Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	histone H3K9 acetyltransferase activity	KAT2B KAT2A	1.00e-05	3	37	2	GO:0043992
GeneOntologyMolecularFunction	cyclin-dependent protein serine/threonine kinase regulator activity	CCNL2 KAT2B CCNL1	1.15e-04	51	37	3	GO:0016538
GeneOntologyMolecularFunction	histone H3 acetyltransferase activity	KAT2B KAT2A	3.46e-04	15	37	2	GO:0010484
GeneOntologyMolecularFunction	single-stranded DNA helicase activity	MCM5 POLQ	8.25e-04	23	37	2	GO:0017116
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ZNF805 TBX22 TBX18 KAT2B ZNF142 SALL2 ZNF226 SNAPC3 SALL3	1.11e-03	1459	37	9	GO:0000977
GeneOntologyMolecularFunction	histone acetyltransferase activity	KAT2B KAT2A	4.02e-03	51	37	2	GO:0004402
GeneOntologyMolecularFunction	peptide-lysine-N-acetyltransferase activity	KAT2B KAT2A	4.66e-03	55	37	2	GO:0061733
GeneOntologyMolecularFunction	peptide N-acetyltransferase activity	KAT2B KAT2A	5.53e-03	60	37	2	GO:0034212
GeneOntologyMolecularFunction	DNA helicase activity	MCM5 POLQ	5.89e-03	62	37	2	GO:0003678
GeneOntologyBiologicalProcess	regulation of centrosome cycle	CCNL2 KAT2B KAT2A CCNL1	4.33e-06	63	36	4	GO:0046605
GeneOntologyBiologicalProcess	negative regulation of centriole replication	KAT2B KAT2A	8.24e-05	8	36	2	GO:0046600
GeneOntologyBiologicalProcess	centrosome cycle	CCNL2 KAT2B KAT2A CCNL1	1.86e-04	164	36	4	GO:0007098
GeneOntologyBiologicalProcess	internal peptidyl-lysine acetylation	KAT2B KAT2A	1.93e-04	12	36	2	GO:0018393
GeneOntologyBiologicalProcess	negative regulation of centrosome duplication	KAT2B KAT2A	2.28e-04	13	36	2	GO:0010826
GeneOntologyBiologicalProcess	negative regulation of centrosome cycle	KAT2B KAT2A	2.28e-04	13	36	2	GO:0046606
GeneOntologyBiologicalProcess	microtubule organizing center organization	CCNL2 KAT2B KAT2A CCNL1	2.60e-04	179	36	4	GO:0031023
GeneOntologyBiologicalProcess	internal protein amino acid acetylation	KAT2B KAT2A	3.07e-04	15	36	2	GO:0006475
GeneOntologyBiologicalProcess	regulation of RNA splicing	CCNL2 KAT2B KAT2A CCNL1	4.51e-04	207	36	4	GO:0043484
GeneOntologyCellularComponent	ATAC complex	KAT2B KAT2A	2.74e-04	14	37	2	GO:0140672
Domain	Hist_acetylase_PCAF	KAT2B KAT2A	3.22e-06	2	34	2	IPR016376
Domain	PCAF_N	KAT2B KAT2A	3.22e-06	2	34	2	IPR009464
Domain	PCAF_N	KAT2B KAT2A	3.22e-06	2	34	2	PF06466
Domain	Cyclin_L/T	CCNL2 CCNL1	8.95e-05	8	34	2	IPR015429
Domain	-	ZNF805 ZNF462 ZNF407 ZNF142 SALL2 ZNF226 SALL3	1.86e-04	679	34	7	3.30.160.60
Domain	zf-C2H2	ZNF805 ZNF462 ZNF407 ZNF142 SALL2 ZNF226 SALL3	2.11e-04	693	34	7	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	ZNF805 ZNF462 ZNF407 ZNF142 SALL2 ZNF226 SALL3	2.12e-04	694	34	7	IPR013087
Domain	ZINC_FINGER_C2H2_2	ZNF805 ZNF462 ZNF407 ZNF142 SALL2 ZNF226 SALL3	4.16e-04	775	34	7	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF805 ZNF462 ZNF407 ZNF142 SALL2 ZNF226 SALL3	4.22e-04	777	34	7	PS00028
Domain	TF_T-box	TBX22 TBX18	4.30e-04	17	34	2	IPR001699
Domain	TBOX_3	TBX22 TBX18	4.30e-04	17	34	2	PS50252
Domain	TBOX	TBX22 TBX18	4.30e-04	17	34	2	SM00425
Domain	Cyclin_C-dom	CCNL2 CCNL1	4.30e-04	17	34	2	IPR004367
Domain	TF_T-box_CS	TBX22 TBX18	4.30e-04	17	34	2	IPR018186
Domain	T-box	TBX22 TBX18	4.30e-04	17	34	2	PF00907
