Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	intracellular chemical homeostasis	TRPM4 CXCR3 ABCA2 GPR27 F2RL3 GAS6 ABCB6 TF ADCY5 GSTP1 THADA BOK CCDC47 SCTR HTT SMAD4 PML	1.70e-06	866	105	17	GO:0055082
GeneOntologyBiologicalProcess	chemical homeostasis	TRPM4 CXCR3 ABCA2 GPR27 F2RL3 GAS6 HECTD4 ABCB6 TF ADCY5 GSTP1 THADA FBN1 FBN2 BOK CCDC47 SCTR HTT SMAD4 PML	4.27e-06	1249	105	20	GO:0048878
GeneOntologyBiologicalProcess	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	USE1 COPG2 GOLPH3 NBAS HTT	7.34e-06	53	105	5	GO:0006890
GeneOntologyBiologicalProcess	cellular homeostasis	TRPM4 CXCR3 ABCA2 GPR27 F2RL3 GAS6 ABCB6 TF ADCY5 GSTP1 THADA BOK CCDC47 SCTR HTT SMAD4 PML	8.97e-06	981	105	17	GO:0019725
GeneOntologyBiologicalProcess	maintenance of location	CXCR3 F2RL3 SREBF1 RNF213 GOLPH3 FBN1 FBN2 ASPM HTT PML	3.46e-05	396	105	10	GO:0051235
GeneOntologyBiologicalProcess	protein localization to extracellular region	SEL1L TRPM4 GPR27 SREBF1 COPG2 GOLPH3 ADCY5 FBN1 FBN2 AP1B1 HTT	4.06e-05	490	105	11	GO:0071692
GeneOntologyBiologicalProcess	sequestering of TGFbeta in extracellular matrix	FBN1 FBN2	1.53e-04	4	105	2	GO:0035583
GeneOntologyBiologicalProcess	metal ion transport	TRPM4 CXCR3 F2RL3 GAS6 LMTK2 ABCB6 TF KCNK4 JAK3 TMEM168 NFATC1 SLC23A2 CRBN HTT PML	1.61e-04	1000	105	15	GO:0030001
GeneOntologyBiologicalProcess	protein secretion	SEL1L TRPM4 GPR27 SREBF1 COPG2 GOLPH3 ADCY5 FBN1 AP1B1 HTT	1.70e-04	480	105	10	GO:0009306
GeneOntologyBiologicalProcess	establishment of protein localization to extracellular region	SEL1L TRPM4 GPR27 SREBF1 COPG2 GOLPH3 ADCY5 FBN1 AP1B1 HTT	1.79e-04	483	105	10	GO:0035592
GeneOntologyBiologicalProcess	regulation of mitochondrion organization	HDAC6 MYO19 SREBF1 GOLPH3 BOK HTT	1.81e-04	162	105	6	GO:0010821
GeneOntologyBiologicalProcess	monoatomic ion transport	TRPM4 CXCR3 F2RL3 GAS6 LMTK2 ABCB6 TF KCNK4 JAK3 PIEZO2 TMEM168 NFATC1 CLDN17 SLC19A1 SLC23A2 CRBN HTT PML	1.86e-04	1374	105	18	GO:0006811
GeneOntologyCellularComponent	endosome	MON2 ABCA2 LAMTOR2 HDAC6 TRIO LMTK2 RAPGEF1 ABCB6 GOLPH3 TF ADCY5 JAK3 BOK AP1B1 AP2B1 STOML1 SLC35D3 CNTNAP2 HTT PML	1.24e-06	1167	105	20	GO:0005768
GeneOntologyCellularComponent	early endosome	MON2 LMTK2 RAPGEF1 ABCB6 TF BOK AP1B1 SLC35D3 CNTNAP2 HTT PML	3.04e-05	481	105	11	GO:0005769
GeneOntologyCellularComponent	cytoplasmic vesicle membrane	MON2 ABCA2 LAMTOR2 SREBF1 SLC2A14 RAPGEF1 ABCB6 COPG2 TF LRIG3 BOK AP1B1 AP2B1 STOML1 SLC35D3 HTT PML	2.67e-04	1307	105	17	GO:0030659
GeneOntologyCellularComponent	vesicle membrane	MON2 ABCA2 LAMTOR2 SREBF1 SLC2A14 RAPGEF1 ABCB6 COPG2 TF LRIG3 BOK AP1B1 AP2B1 STOML1 SLC35D3 HTT PML	3.14e-04	1325	105	17	GO:0012506
GeneOntologyCellularComponent	vesicle coat	COPG2 TF AP1B1 AP2B1	3.61e-04	67	105	4	GO:0030120
GeneOntologyCellularComponent	ATP-binding cassette (ABC) transporter complex	ABCA2 ABCB6	3.70e-04	6	105	2	GO:0043190
GeneOntologyCellularComponent	coated vesicle	COL7A1 USE1 SREBF1 COPG2 TF AP1B1 AP2B1 HTT	4.68e-04	360	105	8	GO:0030135
GeneOntologyCellularComponent	multi-pass translocon complex	NCLN CCDC47	8.79e-04	9	105	2	GO:0160064
GeneOntologyCellularComponent	endosome membrane	MON2 ABCA2 LAMTOR2 ABCB6 TF BOK AP2B1 STOML1 SLC35D3 PML	9.04e-04	602	105	10	GO:0010008
GeneOntologyCellularComponent	microfibril	FBN1 FBN2	1.88e-03	13	105	2	GO:0001527
GeneOntologyCellularComponent	endoplasmic reticulum membrane	SEL1L CYP2D6 USE1 SREBF1 RDH14 ABCB6 COPG2 NCLN FAAH NBAS THADA BOK CCDC47 SLC35D3 PML	2.00e-03	1293	105	15	GO:0005789
GeneOntologyCellularComponent	membrane coat	COPG2 TF AP1B1 AP2B1	2.02e-03	106	105	4	GO:0030117
GeneOntologyCellularComponent	coated membrane	COPG2 TF AP1B1 AP2B1	2.02e-03	106	105	4	GO:0048475
GeneOntologyCellularComponent	endoplasmic reticulum subcompartment	SEL1L CYP2D6 USE1 SREBF1 RDH14 ABCB6 COPG2 NCLN FAAH NBAS THADA BOK CCDC47 SLC35D3 PML	2.09e-03	1299	105	15	GO:0098827
GeneOntologyCellularComponent	ER membrane insertion complex	NCLN CCDC47	2.19e-03	14	105	2	GO:0072379
Domain	ARM-like	MON2 MROH2A CUL9 COPG2 UNC45A IPO4 HEATR6 AP1B1 PELP1 AP2B1 ASPM HTT	3.47e-08	270	104	12	IPR011989
Domain	ARM-type_fold	MON2 MROH2A CUL9 COPG2 UNC45A IPO4 THADA HEATR6 AP1B1 PELP1 AP2B1 ASPM HTT	5.11e-08	339	104	13	IPR016024
Domain	-	MON2 CUL9 COPG2 UNC45A IPO4 HEATR6 AP1B1 AP2B1 ASPM HTT	4.53e-07	222	104	10	1.25.10.10
Domain	Coatomer/calthrin_app_sub_C	COPG2 AP1B1 AP2B1	9.20e-06	8	104	3	IPR009028
Domain	Clathrin_b-adaptin_app_Ig-like	AP1B1 AP2B1	3.07e-05	2	104	2	IPR013037
Domain	-	AP1B1 AP2B1	3.07e-05	2	104	2	2.60.40.1150
Domain	ABC_A	ABCA2 ABCA8 ABCA6	3.56e-05	12	104	3	IPR026082
Domain	Coatomer/clathrin_app_Ig-like	COPG2 AP1B1 AP2B1	3.56e-05	12	104	3	IPR013041
Domain	HEAT_REPEAT	MROH2A COPG2 IPO4 HEATR6 HTT	4.41e-05	70	104	5	PS50077
Domain	Clathrin/coatomer_adapt-like_N	COPG2 AP1B1 AP2B1	7.27e-05	15	104	3	IPR002553
Domain	Adaptin_N	COPG2 AP1B1 AP2B1	7.27e-05	15	104	3	PF01602
Domain	AP_complex_bsu_1_2_4	AP1B1 AP2B1	9.18e-05	3	104	2	IPR016342
Domain	B2-adapt-app_C	AP1B1 AP2B1	9.18e-05	3	104	2	PF09066
Domain	FBN	FBN1 FBN2	9.18e-05	3	104	2	IPR011398
Domain	ABC_tran	ABCA2 ABCB6 ABCA8 ABCA6	1.46e-04	48	104	4	PF00005
Domain	ABC_TRANSPORTER_2	ABCA2 ABCB6 ABCA8 ABCA6	1.46e-04	48	104	4	PS50893
Domain	ABC_TRANSPORTER_1	ABCA2 ABCB6 ABCA8 ABCA6	1.59e-04	49	104	4	PS00211
Domain	ABC_transporter-like	ABCA2 ABCB6 ABCA8 ABCA6	1.72e-04	50	104	4	IPR003439
Domain	rSAM_horseshoe	ELP3 CDK5RAP1	1.83e-04	4	104	2	IPR023404
Domain	B2-adapt-app_C	AP1B1 AP2B1	1.83e-04	4	104	2	SM01020
Domain	B-adaptin_app_sub_C	AP1B1 AP2B1	1.83e-04	4	104	2	IPR015151
Domain	-	ELP3 CDK5RAP1	1.83e-04	4	104	2	3.80.30.20
Domain	AP_beta	AP1B1 AP2B1	3.04e-04	5	104	2	IPR026739
Domain	cEGF	GAS6 FBN1 FBN2	3.97e-04	26	104	3	PF12662
Domain	cEGF	GAS6 FBN1 FBN2	3.97e-04	26	104	3	IPR026823
Domain	Beta2_adaptin/TBP_C_dom	AP1B1 AP2B1	4.54e-04	6	104	2	IPR012295
Domain	-	AP1B1 AP2B1	4.54e-04	6	104	2	3.30.310.10
Domain	CAMSAP_CH	ASPM VAV1	6.33e-04	7	104	2	PF11971
Domain	Elp3	ELP3 CDK5RAP1	6.33e-04	7	104	2	SM00729
Domain	TB	FBN1 FBN2	6.33e-04	7	104	2	PF00683
Domain	CAMSAP_CH	ASPM VAV1	6.33e-04	7	104	2	IPR022613
Domain	Elp3/MiaB/NifB	ELP3 CDK5RAP1	6.33e-04	7	104	2	IPR006638
Domain	-	FBN1 FBN2	8.41e-04	8	104	2	3.90.290.10
Domain	-	SEL1L UNC45A CCNF SMYD4 TTC7B PRPF39	1.06e-03	207	104	6	1.25.40.10
Domain	rSAM	ELP3 CDK5RAP1	1.08e-03	9	104	2	IPR007197
Domain	Alpha_adaptinC2	AP1B1 AP2B1	1.08e-03	9	104	2	PF02883
Domain	TB_dom	FBN1 FBN2	1.08e-03	9	104	2	IPR017878
Domain	Radical_SAM	ELP3 CDK5RAP1	1.08e-03	9	104	2	PF04055
Domain	Clathrin_a/b/g-adaptin_app_Ig	AP1B1 AP2B1	1.08e-03	9	104	2	IPR008152
Domain	Alpha_adaptinC2	AP1B1 AP2B1	1.08e-03	9	104	2	SM00809
