Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionextracellular matrix constituent conferring elasticity

FBN2 EFEMP2

1.95e-0412352GO:0030023
GeneOntologyMolecularFunctionstructural molecule activity conferring elasticity

FBN2 EFEMP2

2.68e-0414352GO:0097493
GeneOntologyMolecularFunctionextracellular matrix structural constituent

HSPG2 FBN2 SSPOP EFEMP2

3.17e-04188354GO:0005201
GeneOntologyCellularComponentmicrofibril

FBN2 EFEMP2

2.35e-0413372GO:0001527
DomainEGF_3

HSPG2 FBN2 DLL1 SSPOP EFEMP2 PEAR1

5.29e-06235366PS50026
DomainEGF_1

HSPG2 FBN2 DLL1 SSPOP EFEMP2 PEAR1

8.44e-06255366PS00022
DomainEGF_2

HSPG2 FBN2 DLL1 SSPOP EFEMP2 PEAR1

1.05e-05265366PS01186
DomainLDLR_class-A_CS

HSPG2 SSPOP LDLRAD4

6.19e-0540363IPR023415
DomainEGF

HSPG2 FBN2 DLL1 EFEMP2 PEAR1

8.29e-05235365SM00181
DomainEGF_CA

HSPG2 FBN2 DLL1 EFEMP2

8.68e-05122364SM00179
DomainLdl_recept_a

HSPG2 SSPOP LDLRAD4

8.83e-0545363PF00057
DomainEGF-like_Ca-bd_dom

HSPG2 FBN2 DLL1 EFEMP2

9.25e-05124364IPR001881
Domain-

HSPG2 SSPOP LDLRAD4

9.43e-05463634.10.400.10
DomainLDLRA_1

HSPG2 SSPOP LDLRAD4

1.07e-0448363PS01209
DomainEGF-like_dom

HSPG2 FBN2 DLL1 EFEMP2 PEAR1

1.09e-04249365IPR000742
DomainLDrepeatLR_classA_rpt

HSPG2 SSPOP LDLRAD4

1.14e-0449363IPR002172
DomainLDLa

HSPG2 SSPOP LDLRAD4

1.14e-0449363SM00192
DomainLDLRA_2

HSPG2 SSPOP LDLRAD4

1.14e-0449363PS50068
DomainEGF-like_CS

HSPG2 FBN2 DLL1 EFEMP2 PEAR1

1.36e-04261365IPR013032
DomainGrowth_fac_rcpt_

HSPG2 FBN2 DLL1 EFEMP2

2.24e-04156364IPR009030
DomainEMI

SSPOP PEAR1

4.82e-0417362PS51041
DomainEGF_Ca-bd_CS

FBN2 DLL1 EFEMP2

8.56e-0497363IPR018097
DomainEGF_CA

FBN2 DLL1 EFEMP2

9.08e-0499363PS01187
DomainASX_HYDROXYL

FBN2 DLL1 EFEMP2

9.35e-04100363PS00010
DomainEGF-type_Asp/Asn_hydroxyl_site

FBN2 DLL1 EFEMP2

1.11e-03106363IPR000152
DomaincEGF

FBN2 EFEMP2

1.14e-0326362IPR026823
DomaincEGF

FBN2 EFEMP2

1.14e-0326362PF12662
DomainhEGF

FBN2 DLL1

1.32e-0328362PF12661
DomainLaminin_EGF

HSPG2 PEAR1

2.07e-0335362PF00053
DomainEGF_Lam

HSPG2 PEAR1

2.07e-0335362SM00180
Domain-

ZFHX2 NKX2-8 TIGD5 POU5F1B

2.08e-032833641.10.10.60
DomainLaminin_EGF

HSPG2 PEAR1

2.43e-0338362IPR002049
DomainHomeodomain-like

ZFHX2 NKX2-8 TIGD5 POU5F1B

3.69e-03332364IPR009057
DomainHomeobox_CS

ZFHX2 NKX2-8 POU5F1B

5.45e-03186363IPR017970
DomainHomeobox

ZFHX2 NKX2-8 POU5F1B

1.02e-02234363PF00046
DomainHOMEOBOX_1

ZFHX2 NKX2-8 POU5F1B

1.05e-02236363PS00027
DomainHOX

ZFHX2 NKX2-8 POU5F1B

1.06e-02237363SM00389
DomainHomeobox_dom

ZFHX2 NKX2-8 POU5F1B

1.08e-02239363IPR001356
DomainHOMEOBOX_2

ZFHX2 NKX2-8 POU5F1B

1.08e-02239363PS50071
DomainEGF_CA

FBN2 EFEMP2

1.19e-0286362PF07645
Pubmed

Pax6 is required for normal cell-cycle exit and the differentiation kinetics of retinal progenitor cells.

DLL1 FOXN4 GLI1

4.41e-063037324073291
Pubmed

Association analysis of genes involved in the maintenance of the integrity of the extracellular matrix with intracranial aneurysms in a Japanese cohort.

