Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionWnt receptor activity

FZD7 FZD2 FZD3

7.61e-0617463GO:0042813
GeneOntologyMolecularFunctionWnt-protein binding

FZD7 FZD2 FZD3

6.51e-0534463GO:0017147
GeneOntologyBiologicalProcesstissue morphogenesis

TXNRD1 WT1 MST1 FLNA TSC2 MST1L FZD2 FZD3 SMAD7

3.49e-05750469GO:0048729
GeneOntologyBiologicalProcesspositive regulation of transforming growth factor beta1 production

THBS1 LUM

7.26e-056462GO:0032914
GeneOntologyBiologicalProcessnegative regulation of heterochromatin formation

RLF PHF2

7.26e-056462GO:0031452
GeneOntologyBiologicalProcessregulation of macrophage chemotaxis

MST1 THBS1 MST1L

7.65e-0537463GO:0010758
GeneOntologyBiologicalProcessnegative regulation of chromatin organization

RLF PHF2

1.01e-047462GO:1905268
GeneOntologyBiologicalProcesspositive regulation of mammary gland epithelial cell proliferation

MST1 MST1L

1.73e-049462GO:0033601
GeneOntologyBiologicalProcessmammary duct terminal end bud growth

MST1 MST1L

1.73e-049462GO:0060763
GeneOntologyBiologicalProcessWnt signaling pathway, planar cell polarity pathway

FZD7 FZD2 FZD3

2.51e-0455463GO:0060071
GeneOntologyBiologicalProcessregulation of macrophage migration

MST1 THBS1 MST1L

2.65e-0456463GO:1905521
GeneOntologyBiologicalProcessmacrophage chemotaxis

MST1 THBS1 MST1L

2.65e-0456463GO:0048246
GeneOntologyBiologicalProcessregulation of transforming growth factor beta1 production

THBS1 LUM

3.17e-0412462GO:0032908
GeneOntologyBiologicalProcessepithelial tube morphogenesis

WT1 MST1 TSC2 MST1L FZD2 FZD3

3.28e-04421466GO:0060562
GeneOntologyBiologicalProcesstransforming growth factor beta1 production

THBS1 LUM

3.74e-0413462GO:0032905
GeneOntologyBiologicalProcessmorphogenesis of an epithelium