Domain	TB	FBN1 FBN2	1.08e-03	9	104	2	PS51364
Domain	LAM_G_DOMAIN	LAMA1 GAS6 CNTNAP2	1.23e-03	38	104	3	PS50025
Domain	AAA	ABCA2 ABCB6 RNF213 ABCA8 ABCA6	1.27e-03	144	104	5	SM00382
Domain	AAA+_ATPase	ABCA2 ABCB6 RNF213 ABCA8 ABCA6	1.27e-03	144	104	5	IPR003593
Domain	Laminin_G_2	LAMA1 GAS6 CNTNAP2	1.43e-03	40	104	3	PF02210
Domain	Laminin_G_1	LAMA1 GAS6	1.63e-03	11	104	2	PF00054
Domain	LamG	LAMA1 GAS6 CNTNAP2	1.88e-03	44	104	3	SM00282
Domain	TPR-like_helical_dom	SEL1L UNC45A CCNF SMYD4 TTC7B PRPF39	1.94e-03	233	104	6	IPR011990
Domain	Armadillo	UNC45A AP1B1 AP2B1	2.28e-03	47	104	3	IPR000225
Domain	Cyclin_C-dom	CCND3 CCNF	3.95e-03	17	104	2	IPR004367
Domain	Cyclin_C	CCND3 CCNF	3.95e-03	17	104	2	PF02984
Domain	Cyclin_C	CCND3 CCNF	3.95e-03	17	104	2	SM01332
Domain	Laminin_G	LAMA1 GAS6 CNTNAP2	4.14e-03	58	104	3	IPR001791
Pathway	BIOCARTA_VITCB_PATHWAY	SLC2A14 P4HB SLC23A2	2.83e-05	12	73	3	MM1526
Pathway	KEGG_ABC_TRANSPORTERS	ABCA2 ABCB6 ABCA8 ABCA6	7.68e-05	44	73	4	M11911
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	MON2 RANBP10 TRPM4 TPST2 ABCA2 TRIO HECTD4 SREBF1 LMTK2 RAPGEF1 CUL9 NCLN CCND3 JAK3 THADA NFATC1 PROM2 NLRC5 HERC1 HTT	1.62e-10	1105	107	20	35748872
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	SEL1L MON2 RANBP10 USE1 MYO19 RNF213 COPG2 GOLPH3 UNC45A IPO4 NCLN CCND3 GSTP1 NBAS THADA COMMD4 PELP1 AP2B1 CCDC47 CUX1 PML	2.59e-09	1440	107	21	30833792
Pubmed	Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects.	TPST2 ABCA2 CYP2D6 CYP27A1 ABCB6 ABCA8 GSTP1 ABCA6	1.59e-07	193	107	8	19343046
Pubmed	Genotyping of eight polymorphic genes encoding drug-metabolizing enzymes and transporters using a customized oligonucleotide array.	CYP2D6 GSTP1 SLC19A1	1.57e-06	8	107	3	17113562
Pubmed	Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics.	SEL1L MON2 RNF213 IPO4 THADA AP2B1 P4HB	1.67e-06	183	107	7	23956138
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	MON2 HDAC6 ZNF618 GAS6 CUL9 RNF213 TF ABCA8 PARS2 LRIG3 THADA FBN2 ASPM VAV1 PML	1.72e-06	1116	107	15	31753913
Pubmed	A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.	TRPM4 USE1 ELP3 GSTP1 LRIG3 THADA AP1B1 P4HB STOML1 CDK5RAP1 HERC1 SLC23A2	2.30e-06	719	107	12	35337019
Pubmed	An Interaction Landscape of Ubiquitin Signaling.	ILF3 HDAC6 LAMA1 HECTD4 LMTK2 RNF213 SMYD4 AP2B1 HERC1 PML	2.48e-06	481	107	10	28190767
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	SEL1L TPST2 COL7A1 ABCA2 LAMA1 SREBF1 RNF213 NCLN THADA FBN1 FBN2 P4HB CCDC47 DNASE1L1 HTT	4.19e-06	1201	107	15	35696571
Pubmed	Homo- and heterotypic fibrillin-1 and -2 interactions constitute the basis for the assembly of microfibrils.	FBN1 FBN2	9.38e-06	2	107	2	12399449
Pubmed	Fibrillin-1 and fibrillin-2 are essential for formation of thick oxytalan fibers in human nonpigmented ciliary epithelial cells in vitro.	FBN1 FBN2	9.38e-06	2	107	2	21851253
Pubmed	New Evidence Supporting the Role of FBN1 in the Development of Adolescent Idiopathic Scoliosis.	FBN1 FBN2	9.38e-06	2	107	2	30044367
Pubmed	Material and mechanical properties of bones deficient for fibrillin-1 or fibrillin-2 microfibrils.	FBN1 FBN2	9.38e-06	2	107	2	21440062
Pubmed	MAGP-2 has multiple binding regions on fibrillins and has covalent periodic association with fibrillin-containing microfibrils.	FBN1 FBN2	9.38e-06	2	107	2	15131124
Pubmed	Microfibril structure masks fibrillin-2 in postnatal tissues.	FBN1 FBN2	9.38e-06	2	107	2	20404337
Pubmed	Fibrillln mutations in Marfan syndrome and related phenotypes.	FBN1 FBN2	9.38e-06	2	107	2	8791520
Pubmed	Fibrillin genes map to regions of conserved mouse/human synteny on mouse chromosomes 2 and 18.	FBN1 FBN2	9.38e-06	2	107	2	8307578
Pubmed	Developmental expression of fibrillin genes suggests heterogeneity of extracellular microfibrils.	FBN1 FBN2	9.38e-06	2	107	2	7744963
Pubmed	Fibrillin microfibrils in bone physiology.	FBN1 FBN2	9.38e-06	2	107	2	26408953
Pubmed	Arg-Gly-Asp-containing domains of fibrillins-1 and -2 distinctly regulate lung fibroblast migration.	FBN1 FBN2	9.38e-06	2	107	2	18006876
Pubmed	Rare variants in FBN1 and FBN2 are associated with severe adolescent idiopathic scoliosis.	FBN1 FBN2	9.38e-06	2	107	2	24833718
Pubmed	Nonselective assembly of fibrillin 1 and fibrillin 2 in the rodent ocular zonule and in cultured cells: implications for Marfan syndrome.	FBN1 FBN2	9.38e-06	2	107	2	24265020
Pubmed	In vivo studies of mutant fibrillin-1 microfibrils.	FBN1 FBN2	9.38e-06	2	107	2	20529844
Pubmed	Fibrillin-1 mutations causing Weill-Marchesani syndrome and acromicric and geleophysic dysplasias disrupt heparan sulfate interactions.	FBN1 FBN2	9.38e-06	2	107	2	23133647
Pubmed	The impact of CYP2D6*4 and GSTP1 Ile105Val polymorphisms on the susceptibility to develop BCR-ABL1 negative myeloproliferative neoplasms.	CYP2D6 GSTP1	9.38e-06	2	107	2	32918123
Pubmed	Linkage of Marfan syndrome and a phenotypically related disorder to two different fibrillin genes.	FBN1 FBN2	9.38e-06	2	107	2	1852206
Pubmed	Fibrillins can co-assemble in fibrils, but fibrillin fibril composition displays cell-specific differences.	FBN1 FBN2	9.38e-06	2	107	2	12429739
Pubmed	Fibrillin-1 and fibrillin-2 in human embryonic and early fetal development.	FBN1 FBN2	9.38e-06	2	107	2	12524050
Pubmed	Structure and expression of fibrillin-2, a novel microfibrillar component preferentially located in elastic matrices.	FBN1 FBN2	9.38e-06	2	107	2	8120105
Pubmed	The fibrillinopathies: New insights with focus on the paradigm of opposing phenotypes for both FBN1 and FBN2.	FBN1 FBN2	9.38e-06	2	107	2	35419902
Pubmed	Fibrillin assembly: dimer formation mediated by amino-terminal sequences.	FBN1 FBN2	9.38e-06	2	107	2	10504303
Pubmed	SEL1L degradation intermediates stimulate cytosolic aggregation of polyglutamine-expanded protein.	SEL1L HTT	9.38e-06	2	107	2	33576152
Pubmed	Evaluation of the binding affinity of E3 ubiquitin ligase ligands by cellular target engagement and in-cell ELISA assay.	HDAC6 CRBN	9.38e-06	2	107	2	33532735
Pubmed	Immunohistochemical expression of fibrillin-1 and fibrillin-2 during tooth development.	FBN1 FBN2	9.38e-06	2	107	2	25524144
Pubmed	Fibrillins 1 and 2 perform partially overlapping functions during aortic development.	FBN1 FBN2	9.38e-06	2	107	2	16407178
Pubmed	N-terminal domains of fibrillin 1 and fibrillin 2 direct the formation of homodimers: a possible first step in microfibril assembly.	FBN1 FBN2	9.38e-06	2	107	2	10359653
Pubmed	Polymorphism in Cytochrome P450 2D6, Glutathione S-Transferases Pi 1 Genes, and Organochlorine Pesticides in Alzheimer Disease: A Case-Control Study in North Indian Population.	CYP2D6 GSTP1	9.38e-06	2	107	2	24584466
