Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionbenzodiazepine receptor binding

RIMBP3 RIMBP3C RIMBP3B

4.29e-075713GO:0030156
GeneOntologyMolecularFunctionDNA-binding transcription factor activity, RNA polymerase II-specific

ALX3 SCRT2 ZNF384 MLXIPL HOXB3 ATF6 KMT2D RARA RARB AEBP1 GLI1 ZKSCAN2 PLSCR2 ZNF619 GRHL3

1.08e-0414127115GO:0000981
GeneOntologyCellularComponentmanchette

RIMBP3 RIMBP3C RIMBP3B

1.11e-0428703GO:0002177
MousePhenofusion of atlas and odontoid process

HOXB3 RARA RARB

7.16e-0610563MP:0010701
MousePhenoabnormal manchette morphology

RIMBP3 CCDC146 RIMBP3C RIMBP3B

3.05e-0545564MP:0009376
MousePhenoabnormal odontoid process morphology

HOXB3 RARA RARB

4.76e-0518563MP:0004659
MousePhenoectopic manchette

RIMBP3 RIMBP3C RIMBP3B

5.64e-0519563MP:0009377
MousePhenodetached sperm flagellum

RIMBP3 RIMBP3C RIMBP3B

7.70e-0521563MP:0008893
MousePhenoabnormal spermatid morphology

RIMBP3 RARA CCDC146 WIPF3 RIMBP3C RIMBP3B

2.22e-04217566MP:0006380
DomainSH3_9

RIMBP3 EFS RIMBP3C RIMBP3B ARHGAP33

1.09e-0578705PF14604
DomainSH3_2

RIMBP3 CASKIN2 RIMBP3C RIMBP3B ARHGAP33

1.76e-0586705IPR011511
DomainSH3_2

RIMBP3 CASKIN2 RIMBP3C RIMBP3B ARHGAP33

1.76e-0586705PF07653
DomainRetinoic_acid_rcpt

RARA RARB

8.27e-054702IPR003078
DomainSH3

RIMBP3 EFS CASKIN2 RIMBP3C RIMBP3B ARHGAP33

1.58e-04216706SM00326
DomainSH3

RIMBP3 EFS CASKIN2 RIMBP3C RIMBP3B ARHGAP33

1.58e-04216706PS50002
DomainSH3_domain

RIMBP3 EFS CASKIN2 RIMBP3C RIMBP3B ARHGAP33

1.75e-04220706IPR001452
DomainTIL

VWF SSPOP

8.92e-0412702PF01826
DomainC8

VWF SSPOP

8.92e-0412702PF08742
DomainUnchr_dom_Cys-rich

VWF SSPOP

1.05e-0313702IPR014853
DomainC8

VWF SSPOP

1.05e-0313702SM00832
DomainTIL_dom

VWF SSPOP

1.22e-0314702IPR002919
DomainVWD

VWF SSPOP

1.61e-0316702SM00216
DomainVWF_type-D

VWF SSPOP

1.61e-0316702IPR001846
DomainVWFD

VWF SSPOP

1.61e-0316702PS51233
DomainVWD

VWF SSPOP

1.61e-0316702PF00094
DomainCTCK_1

VWF SSPOP

2.04e-0318702PS01185
DomainVWC_out

VWF SSPOP

2.27e-0319702SM00215
DomainFA58C

AEBP1 SSPOP

2.78e-0321702SM00231
DomainFA58C_3

AEBP1 SSPOP

2.78e-0321702PS50022
DomainFA58C_1

AEBP1 SSPOP

2.78e-0321702PS01285
DomainFA58C_2

AEBP1 SSPOP

2.78e-0321702PS01286
DomainF5_F8_type_C

AEBP1 SSPOP

3.62e-0324702PF00754
DomainFA58C

AEBP1 SSPOP

3.62e-0324702IPR000421
DomainCys_knot_C

VWF SSPOP

3.93e-0325702IPR006207
DomainCTCK_2

VWF SSPOP

3.93e-0325702PS01225
PathwayWP_DEVELOPMENT_OF_URETERIC_COLLECTION_SYSTEM

GREB1L RARA RARB GLI1

4.61e-0560474M40048
PathwayWP_VITAMIN_A1_AND_A5X_PATHWAYS

RARA RARB

1.62e-046472M48097
Pubmed

RIM-BP3 is a manchette-associated protein essential for spermiogenesis.

RIMBP3 RIMBP3C RIMBP3B

3.26e-08471319091768
Pubmed

Structure and evolution of RIM-BP genes: identification of a novel family member.

RIMBP3 RIMBP3C RIMBP3B

8.13e-08571317855024
Pubmed

Kruppel-like factor 5 controls villus formation and initiation of cytodifferentiation in the embryonic intestinal epithelium.

LLGL2 FZD5 GLI1 GRHL3

1.00e-063771423266329
Pubmed

Key roles of retinoic acid receptors alpha and beta in the patterning of the caudal hindbrain, pharyngeal arches and otocyst in the mouse.

HOXB3 RARA RARB

1.77e-061271310529422
Pubmed

A census of human transcription factors: function, expression and evolution.

ALX3 ZNF384 MLXIPL HOXB3 ATF6 KMT2D RARA RARB GLI1 ZKSCAN2 GRHL3

2.22e-06908711119274049
Pubmed

Morphogenesis of the trachea and esophagus: current players and new roles for noggin and Bmps.

RARA RARB GLI1

2.30e-061371316916379
Pubmed

Integrative characterization of germ cell-specific genes from mouse spermatocyte UniGene library.

RIMBP3 RIMBP3C RIMBP3B

2.92e-061471317662146
Pubmed

Recurrent RARB Translocations in Acute Promyelocytic Leukemia Lacking RARA Translocation.

RARA RARB

4.11e-06271229921692
Pubmed

Retinoic acid receptors in normal growth and development.

RARA RARB

4.11e-0627121330302
Pubmed

Compartment-selective sensitivity of cardiovascular morphogenesis to combinations of retinoic acid receptor gene mutations.

RARA RARB

4.11e-0627129168777
Pubmed

Retinoic acid regulates gene expression of retinoic acid receptors alpha, beta and gamma in F9 mouse teratocarcinoma cells.

RARA RARB

4.11e-0627121334013
Pubmed

Biological functional annotation of retinoic acid alpha and beta in mouse liver based on genome-wide binding.

RARA RARB

4.11e-06271224833708
Pubmed

Purification and crystallization of the heterodimeric complex of RARbeta and RXRalpha ligand-binding domains in the active conformation.

RARA RARB

4.11e-06271215159591
Pubmed

[The significance of expression of isoforms RARa1 and RARa2 in response to medicinal therapy and in evaluation of total survival of patients with primarily detected multiple myeloma].

RARA RARB

4.11e-06271230601638
Pubmed

Reexpression of retinoic acid receptor (RAR) gamma or overexpression of RAR alpha or RAR beta in RAR gamma-null F9 cells reveals a partial functional redundancy between the three RAR types.

RARA RARB

4.11e-0627127644503
Pubmed

Association between nuclear expression of retinoic acid receptor alpha and beta and clinicopathological features and prognosis of advanced non-small cell lung cancer.

RARA RARB

4.11e-06271227306217
Pubmed

Anticancer effect of retinoic acid via AP-1 activity repression is mediated by retinoic acid receptor alpha and beta in gastric cancer cells.