WT1 MST1 FLNA TSC2 MST1L FZD2 FZD3

4.10e-04619467GO:0002009
DomainFrizzled

FZD7 FZD2 FZD3

1.99e-0611443IPR000539
DomainFrizzled

FZD7 FZD2 FZD3

1.99e-0611443PF01534
DomainFrizzled

FZD7 FZD2 FZD3

1.99e-0611443SM01330
DomainFrizzled/SFRP

FZD7 FZD2 FZD3

6.69e-0616443IPR015526
DomainFRI

FZD7 FZD2 FZD3

1.35e-0520443SM00063
Domain-

FZD7 FZD2 FZD3

1.58e-05214431.10.2000.10
DomainFrizzled_dom

FZD7 FZD2 FZD3

2.39e-0524443IPR020067
DomainFZ

FZD7 FZD2 FZD3

2.39e-0524443PS50038
DomainFz

FZD7 FZD2 FZD3

2.39e-0524443PF01392
DomainPAN_AP

MST1 MST1L

5.40e-055442SM00473
DomainPAN

MST1 MST1L

1.13e-047442PS50948
DomainPan_app

MST1 MST1L

1.13e-047442IPR003609
DomainPAN_1

MST1 MST1L

1.13e-047442PF00024
DomainGPCR_2_secretin-like

FZD7 FZD2 FZD3

3.80e-0460443IPR000832
DomainGPCR_2-like

FZD7 FZD2 FZD3

3.80e-0460443IPR017981
DomainG_PROTEIN_RECEP_F2_4

FZD7 FZD2 FZD3

3.99e-0461443PS50261
DomainKringle

MST1 MST1L

7.21e-0417442IPR000001
DomainKringle_CS

MST1 MST1L

7.21e-0417442IPR018056
DomainKRINGLE_2

MST1 MST1L

7.21e-0417442PS50070
DomainKringle

MST1 MST1L

7.21e-0417442PF00051
DomainKRINGLE_1

MST1 MST1L

7.21e-0417442PS00021
DomainKR

MST1 MST1L

7.21e-0417442SM00130
DomainKringle-like

MST1 MST1L

2.57e-0332442IPR013806
PathwayKEGG_MEDICUS_REFERENCE_WNT_SIGNALING_MODULATION_SOST_LRP4

FZD7 FZD2 FZD3

5.94e-0614373M47834
PathwayKEGG_MEDICUS_REFERENCE_WNT5A_ROR_SIGNALING_PATHWAY

FZD7 FZD2 FZD3

9.10e-0616373M47823
PathwayKEGG_MEDICUS_REFERENCE_WNT_SIGNALING_MODULATION_LGR_RSPO

FZD7 FZD2 FZD3

1.57e-0519373M47833
PathwayWP_POLYCYSTIC_KIDNEY_DISEASE_PATHWAY

FZD7 TSC2 FZD2 FZD3

6.99e-0585374M48315
PathwayPID_WNT_NONCANONICAL_PATHWAY

FZD7 FLNA FZD2

7.83e-0532373M23
PathwayREACTOME_SIGNALING_BY_MST1

MST1 MST1L

9.99e-056372MM15492
PathwayWP_WNT_SIGNALING_IN_KIDNEY_DISEASE

FZD7 FZD2 FZD3

1.12e-0436373M39699
PathwayBIOCARTA_MSP_PATHWAY

MST1 MST1L

1.40e-047372MM1580
PathwayWP_MIR302367_PROMOTING_CARDIOMYOCYTE_PROLIFERATION

MST1 MST1L

1.86e-048372MM15986
PathwayWP_WNT_SIGNALING_IN_KIDNEY_DISEASE

FZD7 FZD2 FZD3

2.05e-0444373MM15878
PathwayKEGG_MEDICUS_VARIANT_LRP6_OVEREXPRESSION_TO_WNT_SIGNALING_PATHWAY

FZD7 FZD2 FZD3

2.19e-0445373M47412
PathwayWP_ESC_PLURIPOTENCY_PATHWAYS

FZD7 FZD2 FZD3 SMAD7

2.33e-04116374MM15863
PathwayKEGG_MEDICUS_REFERENCE_WNT_SIGNALING_PATHWAY

FZD7 FZD2 FZD3

2.34e-0446373M47409
PathwayWP_EMBRYONIC_STEM_CELL_PLURIPOTENCY_PATHWAYS

FZD7 FZD2 FZD3 SMAD7

2.41e-04117374M39530
PathwayKEGG_BASAL_CELL_CARCINOMA

FZD7 FZD2 FZD3

3.98e-0455373M17807
PathwayREACTOME_ASYMMETRIC_LOCALIZATION_OF_PCP_PROTEINS

FZD7 FZD2 FZD3

5.14e-0460373MM15150
PathwayWP_WNT_SIGNALING

FZD7 FZD2 FZD3

5.39e-0461373MM15893
PathwayREACTOME_ASYMMETRIC_LOCALIZATION_OF_PCP_PROTEINS

FZD7 FZD2 FZD3

6.21e-0464373M27396
PathwayWP_PHYSICOCHEMICAL_FEATURES_AND_TOXICITYASSOCIATED_PATHWAYS

FZD7 FZD2 FZD3

6.80e-0466373M39642
PathwayREACTOME_PCP_CE_PATHWAY

FZD7 FZD2 FZD3

1.42e-0385373MM15041
PathwayWP_NCRNAS_INVOLVED_IN_WNT_SIGNALING_IN_HEPATOCELLULAR_CARCINOMA

FZD7 FZD2 FZD3

1.62e-0389373M39563
PathwayWNT_SIGNALING

FZD7 FZD2 FZD3

1.62e-0389373M5493
PathwayREACTOME_PCP_CE_PATHWAY

FZD7 FZD2 FZD3

1.78e-0392373M27322
PathwayREACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS

FZD7 FZD2 FZD3

1.89e-0394373M797
PathwayWP_LNCRNA_IN_CANONICAL_WNT_SIGNALING_AND_COLORECTAL_CANCER

FZD7 FZD2 FZD3

2.13e-0398373M39731
PathwayKEGG_MELANOGENESIS

FZD7 FZD2 FZD3

2.32e-03101373M7761
PathwayWP_WNT_SIGNALING_PATHWAY_AND_PLURIPOTENCY

FZD7 FZD2 FZD3

2.32e-03101373MM15829
PathwayWP_WNT_SIGNALING_AND_PLURIPOTENCY

FZD7 FZD2 FZD3

2.32e-03101373M39387
PathwayPID_WNT_SIGNALING_PATHWAY

FZD7 FZD2

2.43e-0328372M77
PathwayPID_SYNDECAN_4_PATHWAY

FZD7 THBS1

3.16e-0332372M165
PathwayWP_WNT_SIGNALING_WP428

FZD7 FZD2 FZD3

3.20e-03113373M39669
PathwayWP_OSTEOBLAST_DIFFERENTIATION_AND_RELATED_DISEASES

FZD7 FZD2 FZD3

3.61e-03118373M39852
Pubmed

Direct interaction between NHERF1 and Frizzled regulates β-catenin signaling.

FZD7 FZD2 FZD3

4.32e-08646320802536
Pubmed

Sequence requirement and subtype specificity in the high-affinity interaction between human frizzled and dishevelled proteins.

FZD7 FZD2 FZD3

1.21e-07846319388021
Pubmed

Expression of Frizzled genes in developing and postnatal hair follicles.

FZD7 FZD2 FZD3

2.58e-071046315245425
Pubmed

Essential roles of mesenchyme-derived beta-catenin in mouse Müllerian duct morphogenesis.

FZD7 FZD2 FZD3

2.58e-071046317532316
Pubmed

Frizzled-9 impairs acetylcholine receptor clustering in skeletal muscle cells.

FZD7 FZD2 FZD3

3.55e-071146324860427
Pubmed

Molecular determinants of WNT9b responsiveness in nephron progenitor cells.

FZD7 FZD2 FZD3

3.55e-071146330978219
Pubmed

Distinct but redundant expression of the Frizzled Wnt receptor genes at signaling centers of the developing mouse brain.

FZD7 FZD2 FZD3

3.55e-071146317582687
Pubmed

Expression of Frizzled5, Frizzled7, and Frizzled10 during early mouse development and interactions with canonical Wnt signaling.

FZD7 FZD2 FZD3

3.55e-071146317576136
Pubmed

Dickkopf-1 (DKK1) reveals that fibronectin is a major target of Wnt signaling in branching morphogenesis of the mouse embryonic lung.

FZD7 FZD2 FZD3

9.74e-071546315617677
Pubmed

Mst1 regulates post-infarction cardiac injury through the JNK-Drp1-mitochondrial fission pathway.

MST1 MST1L

1.71e-06246229760744
Pubmed

Cloning, sequencing, and expression of human macrophage stimulating protein (MSP, MST1) confirms MSP as a member of the family of kringle proteins and locates the MSP gene on chromosome 3.

MST1 MST1L

1.71e-0624628393443
Pubmed

MSP is a negative regulator of inflammation and lipogenesis in ex vivo models of non-alcoholic steatohepatitis.

MST1 MST1L

1.71e-06246227609031
Pubmed

Hepatocyte growth factor-like protein is required for prostate tumor growth in the TRAMP mouse model.

MST1 MST1L

1.71e-06246224980820
Pubmed

Mst1 deletion reduces hyperglycemia-mediated vascular dysfunction via attenuating mitochondrial fission and modulating the JNK signaling pathway.

MST1 MST1L

1.71e-06246231206688
Pubmed

Structure of the human D1F15S1A locus: a chromosome 1 locus with 97% identity to the chromosome 3 gene coding for hepatocyte growth factor-like protein.

MST1 MST1L

1.71e-06246210728827
Pubmed

Genetically selected Marchigian Sardinian alcohol-preferring (msP) rats: an animal model to study the neurobiology of alcoholism.

MST1 MST1L

1.71e-06246216961763
Pubmed

Inhibiting endothelial cell Mst1 attenuates acute lung injury in mice.

MST1 MST1L

1.71e-06246239253972
Pubmed

Cerebral ischemia-reperfusion is modulated by macrophage-stimulating 1 through the MAPK-ERK signaling pathway.

MST1 MST1L

1.71e-06246232017081
Pubmed

Mst1 inhibition attenuates non-alcoholic fatty liver disease via reversing Parkin-related mitophagy.

MST1 MST1L

1.71e-06246230708325
Pubmed

Functional consequences of the macrophage stimulating protein 689C inflammatory bowel disease risk allele.

MST1 MST1L

1.71e-06246224409221
Pubmed

Melatonin alleviates postinfarction cardiac remodeling and dysfunction by inhibiting Mst1.

MST1 MST1L

1.71e-06246227696525
Pubmed

Hepatocyte-specific expression of the mouse hepatocyte growth factor-like protein.

MST1 MST1L

1.71e-0624628340069
Pubmed

Biological effects of targeted inactivation of hepatocyte growth factor-like protein in mice.

MST1 MST1L

1.71e-0624629486989
Pubmed

Treatment with XMU-MP-1 erases hyperglycaemic memory in hearts of diabetic mice.

MST1 MST1L

1.71e-06246233887258
Pubmed

HGFL supports mammary tumorigenesis by enhancing tumor cell intrinsic survival and influencing macrophage and T-cell responses.