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	TRPM4 IL17REL TRIO GAS6 HECTD4 RNF213 CCND3 EXD3 THADA NFATC1 PROM2 SLC19A1 CDK5RAP1 NLRC5 CUX1 HTT	1.29e-05	1489	107	16	28611215
Pubmed	CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI.	RNF213 COPG2 NCLN HEATR6 HTT	1.81e-05	104	107	5	31240132
Pubmed	CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.	MON2 HDAC6 MYO19 UNC45A IPO4 NCLN PARS2 NFATC1 CCDC47 CDK5RAP1	1.85e-05	606	107	10	36538041
Pubmed	ADAMTS18-fibronectin interaction regulates the morphology of liver sinusoidal endothelial cells.	LAMA1 FBN1 FBN2	2.23e-05	18	107	3	39040056
Pubmed	Targeting RICTOR Sensitizes SMAD4-Negative Colon Cancer to Irinotecan.	HDAC6 HECTD4 METAP1 HEATR6 PRPF39 SMAD4	2.27e-05	183	107	6	31932471
Pubmed	Interaction of tropoelastin with the amino-terminal domains of fibrillin-1 and fibrillin-2 suggests a role for the fibrillins in elastic fiber assembly.	FBN1 FBN2	2.81e-05	3	107	2	10825173
Pubmed	HDAC6 and microtubules are required for autophagic degradation of aggregated huntingtin.	HDAC6 HTT	2.81e-05	3	107	2	16192271
Pubmed	Selective activation of NFAT by promyelocytic leukemia protein.	NFATC1 PML	2.81e-05	3	107	2	18246125
Pubmed	Adamts10 inactivation in mice leads to persistence of ocular microfibrils subsequent to reduced fibrillin-2 cleavage.	FBN1 FBN2	2.81e-05	3	107	2	30201140
Pubmed	Association of A313 G polymorphism (GSTP1*B) in the glutathione-S-transferase P1 gene with sporadic Parkinson's disease.	CYP2D6 GSTP1	2.81e-05	3	107	2	17250723
Pubmed	Vav exchange factor counteracts the HIV-1 Nef-mediated decrease of plasma membrane GM1 and NF-AT activity in T cells.	NFATC1 VAV1	2.81e-05	3	107	2	12884293
Pubmed	Mutant huntingtin interacts with the sterol regulatory element-binding proteins and impairs their nuclear import.	SREBF1 HTT	2.81e-05	3	107	2	31875875
Pubmed	Fibrillin-1 directly regulates osteoclast formation and function by a dual mechanism.	FBN1 NFATC1	2.81e-05	3	107	2	24039232
Pubmed	Fibrillin-1 and -2 differentially modulate endogenous TGF-β and BMP bioavailability during bone formation.	FBN1 FBN2	2.81e-05	3	107	2	20855508
Pubmed	Characterization of a complex phenotype (fever-dependent recurrent acute liver failure and osteogenesis imperfecta) due to NBAS and P4HB variants.	NBAS P4HB	2.81e-05	3	107	2	33707149
Pubmed	The relationship between HDAC6, CXCR3, and SIRT1 genes expression levels with progression of primary open-angle glaucoma.	CXCR3 HDAC6	2.81e-05	3	107	2	29384425
Pubmed	[Association between CYP2B6, CYP2D6, GSTP1 genetic polymorphisms and urinary styrene metabolites in professional workers].	CYP2D6 GSTP1	2.81e-05	3	107	2	20137387
Pubmed	A three-gene DNA methylation biomarker accurately classifies early stage prostate cancer.	GAS6 GSTP1	2.81e-05	3	107	2	31433512
Pubmed	Flavopiridol pharmacogenetics: clinical and functional evidence for the role of SLCO1B1/OATP1B1 in flavopiridol disposition.	ABCA2 CYP2D6 GSTP1	3.11e-05	20	107	3	21072184
Pubmed	Quantitative targeted absolute proteomic analysis of transporters, receptors and junction proteins for validation of human cerebral microvascular endothelial cell line hCMEC/D3 as a human blood-brain barrier model.	ABCA2 ABCA6 SLC19A1	3.62e-05	21	107	3	23137377
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	TRIO UNC45A IPO4 NBAS HEATR6 CNTNAP2	3.96e-05	202	107	6	33005030
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	SEL1L MON2 RANBP10 UNC45A IPO4 NCLN ELP3 TF FBN2 AP1B1 AP2B1 P4HB	4.70e-05	974	107	12	28675297
Pubmed	Human eye development is characterized by coordinated expression of fibrillin isoforms.	FBN1 FBN2	5.60e-05	4	107	2	25406291
Pubmed	Extracellular microfibrils control osteoblast-supported osteoclastogenesis by restricting TGF{beta} stimulation of RANKL production.	FBN1 FBN2	5.60e-05	4	107	2	20729550
Pubmed	Heparin/heparan sulfate controls fibrillin-1, -2 and -3 self-interactions in microfibril assembly.	FBN1 FBN2	5.60e-05	4	107	2	25034023
Pubmed	Maternal fine particulate matter exposure, polymorphism in xenobiotic-metabolizing genes and offspring birth weight.	CYP2D6 GSTP1	5.60e-05	4	107	2	20656020
Pubmed	Characterization of murine CD70 by molecular cloning and mAb.	LAMA1 VAV1	5.60e-05	4	107	2	9620608
Pubmed	Immunohistochemical detection of EGFR, fibrillin-2, P-cadherin and AP2beta as biomarkers for rhabdomyosarcoma diagnostics.	FBN2 AP2B1	5.60e-05	4	107	2	19469909
Pubmed	ABCG1 (ABC8), the human homolog of the Drosophila white gene, is a regulator of macrophage cholesterol and phospholipid transport.	ABCA2 ABCA6	5.60e-05	4	107	2	10639163
Pubmed	Association of epidermal growth factor receptors with coated pit adaptins via a tyrosine phosphorylation-regulated mechanism.	AP1B1 AP2B1	5.60e-05	4	107	2	7534311
Pubmed	Latent transforming growth factor beta-binding protein 1 interacts with fibrillin and is a microfibril-associated protein.	FBN1 FBN2	5.60e-05	4	107	2	12429738
Pubmed	Role of activation of PIP5Kgamma661 by AP-2 complex in synaptic vesicle endocytosis.	AP1B1 AP2B1	5.60e-05	4	107	2	17290217
Pubmed	Non-enzymatic developmental functions of acetylcholinesterase--the question of redundancy.	LAMA1 GAS6	5.60e-05	4	107	2	18785927
Pubmed	Comprehensive genetic analysis of relevant four genes in 49 patients with Marfan syndrome or Marfan-related phenotypes.	FBN1 FBN2	5.60e-05	4	107	2	16835936
Pubmed	Glucose transporter 3 is a rab11-dependent trafficking cargo and its transport to the cell surface is reduced in neurons of CAG140 Huntington's disease mice.	SLC2A14 HTT	5.60e-05	4	107	2	25526803
Pubmed	ATM binds to beta-adaptin in cytoplasmic vesicles.	AP1B1 AP2B1	5.60e-05	4	107	2	9707615
Pubmed	Adamts18 modulates the development of the aortic arch and common carotid artery.	LAMA1 FBN1 FBN2	6.99e-05	26	107	3	34189436
Pubmed	Structure--function relationships in HIV-1 Nef.	AP1B1 AP2B1 VAV1	7.85e-05	27	107	3	11463741
Pubmed	Global landscape of HIV-human protein complexes.	SEL1L RNF213 GOLPH3 UNC45A IPO4 FBN2 P4HB CCDC47	8.76e-05	457	107	8	22190034
Pubmed	Autism candidate gene DIP2A regulates spine morphogenesis via acetylation of cortactin.	HDAC6 ELP3 CUX1	8.77e-05	28	107	3	31600191
Pubmed	Characterization of Microfibrillar-associated Protein 4 (MFAP4) as a Tropoelastin- and Fibrillin-binding Protein Involved in Elastic Fiber Formation.	FBN1 FBN2	9.32e-05	5	107	2	26601954
Pubmed	GST CYP and PON1 polymorphisms in farmers attributing ill health to organophosphate-containing sheep dip.	CYP2D6 GSTP1	9.32e-05	5	107	2	17536768
Pubmed	Activating mutations in human acute megakaryoblastic leukemia.	JAK3 PML	9.32e-05	5	107	2	18755984