HSPG2 FBN2

6.60e-06437219506372
Pubmed

Fibrillin-1 interactions with fibulins depend on the first hybrid domain and provide an adaptor function to tropoelastin.

FBN2 EFEMP2

1.10e-05537217255108
Pubmed

Development, composition, and structural arrangements of the ciliary zonule of the mouse.

HSPG2 FBN2

1.10e-05537223493297
Pubmed

GAS1 is required for NOTCH-dependent facilitation of SHH signaling in the ventral forebrain neuroepithelium.

DLL1 GLI1

1.65e-05637234698766
Pubmed

Myh10 deficiency leads to defective extracellular matrix remodeling and pulmonary disease.

FBN2 GLI1 EFEMP2

2.36e-055237330389913
Pubmed

Laminin γ1 C-terminal Glu to Gln mutation induces early postimplantation lethality.

HSPG2 POU5F1B

3.95e-05937230456378
Pubmed

Extracellular matrix protein composition dynamically changes during murine forelimb development.

HSPG2 FBN2

6.02e-051137238303699
Pubmed

Basement membrane remodelling regulates mouse embryogenesis.

HSPG2 POU5F1B

6.02e-051137232523119
Pubmed

Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning.

NKX2-8 GLI1

6.02e-051137217442700
Pubmed

SVEP1 is an endogenous ligand for the orphan receptor PEAR1.

HSPG2 PEAR1

6.02e-051137236792666
Pubmed

Genome-wide chromatin accessibility and transcriptome profiling show minimal epigenome changes and coordinated transcriptional dysregulation of hedgehog signaling in Danforth's short tail mice.

NKX2-8 GLI1

8.53e-051337230380057
Pubmed

FOXD1 is required for 3D patterning of the kidney interstitial matrix.

HSPG2 FBN2

8.53e-051337236335435
Pubmed

Ascl1/Mash1 is required for the development of central serotonergic neurons.

NKX2-8 DLL1

9.94e-051437215133515
Pubmed

Comprehensive proteomic characterization of stem cell-derived extracellular matrices.

HSPG2 FBN2 EFEMP2

1.07e-048637328327460
Pubmed

Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus.

ZFHX2 NKX2-8 FBLIM1 FOXN4

1.73e-0426337420932939
Pubmed

A Shh/Gli-driven three-node timer motif controls temporal identity and fate of neural stem cells.

NKX2-8 GLI1

1.86e-041937232938678
Pubmed

HNF3beta and Lim1 interact in the visceral endoderm to regulate primitive streak formation and anterior-posterior polarity in the mouse embryo.

POU5F1B DLL1

2.07e-042037210498685
Pubmed

Ror2 knockout mouse as a model for the developmental pathology of autosomal recessive Robinow syndrome.

DLL1 GLI1

2.28e-042137214745966
Pubmed

Zic2-associated holoprosencephaly is caused by a transient defect in the organizer region during gastrulation.

POU5F1B GLI1

2.28e-042137218617531
Pubmed

Transduction of graded Hedgehog signaling by a combination of Gli2 and Gli3 activator functions in the developing spinal cord.

NKX2-8 GLI1

2.51e-042237215215207
Pubmed

Primary cilia function regulates the length of the embryonic trunk axis and urogenital field in mice.

POU5F1B GLI1

2.51e-042237225224227
Pubmed

Secreted metalloproteases ADAMTS9 and ADAMTS20 have a non-canonical role in ciliary vesicle growth during ciliogenesis.

HSPG2 GLI1

2.75e-042337230814516
Pubmed

ADAMTS9-Mediated Extracellular Matrix Dynamics Regulates Umbilical Cord Vascular Smooth Muscle Differentiation and Rotation.

FBN2 GLI1

2.75e-042337226027930
Pubmed

Forkhead box N4 (Foxn4) activates Dll4-Notch signaling to suppress photoreceptor cell fates of early retinal progenitors.

DLL1 FOXN4

3.80e-042737222323600
Pubmed

Early mouse caudal development relies on crosstalk between retinoic acid, Shh and Fgf signalling pathways.

DLL1 GLI1

3.80e-042737219168680
Pubmed

SMRT-mediated repression of an H3K27 demethylase in progression from neural stem cell to neuron.

DLL1 GLI1

4.39e-042937217928865
Pubmed

Retinaldehyde dehydrogenase 2 (RALDH2)-mediated retinoic acid synthesis regulates early mouse embryonic forebrain development by controlling FGF and sonic hedgehog signaling.

DLL1 GLI1

4.70e-043037216368932
Pubmed

pRb-mediated control of epithelial cell proliferation and Indian hedgehog expression in mouse intestinal development.

DLL1 GLI1

4.70e-043037217257418
Pubmed

Suppressor of fused is required to maintain the multipotency of neural progenitor cells in the retina.

FOXN4 GLI1

4.70e-043037221451052
Pubmed

ADAMTS18 Deficiency Leads to Pulmonary Hypoplasia and Bronchial Microfibril Accumulation.