MST1 MST1L

1.71e-06246225938541
Pubmed

Assignment of 22 loci in the rat by somatic hybrid and linkage analysis.

WT1 MST1 MST1L

1.74e-06184638268657
Pubmed

Regulation of angiogenesis by a non-canonical Wnt-Flt1 pathway in myeloid cells.

FZD7 FZD2 FZD3

2.07e-061946321623369
Pubmed

Motor neurons with axial muscle projections specified by Wnt4/5 signaling.

FZD7 FZD2 FZD3

3.28e-062246319285468
Pubmed

Expression of the Wnt inhibitor Dickkopf-1 is required for the induction of neural markers in mouse embryonic stem cells differentiating in response to retinoic acid.

FZD7 FZD2 FZD3

3.28e-062246317064353
Pubmed

A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors.

FZD7 FZD2 FZD3

4.30e-06244639096311
Pubmed

A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled.

FZD7 FZD2 FZD3

4.30e-06244638626800
Pubmed

A role for Wnt/beta-catenin signaling in lens epithelial differentiation.

FZD7 FZD2 FZD3

4.88e-062546312812787
Pubmed

Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7.

FZD7 FZD2

5.13e-0634629813155
Pubmed

The Ron/STK receptor tyrosine kinase is essential for peri-implantation development in the mouse.

MST1 MST1L

5.13e-06346210225971
Pubmed

Inhibition of MST1 ameliorates neuronal apoptosis via GSK3β/β-TrCP/NRF2 pathway in spinal cord injury accompanied by diabetes.

MST1 MST1L

5.13e-06346238430683
Pubmed

Macrophage stimulating protein is a target-derived neurotrophic factor for developing sensory and sympathetic neurons.

MST1 MST1L

5.13e-06346212538524
Pubmed

Mst1 controls lymphocyte trafficking and interstitial motility within lymph nodes.

MST1 MST1L

5.13e-06346219339990
Pubmed

TRAF2 functions as an activator switch in the reactive oxygen species-induced stimulation of MST1.

MST1 MST1L

5.13e-06346226698664
Pubmed

Melatonin activates Parkin translocation and rescues the impaired mitophagy activity of diabetic cardiomyopathy through Mst1 inhibition.

MST1 MST1L

5.13e-06346230063115
Pubmed

Mst1-mediated phosphorylation of Bcl-xL is required for myocardial reperfusion injury.

MST1 MST1L

5.13e-06346227218122
Pubmed

Frizzled proteins are colonic epithelial receptors for C. difficile toxin B.

FZD7 FZD2

5.13e-06346227680706
Pubmed

Inhibition of endogenous Mst1 prevents apoptosis and cardiac dysfunction without affecting cardiac hypertrophy after myocardial infarction.

MST1 MST1L

5.13e-06346217395874
Pubmed

Genetic deletion of Mst1 alters T cell function and protects against autoimmunity.

MST1 MST1L

5.13e-06346224852423
Pubmed

Mst1 participates in the atherosclerosis progression through macrophage autophagy inhibition and macrophage apoptosis enhancement.

MST1 MST1L

5.13e-06346227496379
Pubmed

Macrophage-stimulating protein cooperates with erythropoietin to induce colony formation and MAP kinase activation in primary erythroid progenitor cells.

MST1 MST1L

5.13e-06346212804176
Pubmed

Receptor tyrosine kinase Ron is expressed in mouse reproductive tissues during embryo implantation and is important in trophoblast cell function.

MST1 MST1L

5.13e-06346212606483
Pubmed

Mst1-mediated phosphorylation of Nur77 improves the endometrial receptivity in human and mice.

MST1 MST1L

5.13e-06346236623453
Pubmed

Hippo Kinase MST1-Mediated Cell Metabolism Reprograms the Homeostasis and Differentiation of Granulocyte Progenitor Cells.

MST1 MST1L

5.13e-06346237184367
Pubmed

CircRbms1 fosters MST1 mRNA and protein levels to motivate myocardial ischaemia-reperfusion injury via autophagic status.

MST1 MST1L

5.13e-06346238288506
Pubmed

The proto-oncogene RON is involved in development of epithelial, bone and neuro-endocrine tissues.

MST1 MST1L

5.13e-0634628545120
Pubmed

Hepatocyte growth factor-like protein is a positive regulator of early mammary gland ductal morphogenesis.

MST1 MST1L

5.13e-06346225049204
Pubmed

Characterization of the mouse cDNA and gene coding for a hepatocyte growth factor-like protein: expression during development.

MST1 MST1L

5.13e-0634621832957
Pubmed

Activation of pro-survival CaMK4β/CREB and pro-death MST1 signaling at early and late times during a mouse model of prion disease.

MST1 MST1L

5.13e-06346225183307
Pubmed

MST1 mediates neuronal loss and cognitive deficits: A novel therapeutic target for Alzheimer's disease.

MST1 MST1L

5.13e-06346235525373
Pubmed

MST1 coordinately regulates autophagy and apoptosis in diabetic cardiomyopathy in mice.

MST1 MST1L

5.13e-06346227510910
Pubmed

Combination of melatonin and irisin ameliorates lipopolysaccharide-induced cardiac dysfunction through suppressing the Mst1-JNK pathways.

MST1 MST1L

5.13e-06346231976559
Pubmed

Over-expressed MST1 impaired spatial memory via disturbing neural oscillation patterns in mice.

MST1 MST1L

5.13e-06346232468668
Pubmed

Nicorandil alleviates myocardial injury and post-infarction cardiac remodeling by inhibiting Mst1.

MST1 MST1L

5.13e-06346229127009
Pubmed

Mst1 Kinase Regulates the Actin-Bundling Protein L-Plastin To Promote T Cell Migration.

MST1 MST1L

5.13e-06346227465533
Pubmed

Suramin protects hepatocytes from LPS-induced apoptosis by regulating mitochondrial stress and inactivating the JNK-Mst1 signaling pathway.

MST1 MST1L

5.13e-06346230771091
Pubmed

MST1 mediates the N-methyl-D-aspartate-induced excitotoxicity in mouse cortical neurons.

MST1 MST1L

5.13e-06346234967918
Pubmed

Hippo kinases Mst1 and Mst2 maintain NK cell homeostasis by orchestrating metabolic state and transcriptional activity.

MST1 MST1L

5.13e-06346238898027
Pubmed

WASP and Mst1 coregulate B-cell development and B-cell receptor signaling.

MST1 MST1L

5.13e-06346232045478
Pubmed

Impaired liver regeneration in aged mice can be rescued by silencing Hippo core kinases MST1 and MST2.

MST1 MST1L

5.13e-06346227940445
Pubmed

3D representation of Wnt and Frizzled gene expression patterns in the mouse embryo at embryonic day 11.5 (Ts19).