Pubmed	Evolutionary analysis of a cluster of ATP-binding cassette (ABC) genes.	ABCA8 ABCA6	9.32e-05	5	107	2	12532264
Pubmed	Genetic polymorphisms associated with adverse events and elimination of methotrexate in childhood acute lymphoblastic leukemia and malignant lymphoma.	GSTP1 SLC19A1	9.32e-05	5	107	2	17180579
Pubmed	Development, composition, and structural arrangements of the ciliary zonule of the mouse.	FBN1 FBN2	9.32e-05	5	107	2	23493297
Pubmed	Piezo1 and Piezo2 foster mechanical gating of K2P channels.	KCNK4 PIEZO2	9.32e-05	5	107	2	34852225
Pubmed	Genetic association of phase I and phase II detoxification genes with recurrent miscarriages among North Indian women.	CYP2D6 GSTP1	9.32e-05	5	107	2	19892789
Pubmed	Relaxin regulates fibrillin 2, but not fibrillin 1, mRNA and protein expression by human dermal fibroblasts and murine fetal skin.	FBN1 FBN2	9.32e-05	5	107	2	12590922
Pubmed	Loss of Elp3 Impairs the Acetylation and Distribution of Connexin-43 in the Developing Cerebral Cortex.	HDAC6 ELP3	9.32e-05	5	107	2	28507509
Pubmed	CYP1A2, CYP2D6, GSTM1, GSTP1, and GSTT1 gene polymorphisms in patients with bladder cancer in a Turkish population.	CYP2D6 GSTP1	9.32e-05	5	107	2	18690546
Pubmed	Fibrillin-1 interactions with fibulins depend on the first hybrid domain and provide an adaptor function to tropoelastin.	FBN1 FBN2	9.32e-05	5	107	2	17255108
Pubmed	POGLUT2 and POGLUT3 O-glucosylate multiple EGF repeats in fibrillin-1, -2, and LTBP1 and promote secretion of fibrillin-1.	FBN1 FBN2	9.32e-05	5	107	2	34411563
Pubmed	Interactions of the amino-terminal noncollagenous (NC1) domain of type VII collagen with extracellular matrix components. A potential role in epidermal-dermal adherence in human skin.	COL7A1 LAMA1	9.32e-05	5	107	2	9169408
Pubmed	Endocytosis of the glucose transporter GLUT8 is mediated by interaction of a dileucine motif with the beta2-adaptin subunit of the AP-2 adaptor complex.	AP1B1 AP2B1	9.32e-05	5	107	2	16723738
Pubmed	EDEM1 Drives Misfolded Protein Degradation via ERAD and Exploits ER-Phagy as Back-Up Mechanism When ERAD Is Impaired.	SEL1L P4HB CCDC47 HERC1 HTT	1.04e-04	150	107	5	32423001
Pubmed	Heritable Thoracic Aortic Disease Overview	FBN1 FBN2 SMAD4	1.08e-04	30	107	3	20301299
Pubmed	Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.	SEL1L MON2 RANBP10 COPG2 NCLN FBN1 FBN2 HEATR6 P4HB CUX1	1.15e-04	754	107	10	33060197
Pubmed	Absence of canonical Smad signaling in ureteral and bladder mesenchyme causes ureteropelvic junction obstruction.	COL7A1 LAMA1 SMAD4	1.20e-04	31	107	3	22282597
Pubmed	GOLPH3 and GOLPH3L are broad-spectrum COPI adaptors for sorting into intra-Golgi transport vesicles.	TPST2 COPG2 GOLPH3	1.32e-04	32	107	3	34473204
Pubmed	Molecular identification and functional characterization of the vitamin C transporters expressed by Sertoli cells.	SLC2A14 SLC23A2	1.40e-04	6	107	2	18668520
Pubmed	Genetic polymorphisms in oestrogen metabolic pathway and breast cancer: a positive association with combined CYP/GST genotypes.	CYP2D6 GSTP1	1.40e-04	6	107	2	18618215
Pubmed	Clathrin.	AP1B1 AP2B1	1.40e-04	6	107	2	10966473
Interaction	C3orf52 interactions	TRPM4 ABCA2 USE1 SREBF1 RDH14 COPG2 FAAH NBAS TMEM168 SLC23A2 CUX1 PML	5.21e-08	305	103	12	int:C3orf52
Interaction	TOP3B interactions	MON2 RANBP10 TRPM4 TPST2 ABCA2 TRIO HECTD4 SREBF1 LMTK2 RAPGEF1 CUL9 UNC45A IPO4 NCLN CCND3 CCNF JAK3 THADA PELP1 NFATC1 PROM2 NLRC5 HERC1 HTT	2.78e-07	1470	103	24	int:TOP3B
Interaction	TRIM66 interactions	MON2 GAS6 CUL9 RNF213 LRIG3 THADA FBN2 ASPM PML	1.08e-06	205	103	9	int:TRIM66
Interaction	GPR182 interactions	MON2 ABCA2 MYO19 ABCB6 RNF213 NCLN FAAH THADA HEATR6 CCDC47 CUX1 HTT	3.62e-06	455	103	12	int:GPR182
Interaction	AP1G1 interactions	GOLPH3 CCNF AP1B1 AP2B1 HTT SMAD4 PML	1.20e-05	150	103	7	int:AP1G1
Interaction	ABCA6 interactions	ABCA2 ABCA8 ABCA6	1.52e-05	10	103	3	int:ABCA6
Interaction	FAM174A interactions	MYO19 RNF213 IPO4 THADA HEATR6 TMEM168 CCDC47 CDK5RAP1	1.97e-05	224	103	8	int:FAM174A
Interaction	P2RY6 interactions	SEL1L MON2 COPG2 GOLPH3 UNC45A IPO4 NCLN NBAS CCDC47 CUX1	2.80e-05	385	103	10	int:P2RY6
Interaction	FLOT1 interactions	SEL1L LAMTOR2 HDAC6 TRIO MYO19 LMTK2 RAPGEF1 SLC19A1 CNTNAP2 VAV1 HTT	3.15e-05	475	103	11	int:FLOT1
Interaction	ARFGAP1 interactions	COPG2 AP1B1 AP2B1 CNTNAP2 HTT PML	6.79e-05	135	103	6	int:ARFGAP1
GeneFamily	ATP binding cassette subfamily A	ABCA2 ABCA8 ABCA6	1.72e-05	14	67	3	805
GeneFamily	BCL2 family	BCL2L15 BOK	1.20e-03	14	67	2	1057
ToppCell	10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-E\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ABCA2 TF ADCY5 ABCA8 PIEZO2 BOK	7.49e-06	194	107	6	cb0422e7607dbd77204428b7e2c70dfe14a6ca11
ToppCell	human_hepatoblastoma-NK.T_cells\|human_hepatoblastoma / Sample and Cell Type and Tumor Cluster (all cells)	CXCR3 PBX4 CCND3 JAK3 NFATC1 NLRC5	7.49e-06	194	107	6	997b02a22d7c89a8fd5615bb79a2a8a34fc3fee6
ToppCell	tumor_Lung-B_lymphocytes-MALT_B_cells\|B_lymphocytes / Location, Cell class and cell subclass	SEL1L TPST2 GAS6 NCLN GSTP1 P4HB	7.94e-06	196	107	6	1f63dba9d226e4a42d9bee7258580a1e547c0e92
ToppCell	10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-B\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ABCA2 SREBF1 TF ADCY5 PIEZO2 BOK	8.17e-06	197	107	6	82b8e22317cad6d3786bd70d91107007c0ccd7cd
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ABCA8 SSC5D PIEZO2 FBN1 ABCA6 P4HB	8.17e-06	197	107	6	6b6440f1baad5680cf9e13ca3ab72a2c65523d59
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ABCA2 LDOC1 TF ABCA8 FAAH BOK	8.91e-06	200	107	6	829978708463a7459fe1041bd90196775bc4b531
ToppCell	Bac-SEP-Myeloid-tDC\|Bac-SEP / Disease, Lineage and Cell Type	TRIO USE1 ZNF618 GAS6 HSD11B1L	4.91e-05	165	107	5	8728f927502e56f2768b4224e9111939d3d7815a
ToppCell	356C-Fibroblasts-Fibroblast-D\|356C / Donor, Lineage, Cell class and subclass (all cells)	COL7A1 GPR27 LAMA1 ABCA8 PIEZO2	5.05e-05	166	107	5	7286a37b2827f3747469ffd0d76cbe81116db7ee
ToppCell	356C-Fibroblasts-Fibroblast-D-\|356C / Donor, Lineage, Cell class and subclass (all cells)	COL7A1 GPR27 LAMA1 ABCA8 PIEZO2	5.05e-05	166	107	5	7c2eee0a4f45795a956acf936b85bdb35f1b1624
ToppCell	BAL-Control-cDC_6\|Control / Compartment, Disease Groups and Clusters	GOLPH3 EEF2KMT PELP1 ASPM SLC23A2	5.35e-05	168	107	5	65ec473cff748b334c0a66e33bc34a8465fe7631
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	COL7A1 ABCA8 FBN1 FBN2 ABCA6	5.50e-05	169	107	5	c0824a93674e2bff0f09b2d2fab5bab016a2e379
ToppCell	droplet-Lung-nan-3m-Myeloid-plasmacytoid_dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ILF3 MYO19 CYP27A1 ADCY5 STOML1	6.14e-05	173	107	5	1b9b4e165121b08ef15a93fca6bea875cae69f19