Domain	-	TBX22 TBX18	4.30e-04	17	34	2	2.60.40.820
Domain	TBOX_1	TBX22 TBX18	4.30e-04	17	34	2	PS01283
Domain	Cyclin_C	CCNL2 CCNL1	4.30e-04	17	34	2	PF02984
Domain	Cyclin_C	CCNL2 CCNL1	4.30e-04	17	34	2	SM01332
Domain	TBOX_2	TBX22 TBX18	4.30e-04	17	34	2	PS01264
Domain	Znf_C2H2-like	ZNF805 ZNF462 ZNF407 ZNF142 SALL2 ZNF226 SALL3	4.88e-04	796	34	7	IPR015880
Domain	Znf_C2H2	ZNF805 ZNF462 ZNF407 ZNF142 SALL2 ZNF226 SALL3	5.22e-04	805	34	7	IPR007087
Domain	ZnF_C2H2	ZNF805 ZNF462 ZNF407 ZNF142 SALL2 ZNF226 SALL3	5.34e-04	808	34	7	SM00355
Domain	Acetyltransf_1	KAT2B KAT2A	7.95e-04	23	34	2	PF00583
Domain	GNAT	KAT2B KAT2A	9.40e-04	25	34	2	PS51186
Domain	GNAT_dom	KAT2B KAT2A	9.40e-04	25	34	2	IPR000182
Domain	Bromodomain_CS	KAT2B KAT2A	1.02e-03	26	34	2	IPR018359
Domain	CYCLINS	CCNL2 CCNL1	1.18e-03	28	34	2	PS00292
Domain	Cyclin_N	CCNL2 CCNL1	1.64e-03	33	34	2	IPR006671
Domain	Cyclin_N	CCNL2 CCNL1	1.64e-03	33	34	2	PF00134
Domain	BROMODOMAIN_1	KAT2B KAT2A	2.06e-03	37	34	2	PS00633
Domain	CYCLIN	CCNL2 CCNL1	2.17e-03	38	34	2	SM00385
Domain	Bromodomain	KAT2B KAT2A	2.17e-03	38	34	2	PF00439
Domain	-	CCNL2 CCNL1	2.40e-03	40	34	2	1.10.472.10
Domain	-	KAT2B KAT2A	2.40e-03	40	34	2	3.40.630.30
Domain	BROMODOMAIN_2	KAT2B KAT2A	2.52e-03	41	34	2	PS50014
Domain	BROMO	KAT2B KAT2A	2.65e-03	42	34	2	SM00297
Domain	Bromodomain	KAT2B KAT2A	2.65e-03	42	34	2	IPR001487
Domain	-	KAT2B KAT2A	2.65e-03	42	34	2	1.20.920.10
Domain	Cyclin-like	CCNL2 CCNL1	2.77e-03	43	34	2	IPR013763
Domain	Acyl_CoA_acyltransferase	KAT2B KAT2A	3.03e-03	45	34	2	IPR016181
Domain	-	POLQ EXD2	3.30e-03	47	34	2	3.30.420.10
Domain	p53-like_TF_DNA-bd	TBX22 TBX18	4.18e-03	53	34	2	IPR008967
Domain	RNaseH-like_dom	POLQ EXD2	6.99e-03	69	34	2	IPR012337
Domain	4_helix_cytokine-like_core	ZNF142 SACS	8.00e-03	74	34	2	IPR009079
Pathway	REACTOME_RUNX3_REGULATES_NOTCH_SIGNALING	KAT2B KAT2A	1.04e-04	10	22	2	MM15535
Pathway	REACTOME_RUNX3_REGULATES_NOTCH_SIGNALING	KAT2B KAT2A	2.09e-04	14	22	2	M27808
Pathway	PID_SMAD2_3NUCLEAR_PATHWAY	SIN3B KAT2B KAT2A	2.70e-04	82	22	3	M2
Pathway	REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_LATE_STAGE_BRANCHING_MORPHOGENESIS_PANCREATIC_BUD_PRECURSOR_CELLS	KAT2B KAT2A	2.75e-04	16	22	2	M27121
Pathway	REACTOME_SIGNALING_BY_NOTCH1	KAT2B KAT2A	3.50e-04	18	22	2	MM14775
Pathway	REACTOME_NOTCH4_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION	KAT2B KAT2A	4.34e-04	20	22	2	M27881
Pathway	REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY	KAT2B KAT2A	5.77e-04	23	22	2	MM14954
Pathway	REACTOME_NOTCH3_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION	KAT2B KAT2A	6.82e-04	25	22	2	M27880
Pathway	REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY	KAT2B KAT2A	8.57e-04	28	22	2	M6177
Pathway	REACTOME_POSITIVE_EPIGENETIC_REGULATION_OF_RRNA_EXPRESSION	KAT2B KAT2A	9.85e-04	30	22	2	MM15173
Pathway	REACTOME_FORMATION_OF_WDR5_CONTAINING_HISTONE_MODIFYING_COMPLEXES	KAT2B KAT2A	1.58e-03	38	22	2	MM17073
Pathway	REACTOME_TRANSCRIPTIONAL_REGULATION_BY_RUNX1	AUTS2 SIN3B KAT2B	1.66e-03	153	22	3	MM15522
Pathway	REACTOME_SIGNALING_BY_NOTCH	KAT2B KAT2A	1.66e-03	39	22	2	MM14604
Pathway	REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT	KAT2B KAT2A	1.93e-03	42	22	2	M17541