FZD7 FZD2 FZD3

7.72e-062946318364260
Pubmed

Inhibition of TLR4-induced IκB kinase activity by the RON receptor tyrosine kinase and its ligand, macrophage-stimulating protein.

MST1 MST1L

1.03e-05446221078906
Pubmed

MST1 controls murine neutrophil homeostasis via the G-CSFR/STAT3 axis.

MST1 MST1L

1.03e-05446236618429
Pubmed

Hyperglycemia-Induced Overexpression of PH Domain Leucine-Rich Repeat Protein Phosphatase 1 (PHLPP1) Compromises the Cardioprotective Effect of Ischemic Postconditioning Via Modulation of the Akt/Mst1 Pathway Signaling.

MST1 MST1L

1.03e-05446235715527
Pubmed

Rab13 acts downstream of the kinase Mst1 to deliver the integrin LFA-1 to the cell surface for lymphocyte trafficking.

MST1 MST1L

1.03e-05446225074980
Pubmed

OSM mitigates post-infarction cardiac remodeling and dysfunction by up-regulating autophagy through Mst1 suppression.

MST1 MST1L

1.03e-05446227825852
Pubmed

MST1 deficiency promotes B cell responses by CD4+ T cell-derived IL-4, resulting in hypergammaglobulinemia.

MST1 MST1L

1.03e-05446228527887
Pubmed

Mst1 directs Myosin IIa partitioning of low and higher affinity integrins during T cell migration.

MST1 MST1L

1.03e-05446225133611
Pubmed

LncRNA SNHG17 knockdown promotes Parkin-dependent mitophagy and reduces apoptosis of podocytes through Mst1.

MST1 MST1L

1.03e-05446232627655
Pubmed

Macrophage MST1/2 Disruption Impairs Post-Infarction Cardiac Repair via LTB4.

MST1 MST1L

1.03e-05446234515499
Pubmed

Ror2 modulates the canonical Wnt signaling in lung epithelial cells through cooperation with Fzd2.

FZD7 FZD2

1.03e-05446218215320
Pubmed

The Mst1 and Mst2 kinases control activation of rho family GTPases and thymic egress of mature thymocytes.

MST1 MST1L

1.03e-05446222412158
Pubmed

Functional role of Mst1/Mst2 in embryonic stem cell differentiation.

MST1 MST1L

1.03e-05446224224013
Pubmed

Mst1 regulates hepatic lipid metabolism by inhibiting Sirt1 ubiquitination in mice.

MST1 MST1L

1.03e-05446226903296
Pubmed

Glyceraldehyde-3-phosphate dehydrogenase interacts with proapoptotic kinase mst1 to promote cardiomyocyte apoptosis.

MST1 MST1L

1.03e-05446223527007
Pubmed

A cell-intrinsic role for Mst1 in regulating thymocyte egress.

MST1 MST1L

1.03e-05446219692642
Pubmed

Melatonin protects against diabetic cardiomyopathy through Mst1/Sirt3 signaling.

MST1 MST1L

1.03e-05446228480597
Pubmed

Spatiotemporal regulation of the kinase Mst1 by binding protein RAPL is critical for lymphocyte polarity and adhesion.

MST1 MST1L

1.03e-05446216892067
Pubmed

Hippo signaling pathway reveals a spatio-temporal correlation with the size of primordial follicle pool in mice.

MST1 MST1L

1.03e-05446225659841
Pubmed

Mammalian Sterile 20-like Kinase 1 (Mst1) Enhances the Stability of Forkhead Box P3 (Foxp3) and the Function of Regulatory T Cells by Modulating Foxp3 Acetylation.

MST1 MST1L

1.03e-05446226538561
Pubmed

MST1 functions as a key modulator of neurodegeneration in a mouse model of ALS.

MST1 MST1L

1.03e-05446223818595
Pubmed

RON (MST1R) and HGFL (MST1) Co-Overexpression Supports Breast Tumorigenesis through Autocrine and Paracrine Cellular Crosstalk.

MST1 MST1L

1.03e-05446235626096
Pubmed

Mammalian sterile 20-like kinase 1 suppresses lymphoma development by promoting faithful chromosome segregation.

MST1 MST1L

1.03e-05446222926556
Pubmed

Treatment with Mammalian Ste-20-like Kinase 1/2 (MST1/2) Inhibitor XMU-MP-1 Improves Glucose Tolerance in Streptozotocin-Induced Diabetes Mice.

MST1 MST1L

1.03e-05446232987643
Pubmed

The Mst1 Kinase Is Required for Follicular B Cell Homing and B-1 B Cell Development.

MST1 MST1L

1.03e-05446230386341
Pubmed

A combination of SILAC and nucleotide acyl phosphate labelling reveals unexpected targets of the Rsk inhibitor BI-D1870.

MST1 MST1L

1.03e-05446227919044
Pubmed

Mst1/2 Kinases Modulate Glucose Uptake for Osteoblast Differentiation and Bone Formation.

MST1 MST1L

1.03e-05446229474739
Pubmed

mTORC2 regulates cardiac response to stress by inhibiting MST1.

MST1 MST1L

1.03e-05446225843706
Pubmed

Macrophage-stimulating protein, the ligand for the stem cell-derived tyrosine kinase/RON receptor tyrosine kinase, inhibits IL-12 production by primary peritoneal macrophages stimulated with IFN-gamma and lipopolysaccharide.

MST1 MST1L

1.03e-05446214734766
Pubmed

Thioredoxin-1 functions as a molecular switch regulating the oxidative stress-induced activation of MST1.

MST1 MST1L

1.03e-05446223085515
Pubmed

Wnt/Rspondin/β-catenin signals control axonal sorting and lineage progression in Schwann cell development.

FZD7 FZD2 FZD3

1.50e-053646324151333
Pubmed

Expression patterns of Wnts, Frizzleds, sFRPs, and misexpression in transgenic mice suggesting a role for Wnts in pancreas and foregut pattern formation.

FZD7 FZD2 FZD3

1.50e-053646312412008
Pubmed

Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis.

FZD7 FZD2 FZD3

1.63e-053746315342465
Pubmed

Patterns of Wnt/Fzd/LRP gene expression during embryonic hematopoiesis.

FZD7 FZD2 FZD3

1.63e-053746318800919
Pubmed

Mst1 regulates integrin-dependent thymocyte trafficking and antigen recognition in the thymus.

MST1 MST1L

1.71e-05546223033074
Pubmed

Assignment of the gene coding for hepatocyte growth factor-like protein to mouse chromosome 9.

