Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	extracellular matrix constituent conferring elasticity	LAMC1 FBN1 FBN2	1.17e-06	12	36	3	GO:0030023
GeneOntologyMolecularFunction	structural molecule activity conferring elasticity	LAMC1 FBN1 FBN2	1.93e-06	14	36	3	GO:0097493
GeneOntologyBiologicalProcess	sequestering of TGFbeta in extracellular matrix	FBN1 FBN2	1.77e-05	4	36	2	GO:0035583
GeneOntologyBiologicalProcess	maintenance of protein location in extracellular region	FBN1 FBN2	8.24e-05	8	36	2	GO:0071694
GeneOntologyCellularComponent	microfibril	FBN1 FBN2	2.10e-04	13	35	2	GO:0001527
GeneOntologyCellularComponent	NuRD complex	CHD3 CHD5	3.65e-04	17	35	2	GO:0016581
GeneOntologyCellularComponent	CHD-type complex	CHD3 CHD5	3.65e-04	17	35	2	GO:0090545
GeneOntologyCellularComponent	perinuclear endoplasmic reticulum	ADAM10 OSBPL3	1.07e-03	29	35	2	GO:0097038
GeneOntologyCellularComponent	basement membrane	LAMC1 ALB FBN1	1.11e-03	122	35	3	GO:0005604
HumanPheno	Abnormal upper to lower segment ratio	FBN1 FBN2	1.52e-05	3	12	2	HP:0012772
HumanPheno	Crumpled ear	FBN1 FBN2	7.59e-05	6	12	2	HP:0009901
Domain	CHDCT2	CHD3 CHD5	1.08e-05	3	36	2	PF08074
Domain	CHDNT	CHD3 CHD5	1.08e-05	3	36	2	PF08073
Domain	DUF1086	CHD3 CHD5	1.08e-05	3	36	2	IPR009462
Domain	DUF1087	CHD3 CHD5	1.08e-05	3	36	2	IPR009463
Domain	DUF1087	CHD3 CHD5	1.08e-05	3	36	2	PF06465
Domain	DUF1086	CHD3 CHD5	1.08e-05	3	36	2	PF06461
Domain	DUF1087	CHD3 CHD5	1.08e-05	3	36	2	SM01147
Domain	DUF1086	CHD3 CHD5	1.08e-05	3	36	2	SM01146
Domain	CHD_N	CHD3 CHD5	1.08e-05	3	36	2	IPR012958
Domain	CHD_C2	CHD3 CHD5	1.08e-05	3	36	2	IPR012957
Domain	FBN	FBN1 FBN2	1.08e-05	3	36	2	IPR011398
Domain	zf-FCS	ZMYM4 ZMYM6	7.54e-05	7	36	2	PF06467
Domain	TB	FBN1 FBN2	7.54e-05	7	36	2	PF00683
Domain	Znf_MYM	ZMYM4 ZMYM6	7.54e-05	7	36	2	IPR010507
Domain	TRASH_dom	ZMYM4 ZMYM6	1.00e-04	8	36	2	IPR011017
Domain	-	FBN1 FBN2	1.00e-04	8	36	2	3.90.290.10
Domain	TRASH	ZMYM4 ZMYM6	1.00e-04	8	36	2	SM00746
Domain	TB	FBN1 FBN2	1.29e-04	9	36	2	PS51364
Domain	TB_dom	FBN1 FBN2	1.29e-04	9	36	2	IPR017878
Domain	Znf_PHD-finger	KDM2B CHD3 CHD5	4.70e-04	79	36	3	IPR019787
Domain	PHD	KDM2B CHD3 CHD5	6.67e-04	89	36	3	SM00249
Domain	Znf_PHD	KDM2B CHD3 CHD5	7.11e-04	91	36	3	IPR001965
Domain	ZF_PHD_2	KDM2B CHD3 CHD5	8.06e-04	95	36	3	PS50016
Domain	ZF_PHD_1	KDM2B CHD3 CHD5	8.31e-04	96	36	3	PS01359
Domain	Chromo_domain	CHD3 CHD5	9.71e-04	24	36	2	IPR023780
Domain	EGF	LAMC1 FBN1 FBN2 MALRD1	1.05e-03	235	36	4	SM00181
Domain	cEGF	FBN1 FBN2	1.14e-03	26	36	2	IPR026823
Domain	Chromo	CHD3 CHD5	1.14e-03	26	36	2	PF00385
Domain	cEGF	FBN1 FBN2	1.14e-03	26	36	2	PF12662
Domain	EGF-like_dom	LAMC1 FBN1 FBN2 MALRD1	1.30e-03	249	36	4	IPR000742
Domain	CHROMO_2	CHD3 CHD5	1.32e-03	28	36	2	PS50013
Domain	CHROMO_1	CHD3 CHD5	1.32e-03	28	36	2	PS00598
Domain	EGF_1	LAMC1 FBN1 FBN2 MALRD1	1.42e-03	255	36	4	PS00022
Domain	EGF-like_CS	LAMC1 FBN1 FBN2 MALRD1	1.54e-03	261	36	4	IPR013032
