Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	olfactory receptor activity	OR2T3 OR2T8 OR2T1 OR2T29 OR2T5 OR10AG1 OR2T12 OR2T10 OR2T6 OR2T34 OR5M1 OR2T33 OR2T27 OR2T4 OR2T11 OR2T35 OR2T7 OR4K1	5.60e-22	431	33	18	GO:0004984
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	OR2T3 MC5R OR2T8 OPN1LW OR2T1 OR2T29 OR2T5 OR10AG1 OR2T12 OSMR OR2T10 OR2T6 OR2T34 OR5M1 OR2T33 OR2T27 OR2T4 EGFR OR2T11 OR2T35 OR2T7 OR4K1 PKD1	5.20e-20	1353	33	23	GO:0004888
GeneOntologyMolecularFunction	G protein-coupled receptor activity	OR2T3 MC5R OR2T8 OPN1LW OR2T1 OR2T29 OR2T5 OR10AG1 OR2T12 OR2T10 OR2T6 OR2T34 OR5M1 OR2T33 OR2T27 OR2T4 OR2T11 OR2T35 OR2T7 OR4K1	2.25e-19	884	33	20	GO:0004930
GeneOntologyMolecularFunction	L-amino acid transmembrane transporter activity	SLC6A9 SERINC5 SLC38A9	2.18e-04	71	33	3	GO:0015179
GeneOntologyMolecularFunction	organic cation transmembrane transporter activity	SLC6A9 SERINC5 SLC38A9	3.45e-04	83	33	3	GO:0015101
GeneOntologyMolecularFunction	amino acid transmembrane transporter activity	SLC6A9 SERINC5 SLC38A9	6.87e-04	105	33	3	GO:0015171
GeneOntologyMolecularFunction	neutral L-amino acid transmembrane transporter activity	SLC6A9 SLC38A9	2.09e-03	41	33	2	GO:0015175
GeneOntologyBiologicalProcess	detection of stimulus	OR2T3 OR2T8 OPN1LW BACE1 OR2T1 OR2T29 OR2T5 OR10AG1 OR2T12 OR2T10 OR2T6 OR2T34 OR5M1 OR2T33 OR2T27 OR2T4 OR2T11 OR2T35 OR2T7 OR4K1 PKD1	4.80e-23	722	33	21	GO:0051606
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception of smell	OR2T3 OR2T8 OR2T1 OR2T29 OR2T5 OR10AG1 OR2T12 OR2T10 OR2T6 OR2T34 OR5M1 OR2T33 OR2T27 OR2T4 OR2T11 OR2T35 OR2T7 OR4K1	3.29e-22	432	33	18	GO:0050911
GeneOntologyBiologicalProcess	sensory perception of smell	OR2T3 OR2T8 OR2T1 OR2T29 OR2T5 OR10AG1 OR2T12 OR2T10 OR2T6 OR2T34 OR5M1 OR2T33 OR2T27 OR2T4 OR2T11 OR2T35 OR2T7 OR4K1	1.24e-21	465	33	18	GO:0007608
GeneOntologyBiologicalProcess	detection of stimulus involved in sensory perception	OR2T3 OR2T8 BACE1 OR2T1 OR2T29 OR2T5 OR10AG1 OR2T12 OR2T10 OR2T6 OR2T34 OR5M1 OR2T33 OR2T27 OR2T4 OR2T11 OR2T35 OR2T7 OR4K1	1.54e-21	582	33	19	GO:0050906
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception	OR2T3 OR2T8 OR2T1 OR2T29 OR2T5 OR10AG1 OR2T12 OR2T10 OR2T6 OR2T34 OR5M1 OR2T33 OR2T27 OR2T4 OR2T11 OR2T35 OR2T7 OR4K1	2.65e-21	485	33	18	GO:0050907
GeneOntologyBiologicalProcess	detection of chemical stimulus	OR2T3 OR2T8 OR2T1 OR2T29 OR2T5 OR10AG1 OR2T12 OR2T10 OR2T6 OR2T34 OR5M1 OR2T33 OR2T27 OR2T4 OR2T11 OR2T35 OR2T7 OR4K1	1.06e-20	524	33	18	GO:0009593