ToppCell	facs-Brain_Non-Myeloid-Cerebellum_-18m-Epithelial-neuronal_stem_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF618 SSC5D PIEZO2 ASPM SCTR	6.14e-05	173	107	5	f38bf7584e08d15a6e2c116b7c3551ba475a5e14
ToppCell	droplet-Lung-nan-3m-Myeloid-Plasmacytoid_Dendritic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ILF3 MYO19 CYP27A1 ADCY5 STOML1	6.14e-05	173	107	5	c25f24d7b672c9686d31ebc8d263042282f520fd
ToppCell	3'-GW_trimst-1-LargeIntestine-Hematopoietic-Myeloid-Megakaryocyte\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TPST2 F2RL3 CCND3 SLC35D3 NLRC5	6.49e-05	175	107	5	901f0181a30e5cc609dcada8d8a59f0468df6fa5
ToppCell	CV-Severe-7\|CV / Virus stimulation, Condition and Cluster	SEL1L RNF213 TMEM168 CDK5RAP1 HTT	6.66e-05	176	107	5	3de0c7d77210049e5616db21eed1490a17a5ec2d
ToppCell	356C-Fibroblasts-Fibroblast-C_(Myofibroblast)-\|356C / Donor, Lineage, Cell class and subclass (all cells)	ABCA8 PIEZO2 FBN1 ABCA6 SLC35D3	6.84e-05	177	107	5	cdfd2f0ee2f692271b1525e414b0f645cdadb1f6
ToppCell	CV-Severe-7\|Severe / Virus stimulation, Condition and Cluster	RNF213 NBAS TMEM168 CDK5RAP1 HTT	6.84e-05	177	107	5	82fdd6185b368f54f03de389427cbe3071d21a99
ToppCell	356C-Fibroblasts-Fibroblast-C_(Myofibroblast)\|356C / Donor, Lineage, Cell class and subclass (all cells)	ABCA8 PIEZO2 FBN1 ABCA6 SLC35D3	6.84e-05	177	107	5	db222faaecbe5600da39277243c4e7e764eb63c9
ToppCell	3'-GW_trimst-1-SmallIntestine-Hematopoietic-Myeloid-Megakaryocyte\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TPST2 F2RL3 CCND3 SLC35D3 NLRC5	7.22e-05	179	107	5	8d9bad6507fac0926163807a0bda62a57e7660e3
ToppCell	3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ABCA8 TRIL SSC5D FBN1 ABCA6	7.81e-05	182	107	5	d179b5deb07c20d49eb6c58d5a65904f8921de3a
ToppCell	PND10-Immune-Immune_Myeloid-Dendritic-cDC1\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HDAC6 TRIO PELP1 ASPM VAV1	8.01e-05	183	107	5	ab38264daddccdf5ffb75ff2210b27423eca6bc0
ToppCell	PND10-Immune-Immune_Myeloid-Dendritic\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HDAC6 TRIO PELP1 ASPM VAV1	8.01e-05	183	107	5	e4911601dca2c0ecb448cdb6b222dedfc0c8bf6c
ToppCell	PND10-Immune-Immune_Myeloid-Dendritic-cDC1-cDC1_G2M\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HDAC6 TRIO PELP1 ASPM VAV1	8.01e-05	183	107	5	263bfa1d8a7314bc3156c735c403c3bab8ea4dac
ToppCell	Primary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte-Oligo_L4-6_OPALIN\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ABCA2 TF ABCA8 PIEZO2 BOK	8.01e-05	183	107	5	5472cdce6d99314d229418412acf1fff6340db7d
ToppCell	Calu_3-infected\|Calu_3 / Cell line, Condition and Strain	COL7A1 TRIO RNF213 NLRC5 PML	8.01e-05	183	107	5	8f7f5000645f24f20a8d7700c4df1f8953a1780b
ToppCell	Primary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ABCA2 CYP27A1 TF ABCA8 PIEZO2	8.22e-05	184	107	5	5939527d24d299e562e707469c9123890edd76be
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte-Oligo_L4-6_OPALIN\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ABCA2 TF ABCA8 PIEZO2 BOK	8.43e-05	185	107	5	1d731d69d8db8aef4a11439b8abd1030c7e6ac4c
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ABCA2 TF ABCA8 PIEZO2 BOK	8.43e-05	185	107	5	b8d02c9426740ffcb69d2e6f95473b388149d297
ToppCell	Primary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte-Oligo_L4-6_MOBP_COL18A1\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ABCA2 CYP27A1 TF ABCA8 PIEZO2	8.65e-05	186	107	5	d57c40b3fe5cfc87e771df76533d9a3e94678b04
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TRPM4 TF P4HB PROM2 TMEM238	8.87e-05	187	107	5	71d99a1a95d3692a2891da49d4a243bae6e07fd0
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ABCA2 CYP27A1 TF ABCA8 PIEZO2	9.09e-05	188	107	5	14072d0b82df55711d5356b2209f4f0bdd90dc27
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Oligo\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CYP27A1 TF ABCA8 PIEZO2 BOK	9.09e-05	188	107	5	60242c29c7f16c94a84685d3bc4ed93a66e70152
ToppCell	human_hepatoblastoma-NK.T_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	PBX4 CCND3 JAK3 NFATC1 NLRC5	9.09e-05	188	107	5	71b7599e7e1d63cc0c8518c0501533755951d58f
ToppCell	primary_auditory_cortex_(A1C)-Non-neuronal-Macroglial-Oligo\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ABCA2 CYP27A1 TF ABCA8 PIEZO2	9.09e-05	188	107	5	b04fd6a724c117eb9a979c29b91f90113feb7a5c
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Oligo\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ABCA2 CYP27A1 TF ABCA8 PIEZO2	9.32e-05	189	107	5	70eea8c94fa56bb15bee8065de47acea156794e9
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte-Oligo_L4-6_OPALIN\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ABCA2 CYP27A1 TF ABCA8 PIEZO2	9.32e-05	189	107	5	b60c8a29d3169c4830fe63b01db90c57660fc239
ToppCell	metastatic_Lymph_Node-B_lymphocytes-MALT_B_cells\|B_lymphocytes / Location, Cell class and cell subclass	SEL1L TPST2 GAS6 GSTP1 P4HB	9.56e-05	190	107	5	5ec49cc7692053c1a525ca9137c996ccd2794e1c
ToppCell	ILEUM-inflamed-(5)_IgG_plasma_cells\|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	SEL1L TPST2 GAS6 NCLN P4HB	9.56e-05	190	107	5	76baa41b217ae6fd62a58971912e8ecfe1dc03e7
ToppCell	Primary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte-Oligo_L4-6_MOBP_COL18A1\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ABCA2 CYP27A1 TF ABCA8 PIEZO2	9.56e-05	190	107	5	396b7225c2430db3dc55a3d0db70239b71987229
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Immune-Lymphocytic_T/NK-T_Cell-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PBX4 CCND3 JAK3 NLRC5 VAV1	9.80e-05	191	107	5	1a2d5fec2bea96da2154b0aed252f1bb35102f6e
ToppCell	ASK454-Mesenchymal\|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq	TRIL SSC5D PIEZO2 FBN1 ABCA6	9.80e-05	191	107	5	e30ae7a12439f8a79820b13f03e822c1223fd0cb
ToppCell	Adult-Immune-natural_killer_cell\|Adult / Lineage, Cell type, age group and donor	CXCR3 ABCA2 CCND3 JAK3 NLRC5	9.80e-05	191	107	5	758ec27e47d7662a5175305e98a1506c6859dbf7
ToppCell	ASK454-Mesenchymal-Fibroblast\|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq	TRIL SSC5D PIEZO2 FBN1 ABCA6	9.80e-05	191	107	5	1726add3f392a061536b7aff72ba84303f4a0b1f
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Immune-Lymphocytic_T/NK-T_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PBX4 CCND3 JAK3 NLRC5 VAV1	9.80e-05	191	107	5	326b4541069efedc8ab409f85bb11f77346dda90
ToppCell	10x5'-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8\|lymph-node_spleen / Manually curated celltypes from each tissue	MON2 RNF213 PBX4 JAK3 HERC1	1.00e-04	192	107	5	47646d7e4990be85072987f92bf18d52f8da752e