RARA RARB

4.11e-06271212009305
Pubmed

Kif7 is required for the patterning and differentiation of the diaphragm in a model of syndromic congenital diaphragmatic hernia.

RARA RARB GLI1

1.06e-052171323650387
Pubmed

Retinoic acid regulates differentiation of the secondary heart field and TGFbeta-mediated outflow tract septation.

HOXB3 RARA RARB

1.06e-052171320230754
Pubmed

Function of the retinoic acid receptors (RARs) during development (II). Multiple abnormalities at various stages of organogenesis in RAR double mutants.

RARA RARB

1.23e-0537127607068
Pubmed

Function of the retinoic acid receptors (RARs) during development (I). Craniofacial and skeletal abnormalities in RAR double mutants.

RARA RARB

1.23e-0537127607067
Pubmed

Impaired distribution of retinoic acid receptors in the hindgut-tailgut region of murine embryos with anorectal malformations.

RARA RARB

1.23e-05371211172439
Pubmed

Cloning of several genes coding for retinoic acid nuclear receptors in the mouse embryonal carcinoma cell line PCC7-MZ1.

RARA RARB

1.23e-0537128383767
Pubmed

Retinoic acid receptor gamma: specific immunodetection and phosphorylation.

RARA RARB

1.23e-0537121655807
Pubmed

A redundant oncogenic potential of the retinoic receptor (RAR) alpha, beta and gamma isoforms in acute promyelocytic leukemia.

RARA RARB

1.23e-05371217252005
Pubmed

Retinoic acid down-regulation of fibronectin and retinoic acid receptor alpha proteins in NIH-3T3 cells. Blocks of this response by ras transformation.

RARA RARB

1.23e-0537128626453
Pubmed

Function of retinoic acid receptor gamma in the mouse.

RARA RARB

1.23e-0537128388780
Pubmed

Contribution of retinoic acid receptor beta isoforms to the formation of the conotruncal septum of the embryonic heart.

RARA RARB

1.23e-0537129659935
Pubmed

Retinoids and vertebrate development.

RARA RARB

1.23e-0537127910825
Pubmed

Tissue-specific expression of retinoic acid receptor isoform transcripts in the mouse embryo.

RARA RARB

1.23e-05371210842077
Pubmed

Inhibition of histone deacetylase activity by trichostatin A modulates gene expression during mouse embryogenesis without apparent toxicity.

RARA RARB

1.23e-05371211245412
Pubmed

mRNA expression pattern of retinoic acid and retinoid X nuclear receptor subtypes in human thyroid papillary carcinoma.

RARA RARB

1.23e-05371223969901
Pubmed

Altered expression of retinoic acid (RA) receptor mRNAs in the fetal mouse secondary palate by all-trans and 13-cis RAs: implications for RA-induced teratogenesis.

RARA RARB

1.23e-05371210100049
Pubmed

Both retinoic acid receptors alpha (RARalpha) and gamma (RARgamma) are able to initiate mouse upper-lip skin glandular metaplasia.

RARA RARB

1.23e-0537129699718
Pubmed

Mammalian hexokinase 1: evolutionary conservation and structure to function analysis.

RARA RARB

1.23e-0537121783373
Pubmed

Retinoic acid receptor-beta: immunodetection and phosphorylation on tyrosine residues.

RARA RARB

1.23e-0537121283441
Pubmed

Synergistic activation of RARβ and RARγ nuclear receptors restores cell specialization during stem cell differentiation by hijacking RARα-controlled programs.

RARA RARB

1.23e-05371236446525
Pubmed

Characterization of the interaction between retinoic acid receptor/retinoid X receptor (RAR/RXR) heterodimers and transcriptional coactivators through structural and fluorescence anisotropy studies.

RARA RARB

1.23e-05371215528208
Pubmed

Association of retinoic acid receptor genes with meningomyelocele.

RARA RARB

1.23e-05371221254357
Pubmed

Chromosomal assignment of retinoic acid receptor (RAR) genes in the human, mouse, and rat genomes.

RARA RARB

1.23e-0537121655630
Pubmed

Arg278, but not Lys229 or Lys236, plays an important role in the binding of retinoic acid by retinoic acid receptor gamma.

RARA RARB

1.23e-0537129852056
Pubmed

GRHL3/GET1 and trithorax group members collaborate to activate the epidermal progenitor differentiation program.

KMT2D GRHL3

1.23e-05371222829784
Pubmed

Differential expression of retinoic acid receptors in normal and malignant esophageal tissues.

RARA RARB

1.23e-05371215255287
Pubmed

Heterochromatic gene repression of the retinoic acid pathway in acute myeloid leukemia.

RARA RARB

1.23e-05371217244680
Pubmed

The molecular and genetic dissection of the retinoid signalling pathway.

RARA RARB

1.23e-0537128276261
Pubmed

Requirement of retinoic acid receptor isotypes alpha, beta, and gamma during the initial steps of neural differentiation of PCC7 cells.

RARA RARB

1.23e-05371215831518
Pubmed

Immunolocalization of retinoic acid receptors in rat, mouse and human ovary and uterus.

RARA RARB

1.23e-0537128136307
Pubmed

Genesis and prevention of spinal neural tube defects in the curly tail mutant mouse: involvement of retinoic acid and its nuclear receptors RAR-beta and RAR-gamma.

RARB GRHL3

1.23e-0537127720576
Pubmed

Genes involved in cell adhesion and signaling: a new repertoire of retinoic acid receptor target genes in mouse embryonic fibroblasts.

RARA RARB

1.23e-05371224357724
Pubmed

Retinoic acid and mouse skin morphogenesis. I. Expression pattern of retinoic acid receptor genes during hair vibrissa follicle, plantar, and nasal gland development.

RARA RARB

1.23e-0537128027572
Pubmed

Cloning of murine alpha and beta retinoic acid receptors and a novel receptor gamma predominantly expressed in skin.

RARA RARB

1.23e-0537122544807
Pubmed

[Genetic expression and morphogenesis of the skin in vertebrates].

RARA RARB

1.23e-0537128099268
Pubmed

Regulation of retinoic acid receptor alpha by protein kinase C in B16 mouse melanoma cells.

RARA RARB

1.23e-05371212000751
Pubmed

Specificity of retinoid receptor gene expression in mouse cervical epithelia.

RARA RARB

1.23e-0537128156902
Pubmed

Characterization of retinoic acid receptor-deficient keratinocytes.

RARA RARB

1.23e-05371210748128
Pubmed

Strain difference and mode of inheritance of the susceptibility to passive cutaneous anaphylaxis mediated by allogeneic IgE antibody in the mouse.

RARA RARB

1.23e-0537122737701
Pubmed

Immunohistochemical localization of the retinoic Acid receptors in human prostate.

RARA RARB

1.23e-05371212399530
Pubmed

Combinatorial knockout of RARα, RARβ, and RARγ completely abrogates transcriptional responses to retinoic acid in murine embryonic stem cells.

RARA RARB

1.23e-05371229848550
Pubmed

HACE1: A novel repressor of RAR transcriptional activity.

RARA RARB

2.46e-05471219350571
Pubmed

Association of peroxisome proliferator-activated receptors/retinoic acid receptors with renal diseases.