MST1 MST1L

1.71e-0554621354648
GeneFamilyG protein-coupled receptors, Class F frizzled

FZD7 FZD2 FZD3

9.05e-0711333286
ToppCelltumor_Lymph_Node_/_Brain-Fibroblasts-Undetermined|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass

PLSCR4 LUM PLPPR4 CA5B ATRNL1

1.29e-061884558231e635706a296db6b6da1029a33bbc1b52478e
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

WT1 THBS1 LUM GLIS1 ATRNL1

1.39e-061914551caf726bd07fdca389e678fc16304a6ef1790423
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

WT1 THBS1 LUM GLIS1 ATRNL1

1.39e-061914553d60c46bced2984c27a1fcf2910bc38b31fb0148
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

WT1 THBS1 LUM GLIS1 ATRNL1

1.43e-061924554022f208eb5db760abd0aac782a25e8ab63efc64
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

WT1 THBS1 LUM GLIS1 ATRNL1

1.43e-061924559333aba0d04203ccccad78d82bf6359922f810a7
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PLSCR4 THBS1 LUM ATRNL1 FHL5

1.47e-061934555b602b1702283184bd3943c2a6f2290b7c37e407
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PLSCR4 THBS1 LUM ATRNL1 FHL5

1.47e-06193455c8c21eee8c6c086dc2faf416669cd4a002870fbe
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PLSCR4 THBS1 LUM ATRNL1 FHL5

1.58e-061964553a6c942e2907aa07b5e12dbf9019d18f7bfca507
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PLSCR4 THBS1 LUM ATRNL1 FHL5

1.58e-06196455bba88e91cd3e3a6f5a9b443e3a4da33c5b455e70
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FZD7 FLNA FHL5 ENTPD3

1.67e-05152454ee329249a034a969a16b26a224aa04249d67382d
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FZD7 FLNA FHL5 ENTPD3

1.67e-05152454bd1f36b436d8ab7dd8420f595b97d851eab31a38
ToppCellwk_15-18-Mesenchymal-Myofibro_&_SMC-Myofibro_2|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

FZD7 FLNA PLPPR4 ATRNL1

1.90e-05157454b9d04ee417c0d8ea0801d10f1c54e138587009fd
ToppCellfacs-Skin-Anagen-24m-Epithelial-bulge_keratinocyte|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FZD7 GDF10 FZD2 ENTPD3

2.42e-0516745478909f685ccd1321064eb0887caf9263e0e54879
ToppCellAdult-Mesenchymal-vascular_smooth_muscle_cell|Adult / Lineage, Cell type, age group and donor

FLNA PLPPR4 PLEKHG3 FHL5

2.72e-05172454c62cad0f4212d1e9ea1ec3143ad3c4e06aff0ebf
ToppCelltumor_Lymph_Node_/_Brain-Fibroblasts-COL13A1+_matrix_FBs|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass

PLSCR4 LUM PLPPR4 GDF10

2.97e-05176454510f9a14dc1c151d24d079e0cc004cdf4f86336c
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

THBS1 LUM GLIS1 ATRNL1

3.25e-05180454fdbd7c22044d9328a1e06e2f9a4451529d1df767
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

THBS1 LUM GLIS1 ATRNL1

3.25e-05180454280ff5c8f292be1b88120db5ff1788b750644856
ToppCellPND14-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

C1QTNF3 LUM GDF10 FZD2

3.32e-051814546730e249cac55ae892cc567d9211615882f3dab4
ToppCellPND14-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

C1QTNF3 LUM GDF10 FZD2

3.32e-051814543462aa1c08fbaf613b6278ab2c7a5a0940bf537d
ToppCelldroplet-Kidney-nan-21m-Mesenchymal-podocyte|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

WT1 LUM FZD2 FZD3

3.46e-05183454ad7421623e4c0c5ba02eec56e9bdae43ebb88d90
ToppCell3'-Distal_airway-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

WT1 C1QTNF3 LUM OTOGL

3.46e-051834542beb5414958d38a5341870d55229f3b1707e76bf
ToppCellP07-Mesenchymal-mesenchymal_fibroblast-mesenchymal_alveolar_niche_cell|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

C1QTNF3 LUM GDF10 FZD2

3.54e-0518445401257e5c12e38b849fd3d9496c43ded666249ba5
ToppCelldroplet-Lung-21m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l1|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

WT1 LUM GDF10 FZD2

3.69e-051864547c1807fca590cdccf7f5734460bac228d33964ca
ToppCellP03-Mesenchymal-mesenchymal_fibroblast-mesenchymal_alveolar_niche_cell|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

C1QTNF3 LUM GDF10 FZD2

3.69e-05186454c0a036096c2cb23305605b8aaf18869d6e0fb512
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts-Alveolar_fibroblasts_L.2.1.1.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

THBS1 LUM PLPPR4 GDF10

3.69e-051864545473283fb95cee556b1f6934cf72169b676b5bcc
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_myocytic-mes_immature_ASM2_(12)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

FZD7 FLNA PLPPR4 ATRNL1

3.93e-051894540abc7a4900cc9033bc1be69b770ccc54a6bf41b4
ToppCellPCW_13-14|World / Celltypes from embryonic and fetal-stage human lung

PLSCR4 LUM PLPPR4 GDF10

4.01e-0519045462a3ec1ae0829602b0569cc051210551644f1d46
ToppCell3'-Distal_airway-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.0.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

WT1 THBS1 C1QTNF3 LUM

4.09e-05191454f5ce33af56178333730be308253943c54a0724cf
ToppCelldroplet-Lung-30m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l1|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

C1QTNF3 LUM GDF10 FZD2

4.09e-0519145424dc77ee8de01b42559f92721655f4281b114e17
ToppCellPND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

C1QTNF3 LUM GDF10 FZD2

4.09e-051914549f478f36a0b895e607e3bb77fa0f9f03cc0f33fc
ToppCellfacs-MAT|facs / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THBS1 C1QTNF3 LUM GDF10

4.09e-05191454b4fba92f9bd1354a07fedfca7304a3757e6d5beb
ToppCell3'-Distal_airway-Mesenchymal-Fibroblastic-fibroblastic_type_1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

WT1 THBS1 C1QTNF3 LUM

4.18e-05192454a8b7c539dc3037071bf068f372e4215563e11de4
ToppCellfacs-Lung-nan-3m-Mesenchymal-Adventitial_Fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

C1QTNF3 LUM GDF10 FZD2

4.18e-05192454a2c31390da4962bda9a936470b0b68fa1f5d47d1
ToppCellPND28-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

C1QTNF3 LUM GDF10 FZD2

4.18e-05192454cdc652dbfabe41b324fd85c1ed933d29fb73a49f
ToppCellPND28-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_mature|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

C1QTNF3 LUM GDF10 FZD2

4.18e-0519245429bee88b45e23f16543ffc7cc361bc5da5d16a2b
ToppCellfacs-Lung-nan-3m-Mesenchymal-adventitial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