Pathway	REACTOME_FORMATION_OF_WDR5_CONTAINING_HISTONE_MODIFYING_COMPLEXES	KAT2B KAT2A	1.93e-03	42	22	2	M48018
Pathway	REACTOME_RUNX1_REGULATES_GENES_INVOLVED_IN_MEGAKARYOCYTE_DIFFERENTIATION_AND_PLATELET_FUNCTION	SIN3B KAT2B	2.11e-03	44	22	2	MM15527
Pathway	WP_NOTCH_SIGNALING_WP268	KAT2B KAT2A	2.21e-03	45	22	2	M39571
Pathway	WP_NOTCH_SIGNALING_PATHWAY	KAT2B KAT2A	2.31e-03	46	22	2	MM15971
Pathway	KEGG_NOTCH_SIGNALING_PATHWAY	KAT2B KAT2A	2.41e-03	47	22	2	M7946
Pathway	REACTOME_RNA_POLYMERASE_I_TRANSCRIPTION_INITIATION	KAT2B KAT2A	2.41e-03	47	22	2	M1095
Pathway	REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION	KAT2B KAT2A	2.51e-03	48	22	2	M611
Pathway	REACTOME_SIGNALING_BY_NOTCH3	KAT2B KAT2A	2.62e-03	49	22	2	M618
Pathway	REACTOME_SIGNALING_BY_NOTCH1_PEST_DOMAIN_MUTANTS_IN_CANCER	KAT2B KAT2A	3.65e-03	58	22	2	M29616
Pathway	REACTOME_GENE_EXPRESSION_TRANSCRIPTION	AUTS2 SIN3B KAT2B KAT2A ZNF226 SNAPC3	3.89e-03	1022	22	6	MM15436
Pathway	PID_HDAC_CLASSI_PATHWAY	SIN3B KAT2B	4.69e-03	66	22	2	M101
Pathway	REACTOME_FORMATION_OF_PARAXIAL_MESODERM	KAT2B KAT2A	5.12e-03	69	22	2	M46439
Pathway	REACTOME_TRANSCRIPTIONAL_REGULATION_BY_RUNX1	AUTS2 SIN3B KAT2B	5.71e-03	237	22	3	M27786
Pathway	PID_E2F_PATHWAY	KAT2B KAT2A	5.71e-03	73	22	2	M40
Pathway	REACTOME_GENERIC_TRANSCRIPTION_PATHWAY	AUTS2 SIN3B KAT2B KAT2A ZNF226	5.74e-03	768	22	5	MM14851
Pathway	REACTOME_SIGNALING_BY_NOTCH1	KAT2B KAT2A	5.87e-03	74	22	2	M616
Pathway	REACTOME_TRANSCRIPTIONAL_REGULATION_BY_RUNX3	KAT2B KAT2A	6.18e-03	76	22	2	MM15520
Pubmed	Transcriptional coactivator p300/CBP-associated factor and p300/CBP-associated factor type B are required for normal estrogen response of the mouse uterus.	KAT2B KAT2A	1.10e-06	2	37	2	15502373
Pubmed	Distinct but overlapping roles of histone acetylase PCAF and of the closely related PCAF-B/GCN5 in mouse embryogenesis.	KAT2B KAT2A	1.10e-06	2	37	2	11027331
Pubmed	Divergent functions of histone acetyltransferases KAT2A and KAT2B in keratinocyte self-renewal and differentiation.	KAT2B KAT2A	1.10e-06	2	37	2	37259855
Pubmed	Influenza A virus nucleoprotein is acetylated by histone acetyltransferases PCAF and GCN5.	KAT2B KAT2A	1.10e-06	2	37	2	29555684
Pubmed	Acetylation of the influenza A virus polymerase subunit PA in the N-terminal domain positively regulates its endonuclease activity.	KAT2B KAT2A	1.10e-06	2	37	2	34270849
Pubmed	Gcn5 and PCAF negatively regulate interferon-β production through HAT-independent inhibition of TBK1.	KAT2B KAT2A	1.10e-06	2	37	2	25269644
Pubmed	Differential Effects of Histone Acetyltransferase GCN5 or PCAF Knockdown on Urothelial Carcinoma Cells.	KAT2B KAT2A	1.10e-06	2	37	2	28678170
Pubmed	Characterization and in vivo pharmacological rescue of a Wnt2-Gata6 pathway required for cardiac inflow tract development.	TBX18 SALL2 SALL3	1.93e-06	23	37	3	20159597
Pubmed	Characterization of cyclin L1 and L2 interactions with CDK11 and splicing factors: influence of cyclin L isoforms on splice site selection.	CCNL2 CCNL1	3.30e-06	3	37	2	18216018
Pubmed	KAT2A/KAT2B-targeted acetylome reveals a role for PLK4 acetylation in preventing centrosome amplification.	KAT2B KAT2A	3.30e-06	3	37	2	27796307