FBN2 EFEMP2

4.70e-043037232882513
Pubmed

Heritable Thoracic Aortic Disease Overview

FBN2 EFEMP2

4.70e-043037220301299
Pubmed

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

TMC5 DLL1 SEZ6L2 ARSG EFEMP2 HHIPL2

5.58e-0498537612975309
Pubmed

PAR3 restricts the expansion of neural precursor cells by regulating hedgehog signaling.

DLL1 GLI1

5.69e-043337236218069
Pubmed

Efficient isolation of novel mouse genes differentially expressed in early postimplantation embryos.

DLL1 B4GALT3

6.05e-04343727490078
Pubmed

Roles for Dicer1 in the patterning and differentiation of the optic cup neuroepithelium.

FOXN4 GLI1

6.05e-043437221138975
Pubmed

Laminin-511 is an epithelial message promoting dermal papilla development and function during early hair morphogenesis.

HSPG2 GLI1

6.41e-043537218676816
Pubmed

Biosynthesis and processing of human immunodeficiency virus type 1 envelope glycoproteins: effects of monensin on glycosylation and transport.

GAA B4GALT3

7.16e-04373722542563
Pubmed

Role of oligosaccharides in the processing and maturation of envelope glycoproteins of human immunodeficiency virus type 1.

GAA B4GALT3

7.16e-04373722541446
Pubmed

Evidence that mannosyl residues are involved in human immunodeficiency virus type 1 (HIV-1) pathogenesis.

GAA B4GALT3

7.56e-04383722829950
Pubmed

Characterization of the secreted, native gp120 and gp160 of the human immunodeficiency virus type 1.

GAA B4GALT3

7.56e-04383722187500
Pubmed

MTG8 interacts with LHX6 to specify cortical interneuron subtype identity.

DLL1 GLI1

7.96e-043937236064547
Pubmed

Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.

HSPG2 FBN2 SSPOP

8.58e-0417537328071719
Pubmed

A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.

ZFHX2 TIGD5 FBLIM1 FOXN4 GLI1

8.82e-0470937522988430
Pubmed

Six3 and Six6 Are Jointly Required for the Maintenance of Multipotent Retinal Progenitors through Both Positive and Negative Regulation.

FOXN4 GLI1

9.23e-044237230485816
Pubmed

Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.

PRR12 FBN2 IRF2BP1

9.92e-0418437332908313
Pubmed

Single-cell profiling of epigenetic modifiers identifies PRDM14 as an inducer of cell fate in the mammalian embryo.

POU5F1B KDM5A

1.01e-034437224183668
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

HELZ2 PRR12 HSPG2 DLL1 GLI1 ARSG

1.02e-03110537635748872
CoexpressionAtlasFacebaseRNAseq_e10.5_Olfactory Pit_top-relative-expression-ranked_500_k-means-cluster#5

ZFHX2 DLL1 SCG5 PRR13

1.95e-0592374Facebase_RNAseq_e10.5_Olfactory Pit_500_K5
ToppCell343B-Fibroblasts-Fibroblast-E|343B / Donor, Lineage, Cell class and subclass (all cells)

PRR12 SCG5 GLI1 EFEMP2 PEAR1

4.48e-0718637559db239f1864a5d4f1570c93219dbd7ac5b6db35
ToppCell343B-Fibroblasts-Fibroblast-E-|343B / Donor, Lineage, Cell class and subclass (all cells)

PRR12 SCG5 GLI1 EFEMP2 PEAR1

4.48e-071863751bac7825c2fe3e6cdff65026b09b9ccaa40fa27f
ToppCell356C-Myeloid-Macrophage-FABP4+_Macrophage|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

HSPG2 C1orf216 TMC5 SEZ6L2

1.07e-0516637489e2b8453180983533faccb4275867861876d7ee
ToppCell5'-GW_trimst-1.5-LargeIntestine-Mesenchymal-mesothelial_cell-Mesothelium_(RGS5+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NKX2-8 CARNS1 SCG5 UPK3B

1.21e-05171374e780e63510ca47036bc36ca40ecff4098596ee9e
ToppCell5'-GW_trimst-1.5-LargeIntestine-Mesenchymal-mesothelial_cell|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NKX2-8 CARNS1 SCG5 UPK3B

1.61e-05184374e0beb016823514eebdbfc13beb0807efb4470f08
ToppCell343B-Fibroblasts-Fibroblast-E|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

PRR12 SCG5 GLI1 PEAR1

1.64e-0518537402cbf492bc40abebaa93a3a208888afae72fbe06
ToppCell343B-Fibroblasts-Fibroblast-E-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

PRR12 SCG5 GLI1 PEAR1

1.64e-051853741b8e3ddb91797f84e4b15d2457b0c008e5be50db
ToppCell356C-Endothelial_cells-Endothelial-E-|356C / Donor, Lineage, Cell class and subclass (all cells)

