Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	low-density lipoprotein particle receptor activity	LRP1 LRP2 LDLR SORL1	2.41e-09	16	23	4	GO:0005041
GeneOntologyMolecularFunction	lipoprotein particle receptor activity	LRP1 LRP2 LDLR SORL1	7.90e-09	21	23	4	GO:0030228
GeneOntologyMolecularFunction	cargo receptor activity	LRP1 LRP2 LDLR SSC5D SORL1	3.93e-08	85	23	5	GO:0038024
GeneOntologyMolecularFunction	clathrin heavy chain binding	LRP1 LDLR	8.32e-05	12	23	2	GO:0032050
GeneOntologyMolecularFunction	low-density lipoprotein particle binding	LDLR SORL1	1.92e-04	18	23	2	GO:0030169
GeneOntologyMolecularFunction	amyloid-beta binding	LRP1 LDLR SORL1	2.13e-04	102	23	3	GO:0001540
GeneOntologyMolecularFunction	scavenger receptor activity	LRP1 SSC5D	4.38e-04	27	23	2	GO:0005044
GeneOntologyMolecularFunction	laminin binding	ITGA9 SSC5D	6.96e-04	34	23	2	GO:0043236
GeneOntologyMolecularFunction	lipoprotein particle binding	LDLR SORL1	7.38e-04	35	23	2	GO:0071813
GeneOntologyMolecularFunction	protein-lipid complex binding	LDLR SORL1	7.38e-04	35	23	2	GO:0071814
GeneOntologyMolecularFunction	lipoprotein particle receptor binding	LRP1 LRP2	9.16e-04	39	23	2	GO:0070325
GeneOntologyMolecularFunction	clathrin binding	LRP1 LDLR	2.37e-03	63	23	2	GO:0030276
GeneOntologyMolecularFunction	extracellular matrix binding	ITGA9 SSC5D	3.17e-03	73	23	2	GO:0050840
GeneOntologyMolecularFunction	methylated histone binding	ATRX KDM4A	4.37e-03	86	23	2	GO:0035064
GeneOntologyMolecularFunction	methylation-dependent protein binding	ATRX KDM4A	4.57e-03	88	23	2	GO:0140034
GeneOntologyMolecularFunction	amide binding	LRP1 LDLR SORL1	4.71e-03	299	23	3	GO:0033218
GeneOntologyMolecularFunction	peptide binding	LRP1 LDLR SORL1	5.60e-03	318	23	3	GO:0042277
GeneOntologyMolecularFunction	ATP-dependent activity, acting on DNA	ATRX MCM9	9.30e-03	127	23	2	GO:0008094
GeneOntologyMolecularFunction	calcium ion binding	LRP1 LRP2 LDLR ADAMTS13	9.85e-03	749	23	4	GO:0005509
GeneOntologyBiologicalProcess	positive regulation of lysosomal protein catabolic process	LRP1 LRP2 LDLR	1.21e-08	5	23	3	GO:1905167
GeneOntologyBiologicalProcess	positive regulation of protein catabolic process in the vacuole	LRP1 LRP2 LDLR	4.23e-08	7	23	3	GO:1904352
GeneOntologyBiologicalProcess	regulation of nervous system development	LRP1 LRP2 EIF2AK3 LDLR LIMK1 KDM4A TENM4 SORL1	2.23e-07	625	23	8	GO:0051960
GeneOntologyBiologicalProcess	regulation of lysosomal protein catabolic process	LRP1 LRP2 LDLR	2.65e-07	12	23	3	GO:1905165
GeneOntologyBiologicalProcess	regulation of protein catabolic process in the vacuole	LRP1 LRP2 LDLR	4.37e-07	14	23	3	GO:1904350
GeneOntologyBiologicalProcess	regulation of neurogenesis	LRP1 LRP2 LDLR LIMK1 KDM4A TENM4 SORL1	1.01e-06	515	23	7	GO:0050767
GeneOntologyBiologicalProcess	lysosomal protein catabolic process	LRP1 LRP2 LDLR	2.41e-06	24	23	3	GO:1905146
GeneOntologyBiologicalProcess	protein catabolic process in the vacuole	LRP1 LRP2 LDLR	3.90e-06	28	23	3	GO:0007039
GeneOntologyBiologicalProcess	positive regulation of protein catabolic process	LRP1 LRP2 EIF2AK3 LDLR SORL1	4.52e-06	228	23	5	GO:0045732
GeneOntologyBiologicalProcess	amyloid-beta clearance	LRP1 LRP2 LDLR	1.16e-05	40	23	3	GO:0097242
GeneOntologyBiologicalProcess	chemoattraction of axon	LRP1 LRP2	1.19e-05	5	23	2	GO:0061642
GeneOntologyBiologicalProcess	regulation of gliogenesis	LRP2 LDLR KDM4A TENM4	2.19e-05	151	23	4	GO:0014013
GeneOntologyBiologicalProcess	amyloid-beta clearance by cellular catabolic process	LRP1 LDLR	3.32e-05	8	23	2	GO:0150094
GeneOntologyBiologicalProcess	regulation of protein catabolic process	LRP1 LRP2 EIF2AK3 LDLR SORL1	7.33e-05	407	23	5	GO:0042176
GeneOntologyBiologicalProcess	gliogenesis	LRP1 LRP2 LDLR KDM4A TENM4	1.00e-04	435	23	5	GO:0042063
GeneOntologyBiologicalProcess	regulation of triglyceride catabolic process	LDLR SORL1	1.24e-04	15	23	2	GO:0010896
GeneOntologyBiologicalProcess	regulation of cell development	LRP1 LRP2 LDLR LIMK1 KDM4A TENM4 SORL1	1.35e-04	1095	23	7	GO:0060284
GeneOntologyBiologicalProcess	cholesterol import	LRP1 LDLR	1.41e-04	16	23	2	GO:0070508
GeneOntologyBiologicalProcess	artery morphogenesis	LRP1 LRP2 LDLR	1.43e-04	92	23	3	GO:0048844
GeneOntologyBiologicalProcess	regulation of glial cell differentiation	LDLR KDM4A TENM4	2.05e-04	104	23	3	GO:0045685
GeneOntologyBiologicalProcess	astrocyte differentiation	LRP1 LDLR KDM4A	2.11e-04	105	23	3	GO:0048708
GeneOntologyBiologicalProcess	negative regulation of astrocyte differentiation	LDLR KDM4A	2.71e-04	22	23	2	GO:0048712
GeneOntologyBiologicalProcess	transcytosis	LRP1 LRP2	3.23e-04	24	23	2	GO:0045056
GeneOntologyBiologicalProcess	glial cell differentiation	LRP1 LDLR KDM4A TENM4	4.04e-04	321	23	4	GO:0010001
GeneOntologyBiologicalProcess	artery development	LRP1 LRP2 LDLR	4.22e-04	133	23	3	GO:0060840
GeneOntologyBiologicalProcess	lipoprotein transport	LRP1 LRP2	4.42e-04	28	23	2	GO:0042953
GeneOntologyBiologicalProcess	lipoprotein localization	LRP1 LRP2	4.74e-04	29	23	2	GO:0044872
GeneOntologyBiologicalProcess	astrocyte activation	LRP1 LDLR	4.74e-04	29	23	2	GO:0048143
GeneOntologyBiologicalProcess	receptor-mediated endocytosis	LRP1 LRP2 LDLR SORL1	4.85e-04	337	23	4	GO:0006898
GeneOntologyBiologicalProcess	triglyceride catabolic process	LDLR SORL1	5.08e-04	30	23	2	GO:0019433
GeneOntologyBiologicalProcess	positive regulation of neurogenesis	LRP1 LRP2 LIMK1 TENM4	5.83e-04	354	23	4	GO:0050769
GeneOntologyBiologicalProcess	glial cell development	LRP1 LDLR TENM4	6.85e-04	157	23	3	GO:0021782
GeneOntologyBiologicalProcess	negative regulation of glial cell differentiation	LDLR KDM4A	8.60e-04	39	23	2	GO:0045686
GeneOntologyBiologicalProcess	negative regulation of multicellular organismal process	ITGA9 EIF2AK3 LDLR SSC5D TLR8 KDM4A SORL1	8.79e-04	1488	23	7	GO:0051241
GeneOntologyBiologicalProcess	positive regulation of catabolic process	LRP1 LRP2 EIF2AK3 LDLR SORL1	9.04e-04	701	23	5	GO:0009896
GeneOntologyBiologicalProcess	negative regulation of neurogenesis	LDLR KDM4A SORL1	9.08e-04	173	23	3	GO:0050768
GeneOntologyBiologicalProcess	neutral lipid catabolic process	LDLR SORL1	9.50e-04	41	23	2	GO:0046461
GeneOntologyBiologicalProcess	acylglycerol catabolic process	LDLR SORL1	9.50e-04	41	23	2	GO:0046464
GeneOntologyBiologicalProcess	negative regulation of protein metabolic process	LRP1 EIF2AK3 LDLR LIMK1 HEXIM2 SORL1	9.88e-04	1088	23	6	GO:0051248
GeneOntologyBiologicalProcess	regulation of astrocyte differentiation	LDLR KDM4A	1.04e-03	43	23	2	GO:0048710
GeneOntologyBiologicalProcess	negative regulation of nervous system development	LDLR KDM4A SORL1	1.08e-03	184	23	3	GO:0051961
GeneOntologyBiologicalProcess	positive regulation of nervous system development	LRP1 LRP2 LIMK1 TENM4	1.08e-03	418	23	4	GO:0051962
GeneOntologyBiologicalProcess	protein catabolic process	LRP1 LRP2 EIF2AK3 LDLR ADAMTS13 SORL1	1.12e-03	1115	23	6	GO:0030163
GeneOntologyBiologicalProcess	astrocyte development	LRP1 LDLR	1.25e-03	47	23	2	GO:0014002