Pubmed	Acetylation of interferon regulatory factor-7 by p300/CREB-binding protein (CBP)-associated factor (PCAF) impairs its DNA binding.	KAT2B KAT2A	3.30e-06	3	37	2	12374802
Pubmed	CDK13/CDC2L5 interacts with L-type cyclins and regulates alternative splicing.	CCNL2 CCNL1	3.30e-06	3	37	2	17261272
Pubmed	Acetylation of conserved lysines in the catalytic core of cyclin-dependent kinase 9 inhibits kinase activity and regulates transcription.	KAT2B KAT2A	3.30e-06	3	37	2	18250157
Pubmed	Acetylation of TBX5 by KAT2B and KAT2A regulates heart and limb development.	KAT2B KAT2A	3.30e-06	3	37	2	29174768
Pubmed	In-vitro acetylation of SARS-CoV and SARS-CoV-2 nucleocapsid proteins by human PCAF and GCN5.	KAT2B KAT2A	3.30e-06	3	37	2	33894414
Pubmed	Characterization of cyclin L1 as an immobile component of the splicing factor compartment.	CCNL2 CCNL1	3.30e-06	3	37	2	17494991
Pubmed	Tat acetyl-acceptor lysines are important for human immunodeficiency virus type-1 replication.	KAT2B KAT2A	3.30e-06	3	37	2	11956210
Pubmed	GCN5 inhibits XBP-1S-mediated transcription by antagonizing PCAF action.	KAT2B KAT2A	3.30e-06	3	37	2	25426559
Pubmed	Expression of three spalt (sal) gene homologues in zebrafish embryos.	SALL2 SALL3	3.30e-06	3	37	2	12590351
Pubmed	Increased expression of a 58-kDa protein kinase leads to changes in the CHO cell cycle.	CCNL2 CCNL1	6.60e-06	4	37	2	2217177
Pubmed	The transcriptional co-activator PCAF regulates cdk2 activity.	KAT2B KAT2A	6.60e-06	4	37	2	19773423
Pubmed	Intracellular interleukin-1alpha functionally interacts with histone acetyltransferase complexes.	KAT2B KAT2A	6.60e-06	4	37	2	14612453
Pubmed	Regulation and function of Spalt proteins during animal development.	SALL2 SALL3	6.60e-06	4	37	2	19247946
Pubmed	The vertebrate spalt genes in development and disease.	SALL2 SALL3	6.60e-06	4	37	2	16545361
Pubmed	Proper Gcn5 histone acetyltransferase expression is required for normal anteroposterior patterning of the mouse skeleton.	KAT2B KAT2A	6.60e-06	4	37	2	18430026
Pubmed	The histone acetylase PCAF is a phorbol-ester-inducible coactivator of the IRF family that confers enhanced interferon responsiveness.	KAT2B KAT2A	6.60e-06	4	37	2	10022868
Pubmed	P/CAF and GCN5 acetylate the AML1/MDS1/EVI1 fusion oncoprotein.	KAT2B KAT2A	6.60e-06	4	37	2	12878208
Pubmed	CDK11(p58) kinase activity is required to protect sister chromatid cohesion at centromeres in mitosis.	CCNL2 CCNL1	6.60e-06	4	37	2	24436071
Pubmed	Glucocorticoid-stimulated preadipocyte differentiation is mediated through acetylation of C/EBPbeta by GCN5.	KAT2B KAT2A	6.60e-06	4	37	2	17301242
Pubmed	Dopamine and glutamate induce distinct striatal splice forms of Ania-6, an RNA polymerase II-associated cyclin.	CCNL2 CCNL1	1.10e-05	5	37	2	11683997
Pubmed	Functional interaction between the mouse notch1 intracellular region and histone acetyltransferases PCAF and GCN5.	KAT2B KAT2A	1.10e-05	5	37	2	10747963
Pubmed	Identification and mapping of human histone acetylation modifier gene homologues.	KAT2B KAT2A	1.10e-05	5	37	2	9722949
Pubmed	CDK11(p58) protein kinase activity is associated with Bcl-2 down-regulation in pro-apoptosis pathway.	CCNL2 CCNL1	1.10e-05	5	37	2	17516030