HSPG2 FBLIM1 HHIPL2 PEAR1

1.68e-051863742e024097ee361eeb1d855a4edb8ac8cdad35da06
ToppCell356C-Endothelial_cells-Endothelial-E|356C / Donor, Lineage, Cell class and subclass (all cells)

HSPG2 FBLIM1 HHIPL2 PEAR1

1.68e-05186374c3449e54454009973818fc1101933c6f0168258c
ToppCelltumor_Lymph_Node_/_Brain-Fibroblasts-Undetermined|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass

DLL1 SCG5 GLI1 ARSG

1.75e-051883748231e635706a296db6b6da1029a33bbc1b52478e
ToppCellNeuronal_cells-Schwann_cells|World / Lineage and Cell class

NKX2-8 SEZ6L2 SCG5 ARSG

1.79e-05189374371cdc92549269e45c23c5a5b3cae9c5d35ee217
ToppCellNeuronal_cells|World / Lineage and Cell class

NKX2-8 SEZ6L2 SCG5 ARSG

1.79e-051893743948775a0ebd4b32c1623d5487f5581e6e2934d7
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibro-meso-mesothelial_cell-Mesothelium-Mesothelium_L.2.6.0.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SEZ6L2 SCG5 EFEMP2 UPK3B

1.82e-05190374f39ce1678fc375eb2a3af781ddb772b0f12c5744
ToppCell3'-GW_trimst-1-LargeIntestine-Mesenchymal-mesothelial_cell|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NKX2-8 CARNS1 SCG5 UPK3B

1.90e-051923742f539653a20006bef814e6b4acd1023d6fdad5c6
ToppCellParenchyma_COVID-19-Stromal-TX-Mesothelial-1|Parenchyma_COVID-19 / Sample group, Lineage and Cell type

CARNS1 SEZ6L2 SCG5 UPK3B

2.23e-05200374bf50e30d5cafb71c567e89580f62084d2f894170
ToppCellLung_Parenchyma-Severe-Mesenchymal-Mesenchymal-Mesothelial-1-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CARNS1 SEZ6L2 SCG5 UPK3B

2.23e-052003745e5ad07679d5dd2ca80249bce9aaf4a95d42187b
ToppCellLung_Parenchyma-Severe-Mesenchymal-Mesenchymal-Mesothelial-1|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

CARNS1 SEZ6L2 SCG5 UPK3B

2.23e-05200374c800f20adedf4ca736c740510889e92d8bf0ba44
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Macroglial|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NKX2-8 RPP25L SEZ6L2

6.52e-059437300b932421d77f0fd8d6ffe439c992ebc95ad7c94
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Macroglial-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NKX2-8 RPP25L SEZ6L2

6.73e-0595373a09443e527d37adb637a66ca857525dab1c39a9b
ToppCellTCGA-Liver-Primary_Tumor-Hepatocellular_Carcinoma-Hepatocholangiocarcinoma_(Mixed)-1|TCGA-Liver / Sample_Type by Project: Shred V9

NKX2-8 POU5F1B FBN2

9.85e-0510837390c95fe363ced0d87f77e44165ed3cc319a6dfdf
ToppCellGlobus_pallidus-Macroglia-OLIGODENDROCYTE-O2|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

NKX2-8 SSPOP ARSG

1.41e-04122373d4152c45dfbb979ddf8380b4896db753a79cad9e
ToppCellGlobus_pallidus-Macroglia-OLIGODENDROCYTE-O2-Trf|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

NKX2-8 SSPOP ARSG

1.41e-0412237340f983623c990203df4ba997e296231489d51012
ToppCellPosterior_cortex-Macroglia-OLIGODENDROCYTE|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

NKX2-8 SSPOP ARSG

1.48e-041243739f169fa17be1842a6bd83778ff30465a740edd5f
ToppCellGlobus_pallidus-Macroglia-OLIGODENDROCYTE|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

NKX2-8 SSPOP ARSG

1.67e-0412937398a5f24de72d2ae6a57787226b2e523ddd13b2c5
ToppCellAT2_cells-IPF_02|World / lung cells shred on cell class, cell subclass, sample id

HSPG2 SCG5 EFEMP2

1.74e-04131373ff4e618bd944f852bbd34438f740187aca82460f
ToppCellHippocampus-Macroglia-OLIGODENDROCYTE-O2-Trf|Hippocampus / BrainAtlas - Mouse McCarroll V32

NKX2-8 SSPOP ARSG

1.78e-04132373dc6edfa821a1cdc645668b0af5ba5ff80dee10bd
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Macroglial-oligodendrocyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NKX2-8 RPP25L SEZ6L2

1.78e-041323733661665ed5b257f51530122cb9a9c849b5baa1fb
ToppCellHippocampus-Macroglia-OLIGODENDROCYTE-O2|Hippocampus / BrainAtlas - Mouse McCarroll V32

NKX2-8 SSPOP ARSG

1.78e-0413237360ced08bda5efc95a6f116cd0c6d1a779d99ed38
ToppCellprimary_visual_cortex-Non-neuronal-oligodendrocyte-Oligo-Oligo_Synpr|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