RARA RARB

2.46e-05471224050824
Pubmed

Roles of retinoic acid receptors and of Hox genes in the patterning of the teeth and of the jaw skeleton.

RARA RARB

2.46e-0547127626396
Pubmed

Synergistic activation of retinoic acid (RA)-responsive genes and induction of embryonal carcinoma cell differentiation by an RA receptor alpha (RAR alpha)-, RAR beta-, or RAR gamma-selective ligand in combination with a retinoid X receptor-specific ligand.

RARA RARB

2.46e-0547128524212
Pubmed

Immunolocalization of enzymes, binding proteins, and receptors sufficient for retinoic acid synthesis and signaling during the hair cycle.

RARA RARB

2.46e-05471217363914
Pubmed

Nuclear GRP75 binds retinoic acid receptors to promote neuronal differentiation of neuroblastoma.

RARA RARB

2.46e-05471222022577
Pubmed

Biosynthesis and function of all-trans- and 9-cis-retinoic acid in parathyroid cells.

RARA RARB

2.46e-0547129005841
Pubmed

Specific and redundant functions of retinoid X Receptor/Retinoic acid receptor heterodimers in differentiation, proliferation, and apoptosis of F9 embryonal carcinoma cells.

RARA RARB

2.46e-0547129348290
Pubmed

Physiological and retinoid-induced proliferations of epidermis basal keratinocytes are differently controlled.

RARA RARB

2.46e-05471212093741
Pubmed

The retinoid receptors.

RARA RARB

2.46e-0547127967725
Pubmed

Identification of a retinoid receptor response element in the human aldehyde dehydrogenase-2 promoter.

RARA RARB

2.46e-05471214691372
Pubmed

Retinoic acid regulates the human methionine sulfoxide reductase A (MSRA) gene via two distinct promoters.

RARA RARB

2.46e-05471218845237
Pubmed

The retinoic acid receptors RARalpha and RARgamma are required for inner ear development.

RARA RARB

2.46e-05471212464434
Pubmed

Limited specificity and large overlap of the functions of the mouse RAR gamma 1 and RAR gamma 2 isoforms.

RARA RARB

2.46e-0547129376317
Pubmed

Poly (ADP-ribose) glycohydrolase regulates retinoic acid receptor-mediated gene expression.

RARA RARB

2.46e-05471223102699
Pubmed

Differential expression of genes encoding alpha, beta and gamma retinoic acid receptors and CRABP in the developing limbs of the mouse.

RARA RARB

2.46e-0547122556642
Pubmed

Retinoic acid signalling in the development of branchial arches.

RARA RARB

2.46e-05471215380252
Pubmed

Dimerization with retinoid X receptors and phosphorylation modulate the retinoic acid-induced degradation of retinoic acid receptors alpha and gamma through the ubiquitin-proteasome pathway.

RARA RARB

2.46e-05471210869350
Pubmed

Identification of novel candidate genes in heterotaxy syndrome patients with congenital heart diseases by whole exome sequencing.

KMT2D GLI1

2.46e-05471232738303
Pubmed

22q11 Gene dosage establishes an adaptive range for sonic hedgehog and retinoic acid signaling during early development.

RARA RARB GLI1

2.87e-052971323077214
Pubmed

Retinoic acid signaling regulates murine bronchial tubule formation.

RARA RARB

4.09e-05571212834868
Pubmed

An essential set of basic DNA response elements is required for receptor-dependent transcription of the lecithin:retinol acyltransferase (Lrat) gene.

RARA RARB

4.09e-05571219665987
Pubmed

Genetic evidence that the retinoid signal is transduced by heterodimeric RXR/RAR functional units during mouse development.

RARA RARB

4.09e-0557129053308
Pubmed

Changes of the expression and distribution of retinoic acid receptors during neurogenesis in mouse embryos.

RARA RARB

4.09e-0557128174226
Pubmed

Distal ureter morphogenesis depends on epithelial cell remodeling mediated by vitamin A and Ret.

RARA RARB

4.09e-05571212195422
Pubmed

Retinoic acid signaling is necessary for the development of the organ of Corti.

RARA RARB

4.09e-05571210452855
Pubmed

Epithelial retinoic acid receptor β regulates serum amyloid A expression and vitamin A-dependent intestinal immunity.

RARA RARB

4.09e-05571231097581
Pubmed

Regulation of the Oct-4 gene by nuclear receptors.

RARA RARB

4.09e-0557128152920
Pubmed

Retinoic acid receptor beta 2 mRNA is elevated by retinoic acid in vivo in susceptible regions of mid-gestation mouse embryos.

RARA RARB

4.09e-0557121334737
Pubmed

Vitamin A controls epithelial/mesenchymal interactions through Ret expression.

RARA RARB

4.09e-05571211138002
Pubmed

High postnatal lethality and testis degeneration in retinoic acid receptor alpha mutant mice.

RARA RARB

4.09e-0557128394014
Pubmed

Initiation of retinoid signaling in primitive streak mouse embryos: spatiotemporal expression patterns of receptors and metabolic enzymes for ligand synthesis.

RARA RARB

4.09e-0557129097025
Pubmed

Retinal dysplasia and degeneration in RARbeta2/RARgamma2 compound mutant mice.

RARA RARB

4.09e-0557128681798
Pubmed

Retinoic acid enhances Foxp3 induction indirectly by relieving inhibition from CD4+CD44hi Cells.

RARA RARB

4.09e-05571219006694
Pubmed

ZNF423 is critically required for retinoic acid-induced differentiation and is a marker of neuroblastoma outcome.

RARA RARB

4.09e-05571219345331
Pubmed

Regulation of prefrontal patterning and connectivity by retinoic acid.

CHL1 RARA RARB

4.66e-053471334599305
Pubmed

Systematic immunolocalization of retinoid receptors in developing and adult mouse eyes.

RARA RARB

6.13e-05671211328745
Pubmed

The isolation and characterization of purified heterocomplexes of recombinant retinoic acid receptor and retinoid X receptor ligand binding domains.

RARA RARB

6.13e-0567129153406
Pubmed

Dysregulated endocardial TGFβ signaling and mesenchymal transformation result in heart outflow tract septation failure.

RARA RARB

6.13e-05671226522286
Pubmed

Roles of retinoic acid receptors in early embryonic morphogenesis and hindbrain patterning.

RARA RARB

6.13e-05671211493525
Pubmed

Spatial distributions of retinoic acid receptor gene transcripts in the prenatal mouse inner ear.

RARA RARB

6.13e-0567129548551
Pubmed

Functional specificity of the two retinoic acid receptor RAR and RXR families in myogenesis.