GeneOntologyBiologicalProcess	central nervous system development	ATRX LRP1 LRP2 LDLR KDM4A TENM4	1.62e-03	1197	23	6	GO:0007417
GeneOntologyBiologicalProcess	positive regulation of axon extension	LRP1 LIMK1	1.70e-03	55	23	2	GO:0045773
GeneOntologyBiologicalProcess	receptor recycling	LDLR SORL1	1.70e-03	55	23	2	GO:0001881
GeneOntologyBiologicalProcess	negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	LRP1 LRP2 SORL1	1.76e-03	218	23	3	GO:0090101
GeneOntologyBiologicalProcess	endocytosis	LRP1 LRP2 LDLR LIMK1 SORL1	1.89e-03	827	23	5	GO:0006897
GeneOntologyBiologicalProcess	regulation of triglyceride metabolic process	LDLR SORL1	1.89e-03	58	23	2	GO:0090207
GeneOntologyBiologicalProcess	DNA-templated DNA replication maintenance of fidelity	ATRX MCM9	2.02e-03	60	23	2	GO:0045005
GeneOntologyBiologicalProcess	regulation of catabolic process	LRP1 LRP2 EIF2AK3 LDLR KDM4A SORL1	2.04e-03	1252	23	6	GO:0009894
GeneOntologyBiologicalProcess	negative regulation of gliogenesis	LDLR KDM4A	2.16e-03	62	23	2	GO:0014014
GeneOntologyBiologicalProcess	response to nitrogen compound	ATRX LRP1 EIF2AK3 LDLR ADAMTS13 SORL1	2.21e-03	1272	23	6	GO:1901698
GeneOntologyBiologicalProcess	regulation of myelination	EIF2AK3 TENM4	2.52e-03	67	23	2	GO:0031641
GeneOntologyBiologicalProcess	glycerolipid catabolic process	LDLR SORL1	2.74e-03	70	23	2	GO:0046503
GeneOntologyBiologicalProcess	glial cell activation	LRP1 LDLR	2.74e-03	70	23	2	GO:0061900
GeneOntologyBiologicalProcess	positive chemotaxis	LRP1 LRP2	3.14e-03	75	23	2	GO:0050918
GeneOntologyBiologicalProcess	cell-matrix adhesion	ITGA9 LRP1 ADAMTS13	3.24e-03	270	23	3	GO:0007160
GeneOntologyBiologicalProcess	response to nutrient levels	EIF2AK3 LDLR KDM4A SORL1	3.28e-03	566	23	4	GO:0031667
GeneOntologyBiologicalProcess	phagocytosis	LRP1 LDLR LIMK1	3.37e-03	274	23	3	GO:0006909
GeneOntologyBiologicalProcess	regulation of lipid catabolic process	LDLR SORL1	3.39e-03	78	23	2	GO:0050994
GeneOntologyBiologicalProcess	negative regulation of BMP signaling pathway	LRP2 SORL1	3.57e-03	80	23	2	GO:0030514
GeneOntologyBiologicalProcess	aorta development	LRP1 LRP2	3.57e-03	80	23	2	GO:0035904
GeneOntologyBiologicalProcess	positive regulation of cytokine production	LRP1 EIF2AK3 TLR8 SORL1	3.72e-03	586	23	4	GO:0001819
GeneOntologyBiologicalProcess	receptor metabolic process	LDLR SORL1	3.74e-03	82	23	2	GO:0043112
GeneOntologyBiologicalProcess	positive regulation of protein localization	LRP1 LRP2 EIF2AK3 SORL1	3.83e-03	591	23	4	GO:1903829
GeneOntologyBiologicalProcess	coronary vasculature development	LRP1 LRP2	3.83e-03	83	23	2	GO:0060976
GeneOntologyCellularComponent	axonal growth cone	LRP1 LRP2 LIMK1	1.40e-05	45	22	3	GO:0044295
GeneOntologyCellularComponent	clathrin-coated pit	LRP1 LRP2 LDLR	7.89e-05	80	22	3	GO:0005905
GeneOntologyCellularComponent	cell surface	ITGA9 LRP1 LRP2 LDLR TLR8 ADAMTS13 SORL1	9.90e-05	1111	22	7	GO:0009986
GeneOntologyCellularComponent	external side of plasma membrane	ITGA9 LRP1 LRP2 LDLR TLR8	1.72e-04	519	22	5	GO:0009897
GeneOntologyCellularComponent	endolysosome membrane	LDLR TLR8	1.99e-04	20	22	2	GO:0036020
GeneOntologyCellularComponent	endolysosome	LDLR TLR8	4.52e-04	30	22	2	GO:0036019
GeneOntologyCellularComponent	pericentric heterochromatin	ATRX KDM4A	5.14e-04	32	22	2	GO:0005721
GeneOntologyCellularComponent	lysosomal membrane	LRP1 LRP2 LDLR TLR8	1.26e-03	462	22	4	GO:0005765
GeneOntologyCellularComponent	lytic vacuole membrane	LRP1 LRP2 LDLR TLR8	1.26e-03	462	22	4	GO:0098852
GeneOntologyCellularComponent	endocytic vesicle membrane	LRP1 LRP2 LDLR	1.37e-03	212	22	3	GO:0030666
GeneOntologyCellularComponent	vacuolar membrane	LRP1 LRP2 LDLR TLR8	1.77e-03	507	22	4	GO:0005774
GeneOntologyCellularComponent	side of membrane	ITGA9 LRP1 LRP2 LDLR TLR8	1.85e-03	875	22	5	GO:0098552
GeneOntologyCellularComponent	clathrin-coated vesicle	LRP1 LRP2 LDLR	1.89e-03	237	22	3	GO:0030136
GeneOntologyCellularComponent	growth cone	LRP1 LRP2 LIMK1	2.08e-03	245	22	3	GO:0030426
GeneOntologyCellularComponent	site of polarized growth	LRP1 LRP2 LIMK1	2.28e-03	253	22	3	GO:0030427
GeneOntologyCellularComponent	receptor complex	ITGA9 LRP1 LRP2 LDLR	2.90e-03	581	22	4	GO:0043235
GeneOntologyCellularComponent	clathrin-coated endocytic vesicle membrane	LRP2 LDLR	3.10e-03	79	22	2	GO:0030669
GeneOntologyCellularComponent	apical part of cell	MFRP LRP1 LRP2 LDLR	3.10e-03	592	22	4	GO:0045177
GeneOntologyCellularComponent	clathrin-coated endocytic vesicle	LRP2 LDLR	5.01e-03	101	22	2	GO:0045334
GeneOntologyCellularComponent	heterochromatin	ATRX KDM4A	5.01e-03	101	22	2	GO:0000792
GeneOntologyCellularComponent	basal plasma membrane	ITGA9 LRP1 LDLR	5.84e-03	354	22	3	GO:0009925
GeneOntologyCellularComponent	coated vesicle	LRP1 LRP2 LDLR	6.12e-03	360	22	3	GO:0030135
GeneOntologyCellularComponent	recycling endosome membrane	LDLR SORL1	6.13e-03	112	22	2	GO:0055038
GeneOntologyCellularComponent	endosome	LRP1 LRP2 LDLR TLR8 SORL1	6.38e-03	1167	22	5	GO:0005768
GeneOntologyCellularComponent	basal part of cell	ITGA9 LRP1 LDLR	7.00e-03	378	22	3	GO:0045178
GeneOntologyCellularComponent	endocytic vesicle	LRP1 LRP2 LDLR	7.31e-03	384	22	3	GO:0030139
GeneOntologyCellularComponent	somatodendritic compartment	LRP1 KCNN1 LRP2 LDLR SORL1	7.90e-03	1228	22	5	GO:0036477
GeneOntologyCellularComponent	lysosome	LRP1 LRP2 LDLR TLR8	9.42e-03	811	22	4	GO:0005764
GeneOntologyCellularComponent	lytic vacuole	LRP1 LRP2 LDLR TLR8	9.42e-03	811	22	4	GO:0000323
GeneOntologyCellularComponent	cytoplasmic vesicle membrane	LRP1 LRP2 LDLR TLR8 SORL1	1.02e-02	1307	22	5	GO:0030659
GeneOntologyCellularComponent	distal axon	LRP1 LRP2 LIMK1	1.03e-02	435	22	3	GO:0150034
GeneOntologyCellularComponent	clathrin-coated vesicle membrane	LRP2 LDLR	1.03e-02	147	22	2	GO:0030665
GeneOntologyCellularComponent	vesicle membrane	LRP1 LRP2 LDLR TLR8 SORL1	1.08e-02	1325	22	5	GO:0012506
GeneOntologyCellularComponent	early endosome	LRP1 LDLR SORL1	1.35e-02	481	22	3	GO:0005769
GeneOntologyCellularComponent	vacuole	LRP1 LRP2 LDLR TLR8	1.41e-02	913	22	4	GO:0005773
Domain	-	LRP1 LRP2 LDLR TENM4 SORL1	7.81e-10	39	22	5	2.120.10.30
Domain	LDLR_class-A_CS	MFRP LRP1 LRP2 LDLR SORL1	8.91e-10	40	22	5	IPR023415
Domain	Ldl_recept_b	LRP1 LRP2 LDLR SORL1	1.43e-09	14	22	4	PF00058
Domain	LDLRB	LRP1 LRP2 LDLR SORL1	1.43e-09	14	22	4	PS51120
Domain	Ldl_recept_a	MFRP LRP1 LRP2 LDLR SORL1	1.65e-09	45	22	5	PF00057
Domain	-	MFRP LRP1 LRP2 LDLR SORL1	1.85e-09	46	22	5	4.10.400.10
Domain	6-blade_b-propeller_TolB-like	LRP1 LRP2 LDLR TENM4 SORL1	1.85e-09	46	22	5	IPR011042
Domain	LY	LRP1 LRP2 LDLR SORL1	1.95e-09	15	22	4	SM00135
Domain	LDLR_classB_rpt	LRP1 LRP2 LDLR SORL1	1.95e-09	15	22	4	IPR000033
Domain	LDLRA_1	MFRP LRP1 LRP2 LDLR SORL1	2.31e-09	48	22	5	PS01209
Domain	LDrepeatLR_classA_rpt	MFRP LRP1 LRP2 LDLR SORL1	2.57e-09	49	22	5	IPR002172
Domain	LDLa	MFRP LRP1 LRP2 LDLR SORL1	2.57e-09	49	22	5	SM00192
Domain	LDLRA_2	MFRP LRP1 LRP2 LDLR SORL1	2.57e-09	49	22	5	PS50068