C1QTNF3 LUM GDF10 FZD2

4.18e-05192454eeab1cef7c36ae824381952c5b2c982368c379fd
ToppCell3'-Distal_airway-Mesenchymal-Fibroblastic|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

WT1 THBS1 C1QTNF3 LUM

4.18e-051924542143e1fad2e88b90d668e12af37b2092d379090f
ToppCell3'-Distal_airway-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

WT1 THBS1 C1QTNF3 LUM

4.18e-05192454904c003c4f73b1dfc8243cee02aad2676c515e50
ToppCelldroplet-Lung-30m-Mesenchymal-fibroblast-adventitial_fibroblast|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

C1QTNF3 LUM GDF10 FZD2

4.26e-051934549d0b966d13cbce97beb43de6dc77f006c363a181
ToppCellfacs-Skin-Anagen-3m-Epithelial-bulge_keratinocyte|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FZD7 GDF10 FZD2 FZD3

4.26e-05193454eba3c70701b051bc1ed1f4db9270cb27a77ffc3e
ToppCellwk_20-22-Mesenchymal-Myofibro_&_SMC-Myofibro_2|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

FZD7 FLNA PLPPR4 ATRNL1

4.26e-051934542f203f6f0c2135acb046c9351a633c3b5b254a46
ToppCellPND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

C1QTNF3 LUM GDF10 FZD2

4.26e-05193454051f61156b0e2e95292b2d8377faf3190b50f264
ToppCellTCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma-Stomach_Adenocarcinoma_-_NOS-3|TCGA-Stomach / Sample_Type by Project: Shred V9

THBS1 LUM PLPPR4 FHL5

4.35e-051944542260cd817a6661e5eb6645b0c6786e18fd58371e
ToppCellfacs-Skin-Anagen-3m-Epithelial-outer_bulge|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FZD7 GDF10 FZD2 FZD3

4.35e-051944545d30d3d41d5f19cdf3077cc609aa2738762cb8c5
ToppCelldroplet-Limb_Muscle-nan-21m-Mesenchymal-chondrocyte-like|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TXNRD1 THBS1 LUM GDF10

4.44e-05195454d2c9c58b46bf96f9a536e177b995e340b55c6750
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PLSCR4 FLNA THBS1 ATRNL1

4.44e-05195454dd281a249854800f737dc22e0f375f66dfb5cf5f
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PLSCR4 FLNA THBS1 ATRNL1

4.44e-0519545449c99553629cdd83ee56a2e508d5bc8d34b8507b
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PLSCR4 THBS1 LUM ATRNL1

4.44e-05195454783bfa8110161cbd6def50ce849cae676c39c458
ToppCellASK428-Mesenchymal|ASK428 / Donor, Lineage and Cell class of Lung cells from Dropseq

THBS1 LUM PLPPR4 GDF10

4.44e-051954542b156163975d9a3d3fda1402acd9831d0fdc9e25
ToppCellASK428-Mesenchymal-Fibroblast|ASK428 / Donor, Lineage and Cell class of Lung cells from Dropseq

THBS1 LUM PLPPR4 GDF10

4.44e-05195454c269c0d894a0f55da6495b59d4b9abb9f68df684
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PLSCR4 THBS1 LUM ATRNL1

4.44e-05195454cad6563cc51d212554152c727fc2c249c6a07e4d
ToppCelldroplet-Limb_Muscle-nan-24m-Mesenchymal-chondrocyte-like|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TXNRD1 THBS1 LUM GDF10

4.53e-0519645461bee32ca299219f31a30b57124e44e85b798e9f
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PLSCR4 THBS1 LUM ATRNL1

4.62e-0519745409946ee8dfb15a2a32da06e5b331f3277ee934f4
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts-Alveolar_fibroblasts_L.2.1.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

THBS1 LUM PLPPR4 GDF10

4.62e-0519745494a9603cbd3516fbcce871909693b88f20d41713
ToppCellTracheal-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_pulmonary|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

FLNA OTOP3 OTOGL FHL5

4.62e-05197454ac4f53acb2f8a428b0f2fab3c30a34e095a1bed7
ToppCelldroplet-Bladder-nan-24m-Epithelial-bladder_mesenchymal_cell_(Scara5+)|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

WT1 C1QTNF3 LUM GDF10

4.71e-05198454d4f74320ea6c1a7e568ee5bc48bb66cb45e1004d
ToppCell3'-GW_trimst-2|3' / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PLSCR4 C1QTNF3 LUM RSL24D1

4.71e-05198454cf9861bc14737f2dc72e50222159e0180a6d3e5c
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PLSCR4 THBS1 ATRNL1 FHL5

4.71e-0519845479576525a10ed3e3a9d1608077cd16ecda23376f
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FLNA LUM FHL5 ENTPD3

4.71e-05198454daf367b699726286f0f0f7b4f3a6cf70c462fbeb
ToppCelldistal-mesenchymal-Adventitial_Fibroblast-2|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

WT1 C1QTNF3 LUM ATRNL1

4.71e-05198454bfd720e2dae3b6b3dc2bf8b2096c554fd456e756
ToppCelldistal-2-mesenchymal-Adventitial_Fibroblast|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

WT1 C1QTNF3 LUM GDF10

4.80e-0519945497b475f9110ef7bb29d9cf2109b7e43177830f05
ToppCellBronchial-10x5prime-Stromal-Fibroblastic-Fibro_peribronchial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

LUM PLPPR4 GDF10 GLIS1

4.80e-05199454e1f1950d6f840485e263b83dc81b98910be3ae7a
ToppCell18-Airway-Mesenchymal-Cartilage|Airway / Age, Tissue, Lineage and Cell class

THBS1 C1QTNF3 LUM GDF10

4.80e-05199454f5d0aa4170367c080d3c2f01d9af3529762917fa
ToppCellFibroblasts|World / lung cells shred on cell class, cell subclass, sample id

WT1 LUM PLPPR4 GDF10

4.80e-05199454e2b6752fcabd5249a166486ae6796f2c97c1fcaf
ToppCellwk_15-18-Mesenchymal-Fibroblast-Adventitial_fibro|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

PLSCR4 THBS1 C1QTNF3 LUM

4.80e-051994548de6d7b2067b22cb9b5f01aa56a3803aebc4406d
ToppCell11.5-Airway-Mesenchymal-Airway_Smooth_Muscle|Airway / Age, Tissue, Lineage and Cell class

FZD7 FLNA PLPPR4 ATRNL1

4.80e-051994541a8c77d241bd817a195e1532fd25f51358cb1ff1
ToppCellTracheal-10x3prime_v2-Stromal-Fibroblastic-Fibro_peribronchial|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

LUM PLPPR4 GDF10 ATRNL1

4.80e-05199454e9009eee7f77b9c9917f8e0e723001d9e76eb553
ToppCellBiopsy_IPF-Mesenchymal-PLIN2+_Fibroblasts|Biopsy_IPF / Sample group, Lineage and Cell type