Domain	EGF_2	LAMC1 FBN1 FBN2 MALRD1	1.63e-03	265	36	4	PS01186
Domain	SNF2_N	CHD3 CHD5	1.73e-03	32	36	2	PF00176
Domain	SNF2_N	CHD3 CHD5	1.73e-03	32	36	2	IPR000330
Domain	Chromodomain-like	CHD3 CHD5	1.73e-03	32	36	2	IPR016197
Domain	CHROMO	CHD3 CHD5	1.84e-03	33	36	2	SM00298
Domain	Chromo/shadow_dom	CHD3 CHD5	1.84e-03	33	36	2	IPR000953
Domain	DNA/RNA_helicase_DEAH_CS	CHD3 CHD5	2.07e-03	35	36	2	IPR002464
Domain	DEAH_ATP_HELICASE	CHD3 CHD5	2.43e-03	38	36	2	PS00690
Domain	Znf_FYVE_PHD	KDM2B CHD3 CHD5	2.82e-03	147	36	3	IPR011011
Domain	Growth_fac_rcpt_	LAMC1 FBN1 FBN2	3.33e-03	156	36	3	IPR009030
Domain	-	CHD3 CHD5	5.03e-03	55	36	2	1.10.30.10
Domain	Zinc_finger_PHD-type_CS	CHD3 CHD5	6.96e-03	65	36	2	IPR019786
Domain	HMG_box_dom	CHD3 CHD5	6.96e-03	65	36	2	IPR009071
Domain	Ank_2	ANKRD31 TEX14 TRPC3	8.12e-03	215	36	3	PF12796
Domain	PHD	CHD3 CHD5	9.18e-03	75	36	2	PF00628
Domain	Ank	ANKRD31 TEX14 TRPC3	9.53e-03	228	36	3	PF00023
Domain	EGF_3	FBN1 FBN2 MALRD1	1.03e-02	235	36	3	PS50026
Pathway	REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_TRANSPORT_AND_UPTAKE_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS	LAMC1 ALB FBN1 ADAM10	5.29e-05	124	24	4	M27285
Pathway	REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX	LAMC1 FBN1 FBN2 ADAM10	8.48e-05	140	24	4	M587
Pubmed	Adamts18 modulates the development of the aortic arch and common carotid artery.	LAMC1 FBN1 FBN2 ADAM10	1.59e-08	26	37	4	34189436
Pubmed	ADAMTS18-fibronectin interaction regulates the morphology of liver sinusoidal endothelial cells.	LAMC1 FBN1 FBN2	8.94e-07	18	37	3	39040056
Pubmed	Homo- and heterotypic fibrillin-1 and -2 interactions constitute the basis for the assembly of microfibrils.	FBN1 FBN2	1.10e-06	2	37	2	12399449
Pubmed	Fibrillin-1 and fibrillin-2 are essential for formation of thick oxytalan fibers in human nonpigmented ciliary epithelial cells in vitro.	FBN1 FBN2	1.10e-06	2	37	2	21851253
Pubmed	Fibrillins can co-assemble in fibrils, but fibrillin fibril composition displays cell-specific differences.	FBN1 FBN2	1.10e-06	2	37	2	12429739
Pubmed	Rare variants in FBN1 and FBN2 are associated with severe adolescent idiopathic scoliosis.	FBN1 FBN2	1.10e-06	2	37	2	24833718
Pubmed	New Evidence Supporting the Role of FBN1 in the Development of Adolescent Idiopathic Scoliosis.	FBN1 FBN2	1.10e-06	2	37	2	30044367
Pubmed	Material and mechanical properties of bones deficient for fibrillin-1 or fibrillin-2 microfibrils.	FBN1 FBN2	1.10e-06	2	37	2	21440062
Pubmed	MAGP-2 has multiple binding regions on fibrillins and has covalent periodic association with fibrillin-containing microfibrils.	FBN1 FBN2	1.10e-06	2	37	2	15131124
Pubmed	Nonselective assembly of fibrillin 1 and fibrillin 2 in the rodent ocular zonule and in cultured cells: implications for Marfan syndrome.	FBN1 FBN2	1.10e-06	2	37	2	24265020
Pubmed	Fibrillin-1 and fibrillin-2 in human embryonic and early fetal development.	FBN1 FBN2	1.10e-06	2	37	2	12524050