Domain	EGF_3	LRP1 LRP2 LDLR TENM4 SORL1	6.68e-06	235	22	5	PS50026
Domain	EGF	LRP1 LRP2 LDLR TENM4 SORL1	6.68e-06	235	22	5	SM00181
Domain	EGF-like_dom	LRP1 LRP2 LDLR TENM4 SORL1	8.85e-06	249	22	5	IPR000742
Domain	EGF-like_CS	LRP1 LRP2 LDLR TENM4 SORL1	1.11e-05	261	22	5	IPR013032
Domain	EGF_2	LRP1 LRP2 LDLR TENM4 SORL1	1.20e-05	265	22	5	PS01186
Domain	EGF_CA	LRP1 LRP2 LDLR	1.36e-04	86	22	3	PF07645
Domain	EGF_Ca-bd_CS	LRP1 LRP2 LDLR	1.95e-04	97	22	3	IPR018097
Domain	EGF_1	LRP1 LRP2 LDLR TENM4	2.05e-04	255	22	4	PS00022
Domain	EGF_CA	LRP1 LRP2 LDLR	2.07e-04	99	22	3	PS01187
Domain	ASX_HYDROXYL	LRP1 LRP2 LDLR	2.13e-04	100	22	3	PS00010
Domain	EGF-type_Asp/Asn_hydroxyl_site	LRP1 LRP2 LDLR	2.53e-04	106	22	3	IPR000152
Domain	EGF_CA	LRP1 LRP2 LDLR	3.82e-04	122	22	3	SM00179
Domain	EGF-like_Ca-bd_dom	LRP1 LRP2 LDLR	4.01e-04	124	22	3	IPR001881
Domain	cEGF	LRP1 LRP2	4.23e-04	26	22	2	IPR026823
Domain	cEGF	LRP1 LRP2	4.23e-04	26	22	2	PF12662
Domain	Growth_fac_rcpt_	LRP1 LRP2 LDLR	7.83e-04	156	22	3	IPR009030
Domain	CUB	MFRP ADAMTS13	1.76e-03	53	22	2	PS01180
Domain	CUB_dom	MFRP ADAMTS13	2.03e-03	57	22	2	IPR000859
Domain	EGF_extracell	LRP2 TENM4	2.25e-03	60	22	2	IPR013111
Domain	EGF_2	LRP2 TENM4	2.25e-03	60	22	2	PF07974
Domain	ZF_PHD_2	ATRX KDM4A	5.53e-03	95	22	2	PS50016
Domain	ZF_PHD_1	ATRX KDM4A	5.65e-03	96	22	2	PS01359
Domain	EGF	LRP1 LRP2	9.55e-03	126	22	2	PF00008
Domain	Znf_FYVE_PHD	ATRX KDM4A	1.28e-02	147	22	2	IPR011011
Pathway	REACTOME_METABOLISM_OF_FAT_SOLUBLE_VITAMINS	LRP1 LRP2 LDLR	1.64e-05	48	15	3	M27642
Pathway	WP_FATTY_ACIDS_AND_LIPOPROTEINS_TRANSPORT_IN_HEPATOCYTES	LRP1 LRP2 LDLR SSC5D SORL1	3.37e-05	381	15	5	M48063
Pathway	WP_FAMILIAL_HYPERLIPIDEMIA_TYPE_3	LRP1 LDLR	8.19e-05	13	15	2	M42551
Pathway	WP_FAMILIAL_HYPERLIPIDEMIA_TYPE_5	LRP1 LDLR	1.10e-04	15	15	2	M42552
Pathway	REACTOME_VISUAL_PHOTOTRANSDUCTION	LRP1 LRP2 LDLR	1.48e-04	100	15	3	M27158
Pathway	WP_FAMILIAL_HYPERLIPIDEMIA_TYPE_1	LRP1 LDLR	1.60e-04	18	15	2	M42559
Pathway	WP_STATIN_PATHWAY	LRP1 LDLR	1.79e-04	19	15	2	MM15868
Pathway	WP_FAMILIAL_HYPERLIPIDEMIA_TYPE_4	LRP1 LDLR	2.41e-04	22	15	2	M42574
Pathway	WP_STATIN_INHIBITION_OF_CHOLESTEROL_PRODUCTION	LRP1 LDLR	4.83e-04	31	15	2	M39514
Pathway	REACTOME_METABOLISM_OF_FAT_SOLUBLE_VITAMINS	LRP1 LRP2	1.02e-03	45	15	2	MM15344
Pathway	REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS	LRP1 LRP2 LDLR	1.10e-03	198	15	3	M18311
Pathway	WP_VITAMIN_B12_METABOLISM	LRP2 LDLR	1.46e-03	54	15	2	M39337
Pubmed	Interaction of the apolipoprotein E receptors low density lipoprotein receptor-related protein and sorLA/LR11.	LRP1 LRP2 SORL1	2.52e-09	5	23	3	19047013
Pubmed	Interaction of coagulation factor VIII with members of the low-density lipoprotein receptor family follows common mechanism and involves consensus residues within the A2 binding site 484-509.	LRP1 LRP2 LDLR	2.52e-09	5	23	3	18685438
Pubmed	Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein.	LRP1 LRP2 LDLR	5.05e-09	6	23	3	9837937
Pubmed	The PX-domain protein SNX17 interacts with members of the LDL receptor family and modulates endocytosis of the LDL receptor.	LRP1 LRP2 LDLR	8.83e-09	7	23	3	12169628
Pubmed	Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance.	LRP1 LDLR SORL1	2.12e-08	9	23	3	20005821
Pubmed	Stage-specific association of apolipoprotein A-I and E in developing mouse retina.	LRP1 LRP2 LDLR	9.15e-08	14	23	3	17389516
Pubmed	Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction.	LRP1 LRP2 LDLR	2.05e-07	18	23	3	10827173
Pubmed	MESD is essential for apical localization of megalin/LRP2 in the visceral endoderm.	LRP1 LRP2 LDLR	3.33e-07	21	23	3	21337463
Pubmed	LRP1 functions as an atheroprotective integrator of TGFbeta and PDFG signals in the vascular wall: implications for Marfan syndrome.	LRP1 LDLR	4.18e-07	2	23	2	17505534
Pubmed	Endocytic Protein Defects in the Neural Crest Cell Lineage and Its Pathway Are Associated with Congenital Heart Defects.	LRP1 LRP2	4.18e-07	2	23	2	34445520
Pubmed	Low density lipoprotein receptor-related protein polymorphisms are not risk factors for venous thromboembolism.	LRP1 LDLR	4.18e-07	2	23	2	17889283
Pubmed	Upregulation of hepatic LDL transport by n-3 fatty acids in LDL receptor knockout mice.	LRP1 LDLR	4.18e-07	2	23	2	11971949
Pubmed	LRP: role in vascular wall integrity and protection from atherosclerosis.	LRP1 LDLR	4.18e-07	2	23	2	12690199
Pubmed	An extrahepatic receptor-associated protein-sensitive mechanism is involved in the metabolism of triglyceride-rich lipoproteins.	LRP1 LDLR	4.18e-07	2	23	2	10575007
Pubmed	LDL-receptor mRNA expression in men is downregulated within an hour of an acute fat load and is influenced by genetic polymorphism.	LRP1 LDLR	4.18e-07	2	23	2	17709443
Pubmed	Inducible inactivation of hepatic LRP gene by cre-mediated recombination confirms role of LRP in clearance of chylomicron remnants.	LRP1 LDLR	4.18e-07	2	23	2	9449704
Pubmed	Hematopoietic stem/progenitor cells directly contribute to arteriosclerotic progression via integrin β2.	LRP1 LDLR	1.25e-06	3	23	2	25546260
Pubmed	Hepatic remnant lipoprotein clearance by heparan sulfate proteoglycans and low-density lipoprotein receptors depend on dietary conditions in mice.	LRP1 LDLR	1.25e-06	3	23	2	23846497
Pubmed	Inactivation of the LRP1 intracellular NPxYxxL motif in LDLR-deficient mice enhances postprandial dyslipidemia and atherosclerosis.	LRP1 LDLR	1.25e-06	3	23	2	19667105
Pubmed	Low-density lipoprotein receptor-related protein 1 prevents early atherosclerosis by limiting lesional apoptosis and inflammatory Ly-6Chigh monocytosis: evidence that the effects are not apolipoprotein E dependent.	LRP1 LDLR	1.25e-06	3	23	2	21730304
Pubmed	LRP1 controls intracellular cholesterol storage and fatty acid synthesis through modulation of Wnt signaling.	LRP1 LDLR	1.25e-06	3	23	2	18990694
Pubmed	Deletion of macrophage LDL receptor-related protein increases atherogenesis in the mouse.	LRP1 LDLR	1.25e-06	3	23	2	17303763
Pubmed	The hepatic uptake of VLDL in lrp-ldlr-/-vldlr-/- mice is regulated by LPL activity and involves proteoglycans and SR-BI.	LRP1 LDLR	1.25e-06	3	23	2	18367731
Pubmed	The adaptor protein PID1 regulates receptor-dependent endocytosis of postprandial triglyceride-rich lipoproteins.	LRP1 LDLR	1.25e-06	3	23	2	30100244
Pubmed	RAGE, LDL receptor, and LRP1 expression in the brains of SAMP8.	LRP1 LDLR	1.25e-06	3	23	2	19539695
Pubmed	Proprotein convertase subtilisin/kexin type 9 (PCSK9) can mediate degradation of the low density lipoprotein receptor-related protein 1 (LRP-1).	LRP1 LDLR	1.25e-06	3	23	2	23675525
Pubmed	Hepatic low-density lipoprotein receptor-related protein deficiency in mice increases atherosclerosis independent of plasma cholesterol.	LRP1 LDLR	1.25e-06	3	23	2	14739216
Pubmed	Dimerization leads to changes in APP (amyloid precursor protein) trafficking mediated by LRP1 and SorLA.	LRP1 SORL1	1.25e-06	3	23	2	28799085