WT1 THBS1 C1QTNF3 LUM

4.89e-052004542c5626ea8fb4b702d4560117e53edf6cfcf1971e
ToppCellproximal-3-mesenchymal-Adventitial_Fibroblast|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

THBS1 C1QTNF3 LUM GDF10

4.89e-05200454869d45b71efd395d050873db5fee2ed0443d5e6f
ToppCellBronchus_Control_(B.)-Stromal-TX-Fibroblasts-1|Bronchus_Control_(B.) / Sample group, Lineage and Cell type

LUM PLPPR4 GLIS1 ATRNL1

4.89e-0520045416a3685c41194a0a4a772e4eee372160263480e0
ToppCellControl_saline-Mesenchymal_myocytic-Myofibroblastic|Control_saline / Treatment groups by lineage, cell group, cell type

FLNA THBS1 GDF10 ATRNL1

4.89e-052004549d5b3c2dcfa55d50acc2ce2c319d51aa525d4cd1
ToppCellTracheal-10x5prime-Stromal-Myofibroblastic-Muscle_perivascular_immune_recruiting|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

FLNA THBS1 PLPPR4 FHL5

4.89e-05200454fc2fc3bfcf1ad9bfb9fe07bbed8068126930bee6
ToppCellproximal-mesenchymal-Adventitial_Fibroblast|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

THBS1 C1QTNF3 LUM GDF10

4.89e-0520045458c5870030192b337e7d883044948634fcd17d2c
ToppCellBronchial-NucSeq-Stromal-Fibroblastic-Fibro_peribronchial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

LUM PLPPR4 GLIS1 ATRNL1

4.89e-05200454fb53be20392a8309a7393774c774a1b1aec6e676
ToppCelltumor_Lymph_Node_/_Brain-Fibroblasts|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass

PLSCR4 LUM PLPPR4 GDF10

4.89e-052004544f7e26b27bd51c32420ed8c2f52d070aee542159
ToppCellproximal-mesenchymal-Adventitial_Fibroblast-3|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

THBS1 C1QTNF3 LUM GDF10

4.89e-0520045405486d86868f6a93429226063cca270f00dd8714
ToppCellEntopeduncular-Endothelial-MURAL-M1(Rgs5Acta2)-M1_3-MURAL_Mural.Rgs5Acta2.Pdgfa_(Mural.Rgs5Acta2.Pdgfa)|Entopeduncular / BrainAtlas - Mouse McCarroll V32

THBS1 NANP FHL5

2.08e-04114453fceb7cc590a47380145fc0d854c9f2350dbb0a59
ToppCellEntopeduncular-Endothelial-MURAL-M1(Rgs5Acta2)-M1_3-MURAL_Mural.Rgs5Acta2.Pdgfa_(Mural.Rgs5Acta2.Pdgfa)-|Entopeduncular / BrainAtlas - Mouse McCarroll V32

THBS1 NANP FHL5

2.08e-041144532cc5d2da5573650c5232a01e2d2128082c4bffcb
ToppCellfrontal_cortex-Non-neuronal-leptomeningeal_cell-VLMC-VLMC_Spp1_Hs3st6|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

FZD7 LUM FZD2

2.60e-0412345364a2d7e40d9c948a9ccaf61c465fb2207e0b7ab8
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_26.46.91|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

THBS1 LUM ATRNL1

2.99e-041294536abdba987c8528f7cb90b32dc01796e02c7352c9
ToppCelldroplet-Fat-Gat-18m-Mesenchymal-nan|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PHF2 C1QTNF3 SVOPL

3.20e-041324534152529611eeacf0c547e2a134d5b98c45426b13
ToppCellBronchial-NucSeq-Stromal-Pericyte-Muscle_pericyte_systemic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

FZD7 PLPPR4 FHL5

3.34e-04134453bffd6ce8998368d4f486b64c220eab3a44ba147b
ToppCellRA-06._Ventricular_Cardiomyocyte_II|World / Chamber and Cluster_Paper

OTOP3 FZD2 OTOGL

3.42e-041354536121b1d30d05b7d476661b932f51191da09dfeeb
ToppCellControl-Classical_Monocyte-cMono_3|Control / Disease condition and Cell class

GDF10 OTOGL SMAD7

4.05e-041434539d1cee36e32aefb6af5c65b3281b31a45d5cd17e
ToppCellfacs-Large_Intestine-Proximal-3m-Epithelial-Goblet_cell,_top_of_crypt_(Distal)|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

C1QTNF3 KRTAP16-1 OTOGL

4.47e-04148453dfd3f2c4b884ea9e23831a242a89ac985b409640
ToppCellCOVID-19-lung-Mesothelial|lung / Disease (COVID-19 only), tissue and cell type

WT1 MST1 ATRNL1

5.21e-04156453e1f563869b3bf997eaa2e756e31b53db1a478903
ToppCellfacs-Lung-Endomucin-24m-Lymphocytic-Natural_Killer_T_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FZD3 NEURL4 ENTPD3

5.51e-041594537619d0d49738dd08daf01b42664691a5323aa793
ToppCellfacs-Lung-Endomucin-24m-Lymphocytic-mature_NK_T_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FZD3 NEURL4 ENTPD3

5.51e-041594534000ed0d3b7d488722bcd0042fa2ff4405aaab82
ToppCellRV-13._Vascular_Smooth_Muscle|World / Chamber and Cluster_Paper

FLNA PLEKHG3 FHL5

5.61e-0416045329c9b4770d0e73d59cffc7937b179484c76b6dcc
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-Mono-Mono_hypoxia-B|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

RLF FLNA THBS1

5.61e-041604536ed37d1fd0304932319d6b942502404115ff36a7
ToppCellmild-Myeloid-CD14_Monocytes_3|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

THBS1 ADAT3 FHL5

5.61e-04160453a83568cd8a0b05642bacd43a8ec443e5ce314c4d
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PLSCR4 ATRNL1 FHL5

5.82e-0416245368c40d12689cc1b6c797e6e48173f0110f8144e4
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PLSCR4 ATRNL1 FHL5

5.82e-04162453735fa3f77b31a4189e431d05c326403c18cbbffb
ToppCellTCGA-Head_and_Esophagus-Primary_Tumor-Head_and_Neck_Carcinoma-Squamous_Cell_Carcinoma-7|TCGA-Head_and_Esophagus / Sample_Type by Project: Shred V9

TXNRD1 FZD7 ENTPD3

6.03e-0416445381c41e1b5535b7969bcf6fa2456f828e8e8e2ff7
ToppCellCOVID-19-lung-Mesothelial|COVID-19 / Disease (COVID-19 only), tissue and cell type