RARA RARB

6.13e-0567129464546
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

CHL1 HOXB3 LLGL2 MFHAS1 SYNE2 ESRP1

6.55e-07193716f42a0f02ed00fe1bb833ff0a0640d9131bca89bd
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

CHL1 HOXB3 LLGL2 MFHAS1 SYNE2 ESRP1

6.55e-0719371642df7ed37d11fb542b4d1d714b6f87ae8e1396a6
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

CHL1 HOXB3 LLGL2 MFHAS1 SYNE2 ESRP1

6.75e-07194716e577d9e88390b36b5a09b97fe1026089892275a3
ToppCellPBMC-Mild-Lymphocyte-T/NK|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PDE3B LLGL2 SYNE2 DENND2D TESPA1 CD96

7.83e-07199716dfdf551a292e33e3ee356629fa48a0a2f009624d
ToppCellPBMC-Mild-Lymphocyte-T/NK|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

PDE3B LLGL2 SYNE2 DENND2D TESPA1 CD96

7.83e-07199716ec7a1b0b71175b3a4015522bf88784eb176d59e3
ToppCellCOVID-19_Mild-Lymphoid_T/NK|COVID-19_Mild / Disease group, lineage and cell class

PDE3B LLGL2 SYNE2 DENND2D TESPA1 CD96

8.06e-07200716e69416952039ca076e9b71187d8783fe567ee873
ToppCellLPS_only-Endothelial|LPS_only / Treatment groups by lineage, cell group, cell type

VWF CASKIN2 SYNE2 SLC25A47 N4BP3 PREX2

8.06e-0720071681e76508c9050d533853d5fd2f3097b27613d836
ToppCellCOVID-19-COVID-19_Mild-Lymphocyte-T/NK|COVID-19_Mild / Disease, condition lineage and cell class

PDE3B LLGL2 SYNE2 DENND2D TESPA1 CD96

8.06e-072007166d9796153d038329a820949c0b88fd01265a1227
ToppCellCOVID-19-COVID-19_Mild-Lymphocyte-T/NK-CD4+_T_activated|COVID-19_Mild / Disease, condition lineage and cell class

MFHAS1 SYNE2 HELZ2 ABCF2 TESPA1 CD96

8.06e-07200716d9e8a0d047d4403fb7265fde7448e23a7780785c
ToppCellLPS_IL1RA_TNF-Endothelial-Endothelial-Activated_Gen_Cap|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

VWF CASKIN2 SYNE2 SLC25A47 N4BP3 PREX2

8.06e-072007163585484c7e24e941708bee471ca607d8ccee74e6
ToppCellLPS_only-Endothelial-Endothelial|LPS_only / Treatment groups by lineage, cell group, cell type

VWF CASKIN2 SYNE2 SLC25A47 N4BP3 PREX2

8.06e-072007164bb609a284d4e6066f17470a1736076aa4a1f84c
ToppCellMild/Remission-B_naive-5|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)

ALX3 MLXIPL RIMBP3C MADCAM1 CD96

3.93e-061487158b60f9843505660b3c9d5c7792976f902be4b94c
ToppCell10x5'-bone_marrow-Lymphocytic_T_CD8-Trm_gut_CD8|bone_marrow / Manually curated celltypes from each tissue

PDE3B GLI1 TNFRSF19 NANOS1 CD96

4.78e-0615471593145a1bc5712ae664690b03a9e00ce1f92cfc7e
ToppCellmild_COVID-19_(asymptomatic)-CD8+_T_naive|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)

PDE3B PAPPA PLSCR2 NANOS1 CD96

4.93e-06155715e2c901d5c9e42d25d7702e5e8fc19b06f7c817be
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD8_c01-LEF1|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

TTLL12 PDE3B SYNE2 TESPA1 CD96

5.93e-061617155fba13f0aa5002f7eefe219e2c6a07e163f1a50d
ToppCellsystemic_lupus_erythematosus-flare-Lymphocytic_T-CytoT_GZMK+-male|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

GREB1L TICRR SYNE2 PAPPA CD96

6.11e-0616271519395bdb282b4a2d88cd33191af12c24a88c3d16
ToppCellT_cells-Tph_and_Tfh|World / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues

PDE3B SYNE2 KSR2 TESPA1 CD96

6.11e-06162715146058f2d60846376078916055d08f68562e3a7c
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-1M-Stem_cells-ectodermal/neuroectodermal-like_cells|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.

SPRR3 ESRP1 DENND2D GRHL3 KDF1

6.88e-06166715d7e49416426a62801ea1062d7aaf55ea622ae118
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

PDE3B MFHAS1 SYNE2 TESPA1 CD96

1.02e-05180715d9dae9db8e17f6990032ee6cfa8393fae4768ca5
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

GREB1L HOXB3 PDE3B KSR2 PAPPA

1.10e-05183715b5ede5a0048c585b73c00e88aeddbcaf669347b1
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c02-GPR183|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

PDE3B AEBP1 SYNE2 TESPA1 CD96

1.16e-05185715847257d232b9993cad50c814fd4ffeef52385295
ToppCellfacs-Trachea-nan-18m-Epithelial|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CHL1 CLCA2 ESRP1 GRHL3 KDF1

1.23e-051877158882a638af7165b2910ba8e932d55475d7bfb003
ToppCellSevere-Myeloid-Macrophages-|Severe / Condition, Lineage, Cell class and cell subclass

PDE3B IGHG4 SYNE2 TESPA1 CD96

1.29e-05189715769b52073a0f0543a72e9f32772321194b70cb2f
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

AEBP1 GLI1 ANGPT4 PAPPA TNFRSF19

1.29e-0518971545e588b2a4ad9e3ff74e22d9d627ed3571f3b8b8
ToppCellTCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Squamous_Cell_Carcinoma|TCGA-Lung / Sample_Type by Project: Shred V9

TTLL12 TICRR CLCA2 SPRR3 GRHL3

1.29e-05189715aa4f7d7a5196e5ae481ebc2549de8e3f0ef6e6be
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CHL1 HOXB3 LLGL2 MFHAS1 ESRP1

1.32e-051907153fc9e18c7441c0ae8cda65753cc42d0520f4e116
ToppCellfacs-Trachea-18m-Epithelial-airway_epithelial|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CHL1 CLCA2 ESRP1 GRHL3 KDF1

1.36e-05191715cd4e2e883c4955fb2d875e41bb6ebc680994dc8c
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CHL1 HOXB3 LLGL2 MFHAS1 ESRP1

1.36e-051917155a67ff17fb4b9eff641176dff07830c9cd73754e
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CHL1 HOXB3 LLGL2 MFHAS1 ESRP1

1.36e-0519171555ab2854a02cdcfc395e49870ccb7290b5e5471d
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD8_c01-LEF1|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

PDE3B CEP95 SYNE2 TESPA1 CD96

1.36e-05191715696921a4f160b6b55698652488ed781e855e5e51
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

PDE3B MFHAS1 SYNE2 TESPA1 CD96

1.39e-051927157ab626a516b07d899175ff12f1c8257688324e4b
ToppCellCOVID-19_Severe-CD4+_Tcm|World / disease group, cell group and cell class

PDE3B MFHAS1 SYNE2 TESPA1 CD96

1.39e-051927153352f13a6e706991dcf3ec173587bb6aba36a385
ToppCellfacs-Trachea-18m-Epithelial|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CHL1 CLCA2 ESRP1 GRHL3 KDF1

1.39e-05192715c5823c5d4c58a4e9121a4b7d7256481d6d9e9b7f
ToppCellCOVID-19_Moderate-CD4+_T_activated|World / disease group, cell group and cell class

PDE3B SYNE2 HELZ2 TESPA1 CD96

1.43e-05193715c2a2a2c14a7085690262db5c2a70e38db67dee18
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

AEBP1 UGT2A3 SYNE2 KLRG2 TNFRSF19

1.43e-05193715ffa1932da2979d7b63dbac32eb5788346a3f5b2a
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CHL1 AEBP1 UGT2A3 SYNE2 KLRG2

