSGALNACT1

4.54e-041983438e45551224fbb30c0658ad47dd98335ecf165437
ToppCellParenchymal-NucSeq-Endothelial-Endothelia_lymphatic-Endothelia_Lymphatic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

PLEKHG1 KALRN CSGALNACT1

4.54e-04198343e47d0e2c6353315c85d7007742bb16b0f05795ed
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PLEKHG1 KALRN CSGALNACT1

4.54e-04198343953630dbe3154b1b102b87de0feca2cbf124eabe
ToppCellParenchymal-NucSeq-Endothelial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

PLEKHG1 KALRN CSGALNACT1

4.61e-04199343a4a9a1c2a34b5a8318a55d1211d6c8661ca9793e
ToppCellHematolymphoid-Microglia|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

MED13L CSGALNACT1 WDFY2

4.68e-0420034321bcca3b670fe9bac034aef2275d3de4a9a73e2b
ToppCellHematolymphoid-Microglia-TYROBP----L1-3|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

MED13L CSGALNACT1 WDFY2

4.68e-04200343a20dce14f94777687aad57d6fbe3258ad376f63f
ToppCellHematolymphoid-Microglia-TYROBP--|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

MED13L CSGALNACT1 WDFY2

4.68e-04200343dc344b3ec51d506952e38f0b3a7795d65f9dd4eb
ToppCellHematolymphoid-Microglia-TYROBP---|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

MED13L CSGALNACT1 WDFY2

4.68e-04200343a8646d0fca99f10827c2d2a12e584660ef7155f1
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW23-Macroglial-Astrocyte|GW23 / Sample Type, Dataset, Time_group, and Cell type.

PLEKHG1 EYA2 CSGALNACT1

4.68e-042003434fe3b2d80c567c18621bff3341f9a73578c81621
ToppCellHematolymphoid-Microglia-TYROBP-|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

MED13L CSGALNACT1 WDFY2

4.68e-042003433bba5219453322198e8fdb0921d5f8c403598751
ToppCellHematolymphoid-Microglia-TYROBP|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

MED13L CSGALNACT1 WDFY2

4.68e-0420034333036d21c1c82109284473a515c4f890b33fdd5c
ToppCellTracheal-NucSeq-Epithelial-Epi_submucosal-gland-SMG_Serous|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

PLA2R1 PPP2R3A EYA2

4.68e-042003437c2d499af60654b7b28f172ac2c914ad49fb74b4
Drug7-heptacosene

EZH1 EZH2

5.74e-063322CID006430696
Diseaseinterferon gamma measurement

EPHB2 TPBG EPHA8

2.56e-0551333EFO_0008165
Diseasecolon cancer (is_marker_for)

RICTOR EZH2 CHUK

3.97e-0559333DOID:219 (is_marker_for)
Diseasecomplement C1q subcomponent subunit C measurement

EPHB2 EPHA8

5.43e-0510332EFO_0801492
Diseaserostral middle frontal gyrus volume measurement

ZMYND19 PLA2R1

1.09e-0414332EFO_0010328
Diseasetumor necrosis factor beta measurement

EPHB2 EPHA8

1.26e-0415332EFO_0008308
Diseaseautosomal dominant intellectual developmental disorder (is_implicated_in)

DIP2B TRIO

1.63e-0417332DOID:0060307 (is_implicated_in)
Diseasemacrophage colony stimulating factor measurement

EPHB2 EPHA8

7.88e-0437332EFO_0008217
DiseaseMetastatic melanoma

TRIO EPHA8

1.67e-0354332C0278883
DiseaseIschemic stroke, fibrinogen measurement

DIP2B PPP2R3A

1.74e-0355332EFO_0004623, HP_0002140
Diseasefree cholesterol measurement, very low density lipoprotein cholesterol measurement

PPP2R3A CSGALNACT1 DHX38

1.77e-03215333EFO_0008317, EFO_0008591
Diseasevery low density lipoprotein cholesterol measurement, lipid measurement

PPP2R3A CSGALNACT1 DHX38

1.89e-03220333EFO_0004529, EFO_0008317
Diseasefibrinogen measurement, factor VII measurement

DIP2B PPP2R3A

1.93e-0358332EFO_0004619, EFO_0004623
Diseasetotal cholesterol measurement, very low density lipoprotein cholesterol measurement