GeneOntologyBiologicalProcess	sensory perception of chemical stimulus	OR2T3 OR2T8 OR2T1 OR2T29 OR2T5 OR10AG1 OR2T12 OR2T10 OR2T6 OR2T34 OR5M1 OR2T33 OR2T27 OR2T4 OR2T11 OR2T35 OR2T7 OR4K1	2.29e-20	547	33	18	GO:0007606
GeneOntologyBiologicalProcess	sensory perception	OR2T3 OR2T8 OPN1LW BACE1 OR2T1 OR2T29 OR2T5 OR10AG1 OR2T12 OR2T10 OR2T6 OR2T34 OR5M1 OR2T33 OR2T27 OR2T4 OR2T11 OR2T35 OR2T7 OR4K1	5.24e-18	1072	33	20	GO:0007600
GeneOntologyBiologicalProcess	G protein-coupled receptor signaling pathway	OR2T3 MC5R OR2T8 OPN1LW OR2T1 OR2T29 OR2T5 OR10AG1 OR2T12 OR2T10 OR2T6 OR2T34 OR5M1 OR2T33 OR2T27 OR2T4 OR2T11 OR2T35 OR2T7 OR4K1	8.62e-16	1395	33	20	GO:0007186
GeneOntologyBiologicalProcess	neutral amino acid transport	SLC6A9 SERINC5 SLC38A9	1.20e-04	60	33	3	GO:0015804
GeneOntologyBiologicalProcess	L-amino acid transport	SLC6A9 SERINC5 SLC38A9	6.79e-04	108	33	3	GO:0015807
Domain	Olfact_rcpt	OR2T3 OR2T8 OR2T1 OR2T29 OR2T5 OR10AG1 OR2T12 OR2T10 OR2T6 OR2T34 OR5M1 OR2T33 OR2T27 OR2T4 OR2T11 OR2T35 OR4K1	9.35e-21	393	32	17	IPR000725
Domain	GPCR_Rhodpsn_7TM	OR2T3 MC5R OR2T8 OPN1LW OR2T1 OR2T29 OR2T5 OR10AG1 OR2T12 OR2T10 OR2T6 OR2T34 OR5M1 OR2T33 OR2T27 OR2T4 OR2T11 OR2T35 OR4K1	6.07e-20	670	32	19	IPR017452
Domain	7tm_1	OR2T3 MC5R OR2T8 OPN1LW OR2T1 OR2T29 OR2T5 OR10AG1 OR2T12 OR2T10 OR2T6 OR2T34 OR5M1 OR2T33 OR2T27 OR2T4 OR2T11 OR2T35 OR4K1	7.38e-20	677	32	19	PF00001
Domain	G_PROTEIN_RECEP_F1_1	OR2T3 MC5R OR2T8 OPN1LW OR2T1 OR2T29 OR2T5 OR10AG1 OR2T12 OR2T10 OR2T6 OR2T34 OR5M1 OR2T33 OR2T27 OR2T4 OR2T11 OR2T35 OR4K1	9.20e-20	685	32	19	PS00237
Domain	G_PROTEIN_RECEP_F1_2	OR2T3 MC5R OR2T8 OPN1LW OR2T1 OR2T29 OR2T5 OR10AG1 OR2T12 OR2T10 OR2T6 OR2T34 OR5M1 OR2T33 OR2T27 OR2T4 OR2T11 OR2T35 OR4K1	1.08e-19	691	32	19	PS50262
Domain	GPCR_Rhodpsn	OR2T3 MC5R OR2T8 OPN1LW OR2T1 OR2T29 OR2T5 OR10AG1 OR2T12 OR2T10 OR2T6 OR2T34 OR5M1 OR2T33 OR2T27 OR2T4 OR2T11 OR2T35 OR4K1	1.11e-19	692	32	19	IPR000276
Domain	7TM_GPCR_Srsx	OR2T3 MC5R OR2T34	9.17e-04	112	32	3	SM01381
Pathway	REACTOME_OLFACTORY_SIGNALING_PATHWAY	OR2T3 OR2T8 OR2T1 OR2T29 OR2T5 OR10AG1 OR2T12 OR2T10 OR2T6 OR2T34 OR5M1 OR2T33 OR2T27 OR2T4 OR2T11 OR2T35 OR2T7 OR4K1	6.75e-20	417	32	18	M4072
Pathway	REACTOME_SENSORY_PERCEPTION	OR2T3 OR2T8 OPN1LW OR2T1 OR2T29 OR2T5 OR10AG1 OR2T12 OR2T10 OR2T6 OR2T34 OR5M1 OR2T33 OR2T27 OR2T4 OR2T11 OR2T35 OR2T7 OR4K1	4.17e-18	636	32	19	M41834