1.43e-051937150f2167eef8203a5659c8c72e4e77646003d64797
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CHL1 HOXB3 LLGL2 MFHAS1 ESRP1

1.43e-05193715263d185af6ed80e639f864e4966268e0862c61dc
ToppCellCOVID-19_Severe-Lymphoid_T/NK-CD4+_T_activated|COVID-19_Severe / Disease group, lineage and cell class

PDE3B SYNE2 DENND2D TESPA1 CD96

1.43e-05193715beb862d38b88572836b0a797c8efef7a2492e0b9
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CHL1 HOXB3 LLGL2 MFHAS1 ESRP1

1.43e-0519371580e058c224749b5fe0ba3e944b48317c2371cb63
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CHL1 HOXB3 LLGL2 MFHAS1 ESRP1

1.43e-05193715b991fbbb4618401624f0b3045f0e81a606d3a763
ToppCellPBMC-Severe-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

PDE3B SYNE2 DENND2D TESPA1 CD96

1.43e-05193715f8af695457d2a0a911a5ac491742465864ebda37
ToppCellCOVID-19_Severe-CD4+_Tcm|COVID-19_Severe / disease group, cell group and cell class

PDE3B MFHAS1 SYNE2 TESPA1 CD96

1.43e-0519371545fe14c10b71459047608c8931d83c9c533f97f9
ToppCellPBMC-Severe-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

PDE3B SYNE2 DENND2D TESPA1 CD96

1.43e-05193715089aece40130034a89a5213be778f10b0787eeba
ToppCellPBMC-Mild-Lymphocyte-T/NK-CD4+_T-CD4+_Tcm-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PDE3B MFHAS1 SYNE2 TESPA1 CD96

1.46e-05194715929b97eb0a4a88cd566f832d4959b8b8a34c46b4
ToppCellPBMC-Mild-Lymphocyte-T/NK-CD4+_T-CD4+_Tcm|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PDE3B MFHAS1 SYNE2 TESPA1 CD96

1.46e-051947154bcbea5dc0c91c51fbb6b0f7de1e47010c62812a
ToppCell(1)_T_cells|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)

PDE3B SYNE2 DENND2D TESPA1 CD96

1.46e-05194715f9639f57976bbfff1d6140a542cd50a8b1ded2dc
ToppCellCOVID-19_Mild-Lymphoid_T/NK-CD4+_Tcm|COVID-19_Mild / Disease group, lineage and cell class

PDE3B MFHAS1 SYNE2 TESPA1 CD96

1.46e-051947150aad8c7f356d54346af764e0cc4edce89c6daabb
ToppCellPBMC-Mild-Lymphocyte-T/NK-CD4+_T-CD4+_Tcm|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

PDE3B MFHAS1 SYNE2 TESPA1 CD96

1.46e-051947158c3c04770913724b4e93941b547402052ae352c2
ToppCellPBMC-Mild-Lymphocyte-T/NK-CD4+_T-CD4+_Tcm-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

PDE3B MFHAS1 SYNE2 TESPA1 CD96

1.46e-05194715884b5c98a1fdc651d7f4a0fad2a5965859207abc
ToppCellcritical-Lymphoid-Treg|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

PDE3B MFHAS1 DENND2D TESPA1 CD96

1.46e-05194715deaae292972371b6afae58a023fe2fc05b351bda
ToppCellCOVID-19_Severe-Lymphoid_T/NK-CD4+_Tcm|COVID-19_Severe / Disease group, lineage and cell class

PDE3B MFHAS1 SYNE2 TESPA1 CD96

1.50e-05195715658751e384de50cdcb907d3740fb1a74004a517b
ToppCellfacs-Tongue|facs / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CHL1 ESRP1 KLRG2 GRHL3 KDF1

1.50e-0519571577128895db9221a64a171082d468ebcd6380c936
ToppCellPBMC-Severe-Lymphocyte-T/NK-CD4+_T-CD4+_Tcm-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

PDE3B MFHAS1 SYNE2 TESPA1 CD96

1.50e-05195715e3e5c784e7b494434fb4f6f27e0af22b167842ef
ToppCellsystemic_lupus_erythematosus-flare-Lymphocytic_T|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

PDE3B SYNE2 DENND2D TESPA1 CD96

1.50e-0519571553528e5788083bce5a8d4611ab3808878e6a9cd3
ToppCellCOVID_non-vent-Lymphocytic-T_cell-CD4+_Memory_T_cell|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

PDE3B MFHAS1 SYNE2 TESPA1 CD96

1.50e-0519571522191d361af136942508f1553ff41a626ed982ad
ToppCellPBMC-Severe-Lymphocyte-T/NK-CD4+_T-CD4+_Tcm|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

PDE3B MFHAS1 SYNE2 TESPA1 CD96

1.50e-05195715d6b8bc4204476220a64afe17e3b6b2ed59853284
ToppCellPBMC-Severe-Lymphocyte-T/NK-CD4+_T-CD4+_Tcm|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PDE3B MFHAS1 SYNE2 TESPA1 CD96

1.54e-05196715459408882babf1fb56b37dc52ec119ac0b0153a7
ToppCellPBMC-Severe-Lymphocyte-T/NK-CD4+_T-CD4+_Tcm-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PDE3B MFHAS1 SYNE2 TESPA1 CD96

1.54e-05196715a1a1e4e4404a0c590edd07dfc9e7e1b6f720fb0f
ToppCellSepsis-URO-Lymphocyte-T/NK-Treg|URO / Disease, condition lineage and cell class

MFHAS1 SYNE2 N4BP3 NANOS1 TESPA1

1.54e-051967158812d7365fb2b33feff93782d60776e932499a43
ToppCell10x_3'_v3-lymph_node_(10x_3'_v3)-lymphocytic-T_lymphocytic|lymph_node_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

PDE3B SYNE2 DENND2D TESPA1 CD96

1.58e-05197715b044833de12f2b9eb702155563cd8932bc16e0ef
ToppCell10x5'-Liver-Lymphocytic_T_CD4|Liver / Manually curated celltypes from each tissue

PDE3B MFHAS1 SYNE2 TESPA1 CD96

1.58e-051977154891111894b741555f549deec6af8006376d9358
ToppCellTracheal-10x3prime_v2-Immune_Lymphocytic-T-T_CD4-CD4_naive/CM|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

GREB1L PDE3B DENND2D TESPA1 CD96

1.58e-051977151c78bd52b94a9466459a645ac9bd14bac22c54bd
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_T|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

PDE3B SYNE2 DENND2D TESPA1 CD96

1.58e-0519771559b1fb93a39dcf8c994d2b7dc2906dae74c57527
ToppCell10x_3'_v3-thymus_(10x_3'_v3)-lymphocytic-T_lymphocytic-CD4-positive_helper_T_cell|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

PDE3B SYNE2 DENND2D TESPA1 CD96

1.61e-05198715c4d8d133e571ad3a7c5de93aa7befb67cb7a003d
ToppCellCOVID_vent-Lymphocytic-T_cell-CD4+_Memory_T_cell|COVID_vent / Disease condition, Lineage, Cell class and subclass

PDE3B MFHAS1 SYNE2 TESPA1 CD96

1.61e-0519871558f208b76cb0adcecdf632d92f92833a06f9bf71
ToppCell10x_3'_v3-thymus_(10x_3'_v3)-lymphocytic-T_lymphocytic|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