NKX2-8 SSPOP ARSG

1.86e-041343733dd4b5eddc94c1d49ab23b287ee234db3a55331b
ToppCellHippocampus-Macroglia-OLIGODENDROCYTE|Hippocampus / BrainAtlas - Mouse McCarroll V32

NKX2-8 SSPOP ARSG

1.99e-041373735e97480f014f1d9267e8126f1d0e58acd22f36aa
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-mature_alpha-beta_T_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TBC1D12 HSPG2 CD6

2.03e-04138373321070b6900887b27da0f2b25808a05a8ab89ee7
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-BM_CD8_+_CD4_T_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TBC1D12 HSPG2 CD6

2.03e-0413837319ffd66256fa94d728138d37d0a5a3bac7722dbb
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMC5 SSPOP SCG5

2.12e-041403737ca49bd7ba9381e75c10f888775df17e5d46804d
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMC5 SSPOP SCG5

2.12e-041403731a31bc33d5723b9bc528cc0047ca5f4c80531c7a
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

C1orf216 FBLIM1 SEC31B

2.55e-041493737e295b2b82dea0754e98f8cef788e2781e5d641f
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

C1orf216 FBLIM1 SEC31B

2.55e-04149373b4f77dc5f9d08b249fe5cd9a0acf86308c528ef4
ToppCellPND01-Immune-Immune_Myeloid-DC|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ARRDC4 FLAD1 PRR13

2.70e-04152373c8faa83dcaddb2ce2bb890f90dd8e676f7dcb1b3
ToppCellPND01-Immune-Immune_Myeloid-DC-cDC2-cDC2_mature|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ARRDC4 FLAD1 PRR13

2.70e-04152373c3f00beb8b6fde99263d5ed6bbe3c2415d02f91d
ToppCellPND01-Immune-Immune_Myeloid-DC-cDC2|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ARRDC4 FLAD1 PRR13

2.70e-04152373cefc0ab592e99badf145fb95adf9906cb81be81c
ToppCellLPS-IL1RA-Myeloid_granulocytic-Neutrophils|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MAP3K9 ZFHX2 ARRDC4

2.81e-0415437343735f7c58cac51855ded486ee8d8729a1b9909e
ToppCellLPS-IL1RA-Myeloid_granulocytic|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MAP3K9 ZFHX2 ARRDC4

2.81e-04154373d55fb73461885e1e02061a344ff89624ef4de487
ToppCellControl-Epithelial_alveolar-AT_2-Differentiating_AT1|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PRR12 ZFHX2 ARRDC4

2.97e-041573734766f7d545bf2d775390589460677519cb92f4d5
ToppCellICU-SEP-Lymphocyte-T_NK-NK_CD56bright|ICU-SEP / Disease, Lineage and Cell Type

DLL1 SCG5 FLAD1

3.02e-0415837353a942cdab4a3c6813dbe11368135a24b8de1880
ToppCell356C-Myeloid-Macrophage-FABP4+_Macrophage|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

HSPG2 TMC5 SEZ6L2

3.25e-041623732259e9536147e9cdee772e3a30ba7d104573262c
ToppCell368C-Fibroblasts-Fibroblast-J_(Lipofibroblast)-|368C / Donor, Lineage, Cell class and subclass (all cells)

CARNS1 SEZ6L2 UPK3B

3.49e-041663734d63c758d46e73311b864148c646bf081498dee7
ToppCell368C-Fibroblasts-Fibroblast-J_(Lipofibroblast)|368C / Donor, Lineage, Cell class and subclass (all cells)

CARNS1 SEZ6L2 UPK3B

3.49e-041663734160ccf9291072a6e2782f9ad141bc9a9747f3ad
ToppCellnormal_Lung-Fibroblasts-Mesothelial_cells|Fibroblasts / Location, Cell class and cell subclass

CARNS1 SCG5 UPK3B

3.56e-04167373892a2dc83ab5de5a1016402f8e95d2aabf651326
ToppCell368C-Fibroblasts-Fibroblast-J_(Lipofibroblast)|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

CARNS1 SEZ6L2 UPK3B

3.62e-04168373e870d2e69316406f45112ed0bf324b24f902a99e
ToppCell368C-Fibroblasts-Fibroblast-J_(Lipofibroblast)-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

CARNS1 SEZ6L2 UPK3B

3.62e-04168373403aba73a0f9ffb32252288d075fad8a588ca440
ToppCelldroplet-Lung-nan-18m-Lymphocytic-Regulatory_T|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBN2 CD6 LDLRAD4

3.75e-04170373064786c1f1ad7665358964765910b0ad46d14685
ToppCelldroplet-Lung-nan-18m-Lymphocytic-regulatory_T_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBN2 CD6 LDLRAD4

3.75e-041703736725747df336697708b94999b3ebb40f1721da16
ToppCelldroplet-Lung-18m-Hematologic-lymphocytic-regulatory_T_cell-regulatory_T_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FBN2 CD6 LDLRAD4