Pathway	KEGG_OLFACTORY_TRANSDUCTION	OR2T3 OR2T8 OR2T1 OR2T29 OR2T5 OR10AG1 OR2T12 OR2T10 OR2T6 OR2T34 OR5M1 OR2T33 OR2T27 OR2T4 OR2T11 OR4K1	3.35e-17	389	32	16	M14091
Pathway	REACTOME_OLFACTORY_SIGNALING_PATHWAY	OR2T1 OR2T29 OR2T5 OR2T4	1.80e-05	70	32	4	MM14984
Pathway	REACTOME_SENSORY_PERCEPTION	OPN1LW OR2T1 OR2T29 OR2T5 OR2T4	6.32e-05	190	32	5	MM15687
Pubmed	The human olfactory receptor gene family.	OR2T1 OR2T5 OR10AG1 OR2T12 OR2T10 OR2T34 OR5M1 OR2T33 OR2T27 OR2T4 OR2T11 OR2T35 OR2T7 OR4K1	2.57e-17	541	33	14	14983052
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR2T8 OR2T1 OR2T29 OR2T5 OR10AG1 OR2T12 OR2T6 OR5M1 OR2T33 OR2T4 OR2T35 OR4K1	1.85e-16	340	33	12	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR2T8 OR2T1 OR2T29 OR2T5 OR10AG1 OR2T12 OR2T6 OR5M1 OR2T33 OR2T4 OR2T35 OR4K1	1.85e-16	340	33	12	11802173
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR2T8 OR2T1 OR2T29 OR2T5 OR10AG1 OR2T12 OR2T6 OR5M1 OR2T33 OR2T4 OR2T35 OR4K1	2.06e-16	343	33	12	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR2T8 OR2T1 OR2T29 OR2T5 OR10AG1 OR2T12 OR2T6 OR5M1 OR2T33 OR2T4 OR2T35 OR4K1	2.29e-16	346	33	12	14611657
Pubmed	Expert curation of the human and mouse olfactory receptor gene repertoires identifies conserved coding regions split across two exons.	OR2T8 OR2T12 OR2T27 OR2T11 OR2T35 OR2T7	4.11e-12	46	33	6	32126975
Pubmed	DEFOG: a practical scheme for deciphering families of genes.	OR2T8 OR2T1 OR2T6 OR2T34 OR5M1 OR2T7 OR4K1	1.33e-09	219	33	7	12213199
Pubmed	Odorant and vomeronasal receptor genes in two mouse genome assemblies.	OR2T29 OR2T5 OR2T4 OR2T35	7.37e-07	74	33	4	15081110
Pubmed	Control of glioblastoma tumorigenesis by feed-forward cytokine signaling.	OSMR EGFR	8.73e-07	2	33	2	27110918
Pubmed	HDAC6 regulates epidermal growth factor receptor (EGFR) endocytic trafficking and degradation in renal epithelial cells.	EGFR PKD1	2.62e-06	3	33	2	23152903
Pubmed	Pioglitazone improves the phenotype and molecular defects of a targeted Pkd1 mutant.	EGFR PKD1	1.83e-05	7	33	2	12095915
Pubmed	The DNA sequence and biological annotation of human chromosome 1.	OR2T3 OR2T5 SMG5 OR2T12 OR2T34 OR2T33 OR2T7	4.29e-05	1031	33	7	16710414
Pubmed	Defining a link with autosomal-dominant polycystic kidney disease in mice with congenitally low expression of Pkd1.	EGFR PKD1	7.89e-05	14	33	2	16400024
Pubmed	Tsg101 Is Necessary for the Establishment and Maintenance of Mouse Retinal Pigment Epithelial Cell Polarity.	OPN1LW EGFR	2.58e-04	25	33	2	33795534
Interaction	OR2T12 interactions	OR2T12 OR2T33	1.48e-06	2	25	2	int:OR2T12