PDE3B SYNE2 DENND2D TESPA1 CD96

1.61e-05198715db107a5511571384f26e26c6301aef9a9f2423c4
ToppCellsevere_COVID-19-NK|World / disease group, cell group and cell class (v2)

LLGL2 SYNE2 DENND2D N4BP3 CD96

1.61e-0519871536b1370ef68c4bbe0268933a6ef5e6022d992bdf
ToppCell10x5'-lymph-node_spleen-Lymphocytic_T_CD4|lymph-node_spleen / Manually curated celltypes from each tissue

PDE3B SYNE2 DENND2D TESPA1 CD96

1.61e-051987152cbafcb03df3c9aca68371df500d18ab8dcc416c
ToppCellmild-CD4+_Tcm|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

PDE3B MFHAS1 SYNE2 TESPA1 CD96

1.65e-0519971506c8a0e39f7a33736548f04a5e2263334c8541cf
ToppCelldistal-3-mesenchymal-Myofibroblast|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

HOXB3 AEBP1 GLI1 PAPPA TNFRSF19

1.65e-051997151f20addc0d138fec02ed6ca4c518169c568de263
ToppCellCOVID-19_Moderate|World / disease group, cell group and cell class

PDE3B IGHG4 SYNE2 HELZ2 CD96

1.65e-05199715952fac67588ad5676f5939e3c7f8bac803c27064
ToppCellmLN-T_cell|mLN / Region, Cell class and subclass

PDE3B SYNE2 DENND2D TESPA1 CD96

1.65e-05199715caa37ec509b54e842564d754f100ab1b2a77a7c1
ToppCellmLN-(1)_T_cell|mLN / shred on region, Cell_type, and subtype

PDE3B SYNE2 DENND2D TESPA1 CD96

1.65e-051997154bf2641409c543c2167bff71efa95b00dd7bfe19
ToppCellLPS_IL1RA-Endothelial-Endothelial|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

PDE3B VWF CASKIN2 SYNE2 N4BP3

1.69e-0520071572ea9882a8ed26fa1534aeb6ba0d1897dccc20c5
ToppCelldistal-mesenchymal-Myofibroblast-3|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

HOXB3 AEBP1 GLI1 PAPPA TNFRSF19

1.69e-05200715069c8949b33ecfdb6da32992002d4060ff6082bc
ToppCellPBMC-Control-Lymphocyte-T/NK|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

LLGL2 SYNE2 DENND2D TESPA1 CD96

1.69e-052007151dd0141e87902d96a76edcd966988f61a532c808
ToppCellPBMC-Control-Lymphocyte-T/NK|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

LLGL2 SYNE2 DENND2D TESPA1 CD96

1.69e-052007157f79ab7737188b1f7fb5c2a0b1d6d2a565d36385
ToppCellLPS_only-Endothelial-Endothelial-Gen_Cap|LPS_only / Treatment groups by lineage, cell group, cell type

PDE3B VWF CASKIN2 N4BP3 PREX2

1.69e-05200715eb94a5111ef0e903ee5be9f7efe571b4e6d5fce1
ToppCellLPS_IL1RA-Endothelial|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

PDE3B VWF CASKIN2 SYNE2 N4BP3

1.69e-052007155c092b2ecc081b5d04476c56333c338cd89ab984
ToppCellCOVID-19-COVID-19_Severe-Lymphocyte-T/NK-CD4+_Tcm|COVID-19_Severe / Disease, condition lineage and cell class

PDE3B MFHAS1 SYNE2 TESPA1 CD96

1.69e-05200715b0073497dfd04d900d60e3ec7b8f2e8ae3ba02d1
ToppCellLPS_IL1RA_TNF-Endothelial-Endothelial-Activated_Alv_Cap|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

CASKIN2 SYNE2 HELZ2 SLC25A47 N4BP3

1.69e-0520071589821a264e872ed53e08e9d3609d5cc5c314503e
ToppCellCOVID-19-COVID-19_Mild-Lymphocyte-T/NK-CD4+_Tcm|COVID-19_Mild / Disease, condition lineage and cell class

PDE3B MFHAS1 SYNE2 TESPA1 CD96

1.69e-052007159c7e9ba7a1a6bb0e97b7b5603940da09f06a567f
ToppCellLPS_anti-TNF-Endothelial-Endothelial-Activated_Gen_Cap|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

PDE3B VWF CASKIN2 N4BP3 PREX2

1.69e-05200715f15fffefe372005c33e31845982e2d2714ac26af
ToppCelldistal-mesenchymal-Myofibroblast|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

HOXB3 AEBP1 GLI1 PAPPA TNFRSF19

1.69e-0520071561854a459385cd9295be37157a8f81a2c227dff3
ToppCellControl-Lymphoid_T/NK|Control / Disease group, lineage and cell class

LLGL2 SYNE2 DENND2D TESPA1 CD96

1.69e-05200715b5d5eead192a22c6b5ea699fe36873809fe6e3e2
ToppCellmild-CD4+_Tcm|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

PDE3B MFHAS1 SYNE2 TESPA1 CD96

1.69e-05200715dc10628886d1d3ff9dce25ade10920e69a6ab8c2
ToppCellControl-Control-Lymphocyte-T/NK|Control / Disease, condition lineage and cell class

LLGL2 SYNE2 DENND2D TESPA1 CD96

1.69e-052007156a399d9fa005547e5fadd3c0dafd7e4381732460
ToppCellLPS_IL1RA_TNF-Endothelial-Endothelial-Gen_Cap|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

PDE3B VWF CASKIN2 N4BP3 PREX2

1.69e-05200715b2d4e6f3e8e4da62e6b02758ab2ed8f505269f9a
ToppCellCOVID-19-COVID-19_Severe-Lymphocyte-T/NK-CD4+_T_activated|COVID-19_Severe / Disease, condition lineage and cell class

PDE3B SYNE2 DENND2D TESPA1 CD96

1.69e-05200715deeed668b129e66156b5f6abe1a07a9bf842a14d
ToppCellLPS_anti-TNF-Endothelial-Endothelial-Artery|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

PDE3B VWF SYNE2 TNFRSF19 PREX2

1.69e-05200715b1ff8d61b567f85006d6d20093f9c803b6d34674
ToppCellsevere-CD4+_Tcm|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

PDE3B MFHAS1 SYNE2 TESPA1 CD96

1.69e-05200715e83558090a079dd9e40e0d3b5d9917fbd2695ec4
ToppCellControl-Epithelial_alveolar-AT_2-AT1-AT2|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ESRP1 WIPF3 GRHL3 SBK2

3.69e-05117714c6fc72608d56a389bcd87b5dc98a11e39b79bcb2
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Inner_Medullary_Collecting_Duct_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

GREB1L KSR2 ESRP1 GRHL3

6.82e-0513771448c21e6938a46e3cd74ac10b8ace0a4751741af7
ToppCell10x3'2.3-week_12-13-Hematopoietic-HSC/MPP_and_pro-MPP_myeloid|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

MLXIPL GLI1 KLRG2 PREX2

7.42e-05140714eb1d22f5f5dbf60b6485464baec4be9b3060f65c
ToppCellMild/Remission-B_naive-5|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