Pubmed	Regulation of insulin gene transcription by multiple histone acetyltransferases.	KAT2B KAT2A	1.10e-05	5	37	2	21774670
Pubmed	Acetyltransferases GCN5 and PCAF Are Required for B Lymphocyte Maturation in Mice.	KAT2B KAT2A	1.10e-05	5	37	2	35053209
Pubmed	Ada3 requirement for HAT recruitment to estrogen receptors and estrogen-dependent breast cancer cell proliferation.	KAT2B KAT2A	1.10e-05	5	37	2	18089809
Pubmed	Gcn5 and PCAF regulate PPARγ and Prdm16 expression to facilitate brown adipogenesis.	KAT2B KAT2A	1.10e-05	5	37	2	25071153
Pubmed	Distinct roles of GCN5/PCAF-mediated H3K9ac and CBP/p300-mediated H3K18/27ac in nuclear receptor transactivation.	KAT2B KAT2A	1.10e-05	5	37	2	21131905
Pubmed	p/CAF modulates the activity of the transcription factor p48/Ptf1a involved in pancreatic acinar differentiation.	KAT2B KAT2A	1.10e-05	5	37	2	18834332
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	ZNF462 RGL1 ZNF407 SIN3B CTIF SACS	1.26e-05	493	37	6	15368895
Pubmed	Mammalian GCN5 and P/CAF acetyltransferases have homologous amino-terminal domains important for recognition of nucleosomal substrates.	KAT2B KAT2A	1.65e-05	6	37	2	9742083
Pubmed	The stability of histone acetyltransferase general control non-derepressible (Gcn) 5 is regulated by Cullin4-RING E3 ubiquitin ligase.	KAT2B KAT2A	1.65e-05	6	37	2	21987584
Pubmed	Zinc finger protein sall2 is not essential for embryonic and kidney development.	SALL2 SALL3	1.65e-05	6	37	2	12482961
Pubmed	Sir2 regulates skeletal muscle differentiation as a potential sensor of the redox state.	KAT2B KAT2A	1.65e-05	6	37	2	12887892
Pubmed	Tat-controlled protein acetylation.	KAT2B KAT2A	1.65e-05	6	37	2	12154097
Pubmed	Corepressor CtBP1 interacts with and specifically inhibits CBP activity.	KAT2B KAT2A	1.65e-05	6	37	2	16122695
Pubmed	Regulation of transforming growth factor-beta and bone morphogenetic protein signalling by transcriptional coactivator GCN5.	KAT2B KAT2A	2.30e-05	7	37	2	15009097
Pubmed	The transforming acidic coiled coil proteins interact with nuclear histone acetyltransferases.	KAT2B KAT2A	2.30e-05	7	37	2	14767476
Pubmed	A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A.	KAT2B KAT2A	3.07e-05	8	37	2	8684459
Pubmed	H3 ubiquitination by NEDD4 regulates H3 acetylation and tumorigenesis.	KAT2B KAT2A	3.07e-05	8	37	2	28300060
Pubmed	Characterization of cyclin L2, a novel cyclin with an arginine/serine-rich domain: phosphorylation by DYRK1A and colocalization with splicing factors.	CCNL2 CCNL1	3.95e-05	9	37	2	14623875
Pubmed	Chromatin "prepattern" and histone modifiers in a fate choice for liver and pancreas.	KAT2B KAT2A	3.95e-05	9	37	2	21596989
Pubmed	AML1 is functionally regulated through p300-mediated acetylation on specific lysine residues.	KAT2B KAT2A	3.95e-05	9	37	2	14752096
Pubmed	UV-Induced RPA1 Acetylation Promotes Nucleotide Excision Repair.	KAT2B KAT2A	3.95e-05	9	37	2	28854355
Pubmed	Combinatorial CRISPR screen identifies fitness effects of gene paralogues.	CCNL2 KAT2B KAT2A CCNL1	4.56e-05	186	37	4	33637726
Pubmed	GCN5 and p300 share essential functions during early embryogenesis.	KAT2B KAT2A	4.93e-05	10	37	2	15937931
Pubmed	Loss of Gcn5l2 leads to increased apoptosis and mesodermal defects during mouse development.	KAT2B KAT2A	4.93e-05	10	37	2	11017084