3.81e-041713737c0a1b0676f6749ee710c6bdeca6d6f7fac79b69
ToppCelldroplet-Lung-18m-Hematologic-lymphocytic-regulatory_T_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FBN2 CD6 LDLRAD4

3.81e-0417137310492832db8ebc3cf85503c441f33bd94df9458e
ToppCelldroplet-Spleen-nan-24m-Lymphocytic-T_cell|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD6 SCG5 LDLRAD4

4.01e-04174373919fc124affc69acfd8f575f2c372674f3d2625e
ToppCellASK428-Immune-B_cell|Immune / Donor, Lineage and Cell class of Lung cells from Dropseq

TMC5 ARSG UPK3B

4.08e-04175373e0979e5795a49b4e5c9b88e7fe6b7bda7a413a6c
ToppCellmetastatic_Brain-Endothelial_cells-Stalk-like_ECs|Endothelial_cells / Location, Cell class and cell subclass

MAP3K9 ZFHX2 C1orf216

4.08e-04175373f6a6db992e803d36c866a91706b02f67e0fd3e09
ToppCellAT1_cells-SSc-ILD_02|World / lung cells shred on cell class, cell subclass, sample id

HSPG2 KDM5A UPK3B

4.15e-041763734a30bb771297b30926fb98e2b5ec0dbdc46feac7
ToppCellAT1_cells-HP_01|World / lung cells shred on cell class, cell subclass, sample id

HSPG2 KDM5A UPK3B

4.15e-04176373458720776b0151cd55acc352d509599cb62f0ca8
ToppCelldroplet-Limb_Muscle-nan-24m-Endothelial-unknown|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TIGD5 SSPOP FLAD1

4.29e-04178373f2002a5c4758d0af6c1880ca12f0af0d5e8888e4
ToppCell(5)_Glands_mucous|World / Oesophagus cell shreds on cell class (v1) and cell subclass (v1)

TMC5 SEZ6L2 KDM5A

4.29e-04178373f0f19b0d78f2cc5df4d4c321a953a6e447d5114a
ToppCellASK454-Endothelial-Lymphatic|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq

C1orf216 FBLIM1 PEAR1

4.36e-04179373fd84a79f76a01c0377dff5b20016b004d369f96f
ToppCell3'-Parenchyma_lung-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell-EC_arterial-EC_arterial_L.2.4.1.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

HSPG2 EFEMP2 PEAR1

4.36e-04179373d2db9e70b780643f1e004c41a70464d0abe26088
ToppCellfacs-Heart-LV-3m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMC5 SSPOP PEAR1

4.50e-041813731db1eb7d330a7e5090994007ae287e11f0a74450
ToppCellfacs-Heart-LV-3m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMC5 SSPOP PEAR1

4.50e-0418137306174ce9240c9261c0f51a1b0d875335d60722e5
ToppCell5'-GW_trimst-2-LargeIntestine-Mesenchymal-mesothelial_cell|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NKX2-8 CARNS1 UPK3B

4.65e-04183373c5caac6ed6c8d67f5c336281d9fd903976509445
ToppCell5'-GW_trimst-1.5-LargeIntestine-Mesenchymal-mesothelial_cell-Mesothelium|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NKX2-8 CARNS1 UPK3B

4.65e-0418337303649492c37f9b274a1caf3e2132ce2915cf1df5
ToppCell5'-GW_trimst-2-LargeIntestine-Mesenchymal-mesothelial_cell-Mesothelium|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NKX2-8 CARNS1 UPK3B

4.65e-041833739d5a363fbe6f0a1668c9d584df65ee1c283349c7
ToppCellfacs-Liver-Non-hepatocytes-24m-Endothelial-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NKX2-8 SCG5 UPK3B

4.65e-04183373ebe369dc80c4fbf8f4dbe947147f8c47507ffb60
ToppCellwk_20-22-Mesenchymal-Mesothelial|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

CARNS1 SCG5 UPK3B

4.72e-04184373804f8a41cd6b1361448872bf352bf0a38a0fac66
ToppCelldroplet-Spleen-nan-18m-Lymphocytic-T_cell|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBN2 CD6 SCG5

4.72e-041843738c23945bafe8926f25836bc208115edd5214a2b0
ToppCellwk_20-22-Mesenchymal-Mesothelial-Late_mesothelial|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

CARNS1 SCG5 UPK3B

4.72e-0418437360dd055c2e2e92b838ac649c12e8cccd9c3b1b71
ToppCell3'-GW_trimst-1-LargeIntestine-Mesenchymal-mesothelial_cell-Mesothelium_(RGS5+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CARNS1 SCG5 UPK3B

4.79e-0418537311fbea1eb1d9a3e4480d0d2b0f7b02e2866b8142
ToppCelldroplet-Kidney-KIDNEY-1m-Mesenchymal-Stroma____fibroblast|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBN2 GLI1 EFEMP2