Pubmed	In vivo studies of mutant fibrillin-1 microfibrils.	FBN1 FBN2	1.10e-06	2	37	2	20529844
Pubmed	Immunohistochemical expression of fibrillin-1 and fibrillin-2 during tooth development.	FBN1 FBN2	1.10e-06	2	37	2	25524144
Pubmed	Microfibril structure masks fibrillin-2 in postnatal tissues.	FBN1 FBN2	1.10e-06	2	37	2	20404337
Pubmed	Fibrillin-1 mutations causing Weill-Marchesani syndrome and acromicric and geleophysic dysplasias disrupt heparan sulfate interactions.	FBN1 FBN2	1.10e-06	2	37	2	23133647
Pubmed	Fibrillln mutations in Marfan syndrome and related phenotypes.	FBN1 FBN2	1.10e-06	2	37	2	8791520
Pubmed	Structure and expression of fibrillin-2, a novel microfibrillar component preferentially located in elastic matrices.	FBN1 FBN2	1.10e-06	2	37	2	8120105
Pubmed	The fibrillinopathies: New insights with focus on the paradigm of opposing phenotypes for both FBN1 and FBN2.	FBN1 FBN2	1.10e-06	2	37	2	35419902
Pubmed	Hepatocyte-specific METTL3 ablation by Alb-iCre mice (GPT), but not by Alb-Cre mice (JAX), resulted in acute liver failure (ALF) and postnatal lethality.	METTL3 ALB	1.10e-06	2	37	2	38656880
Pubmed	Fibrillin genes map to regions of conserved mouse/human synteny on mouse chromosomes 2 and 18.	FBN1 FBN2	1.10e-06	2	37	2	8307578
Pubmed	Fibrillins 1 and 2 perform partially overlapping functions during aortic development.	FBN1 FBN2	1.10e-06	2	37	2	16407178
Pubmed	Fibrillin assembly: dimer formation mediated by amino-terminal sequences.	FBN1 FBN2	1.10e-06	2	37	2	10504303
Pubmed	Linkage of Marfan syndrome and a phenotypically related disorder to two different fibrillin genes.	FBN1 FBN2	1.10e-06	2	37	2	1852206
Pubmed	N-terminal domains of fibrillin 1 and fibrillin 2 direct the formation of homodimers: a possible first step in microfibril assembly.	FBN1 FBN2	1.10e-06	2	37	2	10359653
Pubmed	Developmental expression of fibrillin genes suggests heterogeneity of extracellular microfibrils.	FBN1 FBN2	1.10e-06	2	37	2	7744963
Pubmed	Fibrillin microfibrils in bone physiology.	FBN1 FBN2	1.10e-06	2	37	2	26408953
Pubmed	Arg-Gly-Asp-containing domains of fibrillins-1 and -2 distinctly regulate lung fibroblast migration.	FBN1 FBN2	1.10e-06	2	37	2	18006876
Pubmed	Interaction of tropoelastin with the amino-terminal domains of fibrillin-1 and fibrillin-2 suggests a role for the fibrillins in elastic fiber assembly.	FBN1 FBN2	3.30e-06	3	37	2	10825173
Pubmed	Cloning and mapping of members of the MYM family.	ZMYM4 ZMYM6	3.30e-06	3	37	2	10486218
Pubmed	Adamts10 inactivation in mice leads to persistence of ocular microfibrils subsequent to reduced fibrillin-2 cleavage.	FBN1 FBN2	3.30e-06	3	37	2	30201140
Pubmed	PLAA suppresses ovarian cancer metastasis via METTL3-mediated m6A modification of TRPC3 mRNA.	METTL3 TRPC3	3.30e-06	3	37	2	35869392
Pubmed	Fibrillin-1 and -2 differentially modulate endogenous TGF-β and BMP bioavailability during bone formation.	FBN1 FBN2	3.30e-06	3	37	2	20855508