ToppCell	Adult-Immune-alveolar_macrophage_(MARCO_positive)-D175\|Adult / Lineage, Cell type, age group and donor	CYP27A1 RAPGEF1 NCLN TTC7B SLC23A2	1.00e-04	192	107	5	733491e932350e3c216a626cc49c3cd3fe970a82
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_2_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ABCA8 SSC5D PIEZO2 FBN1 ABCA6	1.00e-04	192	107	5	e0f4e4470a71bfa81d9dcd8594e5f82aafc24f81
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts-Peribronchial_fibroblasts_L.2.1.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ABCA8 SSC5D PIEZO2 FBN1 ABCA6	1.00e-04	192	107	5	c5f8e766453f87847b740d6988c524b3d0ef3765
ToppCell	10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-Z\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ABCA2 TF ABCA8 PIEZO2 BOK	1.00e-04	192	107	5	8dc3016601148243196e925641c9507e9d58c9e0
ToppCell	Mesenchymal-matrix_fibroblast_1_cell\|World / Lineage, Cell type, age group and donor	ABCA8 PIEZO2 FBN1 ABCA6 CNTNAP2	1.03e-04	193	107	5	acad568621ed677031797b8c2e34dafea798d681
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ABCA8 PIEZO2 FBN1 ABCA6 CNTNAP2	1.05e-04	194	107	5	011e14d9ed1393275f892060e7708ffadcd0767f
ToppCell	metastatic_Brain-B_lymphocytes-Plasma_cells\|B_lymphocytes / Location, Cell class and cell subclass	SEL1L TPST2 GAS6 NCLN GSTP1	1.05e-04	194	107	5	69828d24b3e182f26aa15eb0ae5aa21c640c2922
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL7A1 TRIO RNF213 CCND3 SCTR	1.08e-04	195	107	5	938b31dbf1674ee6fd0123bc88391ddcaf151217
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature3_(17)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	ABCA8 TRIL PIEZO2 ABCA6 CNTNAP2	1.08e-04	195	107	5	1cdf5f296029ae424d9dba42e86a6d111e4896e6
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ABCA8 SSC5D PIEZO2 FBN1 ABCA6	1.08e-04	195	107	5	1236dc60288c7dd91868e86e9174a2dacd3b11b3
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL7A1 TRIO RNF213 CCND3 SCTR	1.08e-04	195	107	5	d39e9e6544f49e677ebe528c6fe60b99a3630e30
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)\|renal_medulla_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group	COL7A1 RNF213 P4HB NLRC5 SCTR	1.08e-04	195	107	5	633c7668fe365f7b0f7851cdc442d5dd89c454e2
ToppCell	Bronchial-NucSeq-Epithelial-Epi_submucosal-gland-Myoepithelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	COL7A1 KCTD8 LAMA1 ADCY5 FBN2	1.11e-04	196	107	5	a58bdf9de05d13d84211e09a933679d485bf8ab4
ToppCell	Parenchymal-10x5prime-Stromal-Fibroblastic-Fibro_immune_recruiting\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	ABCB6 ADCY5 KCNK4 PIEZO2 FBN1	1.11e-04	196	107	5	614a07334707eafe238d5cb7b080a3ca796a1920
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-B\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ABCA2 CYP27A1 TF ABCA8 BOK	1.13e-04	197	107	5	032ccc91e604113da9bc34a6f9ddb1d45dea1892
ToppCell	PCW_13-14-Mesenchymal\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	ABCA8 PIEZO2 FBN1 ABCA6 CNTNAP2	1.13e-04	197	107	5	73a2085d2682d636726a5432d572ae2a3fbe1c3f
ToppCell	B_cells-Plasma_cells_and_plasmablasts\|B_cells / Immune cells in Kidney/Urine in Lupus Nephritis	SEL1L TPST2 GAS6 GSTP1 P4HB	1.13e-04	197	107	5	3b1c574b3d119b63967bb1306f0353ecc4c522f3
ToppCell	B_cells-Plasmablasts\|B_cells / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	SEL1L TPST2 GAS6 GSTP1 P4HB	1.16e-04	198	107	5	c6cab47885be74a64351f843a741dea6d911bde4
ToppCell	LPS_IL1RA_TNF-Epithelial_alveolar-AT_2\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	TF FAAH SMYD4 P4HB TMEM238	1.16e-04	198	107	5	aa80315395cb5dffc25927c8a77cd2037aea8772
ToppCell	Parenchymal-10x3prime_v2-Immune_Lymphocytic-T-T_CD4-CD4_TRM/EMRA\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	CXCR3 PBX4 JAK3 ASPM VAV1	1.19e-04	199	107	5	5a29db2610ba06a2248325a16cad755d20debf2c
ToppCell	Tracheal-NucSeq-Immune_Lymphocytic-T-T_CD4-CD4_naive/CM\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PBX4 CCND3 JAK3 NLRC5 VAV1	1.19e-04	199	107	5	6150b272313d3fbf5ddcb3a8d51862d368220fe2
ToppCell	Sepsis-Bac-SEP-Myeloid-tDC\|Bac-SEP / Disease, condition lineage and cell class	TRIO USE1 ZNF618 GAS6 HSD11B1L	1.19e-04	199	107	5	a2be40d367338d32348a6906c8475aa3b544a0f7
ToppCell	distal-2-mesenchymal-Adventitial_Fibroblast\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ABCA8 TRIL SSC5D FBN1 ABCA6	1.19e-04	199	107	5	97b475f9110ef7bb29d9cf2109b7e43177830f05
ToppCell	10x3'2.3-week_17-19-Mesenchymal_fibro-stroma-arteriolar_fibroblast\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	TRIL LRIG3 PIEZO2 FBN1 ABCA6	1.19e-04	199	107	5	95d95e9b7bd3933188998ae94986213eb0f1e5ea
ToppCell	PBMC-Severe\|PBMC / Compartment, Disease Groups and Clusters	GPR27 GAS6 RNF213 CCND3 JAK3	1.19e-04	199	107	5	b428d95d3c90b28f658f652a768588a8ced4abd9
ToppCell	Caecum-(2)_B_cell-(20)_B_cell_IgA_Plasma\|Caecum / shred on region, Cell_type, and subtype	SEL1L TPST2 GAS6 GSTP1 P4HB	1.19e-04	199	107	5	76b3c2ee5da8ddc214e5919b5804dfedcbb60d30
ToppCell	Bronchial-10x5prime-Stromal-Fibroblastic-Fibro_myofibroblast\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	ABCA8 SSC5D PIEZO2 FBN1 ABCA6	1.19e-04	199	107	5	21335475bbfbad8a6943b8076a6c1c67f3eec5d3
ToppCell	Caecum-B_cell-B_cell_IgA_Plasma\|Caecum / Region, Cell class and subclass	SEL1L TPST2 GAS6 GSTP1 P4HB	1.19e-04	199	107	5	49c19601566205f41f04bfb5714f865398482d39
ToppCell	wk_15-18-Mesenchymal-Fibroblast-Alveolar_fibro\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	LDOC1 ABCA8 TRIL PIEZO2 ABCA6	1.19e-04	199	107	5	6bce8e65859a35cfea1c210f9c9765952d492ed2
ToppCell	Biopsy_Other_PF-Mesenchymal-Myofibroblasts\|Biopsy_Other_PF / Sample group, Lineage and Cell type	ABCA8 SSC5D PIEZO2 FBN1 ABCA6	1.22e-04	200	107	5	e504570fd7eec1524c401b1cfa9d10822d80d994
ToppCell	Neuronal-Inhibitory-iB-iB_2(PVALB)-SULF1--L4-6\|Neuronal / cells hierarchy compared to all cells using T-Statistic	SLC35F4 PIEZO2 WNT16 CNTNAP2 ASPM	1.22e-04	200	107	5	4a426ef88376d8bb2b9dc50aa06e7b9fc50ecc9c
ToppCell	10x3'2.3-week_12-13-Mesenchymal_fibro-stroma-arteriolar_fibroblast\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	ABCA8 TRIL LRIG3 FBN1 ABCA6	1.22e-04	200	107	5	fee22a6a6c7b93af204b5b56f2c34f1411500e18
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ABCA2 TF ABCA8 PIEZO2 BOK	1.22e-04	200	107	5	acdef0b9096c774040948fc75621ff2b08ea2ee8
ToppCell	wk_20-22-Mesenchymal-Fibroblast-intermediate_fibro\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	ABCA8 PIEZO2 FBN1 ABCA6 CNTNAP2	1.22e-04	200	107	5	d769723f8fcb37d9b86589e0c41c1d7f16393cfe