PPP2R3A CSGALNACT1 DHX38

1.99e-03224333EFO_0004574, EFO_0008317
Diseasevery low density lipoprotein cholesterol measurement, phospholipid measurement

PPP2R3A CSGALNACT1 DHX38

2.12e-03229333EFO_0004639, EFO_0008317
Diseaseretinal vasculature measurement

PLEKHG1 PPP2R3A MED13L TRIO

2.55e-03517334EFO_0010554
Diseasenephrotic syndrome

ZNF438 KALRN

2.87e-0371332EFO_0004255
Diseasevery low density lipoprotein cholesterol measurement

PPP2R3A CSGALNACT1 DHX38

3.03e-03260333EFO_0008317
Diseaselung cancer (is_implicated_in)

RICTOR EZH2

3.12e-0374332DOID:1324 (is_implicated_in)
Diseaseesophagus squamous cell carcinoma (is_marker_for)

RICTOR EZH2

3.12e-0374332DOID:3748 (is_marker_for)
DiseaseCleft Palate

MED13L CHUK

3.72e-0381332C0008925
Diseaseotosclerosis

ZNF438 EYA2

3.72e-0381332EFO_0004213
Diseasesleep duration, low density lipoprotein cholesterol measurement

DHX38 CLASRP

4.67e-0391332EFO_0004611, EFO_0005271
DiseaseNeurodevelopmental Disorders

MED13L TRIO

4.87e-0393332C1535926
Diseasemalaria

DIP2C PLEKHG1

5.83e-03102332EFO_0001068
DiseaseDNA methylation

MMD2 TRIO MMD2 TPBG

5.94e-03656334GO_0006306

Protein segments in the cluster

PeptideGeneStartEntry
MKKRTALHWACVNGH

ANKRD30B

71

Q9BXX2
GLFHLWHEKRCMDEL

CSGALNACT1

471

Q8TDX6
ILRHWCMKHDELLAE

INTS3

876

Q68E01
WKKSHLRMVEHCLHM

MMD2

91

Q8IY49
KLHNHMVHRVWKECI

MED13L

371

Q71F56
ERWCHEIQIMKKLNH

CHUK

56

O15111
HQLMLDCWQKDRNHR

EPHB2

856

P29323
HRLWAAHCRKIQLKK

EZH2

496

Q15910
HQMWHVRKLKLDQCF

KALRN

296

O60229
KCRDLHWAMMAHRDQ

DIP2B

611

Q9P265
MWRKLLNNHHDDASK

PPP2R3A

786

Q06190
KCHNWDAVRHSRKHL

RICTOR

986

Q6R327
ALHQLMLDCWHKDRA

EPHA8

866

P29322
VKSRDMHWALVAHRD

DIP2C

591

Q9Y2E4
SDLHCLDLHRMEAWK

KLHDC4

461

Q8TBB5
MKWMFKEDHSLEHRC

GABARAPL2

1

P60520
KKHNMPFWRISCHAD

EYA2

511

O00167
EMHKWKRKDLAAIHR

FOXN4

281

Q96NZ1
HKKKHMRWRSLCCQG

NANOGNB

166

Q7Z5D8
LGRWEVKHCRHFKAM

PLA2R1

626

Q13018
MWHEARKHERKLRGM

CLASRP

1

Q8N2M8
REHKLKMVWDQINHC

TRIM67

416

Q6ZTA4
QQKDWPAHKKHCRER

ZMYND19

201

Q96E35
MWDSKKIGLRQHHCR

WDFY2

301

Q96P53
QKKKRKHRLWAAHCR

EZH1

491

Q92800
KHRLWAAHCRKIQLK

EZH1

496

Q92800
NHKLHKRWLRHQAFM

SPTBN4

1336

Q9H254
IWCNDHFIHAKAMRK

DHX38

1026

Q92620
IKKWMHNIRDACRDH

TPBG

381

Q13641
VAWHINDMKRKHEHA

PLEKHG1

286

Q9ULL1
WDDKMRCLHSEKAHD

WDSUB1

166

Q8N9V3
HMRRWLHERFEIKDK

AGPAT5

276

Q9NUQ2
CAEMLGRKEDLLHHW

ZNF438

781

Q7Z4V0
HQMWHVRKLKLDQCF

TRIO

326

O75962