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	AKAP6 ZBTB40 CASP8AP2 SIK3 CHD5	3.99e-06	225	37	5	12168954
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	KDM2B CASP8AP2 LAMC1 PHC3 CHD3 ZMYM4	4.93e-06	418	37	6	34709266
Pubmed	Latent transforming growth factor beta-binding protein 1 interacts with fibrillin and is a microfibril-associated protein.	FBN1 FBN2	6.60e-06	4	37	2	12429738
Pubmed	Human eye development is characterized by coordinated expression of fibrillin isoforms.	FBN1 FBN2	6.60e-06	4	37	2	25406291
Pubmed	Extracellular microfibrils control osteoblast-supported osteoclastogenesis by restricting TGF{beta} stimulation of RANKL production.	FBN1 FBN2	6.60e-06	4	37	2	20729550
Pubmed	Heparin/heparan sulfate controls fibrillin-1, -2 and -3 self-interactions in microfibril assembly.	FBN1 FBN2	6.60e-06	4	37	2	25034023
Pubmed	Comprehensive genetic analysis of relevant four genes in 49 patients with Marfan syndrome or Marfan-related phenotypes.	FBN1 FBN2	6.60e-06	4	37	2	16835936
Pubmed	Adamts18 Deficiency Causes Spontaneous SMG Fibrogenesis in Adult Mice.	LAMC1 FBN1 FBN2	8.40e-06	37	37	3	34323105
Pubmed	Characterization of Microfibrillar-associated Protein 4 (MFAP4) as a Tropoelastin- and Fibrillin-binding Protein Involved in Elastic Fiber Formation.	FBN1 FBN2	1.10e-05	5	37	2	26601954
Pubmed	Fibrillin-1 interactions with fibulins depend on the first hybrid domain and provide an adaptor function to tropoelastin.	FBN1 FBN2	1.10e-05	5	37	2	17255108
Pubmed	POGLUT2 and POGLUT3 O-glucosylate multiple EGF repeats in fibrillin-1, -2, and LTBP1 and promote secretion of fibrillin-1.	FBN1 FBN2	1.10e-05	5	37	2	34411563
Pubmed	Relaxin regulates fibrillin 2, but not fibrillin 1, mRNA and protein expression by human dermal fibroblasts and murine fetal skin.	FBN1 FBN2	1.10e-05	5	37	2	12590922
Pubmed	Development, composition, and structural arrangements of the ciliary zonule of the mouse.	FBN1 FBN2	1.10e-05	5	37	2	23493297
Pubmed	Human transcription factor protein interaction networks.	ZBTB40 KDM2B SLU7 PHC3 CHD3 FBN1 FBN2 ZMYM4 CHD5	1.43e-05	1429	37	9	35140242
Pubmed	Of mice and Marfan: genetic linkage analyses of the fibrillin genes, Fbn1 and Fbn2, in the mouse genome.	FBN1 FBN2	1.65e-05	6	37	2	7873879
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	AKAP6 KDM2B CASP8AP2 SIK3 ZMYM4 CHD5	1.88e-05	529	37	6	14621295
Pubmed	Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance.	LAMC1 FBN1 FBN2	2.10e-05	50	37	3	23658023
Pubmed	The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver.	ALB SIK3	2.30e-05	7	37	2	25088745
Pubmed	Regulation of limb patterning by extracellular microfibrils.	FBN1 FBN2	2.30e-05	7	37	2	11470817
Pubmed	Characterization of cDNA clones in size-fractionated cDNA libraries from human brain.	ZBTB40 CHD5 RABGAP1L	2.96e-05	56	37	3	9455484
Pubmed	Putative functions of extracellular matrix glycoproteins in secondary palate morphogenesis.	FBN1 FBN2	3.07e-05	8	37	2	23055981