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ABCA2 TF ABCA8 PIEZO2 BOK	1.22e-04	200	107	5	091a18d6efed81cab99955c3047f172170f70476
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c05-ZNF683\|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)	TPST2 RNF213 CCND3 GSTP1 NLRC5	1.22e-04	200	107	5	2bd8c35484fe6b0bc0f9314216786baaa97d1e95
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Oligodendrocyte\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ABCA2 TF ABCA8 PIEZO2 BOK	1.22e-04	200	107	5	3b8513defe25262ab4b492345b2628570eaefd17
ToppCell	Bronchial-NucSeq-Immune_Lymphocytic-T-T_CD4-CD4_naive/CM\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PBX4 CCND3 JAK3 NLRC5 VAV1	1.22e-04	200	107	5	e0cec0a844b7c1f8edee4c005af27766754e470a
ToppCell	Parenchymal-10x5prime-Stromal-Fibroblastic\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	ABCA8 SSC5D PIEZO2 FBN1 ABCA6	1.22e-04	200	107	5	6e3d1ae0ef84d3075afa40129a41169996462672
ToppCell	Lung_Parenchyma-Severe-Mesenchymal\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	ABCA8 SSC5D PIEZO2 FBN1 ABCA6	1.22e-04	200	107	5	6ce8e2cf689523993d909a27daec3d6a5824d13c
ToppCell	Lung_Parenchyma-Severe-Mesenchymal-Mesenchymal\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	ABCA8 SSC5D PIEZO2 FBN1 ABCA6	1.22e-04	200	107	5	907427e85cebe5a18c8a310e2ffa0e180ea3cb77
ToppCell	Bronchial-NucSeq-Immune_Lymphocytic-T\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PBX4 CCND3 JAK3 NLRC5 VAV1	1.22e-04	200	107	5	c6c2b39359c65c9444987d02d1c899dff2ad1366
ToppCell	Sepsis-Int-URO-Myeloid-tDC\|Int-URO / Disease, condition lineage and cell class	TRPM4 CXCR3 USE1 GAS6 PARS2	1.22e-04	200	107	5	f5d0497a72da21cad24e0ef51c3dc4d024dbf294
ToppCell	wk_20-22-Mesenchymal-Fibroblast\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	LDOC1 ABCA8 TRIL PIEZO2 ABCA6	1.22e-04	200	107	5	94bd00fb6ff0dcb668eb36ec2085f1c3128855b6
ToppCell	Neuronal-Inhibitory-iB-iB_2(PVALB)-SULF1\|Neuronal / cells hierarchy compared to all cells using T-Statistic	SLC35F4 PIEZO2 WNT16 CNTNAP2 ASPM	1.22e-04	200	107	5	fbeee1c16ac0a7fe28d90491c8b079f21ce80bdc
ToppCell	Neuronal-Inhibitory-iB-iB_2(PVALB)-SULF1-\|Neuronal / cells hierarchy compared to all cells using T-Statistic	SLC35F4 PIEZO2 WNT16 CNTNAP2 ASPM	1.22e-04	200	107	5	c6eda342ea0cb37d71d89dbb8d11e819e0745172
ToppCell	wk_15-18-Mesenchymal-Fibroblast\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	LDOC1 ABCA8 PIEZO2 ABCA6 CNTNAP2	1.22e-04	200	107	5	4f624c3c57d1a84baa86d0830cb1b83ae110bf67
ToppCell	Parenchyma_COVID-19-Stromal-TX\|Parenchyma_COVID-19 / Sample group, Lineage and Cell type	ABCA8 SSC5D PIEZO2 FBN1 ABCA6	1.22e-04	200	107	5	8472baa74c48b67c5f08223025885c833458290b
ToppCell	Parenchymal-10x5prime-Stromal-Fibroblastic-Fibro_myofibroblast\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	COL7A1 SSC5D PIEZO2 FBN1 ABCA6	1.22e-04	200	107	5	54806080b5e97859ee6a4a9b4f19e22021c218f5
ToppCell	Biopsy_IPF-Mesenchymal-Myofibroblasts\|Biopsy_IPF / Sample group, Lineage and Cell type	ABCA8 SSC5D PIEZO2 FBN1 ABCA6	1.22e-04	200	107	5	c2c6f687c49ba790174b27c7b8b084af30b34c86
ToppCell	(21)_B_cell_IgG_Plasma\|World / shred on Cell_type and subtype	SEL1L TPST2 GAS6 GSTP1 P4HB	1.30e-04	203	107	5	15055e1b1017afbdb2a567972cbb976deb7d4e6a
ToppCell	facs-Lung-Endomucin-24m-Endothelial-Artery_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HDAC6 SLC35F4 FBN2 ASPM	1.95e-04	119	107	4	c3f1223356e7f245a460ea5568a223e34e458dc1
ToppCell	3'_v3-blood-Lymphocytic_T_CD4-T_CD4/CD8\|blood / Manually curated celltypes from each tissue	RNF213 PBX4 NLRC5 HERC1	3.15e-04	135	107	4	ae2d3a42e567b5bade304c0caa497eb725be3565
ToppCell	droplet-Liver-Npc-21m\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CXCR3 PIEZO2 FBN2 PROM2	5.31e-04	155	107	4	d883a3869cf893d62741f26f641ed3923aba03f9
Drug	colchicine; Down 200; 1uM; SKMEL5; HG-U133A	TPST2 ILF3 HDAC6 THADA CLDN17 CRBN HTT PML	3.44e-06	195	105	8	630_DN
Drug	prochlorperazine dimaleate salt; Down 200; 10uM; MCF7; HT_HG-U133A	TRPM4 ABCA2 GPR27 CUL9 EXD3 SLC19A1 SLC23A2 PML	4.15e-06	200	105	8	5212_DN
Disease	Colorectal Neoplasms	COL7A1 LAMA1 ABCB6 ABCA8 FBN2 ABCA6 SLC19A1 SMAD4	6.00e-06	277	103	8	C0009404
Disease	Colorectal Carcinoma	COL7A1 LAMA1 ABCB6 PBX4 ABCA8 FBN2 NFATC1 ABCA6 SLC19A1 WNT16 CUX1 SMAD4	6.35e-06	702	103	12	C0009402
Disease	connective tissue disease (implicated_via_orthology)	FBN1 FBN2	3.61e-05	3	103	2	DOID:65 (implicated_via_orthology)
Disease	lymphocyte count	SEL1L RANBP10 AMZ1 GAS6 HECTD4 SREBF1 PBX4 NCLN ADCY5 CCND3 THADA FBN1 NFATC1 NLRC5 VAV1 HTT	4.70e-05	1464	103	16	EFO_0004587
Disease	obsolete_red blood cell distribution width	MYO19 GAS6 HECTD4 ABCB6 PBX4 HSD11B1L TF CCND3 CCNF FBN2 AP2B1 ABCA6 SLC19A1 HERC1 SLC23A2	6.75e-05	1347	103	15	EFO_0005192
Disease	scoliosis (is_implicated_in)	FBN1 FBN2	7.21e-05	4	103	2	DOID:0060249 (is_implicated_in)
Disease	Parkinson Disease	CYP2D6 SLC2A14 GSTP1 CNTNAP2	2.28e-04	85	103	4	C0030567
Disease	multiple myeloma (is_marker_for)	CCND3 GSTP1 PML	2.71e-04	36	103	3	DOID:9538 (is_marker_for)
Disease	reticulocyte count	USE1 CYP27A1 HECTD4 ABCB6 CCND3 THADA AP1B1 AP2B1 SLC19A1 HERC1 SLC23A2 CUX1	2.89e-04	1045	103	12	EFO_0007986
Disease	autosomal recessive intellectual developmental disorder (implicated_via_orthology)	CNTNAP2 CRBN	3.33e-04	8	103	2	DOID:0060308 (implicated_via_orthology)
Disease	mesangial proliferative glomerulonephritis (biomarker_via_orthology)	RAPGEF1 FBN1	3.33e-04	8	103	2	DOID:4783 (biomarker_via_orthology)
Disease	Acute kidney injury	CYP2D6 GAS6 TF GSTP1	4.41e-04	101	103	4	C2609414
Disease	Acute Kidney Insufficiency	CYP2D6 GAS6 TF GSTP1	4.41e-04	101	103	4	C1565662
Disease	Kidney Failure, Acute	CYP2D6 GAS6 TF GSTP1	4.41e-04	101	103	4	C0022660
Disease	sexual dimorphism measurement	RANBP10 COL7A1 AMZ1 ABCA8 CCND3 SSC5D FBN1 BOK COMMD4 CDK5RAP1 NLRC5 HERC1	4.81e-04	1106	103	12	EFO_0021796
Disease	apolipoprotein A 1 measurement, apolipoprotein B measurement	GAS6 ABCA8 ABCA6 NLRC5	5.48e-04	107	103	4	EFO_0004614, EFO_0004615
Disease	visual epilepsy (is_implicated_in)	CNTNAP2 ASPM	6.50e-04	11	103	2	DOID:11832 (is_implicated_in)
Disease	hepatocellular carcinoma (is_marker_for)	GSTP1 ASPM NLRC5 CUX1 SMAD4 PML	6.70e-04	301	103	6	DOID:684 (is_marker_for)
Disease	apolipoprotein B to apolipoprotein A1 ratio	ABCA8 ABCA6 NLRC5	6.77e-04	49	103	3	EFO_0021897
Disease	Huntington Disease, Late Onset	FAAH HTT	7.78e-04	12	103	2	C0393574
Disease	Akinetic-Rigid Variant of Huntington Disease	FAAH HTT	7.78e-04	12	103	2	C0751207
Disease	Juvenile Huntington Disease	FAAH HTT	7.78e-04	12	103	2	C0751208