Pubmed	Angiotensinogen and Megalin Interactions Contribute to Atherosclerosis-Brief Report.	LRP2 LDLR	1.25e-06	3	23	2	30567480
Pubmed	LDL Receptor-Related Protein-1 (LRP1) Regulates Cholesterol Accumulation in Macrophages.	LRP1 LDLR	1.25e-06	3	23	2	26061292
Pubmed	LDL receptor-related protein internalizes and degrades uPA-PAI-1 complexes and is essential for embryo implantation.	LRP1 LDLR	1.25e-06	3	23	2	1423604
Pubmed	LRP1 regulates architecture of the vascular wall by controlling PDGFRbeta-dependent phosphatidylinositol 3-kinase activation.	LRP1 LDLR	1.25e-06	3	23	2	19742316
Pubmed	The P2Y2 receptor mediates uptake of matrix-retained and aggregated low density lipoprotein in primary vascular smooth muscle cells.	LRP1 LDLR	2.51e-06	4	23	2	27522265
Pubmed	Macrophage LRP1 suppresses neo-intima formation during vascular remodeling by modulating the TGF-β signaling pathway.	LRP1 LDLR	2.51e-06	4	23	2	22174911
Pubmed	Apolipoprotein E isoform-specific effects on lipoprotein receptor processing.	LRP1 LDLR	2.51e-06	4	23	2	25015123
Pubmed	Disabled-2 is essential for endodermal cell positioning and structure formation during mouse embryogenesis.	LRP1 LRP2	2.51e-06	4	23	2	12413896
Pubmed	Murine low-density lipoprotein receptor-related protein 1 (LRP) is required for phagocytosis of targets bearing LRP ligands but is not required for C1q-triggered enhancement of phagocytosis.	LRP1 LDLR	2.51e-06	4	23	2	18566402
Pubmed	Apolipoprotein E/Amyloid-β Complex Accumulates in Alzheimer Disease Cortical Synapses via Apolipoprotein E Receptors and Is Enhanced by APOE4.	LRP1 LDLR	2.51e-06	4	23	2	31108099
Pubmed	Loss of Macrophage Low-Density Lipoprotein Receptor-Related Protein 1 Confers Resistance to the Antiatherogenic Effects of Tumor Necrosis Factor-α Inhibition.	LRP1 LDLR	2.51e-06	4	23	2	27365402
Pubmed	Macrophage low-density lipoprotein receptor-related protein deficiency enhances atherosclerosis in ApoE/LDLR double knockout mice.	LRP1 LDLR	2.51e-06	4	23	2	17038633
Pubmed	Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice.	LRP1 LDLR	2.51e-06	4	23	2	17080197
Pubmed	Decoding of lipoprotein-receptor interactions: properties of ligand binding modules governing interactions with apolipoprotein E.	LRP1 LDLR	2.51e-06	4	23	2	20030366
Pubmed	Identification of the low density lipoprotein receptor-related protein (LRP) as an endocytic receptor for thrombospondin-1.	LRP1 LRP2	2.51e-06	4	23	2	7775583
Pubmed	Developmental regulation of LR11 expression in murine brain.	LDLR SORL1	2.51e-06	4	23	2	9726247
Pubmed	Role of apolipoprotein E receptors in regulating the differential in vivo neurotrophic effects of apolipoprotein E.	LRP1 LRP2	2.51e-06	4	23	2	11421580
Pubmed	The apoE isoform binding properties of the VLDL receptor reveal marked differences from LRP and the LDL receptor.	LRP1 LDLR	2.51e-06	4	23	2	15863833
Pubmed	Brown adipose tissue activity controls triglyceride clearance.	LRP1 LDLR	2.51e-06	4	23	2	21258337
Pubmed	Opposing effects of apolipoprotein m on catabolism of apolipoprotein B-containing lipoproteins and atherosclerosis.	LRP1 LDLR	2.51e-06	4	23	2	20360257
Pubmed	LRP1 controls cPLA2 phosphorylation, ABCA1 expression and cellular cholesterol export.	LRP1 LDLR	2.51e-06	4	23	2	19718435
Pubmed	Lipoprotein clearance mechanisms in LDL receptor-deficient "Apo-B48-only" and "Apo-B100-only" mice.	LRP1 LDLR	2.51e-06	4	23	2	9788969
Pubmed	The pro-neurotrophin receptor sortilin is a major neuronal apolipoprotein E receptor for catabolism of amyloid-β peptide in the brain.	LRP1 SORL1	2.51e-06	4	23	2	23283348
Pubmed	LDL receptor cooperates with LDL receptor-related protein in regulating plasma levels of coagulation factor VIII in vivo.	LRP1 LDLR	2.51e-06	4	23	2	15840700
Pubmed	TGFβ attenuates cartilage extracellular matrix degradation via enhancing FBXO6-mediated MMP14 ubiquitination.	LRP1 LDLR TENM4 SORL1	3.94e-06	164	23	4	32409323
Pubmed	Chromosomal organization of candidate genes involved in cholesterol gallstone formation: a murine gallstone map.	LRP1 LRP2 LDLR	4.02e-06	47	23	3	11208732
Pubmed	Cholesteryl ester transfer protein (CETP) expression enhances HDL cholesteryl ester liver delivery, which is independent of scavenger receptor BI, LDL receptor related protein and possibly LDL receptor.	LRP1 LDLR	4.18e-06	5	23	2	17055779
Pubmed	Cloning of a complementary deoxyribonucleic acid encoding the murine homolog of the very low density lipoprotein/apolipoprotein-E receptor: expression pattern and assignment of the gene to mouse chromosome 19.	LRP1 LDLR	4.18e-06	5	23	2	8013374
Pubmed	ApoER2 is endocytosed by a clathrin-mediated process involving the adaptor protein Dab2 independent of its Rafts' association.	LRP1 LRP2	4.18e-06	5	23	2	16101684
Pubmed	Apolipoprotein A-V interaction with members of the low density lipoprotein receptor gene family.	LRP1 SORL1	4.18e-06	5	23	2	17326667
Pubmed	Critical Role of SREBP-1c Large-VLDL Pathway in Environment-Induced Hypertriglyceridemia of Apo AV Deficiency.	LRP1 LDLR	4.18e-06	5	23	2	30700132
Pubmed	Cold-induced conversion of cholesterol to bile acids in mice shapes the gut microbiome and promotes adaptive thermogenesis.	LRP1 LDLR	4.18e-06	5	23	2	28604703
Pubmed	Effects of six APOA5 variants, identified in patients with severe hypertriglyceridemia, on in vitro lipoprotein lipase activity and receptor binding.	LRP1 LDLR	4.18e-06	5	23	2	18635818
Pubmed	Uptake of HIV-1 tat protein mediated by low-density lipoprotein receptor-related protein disrupts the neuronal metabolic balance of the receptor ligands.	LRP1 LDLR	4.18e-06	5	23	2	11100124
Pubmed	The nuclear hormone receptor PPARγ counteracts vascular calcification by inhibiting Wnt5a signalling in vascular smooth muscle cells.	LRP1 LDLR	4.18e-06	5	23	2	23011131
Pubmed	Normal sorting but defective endocytosis of the low density lipoprotein receptor in mice with autosomal recessive hypercholesterolemia.	LRP1 LDLR	4.18e-06	5	23	2	12746448
Pubmed	Apolipoprotein CI inhibits scavenger receptor BI and increases plasma HDL levels in vivo.	LRP1 LDLR	4.18e-06	5	23	2	18992221
Pubmed	Low levels of copper disrupt brain amyloid-β homeostasis by altering its production and clearance.	LRP1 LDLR	4.18e-06	5	23	2	23959870
Pubmed	Low-density lipoprotein receptor represents an apolipoprotein E-independent pathway of Aβ uptake and degradation by astrocytes.	LRP1 LDLR	6.26e-06	6	23	2	22383525
Pubmed	The low-density lipoprotein receptor-related protein 1 mediates tissue-type plasminogen activator-induced microglial activation in the ischemic brain.	LRP1 LDLR	6.26e-06	6	23	2	19147818
Pubmed	ApoC-III inhibits clearance of triglyceride-rich lipoproteins through LDL family receptors.	LRP1 LDLR	6.26e-06	6	23	2	27400128
Pubmed	Apolipoprotein CI causes hypertriglyceridemia independent of the very-low-density lipoprotein receptor and apolipoprotein CIII in mice.	LRP1 LDLR	6.26e-06	6	23	2	16478678
Pubmed	LRP1 Deficiency in Vascular SMC Leads to Pulmonary Arterial Hypertension That Is Reversed by PPARγ Activation.	LRP1 LDLR	6.26e-06	6	23	2	31023188