Pubmed	Adamts17 is involved in skeletogenesis through modulation of BMP-Smad1/5/8 pathway.	FBN1 FBN2	3.07e-05	8	37	2	31201465
Pubmed	EMILIN proteins are novel extracellular constituents of the dentin-pulp complex.	LAMC1 FBN1	3.07e-05	8	37	2	32948785
Pubmed	Targeting of bone morphogenetic protein growth factor complexes to fibrillin.	FBN1 FBN2	3.07e-05	8	37	2	18339631
Pubmed	Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.	LAMC1 FBN1 FBN2 ADAM10	3.59e-05	175	37	4	28071719
Pubmed	Microfibril-associated glycoprotein-2 interacts with fibrillin-1 and fibrillin-2 suggesting a role for MAGP-2 in elastic fiber assembly.	FBN1 FBN2	3.95e-05	9	37	2	12122015
Pubmed	Poglut2/3 double knockout in mice results in neonatal lethality with reduced levels of fibrillin in lung tissues.	FBN1 FBN2	3.95e-05	9	37	2	38844137
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	ZBTB40 KDM2B PHC3 CHD3 ZMYM4 CHD5	4.08e-05	608	37	6	36089195
Pubmed	Hypermethylation of UCHL1 Promotes Metastasis of Nasopharyngeal Carcinoma by Suppressing Degradation of Cortactin (CTTN).	ANKRD31 METTL3 ALB	4.63e-05	65	37	3	32120844
Pubmed	Limb- and tendon-specific Adamtsl2 deletion identifies a role for ADAMTSL2 in tendon growth in a mouse model for geleophysic dysplasia.	FBN1 FBN2	4.93e-05	10	37	2	30738849
Pubmed	Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation.	LAMC1 FBN1 FBN2	6.03e-05	71	37	3	33541421
Pubmed	Disruption of murine Adamtsl4 results in zonular fiber detachment from the lens and in retinal pigment epithelium dedifferentiation.	FBN1 FBN2	7.22e-05	12	37	2	26405179
Pubmed	A distinct transcriptome characterizes neural crest-derived cells at the migratory wavefront during enteric nervous system development.	FBN1 FBN2	7.22e-05	12	37	2	36779913
Pubmed	DLX1 and the NuRD complex cooperate in enhancer decommissioning and transcriptional repression.	CHD3 CHD5	1.15e-04	15	37	2	35695185
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	AKAP6 ZBTB40 SLU7 PHC3 CHD3 OSBPL3 QSOX2	1.27e-04	1084	37	7	11544199
Pubmed	A Functional Switch of NuRD Chromatin Remodeling Complex Subunits Regulates Mouse Cortical Development.	CHD3 CHD5	1.48e-04	17	37	2	27806305
Pubmed	Proteolysis of fibrillin-2 microfibrils is essential for normal skeletal development.	FBN1 FBN2	1.67e-04	18	37	2	35503090
Pubmed	NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency.	CHD3 ZMYM4 CHD5	1.82e-04	103	37	3	32744500
Pubmed	Interaction proteomics analysis of polycomb proteins defines distinct PRC1 complexes in mammalian cells.	PHC3 ZMYM4 CCDC158	2.59e-04	116	37	3	21282530
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	FBN2 SIK3 ZNF565 STXBP2 GGA1 OSBPL3	2.60e-04	853	37	6	28718761
Pubmed	A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.	SLU7 FBN1 FBN2 QSOX2	2.79e-04	298	37	4	32353859
Pubmed	ERp57 is essential for efficient folding of glycoproteins sharing common structural domains.	LAMC1 ADAM10	3.25e-04	25	37	2	17170699