WT1 MST1 ATRNL1

6.03e-0416445383303e2ba52008391b8dc3fae8225ab5bcb20063
ToppCellPND07-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_prolif|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PLEKHG3 SVOPL GLIS1

6.14e-0416545350a8513d8d2630861499393a7f102b35366bad37
ToppCell-SSc-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

WT1 C1QTNF3 LUM

6.25e-04166453bc9323de1373fdc0357e6bb46874f6c4787443a9
ToppCell367C-Lymphocytic-NK_cells-NK_cell_E|NK_cells / Donor, Lineage, Cell class and subclass (all cells)

TSC2 SVOPL FBXO30

6.36e-04167453b5d15773be32cd277125fd3b4056a8fefaefa5ec
ToppCellPND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_prolif|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FLNA PLEKHG3 FHL5

6.36e-04167453784776d1fcc098f84d3c2eca58fa56cb9428f434
ToppCellfacs-Tongue-nan-3m-Epithelial-basal|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TXNRD1 LUM GDF10

6.47e-04168453ca0c4a819f9047fc40d224f7656fec60f6fa05d8
Diseasetuberous sclerosis (is_marker_for)

FLNA TSC2

1.30e-054442DOID:13515 (is_marker_for)
DiseaseEpilepsy, Cryptogenic

TXNRD1 FLNA TSC2

2.52e-0482443C0086237
DiseaseAwakening Epilepsy

TXNRD1 FLNA TSC2

2.52e-0482443C0751111
DiseaseAura

TXNRD1 FLNA TSC2

2.52e-0482443C0236018
Diseasepancreatic cancer (is_marker_for)

THBS1 LUM SMAD7

4.66e-04101443DOID:1793 (is_marker_for)
DiseaseEpilepsy

TXNRD1 FLNA TSC2

5.82e-04109443C0014544
Diseaseinflammatory bowel disease (implicated_via_orthology)

MST1 MST1L

6.38e-0425442DOID:0050589 (implicated_via_orthology)
Diseasecolon carcinoma

ODF1 SMAD7

6.90e-0426442EFO_1001950
Diseaseleiomyoma (is_marker_for)

TSC2 FZD2

8.01e-0428442DOID:127 (is_marker_for)
DiseaseMalignant neoplasm of breast

WT1 MST1 FLNA THBS1 ADAT3 GDF10 OTOGL

9.79e-041074447C0006142
DiseaseMammary Neoplasms, Human

WT1 MST1 FLNA THBS1 GDF10

1.07e-03525445C1257931
DiseaseMammary Carcinoma, Human

WT1 MST1 FLNA THBS1 GDF10

1.07e-03525445C4704874
DiseaseMammary Neoplasms

WT1 MST1 FLNA THBS1 GDF10

1.09e-03527445C1458155
Diseasenephroblastoma (is_marker_for)

WT1 FZD7

1.18e-0334442DOID:2154 (is_marker_for)
DiseaseBreast Carcinoma

WT1 MST1 FLNA THBS1 GDF10

1.19e-03538445C0678222
Diseaseendometrial cancer (is_marker_for)

WT1 SMAD7

1.25e-0335442DOID:1380 (is_marker_for)

Protein segments in the cluster

PeptideGeneStartEntry
GYDLYVTREPCAMCA

ADAT3

281

Q96EY9
DPSCLMPTCPDYWTY

CA5B

216

Q9Y2D0
PSDSYCADPRAFYCD

AJM1

241

C9J069
LLSYVMSGYRCFVCP

CDS2

276

O95674
TNPCYPRDYSISFTM

ENTPD3

286

O75355
LMLYPFSTEYCLICC

OTOP3

291

Q7RTS5
WCYTMDPRTPFDYCA

MST1L

446

Q2TV78
DAYYCAGACEFPMPK

GDF10

401

P55107
ACFLIDFMYFERSPP

PLSCR4

311

Q9NRQ2
PELRFFLCSMYAPVC

FZD2

86

Q14332
REEKPAPSIFYYCCN

NANP

161

Q8TBE9
FSTRCLCDLYMHPYC

ODF1

31

Q14990
YSYMNICKEFSLPPC

ODF1

166

Q14990
FVPCVYIYCRPFMTL

OR4D6

251

Q8NGJ1
FLPFCLCQDEYMESP

C1QTNF3

16

Q9BXJ4
YCFRPSYQCPSMFCD

PIKFYVE

1261

Q9Y2I7
PELRFFLCSMYAPVC

FZD7

96

O75084
FMSRDDYPFCVDCYN

FHL5

201

Q5TD97
CQECPEGYRVTYTPM

FLNA

2476

P21333
CPPKTAASDDRCYRY

ATRNL1

656

Q5VV63
LEMCCDFPDIYFLPT

DNAH14

3421

Q0VDD8
CNCPESYPSAMYCDE

LUM

41

P51884
VCSLPTEYCEYMPDV

DENR

36

O43583
DFRPFLCALYAPICM

FZD3

76

Q9NPG1
MTSISYRPACYRPCY

KRTAP16-1

416

A8MUX0
IQSCFPYGDCYRMAE

GLIS1

521

Q8NBF1
CYTMDPRTPFDYCAL

MST1

431

P26927
MEQRCPLAYYGCTYS

FBXO30

551

Q8TB52
YFMPPPKRSLCYCES

NEURL4

1356

Q96JN8
VCRRGMFNCTYYPCP

OTOGL

931

Q3ZCN5
MFNCTYYPCPAVCTI

OTOGL

936

Q3ZCN5
MATVPVYCVCRLPYD

PHF2

1

O75151
EMDSYYPNRYRCSPE

PLEKHG3

411

A1L390
RTAICPDYCPNMYEE

SETX

371

Q7Z333
SYFYCDCIPLMSILC

OR8K1

181

Q8NGG5
QSPCYCHMFAPSDYR

SVOPL

331

Q8N434
TFMEKLYPYFCPCLN

TRIM69

471

Q86WT6
YCISSDDLFSLPYCP

TXNRD1

326

Q16881
FSCYDRSLSMPYIEP

PLPPR4

101

Q7Z2D5
YSRYPMDFLKPTADC

SMAD7

211

O15105
LGHYSDPMYRCECKP

THBS1

666

P07996
PYMCVSIDCYARFGS

RLF

741

Q13129
MRIEKCYFCSGPIYP

RSL24D1

1

Q9UHA3
RPFMCAYPGCNKRYF

WT1

321

P19544
CYSCPVCSRVFEYMS

ZNF581

86

Q9P0T4
ALYLCPSTCSDYMLG

USP48

116

Q86UV5
EKPYSCPDCSLRFAY

ZNF785

281

A8K8V0
GVVRFSPYCVCDYME

TSC2

636

P49815
SPYCVCDYMEPERGS

TSC2

641

P49815