Pubmed	Inactivation of ANGPTL3 reduces hepatic VLDL-triglyceride secretion.	LRP1 LDLR	6.26e-06	6	23	2	25954050
Pubmed	Embryo implantation in mouse: fetomaternal coordination in the pattern of expression of uPA, uPAR, PAI-1 and alpha 2MR/LRP genes.	LRP1 LDLR	8.77e-06	7	23	2	8798151
Pubmed	Expression of mouse alpha-macroglobulins, lipoprotein receptor-related protein, LDL receptor, apolipoprotein E, and lipoprotein lipase in pregnancy.	LRP1 LDLR	8.77e-06	7	23	2	7595098
Pubmed	Apolipoproteins E and AV mediate lipoprotein clearance by hepatic proteoglycans.	LRP1 LDLR	8.77e-06	7	23	2	23676495
Pubmed	Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2.	LRP1 LDLR	1.17e-05	8	23	2	10380922
Pubmed	Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation.	LRP1 LRP2 TENM4	1.40e-05	71	23	3	33541421
Pubmed	Targeted inactivation of the mouse alpha 2-macroglobulin gene.	LRP1 LDLR	1.50e-05	9	23	2	7544347
Pubmed	LDL receptor-related protein as a component of the midkine receptor.	LRP1 LRP2	1.50e-05	9	23	2	10772929
Pubmed	Disabled-2 colocalizes with the LDLR in clathrin-coated pits and interacts with AP-2.	LRP1 LDLR	1.50e-05	9	23	2	11247302
Pubmed	LRP2 mediates folate uptake in the developing neural tube.	LRP1 LRP2	2.29e-05	11	23	2	24639464
Pubmed	Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.	LRP1 LDLR CFAP95 ADAMTS13	2.31e-05	257	23	4	16335952
Pubmed	Normal development and fertility of knockout mice lacking the tumor suppressor gene LRP1b suggest functional compensation by LRP1.	LRP1 LRP2	3.79e-05	14	23	2	15082773
Pubmed	Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.	LRP1 LRP2 LDLR	4.04e-05	101	23	3	23382219
Pubmed	Deficiency of Lipoprotein Lipase in Neurons Decreases AMPA Receptor Phosphorylation and Leads to Neurobehavioral Abnormalities in Mice.	LRP1 SORL1	4.99e-05	16	23	2	26263173
Pubmed	Histone H3.3 maintains genome integrity during mammalian development.	ATRX SLBP	4.99e-05	16	23	2	26159997
Pubmed	Genetic loci controlling body fat, lipoprotein metabolism, and insulin levels in a multifactorial mouse model.	LRP2 LDLR	8.72e-05	21	23	2	9616220
Pubmed	Differential expression and function of ABCG1 and ABCG4 during development and aging.	EIF2AK3 LDLR	9.59e-05	22	23	2	19633360
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	ATRX LRP1 KCNN1 LRP2 LIMK1 KDM4A	1.48e-04	1285	23	6	35914814
Pubmed	Phosphoproteomics screen reveals akt isoform-specific signals linking RNA processing to lung cancer.	ATRX EIF2AK3	1.56e-04	28	23	2	24462114
Pubmed	Analysis of lipid pathway genes indicates association of sequence variation near SREBF1/TOM1L2/ATPAF2 with dementia risk.	LRP1 LDLR	1.68e-04	29	23	2	20167577
Pubmed	Pharmacogenetic predictors of statin-mediated low-density lipoprotein cholesterol reduction and dose response.	LRP2 LDLR	1.92e-04	31	23	2	20031551
Pubmed	Establishment and Dysfunction of the Blood-Brain Barrier.	LRP1 LRP2	5.44e-04	52	23	2	26590417
Pubmed	Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.	MFRP LDLR SSC5D	5.71e-04	248	23	3	24006456
Interaction	ZFP41 interactions	LRP1 LRP2 LDLR SORL1	4.05e-07	57	22	4	int:ZFP41
Interaction	EGFL6 interactions	LRP2 LDLR SORL1	1.48e-06	21	22	3	int:EGFL6
Interaction	NTN5 interactions	LRP2 LDLR SORL1	2.25e-06	24	22	3	int:NTN5
Interaction	GOLGA8G interactions	SLBP LDLR SORL1	2.25e-06	24	22	3	int:GOLGA8G
Interaction	DLK2 interactions	LRP2 EIF2AK3 LDLR	7.88e-06	36	22	3	int:DLK2
Interaction	GREM2 interactions	LRP2 LDLR SORL1	8.56e-06	37	22	3	int:GREM2
Interaction	LDLRAP1 interactions	LRP1 LRP2 LDLR	8.56e-06	37	22	3	int:LDLRAP1
Interaction	APOE interactions	LRP1 LRP2 LDLR SORL1	3.25e-05	171	22	4	int:APOE
Interaction	ANKRD36B interactions	LRP1 LRP2 SORL1	3.71e-05	60	22	3	int:ANKRD36B
Interaction	LRPAP1 interactions	LRP1 LRP2 LDLR SORL1	3.97e-05	180	22	4	int:LRPAP1
Interaction	IGFL3 interactions	LRP2 LDLR SORL1	7.25e-05	75	22	3	int:IGFL3
Interaction	TAFA3 interactions	LRP2 LDLR SORL1	8.15e-05	78	22	3	int:TAFA3
Interaction	NGF interactions	ITGA9 LRP1	8.81e-05	13	22	2	int:NGF
Interaction	SNX17 interactions	LRP1 LRP2 LDLR	9.12e-05	81	22	3	int:SNX17
Interaction	LRP1B interactions	LRP1 LRP2 LDLR	1.05e-04	85	22	3	int:LRP1B
Interaction	CUBN interactions	LRP1 LRP2	1.18e-04	15	22	2	int:CUBN
Interaction	TIMP3 interactions	LRP2 LDLR SORL1	1.25e-04	90	22	3	int:TIMP3
Interaction	MDK interactions	LRP1 LRP2 SORL1	1.29e-04	91	22	3	int:MDK
Interaction	DEFB123 interactions	LDLR SORL1	1.35e-04	16	22	2	int:DEFB123
Interaction	SCN3A interactions	LRP1 LRP2	1.35e-04	16	22	2	int:SCN3A
Interaction	CTSG interactions	LRP1 LDLR SORL1	1.46e-04	95	22	3	int:CTSG
Interaction	CCN6 interactions	LDLR SORL1	1.92e-04	19	22	2	int:CCN6
Interaction	DAB1 interactions	LRP1 LRP2 LDLR	2.08e-04	107	22	3	int:DAB1
Interaction	ZNF224 interactions	LRP2 SORL1	2.14e-04	20	22	2	int:ZNF224
Interaction	ZDHHC15 interactions	LRP1 LRP2 TENM4	3.29e-04	125	22	3	int:ZDHHC15
Interaction	LGALS1 interactions	ITGA9 LRP2 LDLR SORL1	4.18e-04	332	22	4	int:LGALS1
Interaction	FEZF1 interactions	LRP2 SORL1	4.23e-04	28	22	2	int:FEZF1
Interaction	ZNF517 interactions	LRP2 SORL1	4.54e-04	29	22	2	int:ZNF517
Interaction	DAB2 interactions	LRP1 LRP2 LDLR	4.59e-04	140	22	3	int:DAB2
Interaction	ZNF408 interactions	LRP2 LDLR SORL1	5.08e-04	145	22	3	int:ZNF408
Interaction	ITGB1BP1 interactions	LRP1 LRP2	5.88e-04	33	22	2	int:ITGB1BP1
Interaction	ANKS1B interactions	LRP1 LRP2	6.25e-04	34	22	2	int:ANKS1B
Interaction	LPL interactions	LRP1 LRP2	6.62e-04	35	22	2	int:LPL
Interaction	SOST interactions	LRP2 SORL1	6.62e-04	35	22	2	int:SOST
Interaction	VEGFD interactions	ITGA9 SORL1	7.81e-04	38	22	2	int:VEGFD
Interaction	DSCAM interactions	ATRX KCNN1 LIMK1	8.21e-04	171	22	3	int:DSCAM
Interaction	CCN2 interactions	LRP1 LRP2	8.65e-04	40	22	2	int:CCN2
Interaction	TRMT44 interactions	LRP1 LDLR	8.65e-04	40	22	2	int:TRMT44
Interaction	ZNF264 interactions	LRP2 SORL1	9.09e-04	41	22	2	int:ZNF264
Interaction	SPRR1B interactions	ITGA9 KDM4A	1.09e-03	45	22	2	int:SPRR1B
Interaction	CMA1 interactions	LDLR SORL1	1.14e-03	46	22	2	int:CMA1
Interaction	TAFA2 interactions	LDLR SORL1	1.19e-03	47	22	2	int:TAFA2
Interaction	APBA2 interactions	LRP1 LRP2	1.24e-03	48	22	2	int:APBA2
Interaction	WNT3A interactions	LRP1 LDLR	1.30e-03	49	22	2	int:WNT3A
Interaction	DKK2 interactions	LRP2 SORL1	1.30e-03	49	22	2	int:DKK2
Interaction	FOXD4L6 interactions	LDLR SORL1	1.30e-03	49	22	2	int:FOXD4L6
Interaction	TYW3 interactions	LDLR SORL1	1.52e-03	53	22	2	int:TYW3
Interaction	SERPINE1 interactions	LRP1 LRP2	1.57e-03	54	22	2	int:SERPINE1
Interaction	SMOC1 interactions	ITGA9 LRP1	1.57e-03	54	22	2	int:SMOC1
GeneFamily	Low density lipoprotein receptors	LRP1 LRP2 LDLR	1.31e-07	13	15	3	634
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ITGA9 LRP1 SSC5D ADAMTS13 TENM4	3.53e-08	185	23	5	3b2dfc8f4c87be516265dbecfc251276034d0efd
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ITGA9 LRP1 SSC5D TENM4	2.02e-06	179	23	4	02c90d8306016365ed811f0c63cfb3ac7b85464c