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	KDM2B CASP8AP2 METTL3 ZMYM4 ZMYM6	3.79e-04	588	37	5	38580884
Pubmed	MxA interacts with and is modified by the SUMOylation machinery.	CASP8AP2 CHD3	3.80e-04	27	37	2	25447205
Pubmed	Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.	LAMC1 FBN1 FBN2	4.03e-04	135	37	3	28675934
Pubmed	Identification and characterization of a set of conserved and new regulators of cytoskeletal organization, cell morphology and migration.	ZMYM4 ZMYM6	4.39e-04	29	37	2	21834987
Pubmed	ADAMTS18 Deficiency Leads to Pulmonary Hypoplasia and Bronchial Microfibril Accumulation.	FBN1 FBN2	4.70e-04	30	37	2	32882513
Pubmed	Heritable Thoracic Aortic Disease Overview	FBN1 FBN2	4.70e-04	30	37	2	20301299
Pubmed	Adamtsl2 deletion results in bronchial fibrillin microfibril accumulation and bronchial epithelial dysplasia--a novel mouse model providing insights into geleophysic dysplasia.	FBN1 FBN2	5.02e-04	31	37	2	25762570
Pubmed	Association of mitotic regulation pathway polymorphisms with pancreatic cancer risk and outcome.	SIK3 TEX14	5.35e-04	32	37	2	20056645
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	KDM2B SLU7 LAMC1 SIK3 ZNF442	5.49e-04	638	37	5	31182584
Pubmed	Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.	CASP8AP2 ZMYM6 CHD5	5.81e-04	153	37	3	10718198
Pubmed	The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1.	KDM2B PHC3 CHD3	6.26e-04	157	37	3	30186101
Pubmed	Identification of the BRD1 interaction network and its impact on mental disorder risk.	CHD3 CHD5	6.41e-04	35	37	2	27142060
Pubmed	O-fucosylation of thrombospondin type 1 repeats is essential for ECM remodeling and signaling during bone development.	FBN1 FBN2	6.78e-04	36	37	2	35167946
Pubmed	USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities.	ANKRD31 FBN1 FBN2 ZXDA PRSS27	7.03e-04	674	37	5	37196079
Pubmed	The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices.	LAMC1 FBN1 ADAM10	7.49e-04	167	37	3	22159717
Pubmed	Linking functions: an additional role for an intrinsically disordered linker domain in the transcriptional coactivator CBP.	CASP8AP2 CHD3	7.56e-04	38	37	2	28680062
Pubmed	Cross-linking mass spectrometry reveals the structural topology of peripheral NuRD subunits relative to the core complex.	CHD3 CHD5	7.56e-04	38	37	2	33283408
Pubmed	Fibrillin-2 is a key mediator of smooth muscle extracellular matrix homeostasis during mouse tracheal tubulogenesis.	FBN1 FBN2	8.37e-04	40	37	2	30578393
Pubmed	PCGF homologs, CBX proteins, and RYBP define functionally distinct PRC1 family complexes.	KDM2B PHC3	8.80e-04	41	37	2	22325352
Pubmed	Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.	ALB FBN1 FBN2	9.92e-04	184	37	3	32908313
GeneFamily	Zinc fingers MYM-type	ZMYM4 ZMYM6	2.31e-05	6	23	2	86
GeneFamily	PHD finger proteins\|NuRD complex	CHD3 CHD5	1.01e-04	12	23	2	1305