ALX3 MLXIPL RIMBP3C MADCAM1

7.84e-05142714fc5fc2d2b4b976358b8ce762c1f440b20db84103
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-CD4/CD8-Stress_sig-Z|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

LLGL2 SYNE2 TESPA1 CD96

8.06e-05143714eb11ff288cb91210383b288aa57715ebd59a52c3
ToppCellsaliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c06-TNF|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

GLI1 ZKSCAN2 TESPA1 CD96

9.45e-051497143378d0fe79de6d7879fd48717ded5027593c785f
ToppCellPBMC-Severe-Lymphocyte-T/NK-Other_T-dn_T|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SYNE2 DENND2D TESPA1 CD96

1.02e-04152714405d19b290232bb3e564d61c0cff0cfdd247bdff
ToppCellPBMC-Severe-Lymphocyte-T/NK-Other_T-dn_T-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SYNE2 DENND2D TESPA1 CD96

1.02e-0415271406fa7d8acc8f56de00af9bee17884595b300410e
ToppCellmild_COVID-19_(asymptomatic)-CD8+_T_naive|World / disease group, cell group and cell class (v2)

PDE3B PAPPA PLSCR2 NANOS1

1.02e-04152714f944743f40ff6ed3a7a096dd53e12d3526c67c4d
DrugRo 8-8717

RARA RARB

9.05e-062692CID006438148
DrugTamibarotene

RARA RARB

9.05e-062692DB04942
DrugVinpocetine [42971-09-5]; Up 200; 11.4uM; MCF7; HT_HG-U133A

CHL1 PDE3B FZD5 UGT2A3 ABCF2 PREX2

2.96e-051976963174_UP
DrugAdamantamine fumarate [80789-67-9]; Up 200; 9.6uM; PC3; HT_HG-U133A

HOXB3 RARA RARB EFS ANGPT4 PREX2

2.96e-051976964222_UP
DrugPropranolol hydrochloride [318-98-9]; Up 200; 13.6uM; PC3; HT_HG-U133A

CHL1 GHRHR RARA PAPPA PREX2 ARHGAP33

2.96e-051976966759_UP
DrugEsculin Hydrate [531-75-9]; Up 200; 11.8uM; MCF7; HT_HG-U133A

GHRHR MLXIPL PDE3B PLCB3 MADCAM1 ARHGAP33

2.96e-051976965411_UP
DrugIodixanol [92339-11-2]; Up 200; 2.6uM; HL60; HT_HG-U133A

HOXB3 KMT2D EFS CASKIN2 PAPPA ABCF2

3.05e-051986963023_UP
Drugflufenamic acid; Down 200; 10uM; MCF7; HG-U133A

GREB1L ALX3 MLXIPL ATF6 RARA ABCF2

3.22e-05200696316_DN
Diseasevery low density lipoprotein cholesterol measurement, cholesterol:total lipids ratio

MLXIPL MFHAS1 SYNE2 HELZ2 PLCB3 KDF1

1.06e-05222666EFO_0008317, EFO_0020943
DiseaseCrohn's disease (implicated_via_orthology)

EFS MADCAM1

1.48e-053662DOID:8778 (implicated_via_orthology)
Diseasevery low density lipoprotein cholesterol measurement, cholesteryl esters:total lipids ratio

MLXIPL MFHAS1 SYNE2 HELZ2 PLCB3 KDF1

2.81e-05264666EFO_0008317, EFO_0020944
DiseaseNeuralgia-Neuritis, Sciatic Nerve

RARA RARB

2.95e-054662C0751924
DiseaseSciatic Nerve Palsy

RARA RARB

2.95e-054662C0751925
DiseaseLesion of Sciatic Nerve

RARA RARB

2.95e-054662C0154748
DiseaseSciatic Neuritis

RARA RARB

2.95e-054662C0242013
DiseaseSciatic Neuropathy

RARA RARB

2.95e-054662C0149940
DiseasePhyllodes Tumor

KMT2D RARA

4.91e-055662C0010701
DiseaseMalignant Cystosarcoma Phyllodes

KMT2D RARA

4.91e-055662C0600066
Diseaseforced expiratory volume

HOXB3 LLGL2 RARB MFHAS1 CEP95 ZKSCAN2 NPC2 AK9 DENND2D

6.33e-05789669EFO_0004314
Diseaselow density lipoprotein cholesterol measurement, free cholesterol:total lipids ratio

MLXIPL MFHAS1 SYNE2 PLCB3 KDF1

8.69e-05200665EFO_0004611, EFO_0020945
DiseaseMalignant neoplasm of breast

KMT2D LLGL2 VWF RARA RARB CLCA2 WDR88 GLI1 SYNE2 NUDT17

1.30e-0410746610C0006142
Diseasetriglyceride measurement, very low density lipoprotein cholesterol measurement

MLXIPL LLGL2 SYNE2 PLCB3 KDF1

1.48e-04224665EFO_0004530, EFO_0008317
Diseasetriglycerides:total lipids ratio, very low density lipoprotein cholesterol measurement

MLXIPL MFHAS1 HELZ2 PLCB3 KDF1

1.51e-04225665EFO_0008317, EFO_0020947
Diseasetriglycerides:total lipids ratio, low density lipoprotein cholesterol measurement

MLXIPL MFHAS1 SYNE2 PLCB3

3.62e-04150664EFO_0004611, EFO_0020947
Diseasevery low density lipoprotein cholesterol measurement, phospholipids:total lipids ratio

MLXIPL MFHAS1 SYNE2 HELZ2 PLCB3

4.93e-04291665EFO_0008317, EFO_0020946
DiseaseProteinuria

VWF RARB

5.08e-0415662HP_0000093
Diseasetriglyceride measurement, low density lipoprotein cholesterol measurement

MLXIPL SYNE2 PLCB3 KDF1

5.31e-04166664EFO_0004530, EFO_0004611
Diseasefrontal pole volume measurement

RARB NANOS1

7.37e-0418662EFO_0010304
Diseasecarotid artery disease (is_marker_for)

VWF PAPPA

8.22e-0419662DOID:3407 (is_marker_for)
DiseaseLiver carcinoma

TICRR MLXIPL SCAP RARA GLI1 SLC25A47

9.49e-04507666C2239176
Diseasetriglycerides:total lipids ratio, high density lipoprotein cholesterol measurement

MLXIPL SYNE2 PLCB3 KDF1

1.19e-03206664EFO_0004612, EFO_0020947
Diseasechylomicron measurement, very low density lipoprotein cholesterol measurement, lipid measurement

MLXIPL PLCB3 KDF1

1.28e-0395663EFO_0004529, EFO_0008317, EFO_0008596
Diseasechylomicron measurement, triglyceride measurement, very low density lipoprotein cholesterol measurement

MLXIPL PLCB3 KDF1

1.32e-0396663EFO_0004530, EFO_0008317, EFO_0008596
Diseaseaspartate measurement

TTLL12 AGA

1.32e-0324662EFO_0010462
Diseasedigestive system infectious disorder

MFHAS1 CD96

1.55e-0326662MONDO_0043424
Diseaseunipolar depression, depressive symptom measurement

KSR2 ZKSCAN2

1.55e-0326662EFO_0003761, EFO_0007006
Diseasecholesteryl esters:total lipids ratio, intermediate density lipoprotein measurement