Disease	ADHD symptom measurement	PBX4 CUX1	7.78e-04	12	103	2	EFO_0007860
Disease	Adenocarcinoma of lung (disorder)	IPO4 TF SLC19A1 TAF1L VAV1	7.95e-04	206	103	5	C0152013
Disease	Familial thoracic aortic aneurysm and aortic dissection	FBN1 FBN2 SMAD4	8.52e-04	53	103	3	C4707243
Disease	hematologic cancer (implicated_via_orthology)	JAK3 CUX1	9.18e-04	13	103	2	DOID:2531 (implicated_via_orthology)
Disease	Manganese Poisoning	CYP2D6 HTT	1.07e-03	14	103	2	C0677050
Disease	tea consumption measurement	ZNF618 HECTD4 CUL9 SLC35D3	1.10e-03	129	103	4	EFO_0010091
Disease	prostate carcinoma, type 2 diabetes mellitus	SREBF1 LMTK2 THADA	1.17e-03	59	103	3	EFO_0001663, MONDO_0005148
Disease	FEV/FEC ratio	AMZ1 RDH14 THADA FBN1 TTC7B NFATC1 SLC19A1 WNT16 CNTNAP2 HERC1 CUX1 PML	1.19e-03	1228	103	12	EFO_0004713
Disease	macrophage inflammatory protein 1b measurement	COL7A1 MYO19 LRIG3 AP2B1	1.34e-03	136	103	4	EFO_0008219
Disease	HETE measurement	ELP3 NBAS CNTNAP2	1.35e-03	62	103	3	EFO_0801166
Disease	neutrophil percentage of leukocytes	NCLN ISM2 ADCY5 THADA FBN1 NFATC1 NLRC5 HTT	1.36e-03	610	103	8	EFO_0007990
Disease	filaggrin gene expression measurement	ZNF618 SLC35F4	1.40e-03	16	103	2	EFO_0020899
Disease	pre-malignant neoplasm (biomarker_via_orthology)	GSTP1 SMAD4	1.59e-03	17	103	2	DOID:0060071 (biomarker_via_orthology)
Disease	Huntington Disease	FAAH HTT	1.59e-03	17	103	2	C0020179
Disease	MHPG measurement, 5-HIAA measurement	CCND3 PIEZO2	1.59e-03	17	103	2	EFO_0005132, EFO_0005133
Disease	physical activity measurement	ILF3 EXD3 HERC1 CUX1 PML	1.71e-03	245	103	5	EFO_0008002
Disease	non-alcoholic steatohepatitis (is_marker_for)	CYP27A1 SMAD4	1.78e-03	18	103	2	DOID:0080547 (is_marker_for)
Disease	type 2 diabetes mellitus (biomarker_via_orthology)	SREBF1 ADCY5 FBN1 SMAD4	1.78e-03	147	103	4	DOID:9352 (biomarker_via_orthology)
Disease	Non-alcoholic Fatty Liver Disease	LAMA1 SREBF1 GSTP1	1.91e-03	70	103	3	C0400966
Disease	Nonalcoholic Steatohepatitis	LAMA1 SREBF1 GSTP1	1.91e-03	70	103	3	C3241937
Disease	urinary microalbumin measurement	MON2 CNTNAP2	2.20e-03	20	103	2	EFO_0010967
Disease	very low density lipoprotein cholesterol measurement, cholesteryl esters:total lipids ratio	HECTD4 ABCA8 ABCA6 NLRC5 HTT	2.37e-03	264	103	5	EFO_0008317, EFO_0020944
Disease	kidney disease (biomarker_via_orthology)	SREBF1 NFATC1	2.43e-03	21	103	2	DOID:557 (biomarker_via_orthology)
Disease	Disease Exacerbation	RANBP10 COL7A1 GSTP1 NBAS	2.71e-03	165	103	4	C0235874
Disease	apolipoprotein A 1 measurement	COL7A1 TF ADCY5 ABCA8 CCND3 METAP1 ABCA6 NLRC5 HERC1	2.90e-03	848	103	9	EFO_0004614
Disease	unipolar depression, response to selective serotonin reuptake inhibitor	CYP2D6 CUX1	3.17e-03	24	103	2	EFO_0003761, EFO_0005658
Disease	Drug toxicity	CYP2D6 TF SLC19A1	3.21e-03	84	103	3	C0013221
Disease	Adverse reaction to drug	CYP2D6 TF SLC19A1	3.21e-03	84	103	3	C0041755
Disease	Dystonia	CYP2D6 CYP27A1 ADCY5	3.43e-03	86	103	3	C0013421

Protein segments in the cluster

Peptide	Gene	Start	Entry
LVDILMDLGALARNC	CXCR3	276	P49682
LLGAVCMLLASKLRE	CCND3	101	P30281
LIRALAVRTMGCIRV	AP2B1	101	P63010
RCLMQGALSLDEALR	AMZ1	276	Q400G9
MLCVAGARLKRELDA	CUX1	1	P39880
DRVAIMVSGRLRCIG	ABCA6	1481	Q8N139
IGSAIQRLRCELDIM	CRBN	301	Q96SW2
LICLGLMGLERALNV	ABCB6	266	Q9NP58
LIRALAVRTMGCIRV	AP1B1	101	Q10567
AAVGVILIMAVLCNR	ADCY5	276	O95622
VNVAITMCVLGLRDR	HSD11B1L	201	Q7Z5J1
VCAVLLRLGDELEMI	BOK	66	Q9UMX3
DLQCGVRLVRTMELL	ASPM	971	Q8IZT6
RALMCVAVALSLIAL	CLDN17	81	P56750
ALGQASECLRLMARA	RANBP10	591	Q6VN20
ECLSLAVLDLARMAR	JAK3	161	P52333
AAEVLSRRCVLMRLL	NCLN	76	Q969V3
RVARIMVCGRIALAK	KCTD8	231	Q6ZWB6
CLGMSEFLRALGRRV	GPN2	26	Q9H9Y4
IEGMRLVCRLAREVL	METAP1	136	P53582
LMEQLRLLVCERASL	LDOC1	26	O95751
DGCAMLLRVRASITL	IL17REL	21	Q6ZVW7
DLTIRAGAMARLECA	LRIG3	611	Q6UXM1
RIRMACLAAKELDGV	MYO19	821	Q96H55
LVRVLSAMLFLLIGC	KCNK4	166	Q9NYG8
LVRLMCLAAAGRAGL	HERC1	3221	Q15751
GRVCCEGMLIQLRFL	CCDC47	211	Q96A33
LRALACLPAVMLAAR	GPR27	66	Q9NS67
MRALRDRAGLLLCVL	ISM2	1	Q6H9L7
CRRMGVNAERSLLIL	PNMA6F	6	A0A0J9YX94
SGVLLAMALDRCVAI	OR52A4P	116	A6NMU1
IMSLVGVLRRLAACR	EEF2KMT	256	Q96G04
SMRAVIDCAGILKLR	NFATC1	526	O95644
RRAIMGFLEEILAVC	HEATR6	1151	Q6AI08
LLQRMACEVAAGLAA	LMTK2	241	Q8IWU2
MLRRALLCLAVAALV	P4HB	1	P07237
ILKAELTMAALCGRL	MON2	581	Q7Z3U7
AVMALDRAAAVCRPL	OR2I1P	116	Q8NGU4
LVRSGLVQLMDRLCS	HECTD4	1286	Q9Y4D8
VCAAALRGLSRTILM	PELP1	521	Q8IZL8
VEMLILGRLVIGLFC	SLC2A14	141	Q8TDB8
DCALSLIRLGMERNI	NBAS	861	A2RRP1
TFEECVLGLAMVRLR	PRPF39	446	Q86UA1
ESLVLCRRLEELMLG	NLRC5	1656	Q86WI3
ALRGRRLALGLCMAA	F2RL3	186	Q96RI0
LLRLDNMLLAEGVCR	PBX4	81	Q9BYU1
LGMCNREIVRRGALI	HTT	1886	P42858
DTLVRILARCDIMVL	DNASE1L1	41	P49184
RLQLLGIACMVICTR	CCNF	351	P41002
MTLDATGRICLDIRL	FBN1	941	P35555
RACLGEPLARMELFL	CYP2D6	441	P10635
RGCMTLEVNRRLLDL	GAS6	641	Q14393
CLGRRIAELEMQLLL	CYP27A1	476	Q02318
ALRRVLECLASGIVM	ILF3	271	Q12906
SSGLRGCMLIELALR	GOLPH3	86	Q9H4A6
GCMLIELALRGRLQL	GOLPH3	91	Q9H4A6
VRGRCAALRMLLADQ	GSTP1	11	P09211
LCTRLAIMVNGRLRC	ABCA2	2251	Q9BZC7
LRVCSLRMNRLAGVG	COMMD4	121	Q9H0A8
RALCRITDGTMLQAI	COPG2	126	Q9UBF2
LALARMKDLGIQCRD	ELP3	386	Q9H9T3
CMEGRVAITRVANLL	LAMTOR2	76	Q9Y2Q5
RADCLSTGMELLRRI	CUL9	2401	Q8IWT3
MTLRLLVAALCAGIL	COL7A1	1	Q02388
CIRSLRMNGVTLDLE	CNTNAP2	936	Q9UHC6
GPMARDVESLALCLR	FAAH	281	O00519
RILRIMCRLEELGLA	HDAC6	506	Q9UBN7
LTLDGTGRVCLDIRM	FBN2	986	P35556
RVRDNICGALARLLM	IPO4	956	Q8TEX9
LVLRGMDSEVLSCRI	MROH2A	1351	A6NES4
MEGLLTRCRALPALA	PARS2	1	Q7L3T8
MRQLCRGRVLGISVA	SLC35D3	1	Q5M8T2
RGALGALMACLRIAR	THADA	591	Q6YHU6
MLRKAECLVALGRLQ	SMYD4	146	Q8IYR2
MRVRIGLTLLLCAVL	SEL1L	1	Q9UBV2
ALLRAELMCTLREVR	PRAMEF14	431	Q5SWL7
MRPGCDLLLRAAATV	TAF1L	1	Q8IZX4
AVLAMRDLCRLLEVS	PML	746	P29590
MRGGVLLVLLLCVAA	LAMA1	1	P25391
GVDDLRRLCILRMSF	SMAD4	491	Q13485
AELLRLGARVIMGCR	RDH14	61	Q9HBH5
MRVLACLLAALVGIQ	SSC5D	1	A1L4H1
RLAATIIICIGFLLM	SLC35F4	456	A4IF30
GMLDRSRLALCTLVF	SREBF1	481	P36956
DRVAIMVSGRLRCIG	ABCA8	1486	O94911
CSFDVAIIAGRLRML	BCL2L15	46	Q5TBC7
LRIGILGCMAERLKE	CDK5RAP1	176	Q96SZ6
CRMIRLLSLVDSAGQ	RNF213	876	Q63HN8
LELNLVRLLSRCEAM	USE1	6	Q9NZ43
MRLSVRRVLLAAGCA	TPST2	1	O60704
ERLLRVMCADLGALS	ZNF618	471	Q5T7W0
MRLAVGALLVCAVLG	TF	1	P02787
LLMELVFRLVCNGEL	RAPGEF1	781	Q13905
RRVIQCGAALMLALG	SLC23A2	456	Q9UGH3
ALACERAALMVFLLL	PROM2	146	Q8N271
VVEMAEADLRALLCR	STOML1	351	Q9UBI4
LRLALDAMRDLAQCV	VAV1	356	P15498
MLLVALGILCAFRRL	SCTR	156	P47872
ALRVACGDSVLARML	SLC19A1	241	P41440
MEAARALRLLLVVCG	TRIL	1	Q7L0X0
MASEVVCGLIFRLLL	PIEZO2	1	Q9H5I5
MDRAALLGLARLCAL	WNT16	1	Q9UBV4
ICRRLSVVFAGMIEL	TMEM168	261	Q9H0V1
IARQLAEILLRGMCE	TTC7B	261	Q86TV6
LGRCRMALLLAVALD	TMEM238	31	C9JI98
LMLAALRTLVGICSE	UNC45A	211	Q9H3U1
VSSALGACLLLRVMA	TRPM4	586	Q8TD43
ILVLEMADQGRLLDC	TRIO	2866	O75962
LARSLRCLGVDARML	EXD3	641	Q8N9H8