Pubmed	SAGA and ATAC histone acetyl transferase complexes regulate distinct sets of genes and ATAC defines a class of p300-independent enhancers.	KAT2B KAT2A	6.02e-05	11	37	2	22055187
Pubmed	Glucagon regulates gluconeogenesis through KAT2B- and WDR5-mediated epigenetic effects.	KAT2B KAT2A	6.02e-05	11	37	2	24051374
Pubmed	Acetylation of HIV-1 integrase by p300 regulates viral integration.	KAT2B KAT2A	6.02e-05	11	37	2	16096645
Pubmed	The metazoan ATAC and SAGA coactivator HAT complexes regulate different sets of inducible target genes.	KAT2B KAT2A	6.02e-05	11	37	2	19936620
Pubmed	Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination.	SIN3B KAT2B KAT2A	7.10e-05	75	37	3	25593309
Pubmed	Chromatin dynamics associated with HIV-1 Tat-activated transcription.	KAT2B KAT2A	7.22e-05	12	37	2	19716452
Pubmed	Murine homolog of SALL1 is essential for ureteric bud invasion in kidney development.	SALL2 SALL3	7.22e-05	12	37	2	11688560
Pubmed	The ATAC acetyl transferase complex controls mitotic progression by targeting non-histone substrates.	KAT2B KAT2A	8.53e-05	13	37	2	20562830
Pubmed	Novel subunits of the TATA binding protein free TAFII-containing transcription complex identified by matrix-assisted laser desorption/ionization-time of flight mass spectrometry following one-dimensional gel electrophoresis.	KAT2B KAT2A	1.15e-04	15	37	2	12601814
Pubmed	The HIV-1 Tat team gets bigger.	KAT2B KAT2A	1.67e-04	18	37	2	20227660
Pubmed	Murine inner cell mass-derived lineages depend on Sall4 function.	SALL2 SALL3	1.67e-04	18	37	2	17060609
Pubmed	Identification of TATA-binding protein-free TAFII-containing complex subunits suggests a role in nucleosome acetylation and signal transduction.	KAT2B KAT2A	2.07e-04	20	37	2	10373431
Pubmed	Analysis of FGF20-regulated genes in organ of Corti progenitors by translating ribosome affinity purification.	SALL2 SALL3	2.28e-04	21	37	2	32492250
Pubmed	Supt20 is required for development of the axial skeleton.	TBX18 KAT2A	2.28e-04	21	37	2	27894818
Pubmed	Systematic Analysis of the Functions of Lysine Acetylation in the Regulation of Tat Activity.	KAT2B KAT2A	2.51e-04	22	37	2	23826228
Pubmed	A functional cellular framework for sex and estrous cycle-dependent gene expression and behavior.	AUTS2 LAMP5	2.75e-04	23	37	2	35065713
Pubmed	Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers.	SIN3B KAT2B KAT2A	3.15e-04	124	37	3	20850016
Pubmed	Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel NC2-like histone fold module that interacts with the TATA-binding protein.	KAT2B KAT2A	3.80e-04	27	37	2	18838386
Pubmed	A cooperative activation loop among SWI/SNF, gamma-H2AX and H3 acetylation for DNA double-strand break repair.	KAT2B KAT2A	4.09e-04	28	37	2	20224553
Pubmed	The human SPT20-containing SAGA complex plays a direct role in the regulation of endoplasmic reticulum stress-induced genes.	KAT2B KAT2A	4.09e-04	28	37	2	19114550
Pubmed	A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing.	KAT2B KAT2A	4.70e-04	30	37	2	18206972
Pubmed	Gene-smoking interactions identify several novel blood pressure loci in the Framingham Heart Study.	CDH19 SACS	5.35e-04	32	37	2	25189868