GeneFamily	PHD finger proteins	KDM2B CHD3 CHD5	1.97e-04	90	23	3	88
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZBTB40 ZNF565 ZNF442 ZXDA	1.20e-02	718	23	4	28
Disease	connective tissue disease (implicated_via_orthology)	FBN1 FBN2	4.34e-06	3	36	2	DOID:65 (implicated_via_orthology)
Disease	scoliosis (is_implicated_in)	FBN1 FBN2	8.67e-06	4	36	2	DOID:0060249 (is_implicated_in)
Disease	ascending aortic diameter	FBN1 FBN2 HYDIN DLEU1	2.54e-05	140	36	4	EFO_0021787
Disease	Marfan Syndrome, Type I	LAMC1 FBN1	5.18e-05	9	36	2	C4721845
Disease	Marfan Syndrome	LAMC1 FBN1	7.90e-05	11	36	2	C0024796
Disease	level of Phosphatidylethanolamine (18:1_18:1) in blood serum	SIK3 ADAM10	1.30e-04	14	36	2	OBA_2045142
Disease	descending aortic diameter	FBN1 SIK3 TRPC3	1.70e-04	88	36	3	EFO_0021788
Disease	Colorectal Carcinoma	AKAP6 LAMC1 FBN2 ZNF442 ZMYM4 CHD5	1.88e-04	702	36	6	C0009402
Disease	amblyopia	MALRD1 CNGB1	3.29e-04	22	36	2	MONDO_0001020
Disease	level of Phosphatidylethanolamine (16:0_18:2) in blood serum	SIK3 ADAM10	3.93e-04	24	36	2	OBA_2045136
Disease	colorectal cancer	AKAP6 ZBTB40 LAMC1 FBN1 OSBPL3	7.88e-04	604	36	5	MONDO_0005575
Disease	unipolar depression, bipolar disorder	KDM2B OSBPL3 DLEU1	9.11e-04	156	36	3	EFO_0003761, MONDO_0004985
Disease	sleep apnea	KDM2B DLEU1	1.10e-03	40	36	2	EFO_0003877
Disease	cholesteryl esters to total lipids in small HDL percentage	SIK3 ADAM10	1.27e-03	43	36	2	EFO_0022254
Disease	heel bone mineral density, urate measurement	ANKRD31 OSBPL3 DLEU1	1.42e-03	182	36	3	EFO_0004531, EFO_0009270

Protein segments in the cluster

Peptide	Gene	Start	Entry
VMDDFAAFVEKCCKA	ALB	571	P02768
EEDDHMEFCRVCKDG	CHD5	411	Q8TDI0
DGKDDKELCHVCCMK	ADAM10	586	O14672
KMGHSDEVADECFKL	CASP8AP2	1636	Q9UKL3
YCGDKTCMHTVSDKD	CHML	181	P26374
CKECGEHFEEMAKES	QSOX2	476	Q6ZRP7
DDGKCALDEAKDLCM	ANKRD31	586	Q8N7Z5
KYQMGDCCKEEIDDS	DLEU1	61	O43261
ETCMKSCGKRFHDEV	GGA1	71	Q9UJY5
EEMDSELLKCEFCGK	PHC3	776	Q8NDX5
CDYGTKEECMKASDA	METTL3	276	Q86U44
MACKHCSDIFSKEGA	RABGAP1L	141	B7ZAP0
DHEFMCANKHCIAKD	MALRD1	1266	Q5VYJ5
DCVADAMGKCEEFIA	HYDIN	3286	Q4G0P3
RTECGECHFCKDMKK	KDM2B	621	Q8NHM5
VDMDECKEPDVCKHG	FBN1	2126	P35555
CEEGKHDCTEKQMEC	FBN1	2251	P35555
EEDDHMEYCRVCKDG	CHD3	451	Q12873
HASECMKNEFDKLVC	LAMC1	291	P11047
FEEASGKKICEHDSM	CCDC158	196	Q5M9N0
MCKDLDECAEGLHDC	FBN2	2291	P35556
SEDMEKCSKDLAHCH	OSBPL3	216	Q9H4L5
KDCEMEKCPDSCAHE	PRR14L	1141	Q5THK1
DKMEREACCFGSEDE	TEX14	671	Q8IWB6
HSESMEEDCSCEGAK	SIK3	1091	Q9Y2K2
EISESEHCKCKALMD	AKAP6	1926	Q13023
EHCKCKALMDSLDDS	AKAP6	1931	Q13023
VEEEHYCDMLCCKFK	CNGB1	621	Q14028
ETGEKLMECHECGKA	ZNF565	201	Q8N9K5
DMLCAGFEEGKKDAC	PRSS27	211	Q9BQR3
DDCMKHFKGSVEKLC	STXBP2	351	Q15833
TCQMCGEKFLKHSDE	TSPAN31	156	Q12999
ENCGAMTHKKKDCFE	SLU7	121	O95391
EKTHTGEKMHECKEC	ZNF442	591	Q9H7R0
MKGHEQENSFKCEVC	ZXDA	351	P98168
KLEEFCCEDCMSKFT	ZMYM6	536	O95789
GGKVEEFCCEECMSK	ZMYM4	791	Q5VZL5
FCKCGDCMEKQRHDS	TRPC3	181	Q13507
KAEHADMKFHECDQC	ZBTB40	1066	Q9NUA8
DMKFHECDQCKELFP	ZBTB40	1071	Q9NUA8