ToppCell	Control-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ITGA9 LRP1 SSC5D TENM4	2.21e-06	183	23	4	7eae9b3b4d1c9b135fa7cff348393d4adec474b4
ToppCell	Control-Stromal_mesenchymal-Lung_smooth_muscle\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ITGA9 LRP1 SSC5D TENM4	2.51e-06	189	23	4	45e588b2a4ad9e3ff74e22d9d627ed3571f3b8b8
ToppCell	Control-Stromal_mesenchymal\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ITGA9 LRP1 SSC5D TENM4	2.62e-06	191	23	4	14057205ddb9b4bbc582d1358d13cf36d979a61b
ToppCell	LPS_IL1RA-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	ITGA9 LRP1 SSC5D ADAMTS13	3.08e-06	199	23	4	6b3a0e5d52a30d0eed30e6a670f5b53bc233f70c
ToppCell	LPS_anti-TNF-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	ITGA9 LRP1 SSC5D ADAMTS13	3.08e-06	199	23	4	38cfd367ee8c074c11ba54edeb7a001e375e2687
ToppCell	LPS_only-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast\|LPS_only / Treatment groups by lineage, cell group, cell type	ITGA9 LRP1 SSC5D ADAMTS13	3.14e-06	200	23	4	a9ff3210127000b3dd9e97136163c98c2b0817d7
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	PLEKHS1 ADAMTS13 SORL1	5.31e-05	143	23	3	5fb5a4ea93e5cce55d427e3b4a50a979504fad3c
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1-Bcl6\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	KCNN1 PLEKHS1 SORL1	5.43e-05	144	23	3	08005be9e3367f78ef27e125d9cce5ca53f4bd2d
ToppCell	facs-Brain_Myeloid-Cortex-3m-Myeloid-macrophage\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP2 LDLR TLR8	6.50e-05	153	23	3	0ef7c45cdd854c79e527006034029767f8e108b2
ToppCell	368C-Myeloid-Monocyte-CD16+_Monocyte\|368C / Donor, Lineage, Cell class and subclass (all cells)	KCNN1 LRP2 SORL1	6.88e-05	156	23	3	25b0936960be4955b6a6d6b8a867fdd4be548f05
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-24m-Macroglial-astrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITGA9 LIMK1 SORL1	7.56e-05	161	23	3	9f02b94e29e60d50e92eaa748ebf0c36d3671bb3
ToppCell	facs-BAT-Fat-3m-Myeloid-nan\|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP1 LDLR TLR8	9.19e-05	172	23	3	5f18c3f8eb8b7928901eede44c9b84b3c5efa1a9
ToppCell	Children_(3_yrs)-Mesenchymal-myofibroblast_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ITGA9 SSC5D TENM4	9.35e-05	173	23	3	1f16d47f5548e257e4b17f8070c5619780a9c5fd
ToppCell	10x5'-bone_marrow-Myeloid_Mac-Intestinal_macrophages\|bone_marrow / Manually curated celltypes from each tissue	ITGA9 LRP1 SSC5D	9.51e-05	174	23	3	0746344d62aa7ab77c378e9d5a9f9238e741a76b
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.5\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PLEKHS1 LDLR SORL1	1.03e-04	179	23	3	6e965e424eebef50f0202cff75f458be395cfca1
ToppCell	Fetal_29-31_weeks-Mesenchymal-myofibroblast_cell-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ITGA9 SSC5D TENM4	1.07e-04	181	23	3	d7e04e0ca549eac6d9b1192b6578f9b54943d54f
ToppCell	LPS_only-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ITGA9 SSC5D TENM4	1.10e-04	183	23	3	12daaea821e49bc94a01e2496331e92a80d27339
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ITGA9 LDLR TENM4	1.12e-04	184	23	3	ab2f06906fc7a9931dfa0864ef506832b07fb93e
ToppCell	PCW_05-06-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^high_distal_(10)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	LRP2 IQANK1 SORL1	1.12e-04	184	23	3	fa4915b0498f3069fd5ef497286445528f75187e
ToppCell	343B-Fibroblasts-Fibroblast-E\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	ITGA9 SLBP SSC5D	1.14e-04	185	23	3	02cbf492bc40abebaa93a3a208888afae72fbe06
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ITGA9 ADAMTS13 TENM4	1.14e-04	185	23	3	6712512100ccef456d2e2bd201d0987986c92ac9
ToppCell	343B-Fibroblasts-Fibroblast-E-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	ITGA9 SLBP SSC5D	1.14e-04	185	23	3	1b8e3ddb91797f84e4b15d2457b0c008e5be50db
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ITGA9 LDLR TENM4	1.16e-04	186	23	3	e83718fabb057100835d3357df407f283d23fe16
ToppCell	Fetal_29-31_weeks-Mesenchymal-myofibroblast_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ITGA9 SSC5D TENM4	1.18e-04	187	23	3	c104fbfef2d0bef64077ac721edf2379fd59d547
ToppCell	Mesenchymal-myofibroblast_cell\|World / Lineage, Cell type, age group and donor	ITGA9 SSC5D TENM4	1.21e-04	189	23	3	44e37f88137bb249933eb615235b2cf2ae7f3925
ToppCell	Control-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ITGA9 SSC5D TENM4	1.25e-04	191	23	3	b133ee1c0e58d00ddd2e4e05b01fd04947524c18
ToppCell	facs-Trachea-nan-3m-Epithelial-mucus_secreting_cell\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP2 PLEKHS1 TENM4	1.29e-04	193	23	3	3038ed3e53d3367136fac5c9773cd5b7414f49d3
ToppCell	wk_20-22-Epithelial-Proximal_epithelial-MUC16+_ciliated\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	IQANK1 PLEKHS1 CFAP95	1.31e-04	194	23	3	756082a0f5953b52229bb60d40b84701cb6cb23d
ToppCell	control-Myeloid-Non-resident_Macrophage\|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	LRP1 LDLR SORL1	1.37e-04	197	23	3	df2fe36cb96e2565a9d21c24cb4e451e8befd4be
ToppCell	P03-Mesenchymal-myocytic_cell\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	ITGA9 SSC5D TENM4	1.37e-04	197	23	3	079db904a08743b3c555cb7b3f5fb5c978dde25a
ToppCell	PND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ITGA9 SSC5D TENM4	1.37e-04	197	23	3	9d7a1c7dc70ba5e35645f19f9e056e4fa2494aa0
ToppCell	10x3'2.3-week_17-19-Mesenchymal_adipo-stroma\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	LRP1 PLEKHS1 TENM4	1.37e-04	197	23	3	b9745e382baa2725dfcae060701fb53f6c8a31fa
ToppCell	PND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ITGA9 SSC5D TENM4	1.37e-04	197	23	3	090a251194da3e2806989d9a522588f83f52da7f
ToppCell	10x3'2.3-week_17-19-Mesenchymal_adipo\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	LRP1 PLEKHS1 TENM4	1.37e-04	197	23	3	5afddde4e2b5cd55abe11e9b9efae02dbdc3da3a
ToppCell	10x3'2.3-week_17-19-Mesenchymal_adipo-stroma-adipo-CAR\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	LRP1 PLEKHS1 TENM4	1.37e-04	197	23	3	1baffd087ca194a7355fefbb3bf67befb14fe2de
ToppCell	P03-Mesenchymal-myocytic_cell-aortic_smooth_muscle_cell\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	ITGA9 SSC5D TENM4	1.37e-04	197	23	3	2cec938caf6ffd031cea37277071487e59b2c71c
ToppCell	background-Hepatic_Stellate_cells\|background / Sample and Cell Type and Tumor Cluster (all cells)	ITGA9 SSC5D ADAMTS13	1.39e-04	198	23	3	bd11b0e9e80449aab979a02c1023e0638c431c7c
ToppCell	COVID-19_Mild-Classical_Monocyte\|COVID-19_Mild / Disease condition and Cell class	LRP1 LDLR SORL1	1.39e-04	198	23	3	30ada3de865b6fb2b14196a1cbfd4740c6a57ce3
ToppCell	Transverse-Macrophage-LYVE1_Macrophage\|Transverse / Region, Cell class and subclass	LRP1 SSC5D TLR8	1.41e-04	199	23	3	facf79c256db5ae57bdb613e86ec90616a6f67ca