Pubmed	Keratin 13 deficiency causes white sponge nevus in mice.	CCNL2 CCNL1	5.69e-04	33	37	2	32758484
Pubmed	Tbx3 controls the fate of hepatic progenitor cells in liver development by suppressing p19ARF expression.	TBX22 TBX18	5.69e-04	33	37	2	18356246
Pubmed	Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo.	KAT2B KAT2A	5.69e-04	33	37	2	11564863
Pubmed	The CARM1-p300-c-Myc-Max (CPCM) transcriptional complex regulates the expression of CUL4A/4B and affects the stability of CRL4 E3 ligases in colorectal cancer.	DENND4A KAT2A	5.69e-04	33	37	2	32140074
Pubmed	An Oct4-centered protein interaction network in embryonic stem cells.	ZNF462 SALL2 SALL3	7.49e-04	167	37	3	20362541
Pubmed	A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.	ZNF462 SIN3B KAT2A SALL2 ZNF226	8.82e-04	709	37	5	22988430
Pubmed	FBXL13 directs the proteolysis of CEP192 to regulate centrosome homeostasis and cell migration.	RGL1 SACS	9.23e-04	42	37	2	29348145
Pubmed	ATAC and SAGA co-activator complexes utilize co-translational assembly, but their cellular localization properties and functions are distinct.	KAT2B KAT2A	1.01e-03	44	37	2	37682711
Interaction	ING1 interactions	SIN3B KAT2B SALL2 SALL3 SCLT1	1.05e-06	103	36	5	int:ING1
Interaction	MAGEA9 interactions	CCNL2 KAT2A SALL2 SALL3 POLQ	3.24e-05	208	36	5	int:MAGEA9
Cytoband	18q23	ZNF407 SALL3	2.53e-04	29	37	2	18q23
Cytoband	Ensembl 112 genes in cytogenetic band chr18q22	ZNF407 CDH19	1.35e-03	67	37	2	chr18q22
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF805 ZNF462 ZNF407 ZNF142 SALL2 ZNF226 SALL3	5.14e-05	718	26	7	28
GeneFamily	ATAC complex	KAT2B KAT2A	1.54e-04	13	26	2	1058
GeneFamily	Zinc fingers ZZ-type\|Lysine acetyltransferases	KAT2B KAT2A	2.67e-04	17	26	2	486
GeneFamily	Lysine acetyltransferases\|ATAC complex\|SAGA complex\|GCN5 related N-acetyltransferases	KAT2B KAT2A	2.67e-04	17	26	2	1059
GeneFamily	T-boxes	TBX22 TBX18	3.00e-04	18	26	2	766
GeneFamily	GCN5 related N-acetyltransferases	KAT2B KAT2A	5.38e-04	24	26	2	1134
GeneFamily	Cyclins	CCNL2 CCNL1	7.35e-04	28	26	2	473
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	SACS PREX2	2.77e-02	181	26	2	694
CoexpressionAtlas	DevelopingGonad_e11.5_ovary + mesonephros_emap-3226_k-means-cluster#1_top-relative-expression-ranked_500	TBX18 RGL1 SNAPC3 PREX2	1.53e-05	89	36	4	gudmap_developingGonad_e11.5_ovary + mesonephros_k1_500
ToppCell	wk_15-18-Epithelial-PNS-Schwann_precursor\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	TBX22 AUTS2 CDH19 SACS	1.24e-05	177	36	4	5357359e6c2161a37f39a6b3b78449f5cbc327d1
ToppCell	primary_auditory_cortex_(A1C)-Non-neuronal-Macroglial-Oligo-OPC-OPC_L1-6_MYT1\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ZNF462 KAT2B SALL3 PREX2	1.47e-05	185	36	4	efc5d564f8793c751ba640aef60f761e4b081d3f
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial-Oligo-OPC\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ZNF462 KAT2B SALL3 PREX2	1.47e-05	185	36	4	7aaa8335b40927e3e8fdcede807cd521fc213a0d
ToppCell	primary_auditory_cortex_(A1C)-Non-neuronal-Macroglial-Oligo-OPC\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ZNF462 KAT2B SALL3 PREX2	1.47e-05	185	36	4	fba2dc46cd98ab9c78e788959c2121aa10d148b2