4.79e-04185373785c55d39909fac74415f24427979691e7e694e6
ToppCelldroplet-Kidney-KIDNEY-1m-Mesenchymal|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBN2 GLI1 EFEMP2

4.79e-0418537397a1dcacbc48dc3f41c26fbb59af35c935f894d4
ToppCellThalamus-Endothelial|Thalamus / BrainAtlas - Mouse McCarroll V32

HELZ2 HSPG2 PEAR1

4.87e-04186373dcc6e4417c4123d5ca6b96fa8ca4874626aaebdb
ToppCelldroplet-Kidney-KIDNEY-1m-Mesenchymal-fibroblast|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBN2 GLI1 EFEMP2

4.87e-0418637394d577dbb6bfacf50632e1fe8af041b35a1e6b23
ToppCelldroplet-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBN2 GLI1 UPK3B

4.95e-041873734e553721fa5598cb211f44e3226280b7e6885484
ToppCelldroplet-Pancreas-Exocrine-18m-Mesenchymal|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBN2 GLI1 UPK3B

4.95e-04187373d36e7fc6125e7a4310499365022d38f34b757a73
ToppCelldroplet-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBN2 GLI1 UPK3B

4.95e-04187373827eae63fabf6892a82ce7779b5f395958d3d628
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

HSPG2 FBN2 UPK3B

4.95e-041873734ae7465174e0295d2c3b614b321a3b2f514dd22a
ToppCellwk_15-18-Mesenchymal-Mesothelial-Late_mesothelial|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

CARNS1 SCG5 UPK3B

5.02e-0418837338a53f99f1876359983936403aefca93281d10fd
ToppCellTCGA-Breast-Primary_Tumor-Breast_Carcinoma-Infiltrating_Lobular_Carcinoma-6|TCGA-Breast / Sample_Type by Project: Shred V9

DLL1 GLI1 PEAR1

5.02e-04188373c90669b51e1902fe7726555290c91c92a911df83
ToppCell3'-GW_trimst-1-LargeIntestine-Mesenchymal-mesothelial_cell-Mesothelium|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NKX2-8 CARNS1 UPK3B

5.02e-0418837300c5259bcb83218b7d44f4d585d9b68ef49763ab
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

MAP3K9 HSPG2 TMC5

5.02e-0418837343a3a59f92ad93509d4166bd025aed0b1b39a008
ToppCellwk_08-11-Mesenchymal-Mesothelial-Early_mesothelial|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

CARNS1 SCG5 UPK3B

5.02e-041883736151051c027c7ff7d5d4bf5f1e11d7fe58eb22ed
ToppCell10x3'2.3-week_12-13-Mesenchymal_osteo-stroma-osteochondral_precursor|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

SEZ6L2 GLI1 EFEMP2

5.02e-04188373ed92cddf47defea2f904d36c7ae05ffa323349a9
ToppCellfacs-Pancreas-Endocrine-24m|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZFHX2 SEZ6L2 SCG5

5.10e-04189373010fdd70e9d0e21b856306a29ff877776a480319
ToppCellwk_15-18-Mesenchymal-Mesothelial|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

CARNS1 SCG5 UPK3B

5.26e-04191373b5374674312ff5803a1d369f5533027532344679
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_mesothelial_(19)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

CARNS1 SCG5 UPK3B

5.26e-041913734c4eb61e6179d2f8fc524d2f813db9cba84f67a2
ToppCell3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting-Basal_resting_L.0.0.0.3|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NKX2-8 DLL1 EFEMP2

5.26e-041913734180521a8c5e0ad629cacdd22dc6a94e94b28816
ToppCellfacs-Pancreas-Endocrine-24m-Epithelial|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZFHX2 SEZ6L2 SCG5

5.26e-04191373a251b134f67a0a1ef3a42f50042f128a17f20b22
ToppCellfacs-Pancreas-Endocrine-24m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZFHX2 SEZ6L2 SCG5

5.26e-041913733387b95a3f2445c672d407922fdce3a91eabaef8
ToppCelldroplet-Kidney-nan-18m-Mesenchymal-fibroblast|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBLIM1 GLI1 EFEMP2

5.34e-0419237384149a5c6c3b3c9b86aed77cf8e72d99ef099fab
ToppCellfacs-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l1|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

HSPG2 GLI1 EFEMP2

5.34e-041923737b48df661f61ce494bf6f0b9a74b0422e29c24bf
ToppCelldroplet-Pancreas-Endocrine|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SEZ6L2 SCG5 GAA

5.34e-041923730dfd1e9896c34aee0f842f8de5d0e3af62a15f68
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts-Peribronchial_fibroblasts_L.2.1.3.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FBLIM1 GLI1 EFEMP2

5.42e-04193373b05361ffe111a38cfa26eb86e4ae62c15ac99b7b
ToppCelldroplet-Limb_Muscle-nan-18m-Mesenchymal|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HSPG2 GAA EFEMP2