ToppCell	Transverse-(6)_Macrophage-(61)_LYVE1_Macrophage\|Transverse / shred on region, Cell_type, and subtype	LRP1 SSC5D TLR8	1.41e-04	199	23	3	dcc2a7f4d1fa30aaaad655dd59c5a2b039d264bf
ToppCell	LPS_only-Mesenchymal_myocytic-Myofibroblastic\|LPS_only / Treatment groups by lineage, cell group, cell type	ITGA9 SSC5D ADAMTS13	1.44e-04	200	23	3	02cae2c296a13ad4cbb53bca7a86d64629d67d66
ToppCell	Control_saline-Mesenchymal_myocytic-Myofibroblastic\|Control_saline / Treatment groups by lineage, cell group, cell type	ITGA9 LRP1 SSC5D	1.44e-04	200	23	3	9d5b3c2dcfa55d50acc2ce2c319d51aa525d4cd1
ToppCell	Control_saline-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast\|Control_saline / Treatment groups by lineage, cell group, cell type	ITGA9 LRP1 SSC5D	1.44e-04	200	23	3	a799fc7bb83ad0524362cb5010df949741fb7bf3
ToppCell	LPS_IL1RA_TNF-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	LRP1 SSC5D ADAMTS13	1.44e-04	200	23	3	09537dc25f8b8b4654a7c183827ee1522a41a4e0
ToppCell	Frontal_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Cplx3-Inhibitory_Neuron.Gad1Gad2.Cplx3-Reln_(Neuron.Gad1Gad2.Cplx3-Reln)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	LRP2 PLEKHS1	4.49e-04	61	23	2	fec6c9a4e12c260338856567bf547f914f473dbb
ToppCell	Frontal_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Cplx3-Inhibitory_Neuron.Gad1Gad2.Cplx3-Reln_(Neuron.Gad1Gad2.Cplx3-Reln)-\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	LRP2 PLEKHS1	4.49e-04	61	23	2	06aab3f1743ced1e46d22f0310f1cdb70c7a108e
ToppCell	Control-B_naive-4\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	SSC5D ADAMTS13	1.30e-03	104	23	2	5f72aa686b0fb83d401621e1b9d9c69e56105570
ToppCell	Mild/Remission-B_naive-12\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	SSC5D SORL1	1.37e-03	107	23	2	1ab09acb66e4282688fd1f6782a4009f4ea18c41
ToppCell	Frontal_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Nptxr-Excitatory_Neuron.Slc17a7.Nptxr-Deptor_(Deep_layer_pyramidal_cells--Layer_5a)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	CFAP95 ADAMTS13	1.40e-03	108	23	2	514dfc3f7ac303311ae599f981f3f3c7eb6801b8
ToppCell	TCGA-Breast-Primary_Tumor-Breast_Carcinoma-Infiltrating_Lobular_Carcinoma-1\|TCGA-Breast / Sample_Type by Project: Shred V9	HEXIM2 NUDT6	1.50e-03	112	23	2	518b7ab98b988b23f3d0f0e1f4fe90a7068f9d87
ToppCell	TCGA-Breast-Primary_Tumor-Breast_Carcinoma-Papillary_Carcinoma\|TCGA-Breast / Sample_Type by Project: Shred V9	CFAP95 HEXIM2	1.58e-03	115	23	2	5f6f6a0f59f0f68aa20f9d98a15118176281ace6
ToppCell	Severe-B_naive-13\|Severe / disease group and sub_cluster of B and Plasma cells(res = 0.5)	CAGE1 ADAMTS13	1.61e-03	116	23	2	f81a7c3e9cbf39124232d98e2a3a3e308137f391
ToppCell	Control-B_naive-4\|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)	SSC5D ADAMTS13	1.61e-03	116	23	2	35d471c8dbf408d0be3837c428d9c2a73c805a6f
ToppCell	PND07-28-samps-Lymphocyte-T_cells-T_cells_1\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	MFRP PLEKHS1	1.66e-03	118	23	2	461a971f3e8047c727b7c6e00d2d64e97d50c6de
ToppCell	Severe-B_naive-13\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	CAGE1 ADAMTS13	1.72e-03	120	23	2	d08edc09de8497714af55a6ca08a447cd71095e7
ToppCell	TCGA-Kidney-Primary_Tumor-Renal_Cell_Carcinoma-Kidney_Papillary_Renal_Cell_Carcinoma-2\|TCGA-Kidney / Sample_Type by Project: Shred V9	PLEKHS1 SSC5D	1.92e-03	127	23	2	50055d5b781e40737e00fa3244cbf9a7517f14b1
ToppCell	TCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Acinar_Adenocarcinoma-7\|TCGA-Lung / Sample_Type by Project: Shred V9	ITGA9 SSC5D	2.01e-03	130	23	2	0219d0d5d21df08f816569c7eb34f1bfa095d29a
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ITGA9 LDLR	2.11e-03	133	23	2	5bf5e654653e2c340891f51e3f2a30441b7b6b2b
ToppCell	10x_3'_v3-tissue-resident_(10x_3'_v3)-myeloid-myeloid_dendritic-CD141-positive_myeloid_dendritic_cell\|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	KCNN1 CFAP95	2.14e-03	134	23	2	0b1bb6fee8a2d8c27bca6d9cac6b47e85073dbf7
ToppCell	E16.5-samps-Mesenchymal-Myofibroblast-myofibroblast_-_immature_-_proliferative\|E16.5-samps / Age Group, Lineage, Cell class and subclass	ITGA9 TENM4	2.20e-03	136	23	2	96370f0e3abf1c9ec7a91595b5d0f97ac2ab4b78
ToppCell	TCGA-Breast-Primary_Tumor-Breast_Carcinoma-Mucinous_Carcinoma\|TCGA-Breast / Sample_Type by Project: Shred V9	LRP2 CFAP95	2.33e-03	140	23	2	82b150e9e9962460a5cd6bef7ee04f28f5c05d1a
ToppCell	10x5'-Lung-Myeloid_Mac-Intestinal_macrophages\|Lung / Manually curated celltypes from each tissue	ITGA9 CFAP95	2.36e-03	141	23	2	7671d300b1722711fd2d8034b96a3aa7e3ccb560
ToppCell	PBMC-Severe-Lymphocyte-B-B_cell-B_naive-B_naive-13\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CAGE1 ADAMTS13	2.46e-03	144	23	2	b2a9f3b5dd46d27689467f4a5fd717cd5827821f
ToppCell	facs-Lung-3m-Hematologic-lymphocytic-CD8-positive,_alpha-beta_T_cell-CD8-positive,_alpha-beta_T_cell_l21\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CAGE1 MCM9	2.63e-03	149	23	2	efa30fcd9370f98eb7445f295eb4d0305ff455c3
ToppCell	TCGA-Breast-Primary_Tumor-Breast_Carcinoma-Mucinous_Carcinoma-1\|TCGA-Breast / Sample_Type by Project: Shred V9	LRP2 CFAP95	2.63e-03	149	23	2	649eb3441fa859591ea85f1ed5fcf08af272a32b
ToppCell	Ciliated_cells-A-IPF_02\|World / lung cells shred on cell class, cell subclass, sample id	PLEKHS1 CFAP95	2.70e-03	151	23	2	9d03ce73af15ef40c592d19b36aff46bebc14c40
ToppCell	343B-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0\|343B / Donor, Lineage, Cell class and subclass (all cells)	CAGE1 SORL1	2.70e-03	151	23	2	78475027bba9e3026e42493fec8ea630972353bb
ToppCell	droplet-Marrow-BM_(NON-STC)-30m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP1 SORL1	2.74e-03	152	23	2	82a493ffb2f1704cd6f68a82d970fe12f537d20e
ToppCell	Smart-seq2-lymph_node_(Smart-seq2)-myeloid-myeloid_monocytic\|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	LDLR TLR8	2.74e-03	152	23	2	072daae0deb6cb92f126e4566f1d264cda9ed157
ToppCell	facs-Lung-Endomucin-24m-Myeloid-classical_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP1 TLR8	2.77e-03	153	23	2	9c3220604b7fa4d91577b6c46960960f49644ca1
ToppCell	droplet-Fat-SCAT-30m-Myeloid-monocyte\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TLR8 TENM4	2.77e-03	153	23	2	2731c3d4ac40ecc22108f8f3f45a069077159125
ToppCell	facs-Lung-Endomucin-24m-Myeloid-Classical_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP1 TLR8	2.77e-03	153	23	2	ba624782693b0daa642e50881dbf5f0663fea82d
ToppCell	facs-Brain_Non-Myeloid-Hippocampus_-18m-Macroglial-astrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP1 SSC5D	2.81e-03	154	23	2	5ed64bbf603290e6dc34f81d145982690b89dd0d
ToppCell	E16.5-samps-Mesenchymal-Myofibroblast-Migrating_MyoFibroblast\|E16.5-samps / Age Group, Lineage, Cell class and subclass	ITGA9 MFRP	2.85e-03	155	23	2	1882fa5fd25f77d6e3ac47b613f6fb3c67d8e50c
ToppCell	(03)_Secretory-(2)_48hpi\|(03)_Secretory / shred by cell type and Timepoint	SLBP ADAMTS13	2.85e-03	155	23	2	d3b3d5764dfccaa4564f6063da7e13633a4f4b73