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial-Oligo-OPC-OPC_L1-6_MYT1\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ZNF462 KAT2B SALL3 PREX2	1.47e-05	185	36	4	2e1766f1a972fecd670daaaf7eb2d3a404f121e7
ToppCell	RA-14._Fibroblast_III\|RA / Chamber and Cluster_Paper	TBX18 CDH19 SCLT1 CCNL1	1.60e-05	189	36	4	46e9a58aacd79db5a02898a8c7244e1884adcfd1
ToppCell	RA-14._Fibroblast_III\|World / Chamber and Cluster_Paper	TBX18 CDH19 SCLT1 CCNL1	1.60e-05	189	36	4	b6e12d24d2b0735730bdc625f8318c1c9c2a9b3b
Disease	balding measurement	ZNF462 AUTS2 TBX18 MCM5 KAT2B CTIF	3.59e-04	792	36	6	EFO_0007825
Disease	Burkitt Lymphoma	AUTS2 SALL3	8.88e-04	36	36	2	C0006413
Disease	heart disease (implicated_via_orthology)	KAT2B KAT2A	9.90e-04	38	36	2	DOID:114 (implicated_via_orthology)
Disease	kidney disease (implicated_via_orthology)	KAT2B KAT2A	1.15e-03	41	36	2	DOID:557 (implicated_via_orthology)
Disease	interleukin 12 measurement	ZNF462 SACS	1.92e-03	53	36	2	EFO_0004753
Disease	carcinoma (implicated_via_orthology)	SALL2 SALL3	2.78e-03	64	36	2	DOID:305 (implicated_via_orthology)
Disease	R-warfarin measurement	TBX18 ZNF142 SCLT1	4.11e-03	265	36	3	EFO_0803324
Disease	chronotype measurement	ZNF462 AUTS2 RGL1 MCM5 CDH19	4.12e-03	882	36	5	EFO_0008328
Disease	irritability measurement	AUTS2 CDH19	4.52e-03	82	36	2	EFO_0009594
Disease	descending aortic diameter	TBX18 CTIF	5.19e-03	88	36	2	EFO_0021788
Disease	smoking cessation	AUTS2 EXD2 CCNL1	7.22e-03	325	36	3	EFO_0004319
Disease	reticulocyte count	RGL1 AMPD3 KAT2B CTIF DENND4A	8.36e-03	1045	36	5	EFO_0007986
Disease	reticulocyte measurement	RGL1 AMPD3 KAT2B CTIF DENND4A	8.63e-03	1053	36	5	EFO_0010700
Disease	cognitive function measurement, self reported educational attainment	AUTS2 DENND4A EXD2	9.19e-03	355	36	3	EFO_0004784, EFO_0008354
Disease	Colorectal Carcinoma	TBX22 SALL3 SACS PREX2	1.02e-02	702	36	4	C0009402

Protein segments in the cluster

Peptide	Gene	Start	Entry
QVAHQKPHASMDKHP	DAP	76	P51397
YHPMPHEVEIAHTKK	CTIF	171	O43310
KEQEKEKHHVHLVMY	C1orf216	161	Q8TAB5
VHVKHPHKIIVMYLQ	CCNL1	196	Q9UK58
HGNVLQYHKDVKHMN	BPNT1	266	O95861
VYDNKKMLEHQEPHS	AMPD3	231	Q01432
AHTQKYPMVHLLQKS	DENND4A	1741	Q7Z401
TYMDAQLFKKVVPHH	RGL1	241	Q9NZL6
GTHLMNHLKEYHIKH	KAT2A	591	Q92830
GTHLMNHLKEYHIKH	KAT2B	586	Q92831
QKYPEHAIHKVLQLM	MCM5	701	P33992
PQTHSNHIYHMIKLG	HSP90AB3P	546	Q58FF7
KHFPIEMKDHNSHDV	EXD2	441	Q9NVH0
YHHQQKVKKQMQSDP	AUTS2	661	Q8WXX7
YHVHHKMTANQVQIP	LAMP5	256	Q9UJQ1
VHVKHPHKIIVMYLQ	CCNL2	191	Q96S94
GSKNQNVYMKHHDIH	POLQ	1176	O75417
KKHMLLAHHQVQPFA	SALL2	956	Q9Y467
HFQRHKEKYPHIQMN	SALL3	466	Q9BXA9
QPYLHNVPKTMAKFH	SACS	1301	Q9NZJ4
VKNHHVPEQLMKYHT	CDH19	336	Q9H159
EKHLQVIGYEKMIHH	PRSS58	76	Q8IYP2
MHSVQKNEHDKTPEH	SIN3B	251	O75182
MNHVVKHNHTAVTKV	OR8K1	1	Q8NGG5
IFHKHKEHKPYQTML	SNAPC3	191	Q92966
LKVMESHHQHKPTEN	TSGA13	126	Q96PP4
HSMHKYQPRVHVIRK	TBX18	261	O95935
HIILQSMHKYKPRVH	TBX22	211	Q9Y458
QTPMNHKKTHFHQVL	TTC41P	691	Q6P2S7
HVTDKHQFKPEQMLY	PREX2	446	Q70Z35
LHKLYQEHMTEAQIH	SCLT1	161	Q96NL6
HLQTHQKVHVIEKPY	ZNF226	321	Q9NYT6
NMHSVLVHYQKKHPE	ZNF462	1041	Q96JM2
AYQDHVGKMHAHEKI	ZNF142	386	P52746
HMHIKQAHGPQKVFS	ZNF407	231	Q9C0G0
TQPMTQHLHVTYKKV	THAP4	561	Q8WY91
LLQHHMVHTGEKPYK	ZNF805	246	Q5CZA5