5.42e-0419337349600db68ed65cafc67bd45a285b364e4f5f88af
ToppCellfacs-Pancreas-Endocrine|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZFHX2 SEZ6L2 SCG5

5.42e-0419337315c86e20b97b6983410b36d308cddff56d141c98
ToppCelldroplet-Limb_Muscle-nan-18m-Mesenchymal-mesenchymal_stem_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HSPG2 GAA EFEMP2

5.42e-0419337345b5cab4dfeb0ed3b13631db5963740a792b810f
ToppCelldroplet-Pancreas-Endocrine-21m|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SEZ6L2 SCG5 GAA

5.51e-041943733a3ecedcdc7691cf21775818b598208fcb980c29
Disease1-ribosyl-imidazoleacetate measurement

TIGD5 CARNS1

4.62e-059342EFO_0800034
DiseaseAbnormal behavior

PRR12 DLL1

1.53e-0416342C0233514
Diseasecentral nervous system disease (implicated_via_orthology)

IRF2BP1 SEC31B

1.53e-0416342DOID:331 (implicated_via_orthology)
Diseaseobsolete_red blood cell distribution width

TBC1D12 HELZ2 TIGD5 FBN2 IRF2BP1 SCG5 ARSG

7.40e-041347347EFO_0005192
Diseaserectum cancer

POU5F1B SCG5

1.08e-0342342EFO_1000657
Diseasecancer

POU5F1B FBN2 SCG5 LDLRAD4

1.12e-03400344MONDO_0004992
DiseaseFamilial thoracic aortic aneurysm and aortic dissection

FBN2 EFEMP2

1.71e-0353342C4707243
Diseasesusceptibility to vaginal yeast infection measurement

SCG5 GAA

2.56e-0365342EFO_0008412
Diseasecancer (implicated_via_orthology)

NKX2-8 DLL1 FLAD1

3.60e-03268343DOID:162 (implicated_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
CYCPLPAGQAGAPPP

TBC1D12

86

O60347
GGPPAPQGLPYCPER

B4GALT3

66

O60512
GDPPPGLCQPELQPD

C1orf216

16

Q8TAB5
YPPAQLPCSDGPSPG

CARNS1

211

A5YM72
PGYNHPPCPACPQGD

ARSG

171

Q96EG1
QGYPDPPNPCPVGKT

SCG5

111

P05408
PCNPPAPAGDKGFQP

DMRTC1;

151

Q5HYR2
IPPYPQPPNCEGEVC

ARRDC4

366

Q8NCT1
PPPPCEPNEFPCGNG

HSPG2

321

P98160
PQPPSEEQFGCPGSP

CD6

636

P30203
PPCPPPYELCGGMAY

POU5F1B

61

Q06416
PPNCLQPCTPGYYGP

PEAR1

171

Q5VY43
GPPTNYGPNPCPQQA

GLI1

756

P08151
YGPNPCPQQASYPDP

GLI1

761

P08151
GGPALYPPPEGQVCN

GLI1

1021

P08151
PPAAACPLPGYPAFG

NKX2-8

201

O15522
AGQPGPNPYPPNIGC

PRR13

6

Q9NZ81
PNPYPPNIGCPGGSN

PRR13

11

Q9NZ81
PGGYAAEFVPPPECP

KDM5A

6

P29375
YGGPNCQFLLPELPP

DLL1

511

O00548
DGCPNNELENPPYVP

GAA

531

P10253
FNGGCPPPPPVLDGE

FBLIM1

81

Q8WUP2
ANPDYGFGEPCQPCP

FBN2

731

P35556
PLGQPPGAQLYCPAC

HELZ2

31

Q9BYK8
GHPQCLDYGPPFQPP

HHIPL2

41

Q6UWX4
PNPCPPGYEPDDQDS

EFEMP2

106

O95967
PLFPGYGPQCPVDLA

FLAD1

56

Q8NFF5
CQPGGEDPSCYPPIQ

MAP3K9

121

P80192
PQQYPEPAPAALCGP

IRF2BP1

351

Q8IU81
PPGAQQCPPVGLYGP

FOXN4

151

Q96NZ1
DQPPPQGLGDYCEGP

SSPOP

3281

A2VEC9
FPVPYLPGDPGAPCS

SEC31B

961

Q9NQW1
CLPGYALEPPGPPNA

SEZ6L2

491

Q6UXD5
PLGDIDFCPPNPGPD

PRR12

1136

Q9ULL5
PQEGPDCGHFPPNDP

ZFHX2

76

Q9C0A1
VACDPPQQGDPGYPL

RNASE8

131

Q8TDE3
LDPNECGYQPPGAPP

RPP25L

126

Q8N5L8
PDVPGPLNNPDYPGT

TMC5

36

Q6UXY8
PAPPPPAEGGYGDEQ

TIGD5

221

Q53EQ6
PFCNAPLPGPGPYRE

UPK3B

196

Q9BT76
DGEEPPPYQGPCTLQ

LDLRAD4

176

O15165