Interaction	OR2T33 interactions	OR2T12 OR2T33	4.43e-06	3	25	2	int:OR2T33
Cytoband	1q44	OR2T3 OR2T8 OR2T1 OR2T29 OR2T5 OR2T12 OR2T10 OR2T6 OR2T34 OR2T33 OR2T27 OR2T4 OR2T11 OR2T35 OR2T7	1.82e-31	110	33	15	1q44
Cytoband	Ensembl 112 genes in cytogenetic band chr1q44	OR2T3 OR2T8 OR2T1 OR2T29 OR2T5 OR2T12 OR2T10 OR2T6 OR2T34 OR2T33 OR2T27 OR2T4 OR2T11 OR2T35 OR2T7	2.03e-30	128	33	15	chr1q44
Cytoband	1p33	SLC6A9 CYP4Z1	2.94e-04	35	33	2	1p33
GeneFamily	Olfactory receptors, family 2	OR2T3 OR2T8 OR2T1 OR2T29 OR2T5 OR2T12 OR2T10 OR2T6 OR2T34 OR2T33 OR2T27 OR2T4 OR2T11 OR2T35 OR2T7	1.16e-26	113	28	15	149
ToppCell	TCGA-Endometrium-Primary_Tumor-Endometrial_Adenocarcinoma-Serous_adenocarcinoma-2\|TCGA-Endometrium / Sample_Type by Project: Shred V9	OR2T3 OR2T6 OR2T34 OR2T35 OR2T7	1.42e-08	105	33	5	744be8b4255bef3a973db7e4306e52387852e502
Disease	response to alcohol	OR2T8 EGFR	1.84e-03	75	25	2	EFO_0005526
Disease	Malignant mesothelioma	OSMR EGFR	3.84e-03	109	25	2	C0345967
Disease	Schizophrenia	MC5R BACE1 CNPPD1 SLC6A9	6.10e-03	883	25	4	C0036341
Disease	Non-Small Cell Lung Carcinoma	OSMR EGFR	7.69e-03	156	25	2	C0007131
Disease	Endometrioma	EGFR MYLIP	8.17e-03	161	25	2	C0269102
Disease	Endometriosis	EGFR MYLIP	8.17e-03	161	25	2	C0014175

Protein segments in the cluster

Peptide	Gene	Start	Entry
VMAAICALFMLPLCL	BACE1	461	P56817
VQSYMIVLMVTCCII	OPN1LW	216	P04000
LPMVFCVLLIMVMCY	OSMR	746	Q99650
EICYVTIIIPRMLMD	OR10AG1	61	Q8NH19
ETVMYVCCVLMLLIP	OR2T1	246	O43869
AMYICCVLMLLVPFS	OR2T12	196	Q8NG77
MYLCCVLMLLIPVVI	OR2T4	231	Q8NH00
TLMYLCCVLMLLIPV	OR2T5	201	Q6IEZ7
ETVMYVCCVAMLLIP	OR2T6	196	Q8NHC8
YVCCIMMLLIPFSVI	OR2T7	191	P0C7T2
AMYICCVLMLLVPFS	OR2T8	196	A6NH00
LPLVIELACMDTYEM	OR4K1	181	Q8NGD4
MLCYVTRPDAVLMEV	MYLIP	1	Q8WY64
VCCIMMLLIPFSVIS	OR2T27	201	Q8NH04
AMYICCVLMLLVPFS	OR2T33	196	Q8NG76
KMLTYLCCILMLLTP	OR2T34	201	Q8NGX1
ETLMYACCVLMLLIP	OR2T35	196	Q8NGX2
KTLMYLCCILMLLAP	OR2T3	201	Q8NH03
LCCILMLLAPIMVIS	OR2T3	206	Q8NH03
KIFMYLCCVIMLLIP	OR2T10	196	Q8NGZ9
TLMYLCCVLMLLIPV	OR2T29	201	Q8NH02
PPICTIDVYMIMVKC	EGFR	936	P00533
ISPCAMMLALVYIER	CNPPD1	91	Q9BV87
LILIMCNSVMDPLIY	MC5R	281	P33032
MCVIILMGLLTLYCC	SLC38A9	151	Q8NBW4
IVMLTCAVCLVTYMV	PKD1	3076	P98161
MYICCVLMLLIPISI	OR2T11	196	Q8NH01
PDLLIFQMVIICLMC	SMG5	351	Q9UPR3
MSKNICVCLVTIPYM	OR5M1	136	Q8NGP8
VIIVMCDLCIRYTIM	NCAPD3	961	P42695
QMPYTTMCIKECLRL	CYP4Z1	361	Q86W10
CEMCILVMKDILYLS	ZNF549	106	Q6P9A3
LYFILVVVLCCIMMS	SERINC5	41	Q86VE9
LVVISCIMCVAIMYI	SLC6A9	536	P48067