MLXIPL SYNE2 PLCB3

1.61e-03103663EFO_0008595, EFO_0020944
Diseasebreast milk measurement

RARB AGA PREX2

1.75e-03106663EFO_0009092
Diseasechylomicron measurement, very low density lipoprotein cholesterol measurement

MLXIPL PLCB3 KDF1

1.75e-03106663EFO_0008317, EFO_0008596
Diseaselung small cell carcinoma (is_implicated_in)

KMT2D RARB

1.79e-0328662DOID:5409 (is_implicated_in)
Diseasechylomicron measurement, very low density lipoprotein cholesterol measurement, phospholipid measurement

MLXIPL PLCB3 KDF1

1.89e-03109663EFO_0004639, EFO_0008317, EFO_0008596
Diseasecholesteryl ester measurement, chylomicron measurement, very low density lipoprotein cholesterol measurement

MLXIPL PLCB3 KDF1

1.94e-03110663EFO_0008317, EFO_0008596, EFO_0010351
Diseasefree cholesterol measurement, chylomicron measurement, very low density lipoprotein cholesterol measurement

MLXIPL PLCB3 KDF1

1.94e-03110663EFO_0008317, EFO_0008591, EFO_0008596
Diseasechylomicron measurement, total cholesterol measurement, very low density lipoprotein cholesterol measurement

MLXIPL PLCB3 KDF1

1.94e-03110663EFO_0004574, EFO_0008317, EFO_0008596

Protein segments in the cluster

PeptideGeneStartEntry
LSFYFPPCGKIPPPV

ABCF2

381

Q9UG63
FPACGPLEPYLPEPA

ALX3

51

O95076
VKPLLPPLPPDYGDG

AEBP1

291

Q8IUX7
PSPCLYEPLLGPAPV

ARMC5

731

Q96C12
YEPLLGPAPVPAPDL

ARMC5

736

Q96C12
EEPLLYIPPPPCQPL

ATF6

456

P18850
PCKLPCLSPPSYTFP

ESRP1

546

Q6NXG1
PSPPPLPRIYKPCFV

RARA

76

P10276
PSPLPPPRVYKPCFV

RARB

76

P10826
YIPGCLPAKSPDLGP

RIMBP3B

901

A6NNM3
YIPGCLPAKSPDLGP

RIMBP3C

901

A6NJZ7
VPVPFPIPEPDGCKS

NPC2

81

P61916
KSRDVYKLPPPTPPG

LIN37

156

Q96GY3
LPPLGTPVPPALYCQ

MADCAM1

191

Q13477
PEPLRSLVPYGPFPC

LLGL2

266

Q6P1M3
LPCNPPKGLPPLHIY

CHL1

151

O00533
GDKEKCYPPSPPPVS

MFHAS1

441

Q9Y4C4
CYPPSPPPVSKGIEV

MFHAS1

446

Q9Y4C4
TPPPCKSAAYLDPGP

NUDT17

296

P0C025
RLTVDAYPGLCPPPP

KSR2

226

Q6VAB6
TIKYCPLSKVPPPPA

NANOS1

261

Q8WY41
APPPPLNCPPGLEYL

PLSCR2

76

Q9NRY7
PKINPLTPFPGFYPC

PDE3B

396

Q13370
AAPPRLLPPLPTCYG

GLI1

986

P08151
LLPPLPTCYGPLKVG

GLI1

991

P08151
VPVTCDPPPPKFHGL

PAPPA

1411

Q13219
PPIPYSQKPAPEGSC

GREB1L

101

Q9C091
KLCSSLPGQGPPPYV

CASKIN2

741

Q8WXE0
PLDKYPLAPGVPLPS

PLCB3

441

Q01970
APRECLPPFLGVPKP

ARHGAP33

1036

O14559
TPICLPDYHKPLPPC

FZD5

91

Q13467
ILKTSPEPPCPEDYP

GRHL3

211

Q8TE85
PEPPCPEDYPSLKSD

GRHL3

216

Q8TE85
PPLSLGYGVCPEPPS

KLRG2

81

A4D1S0
PLKGCGAPQKYPPTP

HOXB3

311

P14651
TFLLPKSEPCPPGPE

ANGPT4

46

Q9Y264
PYHPSEPRAPCPIGK

CEP95

266

Q96GE4
PAGPCPPSPDLIYKI

EFS

116

O43281
PPYPVACPVPLELLA

GHRHR

106

Q02643
VIPDPSKYCGPYKPP

AGA

171

P20933
KYGPPCPSCPAPEFL

IGHG4

101

P01861
PPPGLSKFELCPKPD

HELZ2

81

Q9BYK8
CYPLLKLPLPGTGPV

SCAP

41

Q12770
IPYTAPELCAPPPLP

SBK2

221

P0C263
LLPAGPGPRLPKVYC

DENND2D

141

Q9H6A0
CSQLGLYPPEQLPPP

INCA1

71

Q0VD86
CHYFVKLVEGPPPPP

MRPL22

166

Q9NWU5
PYLLPPMPGPPCKVF

AK9

381

Q5TCS8
KPGLELAPAEPAYPP

SCRT2

61

Q9NQ03
TRSPAPGLCPIYKPP

SSPOP

66

A2VEC9
PGLCPIYKPPETRPA

SSPOP

71

A2VEC9
PYKPPYGKLLLPPGT

SYNE2

6486

Q8WXH0
YIPGCLPAKSPDLGP

RIMBP3

901

Q9UFD9
PPACPEPKYRGPLHC

SLC25A47

151

Q6Q0C1
LLPPCGYPGLKAEPA

WIPF3

266

A6NGB9
CLETYDKPPQPPPSR

KDF1

26

Q8NAX2
LHYPPPAKVPGLEPC

MLXIPL

396

Q9NP71
VPVPGYTKLPEPCPS

SPRR3

141

Q9UBC9
LPLPKPYGALAPFKP

CCDC146

921

Q8IYE0
PAGPHPDVFPPCKII

CLCA2

756

Q9UQC9
ELPPPPEPPGYVCSL

TTPAL

21

Q9BTX7
PPPPYSEVILKPSLG

TMEM92

116

Q6UXU6
LLPEKGCGLAPPHYP

ZNF384

36

Q8TF68
KPEPTYVSPPCPRLS

TICRR

1616

Q7Z2Z1
CKLPPPSAPASEYCP

WDR88

16

Q6ZMY6
PFKPPPPPIKYTCIQ

CD96

556

P40200
YLCDLAPEAPPPTLP

VWF

1456

P04275
PRLYKLCEPPPPAGE

PREX2

1591

Q70Z35
VACAKPPPLGLCDYP

TTLL12

561

Q14166
PPPPYEPHCASKVNL

TNFRSF19

141

Q9NS68
RDEGPPPAKFPCLSP

nan

271

A8MUI8
SCGKLPAPLSYVPVP

UGT2A3

181

Q6UWM9
KPLPHPPSLYCPENP

ZKSCAN2

941

Q63HK3
PPAEGKKLPTSPYPC

TESPA1

346

A2RU30
LKDDIPPIYPTSPGP

UHRF1BP1

1326

Q6BDS2
VKPYCPCAILSPLPP

ZNF619

476

Q8N2I2
CQPYVVKPVAPVAPP

KMT2D

1556

O14686
AVLSCLPEPPPPYEF

N4BP3

236

O15049