ToppCell	10x5'-bone_marrow-Lymphocytic_Invariant-Inducer-like-ILC3\|bone_marrow / Manually curated celltypes from each tissue	LRP2 ADAMTS13	2.85e-03	155	23	2	83430a64c2cb5ad29caa3dacba76c28dd204ac40
ToppCell	facs-Brain_Myeloid-Cortex_-18m-Myeloid-macrophage\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LDLR TLR8	2.88e-03	156	23	2	2ba838bc864c2c1767bcab7bb4d790af96b91387
ToppCell	Control-Endothelial-Epi-like-Alv_Cap\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	KCNN1 LIMK1	2.92e-03	157	23	2	2c369660c752c0fb3bd798a561d3359e2f9aa983
ToppCell	wk_15-18-Mesenchymal-Myofibro_&_SMC-Myofibro_2\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	ITGA9 SSC5D	2.92e-03	157	23	2	b9d04ee417c0d8ea0801d10f1c54e138587009fd
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Fibroblasts\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ADAMTS13 NUDT6	2.92e-03	157	23	2	f086753b51860e23f1275bd75e8802d2a7d7b70a
ToppCell	Control-Endothelial-Epi-like\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	KCNN1 LIMK1	2.92e-03	157	23	2	4d02c50d5d1b892ea241e98724386d8a5a156a46
ToppCell	Smart-seq2-lymph_node_(Smart-seq2)-myeloid-myeloid_monocytic-non-classical_monocyte\|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	LDLR TLR8	2.95e-03	158	23	2	be9d7410f152071e3af971bc09181818070228a0
ToppCell	BAL-Severe-cDC_4\|Severe / Compartment, Disease Groups and Clusters	HEXIM2 TENM4	2.95e-03	158	23	2	73f66689ef59f71b14cb7141ca5951cc47fe57c1
ToppCell	343B-Lymphocytic-NK_cells-NK_cell_D2\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	PLEKHS1 TLR8	2.95e-03	158	23	2	74aa4f75307575ac3b2b1aa9f727753692f88742
ToppCell	droplet-Liver-Hepatocytes-18m-Myeloid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITGA9 LRP1	2.95e-03	158	23	2	d3446fc98eff09c3626b47a2c90d07cd985378b5
ToppCell	facs-Lung-EPCAM-3m-Myeloid-Nonclassical_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP1 TLR8	2.95e-03	158	23	2	b0508a600994090c6aafd8d779437190a33ad821
ToppCell	facs-Lung-EPCAM-3m-Myeloid-classical_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP1 TLR8	2.95e-03	158	23	2	ef5feb48161c339c7b71c576bdda61479d29dfac
ToppCell	droplet-Liver-Hepatocytes-18m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITGA9 LRP1	2.95e-03	158	23	2	df614450e10629dc9115d7365397663e82f9e48f
ToppCell	facs-Lung-EPCAM-3m-Myeloid-Classical_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP1 TLR8	2.95e-03	158	23	2	c6e64b9b3342e37d54baadae8fb7dfb5d246e4cf
ToppCell	facs-Lung-EPCAM-3m-Myeloid-non-classical_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP1 TLR8	2.95e-03	158	23	2	a816cc095452308d06f87b77467e2a8c6361fd2a
ToppCell	droplet-Kidney-KIDNEY-1m-Lymphocytic-lymphocyte\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SSC5D MCM9	2.99e-03	159	23	2	3bab00f8fb7d9232538e50f83dd0fd70ddd16819
ToppCell	facs-Brain_Myeloid-Cerebellum-3m-Myeloid-macrophage\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LDLR TLR8	2.99e-03	159	23	2	323cb4a2416d2e6bff0a3f225d2edeae9ab7dc76
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ITGA9 LDLR	2.99e-03	159	23	2	8680b054622f573a82b1625fb93c2d5db81d1034
ToppCell	droplet-Heart-nan-24m-Mesenchymal-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCNN1 SORL1	2.99e-03	159	23	2	7ad3a91d29639b32f6264c91f401c14a35469ac0
ToppCell	10x5'v1-week_17-19-Lymphocytic_B-B_lineage-pro_B_progenitor\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	EIF2AK3 HEXIM2	3.03e-03	160	23	2	30b7f24e0c3ecfa618b4e31678e18c8a4405a8d7
ToppCell	facs-MAT-Fat-18m-Myeloid-myeloid_cell\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TLR8 SORL1	3.03e-03	160	23	2	bd5fa7959bfe81011b8d798535b73ea1eee008b3
ToppCell	NS-critical-LOC-Myeloid-Basophil\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	ITGA9 SSC5D	3.03e-03	160	23	2	8a4746463ca1976f7d6de803496c851249ced797
ToppCell	droplet-Kidney-KIDNEY-1m-Lymphocytic-CD45\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SSC5D MCM9	3.03e-03	160	23	2	5bec867def73fa8531f8dad611679f4b44f573bd
Computational	Genes in the cancer module 236.	LDLR SORL1	2.38e-04	18	14	2	MODULE_236
Drug	monatepil	LRP1 LRP2 LDLR SORL1	1.85e-08	29	23	4	CID000060810
Drug	Y-27632	ITGA9 MFRP LRP1 EIF2AK3 LIMK1 NUDT6	4.05e-06	444	23	6	CID000005711
Drug	pitavastatin	LRP1 LRP2 LDLR SORL1	4.90e-06	114	23	4	CID005282451
Drug	chloroquine	MFRP LRP1 LRP2 LDLR TLR8	8.73e-06	288	23	5	CID000002719
Drug	ezetimibe	LRP1 LRP2 LDLR SORL1	1.34e-05	147	23	4	CID000150311
Drug	25-hydroxycholesterol	LRP1 LRP2 LDLR SORL1	1.87e-05	160	23	4	CID000065094
Drug	probucol	LRP1 LRP2 LDLR SORL1	1.97e-05	162	23	4	CID000004912
Drug	epicholesterol	MFRP LRP1 LRP2 LDLR TLR8 SORL1	3.12e-05	636	23	6	CID000000304
Drug	coprogen	LRP1 LRP2	3.50e-05	9	23	2	CID006323272
Drug	Nifuroxazide [965-52-6]; Down 200; 14.6uM; MCF7; HT_HG-U133A	ATRX LRP2 LDLR LIMK1	3.53e-05	188	23	4	4835_DN
Drug	LMWH	MFRP LRP1 LRP2 LDLR ADAMTS13 NUDT6	3.94e-05	663	23	6	CID000000772
Drug	25-azacoprostane	LRP1 LRP2	4.37e-05	10	23	2	CID000162243
Drug	Methiazole; Up 200; 15uM; MCF7; HT_HG-U133A	KCNN1 PLEKHS1 LIMK1 TENM4	4.40e-05	199	23	4	3878_UP
Drug	P-Nz	ITGA9 NUDT6	6.40e-05	12	23	2	CID000029146
Drug	fenoxycarb	LRP1 KCNN1 LDLR	7.03e-05	80	23	3	CID000051605
Drug	AC1L1J6H	LRP1 LRP2 LDLR SORL1	8.53e-05	236	23	4	CID000004889
Drug	pifarnine	LDLR NUDT6	1.48e-04	18	23	2	CID006436032
Drug	dhpta	MFRP LDLR NUDT6	1.53e-04	104	23	3	CID000018465
Drug	Calpain inhibitor I	LRP1 LRP2 LDLR SORL1	1.65e-04	280	23	4	CID000004332
Drug	AC1L9732	MFRP LRP2 NUDT6	2.01e-04	114	23	3	CID000439300
Drug	clioquinol	ITGA9 LRP1 LRP2	2.01e-04	114	23	3	CID000002788
Disease	3-carboxy-4-methyl-5-propyl-2-furanpropanoate CMPF measurement	KCNN1 TENM4	4.51e-05	13	23	2	EFO_0021053
Disease	opioid use disorder	KCNN1 KDM4A SORL1	6.56e-05	101	23	3	EFO_0010702
Disease	Alzheimer's disease (is_implicated_in)	LRP1 LDLR SORL1	1.45e-04	132	23	3	DOID:10652 (is_implicated_in)
Disease	systemic lupus erythematosus (is_marker_for)	LDLR ADAMTS13	6.15e-04	47	23	2	DOID:9074 (is_marker_for)
Disease	Abdominal Aortic Aneurysm	LRP1 LDLR	1.28e-03	68	23	2	EFO_0004214

Protein segments in the cluster

Peptide	Gene	Start	Entry
RSEACRENCEMPDWE	CAGE1	276	Q8TC20
CSALGCRQWDSDEME	EIF2AK3	216	Q9NZJ5
GCDGRMDSQQVWDRC	ADAMTS13	531	Q76LX8
MDSLDRSCQDWCDRK	CFAP95	1	Q5VTT2
DMWRDCTDGSDDNCS	MFRP	441	Q9BY79
IPLRWRCDADADCMD	LRP1	3626	Q07954
DNGADDWRIAMTCER	KCNN1	171	Q92952
EECLRCEWMDLNDLA	NUDT6	241	P53370
WMCSRCSANALEEDC	KDM4A	761	O75164
RAWLCDRDNDCGDMS	LRP2	1286	P98164
SCGKTCREDRDDEWM	ITGA9	111	Q13797
CREDRDDEWMGVSLA	ITGA9	116	Q13797
RDSDGMDEQCRWCAE	ATRX	211	P46100
LGDEAFDCDWDEEMR	MCM9	1126	Q9NXL9
WCDFDNDCGDMSDER	SORL1	1096	Q92673
IRSSWVCDGDNDCRD	SORL1	1171	Q92673
RCSDWASAVEEDEMR	SLBP	71	Q14493
QMWNREGCRCDEEPG	HEXIM2	271	Q96MH2
RRISEHDQCEWRCMD	IQANK1	341	A8MXQ7
WDMRDSAVVCRELGC	SSC5D	496	A1L4H1
DVAKRACMESDWCRD	PLEKHS1	421	Q5SXH7
CTCDIGDFRRWMDEH	TLR8	776	Q9NR97
CEDGWMGAACDQRAC	TENM4	746	Q6N022
CNMARDCRDWSDEPI	LDLR	296	P01130
LCCTWREERMGEEGS	LIMK1	6	P53667